Signaling by receptor tyrosine kinases (RTKs) typically involves binding of extracellular ligands and subsequent activation of intracellular kinase domain, which in turn mediates autophosphorylation and downstream signal transduction. However, several RTKs, such as ErbB3 (HER3) and Ryk/Derailed, lack key conserved (and catalytically important) residues in their intracellular kinase domain, and are thought to be inactive `pseudo-kinases. Much less is known regarding how these receptor tyrosine `pseudo-kinases mediate transmembrane signaling. The work described in this dissertation attempts to understand the non-canonical signaling by ErbB3 and Ryk/Derailed using a combination of biophysical, biochemical and cell biology methods. ErbB3 is one of four members of the human epidermal growth factor receptor (EGFR) family. ErbB3 signals primarily by heterodimerizing with ErbB2 (HER2) and mediates resistance of tumor cells to EGFR/ErbB2-targeted therapeutics. We have investigated the role of ErbB3 `pseudo

Although loss of attachment to the extracellular matrix (ECM) impairs metabolism and induces apoptosis in cultured epithelial cells, tumor cells are able to avoid death and overcome the metabolic impairments to survive detachment. When apoptosis is inhibited in detached nontransformed mammary epithelial (MCF-10A) cells, the cells show reduced ATP production and glucose uptake associated with decreased signaling through the PI3 kinase (PI3K)-Akt pathway. Expression of the receptor tyrosine kinase ErbB2 enables cells to survive ECM detachment by rescuing the reduced ATP and glucose uptake phenotypes. Grassian et al. report that ECM-detached cells showed decreased flux through the tricarboxylic acid (TCA) cycle, which was characterized by reduced activity of the key TCA cycle enzyme pyruvate dehydrogenase (PDH) and increased pyruvate secretion. Detachment also increased the abundance of the PDH inhibitor PDH kinase 4 (PDK4). ErbB2 suppressed the increase in PDK4 and partially rescued the TCA cycle ...

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TY - JOUR. T1 - EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. AU - Lau, Steven K.M.. AU - Shields, David J.. AU - Murphy, Eric A.. AU - Desgrosellier, Jay S.. AU - Anand, Sudarshan. AU - Huang, Miller. AU - Kato, Shumei. AU - Lim, Ssang Taek. AU - Weis, Sara M.. AU - Stupack, Dwayne G.. AU - Schlaepfer, David D.. AU - Cheresh, David A.. PY - 2012/5/7. Y1 - 2012/5/7. N2 - Receptor tyrosine kinases and integrins play an essential role in tumor cell invasion and metastasis. We previously showed that EGF and other growth factors induce human carcinoma cell invasion and metastasis mediated by integrin αvβ5 that is prevented by Src blockade [1]. MUC1, a transmembrane glycoprotein, is expressed in most epithelial tumors as a heterodimer consisting of an extracellular and a transmembrane subunit. The MUC1 cytoplasmic domain of the transmembrane subunit (MUC1.CD) translocates to the nucleus where it promotes the transcription of ...

The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as …

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MUC17, 0.1 ml. Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.

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Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor HER3 or HER3 or ERBB3 or EC 2.7.10.1) - Drugs in Development, 2021 provides in depth analysis on Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor HER3 or HER3 or ERBB3 or EC 2.7.10.1) targeted pipeline therapeutics. The report provides comprehensive information complete with Analysis by Indications, Stage of Development, Mechanism of Action (MoA), Route of Administration (RoA) and Molecule Type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor HER3 or HER3 or ERBB3 or EC 2.7.10.1) targeted ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

