Recombinant Human Myelin Basic Protein Full length protein datasheet (ab43614). Abcam offers quality products including antibodies, assays and other reagents.

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Uncertainty regarding pathogenic mechanisms has been a major impediment to effective prevention and treatment for human neurologic diseases such as multiple sclerosis, tropical spastic paraparesis, and AIDS demyelinating disease. Here, we implicate lymphotoxin (LT) (tumor necrosis factor beta [TNF-beta]) and TNF-alpha in experimental allergic encephalomyelitis (EAE), a murine model of an autoimmune demyelinating disease. In this communication, we report that treatment of recipient mice with an antibody that neutralizes LT and TNF-alpha prevents transfer of clone-mediated EAE. LNC-8, a myelin basic protein-specific T cell line, produces high levels of LT and TNF-alpha after activation by concanavalin A, antibody to the CD-3 epsilon component of the T cell receptor, or myelin basic protein presented in the context of syngeneic spleen cells. LNC-8 cells transfer clinical signs of EAE. When LNC-8 recipient mice were also treated with TN3.19.12, a monoclonal antibody that neutralizes LT and ...

Myelin Basic Protein小鼠单克隆抗体[22](ab11223)可与人样本反应并经IHC实验严格验证，被2篇文献引用。所有产品均提供质保服务，中国75%以上现货。

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Alfa Aesar™ Myelin Basic Protein (1-11), Human 10mg Alfa Aesar™ Myelin Basic Protein (1-11), Human Catalogue Peptides

Previous work has shown that MBP mRNA microinjected into oligodendrocytes is assembled into RNA granules that are transported along the processes and localized to the myelin compartment, while control mRNAs (globin and actin) are assembled into RNA granules that remain in the perikaryon (Ainger et al., 1993). The differential distribution of these mRNAs is presumably controlled by some aspect of their structure. In this study, deletion analysis of MBP RNA was used to identify sequences or structures that are required for transport and/or localization. Digoxigenin-labeled RNAs were synthesized by in vitro transcription and microinjected into cultured oligodendrocytes. Cells were fixed and labeled by immunofluorescence with both anti-digoxigenin antibody to visualize the injected RNA and anti-MBP antibody to visualize the overall cell morphology.. The unique morphology of oligodendrocytes in primary culture makes it possible to spatially resolve three stages in the RNA sorting pathway: (a) granule ...

Direct interaction between transcription factors may provide a mechanism for the regulatory function of these proteins on transcription of the responsive genes. These interactions may be facilitated if the target DNA sequences for the participant regulatory proteins are overlapped or positioned in close proximity to each other within the promoter of the responsive genes. In earlier studies, we identified a cellular protein, named Puralpha, which upon binding to the MB1 regulatory DNA sequence of the myelin basic protein (MBP) gene, stimulates its transcription in central nervous system (CNS) cells. Here, we provide evidence for binding of the ubiquitous DNA binding transcription factor, Sp1, to the MB1 DNA motif at the region that partially overlaps with the Puralpha binding site. We demonstrate that binding of Puralpha to its target sequence is enhanced by inclusion of Sp1 in the binding reaction. Under this condition, binding of Sp1 to the MB1 regulatory sequence remained fairly unchanged, and no

Myelin basic protein (MBP), a major structural protein of myelin, is thought to be important for the maintenance of myelin in the CNS. The synthesis of MBP requires a universal methyl donor, S-adenosylmethionine, whose synthesis is dependent on folate and its involvement in one-carbon metabolism. We hypothesized that maternal folic acid status might affect the synthesis of myelin basic protein (MBP) in the offspring. In order to test this hypothesis, female Sprague-Dawley rats were fed either folic acid sufficient (8mg/kg diet) or deficient diet (0mg/kg diet) from 2 wks prior to the mating throughout the entire pregnancy, lactation and weaning period. The MBP expression was measured by the western blotting analysis and observed by immunohistochemical study. The maternal folic acid deficiency significantly decreased the expression of MBP of spinal cord in offspring at 3, 7 wks of age.( ...

