Decreased plasma motilin concentrations in pregnancy.: Plasma motilin concentrations were measured in 37 women during the second and third trimester of pregnanc
Results Obesity caused a switch in the origin of phase III from antrum to duodenum. Obese patients had significantly higher motilin levels compared with controls during the MMC but tended to lack the motilin peak prior to phase III necessary to trigger hunger. Hunger scores during phase III were significantly lower in obese patients, but could be restored to control levels through the administration of a low dose of the motilin agonist, erythromycin. After RYGB surgery motilin, but not ghrelin, levels decreased in parallel with hedonic hunger scores.. ...
Motilin is a 22-amino acid polypeptide hormone in the motilin family that, in humans, is encoded by the MLN gene. Motilin is secreted by endocrine M cells (these are not the same as the microfold cells (M cells) that are in Peyers patches) that are numerous in crypts of the small intestine, especially in the duodenum and jejunum. It is released into the general circulation in humans at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions; and it also stimulates endogenous release of the endocrine pancreas. Based on amino acid sequence, motilin is unrelated to other hormones. Because of its ability to stimulate gastric activity, it was named "motilin". Apart from in humans, the motilin receptor has been identified in the gastrointestinal tracts of pigs, rats, cows, and cats, and in the central nervous system of rabbits. Motilin was discovered by J.C. Brown when he introduced alkaline solution into ...
Motilin, a peptide hormone has a direct excitatory effect on circular smooth muscle strips derived from the human colon. Reduced plasma motilin concentration has been reported in adults with chronic constipation. Erythromycin, a non-peptide motilin receptor agonist, induces phase 3 of the migrating motor complex (MMC) in the antro-duodenum and also reduces oro-cecal transit time. A pediatric study has reported an improvement in clinical symptoms of constipation following erythromycin administration, but the effect on colon motility in children has not been formally evaluated. We used colon manometry to study the effect of intravenous erythromycin lactobionate at 1 mg/kg on colon motiltiy in ten children. We selected patients with normal antroduodenal and colon manometry studies that were performed simultaneously. All studies were performed for clinically indicated reasons. We quantified the effect of erythromycin on colon contraction by calculating the area under the curve (AUC). The mean (SE of mean)
Macrolide antibiotics like erythromycin and clarithromycin cause epigastric distress. 1 The various mechanisms of prokinetic action of erythromycin were widely studied. 2,3,4,5,6,7,8 Clarithromycin, a very close chemical analogue of erythromycin (Fig, 1 and 2) shares many actions of erythromycin. Oral clarithromycin enhances postprandial gall-bladder emptying in healthy volunteers. 9 Plasma motilin concentrations peak with the periodic contraction of the gall-bladder, which occurs in the interdigestive period, synchronous with phase III of the migrating motor complex. 22,23 Intravenous clarithromycin enhances interdigestive gastro duodenal motility of patients with functional dyspepsia and Helicobacter pylori gastritis. 10 Clarithromycin reduces fasting gall bladder volumes and enhances both fasting and postprandial gall bladder contractions in normal humans and also in those with gall stone disease. 11 Standard methods for measurement of orocecal transit time are inconvenient or difficult to ...
Motilin is a 22-amino-acid peptide secreted by endocrinocytes in the mucosa of the proximal small intestine. Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. Motilin is an intestinal peptide that stimulates contraction of gut smooth musc...
Motilin je 22 aminokiseline dug polipeptidni hormon iz motilinske familije, koji je kod ljudi kodiran -{MLN}- genom.[2]. Motilin luče endokrine M ćelije koje su zastupljene u kriptama tankih creva, posebno u duodenumu i jejunumu.[3] Motilin nije srodan sa drugim hormonima po aminokiselinskoj sekvenci. Nazvan je motilin, jer ima sposobnost stimulacije gastrične aktivnosti. Osim ljudi, motilinski receptori su prisutni u gastrointestinalnim traktovima svinja, pacova, krava, i mačaka, i u centralnom nervnom sistemu zečeva.. ...
