BACKGROUND AND PURPOSE: Endothelium-derived hyperpolarizing factor responses in the rat middle cerebral artery are blocked by inhibiting IKCa channels alone, contrasting with peripheral vessels where block of both IKCa and SKCa is required. As the contribution of IKCa and SKCa to endothelium-dependent hyperpolarization differs in peripheral arteries, depending on the level of arterial constriction, we investigated the possibility that SKCa might contribute to equivalent hyperpolarization in cerebral arteries under certain conditions. METHODS: Rat middle cerebral arteries (approximately 175 microm) were mounted in a wire myograph. The effect of KCa channel blockers on endothelium-dependent responses to the protease-activated receptor 2 agonist, SLIGRL (20 micromol/L), were then assessed as simultaneous changes in tension and membrane potential. These data were correlated with the distribution of arterial KCa channels revealed with immunohistochemistry. RESULTS: SLIGRL hyperpolarized and relaxed cerebral
This exhibit features two color coded illustrations of the brain, highlighting the territory of the middle cerebral artery. The first illustration consists of a lateral brain with the middle cerebral artery in situ. The area of blood supplied by the middle cerebral artery is delineated in yellow. The second image color codes the various areas of function within the middle cerebral artery territory of the brain.
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Our approach to look at cerebral autoregulation in migraineurs showed 2 striking results. First, the phase and gain behavior was completely different compared with the controls, and second, the spectral power magnitudes of BP and V were very much increased in the migraineurs.. One interpretation of the transfer function approach is to consider the cerebrovascular system as a high-pass filter, which delays low frequencies and lets pass through the higher beat-by-beat-depending frequencies.6,7 Phase and gain are 2 parameters to describe the filter. The findings in our controls can be interpreted in exactly that way. The V lead over BP in the controls means that slow BP changes are delayed before they enter the cerebrovascular bed. In migraineurs, the phase shift indicates that BP is always earlier in time than V, hence BP is driving V. If the filter indicates the presence or absence of cerebral autoregulation, it is evident that migraine patients lack autoregulation. An argument in favor of a real ...
We investigated the effect of acute hypoxia (AH) on dynamic cerebral autoregulation (CA) using two independent assessment techniques to clarify previous, conflicting reports. Twelve healthy volunteers (6 men, 6 women) performed six classic leg cuff tests, three breathing normoxic (Fi(O2) = 0.21) and three breathing hypoxic (Fi(O2) = 0.12) gas, using a single blinded, Latin squares design with 5-min washout between trials. Continuous measurements of middle cerebral artery blood flow velocity (CBFv; DWL MultiDop X2) and radial artery blood pressure (ABP; Colin 7000) were recorded in the supine position during a single experimental session. Autoregulation index (ARI) scores were calculated using the model of Tiecks et al. (Tiecks FP, Lam AM, Aaslid R, Newell DW. Stroke 26: 1014-1019, 1995) from ABP and CBFv changes following rapid cuff deflation (cuff ARI) and from ABP to CBFv transfer function, impulse, and step responses (TFA ARI) obtained during a 4-min period prior to cuff inflation. A new ...
Introduction Middle cerebral artery (MCA) and umbilical artery (UA) Doppler blood flow pulsatility indices (PIs) and MCA peak systolic velocity (PSV) are essential variables for clinically evaluating fetal well-being. Here we examined how a maternal meal influenced these Doppler blood flow velocity variables. Methods This prospective cohort study included 89 healthy Caucasian women with normal singleton pregnancies (median age, 32 years). Measurements were performed at gestational weeks 30 and 36, representing the start and near the end of the energy-depositing period. Measured variables included the MCA-PI, UA-PI, fetal heart rate (FHR) and MCA-PSV. The cerebroplacental ratio (CPR) was calculated as the ratio of MCA-PI to UA-PI. The first examination was performed in the fasting state at 08:30 a.m. Then participants ate a standard breakfast (approximate caloric intake, 400kcal), and the examination was repeated ~105 min after the meal. Results Without adjustment for FHR, fetal MCA-PI decreased ...
