Studies of experimental infection of prairie dogs (Cynomys ludovicianus) with monkeypox virus are described. After intraperitoneal infection, all of the animals died within 11 days. Virus was cultured from their blood and oropharynx several days before death; at necropsy, most of the organs tested contained monkeypox virus. Marked hepatic and splenic necrosis were observed, along with mild inflammatory changes in the lungs. After intranasal infection, the primary pathologic changes were in the lungs and pleural cavity. Some of the intranasally infected animals (40%) survived, and monkeypox virus could be cultured from their nasal discharge and oropharynx for <22 days. Ulcerative lesions also developed on the lips, tongue, and buccal mucosa of the surviving animals. Our findings support an earlier report, which suggested that infected prairie dogs can transmit monkeypox virus by respiratory and mucocutaneous contact with susceptible animals and persons.
Monkeypox is an orthopoxvirus with enzootic circulation in rainforests of central and western Africa; the virus can be transmitted to humans and cause a syndrome clinically similar to smallpox (e.g., pustular rash, fever, respiratory symptoms, and in some cases, death). From February through August 1996, a total of 71 clinical cases of monkeypox, including six deaths, occurred in 13 villages in Africa in the Katako-Kombe health zone (1996 combined population: 15,698), Sankuru subregion, Kasai Oriental, Zaire (Figure_1) (1). During the initial investigation of this cluster of human cases, specimens of serum and/or crusted scab or fluid from vesicles were collected from 11 patients, and monkeypox virus infection was confirmed in all 11 patients by the World Health Organization (WHO) Collaborating Center for Smallpox and Other Poxvirus Infections at CDC. Preliminary DNA phylogenetic studies of this strain of virus indicated only minor genetic variation compared with other strains of monkeypox virus ...
This chapter focuses on epidemiologic, ecologic, and biologic observations made since the publication of Emerging Infections 4 which enhance the understanding of Human monkeypox, zoonotic disease and the pathogen that causes it. Ecologic studies, usually using convenient samples of animals collected in areas surrounding human patients in West Africa and central Africa, demonstrated orthopoxvirus- and sometimes monkeypox virus-specific seroprevalence in various members of these species, but it was not reported for Cricetomys species. In 2003, two concurrent outbreaks of disease, one in the United States and one in the Republic of the Congo, permitted additional analyses and studies which have substantially amplified the understanding of monkeypox viruses and their pathogeneses in various animal species, which in turn will allow the design of public health control measures. Gambian rats (Cricetomys sp.) and rope squirrels (Funisciurus spp.) separated from the shipment immediately on arrival in the United
RICHLAND, Wash. - A new study of an exotic, infectious virus that has caused three recent outbreaks in the United States reveals clues to how the virus might damage lungs during infection. The findings also suggest possible new ways to treat lung diseases in humans.. Not only does the infection from monkeypox virus increase production of proteins involved in inflammation, but it decreases production of proteins that keep lung tissue intact and lubricated. The findings appear in an upcoming issue of Molecular & Cellular Proteomics.. "Going into this study, we thought monkeypox caused disease primarily by inducing inflammation in the lung, and that leads to pneumonia," said lead author Joseph Brown, a systems biologist at the Department of Energys Pacific Northwest National Laboratory. "We were surprised to see how badly the virus wrecked the structural integrity of the lungs.". The study was funded by the National Institute of Allergy and Infectious Diseases and the National Center for Research ...
Monkeypox is a rare viral disease. It occurs mostly in central and western Africa. Learn about how it spreads and what the symptoms are.
