TY - JOUR. T1 - Molecular Probe Data Base (MPDB). AU - Campi, Maria Giuseppina. AU - Romano, Paolo. AU - Milanesi, Luciano. AU - Marra, Domenico. AU - Manniello, Maria Assunta. AU - Lannotta, Beatrice. AU - Rondanina, Gabriella. AU - Grasso, Elena. AU - Ruzzon, Tiziana. AU - Santi, Leonardo. PY - 1998/1/1. Y1 - 1998/1/1. N2 - In this paper, the current status of the Molecular Probe Data Base (http://www.biotech.ist.unige.it/interlab/mpdb.html) is briefly presented together with a short analysis of its activity during 1997. This has been performed by statistically evaluating the logs of the Internet servers that are used for its distribution with reference to the geographical origin of the requests, the words that were utilized to carry out of the searches and the oligonucleotides that were retrieved. Planned enhancements of this database are also described. They include a revision of its data structure and, even more relevant, of its data management procedures.. AB - In this paper, the current ...
The development of small-molecule inhibitors for perturbing enzyme function requires assays to confirm that the inhibitors interact with their enzymatic targets in vivo. Determining target engagement in vivo can be particularly challenging for poorly characterized enzymes that lack known biomarkers (e.g., endogenous substrates and products) to report on their inhibition. Here, we describe a competitive activity-based protein profiling (ABPP) method for measuring the binding of reversible inhibitors to enzymes in animal models. Key to the success of this approach is the use of activity-based probes that show tempered rates of reactivity with enzymes, such that competition for target engagement with reversible inhibitors can be measured in vivo. We apply the competitive ABPP strategy to evaluate a newly described class of piperazine amide reversible inhibitors for the serine hydrolases LYPLA1 and LYPLA2, two enzymes for which selective, in vivo active inhibitors are lacking. Competitive ABPP ...
Development of Functional Fluorescent Molecular Probes for the Detection of Biological Substances. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The work described in this thesis has led to the identification of an activity-based probe (ABP) for DAGL-α. This ABP was instrumental for the identification of a new class of highly selective DAGL inhibitors. These novel inhibitors can be used to investigate the role of the diacylglycerol lipases in metabolic syndrome and neurodegenerative diseases such a Parkinsons disease, Alzheimers disease and Multiple Sclerosis ...
BACKGROUND: In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. METHODS: We sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a CDH1germline mutation for germline variants affecting CTNNA1, MAP3K6 and MYD88 using a targeted next-generation sequencing approach based on single-molecule molecular inversion probes ...
Tan, M. S. Y., Davison, D., Sanchez, M. I., Anderson, B. M., Howell, S., Snijders, A. P., Edgington-Mitchell, L. E. & Deu, E. (2020). Correction: Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.. PLoS One, 15 (3), pp.e0231231-. https://doi.org/10.1371/journal.pone.0231231. ...
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Molecular Probes APEX Alexa Fluor 647 Antibody Labeling Kit 1 kit Life Sciences:Protein Biology:Crosslinking, Labeling and Protein Modification:Protein Labeling Reagents:Fluorescent
A variety of molecular probes were synthesized and characterized with the goal of gaining structural, conformational, and mechanistic information on polymerases. The leaving group effects of β,γ-CXY deoxynucleotide probes was investigated in order to determine the rate-determining step in the nucleotidyl mechanism of pol β. Due to inconsistencies in literature the pKa₍₂₋₄₎ values for nine bisphosphonic acids used to comprise the β,γ−CXY toolkit were determined under identical conditions. Applying these acidity constants to the analysis of kinetic results obtained with a series of dGTP-β,γ−CXY analogues clarified the relationship between the rate of single-gap nucleotide insertion and BP pKa₄ values. Through construct of Brønsted LFER plot results seem to indicate that chemistry and not conformation is the rate-limiting step in the nucleotidyl transfer mechanism. ❧ Modification on the Pᵧ of α,β-CH₂ non-hydrolyzable dATP analogs were synthesized to probe the ...
A new fluorescence-based molecular probe can detect multiple sclerosis (MS) at its earliest stage - even before the onset of physical signs.
Molecular Probes Cell Imaging Guide with Protocols brbrThis mobile app is designed to help you find fluorescent dyes reagents and protocols for cell biology related fluorescence microscopy applications brbrMolecular Probes mobile app
Researchers at the Stanford University School of Medicine have developed a molecular probe that sets aglow tumor cells within living animals. Their goal is to use the probe to improve the diagnosis and treatment of cancer and other diseases.