[111 Pages Report] Check for Discount on Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB 4 or p180erbB4 or HER4 or ERBB4 or EC 2.7.10.1) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Receptor Tyrosine Protein Kinase ERBB 4 (...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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TY - JOUR. T1 - Chromosomal Localization of a Human Mucin Gene (MUC8) and Cloning of the cDNA Corresponding to the Carboxy Terminus. AU - Shankar, Viswanathan. AU - Pichan, Prabhasankar. AU - Eddy, Roger L.. AU - Tonk, Vijay. AU - Nowak, Norma. AU - Sait, Sheila N J. AU - Shows, Thomas B.. AU - Schultz, Roger E.. AU - Gotway, Garrett. AU - Elkins, Ronald C.. AU - Gilmore, Michael S.. AU - Sachdev, Goverdhan P.. PY - 1997. Y1 - 1997. N2 - A partial cDNA (pAM1) encoding a major airway mucin glycoprotein with novel tandem repetitive sequence has recently been cloned. In this article, we report additional new sequence derived by 3′-rapid amplification of cDNA ends technique. The sequence corresponds to a stop codon, 3′-untranslated region of 458 bp, a polyadenylation signal, and poly A+ tail, and represents the extreme carboxy terminus of MUC8. A plasmid construct (pAM3) in pBluescript was generated by in-frame ligation of pAM1 to the 479-bp 3′UTR of MUC8. A 5′-end 325-bp fragment of this ...

This year Sands has been partnering with Poco Nido by taking tiny steps to help save babies lives. We are delighted to announce the partnership will continue with Poco Nido who are an award-winning British brand who make footwear for babies and children. The company will be donating £2 from every pair of their gorgeous leather Midi shoes sold between now and the end of January 2020.. Sands partnership with Poco Nido has proved really successful with many of the sizes of their Hot Air Balloon print mini shoes selling out. Catherine Lobley, Founder of Poco Nido, said: We loved working with Sands so much last season that we decided to do it again, but better. For every pair of leather midi shoes purchased between now and January 31st 2020 well donate £2 to Sands. Thats a double donation, for a genuinely worthwhile cause that were proud to be associated with.. Poco Nido Midi shoes are the perfect balance of barefoot and shoe, helping protect little toes while learning to walk. Susy ...

Purpose : Terminally differentiated stratified epithelial cells maintain barrier function at the ocular surface through a specialized protective structure composed of highly O-glycosylated transmembrane mucins. Relatively low levels of N-glycans are found on transmembrane mucins, and their structure and function remains poorly characterized. The purpose of this study was to define the contribution of mucin N-glycans to the ocular surface glycocalyxl barrier. Methods : Transmembrane mucins were purified from stratified corneal epithelial cell cultures using size exclusion chromatography and isopycnic density centrifugation. N-glycans released from mucin isolates were analyzed by liquid chromatography and electrospray ionization mass spectroscopy. N-glycosylation was inhibited using chemical, enzymatic and siRNA (MGAT1) approaches. Plasma membrane proteins were labeled by biotinylation. Lectin blot, immunoblot, and qPCR were used to determine levels of carbohydrate, protein, and mRNA, ...

The present study was undertaken to analyze the role of the MUC4 mucin in pancreatic tumor development and progression. Mucins are generally known to protect surface epithelia from injuries and infections under normal physiological conditions but often display deregulated expression in malignant cells (4 , 6 , 10) . We have previously reported that the human mucin gene MUC4 is aberrantly expressed in pancreatic tumors and cell lines but has no detectable expression in the normal pancreas (10) . The present in vitro and in vivo data reveal that the silencing of MUC4 expression results in altered tumor cell behavior, decreased growth, and a marked reduction in metastatic incidences in an orthotopic mouse model of pancreatic cancer. These results are in support of the previous observations and establish a direct association of MUC4 expression with the disease development.. Down-regulating the expression is one of the convenient and reliable approaches for functional analyses of genes (reviewed in ...

Receptor Tyrosine Protein Kinase ERBB 3 (Proto Oncogene Like Protein c ErbB 3 or Tyrosine Kinase Type Cell Surface Receptor HER3 or HER3 or ERBB3 - Market research report and industry analysis - 11771255

Beatson, Richard, Tajadura-Ortega, Virginia, Achkova, Daniela, Picco, Gianfranco, Tsourouktsoglou, Theodora-Dorita, Klausing, Sandra, Hillier, Matthew, Maher, John, Noll, Thomas, Crocker, Paul R, Taylor-Papadimitriou, Joyce, and Burchell, Joy M. The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nature Immunology 17.11 (2016): 1273-1281 ...

