Results. Sixteen patients (32%) developed ESLD during 173.5 ± 64.7 months of followup. Elevated serum Krebs von den Lungen-6 (KL-6) at initial assessment was highly correlated with ESLD development (p = 0.0002). Receiver-operating characteristic curve analysis revealed that a KL-6 value of 1273 U/ml effectively discriminated patients who developed ESLD from those who did not. Patients with KL-6 , 1273 U/ml were less likely to remain ESLD-free compared with those with lower KL-6 levels (p , 0.0001). Multivariate analysis showed that KL-6 , 1273 U/ml was the most reliable predictor of ESLD development (OR 51.2, 95% CI 7.6-343, p , 0.0001). Finally, the initial KL-6 level correlated with the forced vital capacity (FVC) decline rate (r = 0.58, p , 0.0001). ...
The MACS GMP PepTivator Mucin-1 is a peptide pool that consists mainly of 15-mer peptides. It has been developed for efficient in vitro stimulation and subsequent isolation of Mucin-1-specific CD4+ and CD8+ T cells. - USA
This graph shows the total number of publications written about "Mucin-2" by people in this website by year, and whether "Mucin-2" was a major or minor topic of these publications ...
5097 The murine monoclonal antibody AR20.5 recognizes a hypoglycosylated epitope on the tumor-associated antigen MUC1 (sequence DTRPAP) within the MUC1 tandem repeat peptide sequence that is not accessible on normal epithelial cells. In vitro studies have shown that immune complexes (IC) of AR20.5 and MUC1 enhanced processing of MUC1, including cross-presentation on class I. We have further investigated the activation of MUC1 specific immune responses in MUC1-transgenic (tg) mice, which are tolerant to MUC1 on the CD4 and CD8 T cell level. Mice were immunized with MUC1 alone, AR20.5 alone, IC containing MAb-AR20.5 and MUC1, and appropriate controls. Subcutaneous (s.c.) and intravenous (i.v.) routes were compared at various MUC1 concentrations. MUC1 was affinity purified from the pancreatic cancer cell CFPAC-1. The murine IgG1 AR20.5 antibody was also compared to a human IgG derivative. Mice were monitored for antibodies to MUC1 by ELISA and for T cell responses by IFN-γ intracellular cytokine ...
MUC4 Antibody (monoclonal) (M07), Mouse monoclonal antibody raised against a partial recombinant MUC4. validated in WB, IHC, E (AT2936a), Abgent
Bäckström, M., Link, T., Olson, F. J., Karlsson, H., Graham, R., Picco, G., Burchell, J., Taylor-Papadimitriou, J., and Noll, T. (2003). Recombinant MUC1 with breast cancer-like O-glycosylation produced in large amounts in CHO-K1 cells. Biochemical Journal 376, 677-686 ...
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... is for the quantitative in vitro determination of MUC5B concentrations in serum - plasma - tissue homogenates - other biological fluids.
NSCLC with mutations in the EGF receptor often develop resistance to first-line targeted therapy. The mucin 1 C-terminal (MUC1-C) oncoprotein associates with EGFR and is aberrantly overexpressed in NSCLC. Here in NSCLC cells harboring EGFR mutations, unanticipated findings demonstrate that targeting MUC1-C with stable silencing, expression of a DN mutant, or treatment the MUC1 inhibitor (GO-203) results in downregulation of EGFR signaling and inhibition of growth, clonogenic survival, and tumorigenicity. Of therapeutic relevance, GO-203 and the irreversible EGFR inhibitor afatinib were found to be more effective in combination in inhibiting survival of EGFR mutant NSCLC cells than either agent alone. These findings highlight the novelty of MUC1-C in driving activation of mutant EGFR signaling in NSCLC cells. ...