A resource for health professionals to improve prenatal ultrasound and accurate distinction between normal and abnormal anatomy. We believe this will save fetal lives and provide more reassurance to parents regarding their pregnancy
This page includes the following topics and synonyms: Middle Cerebral Artery CVA, Cerebrovascular Accident of Middle Cerebral Artery, MCA CVA.
Details of the image Haemorrhagic transformation of right middle cerebral artery ischaemic stroke Modality: CT (non-contrast)
A prospective cross-sectional study of fetal middle cerebral artery peak systolic velocity in a normal obstetric population attending an Indian Medical College ...
Differences between middle cerebral artery bifurcations with normal anatomy and those with aneurysms.: The objectives of this study were to elucidate the normal
Are the branches of the middle cerebral artery considered seperate and distinct vessels for the purposes of catheter placement and interventions (ie.
As I have described recently, I had surgery Dec. 19th for an M2, M3 right middle cerebral anuerysm clipped and have a question. Are/were any of you exhausted to...
TY - JOUR. T1 - Effects of heat stress on dynamic cerebral autoregulation during large fluctuations in arterial blood pressure. AU - Brothers, R. Matthew. AU - Zhang, Rong. AU - Wingo, Jonathan E.. AU - Hubing, Kimberly A.. AU - Crandall, Craig G.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Impaired cerebral autoregulation during marked reductions in arterial blood pressure may contribute to heat stress-induced orthostatic intolerance. This study tested the hypothesis that passive heat stress attenuates dynamic cerebral autoregulation during pronounced swings in arterial blood pressure. Mean arterial blood pressure (MAP) and middle cerebral artery blood velocity were continuously recorded for ∼6 min during normothermia and heat stress (core body temperature = 36.9 ± 0.1°C and 38.0 ± 0.1°C, respectively, P , 0.001) in nine healthy individuals. Swings in MAP were induced by 70-mmHg oscillatory lower body negative pressure (OLBNP) during normothermia and at a sufficient lower body negative pressure ...
Continuous positive airway pressure (C PA P) is a treatment modality for pulmonary oxygenation difficulties. C PA P impairs venous return to the heart and, in turn, affects cerebral blood flow (CBF) a
Complete ganglion blockade alters dynamic cerebral autoregulation, suggesting links between systemic autonomic traffic and regulation of cerebral blood flow velocity. We tested the hypothesis that acute head-down tilt, a physiological maneuver that decreases systemic sympathetic activity, would similarly disrupt normal dynamic cerebral autoregulation. We studied 10 healthy young subjects (5 men and 5 women; age 21 +/- 0.88 yr, height 169 +/- 3.1 cm, and weight 76 +/- 6.1 kg). ECG, beat-by-beat arterial pressure, respiratory rate, end-tidal CO2 concentration, and middle cerebral blood flow velocity were recorded continuously while subjects breathed to a metronome. We recorded data during 5-min periods and averaged responses from three Valsalva maneuvers with subjects in both the supine and -10 degrees head-down tilt positions (randomized). Controlled-breathing data were analyzed in the frequency domain with power spectral analysis. The magnitude of input-output relations were determined with cross
TY - JOUR. T1 - Different cerebral hemodynamic responses between sexes and various vessels in orthostatic stress tests. AU - Wang, Yuh Jen. AU - Chao, A. Ching. AU - Chung, Chih Ping. AU - Huang, Ying Ju. AU - Hu, Han Hwa. PY - 2010/9/1. Y1 - 2010/9/1. N2 - Objective: The argument about why the head-up tilt table test (HUT) does not include the posterior cerebral circulation, which is mainly responsible for syncope, as a monitor target has not been resolved. It is also unclear whether there is a sex difference in cerebral blood flow (CBF) changes. We hypothesized that orthostatic CBF changes more in the posterior circulation than in the anterior circulation and is different between sexes. Methods: Thirty healthy volunteers (13 female and 17 male) were recruited for the HUT. The blood pressure (BP), middle cerebral artery flow velocity (MCAFV), and posterior cerebral artery flow velocity (PCAFV) were monitored simultaneously. Static cerebral autoregulation (CA) was calculated. Results: The female ...
