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Sigma-Aldrich offers abstracts and full-text articles by [Evgeny S Egorov, Ekaterina M Merzlyak, Andrew A Shelenkov, Olga V Britanova, George V Sharonov, Dmitriy B Staroverov, Dmitriy A Bolotin, Alexey N Davydov, Ekaterina Barsova, Yuriy B Lebedev, Mikhail Shugay, Dmitriy M Chudakov].

T cells that recognize self antigen are clonally deleted in the thymus--a maturation process that occurs in the context of histocompatibility molecules and the T-cell receptor. The minor lymphocyte stimulation antigens (Mls) effect these deletions through interactions with the V beta portion of the T-cell receptor, thus mimicking bacterial superantigens. Intrigued by the fact that each known Mls gene maps to the same chromosomal region as an endogenous mouse mammary tumour virus (Mtv), we reevaluated the linkage relationships between the two gene families. Here we report perfect concordance in inbred and recombinant inbred mice between the presence of four Mtv proviruses with the expression of Mls gene products. These data suggest a general model in which mammary tumour virus gene products themselves are the ligands that shape a considerable portion of the immunological repertoire of common laboratory mice

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TY - JOUR. T1 - Effect of single intravenous administration of batroxobin on erythrocyte aggregability in patients with acute-stage cerebral infarction. AU - Tanahashi, N.. AU - Fukuuchi, Y.. AU - Tomita, M.. AU - Kobari, M.. AU - Takeda, H.. AU - Yokoyama, M.. AU - Itoh, D.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - We examined the effect of defibrinogenation with batroxobin on the erythrocyte aggregability (RBC-A) in 16 patients with cerebral infarction during the acute phase (less than 72 hours after onset). Eight patients received a single intravenous administration of 10 units of batroxobin (BU), while the other 8 patients received 5 BU. The RBC-A was examined using the whole-blood erythrocyte aggregometer developed by us (Am. J. Physiol. 251, H1205-H1210, 1986) with concomitant measurement of the hematocrit, albumin:globulin ratio and concentration of fibrinogen. The RBC-A values before, and at 1,2, and 7 days after 10 BU administration were 0.154±0.017/s, 0.117±0.029/s (76% of the value before ...