The genetic heterogeneity of triple-negative breast cancers (TNBC) has made development of targeted therapies challenging. Recent studies have defined an immune-activated TNBC subtype characterized by immune cell infiltration and cytokine signaling, but the genetic drivers of these tumors have not been identified. Barbie and colleagues found that IκB kinase ε (IKBKE), which promotes cytokine production and prosurvival signaling via activation of NFκB and JAK-STAT pathways and has been implicated as a breast cancer oncogene, is aberrantly overexpressed in a subset of TNBCs in the absence of IKBKE gene amplification. Overexpression of IKBKE in these tumors was associated with IL1 activation and lymphocyte infiltration, similar to the immune-activated TNBC subtype. IKBKE expression in TNBC cells was induced by IL1 and resulted in coordinate activation of STAT3 and NFκB signaling and secretion of the protumorigenic cytokines chemokine (C-C motif) ligand 5 (CCL5) and IL6, which promoted the ...
Purpose: TG4010 is a recombinant MVA vector expressing the tumor-associated antigen MUC1 and IL2. We explored the effect two schedules of TG4010 on PSA in men with PSA progression. Patients and...
Cascadian Therapeutics, Inc., formerly Oncothyreon Inc., is a clinical-stage biopharmaceutical company. The Company focuses on the development of therapeutic products for the treatment of cancer. The Companys clinical-stage product candidate includes ONT-380, an orally active and selective small-molecule human epidermal growth factor receptor (HER) 2 inhibitor. The Companys ONT-10 is a therapeutic vaccine targeting the Mucin 1 peptide antigen (MUC1). The Company is engaged in developing preclinical product candidates in oncology using its Checkpoint kinase 1 (Chk1) kinase inhibitor and protocell technology. The Company completed the evaluation of approximately two dosing cohorts in its Phase Ib trial of ONT-10 in combination with the anti-CD27 T-cell agonist antibody varlilumab in collaboration with other company. The Company has completed Phase I trial of ONT-380, with both dose-escalation and expansion components. The Company has initiated Phase Ib trials of ONT-380.
Creative Biolabs provides Mouse Anti-MUC1 DNA-encoded mAb (CBFYM-0430), pVAX1 product for Biopharmaceutical research,preclinical and clinical trials.
Mehr als hundert Fachhochschule Kurse unterrichtet werden, und jedes Schuljahr ist anders. Wenn für einen Kurs suchen, ein college student kann ein breites Spektrum von Themen zur Auswahl.. Die meisten Studenten kommen aus bürgerlichen Familien, so dass die meisten der gemeinsamen Themen abgedeckt sind. Der Lehrplan umfasst Französisch Geschichte, Geographie, Kunst und technische Fächer. Es gibt jedoch mehrere Fächer, in denen Studenten, einschließlich TEFL oder TESOL Kurse spezialisiert ist, und sie werden von Fachleuten mit langjähriger Erfahrung im Unterrichten von Englisch als zweite Sprache gelehrt.. Der Lehrplan wird von den Lehrern entwickelt und wird als Folge ihrer Erfahrungen in der Lehre entwickelt. Die Themen sind seminararbeit deckblatt sorgfältig ausgewählt und dann bearbeitetund die Ergebnisse von den Lehrern gewünscht zu erreichen. Allerdings sind nicht alle Schüler werden von den gleichen Kursen profitieren.. Die Kursmaterialien umfassen ...
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer ...
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by transducing growth and survival signals from cell surface receptors. However, little is known about the structure of the MUC1-C cytoplasmic domain as a potential drug target. Using methods for structural predictions, our results indicate that a highly conserved CQCRRK sequence, which is adjacent to the cell membrane, forms a small pocket that exposes the two cysteine residues for forming disulfide bonds. By contrast, the remainder of the MUC1-C cytoplasmic domain has no apparent structure, consistent with an intrinsically disordered protein. Our studies thus focused on targeting the MUC1 CQCRRK region. The results show that L- and D-amino acid CQCRRK-containing peptides bind directly to the CQC motif. We further show that the D-amino acid peptide, designated GO-203, blocks ...
We sell ELISA, IFA, RIA kits, antibody/antibodies for many antigens and hosts, IgA, IgD, IgE, IgG, IgM. Antibody application for WB, ELISA, IHC-P, IF, FCM.
