Page contains details about indomethacin-loaded lipid-core nanocapsules . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Lipid nanocapsules (LNCs) are biomimetic nanocarriers used for the encapsulation of a broad variety of active ingredients. Similar to surface active compounds, LNCs contain both hydrophilic and hydrophobic parts in their structure. Moreover, the components of LNCs, macrogol 15 hydroxystearate (MHS) and lecithin, are known for their surface active properties. Therefore, the aim of this paper was to investigate the capability of the LNCs to decrease surface tension using two techniques: drop tensiometry and the Wilhelmy plate method. LNCs with diameters ranging from 30 to 100 nm were successfully obtained using a phase inversion technique. The LNCs properties, such as size and zeta potential, depend on the composition. LNCs exhibit a lower limiting surface tension compared to MHS (34.8-35.0 mN/m and 37.7-38.8 mN/m, respectively), as confirmed by both drop tensiometry and the Wilhelmy plate method. LNCs have exhibited a saturated interfacial concentration (SIC) that was 10-fold higher than the critical
Lipid nanocapsules (LNCs) are extensively used as drug carrier systems, due to their small size distribution, biocompatibility and ease of preparation. They are especially useful for lipophilic drugs to overcome physicochemical constraints that limit their efficacy, such as low solubility in aqueous media. The aim of this work was to investigate the relationship between the intracellular availability of poorly soluble drugs delivered via LNCs and their biological efficacy in cells in vitro. Cyclosporin A (CsA) with a logPOct = 4.3 (Lucangioli et al., 2003) and Itraconazole (It) with a logPOct = 6.2 (Bhardwaj et al., 2013) served as model lipophilic compounds, as they are highly promising candidates for the treatment of neovascular ocular diseases. Due to their lipophilic properties and the resulting preference for the oily core of LNCs, high encapsulation efficiencies were achieved. Drug-loaded LNCs with particle sizes around 50 nm were grafted with an αvβ3 integrin ligand (RGD) to optimize ...
Page contains details about PLGA-PLL/γPGA-EboDNA nanoparticle-encapsulated microneedle patch on PVA/PVP backing layer . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Article: The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial ...
Global investment in nanotechnology research has witnessed a six fold increase during the last decade. Consequently, nanotechnology will completely revolutionize the industrial processes in the near future due to its remarkable economic potential. Some of the key drivers for the market growth include investments and breakthroughs in biomedical, pharmaceutical, electronics, molecular and diagnostic fields. Besides, these nanocapsules are being increasingly used in agrochemicals, environment and wastewater treatments, genetic engineering, consumer goods and cosmetic procedures. Some of the most advanced future applications would be nanocapsule dressings to deliver antibiotics aiding faster wound healing without invasion to the skin. These nanocapsule bandages would be consistently demanded by defence and protection forces as they need not be changed periodically. According to the experts, electronics and magnetic sector will be the largest potential market for nanocapsules, followed by ...
For proteins in general, its very difficult to cross the cell membrane. The protease will usually digest it, making stability an issue," said lead study author Yunfeng Lu, a UCLA professor of chemical and biomolecular engineering. "Here, weve been able to use this new technology to stabilize the protein, making it very easy to cross the cell membrane, allowing the protein to function properly once inside the cell. This is one of our biggest achievements ...
Viral vectors are attractive because they can be very efficient, but they are also associated with a number of safety concerns including undesirable immune responses," says Gong.. New cell targets can also require laborious alterations of viral vectors, and manufacturing tailored viral vectors can be complicated.. "It is very difficult - if not impossible - to customize many viral vectors for delivery to a specific cell or tissue in the body," Saha says.. Gongs lab coated a gene therapy payload - namely, a version of the gene-editing tool CRISPR-Cas9 with guide RNA designed in Sahas lab - with a thin polymer shell, resulting in a capsule about 25 nanometers in diameter. The surface of the nanocapsule can be decorated with functional groups such as peptides which give the nanoparticles the ability to target certain cell types.. The nanocapsule stays intact outside cells - in the bloodstream, for example - only to fall apart inside the target cell when triggered by a molecule called glutathione. ...
