TY - JOUR. T1 - Simultaneous detection and quantification of six equine cytokines in plasma using a fluorescent microsphere immunoassay (FMIA). AU - Hall, SA. AU - Stucke, D. AU - Morrone, B. AU - Lebelt, D. AU - Zanella, AJ. N1 - 1023306. PY - 2015. Y1 - 2015. N2 - Cytokines are cell signalling proteins that mediate a number of different physiological responses. They are also biomarkers for inflammatory conditions and potential diagnostic references for diseases. Until recently, simultaneous quantification of cytokine profiles had not been possible. Now however, fluorescent microsphere immunoassays (FMIA) are able to measure multiple cytokines in a single sample. The following pro-inflammatory and anti inflammatory cytokines were quantified in equine plasma and serum samples: Interleukin (IL)-2, IL-4, IL-6, IL-10, Interferon (IFN)-γ, Tumor necrosis factor (TNF)-α.. AB - Cytokines are cell signalling proteins that mediate a number of different physiological responses. They are also biomarkers ...
The poly(orthoester) (POE)-poly(D,L-lactide-co-glycolide) (50:50) (PLGA) double-walled microspheres with 50% POE in weight were loaded with hydrophilic bovine serum albumin (BSA) and hydrophobic cyclosporin A (CyA). Most of the BSA and CyA was entrapped within the shell and core, respectively, because of the difference in their hydrophilicity. The morphologies and release mechanisms of proteins-loaded double-walled POE/PLGA microspheres were investigated. Scanning electron microscope studies revealed that the CyA-BSA-loaded double-walled POE/PLGA microspheres yielded a more porous surface and PLGA shell than those without BSA. The neat POE and PLGA yielded slow and incomplete CyA and BSA release. In contrast, nearly complete BSA and more than 95% CyA were released in a sustained manner from the double-walled POE/PLGA microspheres. Both the BSA- and CyA-BSA-loaded POE/PLGA microspheres yielded a sustained BSA release over 5 days. The CyA release pattern of the CyA-loaded double-walled POE/PLGA ...
Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals embedded in a polymeric microsphere; a kit prepared from the fluorescent microspheres; and a method of producing the fluorescent microspheres comprising swelling the polymeric microsphere so that into its pores can enter fluorescent nanocrystals, and then unswelling the polymeric micropsheres so that the fluorescent nanocrystals become physically entrapped in the pores of the unswelled polymeric microsphere. Also provided is a method of using the fluorescent microspheres comprising affinity ligand for determining the presence or absence of a predetermined number of analytes in a sample by contacting the sample with the fluorescent microspheres, and detecting the fluorescence signal pattern of excited fluorescent microspheres bound to one or more analytes of the predetermined number of analytes, if present in the sample.
The in vitro controlled release kinetics of human immunoglobulin G (IgG) of different loadings from microspheres of the biodegradable polymers poly(L-lactide) (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) were investigated. The microspheres were prepared by a double-emulsion technique. The release profiles exhibited an initial burst followed by a period of slow release, with PLA microspheres showing a faster rate of release than PLGA microspheres. The release rate increased with an increase in drug loading. Scanning electron microscopy (SEM) observations revealed wide differences in the morphology of microspheres made from different polymers. Drug loading had no significant effect on the morphology of the microspheres. Laser scanning confocal micrographs demonstrated a homogeneous drug distribution within the microspheres. Results from SEM and mass loss studies revealed no significant extent of polymer erosion after 50 days of release. Modeling studies within the first 50 days of incubation ...
Hollow glass microspheres made from a low heat conductivity glass composition containing a high vacuum and a thin metal coating deposited on the inner wall surface of the microspheres are described. The hollow glass microspheres are used to make superior insulation materials in the construction of highly efficient solar energy collectors. The hollow glass microspheres are made by forming a liquid film of molten glass across a coaxial blowing nozzle, applying a metal vapor blowing gas at a positive pressure on the inner surface of the glass film to blow the film and form an elongated cylinder shaped liquid film of molten glass. A transverse jet is used to direct an inert entraining fluid over and around the blowing nozzle at an angle to the axis of the blowing nozzle. The entraining fluid as it passes over and around the blowing nozzle fluid dynamically induces a pulsating or fluctuating pressure field at the opposite or lee side of the blowing nozzle in the wake or shadow of the coaxial blowing nozzle.