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5 UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014 ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Mouse polyclonal antibody raised against a partial recombinant MUC5AC. MUC5AC (XP_495860, 351 a.a. ~ 450 a.a) partial recombinant protein with GST tag. (H00004586-A01) - Products - Abnova
PRINCETON - Amerikanische Regierungsbeamte verwenden normalerweise viel Energie darauf, den „Prozess" im Nahen Osten als „Friedensprozess" herauszustellen. Erst in den letzten 18 Monaten der zweiten Amtszeit des Präsidenten bzw. in Folge eines Militäreinsatzes im Nahen Osten haben die Vereinigten Staaten überhaupt begonnen, sich mit „Frieden" auseinanderzusetzen. Dieses Muster scheint auch für die von den USA finanzierte Nahost-Friedenskonferenz in Annapolis (Maryland) nächste Woche zu gelten. Im Unterschied zur Madrider Konferenz nach dem von den Amerikanern angeführten Golfkrieg 1991 erfolgt dieser Versuch nun nach einer empfundenen amerikanischen Niederlage im Irak. Wenn man davon ausgeht, dass die Regierung ihre gegenwärtigen Bemühungen ernst meint, müssen die USA einen Plan B haben, falls die Gespräche scheitern. Die Hauptsorge der Palästinenser ist, in diesem Fall negative Auswirkungen zu vermeiden. Im Gegensatz zum letzten Präsidenten Bill Clinton, der Jassir Arafat für ...
Die Kanna Smart Liquid ist ein ultrareines Alkaloidkonzentrat, das in jeder herkömmlichen elektronischen Zigarette verdampft werden kann. Die Wirkungen setzen sofort und intensiv ein, was diese E-Liquid ideal dafür macht, um Kanna Zug um Zug zu erforschen und die Dosis genau nach Deinem Geschmack anzupassen.. Von den einheimischen Stämmen in Südafrika traditionell seit Tausenden von Jahren verwendet, ist Kanna ein hervorragendes pflanzliches Stärkungsmittel, das einen starken Rausch auslöst. Es wurde historisch von den Kriegern nach der Rückkehr aus der Schlacht verwendet, was ihnen ermöglichte sich zu entspannen und mit der Gemeinde wieder zu verbinden.. ...
Recombinant Human MUC1 protein Protein fragment datasheet (ab80082). Abcam offers quality products including antibodies, assays and other reagents.
MUC16小鼠单克隆抗体[X75](ab10029)可与人样本反应并经WB, ELISA, Flow Cyt, ICC/IF实验严格验证。所有产品均提供质保服务,中国75%以上现货。
MUC16小鼠单克隆抗体[OC125](ab693)可与人样本反应并经IHC, Flow Cyt实验严格验证,被9篇文献引用。所有产品均提供质保服务,中国75%以上现货。
Monoklonale und polyklonale MUC2 Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für MUC2 Antikörper. Hier bestellen.
Mouse monoclonal MUC2 antibody [Ccp58] validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human. Immunogen corresponding to synthetic peptide
Mouse monoclonal MUC1 antibody [PR 4D1] validated for IHC and tested in Human. Referenced in 1 publication. Immunogen corresponding to tissue, cells or virus
ウサギ・ポリクローナル抗体 ab76038 交差種: Hu 適用: WB,ICC/IF…MUC4抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody 製品。国内在庫と品質保証制度も充実。
Mouse Monoclonal Anti-MUC-1 Antibody (E29) [PerCP]. Epithelial Marker. Validated: WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P, IP. Tested Reactivity: Human. 100% Guaranteed.
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Die Europäis-che Union (EU) bildet das größte und gle-ichzeit-ig am eng-sten ver-bun-dene Staaten-bünd-nis der Welt. Über 500 Mio. Men-schen bilden gle-ichzeit-ig den bedeu-tend-sten Wirtschaft-sraum, der sich vom Atlantik bis an die Küste des Schwarzen Meeres erstreckt.Im Gegen-satz zum zweit-en großen Wirtschaft-block USA wer-den aber von den einzel-nen Mit-glied-slän-dern noch sehr unter-schiedliche Inter-essen in der Welt vertreten. Und da sich gle-ichzeit-ig beim Mil-itär eine immer noch sehr sta-tis-che Struk-tur der Stre-itkräfte vor allem bei der Ausstat-tung mit Trans-port-mit-teln zeigt, ist die EU als Ganzes immer noch nicht in der Lage ein weit-eres geostrate-gis-ches Schw-ergewicht wie die Vere-inigten Staat-en zu wer-den. Die aktuelle Euro-Krise tut ihr übriges ...