Glaucoma is an eye-related disease accompanied by highly elevated intraocular pressure (IOP), which causes damage to the optic nerve and results in vision loss and even blindness. Although the treatment of glaucoma with eye drops may reduce the IOP, eye drops have some limitations, such as poor patient compl
Este trabajo de investigación se realizó con apoyo financiero de los proyectos MAT2010-20370 y MAT2007-66662-C02-01 del Ministerio de Educación, Cultura y Deporte ...
Respiratory syncytial virus (RSV) is the most important cause of severe lower respiratory tract illness in infants and the elderly. Currently, no safe and effic...
A supramolecular nanocapsule was constructed by the ternary host-guest complexation of azobenzene (Azo) and methylviologen (MV) to cucurbit[8]uril (CB[8]) and the subsequent self-assembly. The supramolecular nanocapsule with both glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities can mimi Cucurbiturils and related cavitands
A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.
1. Ordered and Kinetically Discrete Sequential Protein Release from Biodegradable Thin Films. Hsu BB, Jamieson KS, Hagerman SR, Holler E, Ljubimova JY, Hammond PT. Angew Chem Int Ed Engl. pubmed:24938739; doi:10.1002/anie.201403702. 2. Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles. Eltoukhy AA, Sahay G, Cunningham JM, Anderson DG. ACS Nano. pubmed:25010491; doi:10.1021/nn501630h. 3. Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment. Hook AL, Chang CY, Scurr DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. Adv Healthc Mater. pubmed:24497458; doi:10.1002/adhm.201300518. 4. Insights into Human Glycan Receptor conformation of 1918 Pandemic Haemagglutinin-Glycan Complexes derived from NMR and MD studies. Elli S, Macchi E, Rudd TR, Raman R, Sassaki GL, Viswanathan K, Yates EA, Shriver Z, Naggi A, Torri G, Sasisekharan R, Guerrini M. Biochemistry. pubmed:24878075; doi:10.1021/bi500338r. 5. Design of Lipid Nanocapsule ...
A artrite reumatóide (AR) é uma doença auto-imune, conhecida pela inflamação da sinóvia, principalmente nas pequenas articulações das mãos e os pes. A progressão da AR leva à perda da função das articulações e, se não tratada, à deformidade das articulações afetadas. A principal causa da AR ainda é desconhecida, mas alguns mecanismos de patogênese foram identificados, como a expressão do antígeno leucocitário humano HLA-DR4, linfócitos T auto-antígenos e auto-anticorpos expressos pelos linfócitos B. Este mecanismo é o alvo do tratamento. Os produtos farmacêuticos atuais usados para o tratamento da AR são medicamentos anti-reumáticos modificadores de doença (DMARDs), DMARDs biológicos e anti-inflamatórios não esteroides (AINEs). Todos esses produtos farmacêuticos causam toxicidade quando usados por um longo período de tempo e têm grandes efeitos adversos nos pacientes. Os efeitos adversos são devidos à baixa especificidade que eles têm para os tecidos ...
HIV-1 envelope glycoprotein (Glycoprotein 120, gp120) can directly stimulate primary sensory afferent neurons and cause chronic neuropathic pain. The P2X3 receptor in the dorsal root ganglia (DRG) is associated with the transmission of neuropathic pain. Curcumin isolated from the herb Curcuma rhizome has anti-inflammatory and anti-tumor effects. The water solubility, targeting and bioavailability of curcumin can be improved by nanoparticle encapsulation. In this study, we sought to explore the effects of nanoparticle-encapsulated curcumin (nano curcumin) on HIV-gp120-induced neuropathic pain mediated by the P2X3 receptor in DRG neurons. The results showed that mechanical and thermal hyperalgesia in rats treated with gp120 were increased compared to those in the control group. The expression levels of P2X3 mRNA and protein in rats treated with gp120 were higher than those in the control group. Nano curcumin treatment decreased mechanical hyperalgesia and thermal hyperalgesia and upregulated the ...
