NOTOC__ {{Pseudomyxoma peritonei}} {{CMG}}{{AE}}{{Nnasiri}}{{PSD}} {{SK}} PMP; jelly belly; colloid carcinoma; disseminated peritoneal adenomucinosis (DPAM); malignant appendiceal tumor; malignant large bowel cystadenocarcinoma; malignant large bowel peritoneal carcinomatosis; malignant large bowel tumor; mucinous cyst adenocarcinoma; mucinous cystadenoma; peritoneal carcinomatosis; peritoneal mucinous carcinomatosis (PMCA); pseudomyxoma ovarii ==[[Pseudomyxoma peritonei overview,Overview]]== ==[[Pseudomyxoma peritonei historical perspective,Historical Perspective]]== ==[[Pseudomyxoma peritonei pathophysiology,Pathophysiology]]== ==[[Pseudomyxoma peritonei causes,Causes]]== ==[[Pseudomyxoma peritonei differential diagnosis,Differentiating Pseudomyxoma peritonei from other Diseases]]== ==[[Pseudomyxoma peritonei epidemiology and demographics,Epidemiology and Demographics]]== ==[[Pseudomyxoma peritonei risk factors,Risk Factors]]== ==[[Pseudomyxoma peritonei natural history, complications and ...

Clinical Evidence for Adenoma-Carcinoma Sequence in Primary Retroperitoneal Mucinous Cystadenocarcinoma. PubMed, SCI, Scopus, ESCI, PMC indexed

TY - JOUR. T1 - The first case of primary retroperitoneal mucinous cystadenoma in Korea. T2 - A case report. AU - Min, Byung Wook. AU - Kim, Jong Man. AU - Um, Jun Won. AU - Lee, Eung Seok. AU - Son, Gil Soo. AU - Kim, Seung Joo. AU - Moon, Hong Young. PY - 2004/12. Y1 - 2004/12. N2 - Primary mucinous cystic cystadenomas of the retroperitoneum are very rarely encountered, and there have been only about 30 cases reported in the literature. The histogenesis of primary mucinous cystadenomas is unclear. Most authors suggested that it develops through mucinous metaplasia in a pre-existing mesothelium-lined cyst. Complete surgical excision is the only treatment and it is required for the final diagnosis and cure. We present here a case report of a 38-year-old Korean woman with primary retroperitoneal cystadenoma. It was a thin-walled, multilocular cyst with a dominant loculus that measured 10.0×7.5×5.5 cm3 in size, and to the best of our knowledge, this is the first such case to be reported in in ...

TY - JOUR. T1 - Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas. AU - Maru, Dipen. AU - Wu, Tsung Teh. AU - Canada, Amanda. AU - Houlihan, Patrick S.. AU - Hamilton, Stanley R.. AU - Rashid, Asif. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2004/1/22. Y1 - 2004/1/22. N2 - Appendiceal adenocarcinomas are uncommon, and the genetic alterations present in these tumors are not well characterized. We studied genetic alterations including loss of chromosome 18q (location of DCC, DPC4, and JV-18 genes), and mutations of the DPC4 (SMAD4) and β-catenin genes in 28 appendiceal adenocarcinomas, consisting of 17 mucinous and 11 nonmucinous carcinomas. Chromosome 18q loss was present in 57% (12/21) of appendiceal carcinomas including 54% (7/13) of mucinous and 63% (5/8) of nonmucinous carcinomas. Mutation of the DPC4 gene was present in 14% (three of 22) of the carcinomas occurring in one tumor with chromosome 18q loss and in two with unassessed ...

Biliary cystadenomas are benign but potentially malignant cystic neoplasms, which classically contain mesenchymal stroma similar to ovarian tissue. We report a case of an extra-hepatic biliary cystadenoma with mesenchymal stroma along with a discussi

Pancreatic serous cystadenoma, also known as serous cystadenoma of the pancreas and serous microcystic adenoma, a benign tumour of pancreas. It is usually found in the head of the pancreas, and may be associated with von Hippel-Lindau syndrome. In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm), serous cystic neoplasms are almost always entirely benign. There are some exceptions; rare case reports have described isolated malignant serous cystadenocarcinomas. In addition, serous cystic neoplasms slowly grow, and if they grow large enough they can press on adjacent organs and cause symptoms. Pathologists classify serous cystic neoplasms into two broad groups. Those that are benign, that have not spread to other organs, are designated "serous cystadenoma". Serous cystadenomas can be further sub-typed into microcystic, oligocystic (or macrocystic), solid, mixed serous-endocrine neoplasm, and ...

