Hypertension (HTN) and diabetes (DM) are comorbid conditions, each associated with inflammation. Lipopolysaccharide (LPS) is elevated in the serum of patients with DM and capable of robustly activating the immune system. Risk of erectile dysfunction (ED) is increased in both HTN and DM. Vascular relaxation is needed to regulate vascular tone and erectile function. Our previous studies showed that corpus cavernosum (CC) nitrergic relaxation to electrical field stimulation (EFS) was reduced after LPS exposure. It is not known whether LPS-induced inflammation plays a role in DM-associated ED. Our study aim was to examine vascular function of rat CC under high glucose conditions in the presence of LPS. We hypothesized that high glucose would exacerbate the LPS-induced decrease in EFS relaxation. Isolated rat CC strips incubated with control (5mM) or high glucose (HG, 25 mM) media with or without LPS (1 ug/mL) for 6 h. CC strips were mounted in a myograph and pre-contracted with phenylephrine (PE, ...
Muscle Relaxation is helps to move freely. Muscles are important to produce force and motion. Stay fit with healthy muscles. Read all solutions for Muscle Relaxation.
Force relaxation and permanent deformation processes in erythrocyte membrane were investigated with two techniques: micropipette aspiration of a portion of a flaccid cell, and extension of a whole cell between two micropipettes. In both experiments, at surface extension ratios ,3:1, the extent of residual membrane deformation is negligible when the time of extension is less than several minutes. However, extensions maintained longer result in significant force relaxation and permanent deformation. The magnitude of the permanent deformation is proportional to the total time period of extension and the level of the applied force. Based on these observations, a nonlinear constitutive relation for surface deformation is postulated that serially couples a hyperelastic membrane component to a linear viscous process. In contrast with the viscous dissipation of energy as heat that occurs in rapid extension of a viscoelastic solid, or in plastic flow of a material above yield, the viscous process in this ...
One mechanism that could account for impairment of eNOS-mediated relaxation is decreased availability of NO to produce relaxation, due to scavenging of NO by O2−. Conditions that produce elevated O2− in blood vessels are associated with impaired eNOS-dependent relaxation (21,24,26, 37). For example, impaired endothelium-dependent relaxation in inflammation, atherosclerosis, and diabetes is improved by SOD (5,21,26). In the present study, restoration of endothelium-dependent relaxation by PEG-SOD provides strong evidence that the impairment during diabetes is mediated by O2− in arteries from IL-10−/− mice.. In addition to using PEG-SOD in studies of vasomotor function, we examined relative levels of O2− in the vessel wall using confocal microscopy and hydroethidine. We used this method previously to detect O2− in blood vessels (5,9,26). Findings with hydroethidine staining were consistent with effects of PEG-SOD on function and suggest that O2− levels are higher in blood vessels ...
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Nitric oxide (NO) is a highly reactive molecule that rapidly diffuses and permeates cell membranes. In animals, NO is implicated in a number of diverse physiological processes, such as neurotransmission, vascular smooth muscle relaxation, and platelet inhibition. It may have beneficial effects, e.g., as a messenger in immune responses, but it is also potentially toxic when the antioxidant system is overwhelmed and reactive oxygen intermediates (ROI) accumulate. During the last few years, NO has been detected in several plant species, and an increasing number of reports on its function have implicated NO as an important effector in plant growth, development, and defense. The broad chemistry of NO involves an array of interrelated redox forms with different chemical reactivities and numerous potential biological targets in plants. NO signaling functions depend on its reactivity. ROI are key modulators of NO in triggering cell death, but the nature of the mechanisms by which this occurs in plants ...