Authors: Kostoglou K, Debert CT, Poulin MJ, Mitsis GD.. We examined the time-varying characteristics of cerebral autoregulation and hemodynamics during a step hypercapnic stimulus by using recursively estimated multivariate (two-input) models which quantify the dynamic effects of mean arterial blood pressure (ABP) and end-tidal CO2 tension ( [Formula: see text] ) on middle cerebral artery blood flow velocity (CBFV). Beat-to-beat values of ABP and CBFV, as well as breath-to-breath values of [Formula: see text] during baseline and sustained euoxic hypercapnia were obtained in 8 female subjects. The multiple-input, single-output models used were based on the Laguerre expansion technique, and their parameters were updated using recursive least squares with multiple forgetting factors. The results reveal the presence of nonstationarities that confirm previously reported effects of hypercapnia on autoregulation, i.e. a decrease in the MABP phase lead, and suggest that the incorporation of [Formula: ...
Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility. 59 In an international, multi-centre study, we evaluated the influence of multiple analytical 60 methods on the reproducibility of DCA. Fourteen participating centers analyzed repeated 61 measurements from 75 healthy subjects, consisting of five minutes of spontaneous 62 fluctuations in blood pressure (BP) and cerebral blood flow velocity (CBFv) signals, based on 63 their usual methods of analysis. DCA- methods were grouped into three broad categories, 64 depending on output types: 1. Transfer function analysis (TFA); 2. Autoregulation index 65 (ARI); and 3. correlation coefficient. Only TFA gain in the low frequency (LF) band showed 66 good reproducibility in approximately half of the estimates of gain, defined as an intraclass 67 correlation coefficient (ICC) of , 0.6. None of the other DCA metrics had good 68 reproducibility. For TFA-like and ARI-like methods, ICCs were lower than values obtained 69 with ...
The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening low-frequency fluctuations in cerebral blood flow has not been clearly examined. In this study, we quantitatively assessed the contribution of arterial Windkessel (peripheral compliance and resistance) in the dynamic cerebral blood flow response to relatively large and acute changes in blood pressure. Middle cerebral artery flow velocity (MCA(V); transcranial Doppler) and arterial blood pressure were recorded from 14 healthy subjects. Low-pass-filtered pressure-flow responses (,0.15 Hz) during transient hypertension (intravenous phenylephrine) and hypotension (intravenous sodium nitroprusside) were fitted to a two-element Windkessel model. The Windkessel model was found to provide a superior goodness of fit to the MCA(V) responses during both hypertension and hypotension (R² = 0.89 ± 0.03 and 0.85 ± 0.05, respectively), with a ...
The Valsalva maneuver (VM) produces large and abrupt changes in mean arterial pressure (MAP) that challenge cerebral blood flow and oxygenation. We examined the effect of VM intensity on middle cerebral artery blood velocity (MCAv) and cortical oxygenation responses during (phase I, II, III) and following (phase IV) a VM. Healthy participants (n=20 mean ± SD: 27±7 y) completed 30 and 90% of their maximal VM mouth pressure for 10 s (order randomised) whilst standing. Beat-to-beat MCAv, cerebral oxygenation (NIRS) and MAP across the different phases of the VM are reported as the difference from standing baseline. There were significant interaction (phase * intensity) effects for MCAv, total oxygenation index (TOI) and MAP (all P
In the current evaluation of the dynamic relation between MBP oscillations and CBF fluctuations using transfer function analysis, coherence in the very-low- and low-frequency ranges was below 0.5 during administration of dexmedetomidine, with remarkable reduction in MBP variability. Because small coherence suggests any one of three possible mechanisms, i.e. , (1) a nonlinear relation between changes in pressure and velocity, (2) the presence of a low signal-to-noise ratio, or (3) a weak relation between the two signals, i.e. , effective autoregulation,10,11 the current study cannot reveal which process led to the small coherence. Many previous studies have estimated transfer function gain and phase as interpretable indices even if coherence was small.19,24,31-33 Moreover, changes in transfer function gain and phase are unlikely to be induced solely by alterations in arterial pressure variability.14,34 Therefore, increases in transfer function gain in the very-low-frequency range and phase ...