Goblet cell carcinoid tumor is a rare clinical entity which is usually diagnosed either as acute appendicitis or advanced cancer. Its main characteristic is that the histological findings are between those of adenocarcinoma and typical carcinoid tumor of the appendix. Goblet cell carcinoid tumors appear almost exclusively in the appendix, and prognosis depends mainly on the stage and the subtype of the histological classification. We report three cases of goblet cell carcinoid tumor in the appendix with different clinical presentation and evolution: a 60-year-old male admitted to the emergency room with acute abdominal pain, diagnosed with acute appendicitis and treated with laparoscopic appendectomy; a 65-year-old male undergoing right hemicolectomy to remove a cecal adenoma, with a goblet cell carcinoid tumor found incidentally in the surgical specimen; and a 77-year-old male with acute appendicitis. We discuss the main pathological and clinical findings, and propose a set of guidelines for clinical

Intraductal papillary mucinous neoplasm (IPMN) is a type of tumor that can occur within the cells of the pancreatic duct. IPMN tumors produce mucus, and this mucus can form pancreatic cysts. Although intraductal papillary mucinous neoplasms are benign tumors, they can progress to pancreatic cancer. As such IPMN is viewed as a precancerous condition. Once an intraductal papillary mucinous neoplasm has been found, the management options include close monitoring and pre-emptive surgery.[medical citation needed] Pathologists classify intraductal papillary mucinous neoplasms (IPMNs) into two broad groups - those that are associated with an invasive cancer and those that are not associated with an invasive cancer. This separation has critical prognostic significance. Patients with a surgically resected intraductal papillary mucinous neoplasm without an associated invasive cancer have an excellent prognosis (>95% will be cured), while patients with a surgically resected intraductal papillary mucinous ...

To meet the needs of patients, Canadian surgical and medical oncology leaders in the treatment of peritoneal surface malignancies (psms), together with patient representatives, formed the Canadian HIPEC Collaborative Group (chicg). The group is dedicated to standardizing and improving the treatment of psm in Canada so that access to treatment and, ultimately, the prognosis of Canadian patients with psm are improved.. Patients with resectable psm arising from colorectal or appendiceal neoplasms should be reviewed by a multidisciplinary team including surgeons and medical oncologists with experience in treating patients with psm. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy should be offered to appropriately selected patients and performed at experienced centres.. The aim of this publication is to present guidelines that we recommend be applied across the country for the treatment of psm.. ...

Pancreatic mucinous cystic neoplasm, also mucinous cystic neoplasm of the pancreas and mucinous cystic tumour, is a grouping of cystic neoplasms that arise from the pancreas. They may be benign, malignant or in between. The prognosis of this set of tumours is highly variable and dependent on the specific sub-classification (benign, borderline, malignant). Mucinous cystic neoplasms of the pancreas are defined by the World Health Organization (WHO) as cystic epithelial neoplasms that occur almost exclusively in women; do not communicate with the pancreatic ductal system and which are composed of columnar, mucin-producing epithelium, supported by ovarian-type stroma. This means that these tumors make mucin (a thick sticky fluid), they do not arise in the larger pancreatic ducts, and they have a peculiar supporting stroma (or support structure). Mucinous cystic neoplasms of the pancreas classified as benign, borderline, or malignant, based on histomorphological features which predict their ...

Fallopian Tube Clear Cell Adenocarcinoma Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube Mucinous Adenocarcinoma Fallopian Tube Serous Adenocarcinoma Fallopian Tube Transitional Cell Carcinoma Malignant Ovarian Brenner Tumor Ovarian Clear Cell Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Mucinous Adenocarcinoma Ovarian Seromucinous Carcinoma Ovarian Serous Adenocarcinoma Ovarian Transitional Cell Carcinoma Primary Peritoneal Serous Adenocarcinoma Stage IIA Fallopian Tube Cancer Stage IIA Ovarian Cancer Stage IIB Fallopian Tube Cancer Stage IIB Ovarian Cancer Stage IIC Fallopian Tube Cancer Stage IIC Ovarian Cancer Stage IIIA Fallopian Tube Cancer Stage IIIA Ovarian Cancer Stage IIIA Primary Peritoneal Cancer Stage IIIB Fallopian Tube Cancer Stage IIIB Ovarian Cancer Stage IIIB Primary Peritoneal Cancer Stage IIIC Fallopian Tube Cancer Stage IIIC Ovarian Cancer Stage IIIC Primary Peritoneal Cancer Stage IV Fallopian Tube Cancer Stage IV Ovarian Cancer Stage IV Primary ...

Anderson Cancer Center between January 1992 and December 2004 and who did not meet any of the following exclusion criteria: stage III or IV ovarian cancer, appendectomy as part of a second-look procedure or secondary tumor-reductive surgery, primary appendiceal cancer, primary gastrointestinal malignancy with metastasis to the appendix, incomplete clinicopathologic data, appendicitis as a preoperative diagnosis, primary fallopian tube cancer, primary peritoneal cancer, or documented dual primary tumors ...

