The nanofiber plasmon effect on the two-photon polymerization (2PP) induced by a femtosecond laser is reported for the first time in this paper. The nanofibers were generated using a femtosecond laser, which was also used to construct microfeatures through two-photon polymerization of a nanofiber dispersed polymer resin. Nanofiber plasmon resonant effect greatly enhances local field intensities, resulting in increased particle scattering cross sections. This leads to a drastic enhancement of two-photon-like absorption processes, allowing much lower incident radiation intensities to be used. The huge enhancements in local field intensity due to nanofiber plasmon resonances have been shown to lower the required intensity for 2PP by factors of 10 or more.. ...
Polymers have assumed the leading role as substrate materials for microfluidic devices in recent years. They offer a broad range of material parameters as well as material and surface chemical properties which enable microscopic design features that cannot be realised by any other class of materials. A similar range of fabrication technologies exist to generate microfluidic devices from these materials. This review will introduce the currently relevant microfabrication technologies such as replication methods like hot embossing, injection molding, microthermoforming and casting as well as photodefining methods like lithography and laser ablation for microfluidic systems and discuss academic and industrial considerations for their use. A section on back-end processing completes the overview. ...
Microfabrication Techniques tutorial of Microfluidics course by Prof Ashis Kumar Sen of IIT Madras. You can download the course for FREE !
Two-photon polymerization (TPP) is an enabling technology that allows fast prototyping of parts with sub-100 nm resolution. Due to its ability to fabricate microstructures with arbitrary three-dimensional geometries, TPP has been employed in diverse fields such as nanophotonics, microelectronics, microelectromechanical systems, and microfluidics. However, no information is available to date that microscopically correlates the experimental conditions used in TPP with the properties of the ultimate microstructure. We present a study where the distribution of polymer cross-linking in three-dimensional microstructures fabricated by TPP is visualized by means of coherent anti-Stokes Raman scattering (CARS) microscopy. The characterization of the microstructures based on the acquired images permits rational optimization of the TPP process
Application of the two-photon polymerization (2PP) technique for the fabrication of submicron-size relief of radial binary diffractive optical elements (DOEs) is studied. Binary DOEs for the formation of special longitudinal intensity distribution (axial light segment) are realized. Interferometric investigations of the diffractive relief produced by the 2PP-technique and investigations of optical properties of the formed elements are presented. Results of computer simulations are in good agreement with the experimental observations.. ©2010 Optical Society of America. Full Article , PDF Article ...
We present here an innovative three dimensional microfabrication technology that will serve as a vehicle to enable vascularized bioreactors for in vitro tissue culture. The core of our microfabrication technology is a high-resolution projection micro stereo lithography (PuSL) using a spatial light modulator as the dynamic mask. This unique technology provides a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly anhydride and poly(ethylene glycol) bioreactors are demonstrated with PuSL technology. The precisely controlled vessel density (|100/mm2) in the polymer matrix and enhanced transport of nutrient and oxygen through advection represent the key advantages of the microfabricated bioreactors to the traditional foam based scaffolds.|br| |br|Further developments of this 3D microfabricated bioreactors are expected to have direct impact on applications such as analyte controlled and modulated drug and protein delivery, drug targeting, tissue engineering, and micro- or
Medical applications are driving robust growth in the global micromolding sector, according to a new market report from TechNavio (Elmhurst, IL). The medical segment of the micromolding market is expected to surpass $234 million in revenue by 2018, with overall micromolding growing globally by a compound annual growth rate of 13.5% between 2014 and 2018.
Abstract. Microtechnology has changed our world since the last century, when silicon microelectronics revolutionized sensor, control and communication areas, with applications extending from domotics to automotive, and from security to biomedicine. The present century, however, is also seeing an accelerating pace of innovation in glassy materials; as an example, glass-ceramics, which successfully combine the properties of an amorphous matrix with those of micro- or nano-crystals, offer a very high flexibility of design to chemists, physicists and engineers, who can conceive and implement advanced microdevices. In a very similar way, the synthesis of glassy polymers in a very wide range of chemical structures offers unprecedented potential of applications. The contemporary availability of microfabrication technologies, such as direct laser writing or 3D printing, which add to the most common processes (deposition, lithography and etching), facilitates the development of novel or advanced ...