TY - JOUR. T1 - Herniation of an enlarged middle cerebral artery through a temporal bone defect in association with an arteriovenous malformation. AU - Raley, Darryl Alan. AU - Davidson, Andrew Stewart. AU - Morgan, Michael Kerin. PY - 2012/11. Y1 - 2012/11. N2 - We present a previously undescribed variant of the middle cerebral artery (MCA) protruding through a defect in the temporal bone, associated with a large arteriovenous malformation (AVM). The patient, a 59-year-old male, presented with a large right frontoparietal AVM with feeding aneurysms and a recent haemorrhage. Preoperative imaging demonstrated a tortuous right MCA feeder abutting the anterosuperior temporal bone in the region of the pterion. An associated temporal bone defect was visible. The patient underwent a pterional craniotomy for surgical clipping of aneurysms associated with the AVM. On reflection of the temporalis muscle, the MCA branch was transected as it coursed through a defect in the temporal bone. This patient ...
During the first hours after acute ischemic stroke, the CT usually shows no abnormalities.Therapeutic trials of ischemia in the middle cerebral artery (MCA) territory involves decision-making when the CT may not show obvious ischemic changes. We reviewed 100 consecutive patients, admitted within 14 hours after a first stroke. Selective criteria were clinical presentation with MCA ischemia and at least two CTs (1 initial and 1 control). All CTs were retrospectively analyzed by at least two physicians blinded to the patients status. On the first CT, early signs were hyperdense MCA sign (HMCAS), early parenchymatous signs (attenuation of the lentiform nucleus [ALN], loss of the insular ribbon [LIR], and hemispheric sulcus effacement [HSE]), midline shift, and early infarction. Subsequent infarct locations were classified according to total, partial superficial (superior or inferior), deep, or multiple MCA territories. Clinical features, etiology, and Rankin scale were collected. There were 52 ...
Advice on lifestyle changes (diet, red wine and physical activity) does not affect internal carotid and middle cerebral artery blood flow velocity in patients with carotid arteriosclerosis in a randomized controlled trial ...
Advice on lifestyle changes (diet, red wine and physical activity) does not affect internal carotid and middle cerebral artery blood flow velocity in patients with carotid arteriosclerosis in a randomized controlled trial ...
Advice on lifestyle changes (diet, red wine and physical activity) does not affect internal carotid and middle cerebral artery blood flow velocity in patients with carotid arteriosclerosis in a randomized controlled trial ...
The volume of cerebral tissue perturbed in experimental models of middle cerebral artery occlusion (MCAO) can be highly variable. Thus, the territories of reduced cerebral blood flow (CBF) or oxygen consumption (CMRO(2)) following MCAO might properly be defined using statistical parametric mapping within a population. In order to establish such a method, we mapped CBF and CMRO(2) in 18 pigs with acute MCAO. Parametric maps were flipped about the axis of symmetry, and CBF and CMRO(2) in the infarcted hemisphere were calculated as percentages of the magnitudes in mirror-image pixels. There were log-linear relationships between the volumes of affected tissue and the percentages of normal CFB or CMRO(2). This graphical analysis showed that the volume of the core deficit was smaller for CBF that for CMRO(2), but expanded more rapidly with decreasing CBF deficit than did the corresponding volumes of reduced CMRO(2). Thus, acute changes in CBF and CMRO(2) following MCAO in the pig can be defined as ...