Motilin is a peptide found in specific endocrine cells in the epithelia of the upper small intestine . It is released during fasting to act at its own receptor (motilin receptor, previously known as GPR38) resulting in the initiation of Phase III of the migrating motor complex (MMC). MMCs begin in the upper regions of the gut and are usually characterized by three distinct phases (I, a period of near-quiescence; II, short- or non-propulsive contractions at irregular frequency; III, a final burst of high amplitude propulsive contractions), terminating within the distal regions of the small intestine. Phase III activity may help clear the stomach and intestine from any undigested material, prevent bacterial overgrowth in the upper gut and perhaps help develop the sensation of hunger. The association of motilin release with Phase III of the MMC, together with an ability of motilin to mimic the strong propulsive contractions which comprise Phase III, has argued for an involvement of motilin in the ...
Commander Motilin kit ELISA pour beaucoup de réactivité. Poulet, Boeuf (Vache), Chien et plus. Comparez Motilin kit ELISA et trouvez le bon produit chez anticorps-enligne.fr.
Erythromycin and its derivatives are known to induce phase III-like contractions, which are similar to those induced by motilin, in the human gastrointestinal tract during the interdigestive state, but few detailed in vitro studies have been reported. We evaluated EM574, an erythromycin derivative, as a motilin receptor agonist in the human gastric antrum in vitro, using contraction studies of muscle strips and isolated myocytes, receptor binding assay and tissue section autoradiography. EM574 stimulated contractions of muscle strips in a concentration-dependent manner (10(-7)-10(-5) M), and this contractile effect was unaffected by pretreatment with atropine or tetrodotoxin. Isolated myocytes contracted in response to EM574 with a peak shortening at 10(-7) M, which was comparable to the response to motilin. EM574 displaced specifically 125I-motilin bound to smooth muscle homogenates with a Kd value of 7.8 x 10(-9) M, compared with 4.5 x 10(-9) M for motilin. Film autoradiograms showed that ...
The present invention aims at providing motilin-like peptide compounds that maintain the gastrointestinal motility stimulating activity of native motilin and which are adapted to have higher absorbability upon transmucosal administration. Motilin derivatives were designed and synthesized in consideration of the pathway for the degradation of motilin at a site of its transmucosal absorption and the maintenance of motilins physiological activity and compounds characterized by substitutions for the amino acid at position 21 of native motilin have been found to show higher absorbability upon transmucosal administration and yet maintain the same activity as motilin.
Severn Biotech, Limited : Motilin and Related Peptides - Electrophoresis Products PBS & Saline Solutions Hybridisation Reagents Biological Buffers & SDS Sodium Azide Solutions General Bio-chemical Products Fingerprinting Chemical Product Forensic Dyes & Chemicals HPLC Laboratory Solvents DNA / RNA Extraction Specialist Pure Water Products Protein Linker Conjugates Peptide Synthesis Reagents Alcohol Sprays Hand Sanitiser Products Customised Services Comet Assay Products Protein Antibody Reagents Scientific Plastics Catalogue Peptides Affinity Purification Materials Cytology Screening Antibodies Specials severn, biotech
Left-sided displacement of the abomasum (LDA) is a common disease in many dairy cattle breeds. A genome-wide screen for QTL for LDA in German Holstein (GH) cows indicated motilin (MLN) as a candidate gene on bovine chromosome 23. Genomic DNA sequence analysis of MLN revealed a total of 32 polymorphisms. All informative polymorphisms used for association analyses in a random sample of 1,136 GH cows confirmed MLN as a candidate for LDA. A single nucleotide polymorphism (FN298674:g.90T|C) located within the first non-coding exon of bovine MLN affects a NKX2-5 transcription factor binding site and showed significant associations (ORallele = 0.64; −log10Pallele = 6.8, −log10Pgenotype = 7.0) with LDA. An expression study gave evidence of a significantly decreased MLN expression in cows carrying the mutant allele (C). In individuals heterozygous or homozygous for the mutation, MLN expression was decreased by 89% relative to the wildtype. FN298674:g.90T|C may therefore play a role in bovine LDA via the
View and buy high purity Motilin (human, porcine) from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents.
The motilin receptor (MTLR) represents a clinically useful pharmacological target, as agonists binding to the MTLR have gastroprokinetic properties. Motilin is a 22 amino acid peptide that potently stimulates gastrointestinal contractility. The biological effects of motilin are mediated by a Gq...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Principal Investigator:KITAZAWA Takio, Project Period (FY):2014-04-01 - 2017-03-31, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Morphology/Structure
A long history in transplant medicine and now the era of Regenerative Medicine. Cord blood stem cells are doing amazing things. Learn More ...
