This study reports on current work involving the use of Surface Enhanced Raman Spectroscopy (SERS) for the intracellular detection of cell constituents in mouse fibroblast cells using gold nanoshells. Gold nanoshells were acquired from Nanospectra Biosciences that are based on a silica dielectric core and an outer gold shell layer. They have the unique property of a tunable surface plasmon resonance wavelength from the visible through the near infrared which allows control of the electromagnetic field strength on its surface. Hence gold nanoshells can serve as SERS substrates with plasmonic properties that are not aggregation dependent and thus can be expected to overcome the reproducibility problem that is generally associated with aggregation based colloidal metal nanoparticles. These results represent the first steps in the development of a nanoshell-based SERS probe to detect cell organelles and/or intracellular biochemicals with the goal of ultimately improving the ability to monitor ...
nanoShell Stone Protector S is a clear, solvent based ready-to-use coating that protects facades from physical and chemical damages. nanoShell Stone Protector S forms a permanent monomolecular layer inside the capillaries that make the pore surface water-
The current median survival of patients with glioblastoma multiforme (GBM), the most common type of glioma, remains at 14.6 months despite multimodal treatments (surgery, radiotherapy and chemotherapy). This research aims to study the feasibility of photothermal ablation of glioma using gold nanoshells that are heated upon laser irradiation at their resonance wavelength. The novelty of our approach lies in improving nanoshell tumor delivery by loading them in macrophages, which are known to be recruited to gliomas via tumor-released chemoattractive agents. Ferumoxides, superparamagnetic iron oxide (SPIO) nanoparticles, are needed as an additional macrophage load in order to visualize macrophage accumulation in the tumor with magnetic resonance imaging (MRI) prior to laser irradiation. The feasibility of this approach was studied in an in vitro model of glioma spheroids with the use of continuous wave (CW) laser light for ablation. The optimal loading of both murine and rat macrophages with Ferumoxides
Third-order nonlinear optical properties of gold nanoshells of different thickness were investigated over a broad wavelength range (530-1200 nm) by the Z-scan technique using femtosecond laser pulses. Nonlinear absorption of the nanoshells is dominated by strong absorption saturation phenomena. The reciproca
The plasmon resonance in metallic nanoshells can be used to efficiently harvest solar energy and convert it into thermal or electronic form. Possible applications include improved optical coupling into silicon photodiodes, solar water heaters, and photocatalysis. We use standard optimization algorithms to theoretically determine the best mixture of different nanoshell species ([core, shell] sizes) for two practical scenarios. We show that a mixture of nanoshell species [r1, r2] = [47, 58] nm and [r1, r2] = [28, 42] run in a 6:5 volume ratio is optimal for absorbing AM 1.5 sunlight when deposited on a silicon surface. Surprisingly, we find that a single particle species is very good for scattering AM 1.5 light on a glass surface, and that very little benefit is gained by mixing different shells. Assumptions and approximations made in the analysis are discussed ...
The optimization of the coated metallic nanoparticles and nanoshells is a current challenge for biological applications, especially for cancer photothermal therapy, considering both the continuous improvement of their fabrication and the increasing requirement of efficiency. The efficiency of the coupling between illumination with such nanostructures for burning purposes depends unevenly on their geometrical parameters (radius, thickness of the shell) and material parameters (permittivities which depend on the illumination wavelength). Through a Monte-Carlo method, we propose a numerical study of such nanodevice, to evaluate tolerances (or uncertainty) on these parameters, given a threshold of efficiency, to facilitate the design of nanoparticles. The results could help to focus on the relevant parameters of the engineering process for which the absorbed energy is the most dependant. The Monte-Carlo method confirms that the best burning efficiency are obtained for hollow nanospheres and exhibit ...