Oh, Ive gone on too long here. Somebody help me! Im turning into that NothingsBiggerThanMyHead guy. But were almost through. There were five other wines in the Loring shipment, including the 2010 Divergence, a 2/3 Cab and 1/3 Mourvedre blend that is the biggest goddam wine Ive had in years. Brian writes that hes currently infatuated with the Spanish wine, El Nido, and its sister wine El Peachykeeno, and this is his California (Paso Robles, to be precise) version of that famous wine. I just couldnt get past its hugeness. At least not the first day. I drank half a glass and suddenly felt like tarpapering my roof. Granted, El Nido has the same sort of effect on me, only Id head to Home Depot and hire some Spanish-speaking guys to tarpaper my roof. So I put the bottle on the kitchen counter and waited. The second day all the fruit started to arrive, sort of like a bad Mardi Gras party. And its loads of very ripe fruit, particularly the Cabernet in the blend. I quite enjoyed it the second and ...

AND TRANSPARENT CAP MULTI TEXT LANGUAGES ON TINS Typical Chemical and Physical Analysis Moisture 3.0

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The high death rate of pancreatic cancer is attributed to the lack of reliable methods for early detection and underlying molecular mechanisms of its aggressive pathogenesis. Although MUC13, a newly identified transmembrane mucin, is known to be aberrantly expressed in ovarian and gastro-intestinal cancers, its role in pancreatic cancer is unknown. Herein, we investigated the expression profile and functions of MUC13 in pancreatic cancer progression. The expression profile of MUC13 in pancreatic cancer was investigated using a recently generated monoclonal antibody (clone PPZ0020) and pancreatic tissue microarrays. The expression of MUC13 was significantly (P , 0.005) higher in cancer samples compared with normal/nonneoplastic pancreatic tissues. For functional analyses, full-length MUC13 was expressed in MUC13 null pancreatic cancer cell lines, MiaPaca and Panc1. MUC13 overexpression caused a significant (P , 0.05) increase in cell motility, invasion, proliferation, and anchorage-dependent or ...

In this chapter we propose a new perspective on the definition of curricula for early childhood educational and care (ECEC) centres. Should children be provided with educational experiences directly geared to the acquisition of specific skills and knowledge? Or is it better to pursue broader educational goals and support the development of childrens full potential? The debate is mostly focused on programmes immediately preceding childrens enrolment in primary school at age 5 or 6. However, where infants and toddlers are concerned, it would be improper to consider the quality of curricula less crucial. We discuss the potential role of the content of experience provided to the younger children while analysing the educational practice in an Italian nido (an early childhood education centre for children under 3 years of age), practices which are based on the assumption that such centres are places of childrens daily life and should provide them with significant social and cognitive experiences. ...

Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed by diverse human carcinomas and certain hematological malignancies (Kufe, 2009). The overexpression of MUC1, as found in human cancers, is associated with the induction of anchorage-independent growth and tumorigenicity (Li et al., 2003). Based on these findings, MUC1 has emerged as an attractive target for the development of anticancer agents. However, the identification of drugs that block MUC1 has been limited by the lack of sufficient information regarding how MUC1 contributes to the growth and survival of malignant cells. In this regard, the MUC1 protein is translated by a single mRNA and then undergoes autocleavage into two subunits that in turn form a heterodimer (Kufe, 2009). The MUC1 N-terminal subunit is the mucin component of the heterodimer that contains the characteristic glycosylated tandem repeats and is expressed on the cell surface in a complex with the MUC1 C-terminal transmembrane subunit (MUC1-C) (Kufe, ...

