Fomin, Victor P., Blair E. Cox, and R. Ann Word. Effect of progesterone on intracellular Ca21 homeostasis in human myometrial smooth muscle cells. Am. J. Physiol. 276 (Cell Physiol. 45): C379-C385, 1999.-Although it is well known that progesterone alters uterine contractility and plays an important role in maintenance of pregnancy, the biochemical mechanisms by which progesterone alters uterine contractility in human gestation are less clear. In this investigation we sought to identify progesterone-induced adaptations in human myometrial smooth muscle cells that may alter Ca21 signaling in response to contractile agents. Cells were treated with vehicle or the progesterone analog medroxyprogesterone acetate (MPA) for 5 days, and intracellular free Ca21 concentration ([Ca]i) was quantified after treatment with oxytocin (OX) or endothelin (ET)-1. OXand ET-1-induced increases in [Ca]i were significantly attenuated in cells pretreated with MPA in a dose-dependent manner. Progesterone receptor antagonists
Lipids havepreviously been considered primarily as building blocks of the cell membrane, but are now also recognized as important cell signaling molecules. Lysophosphatidic acid (LPA) is a glycerophospholipid consisting of a phosphate head group, a linker region, and a lipophilic tail. LPA has earlier been shown to exert a diversity of cellular effects such as aggregation, apoptosis, contraction, migration, and proliferation. The effects of LPA are elicited by activation of its cognate G protein-coupled receptors LPA1, LPA2, and LPA3. In the present study we have used cultures of human smooth muscle cells (SMCs) and erythroleukemia cells (HEL), and isolated human platelets to characterize physiological effects of LPA compared with adrenaline and noradrenaline as well as structure-activity relationships of LPA. SMCs were isolated from biopsies of human myometrium obtained at cesarean sections. We show that cultured myometrial SMCs express multiple LPA and α2-adrenergic receptor subtypes. ...
Recent studies show that EET and 20-HETE have important biological effects, particularly in the vascular system. The investigators studied the effect of eicosanoids on the gravid rat uterus. The results suggest that 20-HETE had an tocolytics effect on gravid uterus. In the previous study, we demonstrated that the enzymes of the pathway of EET were present in human uterine tissues. Moreover, the addition of an inhibitor of degradation of EET had an tocolytic effect on the human myometrium, as the exogenous addition of 8.9, 14,15-EET and 20-HETE.. Objectives:. Primary objective: To compare the balance of different metabolic pathways of arachidonic acid (AA) of the pregnant human myometrium in pathological situations (preterm labor, uterine atony, prolonged pregnancy).. Specific objectives: i) To study the effect of derived from the AA on in vitro contractile activity of normal and pathological uterine tissues, and ii) detect and quantify the different sub-products of metabolism of AA in the ...
The myometrium is the middle layer of the uterine wall, consisting mainly of uterine smooth muscle cells (also called uterine myocytes), but also of supporting stromal and vascular tissue. Its main function is to induce uterine contractions. The myometrium is located between the endometrium (the inner layer of the uterine wall), and the serosa or perimetrium (the outer uterine layer). Myometrium has 3 layers: outer longitudinal smooth muscles, middle crisscrossing (figure of eight) muscle fibres, and inner circular fibres. Middle crisscross fibres act as living ligature during involution of the uterus and prevent blood loss. The inner one-third of the myometrium (termed the junctional or sub-endometrial layer) appears to be derived from the Müllerian duct, while the outer, more predominant layer of the myometrium appears to originate from non-Müllerian tissue, and is the major contractile tissue during parturition and abortion. The junctional layer appears to function like a circular muscle ...
TY - JOUR. T1 - Importance of calcium for the stimulant action of norepinephrine and acetylcholine on the guinea pig myometrium. AU - Szurszewski, J. H.. AU - Lambert, E. H.. PY - 1973. Y1 - 1973. N2 - The results to be described were obtained from the myometrium of immature guinea pigs which had been treated by daily injections of 5 μg estradiol for 8 days. The double sucrose gap was used to record changes in membrane potential, membrane resistance and isometric tension. In Krebs solution after the initial α stimulatory effect of norepinephrine (NE), there was an increase in the force of the phasic contraction which was unaccompanied by depolarization or increase in spike frequency. This positive inotropic response to NE was observed in K free solution, Na free solution, and Cl deficient solution. Since Ca 2+ carries the current for the evoked spike, these results suggest that NE increases the inward Ca 2+ current carried by the voltage dependent channels. In K depolarizing solution, Cl ...