...HOUSTON -- (Feb. 1 2011) -- Rice University bioengineers and physicia...The results of the new study are available online in the Journal of... This first round of in vivo animal tests suggests that photothermal t...Glioma is among the most aggressive and difficult-to-treat of all brai...,Early,tests,find,nanoshell,therapy,effective,against,brain,cancer,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Page contains details about gold-dielectric-gold multilayer nanoshell surrounded by silver shell . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Nanoparticle-based systems can alleviate systemic toxicity via surface functionalization to promote tissue-specific targeting as well as passive targeting abilities [1], such as the enhanced permeation and retention effect (EPR) [2]. The transport of nanoparticles is limited in hypoxic tumor regions due to the typically impaired tumor vasculature. To enhance diffusion of nanotherapeutics within tumor tissue; functionalized citrate gold nanoparticles and silica gold nanoshells with surface modifications of phosphatidylcholine (PC) and high density lipoprotein (HDL) were synthesized. 3D cell cultures were used as a representative model of portions of hypoxic tissue in liver, lung, and pancreatic solid tumors. Our results indicate that two layered silica gold nanoshells (surface modifications of -thiol and PC) permit enhanced accumulate compared to PEGylated nanoparticles. The addition of HDL for the smaller, citrate gold nanoparticles as a third external layer provided enriched accumulation compared to
James Chen Yong Kah,1 Tzu Hao Chow,2 Beng Koon Ng,2 Sirajudeen Gulam Razul,2 Malini Olivo,3,4,5 and Colin James Richard Sheppard1,* 1Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574 2School of Electrical and Electronics Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 3Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610 4Singapore Bioimaging Consortium, Biomedical Sciences Institutes, 11 Biopolis Way, #02-02 Helios, Singapore 138667 5Department of Pharmacy, National University of Singapore, Blk S4, 18 Science Drive 4, Singapore 117543 *Corresponding author: [email protected] ...
Page contains details about thiol-terminated polyethylene glycol-coated mesoporous plasmonic Ag/Au alloy nanoshells . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Diabetes is an epidemic in developed nations. Glucokinase (GK) is vital for glocose sensing, and is directly implicated in particular forms of diabetes. Studying pancreatic cells with altered GK activity would facilitate studies, but current methods for altering proteomes are lacking. Porous phospholipid nanoshells (PPNs) have traditionally been used as platforms for biologically derived nanosensors, though their biocompatibility and protease resistance well suits them as enzyme delivery agents. GK kinetics were investigated with an enzyme coupled reaction to determine the effect of encapsulation. It was determined that encapsulation increased the Hill coefficient by 5.8% and the S(0.5) by 1.8%. This small deviation may not be significant in physiological conditions. To observe a recovered function in cell lines upon reintroducing GK, constitutively expressed GK must first be knocked down with siRNA. As initial work toward an siRNA knockdown, immunoblotting conditions were optimized resulting in ...
In the conventional non-invasive cancer treatments, such as photodynamic therapy (PDT) and photothermal therapy (PTT), light irradiation is precisely focused on tumors to induce apoptosis via the generation of reactive oxygen species (ROS) or localized heating. However, overconsumption of oxygen and restrict 2017 Nanoscale HOT Article Collection
TY - JOUR. T1 - Gadolinium-enriched polyaniline particles (GPAPs) for simultaneous diagnostic imaging and localized photothermal therapy of epithelial cancer. AU - Lee, Taeksu. AU - Bang, Doyeon. AU - Park, Yeonji. AU - Kim, Sun Hee. AU - Choi, Jihye. AU - Park, Joseph. AU - Kim, Donghun. AU - Kim, Eunkyoung. AU - Suh, Jin Suck. AU - Huh, Yong Min. AU - Haam, Seungjoo. PY - 2014/1/1. Y1 - 2014/1/1. UR - http://www.scopus.com/inward/record.url?scp=84908029000&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84908029000&partnerID=8YFLogxK. U2 - 10.1002/adhm.201300636. DO - 10.1002/adhm.201300636. M3 - Article. C2 - 24550214. AN - SCOPUS:84908029000. VL - 3. SP - 1408. EP - 1414. JO - Advanced healthcare materials. JF - Advanced healthcare materials. SN - 2192-2640. IS - 9. ER - ...
Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triplenegative breast cancer ...
January 8, 2018 - Nasim Ganjis paper "Surface activity of poly(ethylene glycol)-coated silver nanoparticles in the presence of a lipid monolayer" accepted in Langmuir.. August 15, 2017 - Bothun and lab embark on a new collaboration: NIEHS funds URI-led Superfund on fluorinated pollutants (poly- and per-fluoroalkylated substances).. May 9, 2017 - Akram Abbasi publishes her first article in Langmuir! "Near Infrared Responsive Gold-Layersome Nanoshells.". April 25, 2017 - Matt Preiss collaborative work with Kitchens group (Clemson Univ) in J. Phys. Chem. B "Hydrophobic Nanoparticles Modify the Thermal Release Behavior of Liposomes.". December 14, 2016 - Collaborative work with Nasim Ganji, Iftheker Khan, Aihong Xi, and Chris Bobba accepted to Langmuir " Anionic and cationic silver nanoparticle binding restructures net-anionic PC/PG monolayers with saturated or unsaturated lipids.". July 14, 2016 - Yaser Kashcooli successfully defends his M.S. thesis "NIR Light Activated Hollow Gold Nanoshell ...
