A myocardial perfusion scan is a type of nuclear medicine procedure. This means that a tiny amount of a radioactive substance, called a radionuclide (radiopharmaceutical or radioactive tracer), is used during the procedure to assist in the examination of the tissue under study. Specifically, the myocardial perfusion scan evaluates the hearts function and blood flow.. A radionuclide is a radioactive substance used as a "tracer," which means it travels through the blood stream and is taken up (absorbed) by the healthy heart muscle tissue. On the scan, the areas where the radionuclide has been absorbed will show up differently than the areas that do not absorb it (due to possible damage to the tissue from decreased or blocked blood flow).. A stress myocardial perfusion scan is used to assess the blood flow to the heart muscle (myocardium) when it is stressed by exercise or medication and to determine what areas of the myocardium have decreased blood flow. This is done by injecting a radionuclide ...
A myocardial perfusion scan is a type of nuclear medicine procedure. This means that a tiny amount of a radioactive substance, called a radionuclide (radiopharmaceutical or radioactive tracer), is used during the procedure to assist in the examination of the tissue under study. Specifically, the myocardial perfusion scan evaluates the hearts function and blood flow.. A radionuclide is a radioactive substance used as a "tracer," which means it travels through the blood stream and is taken up (absorbed) by the healthy heart muscle tissue. On the scan, the areas where the radionuclide has been absorbed will show up differently than the areas that do not absorb it (due to possible damage to the tissue from decreased or blocked blood flow).. A resting myocardial perfusion scan is used to assess the blood flow to the heart muscle (myocardium) and to determine what areas of the myocardium have decreased blood flow. This is done by injecting a radionuclide (thallium or technetium) into a vein in the ...
Background-The clinical analysis of myocardial dynamic computed tomography myocardial perfusion imaging lacks standardization. The objective of this prospective study was to compare different analysis approaches to diagnose ischemia in patients with stable angina referred for invasive coronary angiography. Methods and Results-Patients referred for evaluation of stable angina symptoms underwent adenosine-stress dynamic computed tomography myocardial perfusion imaging with a second-generation dual-source scanner. Quantitative perfusion parameters, such as blood flow, were calculated by parametric deconvolution for each myocardial voxel. Initially, perfusion parameters were extracted according to standard 17-segment model of the left ventricle (fully automatic analysis). These were then manually sampled by an operator (semiautomatic analysis). Areas under the receiver-operating characteristic curves of the 2 different approaches were compared. Invasive fractional flow reserve ≤0.80 or diameter ...
MINNEAPOLIS, July 13, 2015-- Vital Images, Inc. will debut its 510 FDA- cleared CT Myocardial Perfusion application at the 10 th Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography in Las Vegas, July 16-19.. Vital s CT Myocardial Perfusion was developed using feedback gathered from industry experts who also participated in the CORE...
As coronary artery disease may also occur during childhood in some specific conditions, we sought to assess the feasibility and accuracy of perfusion cardiovascular magnetic resonance (CMR) in paediatric patients. First-pass perfusion CMR studies were performed under pharmacological stress with adenosine and by using a hybrid echo-planar pulse sequence with slice-selective saturation recovery preparation. Fifty-six perfusion CMR examinations were performed in 47 patients. The median age was 12 years (1 month-18 years), and weight 42.8 kg (2.6-82 kg). General anaesthesia was required in 18 patients. Mean examination time was 67 ± 19 min. Diagnostic image quality was obtained in 54/56 examinations. In 23 cases the acquisition parameters were adapted to patients size. Perfusion CMR was abnormal in 16 examinations. The perfusion defects affected the territory of the left anterior descending coronary artery in 11, of the right coronary artery in 3, and of the circumflex coronary artery in 2 cases. Compared
Position Emission Tomography (PET) - Myocardial Perfusion Scan. PET stands for Positron Emission Tomography and is an imaging technique which uses small amount of a radioactive tracer to help in the diagnosis of heart disease.. The commonest tracer used in Rubidium-82(Rb-82 or 82Rb). 82Rb is a potassium analogue that is a generator product with a physical half-life of 76 seconds. Owing to the distinct advantage of not requiring an on-site cyclotron, 82Rb is the most widely used radioactive tracer for assessment of myocardial perfusion with PET.. The 82Rb tracer is introduced into the body by intravenous (I/V) injection directly from a small portable generator and a PET Scanner is used to produce an image showing the distribution of the tracer in the heart muscles.. Following the intravenous administration, 82Rb is carried in the blood stream and in the blood vessels supplying the heart muscles. 82Rb is then rapidly taken up by the heart muscles. 82Rb activity is noted in the heart within the ...