Background:. Despite the development of significant pharmaceutical treatments, morbidity and mortality of chronic heart failure (CHF) patients remain high, patients� quality of life is poor, and their health care utilization is heavy. It is therefore important to find a cost effective non-pharmaceutical treatment to help CHF patients manage the disease. The relaxation response has been found to be effective in managing CHF-related conditions. With its favorable physiological changes, the relaxation response is likely to benefit CHF patients.. Objectives:. 1. To evaluate the effects of a 15-week relaxation response intervention program on improving functional capacity and health-related quality of life as compared with an ongoing 15-week educational program for cardiac disease management, and a control group of usual cardiac care; 2. To identify the costs of conducting the intervention and the cardiac care education and the costs associated with cardiac care services; and to compare cost among ...
is a powerful formula of minerals and herbal extracts for vascular smooth muscle relaxation, endothelial function and for overall circulatory health
The Process of Muscle Relaxation & Contraction. Muscle contraction and relaxation occurs in your body multiple times during the course of a day, especially if you are active. Muscles have fibers, and the fibers are grouped into fascicles, or bundles, which form individual skeletal muscles. There are three states ...
If you can then thats a start, find somewhere where you will be comfortable and able to relax yourself from the toes up over such as bed, yoga mat or even the couch :-) ************************************************************* Imagine you are on that beach drifting somewhere peaceful and undisturbed The sand is so lovely and soft and not…
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Abstract: The kappa-distributed fully ionized plasma with collisional interaction is investigated. The Fokker-Planck equation with Rosenbluth potential is employed to describe such a physical system. The results show that the kappa distribution is not a stationary distribution unless the parameter kappa tends to infinity. The general expressions of collisional relaxation rate of multiple-component plasma with kappa distribution are derived and discussed in specific cases in details. For the purpose of visual illustration, we also give those results numerically in figures. All the results show that the parameter kappa plays a significant role in relaxation rate ...
Mental toughness, relaxation activities, and sleep in sports Study of the relationship between mental toughness, relaxation, and sleep in athletes at different skill levels. Psychologie LAP LAMBERT Academic Publishing (13.10.2011) - ISBN-13: 978-3-8465-2853-2 ...
It is rare that a method appears, disappears, and then re-appears again as is the case of tissue characterization based on relaxation time constants. Yet some years later these obsolete methods were dug out again, grants were given to answer questions which had been discarded 25 years earlier [10, 11]. New pulse sequences and algorithms were developed - researchers tried their luck again. Still, there is no easily explainable causality nor any evidence of a straight connection between these numbers and a distinct pathology. There is no unique signature of distinct malignancies or other pathologies in tissue relaxation times, be it in ex vivo or in vivo measurements. Many people believe that numbers (or, more fashionable, data) are the truth but they do not understand how the num-bers were acquired and what they stand for. Nature doesnt care about numbers. Believing in such postulations many years after they have been dismissed is a sign of scientific naiveté.. Whats wrong in relaxation time ...
Skin relaxation and well-being can be measured by quantitative methods, and modulated by a Tyr-Arg neuropeptide used in topical cosmetic preparations.
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How can you heal quickly - A topic posted by Rolando Vizcarra in the Stress & Relaxation forum. Join the discussion in Workout Trainer for iOS & Android by Skimble.
Many people have major problems with stress. They need to calm down and relax but they just cant seem to find relaxation. As time goes on, the stress will begin to affect their health. Not You!
Guides you through ways to relieve stress. Covers tips to relax your muscle groups such as hands, arms, head, neck, and upper and lower body. Looks at roll breathing to relieve stress. Includes slideshow of roll breathing.
All of us one whenever we were more youthful our bedtime is a time period of restful relaxation designed to free your brain, obvious all ideas, ( Before Bed
Relaxation is the best way to destress the body. Finding the time and manner in which to relax is always the most challenging part.