(25.9.17) Mehr als 100 Jahren lang hielten Forscher eine Kontinuität des inneren Keimblatts (Entoderm) von den einfach aufgebauten Nesseltieren zu den komplex aufgebauten Bilateria (Zweis ...
Toll-ähnliche Rezeptoren gehören zum angeborenen Immunsystem des Körpers. Jenem Teil des menschlichen Abwehrsystems also, dass die unmittelbare Bekämpfung von Eindringlingen übernimmt. Im Normalfall erkennen die Toll-ähnlichen Rezeptoren das Virus indem sie an virale Proteine oder die virale DNA binden und anschließend eine Signalkette starten/in Gang setzen, an deren Ende die antivirale Immunantwort steht.. Idealerweise wird der Erreger dadurch sofort beseitigt. Ein Mechanismus, der beim KSHV und anderen Herpesviren nicht zu funktionieren scheint, denn das Virus kann für immer im Organismus überdauern.. Wie genau es dem Virus gelingt, die angeborene Immunantwort zu verhindern, war bisher unklar. Die Wissenschaftler der HZI-Arbeitsgruppe „Virale Immunmodulation" unter der Leitung von Prof. Melanie Brinkmann konnten nun zeigen, dass KSHV aktiv die Aktivierung des angeborenen Immunsystems verhindert. Obwohl das Virus von den Toll-ähnlichen Rezeptoren erkannt wird, funktioniert die ...
Die solare UV-Strahlung wird mit qualitativ hochwertigen Geräten, so genannten Spektralradiometern, im Wellenlängenbereich von 290 bis 400 Nanometern, also sowohl im UV-B- als auch im UV-A-Bereich gemessen. Aufgrund der geringen Zeitintervalle von sechs Minuten zwischen zwei aufeinander folgenden Messungen können auch kurzzeitige Veränderungen der UV-Strahlung, zum Beispiel an Tagen mit wechselhafter Bewölkung erfasst werden. Die Globalstrahlung (also Strahlung vom UV bis zum Infrarotbereich) wird zusätzlich mit Pyranometern erfasst.. Für die tägliche Berichterstattung ruft die Messnetzzentrale in München-Neuherberg jeweils zur Mittagszeit die aktuellen UV-Daten von allen Stationen ab, wertet die Daten aus und stellt sie in Form der UV-Index-Werte der Öffentlichkeit im Internet zur Verfügung. Am Ende eines jeden Tages werden komplette Datensätze von den Stationen abgerufen, auf Plausibilität geprüft, gesundheitlich bewertet, für die weitere Öffentlichkeitsarbeit aufbereitet und ...
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Herr Prof. Chris Meier wurden von den Mitgliedern der der International Society of Nucleosides, Nucleotides and Nucleic Acids (ISN3A; http://is3na.org) zum Vizepräsidenten gewählt.. ...
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Magen-, Darm, Lungen-, Leber-, Gebärmutterhals-, Eierstock-, Haut-, Lippen-, Brustkrebs oder Lymphom, Melanom, Neuroblastom, Medulloblastom, Ewing-Sarkom, Hirntumore, Leukämie, Plattenepithelkarzinomen im Kopf-Hals-Bereich ...
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McGuckin M.A., Wright G. and Ward B.G. (1991) Expression of a polymorphic epithelial mucin antigen defined by the monoclonal antibody BC2 in ovarian carcinoma: Use of the BC2 antibody for the detection of micrometastases. American Journal of Clinical Pathology, 96 1: 46-52. ...
