Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent; however, whether lncRNAs play roles in cancer resistance in this seductive species remains unknown. In this study, we developed a pipeline and identified a total of 4422 lncRNAs across the NMR genome based on 12 published transcriptomes. Systematic analysis revealed that NMR lncRNAs share many common characteristics with other vertebrate species, such as tissue specificity and low expression. BLASTN against with 1057 human cancer-related lncRNAs showed that only 5 NMR lncRNAs displayed homology, demonstrating the low sequence conservation between NMR lncRNAs and human cancer-related lncRNAs. Further correlation analysis of lncRNAs and protein-coding genes indicated that a total of 1295 lncRNAs were intensively

TY - JOUR. T1 - Temperature changes during pregnancy in the subterranean naked mole-rat (Heterocephalus glaber) ; the role of altered body composition and basking behaviour. AU - Buffenstein, R.. AU - Urison, N. T.. AU - Woodley, R.. AU - Van Der Westhuizen, L. A.. AU - Jarvis, Jum. PY - 1996/12/1. Y1 - 1996/12/1. N2 - Naked mole-rats exhibit pronounced thermolability, with body temperature closely tracking that of ambient. We questioned whether this pattern would be maintained with pregnancy. Body mass, body composition, rectal temperature and basking behaviour of breeding females and their mates were monitored in early (weeks 1-3), mid (weeks 4-7) and late (weeks 8-10) pregnancy. All these variables increased significantly in mid and late pregnancy compared to non pregnant and early pregnant values. Body mass increments (25.8 ± 2.74 %), coupled with increased percentage body fat (31.9 ± 2.05 %) may contribute to the elevated body temperature during pregnancy. The increased mass leads to a ...

Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have found out why the African naked mole-rat (Heterocephalus glaber), one of the world´s most unusual mammals, feels no pain when exposed to acid. African naked mole-rats live densely packed in narrow dark burrows where ambient carbon dioxide (CO2) levels are very high. In body tissues, CO2 is converted into acid, which continuously activates pain sensors. However, naked mole-rats are an exception: they have an altered ion channel in their pain receptors that is inactivated by acid and makes the animals insensitive to this type of pain. Dr. Ewan St. John Smith and Professor Gary Lewin conclude that this pain insensitivity is due to the African mole-rats´ adaptation to their extreme habitat over the course of evolution (Science , Vol. 334, Dec.16, 2011, 1557-1560)*.. The Nav1.7 sodium ion channel plays a key role in the transmission of painful stimuli to the brain. It triggers a nerve impulse (action potential) ...

Most superheroes dont get to bask in the glory of recognition from their communities; many live double lives, of course, or the public simply misunderstands their motivations. Batman doesnt get the keys to Gotham. Spider-Man doesnt always get a heros welcome in New York.. But the amazing naked mole rat (Heterocephalus glaber) -- an animal with a superpower immune system -- was named Vertebrate of the Year in 2013 by Science magazine. Now dont be too outraged you lost out to a mouse-sized, hairless, bucktoothed competitor. These unnerving-looking creatures very much deserve the honor.. Thats because instead of immunity to radiation or injury, the naked mole rat seems to be immune to cancer [source: Poppick]. And their superpower makes them a boon to scientists desperate to know more about the disease and how it affects humans. Theyve already discovered that mole rats have a peculiarly heavy form of the substance hyaluronon between tissues that seems to impede the creation of tumors, and ...

Naked but far from vulnerable, the African naked mole-rat is an unusual mammal that is unique because it is impervious to painful chemicals that cause severe pain in all other species studied.

THURSDAY, April 20, 2017 (HealthDay News) -- When brain cells are starved of oxygen, people and all other mammals run out of energy and begin to die.. Not so for a hairless, underground rodent called the naked mole-rat. It survives low-oxygen conditions because its brain cells switch from using glucose as fuel to fructose -- a process that is typically found in plants, not animals.. Scientists believe their new findings could someday lead to new treatments for people who have a heart attack or stroke.. This is just the latest remarkable discovery about the naked mole-rat -- a cold-blooded mammal that lives decades longer than other rodents, rarely gets cancer and doesnt feel many types of pain, said the studys leader, Thomas Park. He is a professor of biological sciences at the University of Illinois at Chicago.. The naked mole-rat is native to Africa and lives in extensive underground burrows. In the latest research on these remarkable creatures, Park and his colleagues found that naked ...

The naked mole rat is an example of neoteny (pronounced nēŏtˈnē)- prolonged youthfulness. As biologists describe them in a report published in Physiology Reviews, old naked mole rats do not become covered with wrinkles, participate in procreation throughout life, and their survivorship does not dramatically decrease with advancing age. Here, here!. Naked mole rats are said to live in a vivarium. Bees and ants have queens that live longer than their subordinates, but in the case of naked mole rats, the entire cohort lives longer.. The brain of naked mole rats is resistant to oxygen deprivation, thus maintaining youthful mental faculties. Old naked mole rat brains have juvenile characteristics.. The NMR has a longer maturation period than other rodents which helps to maintain elastic blood vessels, bone density and muscle mass.. The fact that the numbers of mitochondria (energy producing compartments) in the cells of NMRs increases from 4.8% at age 6 months to 12.7% at age 5 years suggests ...