HSP20 phosphorylation and airway smooth muscle relaxation Mariam Ba1, Cherie A Singer1, Manoj Tyagi2, Colleen Brophy3, Josh E Baker4, Christine Cremo4, Andrew Halayko5, William T Gerthoffer21Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, USA; 2Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, USA; 3Harrington Department of Biochemistry, Arizona State University, Tempe, AZ, USA; 4Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA; 5Departments of Physiology and Internal Medicine, University of Manitoba, Winnipeg, MB, CanadaAbstract: HSP20 (HSPB6) is a small heat shock protein expressed in smooth muscles that is hypothesized to inhibit contraction when phosphorylated by cAMP-dependent protein kinase. To investigate this hypothesis in airway smooth muscle (ASM) we showed that HSP20 was constitutively expressed as well as being inducible in cultured hASM cells by treatment with 1 µM
Alterations in melatonin (MEL) blood levels are associated with several cardiovascular disorders, including hypertension, ischemic heart disease, and heart failure. We recently demonstrated that MEL, acting via MT2-receptors, impairs nitric oxide (NO)-induced relaxation in coronary arteries by inhibiting NO-induced increases in intracellular cGMP levels (JPET 336: 127, 2011). In vascular smooth muscle, PKG1 limits the physiological actions of NO/cGMP signaling by phosphorylating PDE5, thereby increasing PDE5 activity.. Hypothesis: We hypothesized that MEL impairs NO-induced relaxation of coronary arteries by stimulating PKG1-dependent phosphorylation of PDE5, resulting in attenuation of NO-activated BKCa function in coronary smooth muscle cells.. Methods and Results: MEL (10-9 - 10-7 M) inhibited relaxation to the NO-donors (10-10 - 10-4 M), diethylamine-NONOate and sodium nitroprusside (SNP) in isolated porcine coronary arteries (p,0.05; n=5-8), but had no effect on relaxation induced by ...
Although it is known that during endotoxemic shock the use of β-adrenergic agonists can improve organs blood flow independently of cardiac output increase, there is no study in the literature concerning the remodelling of the vascular β-adrenoceptors (β-AR), β1, β2 and β3. Male Sprague-Dawley rats received either 5 mg/kg of lipopolisaccharide (LPS) or the same volume of the vehicle (C) intravenously. Three hours later, the thoracic aorta rings were harvested to perform functional and mRNA expression studies. To take into account the failure of the vascular constriction in sepsis, aortic rings were preconstricted with an appropriate concentration of phenylephrine (α1-adrenergic agonist) in order to obtain 80% of the maximal contraction in both groups. Concentration-relaxation curves were then constructed with several β-AR agonists: isoproterenol (ISO), a non selective agonist; dobutamine (DOBU), salbutamol (SALBU) and SR 58611A (SR) respectively β1-, β2- and β3-AR agonists. The ...
We report the formation of a novel multifunctional metal-organic framework (MOF) based on dysprosium(iii) ions using pyrene-1,3,6,8-tetrasulfonate (pytet)4− as a ligand, synthesized using a soft hydrothermal route. This material shows a two-dimensional network with small channels along a crystallographic axi
I hadnt thought of that and I hate it when people do that. I am sorry if I caused fear in anyone. I think it is interesting that it IS our there on the internet, yet no one on this forum has mentioned it before. I am sure I am not the only one who has seen it with all the research we have all done - but we select things that pertain to us and ignore the things that dont. So, good news is seems frequent compulsive yawning is NOT a part of BFS! Yawning is also a contagious thing and if someone thinks about yawning, it will often happen. If you yawned in one place before, you might be likely to yawn there again...It is an interesting phenomenon. I remember looking up yawning when it was happening well over a year ago if not more, and seeing it was a sign of ALS and being like hmmm, well I know I dont have that disease... And now here I am with all kinds of related fears and perceived symptoms! My own fears have been worse the past week because of this, much stress, and realizing I have no ...
So how can you access relaxations healing powers? Harvard researchers found that yoga, meditation and even repetitive prayer and mantras all induced the relaxation effect. "The more regularly these techniques are practised, the more deeply-rooted the benefits will be," says Jake Toby. Have a go at one or more of the following for 15 minutes once or twice a day. Body scan Starting with your head and working down to your arms and feet, notice how you feel in your body. Taking in your head and neck, simply notice if you feel tense, relaxed, calm or anxious. See how much you can spread any sensations of softness and relaxation to areas of your body that feel tense. Once your reach your feet, work back up your body. Breath focus Sitting comfortably, become aware of your breath, following the sensation of inhaling from your nose down to your abdomen and out again. As you follow your breath, notice your whole body and let tension go with each exhalation. Whenever you notice your mind wandering, come ...