The average age of onset for most eating disorders sits squarely in early to middle of adolescence. Even with early detection and treatment, many individuals move from adolescence to adulthood with their eating disorder in tow. Many things about the eating disorder shift in this developmental transition. These include the nature of medical risks of the eating disorder, the role of the family in treatment, the tone and content of motivation and ambivalence about change, and the degree to which the individual is free and capable of making their own decisions regarding treatment.

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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model. ...

From El Nido to Cuba, you need to bring the best backpack to help you carry all your stuff. The right bag design allows you to hold your camera, eat food even while on-the-go, and enjoy the many sights and sounds of whichever place youre visiting without the need for carrying extra items using your hands. But, the several available bag designs on the market can make it challenging for travelers, like you, to […]. ...

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Nido de aves (es); nid doiseau (fr); Linnupesa (et); fuglerede (da); ptačí hnízdo (cs); Niu docell (ca); Kuş yuvası (tr); Vogelnest (de); nidificação (pt); bird nest (en); آشیانه (fa); 새의 둥지 (ko); Fûgelnêst (fy); Cuib (ro); 巣#鳥類 (ja); పక్షిగూడు (te); madárfészek (hu); Гнездо птицы (ru); fuglereir (nn); fuglereir (nb); vogelnest (nl); Пташине гніздо (uk); gosala (hi); ᱪᱮᱬᱮ ᱛᱩᱠᱟ (sat); linnunpesä (fi); Құс ұясы (kk); Birdonesto (eo); Птичје гнездо (mk); பறவைக் கூடு (ta) lugar en donde un ave pone e incuba sus huevos y cría a sus polluelos (es); nest for bird eggs (en); పక్షి గూడు (te); பறவை முட்டையிட்டு அடைகாக்கும் இடம் (ta) Nido de las aves, Nido de pájaro, Ave nidificante, Nidificantes, Aves nidificantes, Nidificante, Nido de pajaro (es); 営巣, 鳥類の巣 (ja); Nidificar (pt); ...

Clone REA559 recognizes the human Vβ11 T cell receptor (TCR Vβ11). The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vβ11 is expressed on a subset of α/β T cells. Additional information: Clone REA559 displays negligible binding to Fc receptors. - Lëtzebuerg

Clone REA557 recognizes the human Vβ14 T cell receptor (TCR Vβ14). The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains. TCR Vβ14 is expressed on a subset of α/β T cells. Additional information: Clone REA557 displays negligible binding to Fc receptors - Principat dAndorra

Myeloperoxidase (MPO) is an heterodimeric glycoprotein of 150 kDa with an α2/β2 structure. The two subunits (α and β) have a molecular weight of 55 and 15 kDa, respectively. MPO synthesis occurs in bone marrow at an early stage of myeloid lineage differentiation.

Today, I receive all Gods love for me. Today, I open myself to the unbounded, limitless, overflowing abundance of Gods Universe. Today, I open myself to your Blessings, healing and miracles.Today, I open myself to Gods Word so that I become more like Jesus Everyday. Today, I proclaim that Im Gods Beloved, Im Gods Servant, Im Gods powerful champion, And because I am blessed, I will bless the world, In Jesus Name, Amen.. ...

The 35-year-old federal law regulating tap water is so out of date that the water Americans drink can pose what scientists say are serious health risks - and still be legal. The New York Times analyzed the results of more than 19 million drinking water tests.

Im your local foodie who goes crazy whenever I hear or read the words salmon, prosciutto, and foie gras. I drool every time I get a sniff of coffee and chocolates. And Im at my happiest state when I get to bike around a park and be one with nature. Im a lover of food and travel. And one of the things I love to do most abroad is to visit supermarkets! I love to explore the world, one bite at a time. Get in touch with me at [email protected] ...

Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, ONeal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol. 2017 Mar; 10(2):395-407 ...

Enhancement of the response of pancreatic tumor cells to 12C exposure through the integration of omics, DNA repair inhibition and immune oncology: Michael Story. ...

