Solution 3 (EMS +2FOC on the shoulder and on the upperarm) HALLOW SHAFT MOTOR J1 J2J3 ELBOW HAND ETH_IN ETH_OUT PS_DC_MOTORS CAN_SKIN2 CAN_FTSENSOR ETH_IN ETH_OUT PS_DC_MOTORS CAN_SKIN2 CAN_FTSENSOR ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS CAN_FTSENSORS 2 Absolute encoder 1 incremental enc 1 hall phase 1 motor phase 1 CAN_SKIN ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS CAN_FTSENSORS 2 Absolute encoder 1 incremental enc 1 hall phase 1 motor phase 1 CAN_SKIN ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS CAN_FTSENSORS 1 HALL sensor 1 MOTOR PHASE 1 Absolute encoder ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS CAN_FTSENSORS 1 HALL sensor 1 MOTOR PHASE 1 Absolute encoder ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS CAN_FTSENSORS ETH_IN ETH_OUT PS_DC_MOTORS PS_BLDC_MOTORS CAN_FTSENSORS
Molecular motor proteins use the energy released from ATP hydrolysis to generate force and haul cargoes alongcytoskeletal ?laments. Thus, measuring the force motors generate amounts to directly probing their function. We report onoptical trapping methodology capable of making precise in vivo stall-force measurements of individual cargoes hauled by molecular motors in their native environment. Despite routine measurement of motor forces in vitro, performing and calibrating suchmeasurements in vivo has been challenging. We describe the methodology recently developed to overcome these dif?culties,and used to measure stall forces of both kinesin-1 and cytoplasmic dynein-driven lipid droplets in Drosophila embryos. Critically,by measuring the cargo dynamics in the optical trap, we ?nd that there is memory: it is more likely for a cargo to resume motion inthe same directionrather than reverse directionafter the motors transporting it detach from the microtubule under the force ofthe optical trap. ...
Research in our lab is focused on motor proteins, which are molecular machines that drive cargo along tracks to specific sites in the cell, like a train running along a railway network to its specific destinations. New results now show that these molecular motor proteins may play a crucial role in the pathway that eliminates damaged mitochondria. In this project, we will use a number of techniques to identify how these motor proteins or its cargo hooks associate with the machinery that mediates cellular quality control. In addition, we will test whether eliminating the molecular motors inhibits turnover of damaged cell parts leading to an accumulation of non-functional mitochondria and reduced energy production. Relevance to Diagnosis/Treatment of Parkinson s Disease ...
Designing molecular motors is rarely an intuitive process because behaviour at the molecular level is often very different to what we observe in our big world. … In the mechanical machines we are familiar with the parts (cogs, flywheels, pistons etc) do not move unless and until a force is applied to make them do so. At the molecular scale, however, molecules and their parts are constantly moving through Brownian motion and it is finding ways to control the directionality of that motion that is the key to developing working nanomachines. Now, scientists at the University of Manchester have invented a synthetic molecular motor that runs off chemical energy in a similar manner to the way that motor proteins use ATP (adenosine triphosphate) as a fuel …] In the man-made nanomotor, a synthetic molecular ring moves directionally around a molecular track powered by the motors catalysis of chemical reactions of a fuel. Remarkably, the motor mechanism depends on information transfer about the ...
A body fluid sampling system for use on a tissue site includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator.
Cytoplasmic dynein and kinesin-1 are opposite-polarity, microtubule-based motors that transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate bi-directional movement due to the presence of ensembles of dynein and kinesin but are ultimately sorted with spatial and temporal precision. To investigate the mechanisms that coordinate motor ensemble behavior, we built a programmable synthetic cargo using three-dimensional DNA origami to which varying numbers of DNA oligonucleotide-linked motors could be attached, allowing control of motor type, number, spacing, and orientation in vitro. In ensembles of 1-7 identical-polarity motors, motor number had minimal affect on directional velocity, while ensembles of opposite-polarity motors engaged in a tug-of-war resolvable by disengaging one motor species.. ...
doc, Research in my laboratory focuses on spindle and chromosome dynamics and the mechanisms that ensure proper chromosome transmission and inheritance in dividing cells. Work in my laboratory and others over the past 5-10 years has identified molecular motor proteins as the force-generating proteins underlying movements of the spindle and chromosomes during cell division. Much of our current effort is directed towards understanding the mechanism of motor function, including the molecular basis of motor directionality, and the contribution of motor proteins to spindle and chromosome dynamics in living cells. ,br/, ,br/,During the past several years, we have used molecular genetics to determine the basis of the reversed directionality compared to kinesin of the Ncd motor protein, discovered in my laboratory. Ncd is a microtubule motor that is required for proper spindle assembly in oocytes and early embryos of Drosophila. We showed previously that Ncd moves on microtubules in the opposite ...