Fluoresbrite® carboxylate microspheres are fluorescent monodispersed polystyrene microspheres that have carboxylate groups on their surfaces which can be activated for the covalent coupling of proteins. Polysciences Fluoresbrite® particl
D=Drug, EU=Eudragit, M=Methocel. Assay methods of prepared microspheres:. Approximately 20 mg equivalent amount of Glibenclamide Microspheres was taken in a 100 ml volumetric flask and dissolved with minimum quantity of methanol. Few ml of phosphate buffer pH 7.4 was added and sonicated for 15 minutes in a sonicator to make a clear solution and made it 100 ml with phosphate buffer. Then the solution was finally filtered. Approximately 10 ml of the above solution was taken (if further dilution is necessary) in another volumetric flask and made it 100 ml with phosphate buffer. Absorbance value was determined using UV spectrophotometer at a wavelength of 242 nm. Using the absorbance value, the amount of drug entrapped was determined with the help of standard curve. Percent drug loading and drug entrapment efficiency was calculated by using the following equation. % drug Loading = (Actual drug loading / Weighed quantity of microspheres) X 100. Drug entrapment efficiency (%) = (Actual drug loading / ...
DNA vaccines or proteins are capable of inducing specific immunity; however, the translation to the clinic has generally been problematic, primarily due to the reduced magnitude of immune response and poor pharmacokinetics. Herein we demonstrate a composite microsphere formulation, composed of mesoporous silica spheres (MPS) and poly(d,l-lactide-co-glycolide) (PLGA), enables the controlled delivery of a prime-boost vaccine via the encapsulation of plasmid DNA (pDNA) and protein in different compartments. Method with modified dual-concentric-feeding needles attached to a 40 kHz ultrasonic atomizer was studied. These needles focus the flow of two different solutions, which passed through the ultrasonic atomizer. The process synthesis parameters, which are important to the scale-up of composite microspheres, were also studied. These parameters include polymer concentration, feed flowrate, and volumetric ratio of polymer and pDNA-PEI/MPS-BSA. This fabrication technique produced composite ...
The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a pre-determined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.
TY - JOUR. T1 - The organ targetability of small and large albumin microspheres containing free and HSA conjugated methotrexate. AU - Kim, Chong Kook. AU - Hwang, Sung Joo. AU - Lee, Myung Gull. PY - 1993/1/15. Y1 - 1993/1/15. N2 - The organ-targeting ability of [3H]methotrexate ([3H]MTX), [3H]MTX-human serum albumin (HSA) conjugates, and small (mean volume diameter, 10.0 μm) and large (mean volume diameter, 22.4 μm) size hydrophilic albumin microspheres (HAMs) containing different ratios of [3H]MTX-HSA conjugates to [3H]MTX was evaluated after i.v. administration of the compounds, equivalent to 150 nCi via the tail vein of mice. The total radioactivity in the lung increased immediately in a few minutes after i.v. injection of the both small and large HAMs, and then declined for up to 3-4 weeks, apparently reaching a plateau thereafter. However, the radioactivity in the liver, spleen and kidney increased slowly during the rapid decrease in radioactivity in the lung. This suggested that the ...
Page contains details about nitrogen-doped nanofibrous microsphere-based supercapacitor . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Objectives: The efficacy of rifampicin-loaded polymeric microspheres (RPLGA) delivered to guinea pigs infected with Mycobacterium tuberculosis (H37Rv) was compared with a daily dose of nebulized rifampicin suspension. Methods: Aerosol-infected animals were subjected to multiple dose or single dose treatment with RPLGA, PLGA microspheres or micronized rifampicin suspension
Magneticaly-responsive microspheres having Protein A associated with the outer surfaces thereof are reacted with antibodies selective to the cells, bacteria, or viruses to be separated from a mixed population to attach the antibodies in oriented relation with their Fab arms extending outwardly, and the microspheres are then used in a magnetic separation procedure. The preferred microspheres are prepared from a mixture of albumin, Protein A, and magnetic particles, the microspheres being prepared so that the Protein A is present in the exterior surfaces for antibody binding.
