Define mycetoma. mycetoma synonyms, mycetoma pronunciation, mycetoma translation, English dictionary definition of mycetoma. n. pl. my·ce·to·mas or my·ce·to·ma·ta A chronic, slowly progressing bacterial or fungal infection usually of the foot or leg, characterized by nodules that...
Ventricular tachycardia can be caused by different structural abnormalities of the heart tissue, frequently related to fibrotic scars from ischemic and nonischemic origin. Cardiac tumors, particularly in pediatric patients, are also associated with clinically significant arrhythmias.1 In adults, non-Hodgkin lymphoma has been reported as a cause for ventricular arrhythmias. In this report, we describe a tumorlike cardiac fungal mycetoma caused by S apiospermum presenting as ventricular tachycardia associated with hemodynamic instability. Mycetoma is primarily a granulomatous disease of the skin and subcutaneous tissue, caused by fungi (eumycetoma) or aerobic bacteria (actinomycetoma) that occasionally involve other tissues, particularly in immunocompromised patients.2 S apiospermum endocarditis has been previously described in a patient after cardiac surgery.3 Floating atrial mycetomas caused by S apiospermum infection have been recently reported in a patient with cystic fibrosis who underwent ...
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Eumycetoma is a chronic cutaneous and subcutaneous infection caused by various genera of fungi. Approximately 40% of mycetomas worldwide are eumycotic as opposed to actinomycotic (ie, caused by bacterial actinomycetes).
1) Mycetoma containing fungi. (2) Eumycetoma is the fungal form of Mycetoma. Mycetoma is a disease of the skin and of connective tissue. See also: Mycetoma Skin Glossary ...
Mycetoma (Madura foot): A case report. Asly M, Rafaoui A, Bouyermane H, Hakam K, Moustamsik B, Lmidmani F, Rafai M, Largab A, Elfatimi A. Ann Phys...
To the Editor.-A recent study documents the efficacy of dapsone in the treatment of Nocardia asteroides mycetoma.1 Reference was made to successful treatment of
Mycetoma is a devastating, chronic infectious disease of the skin and subcutaneous tissue that can be either bacterial in origin (actinomycetoma) or fungal (eu
Mycetoma is a fungal infection; when it affects the foot it is called madura foot. The pathogen is from the nocardia species, which can cause septicemia.
We report the case of a 30-year-old Nigerian patient with mycetoma of the foot without bone involvement caused by Fusarium sp..Long-term administration of ketoconazole produced a significant improvement with good clinical and biological tolerance.
Mycetoma answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Madura foot symptoms, causes, diagnosis, and treatment information for Madura foot (Mycetoma) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
Coloured scanning electron micrograph (SEM) of Curvularia verruculosa - vegetative, septate, dematiaceous hyphae. Curvularia verruculosa is a filamentous hyphomycete fungus. It is a common mould that is a soil facultative pathogen of many plant species, especially in tropical regions. It can cause Curvularia leaf spot and also food spoilage in pineapple fruits. Curvularia verruculosa can also cause eumycotic mycetomas in animals. Curvularia species can be the causative agents of phaeohyphomycosis. In humans Curvularia can cause wound infection, mycetoma, onychomycosis, keratitis, allergic sinusitis, cerebral abscess, cerebritis, pneumonia, allergic bronchopulmonary disease, endocarditis, and peritonitis. Magnification: x320 when shortest axis printed at 25 millimetres. - Stock Image C032/3185
A 47-year-old female of African origin, presented with history of a growing lump on the sole of her right foot. She normally lives in the UK, but has been visiting an Afr..
