684 Studies found for: Oral Cancer AND Squamous Cell AND cells AND Carcinoma, Squamous Cell AND Oral Cavity Squamous Cell Carcinoma ...

Fingerprint Dive into the research topics of Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: A clinical-pathologic correlation. Together they form a unique fingerprint. ...

Parikh A., Shin J. H., Faquin W., Lin D. T., Tirosh I., Sunwoo J. B. & Puram S. V. (2020). Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma. Journal for ImmunoTherapy of Cancer. 2020, 8 (2). ...

Background The National Comprehensive Cancer Network guidelines recommend that patients with oral cavity squamous cell carcinoma (OSCC) and cT4b disease should be either included in clinical trials or...

TY - JOUR. T1 - Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line. AU - Sakagami, Hiroshi. AU - Sugimoto, Masahiro. AU - Tanaka, Shoji. AU - Onuma, Hiromi. AU - Ota, Sana. AU - Kaneko, Miku. AU - Soga, Tomoyoshi. AU - Tomita, Masaru. PY - 2014/4/1. Y1 - 2014/4/1. N2 - Sodium fluoride (NaF) is used in dentistry as a preventive agent for dental caries because of its ability to remineralize the tooth surface and its antibacterial effect. Although one of its target molecules in bacteria is enolase, its site of action in human cells has not been identified. The aim of this study was to identify target metabolites that are coupled to NaF-induced cytotoxicity in the HSC-2 human oral squamous cell carcinoma cell line. Cell viability, membrane integrity and apoptosis induction were analyzed by MTT assay, trypan blue exclusion and caspase-3 activation, respectively. Cells were treated with a minimal cytotoxic concentration of NaF for various times ...

Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details of the molecular mechanism responsible for cisplatin resistance are still unclear. The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells. A cisplatin-resistant cell line, Tca/cisplatin, was established from a cisplatin-sensitive cell line, Tca8113, which was derived from moderately-differentiated tongue squamous cell carcinoma. Global gene expression in this resistant cell line and its sensitive parent cell line was analyzed using Affymetrix HG-U95Av2 microarrays. Candidate genes involved in DNA repair, the MAP pathway and cell cycle regulation were chosen to validate the microarray analysis results. Cell cycle distribution and apoptosis following cisplatin exposure were also investigated. Cisplatin resistance in Tca/cisplatin cells was stable for two years in cisplatin-free culture medium. The IC50 for cisplatin in Tca

Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details of the molecular mechanism responsible for cisplatin resistance are still unclear. The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells. A cisplatin-resistant cell line, Tca/cisplatin, was established from a cisplatin-sensitive cell line, Tca8113, which was derived from moderately-differentiated tongue squamous cell carcinoma. Global gene expression in this resistant cell line and its sensitive parent cell line was analyzed using Affymetrix HG-U95Av2 microarrays. Candidate genes involved in DNA repair, the MAP pathway and cell cycle regulation were chosen to validate the microarray analysis results. Cell cycle distribution and apoptosis following cisplatin exposure were also investigated. Cisplatin resistance in Tca/cisplatin cells was stable for two years in cisplatin-free culture medium. The IC50 for cisplatin in Tca

The purpose of the present study was to describe the survival of patients diagnosed with oral cavity cancer in Germany. The analyses relied on data from eleven population-based cancer registries in Germany covering a population of 33 million inhabitants. Patients with a diagnosis of oral cavity cancer (ICD-10: C00-06) between 1997 and 2006 are included. Period analysis for 2002-2006 was applied to estimate five-year age-standardized relative survival, taking into account patients sex as well as grade and tumor stage. Overall five-year relative survival for oral cavity cancer patients was 54.6%. According to tumor localization, five-year survival was 86.5% for lip cancer, 48.1% for tongue cancer and 51.7% for other regions of the oral cavity. Differences in survival were identified with respect to age, sex, tumor grade and stage. The present study is the first to provide a comprehensive overview on survival of oral cavity cancer patients in Germany.

Our aim was to document the health-related quality of life (QoL) of patients with squamous cell carcinoma (SCC) of the oral cavity who were treated with chemoradiotherapy, and to compare it with that of patients treated with conventional surgery with or without adjuvant treatment. All patients who presented with SCC of the oral cavity treated with chemoradiotherapy alone at the Royal Brisbane & Womens Hospital between 2000 and 2011 and who were alive without disease were included. Health-related QoL was assessed by the University of Washington QoL questionnaire version 4, and the European Organisation for the Research and Treatment of Cancer (EORTC) QoL questionnaires C30 and HN35. The questionnaires were sent to all survivors. Those who responded to chemoradiotherapy were matched with patients who were treated by conventional surgery with or without adjuvant treatment by age, sex, subsite of tumour, and TNM stage. Sixteen patients completed the questionnaires (8 in each group). There was no ...

TY - JOUR. T1 - Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells. AU - Hsu, Fei Ting. AU - Chang, Betty. AU - Chiang, I. Tsang. AU - Wu, Tai Hsien. AU - Hwang, Jeng Jong. PY - 2014/9/1. Y1 - 2014/9/1. N2 - Background/Aim: Although anticancer effects of sorafenib on renal, liver and colon carcinomas are wellknown, its combination effect with ionizing radiation on oral squamous cell carcinoma (OSCC) is unclear. Herein human SAS cells, an OSCC cell line, were used in order to elucidate this combination effect. Materials and Methods: Both SAS and SAS/nuclear factor kappa-B-luciferase (SAS/NF-κBluc2) cell lines were used in the study. Cell viability, NF-κB activation, and protein expression of NF-κB downstream effectors were determined by 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide assay, NF-κB-luc2 reporter gene system, NF-κB/DNA binding activity and western blotting. Results: Sorafenib significantly increased radiationinduced cytotoxicity and ...

Telomerase is a ribonucleoprotein enzyme that maintains telomere length. Telomerase activity is primarily attributed to the expression of telomerase reverse transcriptase (TERT). It has been reported that introduction of an intact human chromosome 3 into the human oral squamous cell carcinoma cell line HSC3 suppresses the tumorigenicity of these cells. However, the mechanisms that regulate tumorigenicity have not been elucidated. To determine whether this reduction in tumorigenicity was...