Novel magnetic-antimicrobial-fluorescent multifunctional hybrid microspheres with well-defined nanostructure were synthesized by the aid of a poly(glycidyl methacrylate) (PGMA) template. The hybrid microspheres were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), X-ray diffraction (XRD) and digital fluorescence microscope. The as-synthesized microspheres PGMA, amino-modified PGMA (NH2-PGMA) and magnetic PGMA (M-PGMA) have a spherical shape with a smooth surface and fine monodispersity. M-PGMA microspheres are super-paramagnetic, and their saturated magnetic field is 4.608 emu·g−1, which made M-PGMA efficiently separable from aqueous solution by an external magnetic field. After poly(haxemethylene guanidine hydrochloride) (PHGH) functionalization, the resultant microspheres exhibit excellent antibacterial performance against both Gram-positive and Gram-negative bacteria. The fluorescence feature originating from the
Functional magnetic particles are formed by dissolving a mucopolysaccharide such as chitosan in acidified aqueous solution containing a mixture of ferrous chloride and ferric chloride. As the pH of the solution is raised magnetite is formed in situ in the solution by raising the pH. The dissolved chitosan is a polyelectrolyte and forms micelles surrounding the granules at pH of 8-9. The chitosan precipitates on the granules to form microspheres containing the magnetic granules. On addition of the microspheres to waste aqueous streams containing dissolved ions, the hydroxyl and amine functionality of the chitosan forms chelates binding heavy metal cations such as lead, copper, and mercury and the chelates in turn bind anions such as nitrate, fluoride, phosphate and borate.
The process of creating these beads is quite simple, according to Sathe. The surface of the beads contains a long-chain carbon molecule that makes the beads hydrophobic, meaning they repel water. The beads are dissolved in butanol and washed several times. Then the beads are counted and optical and magnetic nanocrystals are added to the suspension either simultaneously or sequentially. After 15-20 minutes, the butanol is removed to get rid of any remaining nanoparticles that didnt get incorporated into the beads and the beads are washed with ethanol. Then the beads are coated with a polymer that creates a hydrophilic surface on the beads. This allows the beads to be functionalized by adding antibodies or DNA molecules to the surface that will capture the target molecules.. These beads are dual-function -- both optical and magnetic -- but according to Sathe, more functions can be added to the beads. "Adding them is as easy as adding the nanoparticles into the solution. You just have to make sure ...
The treatment of PVT-WGA SPA beads with positively charged polyethyleneimine (PEI) blocks potential non-specific binding sites on the SPA bead surface. There are two SPA bead types available with PEI treatment. The PVT-WGA-PEI type A SPA beads are treated with PEI prior to the coupling of WGA to the PVT SPA bead. The PVT-WGA PEI type B SPA beads are treated with PEI after the WGA coupling stage. The PVT-WGA-PEI type A and type B SPA beads exhibit different characteristics with regard to the non-specific binding of radiolabelled ligand directly to the SPA bead. Therefore, both bead types should be evaluated when deciding which SPA bead to use and both are included in the Select-a-Bead Kit. The binding capacity of both bead types for cell membrane protein remains 10-30 μg membrane protein per milligram of SPA bead.. SPA Scintillation beads are microspheres containing scintillant which emit light in the blue region of the visible spectrum. As a result, these beads are ideally suited to use with ...