This study proposes more objective methods for deciding the appropriate direction of the sylvian fissure dissection during surgical clipping in middle cerebral artery (MCA) bifurcation aneurysms. We reviewed data of 36 consecutive patients with
Dynamic cerebral autoregulation (dCA) is impaired following stroke. However, the relationship between dCA, brain atrophy, and functional outcomes following stroke remains unclear. In this study, we aimed to determine whether impairment of dCA is associated with atrophy in specific regions or globally, thereby affecting daily functions in stroke patients. We performed a retrospective analysis of 33 subjects with chronic infarctions in the middle cerebral artery territory, and 109 age-matched non-stroke subjects. dCA was assessed via the phase relationship between arterial blood pressure and cerebral blood flow velocity. Brain tissue volumes were quantified from MRI. Functional status was assessed by gait speed, instrumental activities of daily living (IADL), modified Rankin Scale, and NIH Stroke Score. Compared to the non-stroke group, stroke subjects showed degraded dCA bilaterally, and showed gray matter atrophy in the frontal, parietal and temporal lobes ipsilateral to infarct. In stroke subjects,
The purpose of this study was to characterize cerebrovascular responses to rowing exercise, investigating whether their diurnal variation might explain performance differences across a day. Twelve male rowers completed incremental rowing exercise and a 2000-m ergometer time trial at 07:00 h and 16:00 h, 1 week apart, while middle cerebral artery velocity (MCAv), cerebral (prefrontal), and muscular (vastus lateralis) tissue oxygenation and hemoglobin volume (via near-infrared spectroscopy), heart rate, and pressure of end-tidal CO2 (PET CO2) were recorded. MCAv was 20-25% above resting levels (68 ± 12 cm/s) during submaximal and maximal exercise intensities, despite PET CO2 being reduced during maximal efforts (down ∼ 0.5-0.8 kPa); thus revealing a different perfusion profile to the inverted-U observed in other exercise modes. The afternoon time trial was 3.4 s faster (95% confidence interval 0.9-5.8 s) and mean power output 3.2% higher (337 vs 347 W; P = 0.04), in conjunction with similar exercise
A 39-year-old 34-week-pregnant woman was referred to our hospital for preterm labor and fetal dysfunction. Fetal middle cerebral artery systolic maximum blood flow velocity was high, so fetal anemia was suspected. Blood type was O-type Rh (+) and fetal hemoglobin was 0.4%; tests for irregular antibody and human parvovirus B19 IgM were negative. A high brightness echoic mass was observed in fetal stomach bubble, and amniotic fluid appeared bright. Labor suppression was disabled, and emergency cesarean section was performed. Amniotic fluid turbidity was observed, and on suctioning the stomach content of the infant, turbid amniotic fluid containing blood was obtained. On placental pathological examination, the cause of bloody amniotic fluid was not identified. The infants hemoglobin level was low at 8.7 g/dL, so the infant received red cell concentrate, with improvement of general condition.
Synonyms for cerebral artery, posterior in Free Thesaurus. Antonyms for cerebral artery, posterior. 11 synonyms for artery: vein, blood vessel, route, way, course, round, road, passage, avenue, arteria, arterial blood vessel. What are synonyms for cerebral artery, posterior?
Diagnosis Code I60.12 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
Moris classification11,15 is helpful in predicting the likelihood of technical and clinical success. However, the technical success of stenting appears more closely related to the circumstances of access; the risk of complications as well as that of restenosis is related to the morphological features of the target lesion itself, while the occlusion risk of larger branches is related to the location of lesion. Based on this observation and concept, the authors put forward the LMA classification as described above, which served as a basis to work out the individual therapy planning.. Lateral projection of the cerebral arteries is used for evaluation of access. In this series, the only technical failure was caused by the inability of the stent to negotiate the extremely tortuous siphon of ICA (case 29, type III access). The successful rate of stenting of type III access (85.7%) would be lower than type II and I (100%). Access classification redounds to determining whether single wire or assembly ...