This species is eusocial-one female leads the colony, which is primarily composed of male and female workers. A normal colony contains about 70 members. As individuals rarely leave their group, inbreeding is common, resulting in genetically similar colony members.. The burrows in which naked mole rats live are complex. Tunnels link chambers dedicated as nests, toilets and pantries. Subsisting on the underground parts of plants, naked mole rats dont need to drink water, since this food supply is moist. ...

Domain architecture and assignment details (superfamily, family, region, evalue) for HGL_H00000288221 from Heterocephalus glaber v1.7-2. Plus protein sequence and external database links.

Domain architecture and assignment details (superfamily, family, region, evalue) for HGL_H00000316030 from Heterocephalus glaber v1.7-2. Plus protein sequence and external database links.

We have studied sperm structure and motility in a eusocial rodent where reproduction is typically restricted to a single male and behaviourally dominant queen. Males rarely compete for access to the queen during her estrus cycle, suggesting little or no role for sperm competition. Our results revealed an atypical mammalian sperm structure with spermatozoa from breeding, subordinate and disperser males being degenerate and almost completely lacking a mammalian phylogenetic stamp. Sperm structure is characterized by extreme polymorphism with most spermatozoa classified as abnormal. Sperm head shapes include round, oval, elongated, lobed, asymmetrical and amorphous. At the ultrastructural level, the sperm head contains condensed to granular chromatin with large open spaces between the chromatin. Nuclear chromatin seems disorganized since chromatin condensation is irregular and extremely inconsistent. The acrosome forms a cap (ca 35%) over the anterior part of the head. A well defined nuclear fossa and

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

nearly 20 minutes. As a consequence of sharing tight, cramped quarters with up to 200 others in subterranean colonies, naked mole rats have adapted to a life in which oxygen levels are frequently low by developing a fructose-based metabolic system. This process doesnt require oxygen to perform, and was previously believed to only be used by plants.. The study, co-led by Gary Lewin of the Max Delbrück Center for Molecular Medicine, systematically tested just how much of a lack of oxygen these little rodents could withstand. For all known mammals, the cells of the brain begin to starve as soon as it becomes deprived of oxygen, which then depletes the mammals of their energy and causes them to die. In this experiment, researchers placed the subjects in an environment with only five percent oxygen, or half the amount required to keep a human being alive. After several hours in these conditions, researchers found that the mole rats were hardly affected at all. The researchers then proceeded to ...

Mole rats are a pretty ugly, obscure bunch of creatures. They live underground in Africa, where they use their giant teeth to gnaw at roots. Those of you who know anything about mole rats most likely know about naked mole rats, which have evolved a remarkable society that is more insect than mammalian, complete with a queen mole rat ruling over her colony. But according to a paper in press at the Journal of Human Evolution, mole rats are important for another reason.

Naked mole rats live decades longer than other rodents, resist getting cancer and are impervious to certain types of pain. Each colony has a female queen that gives birth to young, a small number of breeding males, and numerous sterile workers.. Lead scientist Professor Thomas Park, from the University of Illinois in Chicago, US, said: The naked mole rat has simply rearranged some basic building-blocks of metabolism to make it super-tolerant to low oxygen conditions.. In laboratory tests, naked mole rats totally starved of oxygen went into a state of suspended animation but survived for up to 18 minutes with no lasting ill effects. ...

Immune to acids, toxins and heavy metals. Doesnt feel pain. Never gets cancer. Stays young forever. Lives 9 times longer than its peer. Oh, and naked all the time. No wonder the naked mole rats is considered the "underground supermodel" by The Scientist magazine. Naked mole-rats, unlike other mammals, tolerate variable body temperatures, attributed to their lack of an insulatory layer of fur. Their pink skin is hairless except for sparse, whisker-like strands that crisscross the body to form a...

Exp Gerontol. 2007 Nov;42(11):1053-62. Comparative Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt

Compared to the average three year life span of a common rat, the 10 to 30 year life of the naked mole rat, a subterranean rodent native to East Africa, is impressive. And compared to the human body, the body of this rodent ...

Avivi, A.; Oster, H.; Joel, A.; Beiles, A.; Albrecht, U.; Nevo, E.: Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi superspecies. Proceedings of the National Academy of Sciences of the United States of America 99 (18), S. 11718 - 11723 (2002 ...

Scientists have sequenced the genome of the naked mole rat, a highly social underground rodent of extraordinary longevity that retains youthful biology, good health and fertility well into...

Naked mole rats and humans are odd compared to most mammals. Those oddities may explain a lot about modern human diseases. The biggest difference between humans and NMRs is the control of blood glucose. It seems that NMRs control their metabolism by their eating. In times of starvation, the NMRs eat less and their metabolic rate lowers. At the cellular level, this must mean that fat stores are converted to blood glucose to modestly regulate blood sugar as it drops, but the lack of insulin does not permit control of high blood sugar. Thus, a rise in blood sugar must lead to cessation of eating. This would make sense, because NMRs husband their resources -- they typically encounter few, very large, starchy, underground tubers/roots, eat into them and continue to live off of them for their lifetimes. They are underground farmers. They do not wolf down their slow moving prey and hunt for more ...

