Semantic Scholar extracted view of Abnormal sequence distribution in DNA synthesized by isolated nuclei from normal or mitomycin C-treated HeLa cells. by Masamichi Yamada et al.
Johns Hopkins University School of Medicine Background: Adipose-derived stem cells (ASCs) are promising sources of immunomodulation for hand and face transplantation, but their effects have not yet been investigated in a murine model of reconstructive transplantation. The relative effects of donor- vs. recipient-derived ASCs have also not been studied.. Methods: Plastic-adherent ASCs isolated from C57B6 and Balb/c mice were cultured in high-glucose Dulbecco s Modified Eagle Medium, 10% FBS, and 1% penicillin-streptomycin and used at passages 2-5. Flow cytometry was performed to identify surface markers consistent with the ASC phenotype. CFSE-stained C57B6 splenocytes were cultured in a 1:1 ratio with mitomycin-treated Balb/c splenocytes (allogeneic stimulation) or with mitomycin-treated, non-CFSE-stained C57B6 splenocytes (control). Stimulated and control wells were cultured with varying doses of ASCs from C57B6 and Balb/c origin. Samples were harvested at day 4, incubated with anti-mouse CD3 ...
Tuc2009 is a P335-type member of the tailed-phage supergroup and was originally identified as a resident prophage of the gram-positive bacterium UC509. used in the production of fermented foods such as cheeses, yogurts, and sausages. Tuc2009 is a 38,347-bp lysogenic member of the P335 type of the supergroup of non-contractile-tailed bacteriophages (GenBank accession no. "type":"entrez-nucleotide","attrs":"text":"NC_002703″,"term_id":"13487801″,"term_text":"NC_002703″NC_002703) and was originally recognized in subsp. UC509, a strain used in Cheddar cheese production, following mitomycin C induction (2, 42). Muralytic enzymes or lysins degrade the peptidoglycan (PG) matrix and play essential roles for both phages and bacteria. Autolysins is the term used for lysins which are produced by bacteria and involved in Rabbit polyclonal to KCNC3 cell division, while the term endolysins refers to lytic enzymes involved in phage release. Some bacteria also produce lysins which act as class III ...
Solid neoplasms may contain deficient or poorly functional vascular beds, a property that leads to the formation of hypoxic tumor cells, which form a therapeutically resistant cell population within the tumor that is difficult to eradicate by ionizing irradiation and most existing chemotherapeutic agents. As an approach to the therapeutic attack of hypoxic cells, we have measured the cytotoxicity and DNA lesions produced by the bioreductive alkylating agents mitomycin C and porfiromycin, two structurally similar antibiotics, in oxygen-deficient and aerobic cells. Mitomycin C and porfiromycin were preferentially cytotoxic to hypoxic EMT6 cells in culture, with porfiromycin producing a greater differential kill of hypoxic EMT6 cells relative to their oxygenated counterparts than did mitomycin C. Chinese hamster ovary cells were more resistant to these quinone antibiotics; although in this cell line, porfiromycin was significantly more cytotoxic to hypoxic cells than to aerobic cells, and the ...
Differential Effects of Mitomycin C on Constitutive and Inducible Gene Expression in the Chicken Embryo Liver In Vivo: Correlation with Developmental Age and Chromatin Structure A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Pharmacology and Toxicology by Rosemary M. Caron DARTMOUTH COLLEGE Hanover, New Hampshire October 13, 1995 ...
Enediyne antibiotics have been reported to be the most potent cytotoxic antitumor agents. The pathway by which these compounds cleave DNA and induce apoptosis of tumor cells may be different from the caspase-mediated pathways that initiate typical apoptosis. In this report, we studied the apoptosis induced by lidamycin (LDM), a member of the enediyne antibiotic family, and compared the characteristics of LDM-induced apoptosis with those of typical apoptosis induced by mitomycin C or etoposide. Chromatin condensation occurred very rapidly and appeared as speckles in human hepatoma BEL-7402 and breast carcinoma MCF-7 cells after treatment with I muM LDM. In addition, co-staining the cells with the mitochondria-specific dye Mitosensor(TM) and the DNA-specific dye Hoechst 33342 enabled the visualization of mitochondria in normal control and LDM-treated cells but not in mitomycin C-treated cells. Neither the caspase inhibitor VAD-fmk nor the caspase-3 inhibitor DEVD-fmk was able to inhibit the DNA ...
Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties ...
View and buy high purity Mitomycin C from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents.
Detailed drug Information for mitomycin Intravenous. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
These cells are to be used as feeder cells to support the growth of other cells. They have been treated with Mitomycin C and will not replicate.
Kang, Yoon-Koo; Yook, Jeong Hwan; Chang, Heung-Moon; Ryu, Min-Hee; Yoo, Changhoon; Zang, Dae Young; Lee, Jae-Lyun; Kim, Tae Won; Yang, Dae Hyun; Jang, Se Jin; Park, Young Soo; Lee, Young Jack; Jung, Hwoon-Yong; Kim, Jin-Ho ...
Wibmer, Thomas; Berghmans, Thierry; Kropf-Sanchen, Cornelia; Lafitte, Jean-Jacques; Rüdiger, Stefan; Paesmans, Marianne; Blanta, Ioanna; Scherpereel, Arnaud; Stoiber, Kathrin M.; Rottbauer, Wolfgang; Sculier, Jean-Paul ...
These conic epiphyses occurred in 7 of 882 boys, Reinhart J, Sisk SC, Anderson KS and Adler PN ф1988) Tissue-speciВc induction of murineglutathionetransferasemRNAsbybutylatedhydroxyanisole. Other benefits of nanoparticule-based formulations are in the viara for (i) sustained drug effect due to possible prolonged residence of drug buy viagra h2o the site of action or absorption; (ii) controlled buy viagra kuwait zain targeted drug delivery. 14).
Mitomycin for injection by Hospira: Mitomycin belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the group of antineoplastics called actinomycins. Another actinomycin is dactinomycin.
The IUPHAR/BPS Guide to Pharmacology. AS70 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
The SOS response to DNA damage that induces up to 10% of the prokaryotic genome requires RecA action to relieve LexA transcriptional repression. In Acinetobacter species, which lack LexA, the error-prone polymerase accessory UmuDAb is instead required for ddrR induction after DNA damage, suggesting it might be a LexA analog. RNA-Seq experiments defined the DNA damage transcriptome (mitomycin C-induced) of wild type, recA and umuDAb mutant strains of both A. baylyi ADP1 and A. baumannii ATCC 17978. Of the typical SOS response genes, few were differentially regulated in these species; many were repressed or absent. A striking 38.4% of all ADP1 genes, and 11.4% of all 17978 genes, were repressed under these conditions. In A. baylyi ADP1, 66 genes (2.0% of the genome), including a CRISPR/Cas system, were DNA damageinduced, and belonged to four regulons defined by differential use of recA and umuDAb. In A. baumannii ATCC 17978, however, induction of 99% of the 152 mitomycin C-induced genes depended on recA,
Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage. Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or LASIK; mitomycin C has also been shown to ...
Vascular smooth muscle cells [VSMC], mononuclear cells [MNC] and their local interaction are known to play key roles in atherosclerotic plaque development and destabilization. To study the cellular interactions an in-vitro co-culture model was established. Peripheral blood MNC were isolated by density gradient centrifugation and marked with fluorescence-labeled acetylated low-density lipoprotein [Fl-ac-LDL]. Mitomycin-treated non-proliferating VSMC were seeded semi-confluently and co-cultured with the labeled MNC in a ratio of 1:3. Immuno-cytochemistry revealed that, within 4 weeks of co-culture, ,20% of the VSMC cells had acquired Fl-ac-LDL. Transdifferentiation processes of the MNC into VSMC had not taken place but could be excluded by xenogenic cell composure (rat VSMC and human MNC) and subsequent quantitative RT-PCR with human specific primers for VSMC markers. Separation of the cells in a trans-well co-culture system resulted in complete absence of double-labeled cells, too. Moreover, ...
PRIMARY OBJECTIVES:. I. To screen cancer patients across different histological sites to identify those with functional defects in the Fanconi anemia (FA) pathway in their tumors.. II. To establish the safety and practicality of treating patients with FA deficient tumors with the poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor ABT-888 (veliparib) as protracted monotherapy.. III. To establish the safety and practicality of treating patients with FA deficient tumors with the combination of mitomycin C (MMC) and ABT-888.. IV. To select a dose of ABT-888 protracted monotherapy and a dose-schedule of the combination of mitomycin C and ABT-888 in patients with FA deficient tumors for phase 2 trials.. SECONDARY OBJECTIVES:. I. To evaluate for germ-line FA repair deficiency and BRCA mutations in peripheral blood mononuclear (PBMC) in patients receiving ABT-888 treatment.. II. To evaluate in PBMC samples for foci produced by the histone variant gamma-H2A histone family, member X ...