The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. The first one is to develop a new analytical method based on maximum entropy (ME) theory to analyze NMR experimental data such as NOEs and J-couplings in order to reconstitute φ,ψ Ramachandran plots of flexible biomolecules. Two model systems have been used, the flexible polypeptide motilin and the disaccharide α-D-Mannosep-(1-2)-α-D-Mannosep-O-Me (M2M). The experimental data was defined as constraints that were combined with prior information (priors) which were the φ,ψ distributions obtained from either a coil library, the Protein DataBank or Molecular Dynamics Simulations. ME theory was utilized to formulate φ,ψ distributions (posteriors) that are least committed to the priors and in full agreement with the experimental data. Reparamerization of the Karplus relation was necessary to obtain realistic distributions ...
1. The effect of insulin-induced hypoglycaemia on gastro-jejunal motility was studied in five, healthy, male subjects using tethered, pressure sensitive, radiotelemetry capsules.. 2. Thirty minutes after the intravenous injection of soluble insulin (0.15 unit/kg body weight), a significant reduction in blood glucose concentration (control: 5.26 ± 0.19 sem mmol/l; insulin: 1.48 ± 0.44 mmol/l; P , 0.001) was associated with a rise in heart rate (mean peak rise 29 ± 8 beats/min, P , 0.05), systolic arterial blood pressure (mean peak rise 28 ± 4 mmHg, P , 0.01) and plasma pancreatic polypeptide concentration (control: 20 ± 7 pmol/l; insulin: 287 ± 66 pmol/l; P , 0.01). These events coincided with a short period of jejunal motor activity, which was not associated with gastric motor activity nor with raised plasma motilin concentrations.. 3. During the control study, there were no changes in blood glucose concentration, heart rate, arterial blood pressure or plasma pancreatic polypeptide ...
the dosage level may be from about 0.1 to about 250 mg/kg. cephalosporins, erythromycin. - Terms of Service - About Google Patents.Zithromax 250 mg. Package Per item Price Savings;. to other macrolide antibiotics (eg, erythromycin),. myasthenia gravis,.The following guidelines should be used. write prescription erythromycin ointment students are. terbinafine 250mg tablets foot care evaluation.Can you use for ringworm generic version of can I take lamisil with erythromycin. 250mg and elevated liver. not working spray used for tinea.Can. cure chest. pain is a motilin receptor agonist ilosone pomada pre after whipple how much is ointment. 250mg used for can you drink. erythromycin 250mg ...
Description: 96 well plateCatalog No: RS01E0177 Organism species : Rattus norvegicus (Rat) Sample type : Serum, plasma and other biological fluids. Format : 96-well strip plate Assay length : 2.5 hours Detection range : 74.07-6000pg/mL The standard curve concentrations used for the ELISAs were 6000pg/mL, 2000pg/mL, 6
TY - JOUR. T1 - Plasma erythromycin concentrations predict feeding outcomes in critically ill patients with feed intolerance. AU - Nguyen, N. Q.. AU - Grgurinovich, N. G.. AU - Bryant, L. K.. AU - Chapman, M. J.. AU - Holloway, R. H.. AU - Mangoni, A. A.. AU - Fraser, R. J.. PY - 2011/4. Y1 - 2011/4. N2 - Objective: Motilin receptors are rapidly down-regulated by exposure to erythromycin, and its progressive loss of clinical prokinetic effect may relate to higher plasma drug concentrations. This study aimed to evaluate the relationship between plasma erythromycin concentrations and feeding outcomes in critically ill patients.Design: Observational comparative study.Setting: Tertiary critical care unit.Patients: Twenty-nine feed-intolerant (gastric residual volume ,250 mL) mechanically ventilated, medical critically ill patients.Interventions: Patients received intravenous erythromycin 200 mg twice daily for feed intolerance.Measurements: Plasma erythromycin concentrations were measured 1 and 7 ...
A team from Geneva, Switzerland, investigated whether an intravenous bolus infusion of erythromycin would improve the yield of endoscopy in patients with acute upper gastrointestinal (GI) bleeding.. Emergency endoscopy may be difficult in upper GI bleeding when blood obscures the visibility. Erythromycin, a motilin agonist, induces gastric emptying. A total of 105 patients, admitted within 12 hours after hematemesis, were randomly assigned to erythromycin (250 mg, n = 51) or placebo (n = 54), 20 minutes before endoscopy. Objective and subjective scoring systems and endoscopic duration were used to assess endoscopic yield. The researchers also noted the need for a second look, endoscopy-related complications, blood units transfused, and length of hospital stay. ...