BACKGROUND:Low-grade appendiceal mucinous neoplasms (LAMNs) are cytologically low-grade tumors of the appendix and are a frequent cause of pseudomyxoma peritonei. They can become a diagnostic challenge when they metastasize to the ovaries, where they may mimic primary ovarian mucinous tumors. CASE REPORT:We report the case of a patient with very large bilateral ovarian mucinous tumors and a concurrent minute LAMN incidentally discovered in a grossly normal appendix. A primary ovarian tumor was suspected, but histological analysis of the ovaries suggested an appendiceal origin. Immunohistochemical studies were not informative and a consensus regarding the source of the ovarian tumors could not be reached within our department. Subsequent next-generation sequencing of tumors from the right ovary, left ovary, appendix, and matched normal tissue demonstrated identical somatic point mutations in KRAS and GNAS present in all tumors. The patient was diagnosed with metastatic LAMN and did not receive further

TY - JOUR. T1 - Race/ethnic variations in ovarian cancer mortality in the United States, 1992-1997. AU - Howe, Holly L.. AU - Tung, Ko Hui. AU - Coughlin, Steven. AU - Jean-Baptiste, Rachel. AU - Hotes, Joellyn. PY - 2003/5/15. Y1 - 2003/5/15. N2 - Ovarian cancer is reported to be the most fatal malignancy of the female genital tract and the fifth leading cause of cancer deaths among women. In the current study, the authors describe ovarian cancer mortality by race and ethnicity in the U.S. during the years 1992-1997, a period comparable to the ovarian cancer incidence data presented in this supplement.. AB - Ovarian cancer is reported to be the most fatal malignancy of the female genital tract and the fifth leading cause of cancer deaths among women. In the current study, the authors describe ovarian cancer mortality by race and ethnicity in the U.S. during the years 1992-1997, a period comparable to the ovarian cancer incidence data presented in this supplement.. UR - ...

TY - JOUR. T1 - Primary pancreatic cystic neoplasms revisited. Part I. T2 - Serous cystic neoplasms. AU - Sakorafas, George H.. AU - Smyrniotis, Vasileios. AU - Reid-Lombardo, Kaye M.. AU - Sarr, Michael G.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Primary pancreatic cystic neoplasms have been recognized increasingly during the two recent decades and include mainly serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. Serous cystic neoplasms represent about 30% of all cystic neoplasms of the pancreas and are characterized by their microcystic appearance (on imaging, macroscopically, and microscopically) and their benign biologic behavior. Modern diagnostic methodology allows the preoperative diagnosis with an acceptable accuracy. Currently, indications for resection of serous cystic neoplasms of the pancreas include the presence of symptoms, size , 4 cm (because these 'large' neoplasms have a more rapid growth rate and probably will soon become symptomatic), ...

TY - JOUR. T1 - Collision tumor of the appendix. T2 - mucinous cystadenoma and carcinoid. A case report. AU - Dellaportas, D.. AU - Vlahos, Nf. AU - Polymeneas, G.. AU - Gkiokas, G.. AU - Dastamani, C.. AU - Carvounis, E.. AU - Theodosopoulos, T.. PY - 2014. Y1 - 2014. N2 - INTRODUCTION: Mucinous cystadenoma is the most common of benign neoplasms of the appendix and carcinoid is the most common type of primary malignant lesions of the appendix.We report a rare case of a 57-year-old female with combined mucinous cystadenoma and carcinoid tumor of the appendix.Dual carcinoid and epithelial neoplasia is a rare occurrence in the appendix.CASE REPORT: A 57-year-old Caucasian woman presented after incidentally palpating a mass on her right iliac fossa. Imaging modalities revealed a cystic tumor in the right iliac fossa with a diameter of about 8 cm, originating either from the right ovary or the appendix. She underwent laparoscopic surgical exploration, which revealed appendiceal mucocele and ...

Ovarian Epithelial Cancer Treatment India, Ovarian Epithelial Cancer Treatment Cost In India Info On Cost Ovarian Epithelial Cancer Treatment Mumbai Delhi Bangalore India, Ovarian Epithelial Cancer Treatment Hospitals Center Mumbai India, Ovarian Epithelial Cancer Treatment Surgeon India

TY - JOUR. T1 - High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters. AU - Sugio, Kenji. AU - Gazdar, Adi F.. AU - Albores-Saavedra, Jorge. AU - Kokkinakis, Demetrius M.. PY - 1996. Y1 - 1996. N2 - Ductal adenocarcinoma, the most common form of pancreatic cancer in humans, is associated with activation of the K-ras oncogene in ~90% of cases. In contrast, K-ras mutations are found in ,50% of the relatively rare intraductal papillary mucinous tumor (IPMT), which arises in the main pancreatic ducts. Since both adenocarcinomas and IPMTs are believed to arise from ductal cells and progress through similar sequences of morphological changes (i.e. flat hyperplasia, papillary hyperplasia, atypia and carcinoma in situ), it is clear that such progression may not always necessitate activation of the ras oncogene. Experimentally ductal adenocarcinomas of the ...