PFH, which is a liquid at ambient temperature, is non-toxic and has been used in the preparation of multifunctional microspheres for medical and pharmaceutical applications (Giesecke & Hynynen 2003). The mechanism for the preparation of hollow microspheres takes advantage of its properties of immiscibility and volatility (Pisani et al. 2006). PFH and PMSQ were injected with appropriate flow rates under an applied voltage, in which the electrical forces acted on the driving liquid and led to the establishment of the cone. The PMSQ solution was accelerated by the electrical field, while the flow of PFH was dominated by viscous stresses. Hence, the electrical forces acting on the PMSQ film drive the inner viscous liquid so that both liquids flow steadily with the same velocity. Thus, concentric droplets can be obtained with PMSQ around the PFH; these are stable and retain their integrity owing to their immiscibility. The core material (PFH) can change phase from liquid to gas at ambient temperature ...
EPS puffed beads are created by applying steam to EPS resin in an enclosed chamber. The Pentane gas in each piece of resin expands from the heat causing the beads to grow by 30 to 35 times their original size. When they are fully puffed the beads are primarily made up of air. The puffed beads are then transferred to a drying chamber where they are subjected to dry air and from there into large poly bags for shipping. For very large applications the puffed beads can be blown directly into a 53 trailer.. Another major application for puffed EPS beads today is in the manufacture of bean bag chairs and poufs. Bean bag chairs, popular in the 60s, have seen resurgence in popularity in the past several years. The puffed EPS beads are sold to manufacturers in truckload quantities and blown or poured into the shells using specialized equipment.. ...
Practical design of composite materials suggests a need for an improved quantitative understanding of the interaction between acoustic waves and microspheres. In this work, we first investigate the Mie resonance of a single spherical microsphere embedded in polymer by referring to the elements of the scattering matrices. It shows that a hollow glass microsphere presents a similar monopole resonance as an air microsphere, but the resonance of a hollow glass microsphere occurs at a higher frequency with a wider bandwidth than that of an air microsphere. Then, using the multiple scattering method, we show that the low-frequency gap of a periodic array of microspheres in polymer is mainly induced by the monopole resonance of the single microsphere, and find a wide band gap under very low concentrations of the microspheres. The viscosity of the components induces the energy dissipation under the resonant scattering, and the attenuation of ultrasonic longitudinal waves in the polymer slab is dominated ...
The pH-responsive core-shell microspheres of poly(styrene-co-methylacrylic acid) (PS-co-PMAA) containing a polystyrene (PS) core and a poly(methylacrylic acid) (PMAA) shell are synthesized by one-stage soap-free copolymerization and the catalyst system palladium-iminodiacetic acid (IDA-Pd) is immobilized on the outer shell-layer of the core-shell microspheres to form the quasi-homogeneous and easily accessible catalyst PS-co-PMAA-IDA-Pd. This quasi-homogeneous PS-co-PMAA-IDA-Pd catalyst is highly dispersed in the reaction medium just like a homogeneous one and can be separated like a heterogeneous catalyst by adjusting the pH of the reaction medium. Suzuki reactions employing the quasi-homogeneous PS-co-PMAA-IDA-Pd catalyst are efficiently performed in water as the sole solvent under mild conditions such as room temperature. The PS-co-PMAA-IDA-Pd catalyst is also used in Heck reactions of a wide range of aryl halides with styrene and proves to be efficient in aqueous solution. The ...
0008] In yet another aspect, a device is provided for producing a low-noise RF signal based on regenerating light via optical nonlinearity in an optical whispering gallery mode resonator. This device includes a laser that produces laser light at an optical pump frequency; an optical whispering gallery mode resonator that supports whispering gallery modes and exhibits optical nonlinearity to cause nonlinear optical mixing by taking energy from the laser light at the optical pump frequency to generate light at one or more new optical frequencies different from the optical pump frequency, the optical whispering gallery mode resonator exhibiting an opto-electric effect; an electrode formed on the optical whispering gallery mode resonator to apply an RF signal containing an RF frequency and one or more RF harmonics of the RF frequency to the optical whispering gallery mode resonator to cause optical modulation of light inside the optical whispering gallery mode resonator via the opto-electric effect; ...
Longo W.E.; Iwata H.; Lindheimer T.A.; Goldberg E.P., 1982: Preparation of hydrophilic albumin microspheres using polymeric dispersing agents
... (Magnetic Microspheres). 2.5µm magnetic carboxylated fluorescent beads with emission at 450nm and excitation below 435nm, 1ml.
