A Detailed, Hierarchical Study of Giardia lamblias Ventral Disc Reveals Novel Microtubule-Associated Protein Complexes Journal Article ...
The presence of the microtubule-associated protein (MAP2) in the brain of several species has been investigated by SDS-gel electrophoresis and by radioimmunoassay. This assay had a sensitivity of...
1. Although microtubule-associated protein (MAP) 1B and its phosphorylation have been suggested to be important for synapse formation among cortical neurons, the localization of MAP1B in synapses has ...
TY - JOUR. T1 - The novel microtubule-associated cap-glycine protein cgp1 governs growth, differentiation, and virulence of cryptococcus neoformans. AU - Wanga, Li Li. AU - Lee, Kyung Tae. AU - Jung, Kwang Woo. AU - Lee, Dong Gi. AU - Bahn, Yong-Sun. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Microtubules are involved in mechanical support, cytoplasmic organization, and several cellular processes by interacting with diverse microtubule-associated proteins such as plus-end tracking proteins, motor proteins, and tubulin-folding cofactors. A number of the cytoskeletonassociated proteins (CAPs) contain the CAP-glycine-rich (CAP-Gly) domain, which is evolutionarily conserved and generally considered to bind to a-tubulin to regulate the function of microtubules. However, there has been a dearth of research on CAP-Gly proteins in fungal pathogens, including Cryptococcus neoformans, which is a global cause of fatal meningoencephalitis in immunocompromised patients. In this study, we identified five CAPGly ...
High-resolution microscopic analysis has precisely revealed the control of microtubule dynamics by individual microtubule-associated proteins (MAPs) in vitro. Furthermore, transfection of MAP cDNA into fibroblasts and subsequent analysis using microinjection of caged fluorescein-labeled tubulin and …
In a previous report, we demonstrated that ASAP/MAP9 is a novel microtubule-associated protein required for a proper cell cycle progression [22, 23]. In this paper, we detected homologs in all vertebrate species investigated and potential orthologs in different invertebrates, thus suggesting a requirement of ASAP in higher eukaryotes. The coding sequence and exon-intron structure have been conserved during vertebrate evolution, suggesting that selective constraints are exerted on this gene to maintain its function. These genes are also invariably located in regions syntenic to the human locus, demonstrating common ancestry. Invertebrate and vertebrate ASAP also likely derive from a common ancestor but which evolved independently after the separation of the two clades. This would account for the low level of homology where events such as insertion/deletion or exon shuffling shaped the ASAP gene differently.. The highly N-terminal conserved region 1-98 (Fig. 2C) corresponds to no known conserved ...
In this report, we have investigated the activity of Stu2p in vitro and how this activity relates to its known function in vivo. In contrast to the commonly held belief that members of the Dis1/XMAP215 family of microtubule-associated proteins all act to stabilize microtubules, we find that Stu2p is a microtubule destabilizer. Furthermore, we show that Stu2p is to our knowledge unique among the few known microtubule end-binding proteins in recognizing and preferentially binding microtubule plus ends in vitro. Our hydrodynamic analysis shows that Stu2p, like XMAP215, is an elongated molecule. However, in contrast to XMAP215, which is a monomer in solution (Gard and Kirschner, 1987; Cassimeris et al., 2001), Stu2p seems to be a dimer in vitro and in vivo. The real molecular weight of recombinant and endogenous Stu2p is ∼200 and ∼220 kD, respectively. Given the different nature of yeast extracts and pure proteins, a difference in the derived real molecular weight of 10% is within the ...
Microtubule-Associated Proteins: High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.
We have developed microdensitometer-computer correlation techniques to analyze the arrangement of microtubule arms and bridges (i.e., microtubule-associated proteins [MAPs]). A microdensitometer was used to scan immediately adjacent to the wall of longitudinally sectioned microtubules in positive transparency electron micrographs. Signal enhancement procedures were applied to the digitized densitometer output to produce a binary sequence representing the apparent axial spacing of MAP projections. These enhanced records were analyzed in two ways. (a) Autocorrelograms were formed for each record and correlogram peaks from a group of scans were pooled to construct a peak frequency histogram. (b) Cross-correlation was used to optimize the match between each enhanced record and templates predicted by different models of MAP organization. Seven symmetrical superlattices were considered as well as single axial repeats. The analyses were repeated with randomly generated records to establish confidence ...