Although both appendiceal tumor and intestinal endometriosis have been reported as rare causes of abdominal pain, the coexistence of appendiceal mucinous neoplasm and ileal endometriosis has not previously been reported. A 41-year-old Japanese woman presented with a positive fecal occult blood test and a 3-year history of menstruation-related lower abdominal pain. A colonoscopy demonstrated extrinsic compression of the cecum, suggesting a mass arising from the appendix or adjacent structures. Abdominal imaging showed a 6-cm cystic mass with intraluminal thick fluids originating from the appendix. At ileocecal resection for an appendiceal tumor, a 2-cm mass in the terminal ileum was incidentally found, which was included in the surgical specimen. Microscopic examination confirmed a diagnosis of a mucinous neoplasm of the appendix with endometriosis of the terminal ileum. To avoid urgent surgery for subsequent serious events associated with disease progression, appendiceal tumor and intestinal

Serous cystadenoma of ovary with xanthogranulomatous oophoritis: combination of benign ovarian tumour with chronic inflammatory non-neoplastic pseudo-tumour-a rarity

SPEN(Solid and papillary epithelial neoplasm of pancreas) 10-20대 여성(흑인)에서 주로 발생, low malignant potential * CT : large cystic tumor of pancreas * Gross : solitary, large(8-10cm), pseudocapsule cross-section: solid & cystic component 내부에 hemorrhage & necrosis동반 * Micro : uniform eosinophilic granular cytoplasm round to oval nuclei with indistinct nucleoli mitotic rate↓ IPMT(Intraductal papillary mucinous tumor) = mucinous ductal ectasia pancreas head에 주로 생기고 남자에 많다. pancreatitis를 잘 일으키며 ERCP상 duct dilatation내에 filling defect(mucin)으로 나타난다. ERCP에서 ampulla of Vater로 mucin이 흘러내리는 것을 관찰할수 있다. premalignant lesion으로 수술적 절제가 필요하다. mucin fluid에 CA 19-9가 증가해 있다. Cystic neoplasm serous & mucinous cystic neoplasm의 두 종류가 있으며 serous neoplasm은 benign, mucinous neoplasm은 premalignant lesion이다. 둘다 중년 여성에 많고, ...

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an appropriate treatment for select patients with peritoneal carcinomat

Borderline Ovarian Clear Cell Tumor Borderline Ovarian Serous Tumor Cervical Adenocarcinoma Cervical Adenosquamous Carcinoma Cervical Small Cell Carcinoma Cervical Squamous Cell Carcinoma, Not Otherwise Specified Childhood Embryonal Rhabdomyosarcoma Childhood Malignant Ovarian Germ Cell Tumor Endometrioid Stromal Sarcoma Gestational Trophoblastic Tumor Malignant Mesothelioma Malignant Ovarian Epithelial Tumor Melanoma Neoplasm of Uncertain Malignant Potential Ovarian Brenner Tumor Ovarian Clear Cell Cystadenocarcinoma Ovarian Serous Cystadenocarcinoma Paget Disease of the Vulva Recurrent Cervical Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Ovarian Germ Cell Tumor Recurrent Primary Peritoneal Carcinoma Recurrent Uterine Corpus Carcinoma Recurrent Vaginal Carcinoma Recurrent Vulvar Carcinoma Stage I Ovarian Cancer Stage I Uterine Corpus Cancer Stage I Vaginal Cancer Stage I Vulvar Cancer Stage IA Cervical Cancer Stage IA Fallopian Tube Cancer Stage IA Ovarian ...

We encountered two cases of endometrioid carcinoma of uterus with extensive surface epithelial changes (SECs) mimicking serous borderline tumor (SBT) of the ovary. The first case was a well-differentiated endometrioid carcinoma arising in a background of complex atypical hyperplasia. The second case was moderately-differentiated endometrioid carcinoma with squamous and mucinous differentiation. The SECs comprised of thin microapapillae without hierarchal branching, lined by cuboidal cells with eosinophilic cytoplasm and mild to moderate nuclear atypia. These areas were reminiscent of SBTs of ovary, micropapillary type. This report expands the existing spectrum of SECs. Serous borderline tumor of ovary like surface epithelial changes could be misleading if present in an endometrial biopsy or curettings. Therefore, knowledge of this morphologic variation is important.