The presence of membrane tubules in living cells is essential to many biological processes. In cells, one mechanism to form nanosized lipid tubules is via molecular motor induced bilayer extraction. In this paper, we describe a simple experimental model to investigate the forces required for lipid tube formation using kinesin motors anchored to 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) vesicles. Previous related studies have used molecular motors actively pulling on the membrane to extract a nanotube. Here, we invert the system geometry; molecular motors are used as static anchors linking DOPC vesicles to a two-dimensional microtubule network and an external flow is introduced to generate nanotubes facilitated by the drag force. We found that a drag force of ≈7 pN was sufficient for tubule extraction for vesicles ranging from 1 to 2 μm in radius. By our method, we found that the force generated by a single molecular motor was sufficient for membrane tubule extraction from a spherical ...
The ability of a neuron to regulate steady-state expression and transport dynamics of mRNA granules in axons and dendrites is believed to be modulated by mRNA binding proteins acting as adapters for molecular motors. While previous work has shown that ZBP1-mediated localization of β-actin mRNA into axons depends on microtubules (Zhang et al., 1999, 2001), it remains unclear what molecular motors are involved in the directed transport of ZBP1. Kinesin motors have been shown to play an important role in the transport of mRNAs and mRNA binding proteins in neurons (Kanai et al., 2004; Dictenberg et al., 2008). In these studies, perturbation of kinesin leads to a reduction in RNA granule localization in neuronal processes and impaired dynamics. Here, we report that perturbation of myosin Va leads to an opposite phenotype, characterized by increased levels and transport dynamics of ZBP1 in axons. These findings suggest that transport dynamics for ZBP1 and perhaps other mRNA granule components are ...
Molecular motors play important roles within a biological cell, performing functions such as intracellular transport and gene transcription. Recent experimental work suggests that there are many plausible biochemical mechanisms that molecules such as myosin-V could use to achieve motion. To account for the abundance of possible discrete-stochastic frameworks that can arise when modeling molecular motor walks, a generalized and straightforward graphical method for calculating their dynamic properties is presented. It allows the calculation of the velocity, dispersion, and randomness ratio for any proposed system through analysis of its structure. This article extends work of King and Altman ["A schematic method of deriving the rate laws of enzyme-catalyzed reactions," J. Phys. Chem. 60, 1375-1378 (1956)] on networks of enzymatic reactions by calculating additional dynamic properties for spatially hopping systems. Results for n-state systems are presented: single chain, parallel pathway, divided ...
PHARM 560 Cellular and Molecular Physiology: Molecular Machines in Human Disease. Emile Boulpaep. This course focuses on understanding the processes that transfer molecules across membranes at the cellular, molecular, biophysical, and physiological levels. Students learn about the different classes of molecular machines that mediate membrane transport, generate electrical currents, or perform mechanical displacement. Emphasis is placed upon the relationship between the molecular structures of membrane proteins, their normal function, and abnormal function in human disease. The interactions among transport proteins, their normal function, and abnormal function in human disease are also a focus. The interactions among transport proteins in determining the physiological behaviors of cells and tissues are also stressed. Molecular motors are introduced and their mechanical relationship to cell function is explored. Students read papers from scientific literature that establish the connections between ...