This paper presents an analytical modeling and laser micromachining technique of microchannel and micro-structures for bio-devices manufacturing and biomedical applications. The ablation of the laser micromachining with direct-write method has been modeled and simulated for micro-channels or microstructures in bio-devices microfabrication. In this paper, the analytical model was adapted from the linear function for beam propagation in our previous research by using the Gaussian function to improve modeling accuracy. Basically, the new laser ablation model based on Gaussian distribution, beam propagation modeling and Beers law were used to formulate and model the laser ablation phenomenon. After the simulation with MATLAB programming, the actual experiment on laser micromachining has been conducted to compare the simulated results with the actual ones. Finally, the purposed modeling technique can be applied in the surface error analysis and biomedical applications. The example case in this paper ...
Looking for microfabrication? Find out information about microfabrication. The technology of fabricating microsystems from silicon wafers, using standard semiconductor process technologies in combination with specially developed... Explanation of microfabrication
The work described in this dissertation was conducted in the interdisciplinary research environment of the Clemson University Institute for Biological Interfaces of Engineering. A note at the beginning of each chapter acknowledges, as relevant, collaborating doctoral students and reminds the reader where work from each chapter has been presented or published. The overall goal of this work was to develop tissue engineered test system methodologies to allow the study of mammary cell interactions in vitro. The background, as described in Chapter 1, was published in part in Philosophical Transactions of the Royal Society A in 2010. The studies were designed to encompass both microfabrication technology as well as traditional 3D gel-based macrofabrication techniques, both of which will ultimately be necessary to design and fabricate biologically relevant 3D composite breast tissue cultures. The first step was to assess the effectiveness of microfabrication technology (a custom inkjet bioprinter) to eject
The specification describes a process for fabricating semiconductor devices and circuits in which lateral geometry dimensions determining the performance level of the device or circuit are extremely small. In this process electron beam microfabrication techniques are used to define these extremely small dimensions. The complete fabrication process uses standard photolithography for the definition of some of the device geometry and mask patterns, and partitioning of pattern definition between electron beam microfabrication and standard photolithography is utilized according to pattern resolution requirements, and is optimized for the highest yield-throughout product.
0092] Microfabricated microreactors (MFMR) were designed and developed using established and novel microfabrication techniques. The process was adopted for the steps, to create circular passages, that resemble those of recent microfabrication of passages in various substrates (Bu et al., "A New Masking Technology for Deep Glass Etching and Its Microfluidic Application," Sens. Actuator A-Phys. 115:476-82 (2004); Grosse et al., "Deep Wet Etching of Fused Silica Glass for Hollow Capillary Optical Leaky Waveguides in Microfluidic Devices," Journal of Micromechanics and Microengineering 11:257-62 (2001); Iliescu et al., "On the Wet Etching of Pyrex Glass," Sens. Actuator A-Phys. 143:154-61 (2008); Iliescu et al., "Characterization of Masking Layers for Deep Wet Etching of Glass in an Improved HF/HCl Solution," Surf. Coat. Technol. 198:314-8 (2005); Iliescu et al., "Strategies in Deep Wet Etching of Pyrex glass," Sens. Actuator A-Phys. 133:395-400 (2007); and U.S. Pat. No. 5,575,929 to Yu et al., ...