TY - JOUR. T1 - Phycomycosis. T2 - A cause of bronchial obstruction. AU - Donohue, J. F.. AU - Scott, R. J.. AU - Walker, David. AU - Bromberg, P. A.. PY - 1980. Y1 - 1980. N2 - A patient with diabetes mellitus presented with an obstructing mycetoma in the right bronchus intermedius due to Phycomycetes. Review of the literature revealed eight prior case reports of patients with prominent endobronchial disease attributable to phycomycosis. Indolent, obstructing lesions in large bronchi were noted in diabetics. The clinical illness differed from the fulminant fungal pneumonia noted in leukemics but was also lethal because of localized complications such as erosion into the pulmonary artery. The differential diagnosis included mucoid impaction, bronchocentric granulomatosis, and mycotic bronchitis. Surgical resection appears to be the appropriate therapy for well localized bronchial lesions.. AB - A patient with diabetes mellitus presented with an obstructing mycetoma in the right bronchus ...
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A list of words that start with My in the enable censored word list. my myalgia myalgias myalgic myases myasis myasthenia myasthenias myasthenic myasthenics mycele myceles mycelia mycelial mycelian mycelium myceloid mycetoma mycetomas mycetomata etc.
Title: Evaluation of the Combined Therapy of DA-7218, a New Oxazolidinone, and Trimethoprim/ Sulfamethoxazole in the Treatment of Experimental Actinomycetoma by Nocardia brasiliensis. VOLUME: 7 ISSUE: 3. Author(s):N.A. Espinoza-Gonzalez, O. Welsh, J. Ocampo-Candiani, S. Said-Fernandez, G. Lozano-Garza, S.H. Choi and L. Vera-Cabrera. Affiliation:Servicio de Dermatologia, Hospital Universitario Dr. Jose E. Gonzalez, Ave. Francisco I. Madero y Ave. Dr. Jose Eleuterio Gonzalez S/N, Colonia Mitras Centro, Monterrey, N.L. 64460 Mexico.. Keywords:Actinomycetoma, oxazolidinones, torezolid, DA-7157, DA-7218. Abstract: Objectives: Currently, for actinomycetoma, combined antimicrobial therapy is preferred to the use of a single compound. This is in order to provide a broader-spectrum coverage due to a combinatory or synergistic effect between the drugs, and to decrease the possibility of emergence of natural resistant strains. A new oxazolidinone pro-drug, DA-7218 ...
The outer layer of the skin. The epidermis is also the thinnest layer, responsible for protecting you from the harsh environment. The epidermis is made up of five layers of its own: stratum germinativum, stratum spinosum, stratum granulosum, stratum lucidum and stratum corneum. See also: * Basal Cell Layer * Squamous Cell Layer * Skin Conditions * Skin Care * Skin Functions * Lymphedema Skin Infections * Lymphedema Fungal Infections * Dermatofibromas * Impetigo * Mycetoma Fungal Infection * Skin Care, conditions, complications * Skin Glossary ...
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Mycetoma is a neglected chronic and granulomatous infection primarily associated with the fungal pathogen Madurella mycetomatis. Characteristic of this infection is the formation of grains. However, the processes leading to grain formation are not known. In this study, we employed a proteomic approach to characterise M. mycetomatis grain formation in Galleria mellonella larvae and map the processes leading to grain formation over time. For this, at 1 day, 3 days and 7 days post-inoculation, proteins from grains and hemolymph were extracted and analysed by label-free mass spectrometry. A total of 87, 51 and 48 M. mycetomatis proteins and 713, 997, 18 G. mellonella proteins were found in grains on day 1, 3 and 7 post-inoculation respectively. M. mycetomatis proteins were mainly involved in cellular metabolic processes and numerous enzymes were encountered. G. mellonella proteins were primarily involved in the nodulation process. The proteins identified were linked to nodulation and grain formation ...