4NQO reliably produced preneoplastic and malignant oral cavity lesions, which morphologically and histologically mimic human head and neck cancer. Lesions develop long after 4NQO exposure and without an inflammatory response. Thus, the model should be useful for molecular analysis of neoplastic tran …

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Induction chemotherapy is regarded as an effective way to reduce or downgrade the locally advanced or aggressive cancers, and to improve the chance of eradication of the locoregional lesions by radical surgery and/or radiotherapy. However, there are still debates on the clinical value of induction chemotherapy for patients with advanced and resectable oral squamous cell carcinoma. A prospective, open label, parallel, interventional, randomized control trial on TPF induction chemotherapy indicate there is no difference in overall survival, disease free survival, local regional recurrence free survival and metastasis free survival between experimental group and control group, however, the subgroup analysis proves that the induction chemotherapy of TPF protocol could benefit the patients with cyclinD1 high expression and cN2 locally advanced oral squamous cell carcinoma. （Zhong et al, Randomized Phase III Trial of Induction Chemotherapy With Docetaxel, Cisplatin, and Fluorouracil Followed by ...

TY - JOUR. T1 - PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. AU - Kozaki, Ken Ichi. AU - Imoto, Issei. AU - Pimkhaokham, Atiphan. AU - Hasegawa, Shogo. AU - Tsuda, Hitoshi. AU - Omura, Ken. AU - Inazawa, Johji. PY - 2006/12. Y1 - 2006/12. N2 - Phosphatidylinositol 3-kinases (PI3K) are a group of heterodimeric lipid kinases that regulate many cellular processes. Gene amplification and somatic mutations mainly within the helical (exon 9) and kinase (exon 20) domains of PIK3CA, which encode the 110-kDa catalytic subunit of PI3K and are mapped to 3q26, have been reported in various human cancers. Herein, 14 human oral squamous cell carcinoma (OSCC) cell lines and 108 primary OSCC tumors were investigated for activating mutations at exons 9 and 20 as well as amplifications in PIK3CA. PIK3CA missense mutations in exons 9 and 20 were identified in 21.4% (3/14) of OSCC cell lines and 7.4% (8/108) of OSCC tumors by genomic DNA sequencing. An increase in ...

Backgrounds: Oral squamous cell carcinoma (OSCC) is among the most frequent oral cancers in individuals under 40. Documents have endorsed that a diet enriched with fruit and vegetables can banish the risk of developing major cancers. This study aimed to evaluate the effects of different concentrations of four medicinal herbs including saffron, ginger, cinnamon and curcumin on OSCC cell line. Methods: Having obtained the aqueous extract of the four herbs, they were administered on OSCC cell lines per se and in dual, triple, and quadruple combinations. Their effects were measured in different concentrations and in 24 and 48 hours by using MTT assay. Results: The minimum and maximum effective concentrations were respectively 108 and 217 mg/ml for curcumin with IC30 of 77mg/ml, 108 and 270 mg/ml for ginger with IC30 of 58 mg/ml, 2 and 10 mg/ml for saffron with IC30 of 1.9 mg/ml, and 5 and 40 mg/ml for cinnamon with IC30 of 3.3 mg/ml. The best effect of the combinations was seen for cinnamon-saffron after

Fingerprint Dive into the research topics of Combined Effects of ICAM-1 Single-Nucleotide Polymorphisms and Environmental Carcinogens on Oral Cancer Susceptibility and Clinicopathologic Development. Together they form a unique fingerprint. ...

Bupivacaine inhibits the malignant biological behavior of oral squamous cell carcinoma cells by inhibiting the activation of ERK1/2 and STAT3

TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell carcinoma (OSCC), including oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC). Thus, we hypothesized that TGF-β1rs1982073 polymorphism at the miRNA-187 binding site combined with HPV16 L1 seropositivity may have a joint effect on OSCC susceptibility. We determined the genotypes of TGF-β1rs1982073 and HPV16 status in 325 OSCC subjects and 335 cancer-free controls in the non-Hispanic white population, and used logistic regression models to evaluate the joint effects on OSCC susceptibility. TGF-β1rs1982073 polymorphism (CT/CC genotype) combined with HPV16 L1 seropositivity increased the risk of OSCC via joint effects, particularly in OPSCC subjects who were never-smokers (OR, 165.9; 95% CI, ...

MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction] The Editor-in-Chief and Publisher of OncoTargets and Therapy have been alerted to unacceptable levels of duplication with another published paper: Zhang D, Ni Z, Xu X, and Xiao J. MiR-32 Functions as a Tumor Suppressor and Directly Targets EZH2 in Human Oral Squamous Cell Carcinoma. Medical Science Monitor. 20:2527-2535, 2014.Accordingly, we retract Lin FO, Yao LJ, Xiao J, Liu DF, and Ni ZY. MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma. OncoTargets and Therapy. 2014;7:1583-1591.This Retraction relates to

Cisplatin (CDDP) is widely used to treat oral squamous cell carcinoma (OSCC), however, many patients exhibit acquired drug resistance. Yes-associated protein (YAP) is a transcriptional co-activator of the Hippo pathway that regulates organ size and promotes cell proliferation. YAP overexpression correlates with epithelial-mesenchymal transition and nodal metastasis, resulting in anti-tubulin drug resistance. Whether YAP overexpression is the cause of CDDP resistance in cancer cells is unclear, therefore, we investigated the correlation between YAP expression and CDDP sensitivity. We established three CDDP-resistant cell lines (OSC-19-R, SCCKN-R and HSC-3-R) from the OSCC parental cell lines. We also examined the expression levels of ATP7B, GST-π and ERCC1, which are strongly associated with CDDP resistance, and Hippo pathway-related proteins by western blotting. Using immunocytochemistry, we examined the cellular localization of YAP. Additionally, following knockdown of YAP using short ...

During a comprehensive dental examination, our team will look for signs of oral cancer. Early detection is key with oral cancer. If caught early, most forms of oral cancer are treatable. Our dental team is trained and educated to identify oral cancer.. Everyone is susceptible to the disease, but some groups of people are at a higher risk level than others. Here are the top seven risk factors for oral cancer.. Age. Are you in your mid 40s? Your risk of developing oral cancer increases with age. A noticeable increase is evident in people in their 40s and older. According to the Cancer Treatment Centers of America, the majority of diagnosed cases occur around the age of 62, but the average age is declining. The recent increase in Human Papillomavirus (HPV) related cases is causing more people to be diagnosed for oral cancers between the ages of 52 and 56. As the average age for oral cancer cases decreases, it is vital that you receive regular oral cancer screenings at any age.. Gender. Men are ...