Signet ring cell carcinoma of the colon and rectum is rare, and most cases are detected at an advanced stage. We present a case of primary signet ring cell carcinoma detected at an early stage by magnifying endoscopy with narrow-band imaging (NBI) and crystal violet staining. A 73-year-old man visited our hospital for screening colonoscopy. Six years previously, he had undergone endoscopic submucosal dissection (ESD) for early gastric cancer. The pathological diagnosis was a well-differentiated adenocarcinoma, invading into the mucosa without lymphovascular invasion. Colonoscopy revealed a flat elevated lesion with a slightly depressed area, 20 mm in diameter, in the cecum. Further, magnifying endoscopy with NBI revealed that the surface pattern was slightly irregular and microvessels had a regular diameter and distribution in the margin of the lesion, but in the central part of the lesion, irregularity in the tumor surface pattern and form as well as in the diameter and distribution of microvessels was

We describe a rare neurological presentation of internal jugular vein thrombosis induced by central venous catheter placement in a patient with cancer. A 71-year-old man gave a 3-week history of dysphagia and dysarthria with left-sided neck pain and headache. He was receiving chemotherapy for appendiceal adenocarcinoma. On examination, he had left 9th-12th cranial neuropathies, manifesting as voice hoarseness, decreased palatal movement, absent gag reflex, weakness of scapular elevation and left-sided tongue wasting. CT scan of neck showed the left subclavian central venous catheter tip was in the left internal jugular vein. Skull base MRI showed thrombus within the left jugular foramen extending intracranially. We diagnosed Collet-Sicard syndrome secondary to thrombosis in the sigmoid-jugular venous complex. His headache and neck pain resolved 2 days after removing the catheter and starting anticoagulation. Collet-Sicard syndrome is an unusual syndrome of lower cranial nerve palsies, often ...

Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate into a frank cancer. Most patients with these tumors are in their 5th and 6th decade and it is more common in women. Most of these tumors occur in the body and tail of the pancreas. As with serous cystadenomas they can usually be definitely diagnosed with modern diagnostic testing. When small (,3cm) and asymptomatic, most experts feel these lesions can be safely observed provided there is close surveillance with CT scans. If the lesion is ,3cm, causing symptoms or obstructing the pancreatic duct they should be surgically excised. Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed.. ...

Answer: Papillary cystadenoma. Histology: The tumor consists of lobules composed of papillary structures lined by cells with abundant to clear cytoplasm. Nuclei appear uniform and small without atypia or mitotic figures. In areas, the tumor is seen projecting within small cystic structures.. Discussion: Approximately 50% of cases of papillary cystadenoma of the epididymis are associated with von Hippel-Lindau disease. Especially in the setting of von Hippel-Lindau disease, the differential diagnosis is between papillary cystadenoma and metastatic renal cell carcinoma as patients with von Hippel-Lindau disease are at increased risk of having renal cell carcinoma. Some cases of papillary cystadenoma are composed of small solid nests of cells separated by a fine, thin vasculature where they can closely resemble renal cell carcinoma. Other areas will show a more papillary configuration with the same clear cytoplasm that is more typical of papillary cystadenoma and would be unusual in clear cell ...

TY - JOUR. T1 - Low grade peritoneal mucinous carcinomatosis associated with human papilloma virus infection. T2 - case report.. AU - Gatalica, Zoran. AU - Foster, Jason M.. AU - Loggie, Brian W.. PY - 2008/10. Y1 - 2008/10. N2 - Pseudomyxoma peritonei is a clinical syndrome characterized by peritoneal dissemination of a mucinous tumor with mucinous ascites. The vast majority of the pseudomyxoma peritonei are associated with mucinous neoplasms of the appendix. We describe a case of pseudomyxoma peritonei associated with mucinous adenocarcinoma of the cervix in a 60-year-old woman. The patient developed low grade mucinous peritoneal carcinomatosis 8 years after hysterectomy for cervical adenocarcinoma. No other primary mucinous tumor was identified and peritoneal carcinomatosis tested positive for high-risk human papilloma virus (HPV), showing both integrated and episomal pattern. HPV has been previously associated with development of cervical carcinomas (both squamous and mucinous) but neither ...

Adenocarcinoma of the Colon Adenocarcinoma of the Rectum Advanced Adult Primary Liver Cancer Carcinoma of the Appendix Gastrointestinal Stromal Tumor Metastatic Gastrointestinal Carcinoid Tumor Metastatic Squamous Neck Cancer With Occult Primary Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Adult Primary Liver Cancer Recurrent Anal Cancer Recurrent Basal Cell Carcinoma of the Lip Recurrent Colon Cancer Recurrent Esophageal Cancer Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity Recurrent Extrahepatic Bile Duct Cancer Recurrent Gallbladder Cancer Recurrent Gastric Cancer Recurrent Gastrointestinal Carcinoid Tumor Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity Recurrent Lymphoepithelioma of the Nasopharynx Recurrent Lymphoepithelioma of the Oropharynx Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity Recurrent Mucoepidermoid Carcinoma of the Oral ...

Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was undertaken in order to compare the combination of carboplatin and pegylated liposomal doxorubicin (LD) with carboplatin and paclitaxel (CP) in this setting. Patients with histologically confirmed recurrent OC, at the time of or more than 6 months after platinum-based chemotherapy, were randomized to six cycles of CP (carboplatin AUC5 + paclitaxel 175 mg/m2, d1q21) or CLD (carboplatin AUC5 + pegylated LD 45 mg/m2, d1q28). A total of 189 eligible patients (CP 96, CLD 93), with a median age of 63 years, median Performance Status (PS) 0 and a median platinum free interval (PFI) of 16.5 months, entered the study. Discontinuation due to toxicity was higher in the CP patients (13.5% versus 3%, P = 0.016). The overall response rate was similar: CP 58% versus CLD 51%, P = 0.309 (Complete Response; CR 34% versus 23%) and there was no statistical difference in time-to

The vermiform appendix is a blind-ended tube that projects from the cecum. The term vermiform comes from Latin and it means worm-shaped. Thus, the vermiform appendix is a projection that is worm-shaped connected to the cecum. The average size of a human vermiform appendix is about 9 cm in length whereas the diameter is generally between 7 and 8 mm. It is often found in the lower right quadrant of the abdomen. Its position corresponds to the so-called McBurney's point. For herbivores, the vermiform appendix is essential since it is responsible for the breaking down of cellulose present in the cell wall of plants. In humans and other animals, it became a redundant process since it has no particular daily function. Nevertheless, it is postulated to be associated with maintaining gut flora, particularly during a recovery from diarrhea.1 ...

U.S., April 14 -- ClinicalTrials.gov registry received information related to the study (NCT03111069) titled 'Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children' on April 6. Brief Summary: The goal of this clinical research study is to find the highest tolerable dose of heated doxorubicin that can be given to patients during surgery with abdominal tumors. The safety of this drug will also be studied. Study Start Date: Study Type: Interventional Condition: Malignant Neoplasms of Mesothelial and Soft Tissue Rhabdomyosarcoma, Pelvic Rhabdomyosarcoma, Abdominal Intervention: Procedure: Abdominal Surgery Resectable Intra-Abdominal/Pelvic Tumors Group: Participants receive peritonectomy, omentectomy, cytoreduction, (complete surgical tumor resection, no gross residual disease). Unresectable Intra-Abdominal/Pelvic Tumors Group: ...

TY - JOUR. T1 - Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. AU - Nakata, Kohei. AU - Ohuchida, Kenoki. AU - Aishima, Shinichi. AU - Sadakari, Yoshihiko. AU - Kayashima, Tadashi. AU - Miyasaka, Yoshihiro. AU - Nagai, Eishi. AU - Mizumoto, Kazuhiro. AU - Tanaka, Masao. AU - Tsuneyoshi, Masazumi. AU - Oda, Yoshinao. PY - 2011/5/1. Y1 - 2011/5/1. N2 - Objectives: Although intestinal-type intraductal papillary mucinous carcinoma (IPMC) is reported to have a better prognosis, few studies have addressed its invasive pattern. The meaning of "minimal invasion" (MI) in IPMC also remains unclear. We investigated the prognosis of intraductal papillary mucinous neoplasm (IPMN) focusing on MI and subtypes. Methods: We evaluated 71 patients with IPMC among a total of 179 patients with resected IPMN. Results: Although 2 of 10 MI-IPMC patients had lymph ...

Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity.: Intraductal papillary mucinous neoplasms represe

Prevalences of diverticulum and low-grade mucinous neoplasm (LGMN) were reported as 0.04-2% and less than 1% in the appendix. In this study, the frequency of diverticulum in LGMN cases, the relationship between diverticula and periappendicular mucin, and the possible role of diverticula in...

TY - JOUR. T1 - Pulmonary epithelioid hemangioendothelioma with prominent signet ring cell features mimicking metastatic adenocarcinoma. AU - Hristova, Elena N.. AU - Krishnamurthy, Savitri. AU - Ro, Jae. AU - Ayala, Alberto. PY - 2003/1/1. Y1 - 2003/1/1. N2 - We report the case of a 65-year-old woman who presented with persistent dry cough and was initially treated for pneumonia without much improvement. Computed tomography of the chest showed a 2.5 cm poorly marginated right infrahilar opacity and multiple ill-defined ground glass opacities scattered throughout the lungs. Computed tomography-guided fine needle aspiration of the right infrahilarmass showed malignant epithelioid cells, many of which were strikingly plasmacytoid with a vacuolated cytoplasm suggesting signet ring cells. A diagnosis of adenocarcinoma with signet ring cell features was made and, in view of the clinical history of multiple masses in the lung, metastatic adenocarcinoma from sites such as gastrointestinal or ...

