TY - JOUR. T1 - Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes. AU - Benitez-Aguirre, P.Z.. AU - Craig, M.E.. AU - Cusumano, J.. AU - Jenkins, A.J.. AU - Donaghue, K.C.. AU - Sasongko, M.B.. AU - Cheung, N.. AU - Wong, T.Y.. PY - 2012/3/1. Y1 - 2012/3/1. N2 - OBJECTIVE - To examine the relationship between retinal vascular geometry parameters and development of incident renal dysfunction in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER ,7.5 µg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline ...
In pre-clinical safety studies, drug-induced vascular injury (DIVI) is defined as an adverse response to a drug characterized by degenerative and hyperplastic changes of endothelial cells and vascular smooth muscle cells. Inflammation may also be seen, along with extravasation of red blood cells into the smooth muscle layer (i.e., hemorrhage). Drugs that cause DIVI are often discontinued from development after considerable cost has occurred. An in vitro vascular model has been developed using endothelial and smooth muscle cells in co-culture across a porous membrane mimicking the internal elastic lamina. Arterial flow rates of perfusion media within the endothelial chamber of the model induce physiologic endothelial cell alignment. Pilot testing with a drug known to cause DIVI induced extravasation of red blood cells into the smooth muscle layer in all devices with no extravasation seen in control devices. This engineered vascular model offers the potential to evaluate candidate drugs for DIVI early in
Benitez-Aguirre PZ, Wong TY, Craig ME, Davis EA, Cotterill A, Couper JJ, Cameron FJ, Mahmud FH, Jones TW, Hodgson LAB, Dalton RN, Dunger DB, Donaghue KC, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT). The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes. Diabetologia 61 (4) : 968 - 976(2018) PubMed (Grant IDs: 632521 ...
Although the quantitative analysis of electromechanical alternans is important, previous studies have focused on electrical alternans, and there is a lack quantitative analysis of mechanical alternans at the subcellular level according to various basic cycle lengths (BCLs). Therefore, we used the excitation-contraction (E-C) coupling model of human ventricular cells to quantitatively analyze the mechanical alternans of ventricular cells according to various BCLs. To implement E-C coupling, we used calcium transient data, which is the output data of electrical simulation using the electrophysiological model of human ventricular myocytes, as the input data of mechanical simulation using the contractile myofilament dynamics model. Moreover, we applied various loads on ventricular cells for implementation of isotonic and isometric contraction. As the BCL was reduced from 1000 to 200 ms at 30 ms increments, mechanical alternans, as well as electrical alternans, were observed. At this time, the myocardial
The image-based arterial geometries used in patient-specific arterial fluid-structure interaction (FSI) computations, such as aorta FSI computations, do not come from the zero-stress state (ZSS) of the artery. We propose a method for estimating the ZSS required in the computations. Our estimate is based on T-spline discretization of the arterial wall and is in the form of integration-point-based ZSS (IPBZSS). The method has two main components. (1) An iterative method, which starts with a calculated initial guess, is used for computing the IPBZSS such that when a given pressure load is applied, the image-based target shape is matched. (2) A method, which is based on the shell model of the artery, is used for calculating the initial guess. The T-spline discretization enables dealing with complex arterial geometries, such as an aorta model with branches, while retaining the desirable features of isogeometric discretization. With higher-order basis functions of the isogeometric discretization, we ...
2017 - English 1 Abstract: Time-dependent and three-dimensional flow of Newtonian fluid is studied in context of two biomechanical applications, flow in cerebral aneurysms and flow in stenotic valves. In the first part of the thesis, the computational meshes obtained from the medical imaging techniques are used for the computation of hemodynamic parameters associated with the rupture potency of the cerebral aneurysms. The main result is the computation within twenty geometries of aneurysms. It is shown that the aneurysm size has more important role in wall shear stress distribution than the fact whether the aneurysm is ruptured or unruptured. The second part of the thesis is addressed to the flow in stenotic valves. It is shown that the method cur- rently used in medical practice is based on assumptions which are too restrictive to be apply to blood flow in the real case. The full continuum mechanics model is presented with physiologically relevant boundary conditions and it is shown that ...