Photothermal treatment with epidermal growth factor receptor-directed gold nanorods results in considerable antineoplastic activity in an early study of bladder cancer.
BACKGROUND AND OBJECTIVES: Gold nanoparticles (GNPs) such as gold nanoshells (GNSs) and gold nanorods (GNRs) have been explored in a number of in vitro and in vivo studies as imaging contrast and cancer therapy agents due to their highly desirable spectral and molecular properties. While the organ-level biodistribution of these particles has been reported previously, little is known about the cellular level or intra-organ biodistribution. The objective of this study was to demonstrate the use of intrinsic two-photon induced photoluminescence (TPIP) to study the cellular level biodistribution of GNPs. STUDY DESIGN/MATERIALS AND METHODS: Tumor xenografts were created in twenty-seven male nude mice (Swiss nu/nu) using HCT 116 cells (CCL-247, ATCC, human colorectal cancer cell line). GNSs and GNRs were systemically injected 24 hr. prior to tumor harvesting. A skin flap with the tumor was excised and sectioned as 8 $μ$m thick tissues for imaging GNPs under a custom-built multiphoton microscope. For ...
Huang, X., et al. (2017). "Modularized Gold Nanocarriers for TAT-Mediated Delivery of siRNA." Small 13(8):1602473.. Targeted delivery of siRNA controlled by near-infrared light using hollow gold nanoshells has been demonstrated in cancer and stem cells models. Here, a universal surface module and several functionalization rules for the maximized delivery of short nucleic acids (here, siRNA) applicable for diverse gold nanocarriers are described. Streptavidin is devised as a handle to assemble biotinylated cell penetrating peptides (e.g., transactivating transcriptional activator (TAT)), as well as an insulator between the positive charge of TAT and the dense negative charge of RNA. However, direct linking of streptavidin to functional siRNA inhibits its silencing activity. The approach then involves the orthogonal assembly of two types of RNA strands: one with biotin modification for cell targeting and penetration (scaffold RNA); the other without biotin as functional RNA (i.e., siRNA). ...
Roman Yukilevich, assistant professor of biology, was a first co-author on "Incompatibility and Competitive Exclusion of Genomic Segments Between Sibling Drosophila Species," accepted for publication in Plos Genetics. His research investigated the extent to which recently diverged species show genetic incompatibilities, such that genomic regions of one species are unable to be incorporated into the genome of the second species. The Journal of Applied Physics accepted a manuscript written by Rebecca Cortez, assistant professor of mechanical engineering, and colleagues at the Air Force Research Laboratories and Rice University. "Electrical Conductivity of Cationized Ferritin Decorated Gold Nanoshells" addresses the tuning of electrical properties for future generations of nanodimensional electronic circuits. The work was partially funded by National Science Foundation grants.. Stephen Romero, associate professor of psychology, has pledged to bicycle 200 miles in two consecutive days this summer to ...
Health,Indian researchers at the Indian Institute of Technology (IIT) Chenna...The researchers have used the Core-shell system that comprises a...The possibility of delivering therapeutic molecules into cells and...They incorporated ciprofloxacin (a known antibiotic) molecules on ... A hollow nanobubble or nanoshell of silica (10-20 nm in diameter...,Now,,Silica,Nanobubbles,for,Targeted,Drug,Delivery,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
https://doi.org/10.18632/oncotarget.23898 Bian Jang, Madhappan Santha Moorthy, Panchanathan Manivasagan, Li Xu, Kyeongeun Song, Kang Dae Lee, Minseok Kwak, Junghwan Oh, Jun-O Jin
A Canadian high school student of Indian origin has improved an ineffective experimental cancer therapy pairing it with antibiotics and has earned accolades from a panel of eminent scientists.