Dev, V., Zeng, H., Forrester, J. S., Eigler, N., Tian, Y. Q., Hickey, A. J., ... Litvack, F. (1994). Microspheres for Drug-Delivery to the Arterial-Wall - A Study of Kinetics, Toxicity and Effects of Corticosteroid Loaded Microspheres. In pp. A19-A19. .. ...
A total of 47 Sprague-Dawley rats (25-35 days old) of either sex were used. Animals were subdivided into the following six groups. In group 1 (n = 6) or control, no injections were performed on the gastric walls. In group 2(n = 8), tetramethylrhodamine isothiocyanate (TRITC)-filled latex microspheres were injected into the wall of the gastric fundus. In group 3 (n = 10), TRITC-filled latex microspheres were injected into the wall of the gastric corpus. In group 4 (n = 8), TRITC-filled latex microspheres were injected into the wall of the antral/pyloric area (see below). In group 5(n = 10), double immunocytochemistry (TH and NOS) was carried out, and no injections were performed on the gastric walls. Ingroup 6 (n= 5), esophageal distension followed by double immunocytochemistry (TH and c-Fos) took place, and no injections were performed on the gastric walls. Unless otherwise specified, all rats were injected with fluorogold (Fluorochrome, Englewood, CO; 20 μg/1 ml saline/rat, ip) to label vagal ...
Hierarchical N-doped TiO2 microspheres with exposed (001) facets [N-TiO2-(001)] were synthesized through a simple, fluorine-free solvothermal reaction with subsequent thermal treatment. The results show that the hierarchical N-TiO2-(001) microspheres are made up of numerous TiO2 nanosheets, and that isopropylamine (IPAN) acts as both the nitrogen source and the capping and shape-controlling agent that generates the high-energy (001) facets. In addition, IPAN is also effective in increasing the onset temperature of the phase transformation of TiO2 from anatase to rutile. Compared with the commercially available P25 TiO2, the as-prepared TiO2 microspheres exhibit good photocatalytic activity and high stability under visible-light irradiation. The high photocatalytic performance is derived from the synergy effect of N-doping and the separation of photogenerated electrons and holes among different facets, as evidenced by surface photovoltage spectroscopy. ...
Silver Coated Glass Microspheres work well for increasing the conductivity of bond lines, but they lack the capability to deform when compressed to give increased conductive contact between the surfaces of the bond line. These newly released Silver Coated PMMA Microspheres offer the low weight deformable pmma cores, and 250nm thick silver coating for high conductivity.. Conductivity of this product has been measured at ,0.5ohm per square with a 30% by volume preparation. Sizes available cover both the common 50 micron (45-53um) and 100 micron (90-106um) sizes and many others.. These spheres are perfect for producing anisotropic (only conductive in one direction) conductive bond lines.. Actual bond line thickness achieved will be a function of the assembly pressure and the size spheres selected.. In addition to being high conductive these silver coated PMMA is bio-compatible.. ...
What a creative alternative to power-hungry digital displays. This large outdoor billboard is totally environmentally friendly because compared to LCD and LED displays that run on electricity, this display takes no energy to run. This creative outdoor billboard is made with reflective tape, visible only when illuminated by headlights in the darkness, created by ad agency Cossette. To promote a local 24-hour McDonalds in Canada, Cossette Vancouver designed this reflective billboard thats only visible at night when cars pass by. By day, the billboard appears blank with no message, but at night, motorists driving along the highway reveal Mickey-Ds clever advertisement with their car headlights. Not only does this display save energy, it can be put anywhere, even in cities with strict requirements on flashing and lit displays.. Even though this particular display was made using reflective tape, many types of retroreflective media can be made by incorporating retroreflective microspheres in a ...
With over 35 years experience, Estapor® Microspheres is a leading brand of polymeric supports for in vitro diagnostics, life sciences, biotechnology, cosmetics, electronics and environment applications.