A resting myocardial perfusion scan in a procedure in which nuclear radiology is used to assess blood flow to the heart muscle and determine what areas have decreases blood flow.
Question - I recently had a myocardial perfusion scan and holter monitor - QY. Find the answer to this and other Medical questions on JustAnswer
TY - JOUR. T1 - Perfusion vector-a new method to quantify myocardial perfusion scintigraphy images: a simulation study with validation in patients.. AU - Minarik, David. AU - Senneby, Martin. AU - Wollmer, Per. AU - Mansten, Alva. AU - Sjöstrand, Karl. AU - Edenbrandt, Lars. AU - Trägårdh, Elin. PY - 2015. Y1 - 2015. N2 - The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective quantitative method for further assisting the visual interpretation and to test the concept using simulated MPS images as well as patients.. AB - The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce the concept of the perfusion vector as a new objective ...
Myocardial perfusion reserve (hyperemic divided by basal myocardial blood flow) describes vasodilator responsiveness of coronaryresistive vessels. The effect of aging and gender on myocardial perfusion reserve remains controversial. Methods: We studied 56 normal volunteers (21 women, 35 men; aged 50 +/- 20 yr, range 21-86 yr) with O-15-water PET to measure myocardial blood flow during basal and hyperemic stales with intravenous dipyridamole (0.56 mg/kg, n = 46) or adenosine (140 mu g/kg/min, n = 10). For comparative analysis, patients were grouped according to age: ,30 yr (n = 11), 30-49 yr (n = 18), 50-69 yr (n = 15) and greater than or equal to 70 yr (n = 12). Results: Overall, basal flow was 1.00 +/- 0.26 ml/min/g and hyperemic flow was 3.31 +/- 1.38 ml/min/g, resulting in a myocardial perfusion reserve of 3.38 +/- 1.35. There was an increase in basal flow with age (r = 0.45, p , 0.025), although hyperemic flow was only lower in patients greater than or equal to 70 yr, causing a significant ...
These programs provide various means to evaluate statistics and comparisons for series of images that stem from myocardial perfusion imaging. mia-2dmyocard-ica This program is used to run a ICA on a series of myocardial perfusion images to create sythetic references that can be used for motion correction by image registration. If the aim is to run a full motion compensation then it is better to create a segmentation set and use mia-2dmyoica-nonrigid. If the input data is given by means of a segmentation set, then on can also use mia-2dmyocard-icaseries. This program is essentially used to test different options on how to run the ICA forreference image creation.. mia-2dmyocard-icaseries This program is used to run a ICA on a series of myocardial perfusion images given in a segmentation set in order to create sythetic references that can be used for motion correction by image registration. If the aim is to run a full motion compensation then it is better run mia-2dmyoica-nonrigid, since this ...
Both ischemic and non-ischemic heart disease can cause disturbances in the myocardial blood volume (MBV), myocardial perfusion and the myocardial extracellular volume fraction (ECV). Recent studies suggest that native myocardial T1 mapping can detect changes in MBV during adenosine stress without the use of contrast agents. Furthermore, native T2 mapping could also potentially be used to quantify changes in myocardial perfusion and/or MBV. Therefore, the aim of this study was to explore the relative contributions of myocardial perfusion, MBV and ECV to native T1 and native T2 at rest and during adenosine stress in normal physiology. Healthy subjects (n = 41, 26 ± 5 years, 51% females) underwent 1.5 T cardiovascular magnetic resonance (CMR) scanning. Quantitative myocardial perfusion [ml/min/g] and MBV [%] maps were computed from first pass perfusion imaging at adenosine stress (140 microg/kg/min infusion) and rest following an intravenous contrast bolus (0.05 mmol/kg, gadobutrol). Native T1 and T2 maps
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately. The investigational drug, regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist, the receptor responsible for coronary vasodilation, and is being studied for potential use as a pharmacologic stress agent in myocardial perfusion imaging (MPI) studies. This study will compare the safety and efficacy of regadenoson to that of Adenoscan in detecting reversible myocardial perfusion defects ...