Maintaining constant blood flow in the face of fluctuations in blood pressure is a critical autoregulatory feature of cerebral arteries. An increase in pressure within the artery lumen causes the vessel to constrict through depolarization and contraction of the encircling smooth muscle cells. This pressure-sensing mechanism involves activation of two types of transient receptor potential (TRP) channels: TRPC6 and TRPM4. We provide evidence that the activation of the γ1 isoform of phospholipase C (PLCγ1) is critical for pressure sensing in cerebral arteries. Inositol 1,4,5-trisphosphate (IP3), generated by PLCγ1 in response to pressure, sensitized IP3 receptors (IP3Rs) to Ca2+ influx mediated by the mechanosensitive TRPC6 channel, synergistically increasing IP3R-mediated Ca2+ release to activate TRPM4 currents, leading to smooth muscle depolarization and constriction of isolated cerebral arteries. Proximity ligation assays demonstrated colocalization of PLCγ1 and TRPC6 with TRPM4, suggesting ...
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Background The contribution of neuroinflammation and specifically mind lymphocyte invasion is recognized as a considerable pathophysiological mechanism after stroke increasingly. and behavioural dysfunction werent decreased 7d after long lasting occlusion from the distal middle cerebral artery (MCAO). Additionally, we didnt measure a substantial decrease in infarct quantity at 24h after 60 min filament-induced MCAO, and didnt see differences in human brain edema between FTY720 and PBS treatment. Analysis of human brain cytokine expression uncovered complex ramifications of FTY720 on postischemic neuroinflammation composed of a substantial reduced amount of postponed proinflammatory cytokine appearance at 3d but an early on boost of IL-1 and IFN- at 24 h after MCAO. Also, serum cytokine degrees of TNF- and IL-6 had been increased in FTY720 treated pets in comparison to handles. Conclusions/Significance In todays study we could actually detect a reduced amount of lymphocyte human brain ...
4.. A patient with a stroke affecting the right middle cerebral artery has difficulty walking, especially over uneven surfaces. Which of the following describes the MOST appropriate initial treatment to improve the patients ability to walk over ...
I had a stroke in November 2009. MRI showed infarc in the back of my brain at lower right. An angigram was done this month that showed that the right cerbral artery was completely blocked while the lef...
Structural diagram of the MCAo surgery region and histological results followed by anocclusion period in rats and mice. (A) Monofilament was inserted into MCA v
Use the MEDIAN function to identify the middle value in a range of cells containing values. If the number of cells being tabulated is even, average the middle two cells. MEDIAN is often contrasted with AVERAGE. Use the MODE function to indicate the value that appears most often within a selected range.
TY - JOUR. T1 - Neutrophil sequestration and the effect of hyperbaric oxygen in a rat model of temporary middle cerebral artery occlusion. AU - Atochin, D. N.. AU - Fisher, D.. AU - Demchenko, I. T.. AU - Thom, S. R.. PY - 2000/12. Y1 - 2000/12. N2 - A rat model of reversible occlusion of the middle cerebral artery was developed to assess the role of neutrophils and prophylactic hyperbaric oxygen (HBO2) on cerebral injury. Blood flow to the ipsilateral caudate putamen nucleus was reduced by approximately 50% during 2 h of arterial occlusion, but unaffected on the contralateral side. Neutrophil accumulation in brain was documented as myeloperoxidase concentration, which was elevated in both ipsilateral and contralateral cerebral hemispheres at 1 and 46 h after occlusion/reperfusion. HBO2 administered before ischemia at 2.8 atm abs for 45 min, as well as antibody-induced neutropenia, reduced neutrophil accumulation, functional neurologic deficits, and cerebral infarct volume. These data ...
TY - JOUR. T1 - Computed tomographic angiography in evaluation of superficial temporal to middle cerebral artery bypass. AU - Besachio, David A.. AU - Ziegler, Jordan. AU - Duncan, Timothy D.. AU - Wanebo, John S.. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Catheter-directed digital subtraction angiography (DSA) is considered the standard for evaluation of superficial temporal to middle cerebral artery (STA-MCA) bypass patency. Few clinical investigations have been performed that evaluate the efficacy of computed tomographic angiography (CTA) in the assessment of extracranial-intracranial bypass. Using multi-detector row CTA, STA-MCA bypass patency was assessed in the initial postoperative period and several months afterward and compared with DSA. No significant difference was identified in the evaluation of graft patency between DSA and CTA. Although multiple modalities exist to evaluate STA-MCA bypass graft patency, the multidetector CTA is widely available and allows for rapid, accurate patency ...