Vanderbilt Specialized Chemistry Center for Accelerated Probe Development is a member of the MLPCN, initiated and supported by the NIH. Centers mission is to develop small molecule probes as molecular targets with exceptional potency and selectivity for exploring the functions of genes and pathways in health and disease at the molecular and cellular and in vivo levels.
Chemical engineers at UC Santa Barbara expect that their new process to create molecular probes may eventually result in the development of new drugs to treat cancer and other illnesses.
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Shop a large selection of Protein Labeling Reagents products and learn more about Molecular Probes Zenon Mouse IgG1 Labeling Kit 1 kit:Life Sciences 1 kit.
Breaking news and analysis of the global biotechnology, pharmaceutical, medical device and medical technology sectors. In-depth coverage of innovation, business, financing, regulation, science, product development, clinical trials and more
Our research involves the chemical biology of protein post-translational modifcations (PTMs) in the context of signaling, epigenetics, and cancer. We develop and apply chemical approaches including protein semisynthesis and small molecule probes to the study of protein phosphorylation, acetylation, ubiquitination, and other PTMs in enzymes and cellular networks. We are currently investigating the functions, regulation, and mechanisms of PTEN lipid phosphatase, Akt protein kinase, NEDD4 ubiquitin ligases, LSD1 histone demethylase, HDAC1 deacetylase, the CoREST complex, and p300/CBP acetyltransferase. We strive to translate our findings in signaling and epigenetics to identify novel therapeutic opportunities for the treatment of cancer and other diseases ...
The testo Saveris H4 D radio probe has a connection option for an external humidity/temperature probe and is therefore ideal for monitoring ambient conditions in buildings and warehouses.
The testo Saveris T1 D radio probe is equipped with an internal temperature sensor. It is EN 12830-compliant and is therefore ideal for monitoring temperatures in the food industry.
TomTom is the only independent mapmaker in the world today, and has been making maps for the worlds largest technology companies, car manufacturers, fleet m...
Principal Investigator：IDE Hiroshi, Project Period (FY)：1997 - 1999, Research Category：Grant-in-Aid for Scientific Research (B), Section：展開研究, Research Field：環境影響評価(含放射線生物学)
CHANGZHOU, China - On a dusty lane in east China, a small factory sitting amid strawberry and vegetable fields processes chemicals from pig guts into heparin, a commonly used blood thinner linked to 62 deaths and hundreds of allergic reactions in the U.S. and Germany ...
1. Make sure you or your loved one is actively participating in therapy. If not, the benefits of therapy will be very minimal. Passive therapy should be implemented only for a short time and a short duration.
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We now coverslip with Molecular Probes Prolong Gold antifade reagent, with or without DAPI. We have found some antifade mounting medias cause fading if left overnight, but if the slides are examined right after staining, fading has not occured. So be careful about what antifade mounting medias you use. Also, some fluorophores do not withstand mounting medias and will fade right away. I believe Cy2 is one, and also Alexa 630 - Jackson and Molecular Probes provide this information. We have found RRX (rhodamine red extra) from Jackson Immunorearch, is more reisistant to staining than TRITC, both are derivatives from fluorescein but have different chemical structures. We dont bother to refrigerate but do keep the sections in the dark and try to view them the next day after staining,coverslipping. Selection of fluorophore is important, and Alexa dyes are more resistant to fading and also much brighter than fluorescein related fluorophores (FITC, Rhodamine, Texas Red). It is important to learn about ...
Accurate localization of diseases in humans, especially at advanced stages, is widely accomplished by modern imaging methods such as magnetic resonance imaging...
Principal Investigator：KOBAYASHI Motomasa, Project Period (FY)：2003 - 2004, Research Category：Grant-in-Aid for Scientific Research (B), Section：一般, Research Field：Living organism molecular science
Molecular Probes offers a Yeast Viability Kit (Product number is 7009) ------------------------------------------------ Mahesh K. Bhalgat, Ph.D. Staff Scientist/Flow Cytometry Product Manager Molecular Probes, Inc. OREGON ------------------------------------------------ John wrote: , Hi All, , , A coleague of mine is interested in doing yeast viability assays on , our , Coulter XL, , Does anybody have a good system for this, we have tried PI but it , appears , that it does not cross the cell wall to easily. , , Many Thanks , , John ...