Cytoskeletal motor proteins generate mechanical forces, which drive numerous cellular processes that are essential for life.  Research in the Tyska laboratory is focused on elucidating the function of the actin cytoskeleton and its associated myosin motor proteins.  The context for our studies is the ‘brush border’: an array of actin-based protrusions known as microvilli, which extend from the surface of polarized epithelial cells.  In the gut, the brush border serves as the sole site of nutrient absorption and a barrier to micro-organisms that reside in the lumenal space.  Using an approach that combines biophysics, biochemistry, and cell biology, we are currently studying mechanisms that control microvillar dynamics, morphology, and function. We have also begun to dissect the mechanism of microvillar assembly, which was jumpstarted by our recent elucidation of the entire brush border proteome.  A broad long-term goal is to develop our understanding of molecules and
Cytoskeletal motor proteins generate mechanical forces, which drive numerous cellular processes that are essential for life.  Research in our laboratory is focused on elucidating the function of the actin cytoskeleton and its associated myosin motor proteins.  The context for our studies is the ‘brush border’: an array of actin-based protrusions known as microvilli, which extend from the surface of polarized epithelial cells.  In the gut, the brush border serves as the sole site of nutrient absorption and a barrier to micro-organisms that reside in the lumenal space.  Using an approach that combines biophysics, biochemistry, and cell biology, we are currently studying mechanisms that control microvillar dynamics, morphology, and function. We have also begun to dissect the mechanism of microvillar assembly, which was jump started by our recent elucidation of the entire brush border proteome.  A broad long-term goal is to develop our understanding of molecules and
The strong structural similarity between TrwB and other well known molecular motors, such as the ATP synthase or ring helicases, suggests that TrwB operates as a motor driving a DNA strand through the transport pore, using the energy derived from ATP hydrolysis. TrwB is the best model in a novel group of molecular motors involved in ssDNA transport across membranes; another example of biological molecular motors that convert chemical energy into mechanical work. We work with three ATPases that belong to the type IV secretion system: TrwB, TrwD and TrwK. These three motors are inserted in the inner membrane of the cell and are involved in different functions: DNA transport, protein unfolding and protein transport through the secretion channel, respectively. The results obtained with TrwB have enabled us to propose a common mechanism that could be shared by all members of this family of ATPases, regardless of their role. Continuing with this project, we will carry out structural and biochemical ...
Did you know inside our bodies are little motors that carry cargo inside of our cells? That is right our bodies have biological motors. These motors help to move important items inside of our cells. The motors move along tracks inside of our cells, the tracks start at the center of our cells and grow outward. The biological motors move along until they reach the place they need to go.
Understanding how tiny molecular motors called myosins use energy to fuel biological tasks like contracting muscles could lead to therapies for muscle diseases and cancers, says a team of researchers led by Penn State College of Medicine scientists.
Conversion of undirected energy input into directed motion on molecula. Molecular Motor Crossing The Frontier Of Classical To Quantum Tunneling Motion
Researchers have successfully used DNA origami to make smooth-muscle-like contractions in large networks of molecular motor systems, a discovery which could be applied in molecular robotics.
Get this from a library! RNA polymerases as molecular motors. [Henri Buc; Terence Strick; Royal Society of Chemistry (Great Britain);]
DNA transfer across membranes and between cells by conjugation is a clear example of a rapid and natural way to acquire new genetic information, not only between bacteria, but also between yeast, plants and even animal cells. All conjugative systems contain a key protein in the membrane to carry out this process: the DNA transporter. In our system, the DNA transporter is TrwB and its crystallographic structure has been recently solved. The strong structural similarity between TrwB and other well known molecular motors, such as the ATP synthase or ring helicases, suggests that TrwB operates as a motor driving a DNA strand through the transport pore, using the energy derived from ATP hydrolysis. TrwB is the best model in a novel group of molecular motors involved in ssDNA transport across membranes; another example of biological molecular motors that convert chemical energy into mechanical work. To analyze the activity of TrwB, we are going to apply an emerging technique: nanotechnology, which ...
Edemco (220v W/euro Plug) 890 Forc3 Ii Box Dryer (oversized). Combines The Force Of Three Motors At Your Command. Three Switches Against Three Motors-one Outlet! Have One Motor On For 99 Cfm, Two Motors On For 19 Cfm, Or Three Fot 297 Cfm. The Flexible Tubing Is 6 Long Tp Accommodate Your Choice Of Either Cage Drying (hands Free), Or Drying By Hand. Cold Rolled Steell Housing For Durability. Includes 6 Hose, One Cage Attachment, And 8 Line Cord.-99-198-297 Cfm, 3,000 - 35,000 Fpm, 85 Degrees F. This Item Ships Oversized And Requires An Additional Freight Load Which Will Be Added To The Order. This Drop-shkp Item Ships Directly From The Manufacture And May Not Be Available For Speedy conveyance Shipping. Please Allkw Two To Three Weeks For Delivery. Available In White ...