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Preparation and characterization of tetrandrine-phospholipid complex loaded lipid nanocapsules as potential oral carriers Yi-qing Zhao, Li-ping Wang, Chao Ma, Kun Zhao, Ying Liu, Nian-ping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleâ s Republic of ChinaBackground: Tetrandrine is an active constituent that is extracted from the root tuber of the Chinese herb Stephania tetrandra S. Moore. It has shown various pharmacological effects, such as antitumor activity, multidrug resistance reversal, and hepatic fibrosis resistance. In clinical applications, it has been used to treat hypertension, pneumosilicosis, and lung cancer. However, the poor water solubility of tetrandrine has limited its application. In this study, a newly emerging oral drug carrier of phospholipid complex loaded lipid nanocapsules was developed to improve the oral bioavailability of tetrandrine.Methods: The phospholipid complex was prepared with the solvent-evaporation method to enhance
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Pregnancy complications associated with chronic fetal hypoxia have been linked to the development of adult cardiovascular disease in the offspring. Prenatal hypoxia has been shown to increase placental oxidative stress and impair placental function in a sex-specific manner, thereby affecting fetal development. As oxidative stress is central to placental dysfunction, we developed a placenta-targeted treatment strategy using the antioxidant MitoQ encapsulated into nanoparticles (nMitoQ) to reduce placental oxidative/nitrosative stress and improve placental function without direct drug exposure to the fetus in order to avoid off-target effects during development. We hypothesized that, in a rat model of prenatal hypoxia, nMitoQ prevents hypoxia-induced placental oxidative/nitrosative stress, promotes angiogenesis, improves placental morphology, and ultimately improves fetal oxygenation. Additionally, we assessed whether there were sex differences in the effectiveness of nMitoQ treatment. Pregnant ...
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Minocycline Hydrochloride USP is a tetracycline antibiotic that is used to fight bacteria in the body of cats, dogs and horses. It is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others. do ...
Nanoparticle encapsulation drug delivery systems have inspired a number of companies to use the technology to release smells. Quest s top-secret formulation will allow fragrances to cling to fabric and not be washed away with unwanted oil and dirt. Source: ...
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TY - JOUR. T1 - Everolimus Nanoformulation in Biological Nanoparticles Increases Drug Responsiveness in Resistant and Low-Responsive Breast Cancer Cell Lines. AU - Bonizzi, Arianna. AU - Truffi, Marta. AU - Sevieri, Marta. AU - Allevi, Raffaele. AU - Sitia, Leopoldo. AU - Ottria, Roberta. AU - Sorrentino, Luca. AU - Sottani, Cristina. AU - Negri, Sara. AU - Grignani, Elena. AU - Mazzucchelli, Serena. AU - Corsi, Fabio. PY - 2019/8/2. Y1 - 2019/8/2. N2 - Everolimus (Eve) is an FDA approved drug that inhibits mammalian target of rapamycin (mTOR). It is employed in breast cancer treatment even if its responsiveness is controversial. In an attempt to increase Eve effectiveness, we have developed a novel Eve nanoformulation exploiting H-ferritin nanocages (HEve) to improve its subcellular delivery. We took advantage of the natural tumor targeting of H-Ferritin, which is mediated by the transferrin receptor-1 (TfR1). Breast cancer cells overexpressing TfR-1 were successfully recognized by H-Ferritin, ...