エピトープ規定戦略を用いた、糖ペプチドネオ抗原の正確な認識のための抗MUC1モノクローナル抗体の研究 [論文内容及び審査の要旨] ...

Mucins are large glycoproteins that cover epithelial surfaces of the body. All mucins contain at least one PTS domain, a region rich in proline, threonine and serine. Mucins are also characterized by von Willebrand D (VWD) domains or SEA domains. We have developed computational methods to identify mucin genes and proteins based on these properties of the proteins. Using such methods we are able to characterize different organisms where genome sequence is available with respect to their mucin repertoire. We have here made a comprehensive analysis of potential mucins encoded by the chicken (Gallus gallus) genome. Three transmembrane mucins (Muc4, Muc13, and Muc16) and four gel-forming mucins (Muc6, Muc2, Muc5ac, and Muc5b) were identified. The gel-forming mucins are encoded within a locus similar to the corresponding human mucins. However, the chicken has an additional gene inserted between Muc2 and Muc5ac that encodes the the α-subunit of ovomucin, a protein similar to Muc2, but it is lacking a PTS

TY - JOUR. T1 - Pattern of mucin gene expression in normal and neoplastic lung tissues. AU - Seregni, E.. AU - Botti, C.. AU - Lombardo, C.. AU - Cantoni, A.. AU - Bogni, A.. AU - Cataldo, I.. AU - Bombardieri, E.. PY - 1996. Y1 - 1996. N2 - This work evaluates the expression in lung cancer of the most well characterized mucin genes (MUC1, MUC2, MUC3) and of the recently described MUC4 in lung tissues, to check a correlation between the expression of any particular gene and this tumor. Hybridization with synthetic oligonucleotides obtained from a part of the sequences of MUC1, MUC2, MUC3 and MUC4, was performed on blotted RNA from 18 lung cancer tissue specimens and from 10 normal tissues samples taken, when possible, from the normal lung counterpart. By means of Northern blot analysis MUC1 revealed to be the most expressed mucin gene in lung cancer, followed by MUC4; by contrast, the expression of MUC2 and MUC3 was almost undetectable in all cancer specimens. The intensity of expression of MUC1 ...

Abstract: Inhibitory cells are essential to fine-tuning the activity of neural circuits. Different classes of interneurons target distinct subcellular compartments of the pyramidal cell. This suggests that there is a differential contribution of each subtype of interneuron in the regulation of the network. In particular, cholecystokinin (CCK) expressing interneurons differ in chemical features and their postsynaptic targets, yet the role of each of these subtypes in the regulation of neuronal network activity is poorly understood. In this study, we describe a subpopulation of CCK interneurons co-expressing the vesicular glutamate transporter 3 (VGlut3) that also shows tyrosine kinase ErbB4 receptor expression. These interneurons are mainly basket cells targeting both, pyramidal cells and Parvalbumin-expressing interneurons in the hippocampus. To address the role of CCK-VGlut3 interneurons in network activity regulation, we combined mouse genetics with a set of different experimental approaches. ...

Introduction: Pancreatic Cancer (PC) is the fourth leading cause of cancer-related deaths in the United States. Over 80% of human pancreatic ductal adenocarcinomas (PDA) overexpress MUC1, a transmembrane mucin glycoprotein. MUC1high tumors are aggressive and patients with such tumors have poor prognosis. Interestingly, MUC1high PDA tumors overexpress cyclooxygenase-2 (COX-2), an inducible pro-inflammatory enzyme known to promote tumor progression and metastasis. Since the cytoplasmic domain of MUC1 (MUC1-C) is critically involved in the signal transduction cascade that promotes tumor progression and metastasis, we hypothesize that MUC1 induces its effect via regulating COX-2 expression and function. Thus, we aim to establish the relationship between MUC1 and COX-2 expression and determine the mechanism by which MUC1 regulates COX-2 expression.. Cell lines:. Human BxPC3 and mouse Panc02 PC cell lines that express low endogenous MUC1 were stably transfected with full length MUC1 (MUC1), empty ...