We have studied transport and localization of MBP mRNA in oligodendrocytes in culture by microinjecting labeled mRNA into living cells and analyzing the intracellular distribution of the injected RNA by confocal microscopy. Injected mRNA initially appears dispersed in the perikaryon. Within minutes, the RNA forms granules which, in the case of MBP mRNA, are transported down the processes to the periphery of the cell where the distribution again becomes dispersed. In situ hybridization shows that endogenous MBP mRNA in oligodendrocytes also appears as granules in the perikaryon and processes and dispersed in the peripheral membranes. The granules are not released by extraction with non-ionic detergent, indicating that they are associated with the cytoskeletal matrix. Three dimensional visualization indicates that MBP mRNA granules are often aligned in tracks along microtubules traversing the cytoplasm and processes. Several distinct patterns of granule movement are observed. Granules in the ...

We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and crossed them to RAG-1-deficient mice to obtain mice (T/R-) that have T cells expressing the transgenic TCR but no other lymphocytes. Both T/R+ and T/R- mice carry, in the lymph nodes and spleen, large numbers of …

Chicken polyclonal Myelin Basic Protein antibody validated for WB, ICC/IF and tested in Human, Mouse, Rat and Cow. Immunogen corresponding to synthetic peptide

Peptides , Myelin Oligodendrocyte Glycoprotein (MOG),Myelin Basic Proteins (MBP) , MBP, MAPK Substrate, Biotinylated, Phosphorylated; This is an N-terminally biotinylated peptide, with a phosphorylated Thr97. The sequence APRTPGGRR contains a native sequence derived from bovine myelin basic protein amino acids 95-98 (PRTP). The rest of the sequence is not derived from a native sequence, but is a synthetic construct. APRTPGGRR is specific for MAP kinases: p44MAPK [extracellular signal-regulated kinase 1 (ERK1)] and p42MAPK (ERK2). It contains the consensus sequence Pro-X-(Ser/Thr)-Pro that is recognized by MAP kinase. APRTPGGRR is the most efficient substrate for phosphorylation reaction by ERK and is phosphorylated by kinases on threonine 97 and can also be phosphorylated by MAPK p38.; Biotin-APR-pT-PGGRR; Biotin-Ala-Pro-Arg-pThr-Pro-Gly-Gly-Arg-Arg-OH

The intracellular distribution of various components of the protein translational machinery was visualized in mouse oligodendrocytes in culture using high resolution fluorescence in situ hybridization and immunofluorescence in conjunction with dual channel confocal laser scanning microscopy. Arginyl-tRNA synthetase, elongation factor 1a, ribosomal RNA, and myelin basic protein mRNA were all co-localized in granules in the processes, veins and membrane sheets of the cell. Colocalization was evaluated by dual channel cross correlation analysis to determine the correlation index (% colocalization) and correlation distance (granule radius), and by single granule ratiometric analysis to determine the distribution of the different components in individual granules. Most granules contained synthetase, elongation factor, ribosomal RNA and myelin basic protein mRNA. These results indicate that several different components of the protein synthetic machinery, including aminoacyl-tRNA synthetases, ...

A biotinylated synthetic construct corresponding to amino acids 95-98 (PRTP)of bovine myelin basic protein. APRTPGGRR is a peptide substrate for p44MAPK (ERK1) and p42MAPK (ERK2) kinases.

Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane. MBP was initially sequenced in 1971 after isolation from myelin membranes. Since that time, knockout mice deficient in MBP that showed decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death have been developed. The human gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system. The pool of MBP in the central nervous system is very diverse, with several splice variants being expressed and a large number of post-translational modifications on the protein, which include phosphorylation, ...

An antipeptide antibody was generated in chickens against a sequence shared between the mouse (NP_034907) and human (NP_002376) gene products. Antibodies were affinity-purified and the concentration adjusted to 100 µg/mL.

An antipeptide antibody was generated in chickens against a sequence shared between the mouse (NP_034907) and human (NP_002376) gene products. Antibodies were affinity-purified and the concentration adjusted to 100 µg/mL.

|strong|Mouse anti MBP antibody, clone 2|/strong| recognizes bovine myelin basic protein, also known as 20 kDa microtubule-stabilizing protein. MBP is a 169 amino acid component of the myelin membrane…