BACKGROUND: Sentinel node biopsy (SNB) is an established method in oral squamous cell carcinoma (OSCC) for staging the cN0 neck and to select patients who will benefit from a neck dissection. Near-infrared fluorescence (NIRF) imaging has the potential to improve the SNB procedure by facilitating intraoperative visual identification of the sentinel lymph node (SN). The purpose of this study was to evaluate the feasibility of fluorescence tracer imaging for SN detection in conjunction with conventional radio-guided technique.. METHODS: Prospective study of patients with primary OSCC planned for tumor resection and SNB. Thirty patients were injected peritumorally with a bimodal tracer (ICG-(99m)Tc-Nanocoll) followed by lymphoscintigraphy and SPECT/CT to define the SNs and their anatomical location preoperatively. SNs were detected intraoperatively with a hand-held gamma-probe and a hand-held NIRF camera.. RESULTS: In 29 of 30 subjects (97%), all preoperatively defined SNs could be identified ...

This study was performed to evaluate their 5-year survival rates and identify the factors affecting the prognosis of oral cancer patients who had undergone surgical treatment only. Among 130 patients who were diagnosed with malignant tumor of oral, maxillofacial, and surgical treated in the Department of Oral and Maxillofacial Surgery at Chonnam National University Hospital within a period from January 2000 to December 2010, for 11 years, 84 patients were investigated who were followed up for more than 5 years after radical surgery; oral cancer is primary and received only surgical treatment. The survival rate according to gender, age, type and site of cancer, TNM stage, cervical lymph node metastasis and its stage, recurrence or metastasis, time of recurrence and metastasis, and differentiation were investigated and analyzed. Overall, 5-year survival rate in patients who received only surgical treatment was 81.2 %, and disease-specific 5-year survival rate was 83.1 %. The disease-specific 5-year

We have identified 131 probe sets, corresponding to 108 known genes, which are highly effective in distinguishing invasive OSCC and normal oral tissue, as well as a list of genes that might be involved in the transformation of normal oral tissue to dysplasia, and of oral dysplasia to invasive OSCC. Although prior studies, including our own, have described global changes in gene transcription that distinguish normal oral epithelium from carcinoma, there is considerable heterogeneity among the lists of genes that have been reported and, to our knowledge, few studies have produced a limited combinations of genes as in the current study with high sensitivity and specificity in distinguishing OSCC from normal oral tissue through rigorous statistical testing and validation with independent data sets, and none had provided prediction models (14). The current study provides prediction models that were generated using rigorous statistical analyses, and the differences in gene expression detected using ...

Our results suggested that NO had a tumoricidal potential against oral cancer cells. NO might exert its cytotoxicity as an effector molecule of activated microphage through at least apoptosis.

OBJECTIVE: Oral squamous cell carcinoma (OSCC) is a common tumor of head and neck cancer. MiR-103 is involved in several tumors. However, the role and

The Oncotarget authors report that human OSCC cells formed tumors that expressed PDPN in mice, and induced PDPN expression in infiltrating host murine cancer associated fibroblasts.

In the present study, we evaluated the proliferative behavior of oral SCC cell lines including cetuximab-sensitive HSC3 and HSC4 and cetuximab-resistant SAS. Notably, all cell lines expressed EGFR in the cell membrane and phosphorylated, regardless of cetuximab sensitivity status.. The monoclonal antibody cetuximab targets the extracellular domain of EGFR with high specificity and affinity (37). Cetuximab blocks ligand binding and thereby inhibits EGFR phosphorylation (9). Thus, cetuximab should inhibit EGFR-dependent cell proliferation. In the present study, proliferation of HSC3 and HSC4 cells was strongly associated with EGFR ligand-EGFR signaling, since proliferation was markedly reduced by the EGFR kinase inhibitor AG1478. Thus, cetuximab prevented EGFR phosphorylation, reducing proliferation of HSC3 and HSC4. These data are consistent with those of a previous report that EGFR biomarker analysis in non-small cell lung carcinoma patients showed that those with higher EGFR expression levels ...

BOSTON-Three species of bacteria were found at significantly high levels in the saliva of oral cancer patients, suggesting that the organisms might serve as markers of the disease.

A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.

Higher nodal yield during definitive surgery for clinically node-negative oral cavity squamous cell carcinoma was associated with improved mortality. 1

Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targets for both treatment and diagnostic purposes. We aimed at investigating the role of PA28α, a proteasomal activator in OSCC. The expression of PA28α was examined in a panel of OSCC cell lines and tissues, associated with oncomine analysis. In a large OSCC patient cohort, the prognostic value of PA28α expression was evaluated. Primary clinical end points were recurrence-free and overall survival rate. Functional involvement of PA28α in OSCC was examined in both in vitro and in vivo models upon specific siRNA knockdown. PA28α was found to be overexpressed in OSCC cell lines and tumor tissues. High expression of PA28α was significantly associated with recurrence and poorer overall survival. Specific knockdown of PA28α inhibited OSCC cell proliferation, migration, invasion in vitro and reduced

This is a 60-year-old male with a history of stage 4B oral cavity squamous cell carcinoma. The patient underwent induction chemo with only partial response; however, following induction chemotherapy, he was noted to have resectable disease. The decision was made to take the patient to the operating room for composite resection of his left buccal lesion including left hemimandibulectomy, left neck dissection, tracheostomy, left fibular free flap, left split-thickness skin graft. Following the surgery, the patient was noted to have good Doppler signal and had good response to the pinprick test; however, one to two hours following transfer to the recovery room, the patient was noted to have lost his Doppler signal. At this point, _____ and there was noted to be decreased blood. Given the concern for possible flap compromise, a ...

Despite the recently reported drop in the overall death rate from cancer, the estimated survival rate and number of deaths from oral cancer remain virtually unchanged. Early detection efforts, in combination with strategies for prevention and risk-reduction, have the potential to dramatically improve clinical outcomes. The identification of non-toxic, effective treatments, including complementary and alternative therapies, is critical if the survival rate is to be improved. Epidemiologic studies have suggested a protective effect from certain plant-derived foods and extracts; however, it has been difficult to isolate and identify the compounds most responsible for these observations. The primary purpose of this study was to investigate the response of human oral squamous cell carcinoma (OSCC) to proanthocyanidin (PAC), a plant-derived compound that may inhibit the progression of several other cancers. Using a series of in vitro assays, we sought to quantify the effects of PAC on OSCC, cervical carcinoma

Here are recent publications with contributions from K2 based on last weeks search on PubMed (and optionally articles that have not been included in previous lists). This time the list includes in total 20 recent publications. The entries appear in the order they were received from NCBI. If you have publications that are not included in this or previous lists, please send the references to Hege F. Berg.. 1. Tyrosine kinase inhibitors and interferon-α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines.. Omsland M, Andresen V, Gullaksen SE, Ayuda-Durán P, Popa M, Hovland R, Brendehaug A, Enserink J, McCormack E, Gjertsen BT.. FASEB J. 2020 Jan 16. doi: 10.1096/fj.201802061RR. [Epub ahead of print]. PMID: 31945226. 2. Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study.. Bjerkli IH, Jetlund O, Karevold G, Karlsdóttir Á, Jaatun E, Uhlin-Hansen L, ...