Free Public Domain Picture: Here a negative stain electron micrograph reveals a M (mulberry type) monkeypox virus virion in human vesicular fluid. See PHIL 10817 for | ID: 13540024213919
Abstract. An increased incidence of monkeypox (MPX) infections in the Democratic Republic of the Congo was noted by the regional surveillance system in October 2013. Little information exists regarding how MPX is introduced into the community and the factors associated with transmission within the household. Sixty-eight wild animals were collected and tested for Orthopoxvirus. Two of three rope squirrels (Funisciurus sp.) were positive for antibodies to Orthopoxviruses; however, no increased risk was associated with the consumption or preparation of rope squirrels. A retrospective cohort investigation and a case-control investigation were performed to identify risk factors affecting the introduction of monkeypox virus (MPXV) into the community and transmission within the home. School-age males were the individuals most frequently identified as the first person infected in the household and were the group most frequently affected overall. Risk factors of acquiring MPXV in a household included sleeping in
monkeypox virus can be transmitted when a person comes into contact with the virus from an animal, human, or materials contaminated with the virus.. The virus enters the body through broken skin (even if not visible), respiratory tract, or the mucous membranes (eyes, nose, or mouth). Animal-to-human transmission may occur by bite or scratch, bush meat preparation, direct contact with body fluids or lesion material, or indirect contact with lesion material, such as through contaminated bedding.. Human-to-human transmission is thought to occur primarily through large respiratory droplets. Respiratory droplets generally cannot travel more than a few feet, so prolonged face-to-face contact is required.. Other human-to-human methods of transmission include direct contact with body fluids or lesion material, and indirect contact with lesion material, such as through contaminated clothing or linens.. Symptoms. In humans, the symptoms of monkeypox are similar to but milder than the symptoms of smallpox. ...
monkeypox: Viral disease of both animals and humans that causes symptoms similar to those of smallpox, though less severe. It is transmitted by the monkeypox virus, a member of the same virus...
You may have heard of chickenpox, but do you know about monkeypox? It may have a funny name, but the monkeypox virus is not a laughing matter.
CDC has received reports of patients with a febrile rash illness who had close contact with pet prairie dogs and other animals. The Marshfield Clinic, Marshfield, Wisconsin, identified a virus morphologically consistent with a poxvirus by electron microscopy of skin lesion tissue from a patient, lymph node tissue from the patients pet prairie dog, and isolates of virus from culture of these tissues. Additional laboratory testing at CDC indicated that the causative agent is a monkeypox virus, a member of the orthopoxvirus group. This report summarizes initial descriptive epidemiologic, clinical, and laboratory data, interim infection-control guidance, and new animal import regulations. As of June 10, a total of 53 cases had been investigated in Illinois, Indiana, and Wisconsin. Of these, 29 (49%) cases were among males; the median age was 26 years (range: 4--53 years). Data were unavailable for sex and age for two and 14 patients, respectively. A total of 14 (26%) patients have been ...
When dozens of people in Americas heartland came down with the African monkeypox virus, medical researchers were stumped. Join them on a hunt for the source of the exotic virus.
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Monkeypox is a relatively rare disease that was first detected in monkeys in Africa in 1958 and resembles smallpox in terms of the skin lesions (pox) seen in humans as part of the physical findings and also because the cause is a virus that is closely related to the smallpox (variola) virus. Monkeypox, smallpox, cowpox, and vaccinia viruses all belong to the same family of viruses, the Poxviridae. Monkeypox belongs to same genus (Orthopoxvirus) as smallpox. The disease is different from smallpox. Monkeypox may be transferred from animals to people (or person to person) and has far less mortality (death rate) than smallpox had. Monkeypox virus is endemic in rodent populations in Africa. Smallpox did not infect any endemic animal population. The press and bloggers have occasionally tried to link monkeypox to other diseases such as mad cow disease, Ebola, leprosy, yellow fever, and other viral and immunological diseases, but there is no scientific evidence.. What is the history of ...