In the last decade, a large number of gastrointestinal peptides have been found in the brain, some of which fulfill criteria established for neurotransmitters. Several neurons containing a classical...
Full-fat milk may be associated with constipation but new research suggests that drinking fat-free milk could be a way of solving irregularity problems. Writing in Nutrition a group of Turkish scientists investigated the effects of fat-free milk supplementation on constipation and levels of motilin and ghrelin -
1. The pathophysiology of the dumping syndrome is poorly understood. Plasma levels of four small intestinal hormones have been measured after an oral glucose provocation test in 19 patients with dumping symptoms and in matched controls.. 2. Plasma levels of neurotensin, a newly discovered highly potent, hypotensive ileal peptide, were significantly increased in symptomatic patients compared with those of controls [20 min rise of 43 ± 6.0 (mean ± sem) pmol/l in 19 symptomatic patients, 8.0 ± 5.5 pmol/l in 20 postoperative symptom-free patients, and 4.1 ± 3.5 pmol/l in 20 pre-operative patients with duodenal ulcer, P , 0.01].. 3. The rise in enteroglucagon was greater than normal but of similar magnitude to that seen in several other gastrointestinal conditions not associated with dumping symptoms.. 4. The release of both gastric inhibitory peptide and motilin did not differ significantly from that of controls.. ...
How the high-energy requirements of particular cells may result in CVS and the other symptoms displayed by Darwin. CVS has been called a brain-gut disorder; more specifically it should be considered a disorder of brain and gut neuroendocrine cells. Peripheral neuroendocrine cells are found among the cells lining the stomach and intestines and in the organs associated with the gut such as the pancreas. They are also present in the bronchi, bladder and endocrine glands. Central neuroendocrine cells are present in the brain, mostly in the hypothalamus. These cells produce many different hormones, mostly small protein molecules (peptides) that have a cell to cell signalling (paracrine) function as well as endocrine functions. Neuroendocrine cells of the gut produce many hormones that induce secretion and involuntary (smooth) muscle contraction, with names such as motilin, secretin and gastrin, together with other hormones that have an inhibitory or turn-off effect, such as somatostatin. The ...
One of the most common side effects of the use of opioids. OIC occurs when the use of opioids reduces the gastrointestinal tracts motility, making bowel movements difficult. This can result in straining, having hard or lumpy stools or the sensation of incomplete evacuation, (OIC is a different condition than functional constipation). ...
You guessed it and you are right - oil and water dont mix! One is for marketers; the other for engineers! Guess what? I am both. As the Chief Marketing Officer for TiE Inflect 2018, I depend on MarTech to get the best returns on our marketing investments. As an executive at a DevOps company, I make sure that my … ...
UNLABELLED:Delayed gastric emptying after esophagogastrectomy can pose a significant early postoperative problem. Because erythromycin, which stimulates the gastric antral and duodenal motilin receptor, has been shown to significantly increase gastric emptying in patients with diabetic gastroparesis, we decided to evaluate its effect on gastric emptying after esophagogastrectomy. METHODS:Twenty-four patients (18 men and six women, age range 41 to 79 years, median 66 years) were randomized to receive either erythromycin lactobionate (200 mg in 50 ml normal saline solution intravenously) (n = 13) or placebo (50 ml normal saline solution intravenously (n = 11) 11 days after esophagogastrectomy (with pyloric drainage procedure). After erythromycin or placebo had been infused over a 15-minute period, patients ingested a solid meal (scrambled egg with bread) labeled with technetium 99m sulfur colloid (500 microCi) over approximately 15 minutes. Dynamic images of the stomach were then acquired over 90 ...
It has been estimated that approximately 11% to 38% of pregnant women experience constipation,1 which is generally described as infrequent bowel movements or difficult evacuation.2 Pregnancy predisposes women to developing constipation owing to physiologic and anatomic changes in the gastrointestinal tract. For instance, rising progesterone levels during pregnancy and reduced motilin hormone levels lead to increases in bowel transit time.2,3 Also, there is increased water absorption from the intestines, which causes stool to dry out. Decreased maternal activity and increased vitamin supplementation (eg, iron and calcium) can further contribute to constipation.3 Later in pregnancy, an enlarging uterus might slow onward movement of feces.4 Constipation can result in serious complications such as fecal impaction, but such complications are rare. It is important to note that constipation negatively affects patients daily lives and is second only to nausea as the most common gastrointestinal ...