Naked Mole Rats live in colonies like bees, crowning a Queen who runs the show. The Smithsonian National Zoo crowns its colonys newest monarch.

Heres the kicker:. Unlike us, naked mole rats live their entire lives underground and so they dont have the sun as a visual cue and yet they have a really strong circadian rhythm. Their longevity and resistance to disease are therefore of great interest.. We all have this internal bio clock, says Dr Helfer. All living things have it, from plants to humans, even bacteria. It means you wake up in the morning and go to sleep at night. Even before you wake up, certain hormones are released by your body. So, your blood pressure goes up, the sleep hormone melatonin, which comes from your pineal gland, is shut down, your breathing becomes faster, your heartbeat picks up. All of this is governed by your circadian rhythm.. In fact, as Dr Helfer explains, every function of the body has its own specific time and when we deviate from these, things start to go wrong in other ways.. Put simply, the body cannot do everything at once. If we have a good rhythm, we are in good health. If for any reason ...

While most mammals thrive on oxygen-rich air, naked mole rats prefer the carbon dioxide (CO2)-rich environment of their underground nest.

The naked mole rat is a bizarre rodent that spends its entire life span in underground tunnels, due to which its body and looks have undergone drastic changes.

Naked mole rats flip a metabolic switch to last for hours in oxygen levels that would kill other mammals. They can last 18 minutes with zero oxygen.

For any other animal, sperm like the naked mole rat's would be considered faulty and infertile: Only about 0.1 percent of the sperm are fast, active swimmers. A lack of competition for mating (because only three to four chosen males mate with the queen of

Lists of the world's ugliest animals sometimes include the naked mole rat. But scientists who have just analyzed its entire genetic code say this

Damaraland mole rats (Fukomys damarensis) are cooperatively breeding, subterranean mammals, which exhibit high reproductive skew. Reproduction is monopolized by the dominant female of the group while subordinates are physiologically suppressed to the extent that they are anovulatory. It is thought that in these latter animals normal GnRH secretion from the hypothalamus is disrupted. The RFamide peptides kisspeptin (Kiss1) and RFamid-related peptide-3 (RFRP-3) are considered potent regulators of gonadotropin release. To assess whether these neuropeptides are involved in the mechanism of reproductive suppression we investigated the distribution and gene expression of Kiss1 and Rfrp by means of in situ hybridisation in wild-caught female Damaraland mole-rats with different reproductive status. In both reproductive phenotypes, substantial Kiss1 expression was found in the arcuate nucleus and only few Kiss1-expressing cells were detected in the AVPV, potentially due to low circulating estradiol ...

ID G5BDR1_HETGA Unreviewed; 869 AA. AC G5BDR1; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 25-OCT-2017, entry version 33. DE SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313,EMBL:EHB07422.1}; GN ORFNames=GW7_12560 {ECO:0000313,EMBL:EHB07422.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313,EMBL:EHB07422.1, ECO:0000313,Proteomes:UP000006813}; RN [1] {ECO:0000313,EMBL:EHB07422.1, ECO:0000313,Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun ...

ID G5BHH7_HETGA Unreviewed; 113 AA. AC G5BHH7; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 25-OCT-2017, entry version 13. DE SubName: Full=Eukaryotic translation initiation factor 1 {ECO:0000313,EMBL:EHB08738.1}; GN ORFNames=GW7_08780 {ECO:0000313,EMBL:EHB08738.1}; OS Heterocephalus glaber (Naked mole rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; OC Hystricomorpha; Bathyergidae; Heterocephalus. OX NCBI_TaxID=10181 {ECO:0000313,EMBL:EHB08738.1, ECO:0000313,Proteomes:UP000006813}; RN [1] {ECO:0000313,EMBL:EHB08738.1, ECO:0000313,Proteomes:UP000006813} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=21993625; DOI=10.1038/nature10533; RA Kim E.B., Fang X., Fushan A.A., Huang Z., Lobanov A.V., Han L., RA Marino S.M., Sun X., Turanov A.A., Yang P., Yim S.H., Zhao X., RA Kasaikina M.V., Stoletzki N., Peng C., Polak P., Xiong Z., Kiezun A., RA Zhu Y., Chen Y., ...

Oxidative stress is reputed to be a significant contributor to the aging process and a key factor affecting species longevity. The tremendous natural variation in maximum species lifespan may be due to interspecific differences in reactive oxygen species generation, antioxidant defenses and/or level …

The form of HA made by naked mole rats has a much longer, more complex molecule than the HA we and other rodents produce. The naked mole rats also produce it in higher concentrations than we do. Scientists studying them believe that the high concentration of HA evolved in naked mole rats to keep their bare skin stretchy so they can move easily within their underground tunnels, and the cancer resistance it also had was a great side-benefit ...