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Personalised cardiac models have attracted increasing interest from the clinical community over the past decade, however clinical validation is often restricted to few cases. This is due to the computational complexity of the models and of their personalisation, but also to the difficulty of acquiring the extensive datasets required for such personalised models. In this talk, I will present exemples of clinical applications where we leveraged on data science in order to increase the applicability and robustness of such personalised cardiac models. Machine learning methods have been developed in order to benefit from both the physiological constraints of the model and the efficiency of the learning.. ...
Since switching to BBB method last summer I am having a recurrent problem with algae just on the pool walls. It poofs up when brushed and is bright green. I will go through the shock process despite water being clear and cc 0 with no overnight fC loss. The chlorine did not go below 8-10 last 2 weeks (I have SWG by the way) and I kept it there and I still saw algae reappearing on walls. We brush once a week (I have a bad back). Filter pressure good at 10. From opening until a couple of weeks ago
Stocks are opening higher on Wall Street following three days of losses and the biggest one-day drop in the S&P 500 since February. Big Tech companies like Apple and Microsoft, which had posted some of the bigger losses this week, were rising in the early going Thursday. the S&P 500 added 0.8% in the first […]
Assumption #2 was tested by artificially slowing down search for a cohort of users. These users did not necessarily react positively to slower results. But their engagement level was not statistically significantly lessened.). The point of McKinleys talk was that instead of having the goal of test infinite scroll, Etsy realized it needed to test each assumption separately, and this going forward is their game plan (the success case McKinley gives is the revamp of Etsys search box).. As I said, a great talk worth checking out. However, McKinley didnt have an answer for this:. Even if user engagement isnt positively influenced by more results per page or by faster results, why does the combination of both have a decidedly negative impact?. The decision to try infinite scroll was partially influenced by Google apparent success with instant search results, according to McKinley. And its a feature that is prominent among popular Tumblr themes, Pinterest, and of course, at Facebook and ...
In a dark study sits the Scroll Table Lamp, softly glowing in the room. Create that feel in your space with the lamps scroll design and brown brush finish.
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Demoing how to use scroll snap points to make a many page gallery or scrolling site. Im using a polyfill here for full support, but if you want to se...
Nevro posted Q4 results that beat the consensus forecast on Wall Street as it issued 2021 guidance that was slightly below expectations.
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Printed from: http://www.jewishpress.com/news/breaking-news/ein-gedi-scroll-target-of-hi-tec-recovery-mission/2016/09/22/. Scan this QR code to visit this page online ...
The semileptonic decay B→π is studied starting from a simple quark model and taking into account the effect of the B* resonance. A novel, multiply subtracted, Omnès dispersion relation has been implemented to extend the predictions of the quark model to all physical q2 values. We find ,Vub, = 0.0034 ± 0.0003(exp.) ± 0.0007(theory), in good agreement with experiment.. Full text not available from this repository.. ...
If you dont have the time for it, I would be happy to take a look at that on an evening this week, should take me no more than 15 minutes so its no problem at all. I would be really thankful - I just dont want to scroll a page for 15 minutes just because some people think the best way of doing l ...
Create a score with enough staves that you can scroll the top staff off the top of the screen in page view. Copy notes from somewhere, possibly another score…
RESEARCH DESIGN AND METHODS A prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER ,7.5 μg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline retinal photographs. Generalized estimating equations were used to examine the relationship between incident renal dysfunction and baseline venular LDR and ST, adjusting for age, diabetes duration, glycated hemoglobin (A1C), blood pressure (BP), BMI, and cholesterol. ...
The calculation of temperature change in the products solid geometry is an option selection. Conjugate heat transfer through convection, conduction, and radiation can be created. Calculations can include thermal contact resistance.. SOLIDWORKS Flow Simulation: Calculate pure heat conduction in solids to identify problems where no fluid exists for fast solutions.. SOLIDWORKS Flow Simulation and HVAC Module: Include materials that are semitransparent to radiation, for accurate solutions where the products thermal load is influenced by transparent materials.. SOLIDWORKS Flow Simulation and Electrical Cooling Module: Simulate specific electronics device effects. ...