Myocardial perfusion is an imaging test. Its also called a nuclear stress test. It is done to show how well blood flows through the heart muscle. It also shows how well the heart muscle is pumping. For example, after a heart attack, it may be done to find areas of damaged heart muscle. This test may be done during rest and while you exercise.
The present study indicates that detection of early allograft vasculopathy is feasible by serial myocardial perfusion scans. Twenty episodes of vasculopathy were detected by thallium-201 scintigraphy in a prospective follow-up of 76 patients. Of the 20 episodes, 13 were not apparent on coronary angiograms, suggesting that perfusion abnormalities may precede angiographic evidence of the disease. These results differ from previous reports of myocardial perfusion scans that failed to confirm the clinical utility of the procedure (18-23). The perfusion scans in the referred studies were performed late after transplantation, after diffuse and chronic involvement of the coronary arteries had probably occurred; at this time, regional perfusion defects are not likely to be detected due to balanced ischemia in various coronary territories (18,23). In fact, 2 of the 76 patients in our cohort also did not demonstrate perfusion abnormalities despite angiographic evidence of the disease. These 2 patients ...
A myocardial perfusion scan takes images of the blood supply (or what your cardiologist may call "perfusion") to the heart muscle using a gamma camera. The blood supply is made visible to the camera by using a small amount of radioactive tracer, which is injected into an arm vein. Occasionally an alternative tracer called thallium is used.. Depending on the exact heart condition in question, the procedure may be performed at rest, with the heart under stress or most commonly both. Myocardial scans give information that is useful in diagnosing and managing conditions such as coronary artery disease, dead tissue resulting from a lack of blood supply and diseases of the heart muscle.. A stress myocardial perfusion scan examines the blood supply to the heart muscle using a gamma camera. The blood supply is made visible to the camera by using a small amount of radioactive tracer, which is injected into an arm vein. The injection is given during stress exercise on a treadmill, then again while resting ...
Prognosis in patients with suspected or known ischemic heart disease and normal myocardial perfusion: Long-term outcome and temporal risk ...
The current study extends the results of a number of previous CMR prognostic studies in stable patients with known or suspected CAD. Jahnke et al5 followed up 302 patients after normal stress CMR perfusion and reported a low event rate comparable to that previously reported with nuclear and echocardiographic techniques.4 Subsequently, Pilz et al6 extended these results in a study of 218 patients with normal CMR, reporting similar results. However, not all studies are concordant on this point.7. Although several studies reported outcomes in patients with normal versus abnormal stress perfusion CMR, with respect to incremental prognostic value, Steel et al7 recently reported the additive prognostic value of DE and stress perfusion data over pre-CMR data and each other. The results of our study are consistent with previous reports indicating that the presence and extent of myocardial delayed enhancement provides incremental prognostic value for adverse events.7,15,-,18. The current study extends ...
زمینه و هدف: بیماری های عروق کرونر موجب مرگ و میر، ناتوانی و تحمیل هزینه های زیادی می شود. ارزش تشخیصی اسکن قلب برای تنگی عروق کرونر متفاوت گزارش شده است. هدف این مطالعه بررسی ارزش تشخیصی اسکن در مقایسه با آنژیوگرافی است. روش بررسی: این مطالعه از نوع مقطعی بوده و جامعه آماری بیماران مراجعه کننده به بخش پزشکی هسته ای بیمارستان قلب ساری بودند. 115 بیمار که نتیجه آنژیوگرافی آن ها معلوم بود انتخاب شدند. داده های مربوط به عوامل خطر بیماری عروق کرونر به وسیله پرسش نامه، جمع آوری گشت. نتایج با استفاده از آزمون t و کای اسکور با SPSS و استفاده از شاخص های حساسیت و ویژگی و ...
The effects of peripheral cold exposure on myocardial perfusion and function were studied in 13 patients with scleroderma without clinically evident myocardial disease. Ten patients had at least one transient, cold-induced, myocardial perfusion defect visualized by thallium-201 scintigraphy, and 12 had reversible, cold-induced, segmental left ventricular hypokinesis by two-dimensional echocardiography. The 10 patients with transient perfusion defects all had anatomically corresponding ventricular wall motion abnormalities. No one in either of two control groups (9 normal volunteers and 7 patients with chest pain and normal coronary arteriograms) had cold-induced abnormalities. This study is the first to show the simultaneous occurrence of cold-induced abnormalities in myocardial perfusion and function in patients with scleroderma. The results suggest that cold exposure in such patients may elicit transient reflex coronary vasoconstriction resulting in reversible myocardial ischemia and ...