Contact inhibition, a powerful anticancer mechanism, discovered by the Rochester team, arresting cell growth when cells come into contact with each other, is lost in cancer cells, explains Prof. Eviatar Nevo, from the Institute of Evolution at the University of Haifa, The experiments showed that when HMM-HA was removed from naked mole rat cells, they became susceptible to tumors and lost their contact inhibition. HMM-HA is a form of Hyaluronan- a long sugar polymer, naturally present as a lubricant in the extracellular matrix of the human body. It is commonly used in the treatment of arthritis or in anti-wrinkle skin care products. According to the current results, the naked mole rat cells secrete extremely high-molecular mass HA, which is over five times larger than human or mouse HA. This high-molecular-mass HA accumulates abundantly in naked mole rat tissues, owing to a more robust synthesis by a protein called HAS2 and a decreased activity of HA-degrading enzymes.. When researchers ...

Image of a naked mole rat By Roman Klementschitz, Wien - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=252701 Researchers trying to find cures for cancer find naked mole rats rather interesting. Not only are these animals long-lived by rodent standards, they are also resistant to the development of cancer. By long-lived, we are talking up to 30 years! A team of researchers from Hokkaido University and Keio University in Japan have now isolated stem cells from the skin of naked mole rats and induced them to revert back to pluripotent stem cells, the type capable of… ...

The genome sequence of the naked mole rat is published recently (Kim et al., 2011) ! This is an amazing creature that lives almost up to 30 years in captivity, 9 times longer than mice. At the same time they do not seem to suffer from cancer or a decline in fertility (Buffenstein 2008).. I have been fascinated by the research on the naked mole rats since I read an research article published by Vera Gorbunovas group in 2009 (Seluanov et al., 2009). In this study, the authors elucidated the naturally occurred anti-cancer mechanism inside this creature. As it turns out, the cells from the naked mole rat will initiate a program to turn off cell growth as soon as the cells start touching each other in culture, a much earlier response than that in regular rats or mice. The most impressive finding is that this early program that can turn off cell growth actually uses the same cell division control mechanisms as in us, but it is just fine-tuned to respond to growth more sensitively. In the new study ...

|span||i|Homo sapiens|/i| and naked mole rats (|i|Heterocephalus glaber|/i|) are vivid examples of social mammals that differ from their relatives in particular by an increased lifespan and a large number of neotenic features. An important fact for biogerontology is that the mortality rate of |i|H. glaber|/i||/span| …

Abstract. Accepted 16th January, 2015. Dendritic cells (DC) are strong antigen secreting cells (ASC) collecting antigens by taking them from the tissues, carrying them to the lymph nodes and giving them to T cells in order that they could obtain immunity. They are called as melanocytes, Langerhans cells and epidermal dendritic cells in the literature of dermatology. These cells are placed as suprabasal in the mole rats dermis having a deep notched nucleus with a great number of mitochondria and small vesicles in their cytoplasm. Since they do not have tonofibrils and desmosomes in their structure, they can be separated very easily from keratinocytes and the other cells. These cells do not have any membrane contact with basal membranes and neighboring keratinocytes. Dendritic cells are surrounded by neighboring keratinocytes tightly, having a character of open cytoplasm (light cell). In the epidermis of mole rats, Langerhans cells and dendritic cells were rarely observed, while no melanocyte and ...

Mole rats, including the naked mole rat, live in underground colonies. The majority of rodents in the colonies are workers, with only one female (the queen) and one male responsible for breeding. All individuals cooperate by digging large underground tunnel systems to forage for food, and if a large food source is found, it is shared with the entire colony. Queens and reproductive males remain in this role for their entire life after they have achieved this position.

He probably had very distant familial connections to the Claudianclan. Gaius Claudius Glaber était un préteur romain du Ier siècle av. Arduin Glaber (died c. 977), the Count of Auriate from c. 935 and Margrave of Turin from c. 950; Gaius Claudius Glaber, a Roman praetor in 73 BC. J.-C.), Date de décès non renseignée (Ier siècle av. A militia was sent under the leadership of praetor Gaius Claudius Glaber … In 73 BC, Spartacus began his rebellion against the republic, and her father was the first commander to be sent to defeat him. Gaius Claudius Glaber is a Roman commander awarded the title of Legatus, and later Praetor. Found hiding behind curtains in the palace, shaking with fright, when Caligula was murdered in AD 41, he was made emperor by the Praetorian Guard. He was defeated in the battle of Mount Vesuvius against the forces of Spartacus during the Third Servile War. Gertrude, Hamlets mother drinks some of it by mistake and dies. Envoyé par le Sénat pour mater la révolte, il ...

In insect societies, only one to few individuals members of a colony can reproduce, whereas the other colony members have their reproductive capabilities suppressed. This conflict over reproduction in some cases results in a dominance hierarchy. Dominant individuals in this case are known as queens and have the obvious advantage of performing reproduction and benefiting from all the tasks performed by their subordinates, the worker caste (foraging, nest maintenance, nest defense, brood care and thermal regulation). According to Hamiltons rule, the reproduction costs of the worker caste are compensated by the contribution of workers to the queens reproductive success, with which they share genes. This is true not only to the popular social insects (ants, termites, some bees and wasps), but also for the naked mole-rat Heterocephalus glaber. In a laboratory experiment, Clarke and Faulkes (1997)[18] demonstrated that reproductive status in a colony of H. glaber was correlated with the individuals ...