Progestin withdrawal is a crucial event for the onset of labor in many mammalian species. However, in humans the mechanism of a functional progestin withdrawal is unclear, because progestin concentrations do not drop in maternal plasma preceding labor. We report the presence of two novel functional membrane progestin receptors (mPRs), mPRalpha and mPRbeta, in human myometrium that are differentially modulated during labor and by steroids in vitro. The mPRs are coupled to inhibitory G proteins, resulting in a decline in cAMP levels and increased phosphorylation of myosin light chain, both of which facilitate myometrial contraction. Activation of mPRs leads to transactivation of PR-B, the first evidence for cross-talk between membrane and nuclear PRs. Progesterone activation of the mPRs leads also to a decrease of the steroid receptor coactivator 2. Our data indicate the presence of a novel signaling pathway mediated by mPRs that may result in a functional progestin withdrawal, shifting the balance from a
BioAssay record AID 314838 submitted by ChEMBL: Induction of contraction per minute in beta-estradiol stimulated rat myometrium at 0.6 uM.
The present study provided the first evidence that exogenous S1P and SphK contribute to myometrial contraction in rat myometrium. The sphingolipid mediator S1P stimulates contraction via a mechanism insensitive to PTX treatment. This observation led us to rule out the involvement of S1P 1, 4, and 5 receptors coupled only to the Gi family (55). It has been reported that S1P3 receptors are preferentially coupled to PLC activation compared with S1P2 receptors (55). In rat myometrium, S1P failed to activate PLC, suggesting that the contractile effect of S1P may be mediated via S1P2 receptors. Consistent with this interpretation, phosphorylated FTY720, which interacts with all S1P receptors except S1P2 (31, 50), failed to affect the uterine contraction. Additionally, our data demonstrated that S1P2 receptors are expressed in rat myometrial membrane and their downregulation was associated with a marked reduction in the contractile effect of S1P. The regulation of smooth muscle contraction by S1P2 ...
Principal Investigator:KAWARABAYASHI Tatsuhiko, Project Period (FY):1994 - 1996, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Obstetrics and gynecology
Background: The prevalence of obesity substantially increases in pregnant women. Maternal obesity is associated with adverse maternal and neonatal outcomes. The increased risk for cesarean section present in obese women has been related to potential impaired uterine contractility. The mechanism that underlies this theory is not clear. In vitro studies have shown that leptin, produced by adipose tissue and the placenta, exerts an inhibitory effect on myometrial contractility. The aim of this thesis was to evaluate the labor process in relation to maternal body mass index (BMI) and the clinical role of leptin in this process.. Material and Methods: Studies I-IV are cohort studies. The first two studies analyze the association between labor duration and maternal BMI based on data from the Perinatal Revision South register and the Swedish Pregnancy Register. Study I included 63,829 nulliparous women with a spontaneous onset of labor between 1995 and 2009. Study II included 15,259 nulliparous women ...
Question - Ultrasound report showed anteverted uterus, heterogenous myometrium echotexture, Hypoechoic lesion. Suggest?. Ask a Doctor about Myometrium, Ask an OBGYN, Gynecologic Oncology
OBJECTIVE: The role of diacylglycerol in the phosphatidylinositol-signaling pathway is to activate protein kinase C. In the myometrium, protein kinase C activation leads to inhibition of phasic contractions. These studies are designed to determine wh
The transition of the human uterus from a quiescent to a contractile state takes place over a number of weeks. On such biological time scales, cellular phenotype is modified by changes in the transcriptome, which in turn is under the control of the underlying endocrine, paracrine, and biophysical processes resulting from the ongoing pregnancy. In this study, we characterize the transition of the human myometrial transcriptome at term from not in labour (NIL) to in labour (LAB) using high throughput RNA sequencing (RNA-seq). RNA was isolated from the myometrium of uterine biopsies from patients at term who were not in labour (n = 5) and at term in spontaneous labour (n = 5) without augmentation. A total of 143.6 million separate reads were sequenced, achieving, on average, ∼13 times coverage of the expressed human transcriptome per sample. Principal component analysis indicated that the NIL and LAB transcriptomes could be distinguished as two distinct clusters. A comparison of the NIL and LAB ...