岡山大学審査学位論文 Heart; 100(13), 1008-1015, 2014 掲載 Author version. The final publication is available at BMJ via http://dx.doi.org/10.1136/heartjnl-2013-305468 © 2014 Kazuhiro Osawa et al., licensee BMJ Publishing Group Ltd & British Cardiovascular ...
We examined MCE to evaluate myocardial perfusion. MCE is somewhat limited when used to evaluate myocardial perfusion quantitatively, although it accurately demonstrates the area at risk ([22-25]). Quantitative evaluation of myocardial perfusion using the contrast echo technique requires use of a contrast agent that distributes bubbles of the same density and size throughout all injections and among different subjects, because the echo intensity significantly depends on bubble size and density. There are several studies presenting indexes from the time-intensity curve that are reproducible and reliable when human albumin is used as the contrast agent, bubbles are produced by a sonication method, the contrast solution has no foamy layer and the injection volume and speed are carefully set ([26-36]). Recent work ([37, 38]) has suggested that the ultrasonic power and the gas surrounding the bubbles are major factors in the disruption of bubbles, although these factors have not yet been well ...
The methods were validated and they have already been taken into use in hospitals all over the world. Coronary artery disease is the most common cause of death in the world, and a major cause of hospitalisation. Myocardial perfusion imaging (MPI), which is used to assess the sufficiency of myocardial blood flow, is an important tool in the diagnostics of coronary artery disease and in determining its severity. The scan is usually performed in two phases involving a stress myocardial perfusion imaging scan and a rest myocardial perfusion imaging scan. The patient is given an injection of a radioactive substance, which gets absorbed in those parts of the heart muscle that have normal blood flow. The scan is performed by using a gamma camera which detects radiation coming from the patient. The quality of images obtained by MPI are dependent on a variety of factors, the most significant ones being image noise, photon attenuation, Compton scattering, collimator-detector response (CDR), and patient ...
The assessment of regional myocardial perfusion using magnetic resonance (MR) imaging during the first-pass of a contrast agent bolus requires tracking of the signal time course for each myocardial segment so that a detailed perfusion map can be derived. To obtain such a map in practice, however, is not trivial because deformation of the shape of the myocardium and respiratory induced motion render a major difficulty in this process. This study describes a practical implementation of a real-time interactive MR echo-planar (EPI) myocardial perfusion imaging system and demonstrates an automated approach for motion and deformation tracking of functional myocardial perfusion images. ...
Background: Outcomes data are crucial to developing new technology. Coronary computed tomographic angiography (CTA) is rapidly gaining acceptance for assessing coronary artery disease (CAD) extent and severity. This studys aim was to compare prognosis by CTA to a matched cohort undergoing myocardial perfusion SPECT (MPS).. Methods: We prospectively enrolled 1,138 patients (pts.) referred to CTA (16 slice multidetector CT, GE Healthcare) with suspected or progressive CAD (47% intermediate likelihood [LK]), assessed with the Duke CAD index (validated angiographic score subsetting proximal, extensive, and left main CAD). This cohort was matched to 7,849 pts. undergoing MPS from which % ischemic myocardium was defined with a 20-segment model. Death from all-causes was estimated using Cox proportional hazards models adjusting for pretest LK.. Results: For CTA, 39 deaths were observed at 1.5 years of follow-up; a rate similar to MPS (annual mortality: CTA=1.16% vs.MPS=1.13%). The Duke index was ...