With over 35 years experience, Estapor® Microspheres is a leading brand of polymeric supports for in vitro diagnostics, life sciences, biotechnology, cosmetics, electronics and environment applications.
Lookup HS Codes for Thailand xiii 70.18.20 Glass microspheres not exceeding 1 mm in diameter. Avalara LandedCosts helps determine your duty rates and other import taxes for Thailand.
... The global market for microspheres reached nearly $2.3 billion in 2014. This market is - Market research report and industry analysis - 9307163
Anal beads are available in many sizes, with individual beads measuring from 25 mm in diameter to 125 mm diameter or larger. Most users enjoy beads of approximately 45 mm, but most will become more adventurous with experience, and try larger sizes. Anal beads are commonly made of silicone, plastic, rubber, latex, glass or metal and end with a ring or similar handle designed for pulling. The purpose of this ring is to prevent the beads from becoming fully lodged in the rectum, and to ease removal. The beads may either be joined flexibly, requiring individual insertion, or by a semi-rigid thin shaft, allowing anal insertion in a single motion. Both arrangements are forms of the sexual art of "beading off". The many nerve endings of the sphincter provide arousal both during insertion and removal, and larger beads may create feelings of pressure while in the rectum. Some anal beads are enhanced with vibration technology to enhance pleasure. ...
1Laboratory of Cancer Drug Therapeutics and Mammalian Cell Technology, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel; 2Molecular Mechanisms of Angiogenesis, Universite de Bordeaux I, Talence, France; 3Department of Neurological Sciences, University of Milan, Milan, Italy; and 4Laboratory of Neurosurgical Oncology, Brigham and Womens Hospital, Harvard Medical School, Boston, ...
The present invention relates to the use of hollow microspheres filled with a hydrocarbon, to introduce uniform cell geometries in syntactic foams having a bimodal cell structure. The rigid foam product includes from 20 to 80 percent by weight of the hollow microspheres, the microspheres having average diameters ranging from 80 to 200 microns. The microspheres are encapsulated from 80 to 20 percent by weight of a closed cell polyurethane foam, the cells of the foam having average diameters from 0.01 to 60 microns.
LumAvidin Microspheres are avidin-coupled polystyrene microparticles that have been color coded into 100 spectrally distinct sets, or
Closeout Item - Last Chance. From a country rich in tradition and history, Chinese Lampwork Glass Beads are now in stock. We are very proud to bring to market an affordable selection of contemporary dot and eye lampwork beads. For the production designer and fashion houses, these beads are the perfect accent filler to your beading creations. These beads are all handmade so size and colors vary as you would expect with any handmade art form. Sizes range from 4mm to 19mm.. ...
An Electrochemical DNA Microbiosensor Based on Succinimide-Modified Acrylic Microspheres. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
xMAP® Technology combines advanced fluidics, optics, and digital signal processing with proprietary microsphere technology to deliver multiplexed assay capabilities. Featuring a flexible, open-architecture design, xMAP Technology can be configured to perform a wide variety of protein or nucleic acid assays quickly, cost-effectively and accurately. xMAP technology enables multiplexing of biological tests (assays), reducing time, labor, and costs over traditional methods such as ELISA, western blotting, PCR, and traditional arrays. Systems using xMAP Technology perform discrete assays on the surface of color coded beads known as microspheres, which are then read in a compact analyzer. Using multiple lasers or LEDs and high-speed digital-signal processors, the analyzer reads multiplex assay results by reporting the reactions occurring on each individual microsphere.. About ...