Splenectomy during cytoreductive surgery in epithelial ovarian cancer Hengzi Sun,1 Xiaoning Bi,1 Dongyan Cao,1 Jiaxin Yang,1 Ming Wu,1 Lingya Pan,1 Huifang Huang,1 Ge Chen,2 Keng Shen1 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Background: The aim of the study was to analyze the underlying causes and application of splenectomy in patients with epithelial ovarian cancer (EOC) and assess its effect on the surgical satisfaction and prognosis of these patients.Materials and methods: Clinical data of patients with ovarian epithelial cancer treated with cytoreductive surgery were collected from 2000 to 2015 at Peking Union Medical College Hospital.Results: A total of 2,882 patients underwent ovarian cancer cytoreductive surgery at

PRIMARY OBJECTIVES: I. To determine the maximally tolerated dose (MTD) of nab-paclitaxel as a single agent administered intraperitoneally via an intraperitoneal catheter.. SECONDARY OBJECTIVES: I. To evaluate the pharmacokinetics of nab-paclitaxel (Abraxane) in the plasma and peritoneum when it is administered directly into the peritoneal cavity. II. To determine the potential pharmacokinetic advantage (favorable ratio of nab-paclitaxel (Abraxane) concentration in the peritoneal cavity vs. plasma) for nab-paclitaxel administered intraperitoneally. III. To determine the progression of peripheral neuropathy in patients treated with intraperitoneal chemotherapy on this study through pre-treatment and sequential evaluation of the Neuropathic Pain Syndrome Inventory and Serial Nerve Conduction Studies.. OUTLINE: This is a dose-escalation study. Patients receive paclitaxel albumin-stabilized nanoparticle formulation given intraperitoneally (IP) on days 1, 8, and 15. Courses repeat every 28 days in the ...

DISEASE CHARACTERISTICS: Histologically confirmed stage III ovarian epithelial cancer or primary peritoneal carcinoma of one of the following cell types: Serous adenocarcinoma Mucinous adenocarcinoma Clear-cell adenocarcinoma Endometrioid Adenocarcinoma (not otherwise specified) Undifferentiated carcinoma Transitional cell Malignant Brenner's tumor Mixed epithelial carcinoma No borderline tumor (tumor of low malignant potential) Underwent prior standard initial cytoreductive surgery within the past 6 weeks Optimally resected disease with no residual site of disease more than 1 cm in greatest dimension Removal of all disease extending beyond the reproductive tract Total hysterectomy and bilateral salpingo-oopherectomy at cytoreductive surgery or in the past. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no ...

TY - JOUR. T1 - Malignant Brenner tumor mimicking a primary squamous cell carcinoma of the cervix. AU - Badve, Sunil. AU - Fehmian, C.. AU - Cass, I.. AU - Goldberg, G. L.. AU - Jones, J. G.. PY - 1999/9. Y1 - 1999/9. N2 - An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. Histology showed a malignant Brenner tumor with abundant squamous differentiation eroding the cervix and simulating a primary cervical malignancy. We describe this case and review the literature on metastatic tumors to the cervix.. AB - An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. Histology showed a malignant Brenner tumor with abundant ...

Acute Lymphoblastic Leukemia Treatment Acute Myeloid Leukemia Treatment Anal Cancer Treatment Basal Cell Carcinoma Treatment Bladder Cancer Treatment Bone & Spine Sarcoma Treatment Bone Cancer Treatment Brain Cancer Treatment Breast Cancer Treatment Cervical Cancer Treatment Chronic Lymphocytic Leukemia Treatment Chronic Myeloid Leukemia Treatment Colon Cancer Treatment Cranial Base Center Treatment Cutaneous Lymphoma Treatment Endocrine Cancers Treatment Endometrial Cancer Treatment Esophageal Cancer Treatment Gallbladder Cancer Treatment Gastrointestinal Cancers Treatment Gastrointestinal Carcinoid Tumors Treatment Genitourinary Cancers Treatment Gliomas Treatment Gynecologic Cancers Treatment Hairy Cell Leukemia Treatment Head & Neck Cancers Treatment Hemophilia Treatment Hodgkin's Lymphoma Treatment Kaposi Sarcoma Treatment Kidney Cancer Treatment Laryngeal Cancer Treatment Leukemia Treatment Lip & Oral Cavity Cancer Treatment Liver Cancer Treatment Lung Cancers Treatment Lymphoma Treatment ...

TY - JOUR. T1 - Serous cystic neoplasm in an intrapancreatic accessory spleen. AU - Hori, Shutaro. AU - Nara, Satoshi. AU - Shimada, Kazuaki. AU - Ojima, Hidenori. AU - Kanai, Yae. AU - Hiraoka, Nobuyoshi. PY - 2010/10/1. Y1 - 2010/10/1. N2 - Serous cystic neoplasm (SCN) of the pancreas is a benign epithelial neoplasm, except in extremely rare malignant cases. Development of SCN in tissues other than the pancreas has been never reported. Here we present the first reported case of SCN in an intrapancreatic accessory spleen (IPAS). A 54-year-old female patient with von Hippel-Lindau (VHL) syndrome was found to have pancreatic tail mass. Pathologically the 25-mm solid mass was an IPAS showing proliferation of clear cuboidal tumor cells without atypia, forming numerous small cysts. The tumor cells were rich in cytoplasmic glycogen and distributed in the splenic tissue almost diffusely. Immunohistochemically, tumor cells were positive for cytokeratins, MUC6, and neuron-specific enolase, and negative ...