We here study the adjuvant properties of immunostimulatory DNA sequences (ISS) and coinjected cytokine-coding cDNA in suppressive vaccination with DNA encoding an autoantigenic peptide, myelin basic protein peptide 68-85, against Lewis rat experimental autoimmune encephalomyelitis (EAE). EAE is an autoaggressive, T1-mediated disease of the CNS. ISS are unmethylated CpG motifs found in bacterial DNA, which can induce production of type 1 cytokines in vertebrates through the innate immune system. Because ISS in the plasmid backbone are necessary for efficient DNA vaccination, we studied the effect of one such ISS, the 5-AACGTT-3 motif, in our system. Treatment with a DNA vaccine encoding myelin basic protein peptide 68-85 and containing three ISS of 5-AACGTT-3 sequence suppressed clinical signs of EAE, while a corresponding DNA vaccine without such ISS had no effect. We further observed reduced proliferative T cell responses in rats treated with the ISS-containing DNA vaccine, compared with ...

Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican-gene expression and morphogenesis is disrupted. We have designed a whole-animal screen that tests for rescue of both up- and down-regulated gene expression in mutant embryos, together with analysis of weak and strong alleles. From a screen of 3120 structurally diverse compounds, we have identified 68 that reduce versican-b expression in the adgrg6 mutant ear, 41 of which also restore myelin basic protein gene expression in Schwann cells of mutant embryos. Nineteen compounds unable to rescue a strong adgrg6 allele provide candidates for molecules that may interact directly with the Adgrg6 receptor. Our pipeline provides a powerful approach for identifying compounds that modulate GPCR activity, with potential impact for future drug ...

The effect of immunization with neural and nonneural antigens on hypothalamic and mesencephalic neurotransmission and antibody response have been investigated. Treatment of SJL/N mice with bovine myelin basic protein (BMBP), mouse spinal cord homogenate (MSCH) or bovine serum albumin (BSA) produced no significant changes in the average hypothalamic and mesencephalic noradrenaline (NA) or serotonin (5-HT) content. In Balb/c mice, however, treatment with BMBP caused a significant increase in mesencephalic NA, and treatment with MSCH caused a significant increase in hypothalamic 5-HT 3 weeks after the first antigenic challenge. The SJL/N strain showed a high antibody response to BMBP and BSA, and a moderate one to MSCH, while in Balb/c mice, there was a low response to BMBP, a moderate one to MSCH and a high response to BSA. Significant, positive correlations were found between the level of antigen-specific serum antibodies and the following neurotransmitters: hypothalamic NA in the BMBP and ...

Gandelman, K.Y., S.E. Pfeiffer, and J.H. Carson. Cyclic AMP regulation of P0 glycoprotein and myelin basic protein gene expression in semi-differentiated peripheral neurinoma cell line D6P2T. Development 106.2 (1989): 389-398. Web. 05 April. 2020. ...

PepTivator® MBP Isoform 1 is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of human myelin basic protein (MBP) isoform 1 (UniProt ID: P02686-1).In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. - Ireland

Boggs, J.M., Myelin Basic Protein: A Multifunctional Protein. Cell. Mol. Life Sci. 63 (2006) 1945-61. Boggs, J. M., Rangaraj, G., Gao, W., and Heng, Y-M., Effect of phosphorylation of myelin basic protein by MAPK on its interactions with actin and actin binding to a lipid membrane in vitro, Biochemistry 45 (2006) 391-401 Musse, A. A., Boggs, J. M., and Harauz, G., Deimination of membrane-associated myelin basic protein in multiple sclerosis exposes an immunodominant epitope, Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 4422-4427 co-SRA . Comment by C. Husted, Structural insight into the role of myelin basic protein in multiple sclerosis, pp. 4339-4340.. Boggs, J. M., Gao, W., and Hirahara Y., Myelin glycosphingolipids, galactosylceramide and sulfatide, participate in carbohydrate-carbohydrate interactions between apposed membranes and may form glycosynapses between oligodendrocyte and/or myelin membranes. Biochim. Biophys. Acta 1780 (2008) 445-455 . Polverini, E., Rangaraj, G., Libich, D., Boggs, ...