Oral Cancer Screening Downtown Toronto, Possible Signs of Oral Cancer, Oral Cancer Check-up, Diagnosis and Treatment, Oral Cancer Prevention, Norton Dental Downtown

FOXM1 has vital roles in adult tissue homeostasis, cell proliferation, cell differentiation, apoptosis and aging as well as in the pathogenesis of human cancers (16,17,26). Normal cells show a lower expression of FOXM1 than cancer cells. Dysfunction of FOXM1 inhibits cell differentiation, which may finally lead to the malignant transformation of undifferentiated cells (27). Moreover, upregulated expression of FOXM1 has been observed in a number of cancers including hepatocellular carcinoma, breast cancer, non-small cell lung carcinomas and glioblastomas as well as prostate, cervical and gastric cancer (21,28-33). Recent studies have strongly suggested that overexpression of FOXM1 could be correlated with cancer progression and might be a potential prognostic biomarker for cancer patients (28-33). In addition, the prognostic significance of FOXM1 expression is clearly seen in various cancers including renal, liver, pancreatic and lung cancer, by using The Cancer Genome Atlas or The Human Protein ...

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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless tobacco (ST), alcohol use and chewing of betel quid (BQ) are the main risk factors associated with OSCC development. Infection with highrisk Human papillomavirus (HPV) is an emerging risk factor, particularly for oropharyngeal cancers. Most of the OSCC cases are diagnosed at advanced stages, being one of the factors related to the high mortality rate of this cancer. A better understanding of the molecular biology of OSCC development might lead to improved methods related to detection, assessing prognosis and novel treatments of this malignancy. Over the recent years, microarray-based technologies have become commonly used techniques for analyzing gene expression and chromosomal alterations in human cancers and other disease conditions. These high-throughput technologies enable ...

The tumor suppressor Programmed Cell Death 4 (PDCD4) has been found to be under-expressed in several cancers and associated with disease progression and metastasis. There are no current studies characterizing PDCD4 expression and its clinical relevance in Oral Squamous Cell Carcinoma (OSCC). Since nodal metastasis is a major prognostic factor in OSCC, we focused on determining whether PDCD4 under-expression was associated with patient nodal status and had functional relevance in OSCC invasion. We also examined PDCD4 regulation by microRNA 21 (miR-21) in OSCC. PDCD4 mRNA expression levels were assessed in 50 OSCCs and 25 normal oral tissues. PDCD4 was under-expressed in 43/50 (86%) OSCCs, with significantly reduced mRNA levels in patients with nodal metastasis (p = 0.0027), and marginally associated with T3-T4 tumor stage (p = 0.054). PDCD4 protein expression was assessed, by immunohistochemistry (IHC), in 28/50 OSCCs and adjacent normal tissues; PDCD4 protein was absent/under-expressed in 25/28 (89%)

Infiltrating macrophages in the tumor microenvironment have been reported to promote tumor progression through their interaction with the surrounding cells such as tumor, stromal and immune cells, mediated by the secretion of paracrine factors (4-6). Specifically, TAM infiltration has been reported to be associated with tumor progression and poor prognosis in patients with OSCC (13-15). THP-1 cells differentiated with PMA are widely used as a model to study the function and biology of human macrophages (22). However, THP-1 cells are malignant tumor cells and their characteristics are different from normal macrophages (23). Therefore, the present study used two kinds of macrophages and examined the influence of these cells-derived exosomes on malignant potentials and chemosensitivity of OSCC cells.. The THP-1- and PHM-derived exosomes were rapidly internalized by the OSC-4 cells after their addition to the culture medium and their uptake was time-dependent, which suggested that macrophage-derived ...

Head and neck cancer, including oral squamous cell carcinoma, is the sixth most common cancer worldwide. Although cancer cell invasion and metastasis are crucial for tumor progression, detailed molecular mechanisms underlying the invasion and metastasis of oral squamous cell carcinoma are unclear. Comparison of transcriptional profiles using a cDNA microarray demonstrated that N4BP2L1, a novel oncogene expressed by neural precursor cells, is involved in oral squamous cell carcinoma. Expression of N4BP2L1 in oral squamous cell carcinoma is regulated by activation of miR-448 and is higher than in normal oral mucosa. Knockdown of N4BP2L1 and upregulation of miR-448 significantly reduced the invasive potential of oral squamous cell carcinoma cells. We studied N4BP2L1 expression in 187 cases of oral squamous cell carcinoma and found its overexpression to be significantly associated with nodal metastasis (P = 0.0155) and poor prognosis (P = 0.0136). Expression of miR-448 was found to be inversely associated

Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was performed on 27 patients with OLP, 27 patients with OSCC and 27 healthy volunteers. The serum and saliva VEGF were assayed by ELISA method. Statistical analysis of ANOVA was used. Results:The mean saliva flow rate and serum VEGF in OLP and OSCC patients were significantly lower compared to healthy control group (p|0.05), but there was no significant difference between OLP and OSCC patients. There was no significant difference in mean salivary VEGF among groups. Conclusion:It seems that saliva VEGF may not be a good biomarker for OLP and OSCC.

While the effects of benzo[c]phenanthridine alkaloids (QBA), known mainly as sanguinarine and chelerythrine, on the inhibition of some kinds of cancer cell proliferation have been established, the effect on oral squamous cell is not known. Here, the antitumor activity of sanguinarine was demonstrated using in vitro assay systems in SAS, a human oral squamous cell carcinoma (OSCC) cell line. The anti-proliferative and -invasive effects were confirmed with IC?? values in the concentration range of 0.75-1.0 ?M by MTT assay and invasive assay, respectively. Sanguinarine was also able to suppress cell anchorage-independent growth, whereas it did not affect the cells adhering capabilities. Finally, sanguinarine induced apoptotic cell death by activating caspase and altering the Bcl-2/Bax ratio. Taken together, these results indicate that sanguinarine is a potential inhibitor of tumorigenesis and suggest that it may be valuable in the development of new anticancer drugs for the treatment of ...