Abstract Hyperthermic intraperitoneal chemotherapy (HIPEC) has shown promise in the treatment of ovarian carcinosis. Despite its efficiency for the treatment of peritoneal carcinosis from digestive tract neoplasia, it has failed to demonstrate significant benefit in ovarian cancers. It is therefore essential to understand the mechanism underlying the resistance to HIPEC in ovarian cancers. Mesenchymal Stem Cells (MSC) play an important role in the development of ovarian cancer metastasis and resistance to treatments. A recent study suggests that MSCs may be cytotoxic for cancer cells upon heat shock. In contrast, we describe the protective role of MSC against hyperthermia. Using cytokine arrays we determined that tumor associated MSC (TAMC) secrete pro-tumoral cytokines. We studied the effect of hyperthermia in co-culture setting of TAMC or bone marrow derived-MSC (BM-MSC) associated with ovarian cancer cell lines (SKOV3 and CaOV3) with polyvariate flow cytometry. We demonstrate that hyperthermia does

Histologically, cystoadenomas are characterised by the presence of cysts lined with mucinous cuboidal or columnar epithelium.6 An ovarian-type stroma is seen in 85% of cases and exclusively in females.4 A marsupial pseudocapsule separates the cystadenoma from the biliary epithelium.4 Elevated levels of CA 19-9 and/or CEA have been reported within the cysts themselves.1 2 4 11 12. Although the biliary cystadenoma is a benign entity, malignant transformation can occur, leading to cystadenocarcinoma.4 Sarcomatous transformation has also been described in one case.6 It has been suggested that cystadenocarcinomas arising from biliary cystadenomas with ovarian-type stroma have a relatively indolent course, whereas cystadenomas without ovarian-type stroma have a poorer prognosis.4. Most commonly, on radiologic imaging, these neoplasms appear as multi-loculated, multi-septated intrabiliary neoplasms. They are usually large at the time of presentation, with a mean tumour size of 15 centimetres.4 On CT, ...

A biphasic disease is a disease which has two distinct phases. Anthrax Atopic dermatitis Bartonellosis Dengue fever Insulitis Kyasanur forest disease Leptospirosis Nephropathia epidemica Reye's syndrome Tick-borne encephalitis virus (Western subtype) Theiler's encephalomyelitis virus Trichinosis Tuberculosis West Nile virus Goblet cell carcinoid Antrax Anesthesia and uncommon diseases by Lee A. Fleisher Atopic Dermatitis by Bieber/Leung, Donald Y. M. Leung, page ...

One of the more interesting aspects of small bowel adenocarcinoma is its rarity in comparison to large intestine adenocarcinoma. Even though the small intestine represents approximately 70% to 80% of the length and over 90% of the surface area of the alimentary tract, the incidence of small bowel adenocarcinoma is 30-fold less than the incidence of colon adenocarcinoma. Numerous theories have been proposed to explain the small intestine's relative protection from the development of carcinoma. Proposed protective factors have centered on two concepts. First, the rapid turnover time of small intestinal cells results in epithelial cell shedding prior to the necessary acquisition of multiple genetic defects. Second, the small bowel's exposure to the carcinogenic components of our diet are limited due to rapid small bowel transit time, the lack of bacterial degradation activity that occurs in the small bowel, and the relatively dilute, alkaline environment of the small bowel ...

Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms with the potential for progression to pancreatic cancer. Recognized by the global medical community just over two decades ago, IPMN have gained great epidemiological and clinical relevance thanks to the widespread use of cross-sectional abdominal imaging, which has led to a surge in the number of incidental pancreatic cysts being diagnosed. As our understanding of this disease has improved, we now know that some IPMN have a very elevated risk of cancer and require surgical resection, while others are low-risk lesions and can be followed ...

Mucinous cystadenomas are rare benign epithelial ovarian tumors which are commonly found in middle aged women and are bilateral in 10 percent cases. These tumors are known to grow to massive sizes with historical recordings of removal of a 137.4 kg tumor by O'hanlan in 1994.[2] Our patient had a 21x19.5x13 cm mass that weighed 3.650 kg and could luckily be removed intact despite her history of 3 caesarean sections in the past. Traditionally the epithelial lining of mucinous cystadenomas can be one of 3 types - endocervical, intestinal or the mullerian type. Our patient had a mucinous borderline tumor of the intestinal type with only atypia. The patient fell into FIGO stage 1a for borderline ovarian tumors.[4] The 5 year survival in such patients is usually more than 99%.[5] The cytoplasm of epithelia of low malignant potential mucinous tumours is more basophilic than the epithelium of mucinous cystadenoma. They also show occasional evidence of inflammatory infilitrates. In general in borderline ...

Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Differential considerations Ovarian cystadenofibroma Ovarian cystadenocarcinoma Sclerosing stromal tumor of the ovary Ovarian masses with f...