Monkeypox is a relatively rare disease that was first detected in monkeys in Africa in 1958 and resembles smallpox in terms of the skin lesions (pox) seen in humans as part of the physical findings and also because the cause is a virus that is closely related to the smallpox (variola) virus. Monkeypox, smallpox, cowpox, and vaccinia viruses all belong to the same family of viruses, the Poxviridae. Monkeypox belongs to same genus (Orthopoxvirus) as smallpox. The disease is different from smallpox. Monkeypox may be transferred from animals to people (or person to person) and has far less mortality (death rate) than smallpox had. Monkeypox virus is endemic in rodent populations in Africa. Smallpox did not infect any endemic animal population. The press and bloggers have occasionally tried to link monkeypox to other diseases such as mad cow disease, Ebola, leprosy, yellow fever, and other viral and immunological diseases, but there is no scientific evidence.. What is the history of ...
We determined factors associated with occupational transmission in Wisconsin during the 2003 outbreak of prairie dog-associated monkeypox virus infections. Our investigation included active contact surveillance, exposure-related interviews, and a veterinary facility cohort study. We identified 19 confirmed, 5 probable, and 3 suspected cases. Rash, headache, sweats, and fever were reported by &gt;80% of patients. Occupationally transmitted infections occurred in 12 veterinary staff, 2 pet store employees, and 2 animal distributors. The following were associated with illness: working directly with animal care (p = 0.002), being involved in prairie dog examination, caring for an animal within 6 feet of an ill prairie dog (p = 0.03), feeding an ill prairie dog (p = 0.002), and using an antihistamine (p = 0.04). Having never handled an ill prairie dog (p = 0.004) was protective. Veterinary staff used personal protective equipment sporadically. Our findings underscore the importance of standard veterinary
Monkeypox, a cousin of smallpox that normally dwells in the rainforests of Western and Central Africa, has popped up in towns in three states in the U.S. Midwest, infecting pet prairie dogs and their owners. It is the first time that a monkeypox outbreak has been seen in the Western Hemisphere. ...
Monkeypox challenge.Based on the dosing experiments (Fig. 2a), a dose of 2 × 107 PFU was chosen for the vaccine evaluation experiment. Vaccinated monkeys were challenged with MPOV-Z79 by i.v. injection into the right or left saphenous vein. At 2-day intervals, whole-blood, serum, and throat swab samples were collected, and rectal temperature, pulse, and blood oxygen saturation were measured. Salient clinical and laboratory findings are shown in Table 1 and Fig. 2b (also see Fig. 4). Monkeys vaccinated with the negative control DNA vaccine developed grave monkeypox and succumbed on days 7, 10, and 14. Monkeys vaccinated with Dryvax showed no signs of clinical disease, indicating that VACV given more than a year earlier could confer protective immunity against this robust MPOV challenge dose. This confirms earlier findings that vaccination of rhesus macaques with a commercial smallpox vaccine confers protection against monkeypox after i.v. challenge (22). Monkeys vaccinated with the L1R DNA ...
The Bayelsa State government says some persons in the state infected with the deadly Monkeypox virus have started showing signs of recovery. Twelve persons were quarantined in the state after the first case of suspected monkeypox infection was reported a few days ago. The virus later spread to the neighbouring state of Rivers. The Commissioner for Information in Bayelsa, Daniel Iworiso-Markson, in a statement issued on Sunday, said that the infected persons who were quarantined at the Niger Delta University Teaching Hospital, NDUTH, Okolobiri, were showing signs of recovery. Mr. Iworiso-Markson didnt provide details on the recovery, but said that
With Monkey Pox outbreak in Bayelsa, the Minister of Health, Prof. Adewole warns Nigerians to avoid consuming bush meat and rodents.. it has become imperative to sensitize the public about the infectious disease called monkeypox with monkeypox in Bayelsa and the minister of health warning Nigerians to avoid consuming bush meats and rodents.. it has become imperative to sensitize the public about the infectious disease called monkeypox Monkeypox is a rare viral zoonosis (a virus transmitted to humans from animals) with symptoms in humans similar to those seen in the past in smallpox patients, although less severe.. Smallpox was eradicated in 1980.However, monkeypox still occurs sporadically in some parts of Africa.. Transmission of Monkeypox Transmission of monkeypox virus occurs when a person comes into contact with the virus from an animal, human, or materials contaminated with the virus.. The virus enters the body through broken skin (even if not visible), respiratory tract, or the mucous ...