The present study examined age-related changes in the vascular relaxation response to adenine nucleotides in hypertensive and normotensive rats. Aortic ring segments from normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR), age 4-6, 9-10, and 13-14 weeks, were examined for relaxation to adenosine 5-triphosphate (ATP). The extent of ATP-induced relaxation in aortic ring segments with intact endothelium was unchanged with advancing age. Rubbed (endothelium-denuded) ring preparations at the age of 4-6 weeks showed a dose-dependent relaxation similar to that of the unrubbed rings. With advancing age, the ATP-induced relaxation in the rubbed rings decreased and was abolished. The relaxation response did not differ between the SHR and WKY animals at any age, whether the preparations were rubbed or unrubbed. The stable ATP analogue beta,r-methylene ATP induced a relaxation response similar to ATP in rubbed rings at 4-6 weeks of age. In addition, treatment with ...
TY - JOUR. T1 - Inhibitory effects of a fullerene derivative, dimalonic acid C60, on nitric oxide-induced relaxation of rabbit aorta.. AU - Satoh, M.. AU - Matsuo, K.. AU - Kiriya, H.. AU - Mashino, T.. AU - Nagano, T.. AU - Hirobe, M.. AU - Takayanagi, I.. PY - 1997/5/30. Y1 - 1997/5/30. N2 - Dimalonic acid C60 (10(-5) M), a new fullerene derivative, produced an augmentation of phenylephrine-induced tone and reduced both the acetylcholine-induced maximum relaxation and the amplitude of substance P (10(-8) M)-induced relaxation in endothelium-containing thoracic aorta of rabbit; the acetylcholine- and substance P-induced relaxation was restored in the presence of superoxide dismutase (250 U/ml). Dimalonic acid C60 (10(-5) M) did not influence the phenylephrine-induced contractile response in the absence of endothelium, but the acetylcholine-induced relaxation was eliminated by removal of the endothelium. Superoxide anion generation, using hypoxanthine (1 mM)/xanthine oxidase (16 mU/ml), reduced ...
© The Royal Society of Chemistry.The formation and relaxation kinetics of starch-particle complexes were investigated in this study. The combination of cationic nanoparticles in suspension and anionic starch in solution gave rise to aggregate formation which was studied by dynamic light scattering, revealing the initial adsorption of the starch molecules on the particle surface. By examining the stability ratio, W, it was found that even in the most destabilized state, i.e. at charge neutralization, the starch chains had induced steric stabilization to the system. At higher particle and starch concentrations relaxation of the aggregates could be seen, as monitored by a decrease in turbidity with time. This relaxation was evaluated by fitting the data to the Kohlrausch-Williams-Watts function. It was found that irrespective of the starch to particle charge ratio the relaxation time was similar. Moreover, a molecular weight dependence on the relaxation time was found, as well as a more pronounced initial
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Endothelium-derived relaxing factor (EDRF) is supposed to be identical to nitric oxide (NO). A characteristic of NO is its half-life of 6-50 seconds. We report here bioassay experiments suggesting the presence of a long-acting EDRF. An endothelium intact segment of the main bovine pulmonary artery (generator) and an endothelium deprived artery strip (detector) were seperately perfused with Krebs-Henseleit solution. The effluent of the generator was collected and permitted to stand in an open beaker at 37 °C for periods exceeding five minutes. Following this the collected effluent (CE) perfused the histamine precontracted detector, causing significant relaxation. The same degree of relaxation could be observed after storing CE for 80-120 minutes. After reaching steady state generator effluent (G) was directly superfused over the detector (time delay about two seconds) resulting in a more pronounced relaxation. Addition of pharmacological stimuli of EDRF mediated relaxation augmented, addition of ...