Purpose To discuss the expression of S100A4 and E-cad in oral squamous cell carcinoma (OSCC) and their significance.Methods Expression of S100A4 and E-cad was detected by using immunohistochemical SP method in oral squamous cell carcinoma.Correlation between the expression and clinicopathological features was analyzed.Results Expression of S100A4 had positive correlation with lymph node metastasis (P0.05), and no correlation with histological grade(P0.05). Expression of E-cad had positive correlation with histological grade and negative correlation with lymph node metastasis(P0.05). Inverse relationship between S100A4 and E-cad expression was observed in oral squamous cell carcinoma(P0.05).Conclusions E-cad plays an important role in differentiation of OSCC. E-cad and S100A4 is closely related to invasion and metastasis of OSCC. Expression of S100A4 and E-cadherin is significantly associated with tumor progression in oral squamous cell carcinoma,which are valuable markers in predicting biological

TY - JOUR. T1 - High-dose-rate brachytherapy using molds for lip and oral cavity tumors. AU - Unetsubo, Teruhisa. AU - Matsuzaki, Hidenobu. AU - Takemoto, Mitsuhiro. AU - Katsui, Kuniaki. AU - Hara, Marina. AU - Katayama, Norihisa. AU - Waki, Takahiro. AU - Kanazawa, Susumu. AU - Asaumi, Jun-Ichi. PY - 2015/4/8. Y1 - 2015/4/8. N2 - Background: High-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this retrospective study, we evaluated the outcome of this therapy and investigated its feasibility for lip and oral cavity tumors. Methods: Between May 2002 and December 2010, 17 patients (median age, 80.0years) with histologically confirmed squamous cell carcinoma of the lip or oral cavity were treated by means of HDR brachytherapy using the mold technique after external beam radiotherapy (EBRT). Tumor sites included the buccal mucosa in eight cases, the ...

Conclusion: According to the results of this study, the significantly higher levels of salivary acetaldehyde production in oral cancer patients and individuals with poor dental health status may suggest a possible link between increased salivary acetaldehyde production and oral cancer. Improved oral hygiene can effectively decrease the level of salivary acetaldehyde production in oral cavity.. Key words: Oral cancer, salivary acetaldehyde production, oral hygiene, dental health status. Corresponding author: Bülent Eren, M.D., Associate Professor, Pathologist, Forensic Medicine Specialist, Council of Forensic Medicine of Turkey, Bursa Morgue Department; 16010, Bursa, Turkey, tel: +902242220347, fax: +0902242255170, e-mail: [email protected]. Introduction. Excessive alcohol consumption is a significant risk factor for squamous cell carcinoma in the upper aeodigestive tract (UADT)1-7. There is increasing evidence that a majorpart of the tumour-promoting action of alcohol might be mediatedvia ...

DOI: 10.11607/jomi.3045 Purpose: Oral cancer therapy with surgery and radiation is associated with comorbidities; this affects rehabilitation with osseointegrated dental implants. The aim of this systematic review was to evaluate the effect of radiation therapy on osseointegrated dental implant survival in oral cancer patients. Materials and Methods: A review of the literature published between 1990 and June 2012 was conducted. Pertinent studies evaluating the effect of radiation therapy on osseointegration of implants were identified through searches of PubMed, SCIRUS, and Google Scholar. Overall implant survival rates were compared with respect to timing of radiation (prior to or after implantation), site of implant placement (maxilla, mandible, vascularized free flaps, nonvascular bone grafts), radiation dose, time interval between radiation therapy and implant placement, and the effect of hyperbaric oxygen therapy. Results: Thirty-eight articles were eligible for inclusion in the review. ...

Pharmacovigilance Study on Platinum-based Chemotherapeutic Regimens in Oral Cancer Patients: A Prospective Cohort Study, Krishna Murti*,K. Pandey1, R. K. Krishna, M. K. Rastogi, M.

1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359-86 2. Chai RC, Lambie D, Verma M, Punyadeera C. Current trends in the etiology and diagnosis of HPV-related head and neck cancers. Cancer Med. 2015;44:596-607 3. Hong AM, Martin A, Chatfield M, Jones D, Zhang M, Armstrong B, Lee CS, Harnett G, Milross C, Clark J, Elliott M, Smee R, Corry J, Liu C, Porceddu S, Rees G, Rose B. Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma. Int J Cancer. 2013;132:2748-2754 4. Granata R, Miceli R, Orlandi E, Perrone F, Cortelazzi B, Franceschini M, Locati LD, Bossi P, Bergamini C, Mirabile A, Mariani L, Olmi P, Scaramellini G, Potepan P, Quattrone P, Ang KK, Licitra L. Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study. ...

Background: Versican, an extracellular matrix proteoglycan, has been noted to be expressed in several malignant tumours and has been suggested to play an important role in cancer development and tumour growth.. Aims: To investigate whether the versican expression level in the peritumoural stromal tissue of primary oral squamous cell carcinoma (OSCC) predicts relapse-free or disease-specific survival. Also, to study the associations between versican expression and several other clinicopathological variables, as well as tumour cell proliferation.. Methods: Immunohistochemistry was used to study the expression of versican and tumour cell proliferative activity in 139 OSCCs. All pertinent clinical data were collected retrospectively from the hospital records.. Results: In this cohort, versican expression did not correlate with the clinicopathological factors or tumour cell proliferation. In univariate analyses, higher risk for disease recurrence was associated with higher stromal versican expression ...

TY - JOUR. T1 - Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. AU - Snijders, Antoine M.. AU - Schmidt, Brian. AU - Fridlyand, Jane. AU - Dekker, Nusi. AU - Pinkel, Daniel. AU - Jordan, Richard C K. AU - Albertson, Donna. PY - 2005/6/16. Y1 - 2005/6/16. N2 - Genomes of solid tumors are characterized by gains and losses of regions, which may contribute to tumorigenesis by altering gene expression. Often the aberrations are extensive, encompassing whole chromosome arms, which makes identification of candidate genes in these regions difficult. Here, we focused on narrow regions of gene amplification to facilitate identification of genetic pathways important in oral squamous cell carcinoma (SCC) development. We used array comparative genomic hybridization (array CGH) to define minimum common amplified regions and then used expression analysis to identify candidate driver genes in amplicons that spanned ,3Mb. We found genes involved ...