Important Note and Disclaimer: The contents of this Ezine have not been evaluated by the Food and Drug Administration. Information conveyed herein is from sources deemed to be accurate and reliable, but no guarantee can be made in regards to the accuracy and reliability thereof. The author, Steve Barwick, is a natural health journalist with over 30 years of experience writing professionally about natural health topics. He is not a doctor. Therefore, nothing stated in this Ezine should be construed as prescriptive in nature, nor is any part of this Ezine meant to be considered a substitute for professional medical advice. Nothing reported herein is intended to diagnose, treat, cure or prevent any disease. The author is simply reporting in journalistic fashion what he has learned during the past 17 years of journalistic research into colloidal silver and its usage. Therefore, the information and data presented should be considered for informational purposes only, and approached with caution. ...
These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.
He said, "We want to rule it out categorically. We are not vaccinating anywhere. Absolutely not! There is one vaccination exercise starting tomorrow (Friday) in Kwara on yellow fever in 18 local government areas and there are vaccination campaigns for other issues.. "No monkeypox vaccination. Do not participate in any of such. There are other vaccinations, which are being delivered to prevent diseases in our children but nothing like monkeypox vaccination.. "As far as I know, there is no agency of the Federal Government that is doing this - civilian or military. I have enquired; we have worked very closely with the Medical Corps of the Nigerian military.. "I met with them yesterday (Wednesday) and I have been assured that nothing like that is going on anywhere in the country. A lot of these (reports) are rumours being spread for malicious reasons.". Ihekwazu also explained that contrary to the belief that the disease was peculiar to monkeys, the virus could be contracted from rodents.. "The ...
The program helps to characterize environmental and epidemiologic aspects of human monkeypox and to assess clinical intervention strategies.
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... is a disease caused by a germ (virus) and is similar to camelpox, smallpox and cowpox. This is the forum for discussing anything related to this health condition
At its plenary in Abuja, presided over by the Speaker, Mr. Yakubu Dogara, the House was alarmed that the disease was spreading while it appeared that the Federal Ministry of Health was helpless without relying on the World Health Organisation.. A lawmaker from Bayelsa State, Mr. Diri Douye, raised the issue under matters of urgent national importance, praying that the minister should be summoned.. The prayer was immediately passed in a unanimous voice vote.. Lawmakers expressed concern that a country, as big as Nigeria, did not have a laboratory to respond to the health emergency without first sending specimen to Dakar, Senegal, for investigations.. They were also in shock that Adewole admitted that Nigeria was helpless.. "The House is concerned by the shocking admission of Adewole that monkeypox could not be confirmed in Nigeria until laboratory investigations by WHO and referral to Dakar, Senegal.. "Again, concerned that the disease has spread to other states, notably Uyo in Akwa Ibom State, ...
The Federal Government has described as fake and sinister the report that the outbreak of monkeypox in some parts of the country resulted from the alleged free medical care by the government in the affected areas. In a statement issued in Abuja on Sunday, the Minister of Information and Culture, Lai...The Advocate
The Council also received an update on the state of the public health of the nation. We informed the council about the latest development in respect of the Monkey Pox virus outbreak. So far as of today, there are 74 suspected cases in 11 states of the country ...
We are still expecting the results of the other ones. We are also doing tests at the African Centre of Excellence for Genomics of Infectious Diseases, Ede, to really understand the genomics of this virus. Even when they are negative, the laboratory attendant should be able to tell us what exactly they are. ...