This dissertation developed novel microfabrication techniques of conductive polymer nanocomposite and utilized this material as a functional element for various physical sensor applications. Microstructures of nanocomposite were realized through novel microcontact printing and laser ablation assisted micropatterning processes. Prototype devices including large-strain strain sensor and highly-sensitive pressure sensor were demonstrated showing distinct advantages over existing technologies. The polymer nanocomposite used in this work comprised elastomer poly(dimexylsiloxane) (PDMS) as polymer matrix and multi-walled carbon nananotubes (MWCNTs) as a conductive nanofiller. To achieve uniform distribution of carbon nanotubes within the polymer, an optimized dispersion process was developed, featuring a strong organic solvent-chloroform, which dissolved PDMS base polymer easily and allowed monodispersion of MWCNTs. Following material preparation, three novel approaches were employed to pattern
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Four π-expanded α,β-unsaturated 1,3-diketones have been prepared via attaching strong electron-donating and electron-withdrawing groups at positions 9 and 10 of the anthracene scaffold. The strategic incorporation of (C12H25)2N groups at the periphery of these D-π-A molecules resulted in dyes with excellent Celebrating 175 years of the Royal Society of Chemistry
Tufts Microfabrication and Nanofabrication Facility (TMNF): Microtechnology, Nanotechnology, MEMS, and NEMS at Tufts School of Engineering
Tufts Microfabrication and Nanofabrication Facility (TMNF): Microtechnology, Nanotechnology, MEMS, and NEMS at Tufts School of Engineering
In this paper, a simple fabrication process for SU-8 in-plane micro electro-mechanical systems (MEMS) structures, called “border-bulk micromachining”, is introduced. It aims to enhance the potential of SU-8 MEMS structures for applications such as low-cost/disposable microsystems and wearable MEMS. The fabrication process is robust and uses only four processing steps to fabricate SU-8 in-plane MEMS structures, simplifying the fabrication flow in comparison with other reported attempts. The whole fabrication process has been implemented on copper-polyimide composites. A new processing method enables the direct, laser-based micromachining of polyimide in a practical way, bringing in extra processing safety and simplicity. After forming the polymeric in-plane MEMS structures through SU-8 lithography, a copper wet etching masked by the SU-8 structure layers is carried out. After the wet etching, fabricated in-plane MEMS structures are suspended within an open window on the substrate, similar to
The UAlbany CNSE is the first college in the world dedicated to research, development, education, and deployment in the emerging disciplines of nanoscience, nanoengineering, nanobioscience, and nanoeconomics. In May 2007, it was ranked as the worlds number one college for nanotechnology and microtechnology in the Annual College Ranking by Small Times magazine. CNSEs Albany NanoTech complex is the most advanced research enterprise of its kind at any university in the world: a $4.2 billion, 450,000-square-foot complex that attracts corporate partners from around the world and offers students a one-of-a-kind academic experience. The UAlbany NanoCollege houses the only fully-integrated, 300mm wafer, computer chip pilot prototyping and demonstration line within 65,000 square feet of Class 1 capable cleanrooms. More than 2,000 scientists, researchers, engineers, students, and faculty work on site at CNSEs Albany NanoTech complex, from companies including IBM, AMD, SEMATECH, Toshiba, ASML, Applied ...
The development of precise microdevices can be applied to the reconstruction of in vitro human microenvironmental systems with biomimetic physiological conditions that have highly tunable spatial and temporal features. Organ-on-a-chip can emulate human physiological functions, particularly at the organ level, as well as its specific roles in the body. Due to the complexity of the structure of the central nervous system and its intercellular interaction, there remains an urgent need for the development of human brain or nervous system models. Thus, various microdevice models have been proposed to mimic actual human brain physiology, which can be categorized as nervous system-on-a-chip. Nervous system-on-a-chip platforms can prove to be promising technologies, through the application of their biomimetic features to the etiology of neurodegenerative diseases. This article reviews the microdevices for nervous system-on-a-chip platform incorporated with neurobiology and microtechnology, including
Ordinary cancer cells are seen in the centre of the lab on a chip device, which is attracting cancer stem cells towards the electrode, performing real time sorting. As the first stage has been achieved in a new European research collaboration to combat two of the most aggressive brain cancers (www.sumcastec.eu), academic and industry participants are meeting at Bangor University this week (11-12 July) to discuss the next steps.. Bangor University and the industry partner Creo Medical are additionally co-hosting a technical workshop entitled "EM field interaction with biological tissues for cancer and regenerative medicine" (13th July, Pontio, room PL5, 8:30-17:30) which is open to the public and will showcase the projects latest achievements along with exciting research from synergistic and related initiatives. The SUMCASTEC projects combines the expertise of leading biologists and electronic engineers to develop innovative microtechnology devices that will ultimately be able to identify and ...