TY - JOUR. T1 - Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells. AU - Banerjee, Kasturi. AU - Gautam, Shailendra K.. AU - Kshirsagar, Prakash. AU - Ross, Kathleen A.. AU - Spagnol, Gaelle. AU - Sorgen, Paul. AU - Wannemuehler, Michael J.. AU - Narasimhan, Balaji. AU - Solheim, Joyce C.. AU - Kumar, Sushil. AU - Batra, Surinder K.. AU - Jain, Maneesh. PY - 2019. Y1 - 2019. N2 - Mucin 4 (MUC4) is a high molecular weight glycoprotein that is differentially overexpressed in pancreatic cancer (PC), functionally contributes to disease progression, and correlates with poor survival. Further, due to its aberrant glycosylation and extensive splicing, MUC4 is a potential target for cancer immunotherapy. Our previous studies have demonstrated the utility of amphiphilic polyanhydride nanoparticles as a useful platform for the development of protein-based prophylactic and therapeutic vaccines. In the present study, we encapsulated purified recombinant human MUC4-beta ...
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We described the development and characterization of REGN4018, a human full-length bispecific antibody that targets CD3 and the tumor antigen MUC16. REGN4018 could induce potent cytotoxicity in vitro against MUC16-expressing cells and was not hampered by excess amounts of CA-125, which may be present in patients with ovarian cancer.. The characterization of immuno-oncology clinical candidates is often carried out in immunodeficient mice with engrafted human immune cells. These models can be valuable in demonstrating potency, and indeed, we demonstrated efficacy of REGN4018 in such a model with OVCAR-3 cells. However, immunodeficient models have some limitations. For example, the activation status and proliferation rate of human T cells transferred to an immunodeficient xenogenic mouse may be considerably different to those in an autologous immunocompetent environment. Furthermore, these models do not express human MUC16 in nontumor (normal) tissues and thus do not allow for assessment of effects ...
LAA413Hu71, Biotin-Linked Polyclonal Antibody to Mucin 1 (MUC1), Homo sapiens (Human), Labelled antibody, CD227, EMA, H23AG, KL-6, PEM, PEMT, PUM, CA15-3, Cancer antigen 15-3, Carcinoma-associated mucin, Episialin, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Designed by Cloud-Clone Corp.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
154110PRTArtificialsynthetic and modified peptide derived from human MUC1 1Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly1 5 10210PRTArtificialsynthetic and modified peptide derived from human MUC1 2Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly1 5 1039PRTArtificialsynthetic and modified peptide derived from human MUC1 3Ser Ala Pro Asp Thr Arg Pro Ala Pro1 549PRTArtificialsynthetic and modified peptide derived from human MUC1 4Ser Ala Pro Asp Thr Arg Pro Ala Pro1 559PRTArtificialsynthetic and modified peptide derived from human MUC1 5Ala Pro Asp Thr Arg Pro Ala Pro Gly1 569PRTArtificialsynthetic and modified peptide derived from human MUC1 6Ala Pro Asp Thr Arg Pro Ala Pro Gly1 5710PRTArtificialsynthetic and modified peptide derived from human MUC1 7Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser1 5 10810PRTArtificialsynthetic and modified peptide derived from human MUC1 8Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser1 5 1099PRTArtificialsynthetic and modified peptide derived from human MUC1 9Pro Asp Thr Arg Pro Ala Pro Gly ...
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed by diverse human carcinomas and certain hematological malignancies (Kufe, 2009). The overexpression of MUC1, as found in human cancers, is associated with the induction of anchorage-independent growth and tumorigenicity (Li et al., 2003). Based on these findings, MUC1 has emerged as an attractive target for the development of anticancer agents. However, the identification of drugs that block MUC1 has been limited by the lack of sufficient information regarding how MUC1 contributes to the growth and survival of malignant cells. In this regard, the MUC1 protein is translated by a single mRNA and then undergoes autocleavage into two subunits that in turn form a heterodimer (Kufe, 2009). The MUC1 N-terminal subunit is the mucin component of the heterodimer that contains the characteristic glycosylated tandem repeats and is expressed on the cell surface in a complex with the MUC1 C-terminal transmembrane subunit (MUC1-C) (Kufe, ...
Screening of anti-MUC1 antibodies for reactivity with native (ascites) and recombinant (baculovirus) MUC1 and for blocking MUC1 specific cytotoxic T-lymphocytes Article Conference Paper ...