Worst hate crime: Former Albemarle deputy Stephen Shifletts March 13 alleged allegation. If he really concocted a fake shooting by an imaginary African American, he may join South Carolinian child-drowner Susan Smith and late Bostonian wife-killer Charles Stuart in the pantheon of race-baiting criminals. Best thing about the fake shooting: Nobody got shot.. Worst MIA at RWSA/RSWA: Rivanna Water and Sewer Authority and Rivanna Solid Waste Authority executive director Larry Tropea disappears, taking a mysterious administrative leave with pay before resigning June 9, David Dadurka reports in the Daily Progress.. Worst outbreak: The African monkeypox virus, previously unseen in the Western Hemisphere, hits the Midwest through infected pet prairie dogs.. Worst return disease in Virginia: West Nile, which is spread by mosquitoes, turns up in two Fauquier County crows.. Worst intestinal outbreak: The Hyatt Dulles is closed and scrubbed down after 60 wedding guests are stricken with a virus similar to ...
a systematic review of data published between 1965 and 2013. Lancet 386, 1546-1555.. Yinka-Ogunleye, A., Aruna, O., Dalhat, M., …, Tom-Aba, D., Silenou, B., …, Krause, G., Ihekweazu, C. (2019). Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. The Lancet Infectious diseases 19, 872-879.. Ott, J.J., Horn, J., Krause, G., and Mikolajczyk, R.T. (2017). Time trends of chronic HBV ...
HealthFolk is focused on collaboration for healthcare innovation in Nigeria. ... Public Health England (PHE) has said. The patient is believed to have contracted the infection while visiting Nigeria and is currently being treated at ...
The National Park Service (NPS) is preparing an Environmental Assessment (EA) and Biological Assessment (BA) for a Utah Prairie Dog Stewardship Plan. Utah prairie dogs (Cynomys parvidens) are a federally-threatened species listed by the U.S. Fish and Wildlife Service and are protected under the Endangered Species Act (ESA). Among the purposes of the proposed stewardship plan would be to: ″Maintain a sustainable population of Utah prairie dogs to foster their role as a keystone species in the environment.″ Identify ways to enhance prairie dog habitat within the park based on habitat suitability and connectivity with existing populations, while maintaining the diversity of native plant communities and facilitating park operations. ″Minimize/mitigate the effects of human activities in the park on Utah prairie dogs.″ Contribute to range-wide recovery and sustainability of Utah prairie dog populations. Once completed, this plan will be used to benefit the management of Utah prairie dogs, ...
The World Health Organization issued recommendations for naming infectious diseases, concerned about stigmas of names like swine flu and monkeypox.
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According to the Ministry of Public Health, at least two deaths have been reported leaving a number of other people quarantined. The health ministry says they have the situation under control; however, they call for vigilance. Ms. Margueritte Maliévo Samba said, "I call all the Central African population in general and that of the Prefecture of Mbomou especially for calm and strict respect for preventive measures that were to wash hands regularly, avoid any manipulation with sick or dead animals and secretions of infected person and objects.". This is the 3rd time monkeypox has been reported in CAR. Previously it was seen in Mbomou in 2001 and two years ago in Haute Kotto.. Monkeypox is a relatively rare disease caused by the virus with the same name, which is found primarily in central and western Africa.. It is closely related to the smallpox virus (variola), the virus used in the smallpox vaccine (vaccinia), and the cowpox virus.. Infection with monkeypox is not as serious as its cousin, ...
Prairie dogs native to both North and Central America are small stout-bodied burrowing rodents with shallow cheek pouches. An average size is 12 to 16 inches (30 to 40 cm) long.. In the United States prairie dogs are primarily found west of the Mississippi River, but they have been introduced into a few eastern locales. All are herbivores, and in settled regions they sometimes damage crops severely. They have been eliminated from certain areas of the Great Plains where ranchers regard them as pests. The mass culling of prairie dogs has lead to the near extinction of the black-footed ferret, which eats the prairie dog.. The White-tailed Prairie Dog was described by Ludvig/Louis, and was named after the 1805 Lewis and Clark Expedition where prairie dogs were first identified for scientific study. In 2003 they came to public attention in the U.S. because pet prairie dogs spread monkeypox, a mild variant of smallpox previously unknown in North America, to more than a dozen people. The prairie dogs ...