This paper aims to discuss and review developments in plasma surface modification techniques which have been seen over the past few years, with particular emphasis on low energy or soft plasma assisted surface polymerisation processes. While early work focussed mainly on protective coatings and surface activation, the advancements in microtechnology in the 1980s followed by those in nanotechnology in the 1990s and 2000s have resulted in new challenges for surface processing and surface modification processes. The latest advancements in plasma polymer chemistry have shown tremendous potential for the synthesis of reasonably well defined molecular structures with a high retention of functional groups. Some of the latest achievements and newest insights into the behaviour of such deposits in a liquid environment will be discussed, with a particular focus on bionanotechnological applications. Utilising novel approaches in surface and interface analysis, it will be shown that plasma polymers can be ...
The Department of Microtechnology and Nanoscience - MC2 has gathered several research areas together with competent and talented researchers to form a unique environment. This crossdisciplinary strategy provides for interesting collaborations and serves as a driving force for innovations and breakth
The following companies have participated in our gap grant program and benefited from a $50,000-250,000 collaborative proof-of-concept project award. Many of the resulting products are on market now or are on their way there, making them ripe for investment, partnership and supplier opportunities.. They represent the best and brightest in nanoscience and microtechnology research in Oregon-entrepreneurs selected because of their companies high-growth potential.. ...
Microtechnology has created self-powered roller blades that allow a rider to rip along at blistering speeds, roar up walls and fly to incredible heights. And now AIR TECK (A-T) has become the new rage with all of the gangs. Ikki got the dickens kicked out of him by a roller-blade gang and the four sisters that he is staying with are not going to allow him to forget it. Of the four sisters, it falls upon fourteen-year-old Ringo to be responsible for looking after their trouble-some adopted little brother whom they have nicknamed baby-face. When Ikki finds out that the girls are part of an A-T gang called the sleeping forest, he borrows one of their skates and rides off into the night vowing to learn to ride . A chance encounter introduces him to a cute roller-blade girl. Ikki follows her to a Stormrider (AT gang) gathering and learns that she is called Simca. Simca really seems to take a fancy for him (or perhaps she really enjoys teasing him), but when his sisters (most specifically Ringo) ...
UCSF and Zcube have entered into a new agreement to license UCSF-developed microtechnology and support early research into new ways to deliver oral medications directly to a targeted site in the body.
Creating in vitro microenvironments for the study of important biological processes, examples of which include chemotaxis, haptotaxis, axonal guidance and angiogenesis, has been a relevant research focus for many years. Microfabrication techniques involving soft lithography, microfluidic devices and direct-write assembly can be used to create such microenvironments. Soft lithography techniques, which typically include microcontact printing and decal transfer, rely on elastomeric molds, stamps or flexible photomasks to create patterns on or transfer patterns to, an underlying surface; these molds or stamps themselves have also been used for study. In microfluidic devices, small fluid volumes are transported through microchannels via gravity or pressure-driven methods. Biological studies are either conducted within the gradients maintained by laminar flow through the microchannels, or on the residually patterned underlying rigid surface, created via physi-adsorption or through chemical ...
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Series Preface xiii. Preface xv. Acknowledgements xvii. Notation xix. About the Companion Website xxiii. 1 Introduction 1. 1.1 Microsystems 1. 1.2 Microsystems Fabrication 3. 1.3 Mechanics in Microsystems 5. 1.4 Book Contents 6. References 7. Part I Fundamentals 9. 2 Fundamentals of Mechanics and Coupled Problems 11. 2.1 Introduction 11. 2.2 Kinematics and Dynamics of Material Points and Rigid Bodies 12. 2.2.1 Basic Notions of Kinematics and Motion Composition 12. 2.2.2 Basic Notions of Dynamics and Relative Dynamics 15. 2.2.3 One-Degree-of-Freedom Oscillator 17. 2.2.4 Rigid-Body Kinematics and Dynamics 22. 2.3 Solid Mechanics 25. 2.3.1 Linear Elastic Problem for Deformable Solids 26. 2.3.2 Linear Elastic Problem for Beams 35. 2.4 Fluid Mechanics 43. 2.4.1 Navier-Stokes Equations 43. 2.4.2 Fluid-Structure Interaction 48. 2.5 Electrostatics and Electromechanics 49. 2.5.1 Basic Notions of Electrostatics 49. 2.5.2 Simple Electromechanical Problem 54. 2.5.3 General Electromechanical Coupled Problem ...