Materials. The following chemicals and materials were obtained from the indicated companies: RPMI-1640, Dulbeccos Modified Eagles Medium (DMEM) from Gibco BRL, Grand Island, NY, USA; fetal bovine serum (FBS), phtharal (MW=134), melphalan, 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT), phenylmethylsulfonyl fluoride (PMSF) from Sigma Chemical Ind., St. Louis, MO, USA); hydroquinone (MW=110), benzoquinone (MW=108), eugenol (MW=164), dimethylsulfoxide (DMSO) from Wako Pure Chemical, Osaka, Japan; peplomycin sulfate from Santa Cruz Biotechnology, Santa Cruz, CA, USA; 5-fluorouracil (5-FU) from Kyowa, Tokyo, Japan; RNase A, Proteinase K, ethidium bromide, agarose S from Nippon Gene Co., Ltd., Toyama, Japan; DNA molecular marker from Bayou Biolabs, Harahan, LA, USA; 6-well plates, 24-well plates, 96-microwell plates from Becton Dickinson, Franklin Lakes, NJ, USA; substrate of caspase-3, DEVD-pNA (p-nitroanilide) from MBL, Aichi Prefecture, Japan; HuMedia-KG2 from Kurabo, Osaka, ...

Background & Objectives: Intra-tumoural heterogeneity (ITH) displayed by tumour cells represents a diagnostic challenge when assessing tumour mutational profile aimed to the delivery of effective targeted therapies. In Oral Squamous cell carcinoma (OSCC), ITH has been reported both in tumour cells and in related adjacent mucosa. The presence of genetic heterogeneity in the adjacent mucosa can be interpreted as evidence of the field cancerization phenomenon (field het- erogeneity, FH). Aim of this study was to investigate the clinical impact of ITH and FH on loco regional control. Methods: Ten OSCC patients who received radical surgery and staged T2-T4 (5 recurrent and 5 non-recurrent) were enrolled in this study. Multiple areas were sampled from the bulk of the tumour and the adjacent non-neoplastic mucosa. NGS mutational analysis of 10 OSCC driver genes were investigated and used to calculate ITH and FH among differ- ent area of the tumour. Results: Mutational analysis highlighted that a ...

Background: We investigated the immunohistochemical expression of Arp2/3 complex in 88 oral squamous cell carcinomas (OSCCs) and correlated it with the tumor type and grade. Materials and methods: This is a retrospective study of 88 cases of OSCCs (9 verrucous carcinomas, 4 carcinomas in situ, 37 well differentiated OSCCs, 32 moderately differentiated OSCCs, and 6 poorly differentiated OSCCs), stained with mouse monoclonal antibodies for Arp2 and Arp3. Staining was graded according to the extent of positivity by two observers. Results: Arp2 positivity was seen in 79 (89.77%) cases and Arp3 positivity in 78 (88.63%) cases. In positive cases, Arp2 expression was graded as (+) in 12.5%, (++) in 28.4% and (+++) in 48.86% of the cases; Arp3 was graded as (+) in 36.36%, (++) in 30.68% and (+++) in 21.59% of the cases. Conclusion: Expression of Arp2 and Arp3, indicative of the formation of the Arp2/3 complex, was seen in most OSCCs examined. Although no statistically significant correlation was found between

TY - JOUR. T1 - Cytostatic effect of inostamycin, an inhibitor of cytidine 5′-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG). T2 - Inositol transferase, on oral squamous cell carcinoma cell lines. AU - Baba, Yuh. AU - Tsukuda, Mamoru. AU - Mochimatsu, Izumi. AU - Furukawa, Shigeru. AU - Kagata, Hiroko. AU - Nagashima, Yoji. AU - Koshika, Shinri. AU - Imoto, Masaya. AU - Kato, Yasumasa. N1 - Funding Information: We thank Dr E. W. Thompson (St Vincents Institute of Medical Research, Fitzroy, Australia) for preparation of the manuscript. A part of this study was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, and Science of Japan.. PY - 2001. Y1 - 2001. N2 - Inostamycin, which was recently isolated from Streptomyces sp. MH816-AF15 as an inhibitor of cytidine 5′-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, caused a G1-phase accumulation in the cell cycle of small cell lung carcinomas. To investigate whether the cytostatic effect of inostamycin is ...

Squamous cell carcinoma accounts for 90% of all oral cancers. It may affect any anatomical site in the mouth, but most commonly the tongue and the floor of the mouth. It usually arises from a pre-existing potentially malignant lesion, and occasionally de novo; but in either case from within a field of precancerized epithelium. The use of tobacco and betel quid, heavy drinking of alcoholic beverages and a diet low in fresh fruits and vegetables are well known risk factors for oral squamous cell carcinoma. Important risk factors related to the carcinoma itself that are associated with a poor prognosis include large size of the tumour at the time of diagnosis, the presence of metastases in regional lymphnodes, and a deep invasive front of the tumour. Squamous cell carcinoma is managed by surgery, radiation, and chemotherapy singularly or in combination; but regardless of the treatment modality, the five-year survival rate is poor at about 50%. This can be attributed to the fact that about two-thirds of

During a comprehensive dental examination, our team will look for signs of oral cancer. Early detection is key with oral cancer. If caught early, most forms of oral cancer are treatable. Our dental team is trained and educated to identify oral cancer.

Introduction: Squamous cell carcinoma of the oral cavity is one of the most important and common types of head and neck malignancy, with an estimated rate of 4% among all human malignancies. The aim of this study was to determine the association between expression of matrix metalloproteinase 2 and 9 and the clinicopathological features of oral squamous cell carcinoma (OSCC). Materials and Methods: One hundred existing samples of formalin-fixed paraffin embedded specimens of OSCC were evaluated by immunohistochemistry staining for matrix metalloproteinase 2 and 9 antibodies. Samples were divided into four groups: negative, |10%, 10-50%, and |50%. Patient records were assessed for demographic characteristics such as age and gender, smoking and family history of OSCC as well as tumor features including location, differentiation, stage and lymph node involvement. Results: In this study, 58 patients (58%) were male and 42 (42%) female. The mean age of patients was 60.38±14.07 years. The average number

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer; it involves damage to oral epithelial cells due to accumulation of multiple genetic mutations in the cells. OSCC remains major cause of morbidity and mortality in patients with head and neck cancers. Tobacco, smoking, alcohol consumption alone or with chewing tobacco, and betel quid are potential carcinogens contributing to the high occurrence of OSCC. Current treatment modalities for OSCC like chemoradiotherapy, surgery, EGFR inhibitors and COX-2 inhibitors, and photodynamic therapy have led to the major problems related to non-specific cell death. Nanoengineered systems offer solutions to these problems that not only minimize the major drawbacks of nonspecific cell death but also maximize the efficacy of the cancer therapeutic agents. Various efficacious nanotechnology-based carrier systems are being widely investigated for their potential in OSCC treatment: polymeric nanoparticles, polymeric micelles, nanoemulsions ...