The pink, hairless subterranean mammal is insensible to pain caused by acid. Now we know why, which could lead to treatments for arthritis

The naked mole-rat is native to the deserts of East Africa and has unique physical traits that allow it to survive in harsh environments for many years. It has a lack of pain sensation in its skin and has a low metabolic rate that allows it to live underground with limited oxygen supply.. For the first time, scientists, in partnership with The Genome Analysis Centre (TGAC), Norwich, which receives strategic funding from BBSRC, have sequenced the genome of the naked mole-rat to understand its longevity and resistance to diseases of ageing. Researchers will use the genomic information to study the mechanisms thought to protect against the causes of ageing, such as DNA repair and genes associated with these processes.. To date, cancer has not been detected in the naked mole-rat. Recent studies have suggested that its cells possess anti-tumour capabilities that are not present in other rodents or in humans. Researchers at Liverpool are analysing the genomic data and making it available to ...

The naked mole-rat is native to the deserts of East Africa and has unique physical traits that allow it to survive in harsh environments for many years. It has a lack of pain sensation in its skin and has a low metabolic rate that allows it to live underground with limited oxygen supply. For the first time, scientists from the University of Liverpool and The Genome Analysis Centre (TGAC) in Norwich, UK, have sequenced the genome of the naked mole-rat to understand its longevity and resistance to diseases of aging. Researchers will use the genomic information to study the mechanisms thought to protect against the causes of aging, such as DNA repair and genes associated with these processes. To date, cancer has not been detected in the naked mole-rat. Recent studies have suggested that its cells possess anti-tumor capabilities that are not present in other rodents or in humans. Researchers at Liverpool are analyzing the genomic data and making it available to researchers in health sciences, ...

The papers detailed below were judged by the editors of Aging Cell to merit the Aging Cell Runner-Up Best Paper Prize 2010. This Prize is awarded by the Anatomical Societys Prizes and Awards Committee, on the recommendation of the Editors-in-Chief of Aging Cell.. The annual prize for the best paper published in the journal Aging Cell in 2010 (Volume 9) has been awarded to Dr. Chen-Yu Liao and co-authors for their paper describing the Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.. PAPER 9(4) 626-635. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)Sitai Liang, James Mele, Yuehong Wu, Rochelle Buffenstein and Peter J. Hornsby PAPER 9(2) 162-173. SIRT6 protects against pathological damage caused by diet-induced obesityYariv Kanfi, Victoria Peshti, Reuven Gil, Shoshana Naiman, Liat Nahum, Eran Levin, Noga Kronfeld-Schor and Haim Y. Cohen. ...

Its difficult to find an odder animal than the naked mole rat (Heterosphalus glaber). A native of east African deserts, these mammals live more like bees, in complex, underground societies complete with a queen who gives birth to worker offspring who will never reproduce. Also, unlike other mammals, they dont regulate their body temperatures and so are essentially cold blooded, like reptiles.. In recent years, scientists have come to learn more and more about these curious creatures. Theyve discovered that theyre oblivious to most types of pain, are pretty much cancer resistant, and can live for up to 32 years under the right conditions. Contrast this to the average three-year lifespan for most other rodents, many of which are ideal subjects for study precisely because they do contract cancer readily. Its easy to see why the naked mole rat has gained popularity among scientists hoping to find ways to improve the quality of life as humans age. Recently, however, scientists have uncovered ...

Deprived of oxygen, naked mole-rats can survive by metabolizing fructose just as plants do, researchers report this week in the journal Science -- a finding that could lead to treatments for heart attacks and strokes.

Looking for online definition of Naked mole-rats in the Medical Dictionary? Naked mole-rats explanation free. What is Naked mole-rats? Meaning of Naked mole-rats medical term. What does Naked mole-rats mean?

African naked mole-rats are eusocial mammals that provide unique opportunity to study complex mammalian social behavior and large-group dynamics in a controlled vivarium setting. Previous reports of captive and wild naked mole-rats have identified a division of labor among non-reproductive colony members along a size polyethism, with large animals specializing in defense behaviors, and small animals performing foraging, nest building, and caretaking functions. This study utilized radio frequency identification (RFID) and advanced computational approaches to monitor the activity patterns and place preferences of all members in two naked mole-rat colonies (N = 36 and 37 animals) for a period of 26 days. Results demonstrated colony differences in- and therefore suggested social regulation of- patterns of colony behavior. Mapped onto different colony rhythms were more universal rules for space preferences depending upon the size and role of the individual: the Queen/Male breeders and the large workers spent

Blind mole rats dont get cancer, and geneticists have worked out why: Their cells kill themselves with a poisonous protein when they multiply too much.

389692 Homo sapiens , 114467 Danio rerio , 366949 Rattus norvegicus , 378435 Mus musculus , 395881 Gallus gallus , 613050 Xenopus tropicalis , 618421 Bos taurus , 746440 Pan troglodytes , 100017161 Monodelphis domestica , 100229012 Taeniopygia guttata , 100541507 Meleagris gallopavo , 100627724 Sus scrofa , 100684427 Canis lupus familiaris , 100709735 Oreochromis niloticus , 100733756 Cavia porcellus , 100952055 Otolemur garnettii , 101010868 Papio anubis , 101073048 Takifugu rubripes , 101127290 Gorilla gorilla , 101163404 Oryzias latipes , 101282283 Orcinus orca , 101383866 Odobenus rosmarus divergens , 101443589 Dasypus novemcinctus , 101476520 Maylandia zebra , 101589053 Octodon degus , 101593787 Jaculus jaculus , 101725333 Heterocephalus glaber , 101820211 Ficedula albicollis , 101833897 Mesocricetus auratus , 101918104 Falco peregrinus , 101953602 Chrysemys picta , 101965478 Ictidomys tridecemlineatus , 101987687 Microtus ochrogaster , 102030596 Chinchilla lanigera , 102040178 Geospiza ...