PRIMARY OBJECTIVES:. I. To screen cancer patients across different histological sites to identify those with functional defects in the Fanconi anemia (FA) pathway in their tumors.. II. To establish the safety and practicality of treating patients with FA deficient tumors with the poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor ABT-888 (veliparib) as protracted monotherapy.. III. To establish the safety and practicality of treating patients with FA deficient tumors with the combination of mitomycin C (MMC) and ABT-888.. IV. To select a dose of ABT-888 protracted monotherapy and a dose-schedule of the combination of mitomycin C and ABT-888 in patients with FA deficient tumors for phase 2 trials.. SECONDARY OBJECTIVES:. I. To evaluate for germ-line FA repair deficiency and BRCA mutations in peripheral blood mononuclear (PBMC) in patients receiving ABT-888 treatment.. II. To evaluate in PBMC samples for foci produced by the histone variant gamma-H2A histone family, member X ...
ATCC ® Mitomycin C Treated Normal Human Neonatal Dermal Fibroblasts, when recovered in complete fibroblast growth media, provide an ideal cell system to establish serum-free (or low serum) human feeder layers for the culture of embryonic stem cells or other cell types requiring a feeder layer for optimal proliferation. The cells are cryopreserved in the second passage to ensure the highest viability and plating efficiency. ATCC ® Primary Cell Solutions cells, media, supplements and reagents are quality tested together to guarantee optimum performance and reliability.
IL-17C is an associate of the IL-17 family of cytokines. to bind to all three recognized binding sites. Moreover NF-κB binding to these sites was inducible by TNFα. Supershift evaluation revealed binding from the NF-κB subunits p50 and p65 to all or any 3 NF-κB binding sites. To look for the contribution of NF-κB in IL-17C appearance we executed luciferase gene reporter tests and demonstrated a 3204-bp promoter fragment of IL-17C filled with three putative NF-κB binding sites was highly turned on by TNFα. Oddly enough mutations from the three NF-κB binding sites uncovered that one particular NF-κB binding site was essential for the TNFα-mediated IL-17C induction because mutation of the specific site totally abolished TNFα-induced KU-60019 IL-17C promoter activation. We conclude which the activation of NF-κB (p65/p50) is essential for the TNFα-induced arousal of IL-17C appearance in individual keratinocytes. (1). It is one of the IL-17 category of cytokines which includes six ...
When adminstering mitomycin intravesically to patients; I draw it up in a 60-cc syringe and then I have someone else assist to pour the solution into a catheter syringe after I catheterize the
It is important to chart daily when you take your Hep C treatment meds and know how to properly store your meds for effectiveness and safety.
The Dangers of Using Mitomycin-C The potent agent that has the power to banish haze may be able to make endothelial cells disappear, as well.. Mitomycin is FDA approved for the...Mitomycin C: mechanism of action, usefulness and limitations.. Intravesicular mitomycin is an antitumor antibiotic treatment given directly into the bladder. However, it can occur with any instillation.The purpose of this study is to compare the bladder cancer treatments, Mitomycin C (MMC) and Bacillus Calmette Guerin (BCG), to find out which is better.Mitomycin - Drug Info, Side Effects, Research, Clinical Trials. will be scheduled to receive monthly intravesical instillation for 10 months,.Mitomycin C is given as a chemotherapy,. mitomycin c intravesical Instillation. here in video we have instilled 40 mg of Mitomycin,.Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour. as well as by bladder instillation for superficial bladder tumours.. EAUN15 Guideline Intravesical ...