An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.
Author: Halpain, Shelley et al.; Genre: Journal Article; Published in Print: 2006-06-30; Keywords: Animals; Evolution, Molecular; Gene Expression Regulation; Humans; Microtubule-Associated Proteins/chemistry/genetics/*physiology; Models, Genetic; Morphogenesis; Nerve Tissue Proteins/chemistry/genetics/*physiology; Nervous System/*metabolism; Phylogeny; Title: The MAP1 family of microtubule-associated proteins
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Microtubule plus-end tracking proteins (+TIPs) are a specialized group of microtubule-associated proteins (MAPs) that preferentially localize to microtubule (MT) plus-ends. This unique localization is thought to be due to +TIP recognition of a unique structural or chemical feature found only at the plus-ends of MTs, such as the GTP- tubulin cap. End-binding proteins (EBs) are considered the master regulators of the +TIP network; however, whether EBs are regulated by other +TIP proteins is not well understood. Therefore, a study of the regulation of EB proteins by CLASPs (CLIP-associated proteins), another family of +TIPs, was undertaken. In cells lacking CLASPs, EB binding at MTs is significantly altered: both EB1 and EB3 relocalized to the MT lattice in addition to their characteristic plus-end localization. This study reveals that CLASPs likely function during MT polymerization to support efficient GTP-hydrolysis and thus promote specific EB plus-end localization. This work establishes CLASPs ...
MAP2 antibody (microtubule-associated protein 2) for IHC-P, WB. Anti-MAP2 pAb (GTX32712) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the
Commander MAP2K1 anticorps monoclonal et polyclonal pour beaucoup dapplications. Selection de fournisseur de qualité pour anti-MAP2K1 anticorps.
The Anti-MAP Therapy Support Group. Some papers on the immunodeficiency hypothesis Crohns as an immune deficiency: from apparent paradox to evolving...
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FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012 ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
MAP4K4兔多克隆抗体(ab69885)可与人样本反应并经WB, ELISA, ICC/IF实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
MAP4K5兔多克隆抗体(ab96551)可与人样本反应并经WB, IHC, ICC/IF实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
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Special note about Community Feature Content. Any content and/or opinions uploaded, expressed or submitted through any Community Feature or any other publicly available section of the Web Site (including password-protected areas), and all articles and responses to questions, other than the content explicitly authorized by the Company, are solely the opinions and responsibility of the person or entity submitting them and do not necessarily reflect the opinions of the Company. By way of example, any recommended or suggested use of products or services available from the Company that is posted through a Community Feature is not a sign of approval or recommendation by the Company. If you choose to follow any such recommendation you do so at your own risk.. Links to Third Party Sites. The Web Site may contain links to other websites on the internet. The Company is not responsible for the content, products, services or practices of any third party websites, including without limitation sites linked to ...
TACC3 and XMAP215 levels affect each others protein stability and localization to MT plus ends. (A, B) Representative Western blots showing levels of TACC3 and
Homo sapiens microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A), transcript variant 2, mRNA. (H00084557-R02) - Products - Abnova
MAP6 - MAP6 (untagged)-Human microtubule-associated protein 6 (MAP6), transcript variant 2 available for purchase from OriGene - Your Gene Company.
MAP1A - MAP1A (untagged)-ORIGENE UNIQUE VARIANT 1 of Human microtubule-associated protein 1A (MAP1A) available for purchase from OriGene - Your Gene Company.
LC3B antibody (microtubule-associated protein 1 light chain 3 beta) for FACS, ICC/IF, IHC-P, IP, WB. Anti-LC3B pAb (GTX127375) is tested in Human, Mouse, Pig, Rat samples. 100% Ab-Assurance.
Sánchez, C., P. Tompa, K. Szücs, P. Friedrich, and J. Avila, Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule-associated protein 2., Eur J Biochem, vol. 241, issue 3, pp. 765-71, 1996 Nov 1. ...