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Bone is the most common site of metastasis for breast cancer, however the reasons for this remain unclear. We hypothesise that under certain conditions mammary cells possess osteomimetic capabilities that may allow them to adapt to, and flourish within, the bone microenvironment. Mammary cells are known to calcify within breast tissue and we have recently reported a novel in vitro model of mammary mineralization using murine mammary adenocarcinoma 4T1 cells. In this study, the osteomimetic properties of the mammary adenocarcinoma cell line and the conditions required to induce mineralization were characterized extensively. It was found that exogenous organic phosphate and inorganic phosphate induce mineralization in a dose dependent manner in 4T1 cells. Ascorbic acid and dexamethasone alone have no effect. 4T1 cells also show enhanced mineralization in response to bone morphogenetic protein 2 in the presence of phosphate supplemented media. The expression of several bone matrix proteins were monitored

NHE8, the latest characterized NHE isoform in the NHE family, has been shown to participate in transmembrane electrolyte exchange and mucosal protection in the intestine and the kidney (25, 49-51). Although NHE8 is expressed in the epithelial cells in the intestine and the kidney, whether NHE8 is expressed in the ocular surface epithelia remains unknown (25, 49). In the present study, we showed that NHE8 mRNA is expressed in human and mouse eyes. Similar to NHE8 protein localization in the intestinal epithelial cells (49, 50), NHE8 is also located at the plasma membrane of the epithelial cells in the conjunctiva, the cornea, and the lacrimal glands in human and mouse eye tissues. The presence of NHE8 in the ocular surface epithelia suggests a possible role of this protein in ocular function.. Tear film plays a very important role in ocular protection. It is believed that the majority of tears is produced by lacrimal glands, but the ocular epithelial cells, especially conjunctiva, could also ...

Joyce Taylor-Papadimitriou was born in Burnley, Lancashire, in the UK. She obtained her first degree in Biochemistry from the University of Cambridge in 1954. She obtained her PhD with Lou Siminovitch at the University of Toronto. While a postdoc at NIMR in Alick Isaacss lab she was the first to demonstrate that the action of type 1 interferons requires the synthesis of effector proteins. From NIMR she moved to Greece and worked there for eight years. She then returned to London and set up her lab at ICRF (now the CR-UK London Research Institute). Since 1997 she has been head of the CR-UK Breast Cancer Biology Group based at Guys Hospital.. Joyces major research interest has been the phenotype of breast cancers in the context of normal mammary epithelium. She identified and characterised a tumour associated antigen (the MUC1 membrane mucin) which is over expressed and aberrantly glycosylated in breast and ovarian cancer. The first antibody to the mucin, which she developed, has been shown in ...

CD 11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD 11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias ...

Schematic representation for the proposed action of MUC4-NIDO domain in disrupting the basement membrane integrityNormal pancreatic epithelial cells do not expr

There is no question that the older Grace gets the harder it is to send her into surgery because the stakes are that much higher. When she was a newborn or even 4 months ago, she was obviously special to us because she was ours, a precious child God entrusted to us, however with each day that passes we fall deeper in love with her, create more memories, and get to know her personality even more, making the thought of losing her at this point even more gut wrenching. One of the surgery details that we are praying about right now is which surgeon (in Boston) should perform her next surgery. My first choice in surgeons has always been Dr. Del Nido, who is the head of the department and the most experienced by far. When I sent Graces images to Boston and requested that he be the one to review them, they said that he wouldnt be able to review them for 3 weeks. We didnt have 3 weeks to wait because her old local cardiologist (in Texas) was ready to schedule the surgery that she was recommending ( ...

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To explore the diagnostic significance of the most differentially overexpressed secretory mucin MUC4 and MUC5AC for early detection

TYPE OF STAINING:Sialomucin that have acid and neutral mucopolysaccharides stain purple. Normal gastric mucosa will stain only with PAS(red), but intestinal metaplasia will stain purple ...