Myelin basic proteins (MBP) can be an important element of the myelin sheath surrounding neurons which is directly affected in demyelinating illnesses. bovine MBP consist of N-terminal acetylation in elements C1, C2, and C3; Oxidation of methionine 19 in every five elements; All charge isomers acquired both a mono- and di-methylated (symmetric) arginine at placement 106; Deimination in arginines 23 9041-93-4 IC50 and 47 was discovered only in element C8b; Deimination of arginine 96 and deamidation in glutamine 102 was within elements C2, C3, C8a, and C8b; Phosphorylation in threonine 97 was limited to charge elements C2 and C3; Deimination in arginine 161 was just found in element C3; Deamidation of glutamine 120 was just seen in C1. All deiminated arginines and one acetylated lysine were initial revealed within this research for bovine MBP experimentally. Mascot database looking combined with series evaluation of rattlesnake MBP supplied 9041-93-4 IC50 a lot more than 85% series coverage. ...

Myelin basic protein (MBP) comprises about 20% of the myelin sheath in neuronal axons. MBP is commonly used to induce autoimmune encephalomyelitis in animal models.

Advances in our understanding of the structure and molecular biology of the T lymphocyte antigen-receptor have now made it feasible to study human autoimmune diseases using new approaches. One such approach involves cloning of T cells from sites of autoimmune pathology followed by identification of putative disease-related T cell oligoclonality at the level of the T cell receptor gene rearrangements. We have now tested the feasibility of this approach in an animal model of autoimmunity, murine experimental allergic encephalomyelitis (EAE). Spinal cord-derived, self (murine) myelin basic protein (MBP)-reactive T cell lines and sublines were analyzed at the level of their receptor beta chain rearrangements using Southern blots. We now report that the MBP-reactive T cell lines and sublines derived from the spinal cords of four of five SJL/J mice with EAE share a 14.5-kb rearranged T cell receptor beta 1 band on Southern blots. A spinal cord-derived T cell line that was reactive to purified protein ...

Matrix Metalloproteinase Proteolysis of the Myelin Basic Protein Isoforms Is a Source of Immunogenic Peptides in Autoimmune Multiple Sclerosis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Most brain gene expression studies of schizophrenia have been conducted in the frontal cortex or hippocampus. The extent to which alterations occur in other cortical regions is not well established. We investigated primary visual cortex (Brodmann area 17) from the Stanley Neuropathology Consortium collection of tissue from 60 subjects with schizophrenia, bipolar disorder, major depression, or controls. We first carried out a preliminary array screen of pooled RNA, and then used RT-PCR to quantify five mRNAs which the array identified as differentially expressed in schizophrenia (myelin basic protein [MBP], myelin-oligodendrocyte glycoprotein [MOG], β-actin [ACTB], thymosin β-10 [TB10], and superior cervical ganglion-10 [SCG10]). Reduced mRNA levels were confirmed by RT-PCR for MBP, ACTB and TB10. The MBP reduction was limited to transcripts containing exon 2. ACTB and TB10 mRNAs were also decreased in bipolar disorder. None of the transcripts were altered in subjects with major depression. Reduced MBP

Rat MBP/Myelin Basic Protein cDNA ORF clone in cloning vector (pGEM-T Vector) (RG81319-G) is confirmed by full-length sequence verification for gene expression studies or other applications. Quote for bulk production.

Mbp - Mbp (Myc-DDK-tagged) - Mouse myelin basic protein (Mbp), transcript variant 8 available for purchase from OriGene - Your Gene Company.

The purpose of this study was to test the concept of a tolerogenic vaccine. The prediction was that a fusion protein containing a tolerogenic cytokine and the major encephalitogenic determinant of GPMBP (i.e., the NAg) would represent a qualitatively superior tolerogen compared with Ag alone. The covalently linked cytokine was predicted to provide two critical activities. First, the cytokine was predicted to bind the respective receptors on particular subsets of APC and condition those APC to express tolerogenic, anti-inflammatory, or inhibitory activity. Secondly, the binding of the cytokine domain to the cytokine receptor on those APC was predicted to target the covalently tethered Ag to the MHCII Ag processing pathway of those APC. Such a mechanism would ensure presentation of the covalently tethered NAg predominantly on cytokine-conditioned APC. Six cytokines were tested as potential candidates, including IL1-RA, IL-2, IL-4, IL-10, IL-13, and IL-16. IL-1RA and IL-16 were predicted to have ...