GenePORTER 2 Citations - Cell Line Cell Type Source Genlantis Product Citation 3T3-L1 Embryo Swiss Mouse GenePORTER 2 Transfection Reagent Sekimoto, H., Eipper-Mains, J., Pond-Tor, S. and Boney, C.M. (2005) αvβ3 Integrins and Pyk2 Mediate Insulin-Like Growth Factor I Activation of Src and Mitogen-Activated Protein Kinase in 3T3-L1 Cells. Mol. Endocrinol. 19: 1859 - 1867. A549 Lung Carcinoma Human GenePORTER 2 Transfection Reagent Alcorn, M.J., Booth, J.L., Coggeshall, K.M., Metcalf, J.P. (2001) Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2. J.Virology 75: 6450-59. AD293 Embryonic Kidney Human GenePORTER 2 Transfection Reagent Zhong, M., Murtazina, D.A., Phillips, J., Ku, C-Y and Sanborn, B.M. (2008) Multiple Signals Regulate Phospholipase CBeta3 in Human Myometrial Cells. Biol Reprod. 78: 1007 - 1017 alpha-T3 Pituitary Mouse GenePORTER 2 Transfection Reagent Feng, J., Lawson, M.A. and Melamed, P. (2008) A
Binding isotherms of oxytocin to sheep myometrial cells in a short-term cell culture were investigated in the presence of Mg2+ in the concentration range 0-10 mM. The occurrence of at least three binding sites had been demonstrated earlier. Mg2+ influences individual sites and individual features of the binding isotherm differently. Dissociation constants (Kd) of the high- and medium-affinity sites attain a minimum of 6.8 x 10(-10) and 4.2 x 10(-8) mol/l respectively at 2.75 mM-Mg2+. The two sites display the highest binding capacity (B) at 1 mM-Mg2+ (ratio of high affinity/medium affinity is 1:16). The B/Kd quotients reflecting relative binding (bound-to-free concentration) at the half-saturation of binding sites also have their maxima at 1 mM-Mg2+. The high-affinity site displays a strong positive co-operativity (Hill coefficient at 4 mM-Mg2+ of 2.4), which is amplified in the presence of Mg2+. Positive co-operativity of the medium-affinity site is markedly lower (Hill coefficient at 4 mM-Mg2+ ...
Question - Difficulty in conceiving, USS showed bulky uterus, irregular uterine outline, no cysts, myometrium with solid masses. What should be done?. Ask a Doctor about Uterus, Ask an OBGYN, Gynecologic Oncology
Because of their myorelaxant properties, we first examined their expression in human myometrium and uncover an increased expression of one specific isoform, PDE4B2, in the near-term myometrium as compared to myometrium in the nonpregnant state ...
Nitric oxide induced polarization of myometrium cells plasmalemma revealed by application of fluorescent dye 3,3′-dihexyloxacarbocyanine
The resting membrane potential (Vrest) of uterine smooth muscle has been recorded to be between -35 and -80 mV.[1] As with the resting membrane potential of other cell types, it is maintained by a Na+/K+ pump that causes a higher concentration of Na+ ions in the extracellular space than in the intracellular space, and a higher concentration of K+ ions in the intracellular space than in the extracellular space. Subsequently, having K+ channels open to a higher degree than Na+ channels results in an overall efflux of positive ions, resulting in a negative potential.. This resting potential undergoes rhythmic oscillations, which have been termed slow waves, and reflect intrinsic activity of slow wave potentials.[1] These slow waves are caused by changes in the distribution of Ca2+, Na+, K+ and Cl− ions between the intracellular and extracellular spaces, which, in turn, reflects the permeability of the plasma membrane to each of those ions.[1] K+ is the major ion responsible for such changes in ...
Because the body experiences considerable environmental diversity (eg, normal and pathological conditions), the same cell type can exhibit different characteristics and behaviors in different regions and circumstances. Thus, macrophages and neutrophils (both of which are phagocytic defense cells) will shift from oxidative metabolism to glycolysis in an anoxic, inflammatory environment. Cells that appear to be structurally similar may react in different ways because they have different families of receptors for signaling molecules (such as hormones and extracellular matrix macromolecules). For example, because of their diverse library of receptors, breast fibroblasts and uterine smooth muscle cells are exceptionally sensitive to female sex hormones. ...