We analyze the performances of two types of Luenberger observers -- namely, the so-called Direct Velocity Feedback and Schur Displacement Feedback procedures, originally devised for elasto-dynamics -- to estimate the state of a fluid-structure interaction model for hemodynamics, when the measurements are assumed to be restricted to displacements or velocities in the solid. We first assess the observers using hemodynamics-inspired test problems with the complete model, including the Navier-Stokes equations in Arbitrary Lagrangian-Eulerian formulation, in particular. Then, in order to obtain more detailed insight we consider several well-chosen simplified models, each of which allowing a thorough analysis -- emphasizing spectral considerations -- while illustrating a major phenomenon of interest for the observer performance, namely, the added mass effect for the structure, the coupling with a lumped-parameter boundary condition model for the fluid flow, and the fluid dynamics effect per se. Whereas
The success of stent implantation in the restoration of blood flow through areas of vascular narrowing is limited by restenosis. Several recent studies have suggested that the local geometric environment created by a deployed stent may influence regional blood flow characteristics and alter distributions of wall shear stress (WSS) after implantation, thereby rendering specific areas of the vessel wall more susceptible to neointimal hyperplasia and restenosis. Stents are most frequently implanted in curved vessels such as the coronary arteries, but most computational studies examining blood flow patterns through stented vessels conducted to date use linear, cylindrical geometric models. It appears highly probable that restenosis occurring after stent implantation in curved arteries also occurs as a consequence of changes in fluid dynamics that are established immediately after stent implantation. In the current investigation, we tested the hypothesis that acute changes in stent-induced regional geometry
Although spiral waves are ubiquitous features of nature and have been observed in many biological systems, their existence and potential function in mammalian cerebral cortex remain uncertain. Using voltage-sensitive dye imaging, we found that spiral waves occur frequently in the neocortex in vivo, both during pharmacologically induced oscillations and during sleep-like states. While their life span is limited, spiral waves can modify ongoing cortical activity by influencing oscillation frequencies and spatial coherence and by reducing amplitude in the area surrounding the spiral phase singularity. During sleep-like states, the rate of occurrence of spiral waves varies greatly depending on brain states. These results support the hypothesis that spiral waves, as an emergent activity pattern, can organize and modulate cortical population activity on the mesoscopic scale and may contribute to both normal cortical processing and to pathological patterns of activity such as those found in epilepsy.
Fluid-Structure Interactions in Low-Reynolds-Number Flows (RSC Soft Matter Series, Book 4) by Camille Duprat and Howard A Stone English | 2015 | ISBN: 1849738130 | 483 pages | PDF | 160 MB
The major challenge for applying cardiovascular models in personalized medicine is as follows: How certain are the predictions of a cardiovascular model, taking the natural variations and measurement uncertainty of model inputs into account?. To address this challenge, we combined methodologies for uncertainty quantification (UQ) and sensitivity analysis (SA) with cardiovascular models. In a comprehensive guide to UQ and SA, we showed how to quantify the uncertainties of model predictions and the sensitivity of model predictions with respect to model inputs. The approach is exemplified for two clinically relevant models, predicting the following: i.) the severity of coronary artery stenosis, which is a predisposition to stroke and transient ischaemic attack, and ii.) the total arterial compliance, which is considered to be a cardiovascular risk factor, indicating the development of hypertension and atherosclerosis. Furthermore, we developed a framework for UQ and SA in a one-dimensional blood ...
TY - JOUR. T1 - Remodeling of blood vessels. T2 - Responses of diameter and wall thickness to hemodynamic and metabolic stimuli. AU - Pries, Axel R.. AU - Reglin, Bettina. AU - Secomb, Timothy W.. PY - 2005/10. Y1 - 2005/10. N2 - Vascular functions, including tissue perfusion and peripheral resistance, reflect continuous structural adaptation (remodeling) of blood vessels in response to several stimuli. Here, a theoretical model is presented that relates the structural and functional properties of microvascular networks to the adaptive responses of individual segments to hemodynamic and metabolic stimuli. All vessels are assumed to respond, according to a common set of adaptation rules, to changes in wall shear stress, circumferential wall stress, and tissue metabolic status (indicated by partial pressure of oxygen). An increase in vessel diameter with increasing wall shear stress and an increase in wall mass with increased circumferential stress are needed to ensure stable vascular adaptation. ...
Simulation of blood flow and vessel deformation in three-dimensional, patient-specific models of the cardiovascular system using a novel method for fluid-solid interactions Conference Proceeding ...