Therapies that Ag-specifically target pathologic T lymphocytes responsible for multiple sclerosis (MS) and other autoimmune diseases would be expected to have improved therapeutic indices compared with Ag-nonspecific therapies. We have developed a cellular immunotherapy that uses chimeric receptors to selectively redirect therapeutic T cells against myelin basic protein (MBP)-specific T lymphocytes implicated in MS. We generated two heterodimeric receptors that genetically link the human MBP84-102 epitope to HLA-DR2 and either incorporate or lack a TCRzeta signaling domain. The Ag-MHC domain serves as a bait, binding the TCR of MBP-specific target cells. The zeta signaling region stimulates the therapeutic cell after cognate T cell engagement. Both receptors were well expressed on primary T cells or T hybridomas using a tricistronic (alpha, beta, green fluorescent protein) retroviral expression system. MBP-DR2-zeta-, but not MBP-DR2, modified CTL were specifically stimulated by cognate MBP-specific T

Wuhan, China. 430074, 18th May 2017. Anti-MBP Tag Mouse Monoclonal Antibody (9Y5) is the new addition to the illustrious list of antibodies made by popular scientific research outfit, Abbkine Scientific. The company recently announced the launch of the product, made to enhance scientific research and experiments.. MBP is a member of the maltose E.coli family that is responsible for the uptake and efficient catabolism of maltodextrins. The features and benefits of the substance have made it endearing to scientific researchers.. Otherwise known as Maltose Binding Protein antibody, the antibody is designed to help promote proper folding of the fusion protein, in addition to being used for preventing an insoluble form. Mouse, with recombinant protein as the immunogen, hosts the antibody. This is in addition to being a useful affinity tag for increasing the expression level, and solubility of the MBP-tagged protein.. MBP Tag antibody as it is also called is purified using the latest technology. It is ...

Highlights: •SVIP (small p97/VCP-interacting protein) co-localizes with myelin basic protein (MBP) in compact myelin. •We determined that SVIP is an intrinsically disordered protein (IDP). •The helical content of SVIP increases dramatically during its interaction with negatively charged lipid membrane. •This study provides structural insight into interactions between SVIP and myelin membranes. -- Abstract: SVIP (small p97/VCP-interacting protein) was initially identified as one of many cofactors regulating the valosin containing protein (VCP), an AAA+ ATPase involved in endoplasmic-reticulum-associated protein degradation (ERAD). Our previous study showed that SVIP is expressed exclusively in the nervous system. In the present study, SVIP and VCP were seen to be co-localized in neuronal cell bodies. Interestingly, we also observed that SVIP co-localizes with myelin basic protein (MBP) in compact myelin, where VCP was absent. Furthermore, using nuclear magnetic resonance (NMR) and ...

CD56 is a member of the neural cell adhesion molecule family expressed on cells of the central nervous system and also on NK cells. Previous studies suggest the involvement of CD56 in effector-to-target cell conjugation mediated by NK cells. It was shown recently that CD56 is also expressed by subpopulations of CD8+ and CD4+ T cells. The present study describes the functional characteristics of CD4+CD56+ T cell lines established from blood of multiple sclerosis patients by stimulation with myelin basic protein (MBP). CD4+CD56+, MBP-specific T cell lines were able to lyse MBP-pulsed target cells in an HLA class II-restricted fashion. At the same time, they mediated MHC-unrestricted lysis of CD56+ target cells such as CD56+ lymphoid or glial tumor cells, but not of the typical NK target, K562. A number of experimental results including separation of CD4+CD56+ T cells into CD56 high and low expressing populations, cold target inhibition, as well as killing of CD56-transfected cells indicate that ...

Transplantation of neural precursor cells has been proposed as a possible approach for replacing missing or damaged central nervous system myelin. Neonatal and adult myelin-deficient shiverer (shi) mice, bearing a mutation of the myelin basic protein (MBP) gene, have been used extensively as hosts for testing cell engraftment, migration, and myelination, but relatively little progress has been made in reversing shi motor deficits. Here we describe a prenatal cell replacement strategy, showing that embryonic stem cells injected into shi blastocyst embryos can generate chimeric mice with strong and widespread immunoreactive MBP expression throughout the brain and a behavioral (motor) phenotype that appears essentially rescued.

Multiple sclerosis (MS) was initially described in the nineteenth century in Europe and subsequently in North America. The diary and letters of Sir Augustus Frederick dEste (1794-1848), the grandson...

1FV1: Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.