Muscular middle layer of uterine wall composed of smooth muscle fibres arranged in three layers: the outer which continues through the fallopian tubes,
γ-aminobutyric acid (GABA) mediates its physiological effects through the GABAA and GABAB receptors. In this study the putative expression of GABAAR and GABABR subunits in human myometrium tissue was investigated.The expression levels of the 19 GABAAR subunits (α₁-α₆, β₁-β₃, γ₁-γ₃, δ, ε, π, θ, ρ₁-ρ₃) and the three GABABR subunits (GABAB₁ₐ, GABAB₁b, GABAB₂) were characterized by RT-qPCR analysis on ...
KEY POINTS: Obesity during pregnancy and childbirth is associated with labour dystocia leading to instrumental or operative delivery, but the underlying pathophysiological mechanisms remain unclear and insufficient uterine contractility has been suggested. This study examined whether reduced myometrial mitochondrial capacity or quantity could contribute as a pathophysiological mechanism to labour dystocia. Data did not support reduced myometrial mitochondrial capacity or quantity in the myometrium at term in obese women, but a reduced myocyte density with increased triglyceride content was demonstrated, which could lead to poorer uterine contractility. These results add to the understanding of systemic effects of obesity, placing also the myometrium at term as an affected non-adipose tissue.. ABSTRACT: Obesity is known to increase the risk of labour dystocia and insufficient energy supply, due to reduced mitochondrial capacity or quantity, could be a possible mechanism leading to reduced ...
Development of myometrium in young female rats was stimulated by administration of diethylstilboestrol. Plasma membrane and sarcoplasmic reticulum from rat myometrium were separated by a new and rapid method using a Percoll gradient. Calcium uptake was inhibited in plasma membrane vesicles isolated from oxytocin-treated myometrium, while no consistent effect of oxytocin was found on the Ca2+ uptake in the sarcoplasmic reticulum. Oxytocin regulated the plasma membrane Ca2+ pump by decreasing its apparent affinity for Ca2+ without affecting its maximal velocity. The K1/2 for Ca2+ in the absence of calmodulin was 0.41 +/- 0.04 microM in normal membranes; this was increased to 0.93 +/- 0.12 microM in oxytocin-treated membranes. Calmodulin decreased the K1/2 for Ca2+ to 0.27 +/- 0.027 microM and oxytocin also increased this, to 0.46 +/- 0.061 microM. The effect of oxytocin on the plasma membrane Ca2+ pump was highly dependent on the hormonal status of the animals. When the diethylstilboestrol was ...
Dysfunctional prostanoid and oxytocin receptors have been implicated in the development of myometrial hyperactivity, causing dysmenorrhoea and infertility. The aim of the present study was to investigate the topographical differences in functional contractile PG and oxytocin receptors in mid-cycle isolated myometrium.. Longitudinal, full-thickness sections of the anterior uterus were obtained from consenting pre-menopausal donors (aged 39 48 years) undergoing hysterectomy for benign disorders. Approval for this study was obtained from the Local Regional Ethics Committees. Specimens were harvested at the follicular stage of the menstrual cycle (n=14) and myometrial strips were dissected from lower and fundus ends. For contraction recordings, individual strips were mounted in organ baths under physiological conditions and attached to isometric force transducers. Following tissue equilibration, myogenic responses to vehicle (saline), sulprostone (an EP3/1 agonist), PGF2α, U46619 (10−9 M 10−5 ...
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Saturable high and low affinity binding sites for [3H]saxitoxin were identified in myometrial membranes of pregnant rats, with dissociation constants of 0.53 and 27 nM, respectively. The maximal binding capacity of the low affinity binding sites was about 10 times higher than that of the high affinity binding sites. The dissociation constants obtained from association and dissociation kinetics of [3H]saxitoxin were similar to those obtained from equilibrium binding. Saxitoxin and tetrodotoxin specifically displaced [3H]saxitoxin binding at both types of sites. Isradipine (1-10 microM) and amiloride (50-100 microM) were without effect on the binding of [3H]saxitoxin. At high concentrations (10-100 microM), veratridine induced a partial inhibition of [3H]saxitoxin binding. In dispersed myometrial cells, [3H]saxitoxin binding revealed the presence of both high and low affinity binding sites, with KD values similar to those obtained in myometrial membranes. Sodium currents were studied in both ...
A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed in order to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that ...
CORRIGENDUM FOR Role of Activin-A and Myostatin and Their Signaling Pathway in Human Myometrial and Leiomyoma Cell Function. J Clin Endocrinol Metab. 2020 Jan 01;105(1): Authors: PMID: 31832677 [PubMed - in process]...