Enzymes are crucial for the cell metabolism and in industrial applications such as the manufacture of biosensors and medicines. A method for inactivating enzymes non-invasively and on demand could reveal the role of a biocatalyst in a particular cell function and enable fine-tuning the therapeutic dose of enzyme-based drugs. In this manuscript we introduce a universal method for inactivating enzymes with light. It consists of attaching the enzymes to photothermal nanoheaters (gold nanorods). Upon irradiation with light resonant with their LSPR the plasmonic nanoparticles generate heat, which denatures the enzymes. The resulting increase in temperature is highest in the vicinity of the nanoheaters, which allows the localized inactivation of nanorod-bound enzymes without damaging other proteins or cell membranes present in the same solution. Here we demonstrate this concept by selectively turning off an enzyme cascade via the selective inactivation of one of its components. We also prove that the ...
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Nanoshells could deliver more chemo with fewer side effects, using In vitro study verifying a method for remotely triggering release of cancer drugs
We report the development of an ultrasound bioprobe for in vitro molecular imaging. In this method, the phase of the scattered ultrasound wave is mapped to provide in vitro and intracellular imaging with nanometer-scale resolution under physiological conditions. We demonstrated the technique by successfully imaging a magnetic core in silica core shells and the stiffness image of intracellular fibers in endothelial cells that were stimulated with thrombin. The findings demonstrate a significant advancement in high-resolution ultrasound imaging of biological systems with acoustics under physiological conditions. These will open up various applications in biomedical and molecular imaging with subsurface resolution down to the nanometer scale. ...
It is now possible to remove blood clots in a less risky way, thanks to research carried out by scientists at the Institute of Medical Sciences, Banaras Hindu University, Varanasi. A team led by Prof. Debabrata Dash from the Department of Biochemistry has for the first time used photothermal therapy using near-infrared (NIR) laser and…
Performance of methods for enrichment detection on co-expression clusters. Out of the 1323 possible miRNA-cluster pairs, those with a correlation of r |
We established that melanin-based nanoshells can be used in the protection of human beings and machinery from electromagnetic radiation, in particular, from ionizing radiation, and in energy conversion such as minimizing the losses during energy transfer.
Introduction: The utility of recombinant proteins as potential therapeutics and cellular tools are largely impeded by endosome entrapment and susceptibility of delivered proteins in lysositic environments and degradative enzymes. We describe a modular, light-activated nanocarrier that transports proteins into cells by receptor-mediated endocytosis, and deliver the cargo to the cytosol by light triggered endosomal escape in a timely manner. The delivery platform is based on plasmonic hollow gold nanoshells (HGN) assembled with a cargo linking layer based on nickel affinity capable of supporting virtually any soluble poly-histidine tagged proteins. Transport into endosomes is mediated by the fusion of cell-penetrating peptides onto the protein of interest or by presenting an orthogonal internalizing handle. Once internalized, cytosolic localization of the protein of interest is achieved by excitation of nanocarriers with pulsed near-infrared (NIR) light to trigger protein release and disruption of ...
Shannon carries an extensive line of fluorescent products such as lacquer, aerosol spray cans, water base acrylic paint, varnish coatings, pigments, invisible dyes, invisible inks, re-admission ink, plastisol, enamel, fingerprint powder, pencils, adhesive additives, crayons, chalks, and fluorescent metal marking ink to name a few.. Our Phosphorescent products based on Zinc Sulfide are available in lacquer, enamel, acrylic water base, varnish, adhesive tape, plastisol and pigments.. The Super Phosphorescent line is made with Strontium long after glow and are available in acrylic water base paint, adhesive tape, plastic board, pellets, pigments, lacquer, varnish, rope, fabric, and much more.. Black lights have been a Shannon specialty since 1939. Our ultraviolet product offering contains everything from minature portable to stage spot lights. We have a black light for every need.. We are here for you so please call us and get the personal attention that you deserve! ...
Near-infrared light has better tissue penetration that is useful when the sample becomes thick," he explained. In addition to enhanced penetration -- up to 10 cm deep -- the light can be focused tightly to specific areas. Irradiation with the light released the RNA molecules from the nanoshells in the sample and initiated gene-silencing activity, which knocked down green fluorescent protein genes in the cell cluster. The experiment also showed that the irradiated cells grew at the same rate as the untreated control sample; the treated cells showed unchanged viability after irradiation.. Of course, culturing tissues consisting of related but varying cell types is a far more complex process than knocking down a single gene.. "Its a concert of orchestrated processes," said co-author and graduate student researcher Demosthenes Morales, describing the process by which human embryonic stem cells become specific tissues and organs. "Things are being turned on and turned off." Perturbing one aspect of ...