Anambra state government has reacted to allegations being peddled by IPOB members that military officers in the state have invaded some schools and are injecting students with the monkeypox virus.
To many people in the west, Prairie dogs are abundant pests which ranchers, developers and public land managers try to kill off. The pudgy short-tailed cousin of the squirrel lives in networks of burrows called prairie dog towns, and alongside highways. But, the perception of the prairie dog is increasingly at odds with reality. As Kelly Griffin reports from Denver, biologists are trying to convince skeptical westerners that the prairie dog, and with it the plains eco-system, are in trouble.
The order Rodentia is the most speciose group of mammals with muroids being the most diverse superfamily. Since they are represented in arboreal, semiaquatic, subterranean and terrestrial niches, rodents may exhibit morphological traits reflecting their adaptations to such diverse environments. This thesis focuses on the morphology of the endocranium, auditory bulla and cochlea in three tribes (Otomyini, Taterillini and Gerbillini) representing 10 species of African rodents, concentrating on their variability, function and adaptability, using micro-CT imaging and 3D shape comparative methods. Additionally, variations in cranial size were also studied in respective of global warming and climatic variables. Morphological changes/variations are a result of environmental change, therefore each chapter in this study details the effect of environmental change (in space and time) on different morphological traits i.e. general cranial size (chapter 2), cochlea and auditory bulla (chapter 3) and ...
According Okoroukwu, "I can tell you authoritatively that there is no confirmed case of monkey pox in the territory.. READ ALSO: MonkeyPox hits Ekiti State, two cases confirmed. "Nobody should panic because we have not confirmed any case and do not hope to confirm any and there is nothing wrong for people to report any suspected case," he said.. The director enjoined residents to practice good hygiene in order to reduce the possibility chances of contracting the disease.. He added that rodents and monkeys of Africa specie are the vectors of monkeypox.. He therefore advised residents to avoid direct contact with such animals, dead or alive, and people suspected to be infected.. Okoroukwu also enjoined health workers to take the stipulated standard precautions while discharging their duties.. Meanwhile, cases of Monkey Pox have been reported in Bayelsa, Rivers, Lagos and Ekiti states.. ...
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By 2050, deforestation could cause temperatures in the Congo Basin to increase by 0.7 °C. The increase would intensify warming caused by greenhouse gases by half, according to a study by researchers at the University of ...
A vaccine developed in Wisconsin has been shown to protect prairie dogs from the plague, a bacterial disease that has sickened three people …
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Today was the perfect chance to try out my new camera--okay, so truth to tell, I went ahead and bought it so I would have it for today. The picture below was taken in Kids and Pets mode (the pets are in the back) with a Canon PowerShot SX100 IS w/o flash, ISO 250, f 2.8 at 8.3 Mpx w/ medium compression. I havent learned much about settings yet, so thats pretty much how it came out of the box (sized down for the web). Theres a lot of redeye, and its supposed to fix that--my Nikon D50 at school has that, too, but its hit-or-miss, and that camera cost over three times what this one did. Still, I think this is just about the best digicam available before jumping up to dSLRs--in both price and size ...
I would like to introduce my new project for my 1989 SC 5spd. Currently my car has a perfectly good 4.2 engine with an MPX that makes over 380whp on pump gas. It won its dyno class (M90) at the 2016 shootout. Its running somewhere in the high 12s at the track, trapping ~107mph, and it probably should go mid 12s with a better driver. It s a great car, and I enjoy driving it to work when the weather is nice, which is most of the year down here in NC. I have learned a tremendous amount from
With the Xsara Picasso, C4 Picasso, Grand C4 Picasso and C3 Picasso, Citroën has a considerable number of vehicles in the compact MPV segment. Since 1999, the brand has sold almost 3 million Picassos.