GELABERT-GONZALEZ, M. et al. Scedosporium apiospermum brain abscess: Report of one case with literature review. Neurocirugía [online]. 2010, vol.21, n.2, pp.125-131. ISSN 1130-1473.. Scedosporium apiospermum is a fungus found in the soil and in contaminated water and commonly cause cutaneous infections and is a rare cause of central nervous system infection. Invasive infection is usually associated with immunosuppresion. The authors present a 73-year-old woman with chronic renal disease who presented with headache for 2 weeks. Computerized tomography scans revealed a ring-enhancing lesion in left temporal lobe. An urgent craniotomy was performed and the lesion was totally removed. The patient died 5 days later. Scedosporium apiospermum was isolated in the culture of the extirpated lesion. The authors review the previously reported cases of brain abscess for Scedosporium apiospermum.. Palabras clave : Brain abscess; Pseudallescheria boydii; Scedosporium apiospermum; Voriconazole. ...
Author summary Eumycetoma is a neglected fungal disease endemic in Africa, India, and Latin America. Black-grain eumycetoma is the most common type in Africa and is mainly caused by Madurella spp. The Sudan, and in particular Gezira State, central Sudan is hyperendemic for black-grain eumycetoma. Patients with this type of mycetoma are treated with surgery in combination with antifungal therapy. In this study, we collected surgical biopsies from patients attending Gezira Mycetoma Center to directly identify the etiology of black-grain eumycetoma in this state. We also studied the epidemiology of the disease based on the demography of the patients population. Our result showed that the highest endemic regions were Southern Gezira (76.6%) and Northern Sinnar (23.4%). By applying direct PCR and sequencing we confirmed that the most common etiology of the disease is Madurella mycetomatis (88.2%). In addition, we found one case of M. fahalii and the first Sudanese case of M. tropicana and Sphaerulina
Scedosporium apiospermum and S. prolificans are fungi of increasing clinical importance, particularly in persons with underlying diseases. We reviewed the records of 59 patients in Australia from whom Scedosporium spp. were isolated from June 30, 1997, through December 31, 2003. S. apiospermum was isolated predominantly from the respiratory tracts of 28 of 31 patients with underlying lung diseases and resulted in 2 infections and 1 death. The annual number of S. apiospermum isolates remained constant. S. prolificans was isolated from 28 patients only after November 1999. Eight patients with acute myeloid leukemia or hematopoietic stem cell transplants had invasive infection; 4 had fungemia and 6 died from infection. S. prolificans caused locally invasive infection in 2 immunocompetent patients and was found in the respiratory tract of 18 patients with underlying respiratory disease but did not cause fungemia or deaths in these patients. Scedosporium spp. showed distinct clinical and epidemiologic
As for Scedosporium prolificans, all combinations were indifferent but synergy was detected for 15 to 25% of isolates for some combinations. The most active combination was ravuconazole plus caspofungin, which was synergistic against 41.7% of S. prolificans isolates when MEC values were used as endpoints.. Notably, antagonism was absent for all antifungal combinations against both Scedosporium spp.. The combined activity of antifungal agents against Scedosporium has rarely been evaluated previously. A report on the combined effect in vitro of amphotericin B and azole agents (miconazole, itraconazole, and fluconazole) against S. apiospermum was published in 1995 (26). Authors used the checkerboard technique and described an average indifferent effect, but synergy was found for some isolates, particularly for the amphotericin B and miconazole combination. Antagonism was not reported.. Meletiadis et al. reported that the combination of terbinafine with miconazole, voriconazole, or itraconazole ...
CASE REPORT. Mycetoma by Nocardia asteroides: a 9 year folow-up. Micetoma por Nocardia asteroides: acompanhamento de 9 anos. Giani de Oliveira SaraçaI; Loan TowerseyII; Roderick James HayIII; Alberto Thomaz LonderoIV; Eunice de Castro Soares MartinsV; Alberto Torres AmoraVI; Kátia Maria Pereira Nunes ReisVII; Ana Maria Nunes MendonçaVIII; Rogerio Ribeiro EstrellaIX. IAdjunct Professor of Mycology, Instituto Biomédico, Universidade Federal Fluminense, Post Graduation student, Dermatology Division, HUAP, Universidade Federal Fluminense, RJ. Brazil ...