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Atherosclerotic plaques are distributed differently in the aortic arches of C57BL/6 (B6) and 129/SvEv (129) apolipoprotein E (apoE)-deficient mice. It is now recognized that hemodynamic wall shear stress (WSS) plays an important role in the localization of atherosclerotic development. Since the blood flow field in the vessel is modulated by the vascular geometry, we quantitatively examined the difference in the aortic arch geometry and hemodynamic WSS between the two corresponding wild-type mouse strains. The three-dimensional (3D) geometry of 14 murine aortic arches, seven from each strain, was characterized using casts and stereo microscopic imaging. Based on the geometry of each cast, an average 3D geometry of the aortic arch for each mouse strain was obtained, and computational fluid dynamic calculations were performed in the two average aortic arches. Many geometric features, including aortic arch shape, vessel diameter, and branch locations, were significantly different at ...
FIG. 1 is a front perspective view of physiological pressure monitoring instrument embodying our design;. FIG. 2 is a front elevational view thereof;. FIG. 3 is a left side elevational view thereof;. FIG. 4 is a right side elevational view thereof;. FIG. 5 is a back elevational view of the instrument case, showing the side opposite that shown in FIG. 1;. FIG. 6 is a top plan view thereof.. FIG. 7 is a bottom plan view thereof.. ...
The results in this study indicate significant relationships between dynamic geometry and vessel wall thickness. The R2 values of the univariate regressions indicate that no single geometric factor has a dominant role in determining vessel wall thickness. On the other hand, the probability values of the multivariate regressions are all highly significant, and the correlation coefficients are substantially higher as well. Thus, thickening seems to be influenced by multiple aspects of the dynamic vascular geometry. This is to be expected; the geometric factors are postulated to act through their influence on the fluid dynamic and mechanical stresses experienced by the wall, and it is reasonable that each of these stresses would be influenced by multiple dynamic and geometric parameters. It is noteworthy in this respect that the signs of the regression coefficients in the univariate and multivariate regressions in Tables 2 and 3⇑ are consistent.. According to the signs of the regression ...
We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms-namely, the effects of an increased extracellular potassium concentration diffusing in space-that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures-and connecting these dynamics to specific biological mechanisms-promises new insights to treat this devastating disease ...
A tribute to the life and work of Tayfun E. Tezduyar on the occasion of his 60th Birthday Chapters discuss recent trends and new directions in
Rotating Regions can be used in analysis of fluid flow where components are rotating over different axes and/or at different speeds or if the computational domain is non-axisymmetric with respect to rotating component. Each rotating region is surronded by axisymmetric rotating region which has its own coordinate system rotating together with the component. Influence of rotation is taken into account in each of the rotating coordinate systems. To connect solutions within rotating regions and in the non-rotating part of computational domain, special internal boundary conditions are set automatically at fluid boundaries of the rotating regions. The values of flow parameters transferred as boundary conditions from adjacent fluid regions are averaged circumferentially over each rotating region. Image below shows how the averaging across the boundary affects the solution. ...
Thermal tracking on walls appears as dark soot stains. The air in the house must be full of moisture and warmer than the wall to produce the stains. Once the warm, damp air touches a cooler spot on the wall, some of the airs moisture coats the walls surface with condensation.
Deciphering a scroll isnt figuring out what it is. Its figuring our what all the damn squiggles are. As a real-world example, consider the simple ampersand (&). Do you have any idea how many different ways scribes have drawn a symbol that means and? Theres a surprising amount of variation, and if youre not prepared for it, this can make it hard to read. Medieval scribes were often called upon to make long documents, and the list of random squiggles they used to simplify their job was immense. Even names got abbreviated, and you were just supposed to know that Dy meant Dorothy, not Dylan or Dyvas. Good Lord, we do that today in text messaging and text channels.. As per rules, if the person who wrote the scroll is there, you can ask him What the hell does qq. mean? Just knowing that this is a scroll of fireball doesnt tell you how to activate the scroll. To actually activate it, you need to pronounce qq. correctly.. ...
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The anisotropic electrical conduction within myocardial tissue due to preferential cardiac myocyte orientation (fibre orientation) is known to impact strongly in electrical wavefront dynamics, particularly during arrhythmogenesis. Faithful representation of cardiac fibre architecture within computational cardiac models which seek to investigate such phenomena is thus imperative. Drawbacks in derivation of fibre structure from imaging modalities often render rule-based representations based on a priori knowledge pr
Hopp til første side Spline Representation n Spline representation of the first and last volume n Interpolation in time between these volumes n Animation of the mesh
Learn how SOLIDWORKS Flow Simulation enables you to quickly and easily simulate liquid and gas flows through and around your designs to calculate product performance and capabilities.. Go Further: Explore the Benefits of SOLIDWORKS Flow Simulation and Concurrent Engineering. Learn more about SOLIDWORKS Plastics by visiting solidworks.com/flow. ...