Figure 1: Relaxation of bovine pulmonary arteries under basal conditions. A: Representative tracing. Endothelium deprived artery strip (detector) was precontracted with 10-5 M histamine (HA). In the upper panel significant relaxation was induced by perfusing the detector with effluent of an endothelium intact pulmonary artery (generator) which was collected and stored prior to perfusion for five minutes (CE). Following direct superfusion (G), additional relaxation was induced. In control experiments (lower panel) only direct superfusion (G) was performed; W = wash. B: Average relaxation. Data shown as mean +/- SEM ...
In the vascular wall, endothelial nitric oxide synthase (eNOS) produces NO to regulate peripheral vascular resistance, tissue perfusion, and blood pressure. In resistance arteries, eNOS couples with α-globin and, through chemical reactions, modulates NO diffusion needed for vascular smooth muscle relaxation. While α-globin protein alone is known to be unstable, the mechanisms that enable α-globin protein expression remain elusive. Here, Lechauve et al. report that arterial endothelium expresses α hemoglobin-stabilizing protein, which acts as a critical chaperone protein for α-globin expression and vascular function.. ...
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Intagra is used to treat sexual frustration. The formula contains a superpotent ingredient called Sildenafil. It is aimed to amplify smooth muscle relaxation with the help of nitric oxide. The smooth muscle relaxation directs the blood flow into the area of the penis and that causes an erection. | E24rx.com
Voltage sensing domain (VSD) relaxation is a process involving a voltage-independent transition from the activated state into the relaxed state. This process has been shown to shift the voltage dependence for sensing charge movement (sensing current) in the voltage sensitive phosphatase (VSP) known as Ci-VSP and to slow down the deactivation of potassium currents in Shaker and Kv1.2. Given the effect of VSD relaxation on the dynamics of these voltage sensitive proteins, it is thought that the relaxed and the active states are comprised of different set of conformations. Thus, it is possible that these states are sensitive to different physiological parameters. Here, it is shown that VSD activation and relaxation in Ci-VSP display different sensitivity to external pH (pHEXT). Sensing currents of Ci-VSP recorded during activation slowed down as pHEXT was decreased. Noteworthy, the kinetic of deactivating sensing currents was less affected, suggesting that the initial activation of the VSD involved a pHEXT
Proton spin-lattice relaxation of the Zeeman reservoir in the laboratory and rotating frames and of the dipolar reservoir have been studied in ferroelectric colemanite. These studies indicate the presence of two relaxation mechanisms which can be related to motions of the water molecules. The first, referred to as the flip mode and identified with 180 degree flips of the water molecules about their H-O-H bisectrices, is characterized by a correlation time and U-shaped relaxation minimum expected for a normal thermally activated process. The second, referred to as the jump mode and associated with a structural configuration change, produces a cusp-shaped dip in the relaxation over a very small temperature range in the vicinity of the phase transition. (Modified author abstract)*Ferroelectric materials
Your Recommended Daily Allowance for Relaxation Stress is the curse of living in modern times. Everyone suffers from stress. And the stress we suffer takes a heavy toll on our bodies, emotions and minds. Feeling stressed out, worn out by fatigue or just simply having a miserable day, the best thing to do is relax. Watching television may be a form of relaxation for some, but is not a recommended method by experts. When we watch TV we are bombarded with commercials, ads, sounds and images. So how do we achieve relaxation? If there are thousands of ways we can get stressed, one of them is not meeting deadlines, there are also many ways we can relax. In recent studies, experts have determined that heart disease is linked to anger and irritability is linked to mental stress. Too much stress brings about ischemia that can lead to or cause a heart attack. Relaxation takes on added importance in light of this matter. Managing your anger and attitude is significant to heart health, and relaxation can ...
Set in a maze of beautiful and exotic gardens, Ilboru Safari Lodge offers a place of complete relaxation and tranquility, which provides the perfect environment before starting or finishing your North Tanzania safari.. There are 30 chalets at the lodge, all of which have their own en-suite bathroom facilities and private verandas.. The restaurant at Ilboru caters for tastes of all kinds, and special requests can be put in for those with specific dietary needs such as vegetarians and vegans.. During the peak of the day, guests generally enjoy a dip in the outdoor swimming pool, which is the perfect way to cool off from the heat of the African sun.. ...