Standard optical fibre, the type now widely used in telecoms, is pretty simple in terms of design, consisting of a glass silica core surrounded by cladding material with a lower index of refraction.
A flexible StableFlex core is an improvement over a more rigid fused silica core. In addition to being a less breakable fiber, the sorbent coating will partially bond to the StableFlex, resulting in a more stable coating. For the GC analysis, a VOCOL® capillary GC column was used. Its intermediate polar nature enables strong dispersive (van der Waals forces) analyte-stationary phase interactions, along with π-π, dipole-dipole, and dipole-induced dipole interactions. The thick 1.50 μm film is necessary to provide focusing and increased retention of volatile analytes.. Slight heat, agitation of the vial, stirring, and the additional of salt are common ways to help drive volatiles into the headspace, which will increase sensitivity. The autosampler was programmed with a simple extraction (40 °C for 15 minutes with agitation). Replicates with salt (sodium chloride) added at 15% (w/v), and without salt, were extracted and analyzed for the first sample (a Kentucky bourbon). Similar ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Different types of nanoparticles - in this case, shells, rods and solid spheres - mixed together can be activated individually with pulsed laser light at different wavelengths, according to researchers at Rice University. The tuned particles plasmonic response, enhanced by nanobubbles that form at the surface, can be narrowed to a few nanometers under a spectroscope and are easily distinguishable from each other. Lapotko Group/Rice University. Advanced Materials - Transient Enhancement and Spectral Narrowing of The Photothermal Effect of Plasmonic Nanoparticles Under Pulsed Excitation. "This was the problem," Lapotko said. "All nanoparticles, beginning with solid gold colloids and moving to more sophisticated, engineered gold nanoshells, nanorods, cages and stars, have very wide spectra, typically about 100 nanometers, which means we were allowed to use only one type of nanoparticle at a time. If we tried to use different types, their spectra overlapped and we did not benefit from the high ...
Urease is found in plant seeds, bacteria, and various sea creatures. It splits urea into carbon dioxide and ammonia. Ammonia is an alkaline substance; when urease is active, the pH value on the surface of the enzyme rises. Because of the negative charge on its surface, urease has a high affinity for positively charged metal ions. In a zinc nitrate solution, the zinc ions aggregate around the urease. The local pH value on the surface of the enzyme can be finely tuned to values ideal for the formation of zinc oxide. The increasing zinc ion concentration at a suitable pH value catalyzes the formation and growth of ZnO crystals. The enzyme cores thus become surrounded by nanoshells of zinc oxide. These have a diameter of about 18 nm. By using slightly modified urease molecules, the size of the zinc oxide shells can be varied. Author: Hiroshi Matsui, Hunter College, City University of New York (USA), http://www.hunter.cuny.edu/chem/faculty_files/matsui/matsui.html. ...
Halas is one of the pioneering researchers in the field of plasmonics, creating the concept of the "tunable plasmon" and inventing a family of nanoparticles with resonances spanning the visible and infrared regions of the spectrum. She pursues fundamental studies of coupled plasmonic systems as well as applications of plasmonics in biomedicine, optoelectronics, chemical sensing, photocatalysis, and most recently in solar energy and sustainability, with solar steam technology. She is co-founder of Nanospectra Biosciences, a Houston-based company developing photothermal therapies for cancer and other diseases based on her nanoparticles, currently in multiple clinical trials, and is currently transferring other technologies from her laboratory. ...
Dr. Paul S. Russo is a Professor of Materials Science and Engineering with a joint appointment in the School of Chemistry and Biochemistry at the Georgia Institute of Technology with expertise in polymer, biopolymer and particle chemistry.. His research interests are rooted in rodlike polymers, such as plant viruses, cellulose derivatives and aromatic backbone materials. Particular emphasis has been paid to molecular transport in complex fluids containing rods and to related measurement methods. Static and dynamic laser light scattering have been joined by fluorescence photobleaching recovery and pulsed field gradient NMR spectroscopy to measure diffusion in dilute and concentrated solutions, gels, and liquid crystals. Dialysis implementations of these techniques have permitted stability studies of the amyloid protein responsible for Alzheimers disease. Other materials of interest include organophilic polypeptides, which have been coupled to silica cores to yield hybrid particles that can carry ...