Oral squamous cell carcinoma is the most common malignant neoplasm of oral mucosa, representing more than 90%. Tobacco and alcohol has been considered as the classical risk factors. Human papilloma Virus has been proposed as an etiological risk factor since 2007. Thirty five cases diagnosed with OC their ages and gender matched with controls were enrolled in this study. Fifty-five un-stimulated whole saliva samples (35 OC and 20 apparently health subjects) were collected. DNA was purified from exfoliate cells to amplify HPV-DNA using HPV-L1 gene sequence primers by polymerase chain reaction (PCR) method, the genotyping was performed using direct sequencing method. Mean age was 52.23±13.73 years in cases (range: 17-70 years) while in controls was 50.55±12.5 years (range: 24-74 years).Forty-six percent (16/35) of OC patients was positive for detection of HPV DNA (P,0.001). The most frequent type in patient group was HPV-18 type accounting for (31%) of cases (P,0.05). The prevalence rate of HPV ...

The worldwide annual incidence of oral squamous cell carcinoma (OSCC) is over 300,000 cases with a mortality rate of 48%. This cancer type accounts for 90% of all oral cancers, with the highest incidence in men over 50 years of age. A significantly increased risk of developing OSCC exists among smokers and people who consume alcohol daily. OSCC is an aggressive cancer that metastasizes rapidly. Despite the development of new therapies in the treatment of OSCC, no significant increase in 5-year survival has been recorded in the past decades. The latest research suggests focus should be put on examining tumor stroma activation within OSCC, as the stroma may contain cells that can produce signal molecules and a microenvironment crucial for the development of metastases. The aim of this review is to provide an insight into the factors that activate OSCC stroma and hence faciliate neoplastic progression. It is based on the currently available data on the role and interaction between ...

Oral squamous cell carcinoma: like owner, like cat Links between lifestyle and oral cancers in cats Source: Laura Snyder The Veterinary Journal vol

Background: Expression of p53, cyclin D1, p21 (WAF1) and Ki-67 (MIB1) was evaluated in oral squamous cell carcinoma (OSCC) to test whether levels of these markers at invasive tumour fronts (ITFs) could predict the development of local recurrence. Materials and Methods: Archived paraffin-embedded specimens from 51 patients with T1/T2 tumours were stained immunohistochemically and analysed quantitatively. Local recurrence-free survival was tested with Kaplan-Meier survival plots (log-rank test) using median values to define low and high expression groups and with a Coxs proportional hazards model in which the expression scores were entered as continuous variables. Results: The assessment of expression of all markers was highly reliable, univariate analysis showing that patients with clear surgical margins, with low cyclin D1 and high p21 expression at the ITF had the best local recurrence-free survival. Multivariate analysis showed that these three parameters were independent prognostic factors but that

Foy, J-P. ; Bertolus, C. ; Michallet, M-C. ; Deneuve, S. ; Incitti, R. ; et. al. The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade. In: Annals of Oncology, (2017 ...

Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of ...

Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of ...

Pris: 659 kr. Häftad, 2013. Skickas inom 10-15 vardagar. Köp Incidence of Second Primary in Oral Squamous Cell Carcinoma av Baliga Mohan, Shenoy Nandita, Bhambar Rohan på Bokus.com.

Lymph node density (LND) ≧0.07 has been reported to be a significant predictor of shorter survival in oral squamous cell carcinoma (OSCC) patients with p...

Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.

Background Oral squamous cell carcinoma (OSCC) is one of the most dangerous cancers in the body, producing serious complications with individual behaviors. Many different pathogenetic factors are...

Expression and clinical significance of AXL and NEK2 genes in oral squamous cell carcinoma (OSCC), Chengyong Wang, Chuanqing Mao, Yongzhen Lai, Weihui Chen

Background: Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring system should be robust and well validated, and intra‐ and interrater agreement can be used as a tool to visualize the strength of reproducibility. Methods: Here, we present an intra‐ and inter‐observer study on evaluation of OSCC using some of the most common histopathological parameters. The observers were from different Norwegian university hospitals, and calibration to ensure accuracy was first performed. Percentage of the agreement was calculated for the score made by the individual observer at different times, as well as between pairs of observers. Results: The evaluation made by the same observer at two different time points (intrarater) correlated better than observations made by different participants (interrater). In an attempt to increase the rate of agreement, ...

Background and objectives: Oral squamous cell carcinoma (OSCC) is regarded as a catastrophe of modern age which affecting millions of people around th..

environments, as well as reviews evaluating, comparing and synthesising these results. Despite a broad base of evidence, there remains no clear academic consensus with regard to the relationship between alcohol-containing mouthwashes and oral squamous cell carcinoma. This review aims to present and evaluate the evidence for and against any association.. Conclusion. While there is a lack of consistent evidence, it is advisable for clinicians to promote the use of non-alcoholic mouthwashes in order to minimise any potential increase in risk, and discourage long-term use of high alcohol-containing products.. ...

Context: Early detection of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSMF) transforming into malignancy can drastically improve the treatment outcomes and prognosis. Carcinoma development is an intricate complex mechanism and the multifactorial causation makes it more difficult to find specific prognostic and therapeutic biomarkers. Thus, the development of newer diagnostic and predictive approaches that are less invasive, economical and amenable to repeated sampling is imperative. Serum C-reactive protein (CRP) serves a useful marker for prognosis and monitoring of oral potentially malignant disorders (OPMDs) including OSMF as well as OSCC. Secreted by hepatocyte as an acute inflammatory marker, various studies have shown association between serum CRP and presence of OPMDs, as well as with presence and prognosis of OSCC. Aims: The aim of this study was to measure and compare serum CRP levels in patients with OSMF and OSCC as compared to healthy individuals and to ...

The aim of this study was to compare microbiological, histological, and mechanical findings from tissues around osseointergrated dental implants in patients who had undergone tumour resection and subsequent bone grafting with non bone grafted patients without a history of oral cancer and to develop an effective tool for the monitoring of the peri-implant tissues. A third aim was to assess and compare the masticatory function of the two patient groups after reconstruction with dental implants.

Platinum-based chemotherapy is one of the most common therapies employed in oral cancer treat-ment. This is a prospective cohort study to analyse the ..