2 2 FailuresReasonsCountermeasures Press cylinder doesnt work 1)Cylinder solenoid EDI valve voltage shorted, disconnected or burnt. 2)Cylinder limitation control switches no signal. 1)To check the voltage of electric circuit or to replace the coil. 2)To check cylinder limitation control switches. Oil temperature too high 1)Poor cooling efficient of cooler. 2)Cooler blocked by limescale. 1)To increase cooling water flowing volume and pressure. 2)To clean or to replace cooler. Oil pressure increasing irregularly 1)Scraps blocked in pump or tank. 2)Air entered into internal of pump. 3)Impeller of pump wears out. 1)To clean pump & oil filter. 2)To check O-ring fixed screws on the flange of oil sucking tube. 3)To replace the impeller. Non pressure 1)Pressure adjusting valve blocked. 2)Coil of directional valve burnt. 3)Directional valve circuit disconnected. 4)Directional valve breakdown. 1)To clean pressure adjusting valve. 2)To replace new coil. 3)To check circuit connection. 4)To replace new ...
Description: Apparatus wherein the pump and motor are constructed to operate when completely surrounded by the fluid to be pumped ...
WikiWealths Five Forces analysis evaluates the five factors that determine industry competition. Add your input to apollo-food-holding-berhads five forces template. See WikiWealths tutorial for help. Is WikiWealth missing any analysis? Check out our entire database of free five forces reports or use our five forces generator to create your own. Remember, vote up apollo-food-holding-berhads most important five forces statements.. ...
About a month ago, I was presenting an idea to make drones faster on race tracks: The so called side force generators (SFGs) enable racing drones to drift less during turns, making them potentially faster. The placement of the wings is very critical and mentioned in more detail in my earlier post on SFGs. Some people tested the SFGs and confirmed the enhanced flight characteristics. Other people didnt try and didnt believe that SFGs could help. I must agree that the concept of the SFGs is not so easy to understand. That is why I will explain it in more detail here ...
About a month ago, I was presenting an idea to make drones faster on race tracks: The so called side force generators (SFGs) enable racing drones to drift less during turns, making them potentially faster. The placement of the wings is very critical and mentioned in more detail in my earlier post on SFGs. Some people tested the SFGs and confirmed the enhanced flight characteristics. Other people didnt try and didnt believe that SFGs could help. I must agree that the concept of the SFGs is not so easy to understand. That is why I will explain it in more detail here ...
Axonal transport is a critical aspect of neuronal cell biology. While the understanding of the biophysical property of the microtubule motors has been established, the regulation of motor proteins are much less well understood, especially in vivo. In this presentation, I will discuss our past and current effort in characterizing the regulatory mechanisms of KIF1A mediated trafficking of synaptic vesicle precursors and dynein mediated retrograde trafficking ...
Calorie goal workouts: Sole F63 treadmill incorporates the latest technology to come up with a machine that provides efficient workouts.. One of the installed technology is the Calorie goal workout plan. The treadmill allows you to choose between different calorie workouts. This will be important if you are trying to lose weight and calorie goals are what you need. While any treadmill workout can ensure weight loss, having a machine that is specially designed for calorie workouts will make the losing weight process easier. You can also choose manual workouts if you do not need the calorie workout plan.. Quiet track and motor: This Sole treadmill makes a favorable machine for those that like listening to music during workout. Anyone that has used noisy treadmills knows how disturbing the sound of a loud motor can be. With the Sole F63, noisy treadmills will be your last concern. This is because its track and motor are designed to run quietly.. You can therefore keep your attention on the TV or ...
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A molecular motor that organizes the genome into distinct neighborhoods by forming loops of DNA has been characterized by researchers at MIT and the Pasteur Institute in France.