Dental laser elexxion pico-LOW LEVEL LASER THERAPY. New protocols for the treatment of periodontal disease and periimplantitis. Photothermal therapy (PTT) is a pioneering alternative to standard treatment methods that is as gentle as it is effective. Due to the perio green® dye, perio green® works faster than any other method and requires the least amount of effort - powerful and gentle.
Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This schematic of a graphene liquid cell shows multiple liquid pockets containing single nanoparticles, dimers composed of dsDNA bridges in different lengths, and trimers.
This piece of amber contains the first fossilized red blood cells from a mammal ever discovered -- in this case, infected by a parasite.
Read user reviews, compare products and contact manufacturers of SNP products, including kits, typing and detection on SelectScience.
Journal of Nanomaterials is a peer-reviewed, Open Access journal that aims to bring science and applications together on nanoscale and nanostructured materials with emphasis on synthesis, processing, characterization, and applications of materials containing true nanosize dimensions or nanostructures that enable novel/enhanced properties or functions. It is directed at both academic researchers and practicing engineers. Journal of Nanomaterials will highlight the continued growth and new challenges in nanomaterials science, engineering, and nanotechnology, both for application development and for basic research. All papers should emphasize original results relating to experimental, theoretical, computational, and/or applications of nanomaterials ranging from hard (inorganic) materials, through soft (polymeric and biological) materials, to hybrid materials or nanocomposites.
Efficient plasmonic photothermal therapies (PPTTs) using non-harmful pulse laser irradiation at the near-infrared (NIR) are a highly sought goal in nanomedicine. These therapies rely on the use of plasmonic nanostructures to kill cancer cells while minimizing the applied laser power density. Cancer cells have an unsettled capacity to uptake, retain, release, and re-uptake gold nanoparticles, thus offering enormous versatility for research. In this work, we have studied such cell capabilities for nanoparticle trafficking and its impact on the effect of photothermal treatments. As our model system, we chose uveal (eye) melanoma cells, since laser-assisted eye surgery is routinely used to treat glaucoma and cataracts, or vision correction in refractive surgery. As nanostructure, we selected gold nanostars (Au NSs) due to their high photothermal efficiency at the near-infrared (NIR) region of the electromagnetic spectrum. We first investigated the photothermal effect on the basis of the dilution of Au NSs
The potential toxicity of nanoparticles currently raises many discussions in public and scientific life. The question whether nanoparticles are a threat to human health cannot be answered to complete satisfaction at the current state of knowledge. A versatile tool to investigate nanotoxicity are fluorescence microscopy and live-cell imaging as they provide excellent resolution and direct insight into cellular processes. In this work fluorescence based methods are used to investigate the influence of silica nanoparticles on human health, more precisely on the blood vessel system. At first, the synthesis and characterization of the following three different types of perylene labeled amorphous SiO 2 nanoparticle species is described: surface-labeled monodisperse particles, particles with a dye-containing silica core and a non-fluorescent silica shell and a surface-labeled nanoparticle network. The labeling of nanoparticles should not induce artificial cytotoxic effects when they are used ...
Presentation Authors: Gregory Barton*, Yang Liu, Paolo Maccarini, Gregory Palmer, Wiguins Etienne, Wei Phin Tan, Tuan Vo-Dinh, Brant Inman, Durham, NC. Introduction: We developed a novel treatment for bladder cancer (BC): a combination of gold nanoparticle-based immune- and photothermal therapy called SYMPHONY, which ablates primary tumors, induces potent anti-tumor immunity, and abscopally destroys distant metastases. Here we analyzed toxicity and biodistribution of SYMPHONY gold nanostars in murine BC models.. Methods: MB49 syngeneic bladder tumors were grown in C57BL/6 mice to 100 mm2. Tumors were treated with SYMPHONY and tissues obtained from lung, liver, brain, spleen, kidney, heart, and intestine at selected timepoints from minutes to months post-therapy. Gold nanostars (GNS) were given via tail vein injection, dosed at 20mg/kg or 80 mg/kg. We assessed toxicity multiply. First, with histopathology on necropsied tissue to assess for organ injury. Second, blood chemistries and body weight ...
Fiberguide Industries will exhibit its line of large-core multimode optical fibers featuring hard plastic clad standard silica core fibers with a nume