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BEVILACQUA, Luiz; GALEAO, Augusto C.N.R. and COSTA, Flavio P.. A new analytical formulation of retention effects on particle diffusion processes. An. Acad. Bras. Ciênc. [online]. 2011, vol.83, n.4, pp.1443-1464. Epub Sep 30, 2011. ISSN 0001-3765. http://dx.doi.org/10.1590/S0001-37652011005000033.. The ultimate purpose of this paper is to present a new analytical formulation to simulate diffusion with retention in a reactive medium under stable thermodynamic conditions. The analysis of diffusion with retention in a continuum medium is developed after the solution of an equivalent problem using a discrete approach. The new law may be interpreted as the reduction of all diffusion processes with retention to a unifying phenomenon that can adequately simulate the retention effect namely a circulatory motion. It is remarkable that the governing equation requires a fourth order differential term as suggested by the discrete approach. The relative fraction of diffusion particles β is introduced as a ...
Highlights: • T-oligo induces cell cycle arrest, senescence, apoptosis, and differentiation in CRC. • Treatment with T-oligo downregulates telomere-associated proteins. • T-oligo combined with an EGFR-TKI additively inhibits cellular proliferation. • T-oligo has potential as an effective therapeutic agent for CRC. - Abstract: In the United States, there will be an estimated 96,830 new cases of colorectal cancer (CRC) and 50,310 deaths in 2014. CRC is often detected at late stages of the disease, at which point there is no effective chemotherapy. Thus, there is an urgent need for effective novel therapies that have minimal effects on normal cells. T-oligo, an oligonucleotide homologous to the 3′-telomere overhang, induces potent DNA damage responses in multiple malignant cell types, however, its efficacy in CRC has not been studied. This is the first investigation demonstrating T-oligo-induced anticancer effects in two CRC cell lines, HT-29 and LoVo, which are highly resistant to ...
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Ok ladies, we should open a forum on suet? just kidding - but, yes, Kallen I followed Zicks recipe and even added extra birdseed - but now that I know how it works, I think it will be better next time. I remember the old people talk about putting beef suet out for the birds when I was a kid. One more thought (question) I didnt think suet was necessary in the summer? Thank you for sharing your experience with me! Its such a help! ...
Ok ladies, we should open a forum on suet? just kidding - but, yes, Kallen I followed Zicks recipe and even added extra birdseed - but now that I know how it works, I think it will be better next time. I remember the old people talk about putting beef suet out for the birds when I was a kid. One more thought (question) I didnt think suet was necessary in the summer? Thank you for sharing your experience with me! Its such a help! ...
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A 63-year-old woman presented with a nontransmural MI. Coronary angiography revealed a complex hazy ulcerated culprit lesion in the mid-right coronary artery (Fig. 5A, arrows). The case was performed 5 years before the availability of NIRS. Balloon angioplasty was complicated by severe coronary no-reflow. A stent was placed with an acceptable angiographic result at the lesion site (Fig. 5B, black arrows), but with further exacerbation of severe no-reflow distally (Fig. 5B, white arrows). Arteriolar vasodilators were administered which improved epicardial coronary flow. However, there was a myocardial blush grade score of 0 to 1 with profound and persistent hypotension refractory to all measures including aggressive intracoronary pharmacologic treatment, intra-aortic balloon pump support, and parenteral pressor support. The patient died from refractory hypotension and shock 36 h after the coronary intervention. At autopsy, histopathologic analysis revealed extensive cholesterol emboli plugging ...
10 Feb 2016. In one of the first efforts to date to apply nanotechnology to targeted cancer therapeutics, researchers have created a nanoparticle formulation of a cancer drug that is both effective and nontoxic -- qualities harder to achieve with the free drug.. Their nanoparticle creation releases the potent but toxic targeted cancer drug directly to tumours, while sparing healthy tissue.. The findings in rodents with human tumours have helped launch clinical trials of the nanoparticle-encapsulated version of the drug, which are currently underway.. Aurora kinase inhibitors are molecularly targeted agents that disrupt cancers cell cycle.. While effective, the inhibitors have proven highly toxic to patients and have stalled in late-stage trials.. Development of several other targeted cancer drugs has been abandoned because of unacceptable toxicity.. To improve drug safety and efficacy, Susan Ashton and colleagues designed polymeric nanoparticles called Accurins to deliver an Aurora kinase B ...