Sharma, Sanjeev Kumar ; Mukherjee, Anjan ; Singh, Avinash Kumar ; Seth, Tuika ; Kumar, Suman ; Mishra, Pravas ; Xess, Immaculata ; Gupta, Somesh ; Mahapatra, Manoranjan ; Pati, ...
Introducción. En los últimos años se observa un aumento de la prevalencia de colonización e infección por Scedosporium spp. en pacientes con fibrosis quística (FQ). En el presente estudio se registra la frecuencia de aislamiento de Scedosporium spp. en una Unidad de FQ de adultos, analizándose las características de los pacientes y los factores predisponentes.. Métodos. Se realizó un estudio observacional retrospectivo en 87 pacientes adultos con FQ en los que se valoró la presencia de cultivo positivo para Scedosporium spp. durante 5 años (enero de 2012-julio de 2017). Se recogieron las siguientes variables clínicas: edad, sexo, índice de masa corporal, genotipo, presencia de insuficiencia pancreática, colonizaciones bacterianas, función pulmonar, complicaciones, exacerbaciones y tratamiento, así como puntuación Bhalla modificada de la última tomografía computarizada axial de alta resolución. Los resultados se analizaron con el paquete estadístico IBM SPSS Statistics ...
Background: This is a retrospective, analytic observational study where we describe cases of sporotrichosis and mycetoma from Acapulco General Hospital and Community Dermatology Mexico C.A. over 25 years. Analysis of environmental features that favour the development of such diseases has been made, as well as the limitations in the study and treatment of such diseases in resource poor settings. Methods: We reviewed the information on 76 sporotrichosis and 113 mycetoma patients out of a total of 14,000 consultations at Acapulco General Hospital and from Community Dermatology clinics. We analysed the epidemiological and mycological characteristics and the investigations used for diagnosis such as direct examination, culture, intradermal test reactions, and biopsy. Results: In total 91 confirmed cases of actinomycetoma, 22 of eumycetoma and 76 of sporotrichosis have been identified including diagnostic studies for both diseases and their treatment. Discussion: The results obtained have been analysed and
We describe an 8-year-old girl who sustained multiple compound fractures in an accident involving agricultural equipment. She developed Scedosporium prolificans osteomyelitis of the pelvis, septic arthritis of the hip, and myositis of adjacent muscles. The infection progressed, despite extensive surgical debridement and joint washouts with 0.2% polyhexamethylene biguanide; antifungal therapy with caspofungin, terbinafine, and voriconazole; and adjunctive therapy with interferon-α. Gradual resolution was achieved after the addition of a novel agent, hexadecylphospocholine (miltefosine), and the continuation of terbinafine and voriconazole. This is the first report of the use of miltefosine as an antifungal agent in the management of severe infection with S. prolificans.. ...
Abstract A case of mycetoma of the mandible caused by Madurella mycetomii is reported. Diagnosis was established by culture, histopathology and serology.
Coloured scanning electron micrograph (SEM) of Acremonium stromaticum, a hyaline hyphomycete (glassy, lightly pigmented conidial fungus) that occurs widely in nature but is also encountered as a contaminant. Asexual reproduction is by conidiophores that produce conidia (phialoconidia or ameroconidia) at hyphal branches. A. stromaticum is one of the causative agents of eumycotic white grain mycetoma. It is also one of five fungi present in most banana root and rhizome lesions in many parts of the tropics. A. stromaticum is known to cause opportunistic infections (hyalohyphomycosis) in immunocompromised patients, including arthritis, osteoarthritis, peritonitis, endocarditis, pneumonia, cerebritis and subcutaneous infection. Magnification: x1,200 when shortest axis printed at 25 millimetres. - Stock Image C032/2959
TO THE EDITOR: Streptomyces spp. are aerobic, gram-positive bacteria of the order Actinomycetales, known for their ability to produce antimicrobial molecules such as streptomycin. Streptomyces spp., usually saprophytic to humans, can cause local cutaneous fistulized nodules known as actinomycetoma or mycetoma. Severe invasive infections have seldom been reported, but most cases reported have occurred in immunocompromised patients (1-5). We report a case of invasive pulmonary infection caused by a Streptomyces sp. in a splenectomized patient with sarcoidosis ...