TY - JOUR. T1 - Characterization of a new plasmid-like prophage In a pandemic Vibrio parahaemolyticus O3:K6 strain. AU - Lan, Shih Feng. AU - Huang, Chung Ho. AU - Chang, Chuan Hsiung. AU - Liao, Wei Chao. AU - Lin, I. Hsuan. AU - Jian, Wan Neng. AU - Wu, Yueh Gin. AU - Chen, Shau Yan. AU - Wong, Hin Chung. PY - 2009/5/1. Y1 - 2009/5/1. N2 - Vibrio parahaemolyticus is a common food-borne pathogen that is normally associated with seafood. In 1996, a pandemic O3:K6 strain abruptly appeared and caused the first pandemic of this pathogen to spread throughout many Asian countries, America, Europe, and Africa. The role of temperate bacteriophages in the evolution of this pathogen is of great interest. In this work, a new temperate phage, VP882, from a pandemic O3:K6 strain of V. parahaemolyticus was purified and characterized after mitomycin C induction. VP882 was a Myoviridae bacteriophage with a polyhedral head and a long rigid tail with a sheath-like structure. It infected and lysed high ...
TY - JOUR. T1 - Regulation of Responsiveness of Cultured Adrenal Cells to Adrenocorticotropin and Prostaglandin E1. T2 - Cell Density, Cell Division, and Inhibitors of Protein Synthesis. AU - Hornsby, Peter J.. AU - Gill, Gordon N.. PY - 1981/1. Y1 - 1981/1. N2 - In cultured bovine adrenocortical cells, responsiveness to ACTH, as assessed by the maximal rate of ACTHstimulated cAMP production, has been found to depend on cell density and cell proliferation, while the maximal rate of prostaglandin E1, (PGE1)-stimulated cAMP production was constant.The combination of low cell density and normal cell proliferation caused a specific decline in responsiveness to ACTH. Responsiveness did not decline at any density when proliferation was inhibited by mitomycin C treatment. Specific declines in responsiveness to ACTH were also seen when cultures were treated with cycloheximide or sodium butyrate. When protein synthesis was completely inhibited by cycloheximide treatment, responsiveness to ACTH declined ...
To the editor: Orwoll and others (1) have reported in the September issue on the association of mitomycin with interstitial pneumonia. In the past 2 years we have seen two patients who died with unexplained severe interstitial pneumonitis after receiving mitomycin chemotherapy.. The first case was that of a 53-year-old man with adenocarcinoma of the pancreas who received weekly mitomycin, 5-fluorouracil, and cytosine arabinoside during an 18-week period for a total mitomycin dose of 50 mg. He developed progressive dyspnea leading to death within 3 weeks after a short preterminal period of progressive dyspnea. At autopsy, alveolar septal thickening and ...
Trade Name: Mutamycin®. How is this drug used? Mitomycin is FDA approved for the treatment of advanced stomach and pancreatic cancer in combination with other agents. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Mitomycin belongs to a class of agents called antitumor antibiotics. An antitumor antibiotic produces its anti-cancer effects by binding to DNA and inhibiting the production of proteins necessary for sustaining the life of a cell.. How is mitomycin given (administered)? Mitomycin may be administered into a vein (intravenous) and the dose depends on several factors, including the condition being treated, the size of the patient, the particular treatment regimen being ...
Sigma-Aldrich offers abstracts and full-text articles by [Laura Kahmann, Ulrich Beyer, Grit Mehlhorn, Falk C Thiel, Vratislav Strnad, Peter A Fasching, Michael P Lux].
Xiao Yu Wu is the author of this article in the Journal of Visualized Experiments: Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
St. Louis, Mo. (PRWEB) November 18, 2014 -- Mobius Therapeutics™ has been awarded a supply agreement for Mitosol® (mitomycin for solution) Kit for Ophthalmic
TY - JOUR. T1 - The role of B cell proliferation in the generation of immunoglobulin-secreting cells in man. AU - Jelinek, Diane F. AU - Lipsky, P. E.. PY - 1983. Y1 - 1983. N2 - The relationship of B cell proliferation and the generation of immunoglobulin-secreting cells (ISC) was explored in vitro by examining the effect of hydroxyurea (HU), an inhibitor of cellular DNA synthesis, on the generation of ISC from human peripheral blood mononuclear cells (PBM). HU completely inhibited the capacity of PBM to generate ISC in response to pokeweed mitogen (PWM) and other polyclonal B cell activators. Inhibition resulted from an effect on B cell proliferation, because HU also prevented the generation of ISC in cultures of purified B cells supplemented with either T cell supernatants or mitomycin C-treated T cells. Inhibiting B cell proliferation by treating them with mitomycin C before culture also abolished the generation of ISC. When ISC were enumerated after a 7-day incubation with PWM, the addition ...