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A microactuator device includes a base with at least one electrode pad and a permeation membrane. Permeation membrane is typically a water-permeable membrane that is able to deform by applying an electric charge to the electrode pad. The actuator device can be incorporated into valve assembly to open and close the valve. The valve assembly can have a reciprocating valve member operated by the deforming of the water-permeable member. Alternatively, the valve assembly can have an opening positioned to cooperate with the water-permeable membrane so that the deformation of the membrane closes the opening.
Dr. Maeve Duffy, graduated from the National University of Ireland, Galway in 1997 with a Ph.D. (Electronic Engineering) in the area of power electronics. From 1997 - 2001, she worked with the PEI Technologies group at NMRC (now Tyndall Institute), Cork. While there, she participated in several EU and industry funded projects; her work involved the development of circuit models for integrated magnetic components formed in different microfabrication technologies ...
Donald E. Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Childrens Hospital, and Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences. He received his B.A., M.A., M.Phil., M.D. and Ph.D. from Yale University. Dr. Ingber is a founder of the emerging field of biologically inspired engineering, and at the Wyss Institute, he oversees a multifaceted effort to identify the mechanisms that living organisms use to self-assemble from molecules and cells, and to apply these design principles to develop advanced materials and devices for healthcare and to improve sustainability. He also leads the Biomimetic Microsystems platform in which microfabrication techniques from the computer industry are used to build functional circuits with living cells as components. His most recent innovation is a technology for building tiny, ...
Biomimetic models of microvasculature could enable assays of complex cellular behavior at the capillary-level, and enable efficient nutrient perfusion for the maintenance of tissues. However, existing three-dimensional printing methods for generating perfusable microvasculature with have insufficient resolution to recapitulate the microscale geometry of capillaries. Here, we present a collection of multiphoton microfabrication methods that enable the production of precise, three-dimensional, branched microvascular networks in collagen. When endothelial cells are added to the channels, they form perfusable lumens with diameters as small as 10 μm. Using a similar photochemistry, we also demonstrate the micropatterning of proteins embedded in microfabricated collagen scaffolds, producing hybrid scaffolds with both defined microarchitecture with integrated gradients of chemical cues. We provide examples for how these hybrid microfabricated scaffolds could be used in angiogenesis and cell homing ...
Introduction: Native tissues consist of several cell types which are embedded in a matrix with a distinct architecture. For the in vitro generation of a functional 3D tissue, a technique for the directed deposition of cells into predefined scaffolds is a prerequisite. Materials and methods: Two-photon polymerization (2PP) was applied to generate a hexagonal, structured scaffold (2 mm in diameter, 200 m in height) from poly ethylene glycol diacrylate (PEGda) monomers and a photoinitiator (Irgacure 369, Ciba). Using Laser Induced Forward Transfer (LIFT) droplets of a hydrogel suspension of endothelial (EC) or smooth muscle- like (SMC) cells (~20 cell/droplet) were propelled selectively into the target cylinders of the scaffold. Layer-by-layer one droplet was put on the top of another until the cylinder was completely filled. The deposition of the differently pre-stained ECs and SMCs was monitored directly after the LIFT- process by fluorescence microscopy. Results: Fluorescence microscopic ...
The basic setup of inclined UV exposure has conventional UV source, a contact stage, and a tilting stage. Plus, we place a photomask and a photoresist coated substrate between the upper and lower plates of the contact stage, and it is fixed by pushing up the lower plate with a screw. Then, we can expose the photoresist to the inclined UV. An example of the fabrication process: Su-8 is a negative thick photoresist, which used in novel 3D micro fabrication method with inclined/rotated UV lithography. During the process, we coat SU-8 50 on a silicon wafer with a thickness of about 100ųm. Then, soft bake the resist on a 65 °C hot plate for 10 minutes and on a 95 °C plate for 30 minutes. It is contacted with a photomask using the contact stage. This stage, is leaned against the tilting stage and the resist is exposed to the UV. The dose of 365 nm UV is 500mJ/cm². After the exposure, the resist is post-expoure baked on a 65 °C hot plate for 3 minutes and on a 95 °C plate for 10 minutes. In the ...