The generator set comprised a ten-pole d.c. main generator and an eight-pole d.c. overhung auxiliary generator. Maximum current for the main generator is 3,700 amp, a one hour rating is 2,700 amp, continuous current is 2,460 amp, a maximum voltage of 890V and a rated output of 1,080rpm. The auxiliary generator has a continuous output of 75kW and a steady tension of 175V. Weight for the combined set is 16,600lb with a maximum diameter of five feet, length over coupling flange is 64.4in. The six traction motors are six pole d.c. series-wound units with the drive taken up by a pinion to a resilient gear wheel on the axle. Each motor has a one hour rating of 194kW at 900amp, a continuous rating of 200kW at 820amp, a maximum starting current of 1,230 amp. Individual motor weight is 4,620lb. The reduction gears have a ration of 15:69. Force ventilation is provided, the motors are also self ventilated with a built in fan which maintains a higher pressure within the motor, preventing the ingress of dust ...
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... http://reasonandscience.heavenforum.org/t1289-molecular-machines-in-biology Biological machines: from mills to molecules 4 More th
I am looking for a taligate acutuator. - My hatchback will not close all the way. The sitch or the motor on the trucnck lid will not completely recess a...
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Kinesin motor protein, molecular model. Kinesin motor proteins transport vesicles containing intracellular cargo around the cell along microtubules. - Stock Image F009/6428
We identified axonal defects in mouse models of Alzheimers disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimers disease in humans. Axonal defects consisted of swellings that accumulated abnormal amounts of microtubule-associated and molecular motor proteins, organelles, and vesicles. Impairing axonal transport by reducing the dosage of a kinesin molecular motor protein enhanced the frequency of axonal defects and increased amyloid-β peptide levels and amyloid deposition. Reductions in microtubule-dependent transport may stimulate proteolytic processing of β-amyloid precursor protein, resulting in the development of senile plaques and Alzheimers disease. ...
Many species of bacteria actively propel themselves in a low Reynolds number environment via the rotation of one or more flagella. At the base of each flagella, you find Natures version of the rotary motor, called the Bacterial Flagellar Motor (BFM). At a diameter of 50 nm and composed of about a dozen different proteins, the BFM is able to rotate at hundreds of hertz, change direction within milliseconds, and attain very high thermodynamic efficiencies. Moreover, the motor can sense the environmental conditions and dynamically adapt its power output accordingly. This talk will introduce some of the basic physical mechanisms underlying the operation of this remarkable molecular machine which drives bacterial motility, with a particular focus on the motors ability to sense its mechanical environment.. ...
Microtubules (MT) are required for the efficient transport of membranes from the trans-Golgi and for transcytosis of vesicles from the basolateral membrane to the apical cytoplasm in polarized epithelia. MTs in these cells are primarily oriented with their plus ends basally near the Golgi and their minus-ends in the apical cytoplasm. Here we report that isolated Golgi and Golgi-enriched membranes from intestinal epithelial cells possess the actin based motor myosin-I, the MT minus-end-directed motor cytoplasmic dynein and its in vitro motility activator dynactin (p150/Glued). The Golgi can be separated into stacks, possessing features of the Golgi cisternae, and small membranes enriched in the trans-Golgi network marker TGN 38/41. Whereas myosin-I is present on all membranes in the Golgi fraction, dynein is present only on the small membrane fraction. Dynein, like myosin-I, is associated with membranes as a cytoplasmic peripheral membrane protein. Dynein and myosin-I coassociate with membranes ...
Single molecule fluorescence imaging is a powerful tool for studying protein dynamics. I have leveraged the power of single molecule imaging in studying two proteins systems: Molecular Motors and Gene Editing Proteins. Kinesin walks on cellular roads called microtubules and transports cellular cargos. Kinesin is one of the many types of molecular motors present in living cells. Generally, multiple kinesin motors are present on a single cargo during transport. Therefore, it is important to fundamentally understand how multiple motors work with each other during transport of the cargo to its destination. For understanding this, we design an in vitro assay, that we call force gliding assay. With this assay, dynamics of multiple kinesins (from 2-8) and its effect on cargo velocity can be simultaneously tracked when these kinesins transport a common cargo. Furthermore, we show that kinesins dynamically interact to overcome roadblocks. Consequently, multiple kinesins acting as a team may play a ...