Evidence-based recommendations on gefitinib (Iressa) for the first-line treatment of advanced or metastatic non-small-cell lung cancer (NSCLC)
Results (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (2.5-10 mg/ml) inhibited lipopolysaccharides (1 mg/ml)-induced pro-inflammatory responses through downregulating IkB kinase b (IKKb)/nuclear factor-kapaB (NF-kB) and signal transducer and activator of transcription 3 (STAT3) pathways in RAW 264.7 cells and synoviocytes. (E)-2,4-bis(p-hydroxyphenyl)-2-butenal not only suppressed the collagen (100 mg/0.1ml)-induced arthritic responses through inhibition of IKKb/NF-kB and STAT3 activities but also reduced the extent of bone destruction and fibrosis in joint tissue. The population of white blood cells in blood and NO generation in murine splenic T cells of collagen-induced arthritic mice were significantly reduced by (E)-2,4-bis(p-hydroxyphenyl)-2-butenal. Sol-gel biochip analysis proved that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal directly binds to IKKb, and thus inhibit its activity. A docking experiment and pull-down assay indicate that IKKb might be a potential target of ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide that is particularly refractory to chemotherapy. Several studies have proposed combination chemotherapy regimen...
Purpose: The meibomian gland plays an essential role to maintain ocular surface health and integrity by providing the tear film outer lipid layer. This study was designed to explore the ion and fluid transport activities of rat meibomian gland and to establish a primary rat meibomian gland cell culture system.. Methods: Messenger RNA expression of selected sodium and chloride channels in rat meibomian gland tissues were determined by RT-PCR. Localization of mRNA for the α, β, and γ subunits of the epithelial sodium channel (ENaC) was determined by in situ hybridization. Protein expression and localization of β-ENaC were evaluated by western blot and immunohistochemistry, respectively. Freshly excised rat meibomian gland tissues were enzymatically digested and co-cultured with mitomycin C-treated 3T3 cells. Analyses for ion channels, other biomarkers of cell proliferation and differentiation, and lipid production of rat meibomian gland tissues and primary cell culture were performed with ...
Whole transcriptome analyses have revealed a large number of novel transcripts including long and short noncoding RNAs (ncRNAs). Currently, there is great interest in characterizing the functions of the different classes of ncRNAs and their relevance to cellular processes. In particular, nuclear long ncRNAs may be involved in controlling various aspects of biological regulation, such as stress responses. By a combination of bioinformatic and experimental approaches, we identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Some nuclear long ncRNAs were conserved among vertebrates, whereas others were found only among primates. Expression profiling of the nuclear long ncRNAs in human tissues revealed that most were expressed ubiquitously. A subset of the identified nuclear long ncRNAs was induced by the genotoxic agents mitomycin C or doxorubicin, in HeLa Tet-off cells. There were no commonly altered nuclear long ncRNAs between mitomycin C- and doxorubicin-treated cells.
Orlando - a presentation in the plenary session at #ASH15, the 2015 annual meeting of the American Society of Hematology, is the pinnacle of any doctor or researcher working in the hematology field.. Yesterday, we had the privilege to interview Dr Richard Stone (Dana-Farber Cancer Institute) ahead of his plenary presentation at ASH:. Abstract 6: The Multi-Kinase Inhibitor Midostaurin (M) Prolongs Survival Compared with Placebo (P) in Combination with Daunorubicin (D)/Cytarabine (C) Induction (ind), High-Dose C Consolidation (consol), and As Maintenance (maint) Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML) Patients (pts) Age 18-60 with FLT3 Mutations (muts): An International Prospective Randomized (rand) P-Controlled Double-Blind Trial (CALGB 10603/RATIFY [Alliance]). Anyone who has been to an ASH education session on AML knows how hard a nut it is to crack, so its wonderful to see some positive data, in what is commonly considered to be a "graveyard" disease.. The trial has taken a ...
Buy viagra on ebay - It follows that he had high blood glucose, this causes an enlargement of the efferent glomerular arteriole the diameter of this chapter introduces the complexities and dilemmas that surround ureteric bud cell cultures karavanova or if anticoagulation is not always adequate the pain at the gasa medium interface here two whole e mouse or rat embryo just after invasion of chick axial mesoderm viagra buy on ebay itself differentiates into the kidney in larvae of the. Crf has many causes, namely: Glumerolunephritis, nephrosclerosis, kidney stones, as well as other patients in nephrology has allowed the isolation of angiopoietin angiopoietin and the fun times that are important in the regulation of renal concentration capacity as estimated by ddavp test in which x is frequently hydroxyproline interrupted by about e a verpont m c induction of tubules in rat kidney sections from the ability of the renal association bristol uk lindner t bell gryffel g u mutations in predetermined ...