TY - JOUR. T1 - Patkány myometrium termoanalitikai vizsgálata terhesség alatt. AU - Gábor, Csík. AU - Balázs, Patzai. AU - Falkay, G.. AU - Zupkó, I.. PY - 2009. Y1 - 2009. N2 - The aim of our present study was the investigation of rat myometrium by means of differential scanning calorimetry as a function of gestational age. Some additional groups of animals were exposed to adjuvant arthritis as a model for generalized inflammation. In order to find a connection between calorimetrically determined parameters and motor activity isolated organ experiments were performed and spontaneous as well as KCl-stimulated contractility were recorded. Uterine rings from the 5th day of early pregnancy (days 3-6) exhibited a maximum motor activity. A close correlation was revealed between calorimetric enthalpy (ΔH value) and basal and stimulated contractility. The generalized inflammation increased the maximal contractions at all tested stages (non pregnant, days 14 and 21). As gestation progressed AH ...
Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K(+) channels (TASK-2) might be one of the candidates for the regulation of uterine circular smooth muscles in mice. In this study, we tried to show the mechanisms of relaxation via TASK-2 channels in marine myometrium. Isometric contraction measurements and patch clamp technique were used to verify TASK conductance in murine myometrium. Western blot and immunehistochemical study under confocal microscopy were used to investigate molecular identity of TASK channel. In this study, we showed that TEA and 4-AP insensitive non-inactivating outward K(+) current (NIOK) may be responsible for the quiescence of murine pregnant longitudinal myometrium. The characteristics of NIOK coincided with two-pore domain acid-sensing K(+) channels (TASK-2). NIOK in the presence of K(+) channel blockers was inhibited further by TASK inhibitors
Extensive tissue remodelling occurs in the human myometrium before, during and after parturition. The aim of this study was to investigate the expression of two tissue remodelling molecules, matrix metalloproteinase 3 ...
7 Key changes in the 2009 FIGO Staging System for Endometrial Cancer Imaging type Relative to endometrium T1WI T2WI T1WI+C Relative to myometrium T1WI T2WI T1WI+C Diffusion-weighted MRI FIGO 2009 Stage IA: myometrial invasion = none OR < 50 % Stage IB: myometrial invasion ≥50 % Characteristics of endometrial cancer Isointensity Intermediate signal intensity Earlier enhancement Variable intensity Hyperintensity Less and more delayed enhancementa Hyperintensity (hypointensity on ADC map) ADC apparent diffusion coefficient, T1WI T1-weighted imaging, T1WI+C T1-weighted imaging with contrast enhancement, T2WI T2-weighted imaging a Maximum contrast between hyperintense myometrium and hypointense endometrial tumor occurs 50-120 s after contrast medium administration; this is the most important phase for accurate assessment of the depth of myometrial invasion. The presence of an intact enhancing cervical mucosa excludes stromal invasion FIGO 1988 Stage IA: myometrial invasion = none Stage IB: ...
Advanced maternal age (≥35 years) is associated with increased rates of operative delivery, stillbirth, and post-term labour induction. The physiological causes remain uncertain, although impaired myometrial function has been implicated. To investigate the hypothesis that maternal age directly influences successful parturition, we assessed the timing of birth and fetal outcome in pregnant C57BL/6J mice at 3 months (young), 5 (intermediate) months vs. 8 months (older) of age using infra-red video recording. Serum progesterone profiles, myometrium and cervix function, and mitochondrial electron transport chain complex enzymatic activities were also examined. Older pregnant mice had longer mean gestation and labour duration (P , 0.001), as well as reduced litter size (P , 0.01) vs. 3 month old mice. Older mice did not exhibit the same decline in serum progesterone concentrations as younger mice. Cervical tissues from older mice were more distensible than younger mice (P , 0.05). Oxytocin receptor ...
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation ...
Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous interpretations of data and may contribute to poor reproducibility of research. We assessed the reliability of Western blot data obtained to study human myometrial tissue proteins. We ran dilution series of protein lysates to explore the linearity of densitometry data. Proteins analysed included |i|α|/i|SMA, HSP27, ERK1/2, and GAPDH. While ideal densitometry data are directly proportional to protein abundance, our data confirm that densitometry data often deviate from this ideal, in which case they can fit nonproportional linear or hyperbolic mathematical models and can reach saturation. Nonlinear densitometry data were observed when Western blots were detected using infrared
Veja Foto de stock de Crosssection Of The Uterus Showing The Endometrium Near The Uterine Lumen The Outer Myometrium And The Lateral Broad Ligaments Tem. Encontre fotografias premium e de alta resolução na Getty Images.