Plasmid pBABE-puro mCherry-EGFP-LC3B from Dr. Jayanta Debnaths lab contains the insert microtubule-associated protein 1 light chain 3 beta and is published in EMBO Rep. 2009 Feb;10(2):173-9. doi: 10.1038/embor.2008.238. Epub 2009 Jan 16. This plasmid is available through Addgene.
Complete information for CLASP2 gene (Protein Coding), Cytoplasmic Linker Associated Protein 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSP 1 - 70 NTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGST 71 - 140 ESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYEPDSVL 141 - 210 PLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLI 211 - 280 IISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSN 281 - 350 TPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF 351 - 420 VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHN 421 - 490 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVIL 491 - 560 RQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPL 561 - 630 VRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVE 631 - 700 IRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGS 701 - 770 PEIKRFSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE 771 - 840 ...
According to the University of the West of England, a literature map is one that maps literature or literary concepts based on connections and associations. Much like other maps, a literature map is...
The [Map->Values] tag returns an array of values from the map. This tag is useful if the values of a map need to be inspected without their associated keys.If the map contains no values then an empty array is returned.
TY - JOUR. T1 - UNC-45A is a novel microtubule-associated protein and regulator of paclitaxel sensitivity in ovarian cancer cells. AU - Mooneyham, Ashley. AU - Iizuka, Yoshie. AU - Yang, Qing. AU - Coombes, Courtney. AU - McClellan, Mark. AU - Shridhar, Vijayalakshmi. AU - Emmings, Edith. AU - Shetty, Mihir. AU - Chen, Liqiang. AU - Ai, Teng. AU - Meints, Joyce. AU - Lee, Michael K.. AU - Gardner, Melissa. AU - Bazzaro, Martina. PY - 2019/2/1. Y1 - 2019/2/1. N2 - UNC-45A, a highly conserved member of the UCS (UNC45A/CRO1/SHE4P) protein family of cochaperones, plays an important role in regulating cytoskeletal-associated functions in invertebrates and mammalian cells, including cytokinesis, exocytosis, cell motility, and neuronal development. Here, for the first time, UNC-45A is demonstrated to function as a mitotic spindle-associated protein that destabilizes microtubules (MT) activity. Using in vitro biophysical reconstitution and total internal reflection fluorescence microscopy analysis, we ...
Controlling microtubule dynamics and spatial organization is a fundamental requirement of eukaryotic cell function. Members of the ORBIT/MAST/CLASP family of microtubule-associated proteins associate with the plus ends of microtubules, where they promote the addition of tubulin subunits into attached kinetochore fibers during mitosis and stabilize microtubules in the vicinity of the plasma membrane during interphase. To date, nothing is known about their function in plants. Here, we show that the Arabidopsis thaliana CLASP protein is a microtubule-associated protein that is involved in both cell division and cell expansion. Green fluorescent protein-CLASP localizes along the full length of microtubules and shows enrichment at growing plus ends. Our analysis suggests that CLASP promotes microtubule stability. clasp-1 T-DNA insertion mutants are hypersensitive to microtubule-destabilizing drugs and exhibit more sparsely populated, yet well ordered, root cortical microtubule arrays. Overexpression ...
During animal development cellular differentiation is often preceded by an asymmetric cell division whose polarity is determined by the orientation of the mitotic spindle. In the fruit fly, Drosophila melanogaster, the oocyte differentiates in a 16-cell syncytium that arises from a cystoblast which undergoes 4 synchronous divisions with incomplete cytokinesis. During these divisions, spindle orientation is highly ordered and is thought to impart a polarity to the cyst that is necessary for the subsequent differentiation of the oocyte. Using mutations in the Drosophila cytoplasmic dynein heavy chain gene, Dhc64C, we show that cytoplasmic dynein is required at two stages of oogenesis. Early in oogenesis, dynein mutations disrupt spindle orientation in dividing cysts and block oocyte determination. The localization of dynein in mitotic cysts suggests spindle orientation is mediated by the microtubule motor cytoplasmic dynein. Later in oogenesis, dynein function is necessary for proper ...