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Availability of DNA sequence data on numerous organisms has revolutionized the way biological queries are addressed today. Focus of activity has largely shifted from discovery to application. Things that were considered far-fetched only a few years ago seem to be within our reach, such as personalized medicines. New informatics and research tools have been devised to handle and analyze the influx of huge amount of data such as gene chips and microarrays or newly introduced nanoarrays. These devices are used to monitor biochemical and molecular interactions in a highly parallel and automated fashion. Such applications are also multiplexed on microspheres for diagnostics purposes. Due to the advantages of high throughput and high sensitivity, arrays and microspheres are fast becoming indispensable tools in diagnostics, drug discovery, toxicology, clinical trials and other disciplines. Of all the components needed to make sensitive and robust devices, surface chemistry is of the key importance since it not
In search of an injectable cellular delivery vehicle for tissue regeneration, porous microspheres fabricated from the synthetic polypeptide of poly(γ-benzyl-l-glutamate) (PBLG) were developed. The structural and morphological characteristics of the microspheres could be adjusted by changing the amounts of th
Near infrared (NIR) emitting materials represent powerful tools for biosensing and light sources for bioimaging due to the high transparency of biological organisms in this spectral window.1 Therein, NIR luminescent colloidal probes with sharp emission lines are often utilized. Recently, polymer whispering gallery mode (WGM) microresonators with narrow luminescence and laser emission have been reported.2 Furthermore, π-conjugated organic and polymer microparticles, in some cases doped with rare-earth metals, were shown to exhibit resonant emission and lasing in the visible and NIR region.2,3 Such organic microresonators find applications for barcoding in live cells, where lasing with a unique spectral profile makes it possible to distinguish each cell.4 However, NIR emitters often suffer from low luminescence efficiency because of the small energy gap between the highest-occupied and lowest-unoccupied molecular orbitals (HOMO and LUMO, respectively), which causes non-radiative thermal ...
A composition for saturation of preformed, previously cured foam substrates having an at least partially open cell configuration, includes a polymer binder in which microspheres containing a phase change material are dispersed. Preferred phase change materials include paraffinic hydrocarbons. The microspheres may be microencapsulated. A preferred cured foam substrate is a skived polyurethane or polyether foam of from 20 to 1000 mils in thickness, preferably 20 to 200 mils in thickness, having up to 6 ounces per square yard or more of encapsulated phase change material embedded in a polymer binder. One method of applying the binder with dispersed encapsulated phase change materials is by applying a binder/microsphere dispersion to the upper surface of a previously cured foam sheet with, then drawing a vacuum from the underside of the cured foam sheet to permeate from 20% to 100% of the cured foam sheet with the binder/microsphere dispersion. The resulting product is then cured. An alternative method of
Shivarov et al. designed and validated this BNA[NC] probe bead-based assay for the Luminex Lab Scan 200 flow platform to allow for the detection and quantification of somatic mutations in Leukemia! -.- How does the assay work? Primers are designed to allow for the amplification of a DNA sequence fragment that contains the mutated sequence…
Embosphere Microspheres are the most clinically studied round embolic and provide predictable, proven results for embolisation treatment.
In order to minimize the side effects of chemotherapy concurrently with the enhancement of its therapeutic action is to use it on devices that enable a controlled drug release, by vectors, such as polymeric microspheres, which act as a drug carrier, modifying its distribution pattern in the organism. Paclitaxel ((Taxol®) is a drug used primarily in the treatment of ovarian, breast, lung and bladder cancer. Due to its antimitotic and antiproliferative action, there is a potential interest in cancer therapy. However, the success of this clinical application is limited to low solubility in water and toxic action. The objective of this study was to obtain and characterize physic-chemically the bioresorbable and biocompatible copolymer poly (L-co-D, L lactic acid) (PLDLA) microspheres encapsulating the paclitaxel chemotherapy. The simple emulsion technique allowed to obtain spherical microspheres, verified by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The average size of ...
Mastering the complexity of PLGA microsphere manufacturing by Daniel Leblanc, Senior Vice President of CMC Operations, Flexion Therapeutics, Inc.
In recent years, many temperature sensing devices based on microsphere resonators have emerged, attracting an increasing research interest. For the purpose of this review article, microsphere resonators are divided according to their constituting materials, namely silicone, silica, compound glass, and liquid droplet. Temperature monitoring relies mainly on the thermo-optic/thermal expansion of the microspheres and on the fluorescence of the doped ions. This article presents a comprehensive review of the current state of the art of microsphere based temperature sensing and gives an indication of future directions.