The Mechanism of Motor Protein-based Force Generation. Molecular motor proteins are practically ubiquitous in cellular activities requiring movement, and mutations in motors or defects in motor regulation can have drastic effects. In order to understand the consequences of these defects, we are determining the detailed structural mechanisms employed by cytoskeletal proteins in order to 1) produce directed force along protein filaments and 2) mediate interactions with their various intra- or intermolecular protein targets. For ATP-driven molecular motors, as well as the GTP-driven G-protein family of molecular switches, conformational states are governed by the presence or absence of the nucleotideγ-phosphate. An intriguing question is how such a small conformational change can be sensed by the protein and amplified, sometimes by several orders of magnitude, in order to achieve the various cellular functions of these proteins. We are currently focusing on determining the structures of various ...
1990-1994 华东师范大学 数学. 主要研究方向:. 主要从事偏微分方程数值解、积分方程数值解、分子马达数学模型的建立与分析等相关生物物理与生物数学问题的研究。. 发表文章. 1、Properties of tug-of-war model for cargo transport by molecular motors, Yunxin Zhang Physical Review E 79, 061918 (2009). 2、Dynamics of the tug-of-war model for cellular transport, Yunxin Zhang and Michael E. Fisher Physical Review E 82, 011923 (2010). 3、Cargo transport by several motors, Yunxin Zhang, Physical Review E 83,011909 (2011). 4、Periodic one-dimensional hopping model with transitions between nonadjacent states, Yunxin Zhang, Physical Review E 84, 031104 (2011). 5、Growth and shortening of microtubules: a two-state model approach, Yunxin Zhang, The Journal of Biological Chemistry 286(2011), 39439-39449.. ...
To see if the motor can be arrested in a particular configuration by the help of a ligand, so that it becomes dysfunctional and inhibits cell division leading to apoptosis.
Get an in-depth review and ask questions about Ron Vale (UCSF/HHMI): Molecular Motor Search - Myosin to Kinesin. See what people are saying about Ron Vale (UCSF/HHMI): Molecular Motor Search - Myosin to Kinesin.
Discover what controls how fast tiny molecular motors in our body pull through a single strand of DNA. How hard can the motor pull in a tug of war with the optical tweezers? Discover what helps it pull harder. Do all molecular motors behave the same?
Fahrner, K.A. and Berg, H.C. Mutations that stimulate flhDC expression in Escherichia coli K-12. J. Bacteriol. 197 No.19, 3087-3096 (2015).. Yuan, J., Fahrner, K.A., Turner, L., and Berg, H.C. Asymmetry in the clockwise and counter-clockwise rotation of the bacterial flagellar motor. Proc. Natl. Acad. Sci. USA 107, 12846-12849 (2010).. Yuan, J., Fahrner, K. A. & Berg, H. C. Switching of the bacterial flagellar motor near zero load. J. Mol. Biol. 390, 394-400 (2009). Bates, D., Epstein, J., Boyle, E., Fahrner, K., Berg, H. and Kleckner, N. The Escherichia coli baby cell column: a novel cell synchronization method provides new insight into the bacterial cell cycle. Molec. Microbiol. 57, 380-391 (2005). Fahrner, K.A., Ryu, W.S. and Berg, H.C. Bacterial flagellar switching under load. Nature 423, 938 (2003). Scharf, B.E., Fahrner, K.A. and Berg, H.C. CheZ has no effect on flagellar motors activated by CheY13DK106YW. J. Bacteriol. 180, 5123-5128 (1998). Fahrner, K.A., Block, S.M., Krishnaswamy, S., ...
Empowered by a $1.2 million grant from the National Institutes of Health (NIH), Arizona State University scientist Wayne Frasch is deciphering how one of the world’s smallest molecular motors works in living cells. In ...
Understanding how tiny molecular motors called myosins use energy to fuel biological tasks like contracting muscles could lead to therapies for muscle diseases and cancers, says a team of researchers led by Penn State College of Medicine scientists.
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Our goal is to understand how kinesin motors function in live cells, that is, in the presence of relevant cargo and regulatory proteins and under the physical and physiological constraints of the cytoplasm. We use a variety of methods, from biophysical to cell biological, to investigate kinesin motors from the single molecule to the cellular level. Relevant questions include: How do kinesin motors bind their cargoes and become activated for transport? How do kinesin motors navigate the complex microtubule network in cells? How do multiple motors on the surface of a cargo coordinate their activities ...