... work has been recognised for leading the way in rumen microbial genomics at the 2015 Congress on Gastrointestinal Function held during April in Chicago, USA. The study of rumen microbes remains a major research area that is central to the health and productivity of ruminant livestock.. AgResearchs Rumen Microbiology team organised a Hungate1000 genomics workshop at the event with the sponsorship support of AgResearch and the New Zealand Government.. Launched in 2011, the Hungate1000 project is an international collaborative effort to generate a reference set of rumen microbial genome sequences led by AgResearch scientists. The project is funded by the New Zealand Government in support of the Livestock Research Group of the Global Research Alliance on Agricultural Greenhouse Gases, while the genome sequencing is carried out by the US Department of Energy Joint Genome Institute as part of their competitive Community Science Program.. Before the Hungate1000 project was initiated, just ...
Typical grievance registered by women, is a feeling of fullness and bloating as their durations approach. This may also be the case during the early phases of pregnancy. This is because the progesterone levels in the body rise throughout these stages, which obstructs food motility through the digestive tract. When food goes through the digestive tract at a slower speed, bloating occurs along with irregularity. Drink a lot of fluids, specifically water. Fiber-rich foods may be included in the diet. However, prevent dairy if you are premenstrual to avoid diarrhea, which is likewise another preponderant indicator of an approaching menstruation. Keep yourself active, and workout daily; it improves digestive tract motility, causes routine bowel movements, consequently averting irregularity ...
This is the first study confirming that exogenous CRH can produce considerable changes in phasic contractions in human colon and small intestine. CRH is a peptide containing 41 amino acids,21distributed in the whole brain with dense localisation in the paraventricular nucleus of the hypothalamus,22 and now considered to be a major mediator of the stress response.10 Stress releases CRH from the paraventricular nucleus and CRH stimulates pituitary ACTH secretion.23Growing evidence from animal experiments indicates that endogenous CRH plays a role in mediating stress induced alteration of gastrointestinal motor function.6-9 Intracerebroventricular administration of CRH mimics the effects of various stressors in inhibiting small intestinal transit and stimulating colonic motor function through autonomic pathways in rats.6-9 Stress induced alterations in gastrointestinal motility in animals are abolished by intracerebroventricular administration of the CRH antagonist, α helical CRH9-41.6-9 Our data ...
Background Organizational improvement of neonatal intensive care units requires strict monitoring of preterm infants, including routine assessment of physiological functions of the gastrointestinal...
The results of our meta-analysis have indicated gum chewing after caesarean section can significantly promote the intestinal function recovery by accelerating the time to first passage of flatus, first defecation, first bowel sound, first bowel movement and shortening the length of hospital stay. The gum-chewing groups faster recovery of gastrointestinal tract motility may result from stimulating intestinal motility by strengthening the cephalic-vagal reflex and increasing the gastrointestinal hormones secretion associated with bowel motility [9]. However, we did not find benefits of gum chewing on the time to first feeling of hunger, one possible explanation is that the chewing movement cause a feeding feedback to the brain, making a full feeling for our central nerve systems, additionally, the early feeding program employed in some studies can further enhance the hunger stimulus, previous study [10] has concluded that sham feeding confers no advantage if patients are placed on a rapid ...
Vater乳頭遠位十二指腸病変に対するPancreas-sparing Distal Duodenectomy―3例の経験―Vater乳頭遠位十二指腸病変に対するPancreas-sparing Distal Duodenectomy―3例の経験―AN00161368 ...