Autophagy has been referred to as a double-edged sword in tumorigenesis and tumor progression. Emerging evidence suggests that pharmacological modulation of autophagy is a promising therapeutic strategy for cancer. However, few autophagy-modulating compounds are currently approved for clinical use in humans. Matrine is a natural compound extracted from traditional Chinese medicine that is widely used for treatment of a variety of diseases without any obvious side effects. Recently, matrine has been reported to induce autophagy and autophagic cell death in cancer cells, although the underlying mechanisms have yet to be elucidated. Here, we systematically examined the autophagic events induced by matrine in SGC7901 cells. The accumulation of autophagic vacuoles in matrine-treated cells was verified by the conversion of microtubule-associated protein light chain 3 as well as confocal and transmission electron microscopy. Furthermore, we demonstrated that matrine blocked autophagic degradation by ...
The divergence in the relative importance of EB1 compared with EB3 and in their role in microtubule stabilization might then be at least partially reconciled by considering experimental differences: the isolation of permanently knocked down cell lines (this work) compared with transient transfections (Straube and Merdes, 2007). Given the usual timeline of C2 culture and differentiation (2 days in GM and then switch to FM), transient transfection might not be able to knock down EB1 fast enough to prevent any effect it might have in early differentiation. Microtubule stabilization, in particular, is an early event in muscle differentiation (Gundersen et al., 1989) and could become immune to EB knockdown if it initiates an irreversible cascade of events (Eng et al., 2006; Ciani and Salinas, 2007; Onishi et al., 2007). Consistently with this explanation, when we overexpressed EB1 constructs transiently, we did not observe any effects on glu-tubulin levels (data not shown).. Elongation of myoblasts, ...
Get this from a library! Analyse des tumorrelevanten proteins survivin : molekulare charakterisierung der dimerisierung. [Cecilia Vallet; Shirley Knauer] -- Cecilia Vallet untersucht, wie der Wechsel zwischen der monomeren und der dimeren Form des Proteins Survivin reguliert ist. Survivin ist in nahezu allen malignen Tumorerkrankungen überexprimiert und ...
The apoptosis inhibitor protein survivin is overexpressed in many tumors, making it a candidate target molecule for various forms of immunotherapy. To explore survivin as a target antigen for adoptive T cell therapy using lymphocytes expressing survivin-specific transgenic T cell receptors (Tg-TCRs), we isolated HLA-A2-allorestricted survivin-specific T cells with high functional avidity. Lymphocytes expressing Tg-TCRs were derived from these T cells and specifically recognized HLA-A2+ survivin+ tumor cells. Surprisingly, HLA-A2+ but not HLA-A2- lymphocytes expressing Tg-TCRs underwent extensive apoptosis over time. This demise was caused by HLA-A2-restricted fratricide that occurred due to survivin expression in lymphocytes, which created ligands for Tg-TCR recognition. Therefore, survivin-specific TCR gene therapy would be limited to application in HLA-A2-mismatched stem cell transplantation. We also noted that lymphocytes that expressed survivin-specific Tg-TCRs killed T cell clones of ...
Microtubules (MTs) are filamentous structures found throughout the cytoplasm of eukaryotic cells. They are polymers of tubulin that are involved in maintaining the structural integrity and plasticity of cells as well as the internal structures of cilia and flagella. Microtubules are also essential in several key cellular processes such as cell division and intracellular transport.. Proteins that accumulate at the ends of growing microtubules, known as MT plus end-tracking proteins, play an important role in regulating the dynamics and organization of the organelle. The SLAIN2 gene encodes one such MT plus end-tracking protein. This protein is targeted to microtubule tips by interacting with End-Binding proteins through its C-terminal domain. It is involved in cytoplasmic microtubule organization and nucleation. Through its N-terminal domain, it binds with the polymerase ch-TOG, recruiting it to the microtubule plus ends and thus ensuring microtubule elongation. ...