The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respectively (MCAO-D1 and MCAO-D7, n = 8 for each group). The other animals were divided into 3 groups: SHAM-D1 (n = 6), SHAM-D7 (n = 6) and Control (n = 8). Rats performed 4 behavioral tests (the elevated body swing test, the beam balance test, the ladder-climbing test and the forelimb grip force) before the surgery and daily after MCAO-r. H-reflex on triceps brachii was measured before and after isometric exercise. Infarction size and cerebral edema were respectively assessed by histological (Cresyl violet) and MRI measurements at the same time points than H-reflex recordings. Animals with cerebral ischemia showed persistent functional deficits during the ...
Saccular aneurysm growth in a human middle cerebral artery is modeled. The aneurysm growth model was presented in a companion paper by Kroon and Holzapfel ("A Model for Saccular Cerebral Aneurysm Growth by Collagen Fibre Remodelling," J. Theor. Biol., in press) and was assessed there for axisymmetric growth. The aneurysm growth model is now evaluated for a more realistic setting. The middle cerebral artery is modeled as a two-layered cylinder, where the layers correspond to the media and the adventitia. An instant loss of the media in a region of the artery wall initiates the growth of the saccular aneurysm. The aneurysm wall is assumed to be a development of the adventitia of the original healthy artery, and collagen is assumed to be the only load-bearing constituent in the adventitia and in the aneurysm wall. The collagen is organized in a number of distinct layers where fibers in a specific layer are perfectly aligned in a certain fiber direction. The production of new collagen is taken to ...
The territory of the middle cerebral artery is well illustrated with this complete MCA territory infarct. The frequently associated hyperdense artery sign indicative of intra-arterial clot is also evident.
Looking for online definition of cerebral artery in the Medical Dictionary? cerebral artery explanation free. What is cerebral artery? Meaning of cerebral artery medical term. What does cerebral artery mean?
Thrombolysis with intravenous(iv) tissue plasminogen activator (t-PA) is the only effective and approved therapy for acute ischemic stroke. The most frequent cause of ischemic stroke is thrombosis of the middle cerebral artery (MCA). Preliminary in vitro, animal and human studies suggest that ultrasound accelerates thrombolysis induced by t-PA, and recanalization of acute MCA occlusion due to thrombolysis is an independent predictor of good clinical outcome. Thus, insonation of an occluded MCA through the temporal bone in stroke patients who are treated with iv t-PA might enhance recanalization and improve clinical outcome. The present prospective, randomized, controlled multicenter pilot study will investigate the safety and efficacy of continuous 1-hour insonation of the occluded MCA with 2 MHz transcranial color duplex sonography in patients with ischemic stroke treated with iv t-PA within 3 hours after symptom onset. It is planned to randomize 400 patients in 6 Swiss centers during an ...
Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical effect on cerebral haemodynamics by comparing the individual differences in cerebral blood flow velocity (CBFv), vasomotor tone (critical closing pressure- CrCP), vascular bed resistance (resistance-area product- RAP) and cerebral autoregulation (CA) mechanism on healthy subjects and acute ischaemic stroke (AIS) patients from two countries. Participants were pooled from databases in Leicester, United Kingdom (LEI) and São Paulo, Brazil (SP) research centres. Stroke patients admitted within 48 h of ischaemic stroke onset, as well as age- and sex-matched controls were enrolled. Beat-to-beat blood pressure (BP) and bilateral mean CBFv were recorded during 5 min baseline. CrCP and RAP were calculated. CA was quantified using transfer function analysis (TFA) of spontaneous oscillations in arterial BP