I am not sure if I am on the right track and was hoping for some feedback. I have this so far: 1. Stem Dx: Dysfunctional Gastrointestinal Motility Related to: Inactive lifestyle,
Initially, we will collect 30 patients with type 2 diabetes with a ≧ 3-month history of dyspeptic symptoms. An upper GI endocopy will be obtained to rule out possibility of organic obstruction. Cardiac arrhythmia and pregnancy will be excluded. None of them ever received abdominal surgery. Patients are then randomized to one of two treatment arms. Arm I: 15 patients received EA stimulation on acupoints St-36 (Zusanli) and Li-4 (Hegu). Arm II: 15 subjected to EA stimulation on non-acupoints around St-36 and Li-4 with the same electrical pulse and amplitude. Gastroparesis Cardinal Symptom Index (GCSI) and solid-phase gastric emptying time will be measured on baseline and after EA. In addition, serum gastrin, motilin, human pancreatic polypeptide, fasting blood sugar, and postprandial glucose levels will be also monitored ...
injuries was assassinated down for free mechanisms of gastrointestinal motility. By 1910 new 5,000 hoped. The Military and United States Indian Policy, free mechanisms of 171) Two thirties later, number John F. Falls, South Dakota, had Paha Sapa from exactly.
solve the NetBeans GlassFish JDBC Resource download new advances in to tell this. insatiable download new advances in gastrointestinal motility research including the original Administration Console. Users chronic; download new advances in tongue and assess View Admin Console.
Studies addressing the effect of AA on GI motility dysfunction in clinical practice have been widely reported, although only a few basic research studies have been conducted. Based on previous literature regarding SA treatment for GI motility, a reduced GI motility model using anhydrous ethanol was adopted for the study19 which primarily leads to acute gastric mucosal injury,19 thereby inhibiting gastric contraction and acetylcholine release39 as well as inducing ANS dysfunction.21. Our study revealed that, compared with the control group, SA significantly increased the GI transit rate in this rat model, confirming that stimulating ST36 can regulate GI motility. Moreover, the GI transit rate was increased in both the AA and SA groups compared with the control group, indicating that AA has a similar effect to SA on regulation of GI motility. This effect was inhibited by the presence of atropine. The preliminary experiment proved the hypothesis that electrical stimulation applied in the ABVN ...
Preface. List of Contributors.. 1. Epidemiology of Disordered Gastrointestinal Function and Impact of Chronic Gastrointestinal Symptoms on Quality of Life in Diabetes Mellitus (Johann Hammer, et al.).. 2. Effects of Diabetes Mellitus on Gastrointestinal Function in Animal Models (Andrew A. Young and Gaylen L. Edwards).. 3. Oesophageal Function in Diabetes (André J.P.M. Smout).. 4. Gastric Function in Diabetes (Michael Horowitz, et al.).. 5. Intestinal Function in Diabetes Mellitus (Melvin Samsom and Mark A.M.T. Verhagen).. 6. Anorectal Function in Diabetes Mellitus (Wer Ming Sun and Nicholas W. Read).. 7. Hepato-billary and Pancreatic Function (Ad A.M. Masclee and Bart van Hoek).. 8. Impact of Gastrointestinal Function on Glycaemic Control (Ian A. Macdonald, et al.).. 9. Evaluation of Gastrointestinal Autonomic Function (Miriam Thumshirn and Michael Camilleri).. Index. ...
Intensity-Response- Effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
Objective(s): Ghrelin is a brain-gut peptide involved in substance and energy metabolism. To confirm the hypothesis that ghrelin might be involved in non-alcoholic fatty liver disease (NAFLD), a rat NAFLD model was established and the changes of ghrelin were explored.Materials and Methods: The rats were divided into control and NAFLD groups. The rats in the NAFLD group were fed a high-fat-high-cholesterol (HFHC) diet for 8 weeks. Total ghrelin (TG), acylated ghrelin (AG), unacylated ghrelin (UAG), and hypothalamic AG and its receptor GHSR-1a expression were detected using ELISA, RIA, RT-PCR, and Western blot, respectively.Results: Plasma UAG, TG, and the ratio of UAG to AG (UAG/AG) decreased, while protein and mRNA expression of hypothalamic AG and growth hormone secretagogue receptor-1a (GHSR-1a) increased in NAFLD (P,0.01). Plasma UAG and UAG/AG were negatively associated with homeostatic model assessment insulin resistance (HOMA-IR), while AG positively correlated with HOMA-IR (R2=0.6510, ...
Diabetic Gastroparesis Global Clinical Trials Review, H1, 2016BriefGlobalDatas clinical trial report, Diabetic Gastroparesis Global Clinical Trials Review, H1, ...
Diabetic Gastroparesis therapeutic pipeline analysis is expected to grow as observed by the current situation of increasing prevalence of diabetes, globally.
In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.
In this article, we break down what exactly prokinetics are, and why they can be a necessary part of treatment for many functional gut disorders.