FIG. 5. One of the 2,496 most-parsimonious trees obtained from heuristic searches based on analysis produced from the combined data set. Bootstrap support values of 100% are indicated at the nodes. Type strains are indicated with boldface type. P. africana and S. prolificans were used as outgroups. Pb, P. boydii; Pe, P. ellipsoidea; Pf, P. fusoidea; Pa, P. angusta; Pm, P. minutispora; Sa, S. aurantiacum; Paf, P. africana; Sp, S. prolificans; S, source; T, teleomorph; G, Graphium anamorph; CI, consistency index; RI, retention index; HI, homoplasy index; c, clinical; e, environmental; +, presence; −, absence. ...
Results There were 4 children (all girls), median age 15 years (range 10-16), with a median FEV1% predicted of 70.5% (range 55-88%). 2 children chronically isolated L.prolificans, 2 isolated S.apiospermum. 3 also had CF related diabetes and chronic Pseudomonas aeruginosa infection. 1 child received treatment for 6 weeks. 3 children are taking long- term treatment (median 50 weeks; range 35-59). 2 children improved FEV1% predicted with treatment by 14% and 15%; one was stable. Importantly the trend graphs for lung function in these 3 children appear to stabilise post initiation of treatment. One child did not improve her lung function but also had recurrent MRSA infections and significant nutritional complications. No adverse effects from the combination were reported. Posaconazole levels were therapeutic (,1 mg/l) in all children (range 1.22-3.85 mg/l). Terbinafine levels were not measured. ...
Dr. Andrew Balfouer, a Scottish physician and the first director of the Wellcome Tropical Research Laboratory in Khartoum (1903-1913) was the first to report on a case of mycetoma in the Sudan in 1904. Dr. Balfour noted that the disease was common amongst Northern Sudanese, that the foot was affected most and that the commonest type was the black grain variety.. The first case from Southern Sudan was reported in 1908 from Borr, in the Upper Nile Province by Dr. Chris Morley Wenyon, the eminent London microbiologist when he was the Travelling Pathologist of the Sudan government.. Extensive studies of two causal organisms were carried out by Dr. Albert Chalmers, Director of the Wellcome Tropical Research Laboratories (1913-1920), together with Captain R.G. Archibald, pathologist, and Dr. J.B. Christopherson, Director of Khartoum and Omdurman Civil Hospitals.They carried out valuable systemic mycological and pathological studies of the causal organisms. Chalmers and Archibald gave quite an ...
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Effective control can be achieved when selected public health approaches are combined and delivered locally. Interventions are guided by the local epidemiology and the availability of appropriate measures to detect, prevent and control diseases. Implementation of appropriate measures with high coverage will contribute to achieving the targets of the WHO NTD Roadmap on neglected tropical diseases, resulting in the elimination of many and the eradication of at least two by 2020.. In May 2013, the 66th World Health Assembly resolved to intensify and integrate measures against neglected tropical diseases and to plan investments to improve the health and social well-being of affected populations. WHO is working with Member States to ensure the implementation of resolution WHA66.12.. In 2016, the 69th Assembly adopted resolution WHA69.21 on addressing the burden of mycetoma and requested WHO, through the Strategic and Technical Advisory for Neglected Tropical Diseases, to define a systematic, ...
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Erstellt am18. Mai 2020 Dear valued colleagues, A new video is now available on our YouTube Channel Infectious Diseases in Motion. Our research physician Jannik Stemler presents prognostic factors and treatment strategies of invasive infections with Scedosporium spp. and Lomentospora prolificans, emerging pathogens associated with high mortality rates. Video: https://www.youtube.com/watch?v=PAe9_CKtLxQ Publication: https://bit.ly/2zxywgM We hope you enjoy watching! With best […]. Weiterlesen ...
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