THUNDER Imager eliminates the out-of-focus blur that clouds the view of thick samples when using camera-based fluorescence microscopes. This performance advantage is achieved with a new opto-digital method created by Leica Microsystems called Computational Clearing. Currently unique to the market, the new technology deployed in THUNDER Imagers makes visualization and analysis of large volume, thick specimens ideal for many biomedical applications where they are required, including regenerative medicine, cancer, and stem cell research to decode 3D biology in real time. ...
Focused on helping life sciences companies effectively manage the growing volume and complexity of their data, Sun Microsystems, Inc. today announced it is teaming with Acero, Inc. to provide a knowledge and data management platform for genomic-based drug
Demonstrating Suns ongoing commitment to eHealth, the B2B-enabled EMPI solution, a part of the Sun Java Enterprise System, provides enterprise-class infrastructure software for hospitals, insurers and other health care organisations who are sharing patient data across organisations. The debut of iPACS and uPACS provides an integrated platform that enables PACS OEMs and Systems Integrators to rapidly build and implement competitive, complete eHealth solutions.. "Sharing patient data allows greater efficiency for medical billing and clinical record document sharing processes", stated Joerg Schwarz, director of Healthcare and Life Sciences, Sun Microsystems. "By linking patient data and records across a network of providers and insurers, Sun technology is helping to make it possible for doctors, nurses and other care-givers to have complete patient information at their fingertips to provide the best possible care. Further, helping our PACS vendors to reduce capital costs and improve scalability by ...
The DFC3000 G grayscale USB 3.0 microscope camera from Leica Microsystems features a passive cooling architecture and correlated pixel double-sampling for clear fluorescence signals and low background noise in routine fluorescence applications.
A new digital color CCD camera from Leica Microsystems is suited to fluorescence and brightfield microscopy applications. The DFC7000 T has
Leica Microsystems introduces the Leica HyD SMD universal hybrid photodetector with superior characteristics for single molecule detection, which allows precise measurement of concentration and observation of fast cellular processes.
Leica Microsystems has launched FluoScout, an online tool that allows users of fluorescence microscopes to determine the optimal filter cube or filter
Columbia, MD (PRWEB) January 25, 2008 -- Prism Microsystems Inc., a pioneer in event log management technology, today announced that EventTracker 6.0, the
Our interview partner on the topic of Pioneering is Prf. Stefan Hell, a scientific member of the Max Planck Society and director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, where he heads the Department of Nanobiophotonics. In addition to further chairs and memberships, he is also head of the High resolution Optical Microscopy research group, a partnership department of the German Cancer Research Center (DFKZ ...
As a supplier of components, we are not required to assess regulatory requirements (such as the European RoHS Directive (2011/65/EU) - hereinafter referred to as RoHS) that apply to finished product. Please note further that product may contain small amounts of lead. Therefore, we cannot make representations, warranties or indemnities regarding the complete absence of lead in the finished product. You will note that, if there is sufficient volume and the above referenced product is not below RoHS allowable thresholds, we are prepared to discuss making a product listed by Allegro that is below RoHS allowable thresholds. Allegro MicroSystems, LLC is a cooperative environmental supplier who fully supports global environmental initiatives. We value our customer relationships and are committed to provide the highest levels of quality standards. Geoffrey H. DesRosiers ...
As a supplier of components, we are not required to assess regulatory requirements (such as the European RoHS Directive (2011/65/EU) - hereinafter referred to as RoHS) that apply to finished product. Please note further that product may contain small amounts of lead. Therefore, we cannot make representations, warranties or indemnities regarding the complete absence of lead in the finished product. You will note that, if there is sufficient volume and the above referenced product is not below RoHS allowable thresholds, we are prepared to discuss making a product listed by Allegro that is below RoHS allowable thresholds. Allegro MicroSystems, LLC is a cooperative environmental supplier who fully supports global environmental initiatives. We value our customer relationships and are committed to provide the highest levels of quality standards. Geoffrey H. DesRosiers ...