Dear all, My webpage is divided into - #header - #nav (which is a toolbar on the left) - #content - #footer How can I add a scroll bar to my #content (so that only my content scrolls up and down, with my navigation, header and footer all remaining not moving). This is an example (although I prefer to have a different scroll bar): http://www.zhangxiaogang.org/Enworks.aspx?type=year
Rotors or vortex action potentials with a diameter of about 1 centimeter and a rotation period of about 0.1 second occur in normal myocardium just before transition to fibrillation, a disorderly pattern of action potential propagation. Numerical models and corresponding mathematical analysis have recently suggested candidate mechanisms, all two-dimensional, for this transition from periodic electrical activity to something resembling turbulence. However, comparably recent experiments unanimously show that rotors, and the spiral waves they radiate, remain stably periodic in two-dimensional myocardium. This seeming paradox suggests a transition mediated through disorderly dynamics of the electrical vortex in three dimensions, as a vortex filament. ...
DERs Restoration Potential Model (RPM) Tool displays information that can be used to evaluate the relative ecological benefit of removing any known dam in the Commonwealth.
Fluid-structure interactions (FSI), i.e., the interplay of some moveable or deformable structure with an internal or surrounding fluid, are among the most widespread and most challenging coupled or mu
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Download Scroll Text shareware, freeware, demo, software, files... This applet displays a blinds effect between any images. This applet displays a cool blobs effect
Myocardial fiber orientation is a topic that has recently received much attention in connection with cardiac pumping function. The twisting motion of the cardiac base to apex can be a direct result of
this is the best way to learn back flips well its one way of learning them. have a nice soft mat and a wall and just keep running.
Global stocks rallied in the European and US session on Monday and experienced their best days in weeks. The markets also took note of the Feds comments that the US economy is expected to recover steadily towards the second half of the year but the recovery could drag through 2021.
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Here is some backgroud -- skip to the next paragraph for the meat of the problem. I have been fighting an issue with the mouse scroll wheel in (KDE based) Linux guests for quite some time now. It seemed to surface for me with the Fedora 22 release (possibly due to the KDE version included there). This issue does not occur in prior versions of the OS (such as Fedora 21), but does occur consistently in every version since (up through the current, Fedora 24). I had written this off to be solely an OS or desktop (KDE) issue, which is why I had not brought it here for help yet. However, I did some additional testing recently which has convinced me that this at least partially lies on the VirtualBox side. I took some time recently to to install a VirtualBox guest OpenSUSE KDE system and it encountered the exact same symptoms as the Fedora system. Then I took the (extensive) time to setup and configure an ArchLinux KDE system, and it too experienced the same symptoms. The final test that led me to post ...
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The GUYTON model is still the most comprehensive cardiovascular model with a solid physiological background. However, it does not account for short...
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Stock buybacks are generally considered a bullish signal on Wall Street. They return capital to shareholders, while declaring managements belief that...
Richard Fuld is having a hard time putting the past behind him. As former Lehman employees have moved on, their former boss meets a rare degree of skepticism as he seeks to rebuild his presence on Wall Street.
This demo site is only for demonstration purposes. All images are copyrighted to their respective owners. All content cited is derived from their respective sources.. ...
Oh neat, hadnt heard of that. And dam 8GB?? I barely scratch 2GB. I jut cant find other textures mods worth adding myself. I thought Skyrim 2K HD would...
You can see how to activated downloaded Windows 7 themes in recent MakeUseOf article, Top 5 Windows 7 Themes You Might Want To Try. Scroll towards the end of the article.. ...
The GtkViewport widget acts as an adaptor class, implementing scrollability for child widgets that lack their own scrolling capabilities. Use GtkViewport to scroll child widgets such as GtkTable, GtkBox, and so on.. If a widget has native scrolling abilities, such as GtkTextView, GtkTreeView or GtkIconview, it can be added to a GtkScrolledWindow with ...
Scroll: Jean-Claude Claeys, Christine Clavel, Ladronn, Nathalie Lial, Stephan Martiniere, Jean-Pierre Normand. Anne-Claire Payet, Jean-Michel Ponzio, Adam Tredowski, Yoz ...