FluoroNanogold is a unique probe containing both Nanogold® and fluorescein. You can use it for truly correlative labeling on the cellular and macromolecular level, or for checking your labeling by fluorescence before EM processing. Catalog information about FluoroNanogold: www.nanoprobes.com/FluoroN.html Because FluoroNanogold combines two labels which are frequently used in different concentrations under different conditions, some optimization may be required to obtain the best performance in your experiments. For tips and tricks on FluoroNanogold labeling, and how to obtain the cleanest signal, visit our technical help page: Technical help for FluoroNanogold: www.nanoprobes.com/TechFN.html Look out for combined fluorescent and gold probes with other fluorophores: when these are available, we will announce them on our web site (www.nanoprobes.com). Original papers: Powell, R. D.; Halsey, C. M. R.; Spector, D. L.; Kaurin, S. L.; McCann, J.;, and Hainfeld, J. F. A covalent fluorescent-gold ...
Angela Koehler is an institute member at the Broad Institute of MIT and Harvard and a member of the steering committee for the Broads Cancer Program. Her research group aims to discover and develop functional small-molecule probes of transcriptional regulators, including chromatin modifying enzymes and oncogenic transcription factors. Validated probes may be used to advance
Rutgers University June 26, 2017 Todd B. Bates New DNA-based LASSO molecule probe can bind target genome regions for functional cloning and analysis. Photo: Jennifer E. Fairman/JHU Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at…
Clearly the researchers didnt start out trying to disprove the role of DDR1/2 in squamous cell lung cancer, but their efforts will save others from pursuing the same course. The publication introduces some attractive chemical probes for interrogating the biology of these receptors; hopefully one of these molecules will be added to the Chemical Probes Portal as an alternative to the less-selective probes that have been used in previous studies. Who knows, perhaps someone will find another indication for which DDR1/2 inhibitors are just the ticket ...
koteswararao2kanugula at gmail.com wrote: , Dear sir, , This is koteswara rao , I am facing the problem of , coupling reaction as well as identification of the hapten + protien , coupling. Both Molecular Probes (www.probes.com) and Pierce (www.piercenet.com) discuss cross-linkers in their respective catalogues, which are available online ...
Also the Alexa kits from Molecular Probes. Typically, you need 100 ug of protein, although there is a microscale labeling kit that works with as little as 20 ug, if I remember correctly.. ...
Southern blot definition is - a blot consisting of a nitrocellulose or nylon sheet containing spots of DNA for identification by a suitable molecular probe.
The authors used time-driven activity-based costing method to calculate the costs of treating individual patients with specific medical conditions over their full cycle of care. We discussed how TDABC provides a critical, systematic and data-driven approach to estimate costs accurately and dynamically, as well as its potential to enable structural and rational cost reduction to bring about a sustainable healthcare system.
Activity-based costing (ABC) is a costing model that identifies activities in an organization and assigns the cost of each activity resource to all products an…
Free Essay: Activity-Based Costing (ABC) in Service Industries H & R Block H & R Block A Study of TDABC Costing Robert Kaplan defines activity based...
GSK2801 is a useful probe for BAZ2A and BAZ2B bromodomains. While it has encouraging selectivity relative to other bromodomains, the utility GSK2801 is somewhat limited by weak potency, requiring it to be employed at micromolar concentrations in cellular studies. ...
This probe represents the best in class for SUV420H1 and H2 - hitting the enzymes at 25 and 144 nM, respectively, with selectivity data against a wide panel of related epigenetic and other targets. The originating paper gives good confidence around this molecule and includes strong biochemical, biophysical, structural & cellular data, as well as structurally related negative controls. No data are presented for the wider pharmacokinetic, drug-like profiles, and so no conclusion can be drawn on its suitability as a probe for use in model organism studies. However, permeability from cellular studies and chemical structure would support its further investigation towards these studies.. ...