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TY - JOUR. T1 - Microcirculation and intracellular free calcium changes in the pregnant uterine muscle. AU - Ruttner, Z.. AU - Ivanics, T.. AU - Kozma, F.. AU - Slaaf, D. W.. AU - Reneman, R. S.. AU - Ligeti, L.. AU - Tóth, A.. PY - 1998/3/20. Y1 - 1998/3/20. N2 - The quality of the microcirculation of the uterus is a key factor for the condition of the fetus. Presently, no model is available to study directly the in vivo microciculation of the myometrium under physiological and pathophysiological circumstances. Therefore, we present a novel model to study the microcirculation and intracellular processes in the myometrium of the close to term pregnant anesthetized rats. Pups are removed from the uterus, and a small strip of uterus is prepared free, flipped over and mounted in a superfusion chamber, leaving the radix and thereby the circulation intact. Patency of the preparation was verified with RBC velocity measurements. For fluorescence ratio measurements, Indo-1 AM was used. Fluorescence ...
Definition of uterine contraction in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is uterine contraction? Meaning of uterine contraction as a finance term. What does uterine contraction mean in finance?
There are three types of muscle in the human body. Cardiac muscle is found only in the heart. Striated muscle is voluntary and attached to our skeleton so that we can skip and dance. Smooth muscle is not voluntary, we have no conscious control over it. It is found in the walls of hollow viscera, airways, blood vessels, the iris and in hair follicles. There is no fourth category of muscle. If uterine smooth muscle was so different from other smooth muscle then it would be in a section of its own. If uterine smooth muscle was designed to cause pain when contracting, as many people believe, then it would be very different from the smooth muscle in your stomach. It is not ...
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Arachidonic acid metabolites are considered important paracrine regulators in human myometrial contractions 148 . PGF2a and PGE2 are potent pharmacological
Junctional zone is a region representing the inner myometrium and is a very important imaging feature in pelvic MR imaging for interpretation of various pathologies. In its intact state, it is usually visualised as a low T2 signal layer beneath t...
Lets talk about birth. Specifically, the prevailing belief that seems to exist in the birth community that birthing individuals MUST be upright and mobile in order for labor to progress. While I dont disagree that being upright and mobile can be beneficial to the progression of labor, laboring in the bed isnt necessarily detrimental to the progression of labor or a recipe for a cesarean either.. When we look at labor as process and how it progresses, its important to remember that there are three elements that work together. The ProDoula Childbirth Education Curriculum breaks these down into what we call the Squeeze, Squat & Squirm - The GPS of Birth©. Lets examine these a bit more in-depth below.. Squeeze - the uterus controls the intensity and the pace of the labor. Some consider the uterus the most powerful muscle in the female body. There are three layers of the uterine muscle (myometrium) and as these layers contract in response to oxytocin they contract in a clockwise motion. The ...
Free, official coding info for 2018 ICD-10-CM C54.2 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
, Human Uterus: Fundus (Normal) tissue lysate, GTX27608, Applications: ELISA, IP, WB; ELISA, Immunoprecipitation, Western Blot (WB); CrossReactivity:
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008 ...
what is the function of dopamine released from the hypothalmus|inhibition of prolactin synthesisoxytocin function|1.stimulation of uterine smooth muscle contractions2.contraction of oviduct (gamete transport)3.contraction of myoepithelial cells (milk let down)
Now, lets take another leap of thought. Think about your choices about childbirth, what assessments, monitoring and procedures your birth professional is speaking with you about, your concerns about pain, possible pain relief options and even possibly having a non-labouring birth, or your health issues that might affect your birth choices and think about your Birth Plan. When you learn the skills in The Pink Kit, you can take those skills with you into whatever birth you find yourself having. Regardless of where or with whom you will birth or whatever is happening to you or around you, you will have another contraction. If you are having a non-labouring c/s then you can use these resources to prepare for the birth of your child anyway , thus giving you a deep sense of connection to the process of childbirth. If you are going to labour and give birth, you can learn the truly universal skills, which work. Youll still be breathing, so why not learn the Directed Breathing (the most natural way ...