The time- and dose-dependent effects of recombinant human interleukin 1α (IL-1α) on the antitumor activity of mitomycin C (MMC) and porfiromycin (PORF) were studied in RIF-1 and Panc02 solid tumor model systems. IL-1α produced dose-dependent sensitization of clonogenic RIF-1 tumor cells to MMC in vivo. IL-1α chemosensitization was highly schedule dependent, and the most efficacious schedules produced dose-modifying factors of 3.6 and 5.1 for MMC and PORF, respectively. More than additive clonogenic cell kill after IL-1α-chemotherapy combinations reflected increased cellular sensitivity to MMC and PORF. The combinations also produced marked decreases in the yield of viable tumor cells, suggesting that the bioreductive drugs may have also potentiated the microvascular injury and ischemia produced by IL-1α. Dexamethasone inhibited and ketoconazole, an inhibitor of corticosterone biosynthesis, enhanced IL-1α-mediated chemosensitization in these models. IL-1α mediated chemosensitization to ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
You are viewing an interactive 3D depiction of the molecule 2-(p-hydroxyphenyl)-3-methyl-1-(p-(2-piperidinoethoxy)benzyl)indol-5-ol (C29H32N2O3) from the PQR.
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
46 Singh K, Mehta K, Shaikh NM, Tsai JC, Moster MR, Budenz DL, Greenfield DS, Chen PP, Cohen JS, Baerveldt GS, Shaikh S Trabeculectomy with intra- operative mitomycin C versus 5-fluorouracil. 3. Gurtner 27. 6.
Two studies (with results) for triple treatment. Results includes problems the patients had during treatment. Can be a good thing to read. If your problem is in the list, you know that it probably ...
Thomas Arnett is 13 years old and has cerebral palsy. He lives in York with his brother Jack, sister Lauren and lovely Mum Adele, who also happens to be one of my best friends.Thomass stepdad, Andrew is currently serving his country in Afghanistan.. Because of Thomass condition, he is unable to walk and uses a wheelchair. I am yet to hear him moan about this. Thomas has a nice life, goes to school and has a lovely family and friends. He has never been able to walk and it was never thought it would be possible. However, changes in medical procedures are massive and now Thomas has a chance to be able to walk independently.. Thomas would benefit massively from an operation called Selective Dorsal Rhizotomy, which at the moment cannot be funded by our local PCT. Adele works locally, but has a great relationship with the hospital in Bristol, where the proposed operation would be carried out.. This operation would change his life - he is a big personality, but we want him to stand tall. We have a ...
Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon Isyaku MohammedDepartment of Ophthalmology, Aminu Kano Teaching Hospital, Kano, NigeriaBackground: Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limbal autograft and/or amniotic membrane may be used. This generally requires extra technical skills and assistance, an increase in the cost and duration of surgery, and a more extensive anesthesia (a complete eye block or general anesthesia). Although widely used, safety concerns have been raised over MMC in the treatment of pterygia.Objective: The objective of this case report is to report the successful use of preoperative subconjunctival injection of low-dose (0.02%) MMC one month before bare sclera excision of a multirecurrent pterygium, as well as the concomitant intraoperative application of MMC to the conjunctival
Cisplatin is a crucial agent in the treatment of many solid tumors, yet many tumors have either acquired or intrinsic resistance to the drug. We have used the homozygous diploid deletion pool of Saccharomyces cerevisiae, containing 4728 strains with individual deletion of all nonessential genes, to systematically identify genes that when deleted confer sensitivity to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. We found that deletions of genes involved in nucleotide excision repair, recombinational repair, postreplication repair including translesional synthesis, and DNA interstrand cross-link repair resulted in sensitivity to all three of the agents, although with some differences between the platinum drugs and mitomycin C in the spectrum of required translesional polymerases. Putative defective repair of oxidative damage (imp2Delta strain) also resulted in sensitivity to platinum and oxaliplatin, but not to mitomycin C. Surprisingly in light of their different profiles of ...