The aim of the study was to evaluate the contribution to moscintigraphy of myocardial perfusion (TSMP) with 99mTc-sestamibi in the management of suspected or known coronary patientss population. It included 42 patients with an average age of 57.02 ± 9.77 years with extremes ranging from 36 to 77 years. The pre-test probability in 38 patients was high in 7 patients (18.42%), intermediate in 29 patients (76.31%) and low in 2 patients (5.26%). Patients with a high pre-test probability had a positive scintigraphy. Among the 26 patients who underwent transthoracic ultrasound (TTU), 10 with normal kinetics on trans-thoracic ultrasound (TTU) had positive scintigraphy. For 16 patients with TTU abnormalities, 6 had negative scintigraphy and 10 had positive scintigraphy. The TSMP was positive for 28 patients (66.66%). Among these patients, 16 had pure ischemia, 57.14% (16/28), 7 pure necrosis (25%), and 5 both necrosis and ischemia. Myocardial perfusion scintigraphy remains a very contributory
Myocardial perfusion imaging (MPI) is a commonly used diagnostic modality for risk stratification in patients with known or suspected coronary artery
TY - JOUR. T1 - Accelerated dual-contrast first-pass perfusion MRI of the mouse heart. T2 - Development and application to diet-induced obese mice. AU - Naresh, Nivedita K.. AU - Chen, Xiao. AU - Roy, Rene J.. AU - Antkowiak, Patrick F.. AU - Annex, Brian H.. AU - Epstein, Frederick H.. PY - 2015/3/1. Y1 - 2015/3/1. N2 - Purpose: Gene-modified mice may be used to elucidate molecular mechanisms underlying abnormal myocardial blood flow (MBF). We sought to develop a quantitative myocardial perfusion imaging technique for mice and to test the hypothesis that myocardial perfusion reserve (MPR) is reduced in a mouse model of diet-induced obesity (DIO). Methods: A dual-contrast saturation-recovery sequence with ky-t undersampling and a motion-compensated compressed sensing reconstruction algorithm was developed for first-pass MRI on a small-bore 7 Tesla system. Control mice were imaged at rest and with the vasodilators ATL313 and Regadenoson (n = 6 each). In addition, we imaged mice fed a high-fat ...
OBJECTIVES: Although the prognostic value of quantitative single photon emission computed tomography myocardial perfusion imaging (MPI) with exercise and pharmacologic stress is well established, the prognostic and management value in the Medicare age population is less clear.. METHODS: The prospectively populated Cleveland Clinic nuclear cardiology database was used to identify 5,994 consecutive pateints, age ,65 years [1,664 (28%) exercise MPI, mean age 72.4±5.1, 74% male], who underwent MPI between January 2004 and January 2008. Clinical baseline variables, post test 90 days revascularization and MPI variables were analyzed. Overall and stratified nonparametric survival estimates were obtained by Kaplan-Meier method. Median follow-up time was 2.4 years. Parametric hazard modeling with bootstrap bagging methods was used to determine prognostic variables predicting mortality.. RESULTS: There was no difference in mortality in patients with an abnormal MPI vs. those with normal MPI. Amongst ...
SPECT myocardial perfusion imaging (MPI) is the most validated non-invasive method to test for ischemia, and this procedure is performed over 15 to
Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope p
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The presence of a reversible myocardial perfusion deficit as detected by the combination of adenosine perfusion and late gadolinium CMR provides excellent prognostic stratification of patients with CAD, consistent with other recent reports (10-14). In a multivariate analysis, we showed that the presence of a reversible perfusion deficit was associated with a 3-fold increased risk for death or nonfatal myocardial infarction, in accordance with another study presenting a ,3-fold increased risk (11). In contrast to the latter study, which included only 14% patients with typical, 49% with atypical angina, and one-third with nonanginal symptoms, all of our patients had anginal symptoms, representing a higher likelihood of myocardial ischemia. We showed that reversible perfusion deficit was the strongest multivariate predictor of major adverse cardiovascular events, with incremental prognostic value over other cardiovascular risk factors. We included consecutive patients with stable angina pectoris ...
Journal: EJNMMI - European Journal of Nuclear Medicine and Molecular Imaging ArticleTitle: Relationship Between Coronary Contrast-Flow Quantitative Flow Ratio and Myocardial Ischemia Assessed by SPECT MPI
Vignaux, O.; Allanore, Y.; Meune, C.; Pascal, O.; Duboc, D.; Weber, S.; Legmann, P.; Kahan, A., 2005: Evaluation of the effect of nifedipine upon myocardial perfusion and contractility using cardiac magnetic resonance imaging and tissue Doppler echocardiography in systemic sclerosis
The effect of obesity on regadenoson-induced myocardial hyperemia: a quantitative magnetic resonance imaging study. DiBella, Edward; Fluckiger, Jacob; Chen, Liyong; Kim, Tae; Pack, Nathan; Matthews, Brian; Adluru, Ganesh; Priester, Tiffany; Kuppahally, Suman; Jiji, Ronny; McGann, Chris; Litwin, Sheldon // International Journal of Cardiovascular Imaging;Aug2012, Vol. 28 Issue 6, p1435 The A2 receptor agonist, regadenoson, is increasingly used as a vasodilator during nuclear myocardial perfusion imaging. Regadenoson is administered as a single, fixed dose. Given the frequency of obesity in patients with symptoms of heart disease, it is important to know whether the fixed dose... ...