Fluorescent Molecular Rotors are sensors of microenvironmental restriction that become fluorescent only if their rotation is constrained. It has been suggested that the change of fluorescence intensity is caused by the restriction of intramolecular rotational relaxation about the donor-acceptor bond of the fluorophores.Examples of molecular constraint include increased dye (aggregation)1, binding to antibodies2, or being trapped in the polymerization of actin3. There are also studies of membrane fluidity in endothelial cells under fluid shear stress4 where fluorescent molecular rotors are used.1. Bhattacharyya, A. et al., Indian J. Biochem. Biophys., 32, 442-446 (1995).2. Iwaki, T. et al., Biochem., 32, 7589-7592 (1993).3. Sawada, S. et al., Anal. Biochem., 204, 110-117 (1992).4. Farkas, D.L. and Leif R.C. (ed.), Optical diagnostics of living cells III, Proc SPIE 3291, 101-112 (2000
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This graph shows the total number of publications written about Molecular Probe Techniques by people in this website by year, and whether Molecular Probe Techniques was a major or minor topic of these publications ...
Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of ...
Fluorescent molecular imaging helped surgeons visually identify lung adenocarcinomas during pulmonary resection, according to study results.
Molecular Probes fluorescence reagents are among the most peer-referenced in all of life science research. Trusted product bands including Alexa Fluor, SYTOX and Click-iT empower scientists working in cell biology, genetic analysis, protein biology, and cell engineering to make the discoveries that advance our understanding today and catalyze the research goals of tomorrow.
Molecules with ionizable protons, with different proton transfer efficiencies in the excited and ground states, show excited state prototropism (ESPT). In suitable proton donating/accepting environments, ESPT of a molecule can result in the observation of emissions from different prototropic species, each ch 2019 Perspective article collection
Tom Barkers research identifies molecular probes capable of selectively attaching to fibronectin fibers under different strain states, enabling the detection and examination of fibronectin strain events in both culture and living tissues.. ...
Surface properties of silica gel and silica gel-supported ion-exchanged copper in transformations of various molecular probes: an infrared study ...
During the last decade, the development of nuclear spin polarization enhanced (hyperpolarized) molecular probes has opened up new opportunities for studying the inner workings of living cells in real time. The hyperpolarized probes are produced ex situ, introduced into biological systems and detected with high sensitivity and contrast against background signals using high resolution NMR spectroscopy. A variety of natural, derivatized and designed hyperpolarized probes has emerged for diverse biological studies including assays of intracellular reaction progression, pathway kinetics, probe uptake and export, pH, redox state, reactive oxygen species, ion concentrations, drug efficacy or oncogenic signaling. These probes are readily used directly under natural conditions in biofluids and are often directly developed and optimized for cellular assays, thus leaving little doubt about their specificity and utility under biologically relevant conditions. Hyperpolarized molecular probes for biological NMR
My research group is engaged at the interface of chemistry and biology. As medicinal chemists, we design and synthesize small molecules (about 25 to 75 atoms) that modulate disease pathology at the level of the enzyme, cell, and whole animal, with current projects in cancer, infectious disease, and neurodegeneration. Using such small molecule probes, we are exploring the mechanisms underlying the action of artemisinin and related antimalarial drugs. Finally, we are inventing and employing new platform technologies in an effort to expand the realm of druggable target space and drug-like chemical space. These technologies include fragment-based approaches to target protein-protein interfaces and allosteric modulation of enzymes, the use of novel unnatural amino acids to discover cell-permeable peptides, and new targeted prodrug approaches in cancer and infectious disease.. This project is an evaluation of ferrous-iron targeted drug delivery that exploits the high ferrous iron concentrations in ...
Proteases are one of the largest and best-characterized families of enzymes in the human proteome. Unfortunately, the understanding of protease function in the context of complex proteolytic cascades remains in its infancy. One major reason for this gap in understanding is the lack of technologies t …
여기서는 활동 기반 프로브의 제조 및 사용을 설명 (ARN14686, 운데 10 ynyl- N - [(3- S) -2- oxoazetidin -3- 일] 카르 바 메이트)의 검출 및 정량화를 허용 염증성 효소 ...
Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosphonate (FP) probes has been a powerful chemoproteomic approach in studies unveiling roles of SHs in various biological systems. ABPP utilizes cell/tissue proteomes and features the FP-warhead, linked to a fluorescent reporter for in-gel fluorescence imaging or a biotin tag for streptavidin enrichment and LC-MS/MS-based target identification. Existing ABPP approaches characterize global SH activity based on mobility in gel or MS-based target identification and cannot reveal the identity of the cell-type responsible for an individual SH activity originating from complex proteomes. Here, by using an activity probe with broad reactivity towards the SH family, we advance the ABPP methodology to glioma brain cryosections, enabling for the first time high-resolution
For decades researchers have been using the famous Alexa Fluor dyes developed by Molecular Probes for everything from flow cytometry to oligonucleotide labeling. The original Molecular Probes patents have likely limited the number of companies offering less expensive alternatives to the Alexa Fluor dyes. Innovative dyes as DyLight and IRDyes have been developed and are used for specific applications, but direct alternatives for the standard Alexa Fluor exitation and emission spectra dyes have been difficult/impossible to find ..until now. ...
Reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. Can replace Alexa Fluor 647, DyLight 649 ...
The SYPRO dyes, which were developed by Molecular Probes, bind to the lipid coating around proteins in SDS gels and not to the protein itself. I would not expect any interaction with 35-S. If necessary, the dyes can be extracted from the proteins with organic solvents such as alcohol and, following transfer, do not interfere with immunoblotting. Dick Haugland, President Molecular Probes, Inc. dick at probes.com ...
The MALDI Tissuetyper is a system that records spatially resolved mass spectra directly from tissue. This allows the direct measurement of proteins, lipids and other molecular classes without the need for antibodies or molecular probes. This results in highly multiplexed datasets in which hundreds or thousands of compounds are measured simultaneously. , The MALDI Tissuetyper is a system that records spatially resolved mass spectra directly from tissue. This allows the direct measurement of proteins, lipids and other molecular classes without the need for antibodies or molecular probes. This results in highly multiplexed datasets in which hundreds or thousands of compounds are measured simultaneously.
The Cancer Therapeutics Response Portal v1 provides open access to the results obtained through quantitatively measuring the sensitivity of 242 genetically characterized cancer-cell lines to a 354-member Informer Set of small-molecule probes and drugs. Statistically significant correlations identified between the genetic and lineage features of the cell lines and small-molecule sensitivities are accessible through the portal. With this dataset, users can mine for genetic correlations in a lineage-specific context and control for potential confounding factors. We anticipate continuing to expand the dataset in the portal, providing a living resource for the cancer-research community. We hope that the Portal can be used to develop novel therapeutic hypotheses and to accelerate future discovery of drugs matched to patients based on their cancer genotype and lineage ...
H2S - along with nitric oxide, carbon monoxide and others in this emerging class of gaseous signaling molecules - assists the bodys large proteins. Large proteins do much of the functional work in the body, such as digesting the food we eat and harnessing the energy in the oxygen we breathe. Their size, however, forces them to move slowly inside the cell. In contrast, H2S and other small gaseous molecules diffuse quickly and easily across cellular membranes, enabling them to travel much faster and rapidly deliver information that mediates critical functions, such as blood pressure regulation, Lippert said.. For their experiments, Lippert and Lin placed living endothelial cells cultured from the internal lining of a blood vessel into a petri dish under a microscope. Lippert and Lin then added a chemical solution containing an azide-functionalized organic molecule that theyd synthesized to act as a molecular probe. They gave the cells time to absorb the probe, then added a protein solution known ...
A new analytics report from Nature Index - Indian Science Ascending - released today, notes a surge in high-quality scientific publication in India between 2012 and 2014. The report, produced jointly by Springer Nature and the Confederation of Indian Industry (CII), reveals that in high tier journals, Indian academic institutions co-author more papers with international companies than with domestic firms. The report was released at the CII Global Higher Education summit in New Delhi.. The analysis is the first of a new style of reports that further probe data from the Nature Index to answer questions about Indias place in global science, especially when compared with countries that have similar volumes of index output in 2014 and with broadly similar economic conditions (including Australia, Brazil, Italy, Russia, Singapore, South Korea and Taiwan).. The Nature Index database tracks the author affiliations of nearly 60,000 scientific articles published in an independently selected group of 68 ...
Biocombinatorially selected solid-binding peptides, through their unique material affinity and selectivity, are a promising platform for building up complex hierarchical assemblies of nanoscale materials and molecular probes, targeted to specific practical solid surfaces. Here, we demonstrate the material-sp
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Results of molecular beacon end-point assays using the E8/E9 and E9/E10 probes on a representative genomic DNA panel. There is no difficulty in distinguishing a
Protean agonists are of great pharmacological interest as their behavior may change in magnitude and direction depending on the constitutive activity of a receptor. Yet, this intriguing phenomenon has been poorly described and understood, due to the lack of stable experimental systems and design strategies. Here, we overcome both limitations: First, we demonstrate that modulation of the ionic strength in a defined experimental set-up allows for analysis of GPCR activation in the absence and presence of a specific amount of spontaneous receptor activity using the muscarinic M2 acetylcholine receptor as a model. Second, we employ this assay system to show that a dualsteric design principle, i.e. molecular probes, carrying two pharmacophores to simultaneously adopt orthosteric and allosteric topography within a G protein-coupled receptor, may represent a novel approach to achieve protean agonism. We pinpoint three molecular requirements within dualsteric compounds that elicit protean agonism at the ...