11067 Homo sapiens , 477754 Canis lupus familiaris , 500300 Rattus norvegicus , 613715 Bos taurus , 706321 Macaca mulatta , 100172435 Pongo abelii , 100349113 Oryctolagus cuniculus , 100406835 Callithrix jacchus , 100469209 Ailuropoda melanoleuca , 100583078 Nomascus leucogenys , 100621791 Sus scrofa , 100758614 Cricetulus griseus , 100945072 Otolemur garnettii , 100976675 Pan paniscus , 101026002 Papio anubis , 101048536 Saimiri boliviensis , 101098991 Felis catus , 101120888 Ovis aries , 101127049 Gorilla gorilla , 101283291 Orcinus orca , 101322569 Tursiops truncatus , 101380194 Odobenus rosmarus divergens , 101427926 Dasypus novemcinctus , 101549181 Sorex araneus , 101600231 Jaculus jaculus , 101689972 Mustela putorius furo , 101712652 Heterocephalus glaber , 101789284 Cavia porcellus , 101839178 Mesocricetus auratus , 101936316 Chrysemys picta , 101969412 Ictidomys tridecemlineatus , 102002793 Microtus ochrogaster , 102013551 Chinchilla lanigera , 102127452 Macaca fascicularis , 102150502 ...

TY - JOUR. T1 - Gradient-consistent non-linear model of the generation of ultrasound in the propagation of seismic waves. AU - Krylov, A. L.. AU - Mazur, N. G.. AU - Nikolayevskii, V. N.. AU - El, G. A.. PY - 1993. Y1 - 1993. N2 - The equations of the propagation of weak non-linear waves are obtained by a detailed analysis of the gradient-consistent micropolar model of a granular continuous medium. The high-frequency mode of oscillation is associated with ultrasonic waves, and the low-frequency mode is associated with the usual seismic waves in rocks. The evolution equations that include the case of long-wave-short-wave resonance are obtained by an asymptotic consideration. This resonance corresponds to the case of the generation of ultrasound (noise) by travelling seismic waves.. AB - The equations of the propagation of weak non-linear waves are obtained by a detailed analysis of the gradient-consistent micropolar model of a granular continuous medium. The high-frequency mode of oscillation is ...

The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and ...

Science Magazine has given the east African naked mole rat its coveted Vertebrate of the Year award. Perhaps it was presumptuous of us to think intelligence, cunning and near nakedness would gain humans the top ranking-not to mention keeping Homo sapiens atop the food chain.But University of Rochester biologists Vera Gorbunova and Andrei Seluanov offered a powerful rationale for the magazines judges to summon up the backbone to give the nod to the bucktoothed, hairless rodents, who spend their entire lives underground. They live their 30-year lifespans in near perfect health and never get cancer.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, et al., Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nature Communications, 5:3966. doi: 10.1038/ncomms4966, ...

Aging is the greatest risk factor for developing neurodegenerative diseases, which are associated with diminished neurotransmission as well as neuronal structure and function. However, several traits seemingly evolved to avert or delay age-related deterioration in the brain of the longest-lived rodent, the naked mole-rat (NMR). The NMR remarkably also exhibits negligible senescence, maintaining an extended healthspan for ~75 % of its life span. Using a proteomic approach, statistically significant changes with age in expression and/or phosphorylation levels of proteins associated with neurite outgrowth and neurotransmission were identified in the brain of the NMR and include: cofilin-1; collapsin response mediator protein 2; actin depolymerizing factor; spectrin alpha chain; septin-7; syntaxin-binding protein 1; synapsin-2 isoform IIB; and dynamin 1 ...

Neuropeptides are a diverse assemblage of signalling molecules that have key roles in the regulation of behaviour. Understanding the evolutionary relationships and functions of the plethora of neuropeptides has presented a considerable challenge to biologists. Based on presentations and discussions at a Royal Society meeting in 2017, three companion Review articles by Elphick et al., Jékely et al. and DeLaney et al. discuss advances in our knowledge of neuropeptide evolution and function and the techniques that have facilitated progress in this field of research.. ...

This species is endemic to South Africa. Ranges from the Cape Peninsula (Western Cape) south-eastwards across Cape Flats to Bredasdorp, Swellendam, possibly as far as Knysna; and northwards along the Atlantic coast to Port Nolloth in Northern Cape. Occurs inland to Ceres, Worcester, Sutherland and Stellenbosch in the south, and Calvinia, Garies and Kamieskroon in the north, but does not penetrate the arid Karoo. One specimen (type of C. damarensis) recorded from Damaraland in Namibia is probably a misidentified specimen from Little Namaqualand (Meester et al. 1986). ...