This application supports visualization, diagnostic assessment, and quantification of cardiac images focusing on the left ventricular myocardium: specifically providing quantitative myocardial blood flow measurements for CT images, including the ability to identify areas of decreased perfusion within the myocardium that may represent ischemia. The application supports axial, ECG-gated CT images, consisting of multiple time shots of the same myocardial region over time. CT Dynamic Myocardial Perfusion displays the results as a composite image (single image that is calculated from a set of time course images at a single location). ...
A myocardial perfusion is a noninvasive scan that is taken to show the amount of blood that is flowing through the heart muscles, as stated on WebMD. There are two sets of images, one taken during...
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Hypertension is one of the most important risk factors for cardiovascular disease. However, hypertension may also result in left ventricular dyssynchrony (LVD) which is characterized by delayed activation of certain ventricular segments leading to un
Patient Centered Imaging In recent years, there has been a large increase in the role of diagnostic imaging in the medical industry and with that has come increased radiation exposure. Many professional organizations have come together, including ASNC, AHA and IAC to address the issue of radiation ...
DENVER -- The use of regadenoson (Lexiscan) is safe and can lead to cost and time efficiencies in patients undergoing exercise SPECT myocardial perfusion imaging.
နှလုံးကြွက်သားသွေးရရှိမှုစစ်ဆေးခြင်းဟာ နားနေသည့်အချိန်နှင့် လှုပ်ရှားနေသည့်အချိန် နှစ်မျိုးမှာ နှလုံးကြွက်သားထဲရှိ သွေးပမာဏကိုတိုင်းခြင်းဖြစ်တယ်။ ရင်ဘတ်အောင့်ခြင်း အကြောင်းအရင်းရှာရန် အသုံးပြုလေ့ရှိပါတယ်။ ရုတ်တရက် နှလုံးဖောက်ခြင်းဖြစ်ပွားပြီးသည့်အခါတွင်လည်း နှလုံးကြွက်သားများ သွေးလုံလောက်စွာရမှုရှိမရှိ နှင့် ထိုနှလုံးဖောက်ခြင်းကြောင့် ...
PURPOSE: To assess the diagnostic performance of a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors for nuclear myocardial perfusion imaging (MPI). METHODS: The study group comprised 75 consecutive patients (55 men, BMI range 19-45 kg/m(2)) who underwent a 1-day (99m)Tc-tetrofosmin adenosine-stress/rest imaging protocol. Scanning was performed first on a conventional dual-detector SPECT gamma camera (Ventri, GE Healthcare) with a 15-min acquisition time each for stress and rest. All scans were immediately repeated on an ultrafast CZT camera (Discovery 530 NMc, GE Healthcare) with a 3-min scan time for stress and a 2-min scan time for rest. Clinical agreement (normal, ischaemia, scar) between CZT and SPECT was assessed for each patient and for each coronary territory using SPECT MPI as the reference standard. Segmental myocardial tracer uptake values (percent of maximum) using a 20-segment model and left ventricular ejection fraction (EF) ...
We aimed at establishing the optimal scan time for nuclear myocardial perfusion imaging (MPI) on an ultrafast cardiac gamma-camera using a novel cadmium-zinc-telluride (CZT) solid-state detector technology. METHODS: Twenty patients (17 male; BMI range, 21.7-35.5 kg/m(2)) underwent 1-d (99m)Tc-tetrofosmin adenosine stress and rest MPI protocols, each with a 15-min acquisition on a standard dual-detector SPECT camera. All scans were immediately repeated on an ultrafast CZT camera over a 6-min acquisition time and reconstructed from list-mode raw data to obtain scan durations of 1 min, 2 min, etc., up to a maximum of 6 min. For each of the scan durations, the segmental tracer uptake value (percentage of maximum myocardial uptake) from the CZT camera was compared by intraclass correlation with standard SPECT camera data using a 20-segment model, and clinical agreement was assessed per coronary territory. Scan durations above which no further relevant improvement in uptake correlation was found were ...