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In this study, we have positioned the survivin pathway as a novel regulatory mechanism of mitochondrial-dependent apoptosis. Secondly, we have shown that targeting survivin exerts anticancer activity by combining enhanced tumor cell apoptosis with suppression of tumor-associated angiogenesis in vivo.. Despite the considerable interest in survivin for its bifunctional role in cell viability and regulation of mitosis (10) and the dramatic exploitation of this pathway in human tumors (12) , critical aspects of the survivin pathway have remained elusive. In particular, how survivin couples to the cell death machinery has not been conclusively elucidated. Earlier claims that this may involve suppression of caspase catalytic activity (30) , similar to other antiapoptotic IAP proteins (9) , were disputed on both functional (31) and structural grounds (32) . More recent arguments favored an indirect model of survivin-mediated cell viability, in which interference with survivin expression/function ...
A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell responses in the intestine. Selective deletion of Atg16l1 in T cells in mice resulted in spontaneous intestinal inflammation that was characterized by aberrant type 2 responses to dietary and microbiota antigens, and by a loss of Foxp3(+) Treg cells. Specific ablation of Atg16l1 in Foxp3(+) Treg cells in mice demonstrated that autophagy directly promotes their survival and metabolic adaptation in the intestine. Moreover, we also identify an unexpected role for autophagy in directly limiting mucosal TH2 cell expansion. These findings provide new insights into the reciprocal control of distinct intestinal TH cell responses by autophagy, with important implications for understanding and treatment of chronic
目的 系统评价卵巢癌组织中 Survivin mRNA 表达与卵巢癌的相关性。 方法 计算机检索 PubMed、The Cochrane Library(2016 年 11 期)、CBM、CNKI、VIP 和 WanFang Data 数据库,搜集公开发表的所有关于 Survivin mRNA 表达与卵巢癌临床病理特征关系的病例-对照研究,检索时限均为从建库至 2016 年 11 月。由 2 位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.2 软件进行 Meta 分析。 结果 共纳入 10 个病例-对照研究。Meta 分析结果显示:Survivin mRNA 表达在卵巢癌组高于对照组[OR=24.63,95% CI(13.44,45.15),P|0.000 01],其在低分化组表达高于高分化组[OR=3.69,95% CI(2.29,5.93),P|0.000 01],在临床 Ⅲ~Ⅳ 期组表达高于临床 Ⅰ~Ⅱ 期组[OR=4.76,95% CI(2.99,7.57),P|0.000 01]。但其表达与有无淋巴结转移
目的 系统评价卵巢癌组织中 Survivin mRNA 表达与卵巢癌的相关性。 方法 计算机检索 PubMed、The Cochrane Library(2016 年 11 期)、CBM、CNKI、VIP 和 WanFang Data 数据库,搜集公开发表的所有关于 Survivin mRNA 表达与卵巢癌临床病理特征关系的病例-对照研究,检索时限均为从建库至 2016 年 11 月。由 2 位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.2 软件进行 Meta 分析。 结果 共纳入 10 个病例-对照研究。Meta 分析结果显示:Survivin mRNA 表达在卵巢癌组高于对照组[OR=24.63,95% CI(13.44,45.15),P|0.000 01],其在低分化组表达高于高分化组[OR=3.69,95% CI(2.29,5.93),P|0.000 01],在临床 Ⅲ~Ⅳ 期组表达高于临床 Ⅰ~Ⅱ 期组[OR=4.76,95% CI(2.99,7.57),P|0.000 01]。但其表达与有无淋巴结转移
Survivin is a novel member of the IAP family of proteins with a potential dual role in apoptosis inhibition and regulation of mitosis. In addition, survivin is implicated in the regulation of the mitotic spindle checkpoint and the promotion of angiogenesis, and chemoresistance. Survivin is up-regulated in almost all cancers, including colon cancer, but has low or no expression in most normal, differentiated adult tissues. Expression of survivin in cancer cells has been shown to promote tumorigenesis. Besides, the expression levels of survivin strongly correlate with the proliferative activity of the tumours indicating a possible role in cell cycle regulation and cancer progression.. However, the effect of a novel chemotherapy such as oxaliplatin and vinflunine on survivin expression has been not well characterized yet. Therefore, the effects of oxaliplatin and vinflunine treatment on survivin protein expression in lymphocytes from colon cancer patients against healthy volunteers were ...
Comments, concepts and statistics about Upregulation of autophagy-related gene 5 protects dopaminergic neurons in a zebrafish model of Parkinsons disease.