For many of our patients with CIDP, blood was collected when they were hospitalised for treatment of active disease exacerbation. A difference in cytokine profiles between the exacerbation and remission stages of CIDP has been reported.58 Our finding of increased numbers of spontaneous Th1 IFN- and Th2 IL-5 secreting cells in patients with CIDP is partly at odds with a previous report of increased proportions of only Th2-IL-4 secreting CD4+T cells in the peripheral blood of 12 patients with CIDP.51 We found increased numbers of spontaneous, but not antigen specific, IL-5 secreting PBMC in patients with CIDP compared with healthy controls and patients with ON. Others have found increased levels of both the Th1 (IFN-) and Th2 (IL-4) cytokines in the exacerbation stage of CIDP, but an elevation of only IL-4 secreting Th2 cells in remission.58 It is important to note that our ELISPOT methodology detected IL-5 rather than IL-4 as a measure of Th2 cytokine secretion. CIDP patient cells tested in ...

A cytosolic insulin-sensitive serine kinase has been purified to apparent homogeneity in parallel from livers of control or acutely insulin-treated rats. The kinase is labile and requires rapid purification for stability. The kinase migrates as a band of apparent Mr = 90,000 on denaturing gels and elutes as a monomer on Superose 12 gel filtration. After sodium dodecyl sulfate-polyacrylamide gel electrophoresis and renaturation, the 90-kDa band presumed to be the kinase shows kinase activity toward myelin basic protein in situ. Substrates of the kinase include Leu-Arg-Arg-Ala-Ser-Leu-Gly (Kemptide), ribosomal protein S6, S6 peptide, a proline-rich peptide substrate, microtubule-associated protein 2, and myelin basic protein. The kinase also phosphorylates histones H1 and H2B, but does not autophosphorylate to a significant stoichiometry. The activity of the kinase is inhibited by fluoride, glycerophosphate, p-nitrophenyl phosphate, p-nitrophenol, heparin, quercetin, poly-L-lysine, and potassium phosphate

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Reaktivität: Huhn, Rind (Kuh), Hund and more. 62 verschiedene MBP ELISA Kits vergleichen. Alle direkt auf antikoerper-online.de bestellbar!

Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4+ T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells most efficiently is the dendritic cell (DC). As such, we should be able to trigger EAE by transfer of DC that can present the relevant autoantigen(s). Despite some sporadic reports, however, models of DC-driven EAE have not been widely adopted. We sought to test the feasibility of this approach and whether activation of the DC by toll-like receptor (TLR)-4 ligation was a sufficient stimulus to drive EAE. Host mice were seeded with myelin basic protein (MBP)-reactive CD4+ T cells and then were injected with DC that could present the relevant MBP peptide which had been exposed to lipopolysaccharide as a TLR-4 agonist. We found that this approach induced robust clinical signs of EAE. DC are sufficient as APC to effectively drive the differentiation of naïve myelin-responsive T cells

MBP-1 acts as a general transcriptional repressor. Overexpression of MBP Antibody induces cell death in the numbers of certain cancer cells and tumor growth returning from Los Angeles. But the role of endogenous MBP-1 in normal cell growth regulation is … Continue reading →. ...

Sphingolin is a scientifically designed supplement containing a specially prepared source of bovine myelin sheath, a rich source of naturally occurring myelin basic protein.

How is Uteroferrin Associated Basic Protein abbreviated? UABP stands for Uteroferrin Associated Basic Protein. UABP is defined as Uteroferrin Associated Basic Protein rarely.

1K2D: Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au

Mechanistically, the authors showed again that peripheral CD4+CD25+Foxp3+ Tregs mediated tolerance, while the results of experiments in T cell receptor transgenic animals showed no evidence for clonal deletion of MBP-reactive effector T cells, despite some level of expression in the thymus of liver MBP-transgenic mice (20). Importantly, expression of MBP in the skin did not protect against EAE, which indicates that expression of this protein in the hepatic environment is critical. In an elegant set of experiments based on adoptive transfer of Tregs and effector T cells labeled with fluorescent dye, the authors showed that Tregs induced by hepatic expression can turn effector T cells into Tregs by inducing expression of the transcription factor Foxp3. Effector T cells lacking TGF-β receptor II were resistant to this infectious tolerance mechanism, indicating dependence on TGF-β signaling. These findings are reminiscent of TGF-β-dependent suppression of CD8+ T cells by CD4+CD25+Foxp3+ Tregs ...