Poster: ESCR 2016 / P-0024 / Quantitative myocardial perfusion measured before and after invasive treatment using advanced CT-technology by: T. Rienmüller1, C. Baumgartner1, V. Makarenko2, V. Bereznitskiy2, I. Rychina2, P. Ourednicek3, R. Rienmüller1; 1Graz/AT, 2Moscow/RU, 3Brno/CZ
TY - JOUR. T1 - Coronary stenosis severity assessed by 256-slice MDCT angiography in comparison with stress myocardial perfusion imaging. AU - Yonezawa, Masato. AU - Higuchi, K.. AU - Yamazaki, Y.. AU - Jinnouchi, M.. AU - Maruoka, Y.. AU - Isoda, T.. AU - Kamitani, T.. AU - Baba, S.. AU - Matsuo, Y.. AU - Abe, K.. AU - Honda, H.. PY - 2012/1/10. Y1 - 2012/1/10. N2 - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the diagnostic accuracy of MDCT for detecting myocardial ischemia by 201Tl SPECT. Fifty-three patients underwent both coronary CT angiography and stress myocardial perfusion SPECT. All coronary arteries were assessable with appropriate image quality. MDCT revealed high specificity, but only half of stenotic lesion by MDCT revealed ischemia on SPECT.. AB - We evaluated the feasibility of 256-slice MDCT for detecting coronary artery stenosis without beta blocker premedication, and assessed the ...
The Combined Coronary angiography and myocardial perfusion imaging using 320 detectors computed tomography (CORE-320) was designed as a prospective, multi-center, international, blinded study designed to evaluate the diagnostic accuracy of multi-detector computed tomography using 320 detectors for identifying coronary artery luminal stenosis and corresponding myocardium perfusion defects in patients with suspected coronary artery disease. The primary analysis will be a comparison of the diagnostic capability of the combination of quantitative 320-MDCT angiography and quantitative perfusion imaging to the combination of conventional coronary angiography and SPECT myocardial perfusion imaging at the patient level. A positive patient will be defined as having at least one vessel with a ≥ 50% diameter stenosis defined by quantitative coronary angiography and a corresponding positive SPECT territorial myocardial perfusion defect ...
TY - JOUR. T1 - Cardiac contraction motion compensation in gated myocardial perfusion SPECT. T2 - A comparative study. AU - Salehi, Narges. AU - Rahmim, Arman. AU - Fatemizadeh, Emad. AU - Akbarzadeh, Afshin. AU - Farahani, Mohammad Hossein. AU - Farzanefar, Saeed. AU - Ay, Mohammad Reza. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Introduction: Cardiac contraction significantly degrades quality and quantitative accuracy of gated myocardial perfusion SPECT (MPS) images. In this study, we aimed to explore different techniques in motion-compensated temporal processing of MPS images and their impact on image quality and quantitative accuracy. Material and method: 50 patients without known heart condition underwent gated MPS. 3D motion compensation methods using Motion Freezing by Cedars Sinai (MF), Log-domain Diffeomorphic Demons (LDD) and Free-Form Deformation (FFD) were applied to warp all image phases to fit the end-diastolic (ED) phase. Afterwards, myocardial wall thickness, myocardial to blood pool ...
Technetium-labeled agents, which are most often used for assessing myocardial perfusion in myocardial perfusion scintigraphy (MPS), are cleared by the liver and excreted by the biliary system. Spillover from extra-cardiac activity into the myocardium, especially the inferior wall, might conceal defects and lower the diagnostic accuracy of the study. The objective was to determine rules of thumb for when reacquisition is useful due to high extra-cardiac uptake, i.e., when interpretation of the studies was affected by poor image quality. Patients admitted to MPS at any of the three study sites, who also underwent a reacquisition due to high extra-cardiac uptake were included. Image quality was assessed by ten technologists on a scale ranging from 1 to 5. Interpretations regarding the presence/absence of ischemia/infarction, including the certainty of the diagnosis, were made by three physicians. There was a statistically significant increase in image quality between the first and the repeated acquisition