Carl Zimmer has a good post up which comments on a new paper (full text) by Greg Laden and Richard Wrangham which elaborates the thesis that hominids survived on the savanna in large part by consumption of tubers. The funniest aspect, which Carl highlights, is the correlation between mole rat and homonid remains (mole rats consume tubers).1 Anyway, great paper, historical science at its best, marshalling multiple points of evidence which converge on one hypothesis. I am waiting for John Hawks response because I would like him to comment on the feasibility of using carbon isotopes to infer the diet of hominids (he has expressed skepticism before ...

Define Zemni. Zemni synonyms, Zemni pronunciation, Zemni translation, English dictionary definition of Zemni. n. 1. The blind mole rat , native of Eastern Europe and Asia. Its eyes and ears are rudimentary, and its fur is soft and brownish, more or less tinged with...

Scurry into the Small Mammal House, and meet more than 35 species as they move, eat and play in enclosures that mimic their wild habitats. Sand cats dwell in desert landscapes, golden lion tamarins jump from tree to tree and naked mole-rats tunnel through tubes.

ANDREA WOO - LAS VEGAS It is late afternoon on a sweltering day, and a group of doctors at the University Medical Center of Southern Nevada has gathered around the body of a teenage boy. His accidental death days earlier cut short a life of potential - but his parents decision to donate his organs is giving…

This Photo Gallery is closed please visit our new Media Gallery with all of this content and more at http://www.africahunting.com/media/ ...

Fallout Shelter menawarkan sensasi permainan yang berbeda. Oleh karena dunia telah hancur dan kacau akibat peperangan serta serangan nuklir, orang-orang mulai berpikir untuk membangun kehidupan dan komunitas di bawah tanah. Dalam permainan ini, kita diajak untuk bertindak sebagai Valut Overseer yang bertugas untuk membuat para Dwellers tetap bahagia. Juga menjaga para Dwellers dari serangan Radroach, Mole Rats, Deathclaws dan Raiders ...

The new study could help researchers better differentiate underground nuclear tests from earthquakes, mine collapses, mine blasts and other events that generate seismic waves.. UC Berkeley graduate student and LLNL Lawrence Scholar Sean Ford was able to quickly collect the data from the Crandall Canyon seismograms at the time and plug it into the Laboratory algorithm that pointed to a collapse rather than an earthquake.. These results were posted within a few days after the event and were helpful in resolving the source of the magnitude 3.9 seismic signal, Ford said.. The new technique compares model seismograms to the observed seismograms at local to regional distances (0-1,500 kilometers) at intermediate periods (five to 50 seconds).. Another notable fact about the collapse: The team detected Love waves (also named Q waves - surface seismic waves that cause horizontal shifting of the earth). Typically small in instances such as large mine collapses or hole collapses that sometimes follow ...

Physicist and blogger Rhett Allain measures the speed of the East Coast earthquake on Aug. 23 compared to the tweet wave that occurred simultaneously.

Love when you seek shelter in a place full of threat The personal shift between dreams, hope, longing and reality is captured in a personal love curve sketched as a seismic wave in Shiva Anoshirvanis piece Kärlek, När du söker skydd I en plats full av hot. The love curve, is a set of rhythmic markings, reflecting the timeline from her birth until present day. Here memory is condensed into abstract lines, which we view as a reading of earthly eruptions. Are these peaks of elastic shock waves moments of joy or sadness, passion or grief? Shiva does not expose what they are but visually we can feel the physical impacts through the reading of the seismic wave.. Text by Roberto Ekholm ...

Prof. of Research - Personal WebsiteWatch the movie : The Israeli Subterranean Blind Mole-rat: A Promising Organism for Fighting Cancer in HumansBetter check that mole: Has an Israeli biologist found the key to curing cancer? Article from Haaretz MagazineProf. Aaron Avivi (center) with Drs Imad ...

NOTES: Range status: NORMAL; Breeding status: UNKNOWN; Frequency of sound: NORMAL; General climate: HUMID; Cover density: THICK; 1 ADULT(S); Sex: UNKNOWN. ...

The fertility doctor who Nadya Suleman claimed helped her conceive her brood of 14 has been formally accused of negligence and violation of professional guidelines by the California Medical Board. The state licensing body said Monday that Beverly Hills fertility doctor Michael Kamrava acted beyond the reasonable judgment of any treating physician by repeatedly providing fertility treatment to a woman identified in the complaint only by the initials N.S.. Suleman has previously identified Kamrava as her doctor. The document says his patient became pregnant with octuplets. Suleman gave birth to the worlds longest-living set of octuplets on Jan. 26, 2009. She already had six other children. Kamrava is accused of gross negligence in three instances: transferring too many embryos, repeatedly transferring fresh embryos when frozen ones were available, and failing to refer Suleman for a mental health evaluation. Kamrava is also accused of giving Suleman too much of a hormone while stimulating in ...

Healthcare in Europe has been a flag-bearer in developing new drugs and medical care to create the worlds healthiest and longest-living society. But it comes at huge cost to public funds. Countries throughout the European Union are now looking at new ways of reforming the way healthcare is provided and run. Harmonising healthcare across EU countries is one way whi...