Last night, Danny and I had our first date since before the surgeries. We loaded up the truck and went to the drive-in movie theater. It wasnt exactly a romantic movie, but The A Team was pretty nostalgic for both of us. Of course, in my opinion, any movie can be romantic when youre at a drive-in! In fact, Danny and I saw two shooting stars! I wont tell you what I wished for on the first shooting star, but the second one I wished that everyone I know, everyone that Ive ever met, would have a moment of complete relaxation. Hopefully, whether or not you knew it, you let out a big sigh of happiness. For the record, I dont believe that telling the wish ruins it. Maybe on birthday cake candles, since that only happens once a year, but regarding spontaneous wishes its fine to tell what youre hopping for. Just my opinion ...
Brody myopathy is an autosomal recessive disorder of skeletal muscle function characterized by painless muscle contracture and exercise-induced impairment of muscle relaxation due to a defect of calcium reuptake. Mutations in the human ATP2A1 gene, that encodes one of the SERCA Ca(2+)-ATPases, cause Brody myopathy ...
Feed your brain some good vibes with Brain.fm. This neurologist-approved audio experience offers a variety of tracks to help your noggin get work done, chill out, or nod off. Set the sound streams to turn off after a preset time or run indefinitely. Save 75% in The Awesomer Shop.. ...
Relaxation dynamics in glycerol-water mixtures: I. Glycerol-rich mixtures. The true Johari-Goldstein [beta]-relaxation of monosaccharides
The sympathomimetic catecholamines produce effects that depend upon their relative specificity for alpha, beta 1 and beta 2 receptors.. Adrenaline: With both alpha and beta effects this will produce an augmentation in heart rate, systolic blood pressure and cardiac output. In addition it produces relaxation of bronchial smooth muscle. However these effects occur at the expense of increased myocardial oxygen demand and reduced perfusion of skin, kidneys and other organs. It is used for its inotropic effect at doses of 0.01-0.02 μg/kg/min titrated according to response.. Noradrenaline: This has predominantly alpha effects but also slight beta effects on the heart. It produces an increase in both systolic and diastolic pressure but its principle effect is to increase peripheral resistance. This is disadvantageous when peripheral resistance is normal as it then produces an increase in resistance and raises cardiac afterload. However it is useful when the peripheral resistance is inappropriately ...
There are many home remedies for tinnitus relief for those seeking natural methods. Emotions, and hence stress, are very important in our lives. This is a factor that enhances hearing tinnitus, so an important aspect of therapy is to minimize it. Even 15 minutes of deep relaxation can relieve stress and improve mood. Good relaxation exercises are: ...
Calcium copper titanate ceramics were fabricated by cold isostatic pressing at various calcination and sintering conditions. Depending on fabrication condition, three electrical responses were observed in the combined modulus and impedance plots, indicating the presence of two Maxwell-Wagner relaxations. These electrical responses show different response to temperature and applied field. The activation energies, as well as the driving force factors, were calculated for these relations. The determined activation energy values are in the range of 0.57 to 0.65 eV. The contribution of Maxwell-Wagner relaxations to the high permittivity of CCTO and related materials is briefly discussed.
You awake extra refreshed, with further energy and Your system is allowed to recover more thoroughly. In addition, becoming perfectly-rested is noted to foster increased focus, as well. Chatting calls for your brain to remain Energetic, which can inhibit your relaxation reaction. Instead, seek to target your respiratory or starting to be extra meditative. As an alternative to heading straight into some more energetic action, try and program your relaxation massage when you have practically nothing intense to perform afterward. When you can nap right after your massage, much the better. A massage will frequently encourage the discharge of a lot of toxins in Your system, which is extremely advantageous. But you need to flush them out as quickly as is possible. Water might help ...