The group analyzed the effects of IL-6 on radiosensitivity and DNA damage following X-ray irradiation on two OSCC cell lines and OSCC tissue samples with radioresistant cells. They demonstrated that increased levels of IL-6 resulted in suppressed radiation induced cell death and that blocking IL-6 signalling sensitized tumor cells to radiation.. Overall, the radio-resistant effects of IL-6 were associated with decreased DNA damage following radiation exposure. In addition, the team investigated the role of the Nrf2-antioxidant pathway and highlighted that IL-6 interacts with the Nrf2-antioxidant pathway in order to provide protection from radiation therapy to cancer cells.. One of research group leaders Hideki Nakayama (Kumamoto University) commented: This interaction and the resulting protection from oxidative damage that we have discovered here is very interesting. We hope new therapies that target IL-6 will give us an advantage over many types of radiation-resistant cancers.. Although they ...

Tobacco and alcohol use are major risk factors for oral cancer. A total of 20% to 30% of cases of oral cancer worldwide are attributable to cigarette smoking. In the United States, up to 75% of cases of oral cancer may be attributable to tobacco and alcohol use. Additional risk factors include male sex, older age, use of betel quid, ultraviolet light exposure, infection with Candida or bacterial flora, and a compromised immune system. Sexually transmitted oral HPV infection (HPV-16) has recently been recognized as an increasingly important risk factor for oropharyngeal cancer. In the United States, the prevalence of oropharyngeal cancer due to oral HPV infection is probably as high as 80% to 95%. The prevalence of oral HPV infection is associated with age, sex, number of sexual partners, and number of cigarettes smoked per day. The effect of multifactorial risk assessment and screening for risk factors on oral cancer morbidity and mortality is unknown.. ...

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents ...

Results There was high expression of pp120 in 35 of 68 (51.5%) of general potentially malignant oral lesions and 23 of 30 (76.7%) of OSCCs compared with expression in normal oral mucosa. Kaplan-Meier analysis revealed that patients with potentially malignant oral lesions expressing high levels of membranous pp120 had a significantly higher incidence of OSCC than those expressing low expressing pp120 (p=0.002; log-rank test). Cox regression analysis revealed that this pp120 expression pattern was significantly associated with a 3.43-fold increase in the risk of malignant progression (p=0.007). In addition, there was a significant correlation between high levels of membranous expression of pp120 in pre-malignant lesions and cytoplasmic expression in post-malignant lesions (p=0.028). ...

SHPageId:1474,BodyPart:,BodyPartLst:[],Institution:null,SHDoctorConditionsTreatments:#Salivary Gland Tumours#, #Skin Cancer#, #Oropharyngeal Cancers#, #Hypopharyngeal Cancers#, #Nasopharyngeal Cancer#, #Parathyroid Surgery#, #Oral Cavity Cancers#, #Nasal cavity cancer#, #Thyroid Nodules and Cancers#, #Laryngeal Cancer#,SHDoctorConditionsTreatmentsLst:[salivary gland tumours,skin cancer,oropharyngeal cancers,hypopharyngeal cancers,nasopharyngeal cancer,parathyroid surgery,oral cavity cancers,nasal cavity cancer,thyroid nodules and cancers,laryngeal ...

Aim: Squamous cell carcinoma is the most common malignancy affecting the oral cavity. In spite of advanced therapeutic interventions, it is still a common cause of morbidity and mortality worldwide. The clinical presentation and prognosis of the carcinomas occurring at different sites in the oral cavity is varied and could be explained by the difference in the type of epithelia from which they originate. Therefore this study aimed to assess the patient and tumor characteristics, clinical presentation and behavior of a sample of oral squamous cell carcinomas (OSCC) to determine the parameters most likely to influence the prognosis based on the origin of the epithelium. Materials and methods: Eighty-nine cases of histologicallyproven oral squamous cell carcinoma with a minimum followup of three years were categorized based on their epithelia of origin. The clinical follow-up data and survival were collected from the patients records. New malignancy grading by Anneroth et al. was utilized for ...

During a comprehensive dental examination, our team will look for signs of oral cancer. Early detection is key with oral cancer. If caught early, most forms of oral cancer are treatable. Our dental team is trained and educated to identify oral cancer.. Everyone is susceptible to the disease, but some groups of people are at a higher risk level than others. Here are the top seven risk factors for oral cancer.. Age. Are you in your mid 40s? Your risk of developing oral cancer increases with age. A noticeable increase is evident in people in their 40s and older. According to the Cancer Treatment Centers of America, the majority of diagnosed cases occur around the age of 62, but the average age is declining. The recent increase in Human Papillomavirus (HPV) related cases is causing more people to be diagnosed for oral cancers between the ages of 52 and 56. As the average age for oral cancer cases decreases, it is vital that you receive regular oral cancer screenings at any age.. Gender. Men are ...

Liver X receptors (LXRs) participate not only in maintaining cholesterol homeostasis but also in controlling cellular growth in many types of normal and tumor cells. We previously reported that LXRα was aberrantly expressed in human oral squamous cell carcinoma (HOSCC) tissues and cell lines, and that LXR stimulation led to significant reduction of proliferation of HOSCC cells via accelerating cholesterol efflux. Since LXRs and downstream proteins involved in cholesterol metabolism could be also applied as therapeutic targets in small cell lung carcinoma (SCLC) and pancreatic ductal adenocarcinoma (PDAC), we herein analyzed the distribution of LXR proteins in these refractory cancers as well as in normal human lung and pancreatic tissues. LXRβ was observed in ciliated epithelial cells, bronchial gland epithelia, type II alveolar epithelia and alveolar macrophages of the lung, and was less expressed in bronchial basal cells and type I alveolar epithelia. In addition, LXRβ was detected in ...

The posters accepted for presentation were titled MICROBIAL DYSBIOSIS IN ORAL SQUAMOUS CELL CARCINOMA: A META ANALYSIS by RA A. Salam and NEXT GENERATION SEQUENCING (NGS) OF BRCA1 AND 2 GENES OF PAKISTANI WOMEN WITH FAMILIAL BREAST CANCER by RA O.K Afridi.. Oral Squamous Cell Carcinoma (OSCC) accounts for an estimated 354,864 new cases resulting into 177,384 deaths annually and has less than a 50% of 5-year survival rate in most regions of the world. Several risks factor such as tobacco, alcohol consumption, periodontitis (poor oral hygiene), viral infection (Human Papilloma Virus; HPV), poor nutrition, solar radiations, and genetic predisposition links have been reported to cause OSCC development. However, the number of OSCC cases are growing in which the above-mentioned risk factors may or may not be associated but has been rather linked with microbial dysbiosis.. Previous studies show that in 1990s, the relationship between bacterial flora and gastric cancer led scientists across the ...