668 Index `Fallow Years, -MB 456 Plate XLVII; Galtons love of sketching, I 94, 95, 132, 133, 135; sketches by Galton, of Bishops Gateway at Liege, I 94 Plate XLIX, of his rooms at Trinity College, I 150 Plate LI, IIIB 453 Plate XLIII, of Ely Cathedral and of Kings College Chapel, I 167 Plate - LII, of last meeting, of Caseo-Tostic Club, I 181 Plate LIV, of Emma Galton and Julia Hallam, I 180 Plate LIII, of corona and brushes, of total eclipse in Spain, 11 910; from Galtons Egyptian sketchbook, Bob and Ibrahim, IIIB 454 Plate XLIV, of Ali from Galtons Syrian sketchbook, IIIB 454 Plate XLV; from Galtons South African Diaries, Nangoro, I : 59 Plate XXXVIII, 1237 Plate LVIII, Ovampos and Omutchikota (Otchikoto?), I 216 Plate LVII, of lion-trap and pencil snapshots, I 215 Plate LVI, of Jonker. Afrikaner walking off with Galtons code of `laws, 1226 Plate LVIII, of Galtons favourite hack in Damaraland, 1237 Plate LIX Skewness, in the frequency distributions of sociological phenomena, 11 228 ...

Initially, all nodes are in Q with infinite travel time. † Note that the path itself is fully prescribed by assigning to each node the preceding node along its shortest path to the source. g. Johnsonbaugh [150]. The algorithm can be speeded up considerably by sorting the nodes in Q into a heap, which is defined as a set of N travel times Tj such that: Tj ≥ Tj/2 for 1 ≤ j/2 < j ≤ N . A heap is a comparatively fast way to find the fastest path among a set of paths without having to sort the whole set. 9 travelling from A to B, and secondary source at C on the wavefront, at a distance h from the direct path AB. Energy from C will arrive at B with a delay. If AB has length L, and C, when projected on AB is at a distance s from A, then the difference in length is: ACB − AB = s 2 + h2 + (L − s)2 + h2 − L ≈ h2 2 1 1 + s L−s , 32 Ray theory for seismic waves where we use a first-order Taylor expansion for small h/s and h/(L − s). The secondary wave will still interfere ...

Early this year, yet another friend of mine up and died. There was of course a mess of things that had to be figured out. It wasnt just the traditional things of cleaning out her house (I wasnt around for that part) or figuring out the funeral (Viking in variety). It was new and interesting technical and moral turmoil of getting into her hard drive, questions of should we even?- her prolific music and authoring contributions rivaled by her extreme privacy. It was seeking the edges of her far-flung pockets of internet community to notify them personally, racing the deluge of social media notifications, not wanting them to find out about her the same way I found out about my grandmother - before the familial phone tree had reached me, a peripheral friend calling me based on a facebook post from my sister. A morbid seismic wave.. While I dont have any control over how others plan for (or dont) their demise, I have a say over my own. I can show my care for people dear to me my own compulsive, ...

Recently, to perform seismological prospecting using electronic computers, the authors began to calculate the shape and spectral composition of reflected waves formed in an assigned stratified medium - a model of an actual cross-section. Therefore, it was necessary to know the shape of the incident wave, i.e., the shape of the elastic impulse emitted by the blast. To accomplish this works were set up to study direct waves near the earths surface using a vibration excitation procedure common for seismological prospecting, i.e., using bore-hole explosions at a depth to several tens of meters.*Seismic waves

Because the earths mantle becomes more rigid and compressible as the depth below the asthenosphere increases, P-waves travel faster as they go deeper in the mantle. The density of the mantle also increases with depth below the asthenosphere. The higher density reduces the speed of seismic waves.. ...

Seismic inverse Q filtering is a data processing technology for enhancing the resolution of reflection seismology images. Q is the anelastic attenuation factor or the seismic quality factor, a measure of the energy loss as the seismic wave moves. Seismic inverse Q-filtering employs a wave propagation reversal procedure that compensates for energy absorption and corrects wavelet distortion due to velocity dispersion. By compensating for amplitude attenuation with a model of the visco-elastic attenuation model type, seismic data can provide true relative-amplitude information for amplitude inversion and subsequent reservoir characterization. By correcting the phase distortion due to velocity dispersion, seismic data with enhanced vertical resolution can yield correct timings for lithological identification. However, Wangs outline of the subject is excellent and to follow his path, inverse Q filtering can be introduced based on the 1-D one-way propagation wave equation. He introduce this ...

Deletion of Mir29 increased lifespan in males and decreased lifespan in females. In males mean lifespan was 14% higher and maximum lifespan was 7% higher compared to wild type mice. In females mean lifespan was 11% lower and maximum lifespan was 6% lower compared to wild type mice ...

Answers to your questions about Nicolas Ansells life, age, relationships, sexual orientation, drug usage, net worth and the latest gossip!

Scientists analyzing results of spinning protons striking different sized atomic nuclei at the Relativistic Heavy Ion Collider (RHIC) found an odd directional preference in the production of neutrons that switches sides as the size of the nuclei increases.

Messers Telford and Rawcliffe have just sold Halenook Thor, a Starline Decision son with strong female breeding females. He has a calving ease of +2.4 and