The TS2000-SE from MPI is the first ever 200mm automated engineering probe system on the market integrating innovative features specifically designed to reduce the cost of test. These features are incorporated into the MPI ShielDEnvironment™ for ultra-low noise, very accurate and highly reliable DC/CV, RF and High Power measurements.。Wafer Probe Stations | Probe Stations | 200mm Probe Stations | Automatic Probe Stations | 200mm Automated Probe Stations | Wafer Probe Systems | 200mm Probe System
Near-infrared optical guided surgery of highly infiltrative fibrosarcomas in cats using an anti-$\alpha$vss3 integrin molecular probe., Wenk, Christiane H. F., Ponce Frederique, Guillermet Stephanie, Tenaud Corinne, Boturyn Didier, Dumy Pascal, Watrelot-Virieux Dorothee, Carozzo Claude, Josserand Veronique, and Coll Jean-Luc. , Cancer Lett. (New York, NY, United States), Volume 334, Number 2, p.188-195, (2013) ...
A central pathogen virulence mechanism is their ability to secrete pathogen proteins, called effectors, that modulate their host during infection. We are using effectors as molecular probes to better understand how bacteria cause disease. We are also investigating the role of post-translational modifications during plant immune signaling. ...
This note discusses the expected contributions of the activity-based research approach to the general development of transport planning. Against a brief review of the development of the approach and its central tenets it discusses four areas in turn: data collection, models of household interactions, choice models incorporating the whole daily activity chain and finally explicit micro-simulation models of activity scheduling. The final section highlights the expected contributions and the possible difficulties of their acceptance into the planning process.
The University of Sydney, in partnership with Southern Cross University and the Cachet Group is collaborating in a study to assess the impact of activity-based working in Australian offices.
Scientists from MIT have devised a new probe that enables them to image molecules in the brain without using any chemical or radioactive agents. The new probe consists of proteins and once it hits a particular target, the probe induces blood flow changes
A probe driving method and a probe apparatus for bringing a probe into contact with the surface of a sample in a safe and efficient manner by monitoring the probe height. Information about the height of the probe from the sample surface is obtained by detecting a probe shadow (54) appearing immediately before the probe contacts the sample, or based on a change in relative positions of a probe image and a sample image that are formed as an ion beam is irradiated diagonally.
The GA4GH (Global Alliance for Genomics and & Health) Beacon Projectis a project to encourage international sites to share genetic data in the simplest of all technical contexts. The service is designed merely to accept a query of the form Do you have any genomes with an A at position 100,735 on chromosome 3 (or similar data) and responds with one of Yes or No.. The Beacon Network lists all the known beacons.. For programmatic access to the COSMIC beacon, the minimal URL for the request is ...
Production of near-field microscopy gets scaled up under the direction of experts at The Molecular Foundry at Lawrence Berkeley Laboratory
This site provides an animated simulation to learn about the use of a probe to locate genes in specific organisms. A gene sequence is presented and step-by-step instructions are used to explain the uniqueness of DNA and how probes are designed. ...
Chi- squared is also know as the goodness of fit, this means that it tests the shape and proportion of the data in relation to the null. the goodness of fit if tested by comparing the observed frequencies with the distribution set in the null hypothesis. chi squared in my eyes is the most understandable of all the statistical tests as there is no…
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The purpose of this study is to answer two main questions: Is switching behaviour in Activity-based working (ABW) environments related to satisfaction with ABW environments? Which factors may explain switching behaviour?
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হিস্টিরিয়া একটি নিউরোসিস রোগ। এ রোগটি শারীরিক সমস্যা বা মানসিক সমস্যা নিয়ে প্রকাশ পেতে পারে।যাদের হিস্টিরিয়া রয়েছে তারা সাধারণত কোনো না কোনো ফোবিয়ায় আক্রান্ত, অনিয়মতান্ত্রিক জীবন-যাপন ও মানসিক অবসাদগ্রস্ত থাকেন।