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Aphios is enhancing the oral bioavailability of therapeutic proteins by encapsulating protein macromolecules and nanoparticles in biodegradable polymer nanospheres," says Dr. Trevor P. Castor, President & CEO, Aphios Corporation. Nanoencapsulation is being used to protect the protein macromolecules/nanoparticles during the stomach passage; the residence time in the stomach will be short compared to the protein release rate from the polymer nanospheres. Animal data demonstrates that insulin, a labile peptide, being nanoencapsulated was protected in the stomach and then transported to the blood. When protein nanoparticles reach the gut, they are transported across the lining, which may be mediated by M cells in the lymphatic tissue of the gut. Alternatively, the protein can be mobilized from nanospheres and rapidly transported to systemic circulation by the epithelial cells. Both the polymer "shell" and the protein macromolecules/nanoparticles are intended to enable and regulate this stage of drug ...
Pharmaceutical nanoparticle product development support through expert analysis and characterisation services for drug delivery or diagnostic applications. Nanoparticles are being developed for a range of healthcare product applications including drug delivery, controlled release systems and medical devices. These products present multiple challenges for product characterisation that require sophisticated analytical techniques operated by experienced analysts. Intertek provides a comprehensive R&D or Good Manufacturing Practice (cGMP) compliant analytical capability for nano-sized systems for both particles or suspensions.. Application in healthcare products include nanoencapsulation of active ingredients (APIs), liposome nanoemulsions for drug delivery or dispersed metallic nanoparticulate systems applied to diagnostics applications. Bringing quality and safety to life, we offer Total Quality Assurance expertise to help you to meet and exceed quality, safety and regulatory standards. Intertek ...
GREEN SYNTHESIS. Atom Economy: a Challenge for Enhanced Synthetic Efficiency. Evaluating the Greenness of Synthesis. Alternative Feedstocks for Synthesis. Synthesis in Green Solvents. Development and Application of Isocyanide-based Multicomponent Reactions. Flow Syntheses. Synthesis Without Protecting Groups. Biological Synthesis of Pharmaceuticals. Syntheses via C-H Bond Functionalizations. Synthesis Without Metals. Chemistry Beyond Functional Group Transformation. Synthesis Assisted by Electricity. Parameterization and Tracking of Optimization of Synthesis Strategy Using Computer Spreadsheet Algorithms. GREEN NANOSCIENCE. Formation of Nanoparticles Assisted by Ionic Liquids. CO2-Expanded Liquids for Nanoparticle Processing. Green Synthesis and Applications of Magnetic Nanoparticles. Photocatalysis by Nanostructured TiO2-based Semiconductors. Nanoencapsulation for Process Intensification. Formation of Nanoemulsions by Low-Energy Methods and Their Use as Templates for the Preparation of ...
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Fortunately, todays suet cakes and plugs are rendered, or melted repeatedly, to remove impurities and raise the melting point. Todays processed suet products typically wont melt until temperatures are consistently above 90 degrees Fahrenheit. No melt formula suet is mixed with grain, cornmeal or seeds to bind the cake together. These may also be called suet dough.. Other precautions can be taken to safely provide suet for warm weather birds. First of all, place the feeder in a cool, shady area. It is preferable to receive that shade later in the day when temperatures are higher. Add a baffle or cover to provide shade. Secondly, portion suet cakes or plugs out in halves or thirds so that you only put out what the birds will eat in a day. Another trick is to freeze the suet. A hard cake will not put off birds because the edges will soften first while the center stays frozen. Finally, use a tray to catch drips for easier clean up and to preserve hard surfaces and plants under the ...