Detection of diseases in an early stage is very important since it can make the treatment of patients easier, safer and more ecient. For the detection of rheumatic diseases, and even prediction of tendencies towards such diseases, capillaroscopy is becoming an increasingly recognized method. Nail-fold capillaroscopy is a non-invasive imaging technique that is used for analysis of microcirculation abnormalities that may lead todisease like systematic sclerosis, Reynauds phenomenon and others.. The main goal of this master thesis project is to provide new tools and techniques for the analysis of capillaroscopy images from the nail-fold area. Image processing and machine learning techniques are applied to images obtained by digital microscopes, like Mediscope as produced by Optilia Instruments AB, Sollentuna. This thesis oers a novel way for segmentation of capillaries from images as well as (semi)automatic capillary width calculation and automatic annotation of capillaries. These tools provide new ...

Objective Investigation of the reliability of the qualitative and semiquantitative scoring of nailfold videocapillaroscopy (NVC) assessment between two raters in a systemic sclerosis (SSc) cohort.. Methods Two raters from different centres blindly assessed the NVC images of 71 consecutive patients with SSc qualitatively as belonging to the scleroderma spectrum (SDS) category (early, active, late scleroderma pattern or scleroderma-like pattern) or to the normal category and semiquantitatively by calculating the mean score for capillary loss, giant capillaries, microhaemorrhages and capillary ramifications. Inter-rater/intrarater agreement was assessed by calculation of the proportion of agreement and by κ coefficients. Rater agreement of mean score values of hallmark parameters was assessed by intraclass correlation coefficients.. Results The inter-rater/intrarater proportion of agreement to qualitatively assess an image as belonging to the SDS category or not was 90% and 96%, whereas ...

NAILFOLD VIDEOCAPILLAROSCOPY AND OTHER PREDICTIVE FACTORS ASSOCIATED WITH NEW DIGITAL ULCERS IN SYSTEMIC SCLEROSIS: DATA FROM THE CAP STUDY ...

Results Seven-teen SSc patients were found lSSc (17/31, 54.83%; mean disease duration 8.70 yrs) the remaining four-teen were found dSSc (14/31, 45.1% mean disease duration 11.14 yrs). The predominant DC TA patterns observed were spot (violet and suffused pink sometimes associated to punctiform vessels) on the hands and reticular (alveolar and branched vessels) on the other sites (mainly face). Spot DC TA pattern (prevalent in the hands) was found mainly associated with early/active NVC patterns in lSSc patients (91% vs. 9% early/active vs late NVC pattern, respectively), whereas reticular DC TA pattern was found mainly associated with active/late NVC patterns in dSSc patients, (92% vs 8% active/late vs early NVC pattern, respectively). In addition, TA on the palms appeared as spot DC pattern in 15 of 31 patients, including 13in the ACA positive patients (13/20; ROC area 0.7, p=0.03). A DC TA pattern consisting of suffused pink was observed on the palms of 13 ...

NASCIF, Ana K. S. et al. Inflammatory myopathies in childhood: correlation between nailfold capillaroscopy findings and clinical and laboratory data. J. Pediatr. (Rio J.) [online]. 2006, vol.82, n.1, pp.40-45. ISSN 0021-7557. http://dx.doi.org/10.2223/JPED.1435.. OBJECTIVE: Nailfold capillaroscopy is an important tool for the diagnosis and follow-up of patients with rheumatic diseases, in particular dermatomyositis and scleroderma. A relationship has been observed in adults between improved capillaroscopic findings and reduced disease activity. Our aim was to correlate disease activity (clinical and laboratory data) and nailfold capillaroscopy findings in 18 patients with inflammatory myopathies. METHODS: This prospective study included 13 juvenile dermatomyositis patients (Bohan and Peter criteria) (mean age of 8.8 years) and five patients with overlap syndrome (mean age of 15.7 years). We evaluated disease activity (skin abnormalities and muscle weakness, muscle enzymes and acute phase ...

Dermoscopy (DC) is a noninvasive technique used in the early diagnosis of melanoma5 and nonmelanoma skin cancers, as well as inflammatory skin disorders (psoriasis, lichen planus, seborrheic dermatitis)6. The vascular structures of these conditions are detectable by DC, which has also provided data similar to NVC images commonly used in the study of nailfold capillaries in connective tissue diseases7.. In our study, DC was used to better appreciate vascular features of TA on selected anatomic sites (e.g., face, chest, hands, forearms) and to provide a morphological description of altered skin microcirculation in patients with SSc from a novel perspective. Using this approach, capillaries perpendicular to the skin, as well as the deeper portions of cutaneous microcirculation, usually not visible, become visible as they appear similar to TA.. DC patterns were investigated from 31 women with SSc (median age 55 yrs, median disease duration 8 yrs) showing skin TA and grouped into limited (lSSc) and ...

Capillaroscopy is a method used to examine a patients microcirculation and assess pathological changes. It is completely safe and noninvasive. Using some sort of microscopy, the clinician looks through the epidermis of the nailfold to view the capillaries of the distal papillae.3. Ariane Herrick, MD, is professor of rheumatology at the University of Manchester and honorary consultant rheumatologist at Salford Royal NHS Foundation Trust, England. She explains that nailfold anatomy makes it an ideal place to evaluate the microcirculation. In most of the skin, capillaries run perpendicular to the skin surface, and only the tip of the loop is visible.. Dr. Herrick explains, At the nailfold, capillaries run parallel, rather than perpendicular, to the skin surface, and they can, therefore, be visualized noninvasively when magnified. Capillaries themselves are invisible, but what can be seen is the column of red blood cells within the capillaries.. This is of interest to rheumatologists in ...

We sought to assess whether nailfold videocapillaroscopy (NVC) patterns are associated with levels of angiogenic factors in systemic sclerosis (SSc). Circulating endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) were measured in the peripheral blood of 60 consecutive SSc patients. Serum levels of eight endothelial markers were measured first in these 60 patients, and then in an independent replication cohort of 43 SSc patients in case of association with NVC patterns. NVC patterns were determined by four independent investigators blinded to vascular markers. Patients with the late-NVC pattern exhibited lower EPC levels (P | 0.0001) and higher VEGF levels (P = 0.03). Higher VEGF levels were confirmed to be associated with the late-NVC pattern in the replication cohort (P = 0.01). By multivariate analysis focused on biomarkers, lower EPC (P = 0.03) and higher VEGF levels (P = 0.001) were independently associated with the late-NVC pattern. In an alternate multivariate model

Place of OriginAnhui, China (Mainland) Brand NameJNR color nailfold microcirculation microscope Model NumberXW880 TheoryBiological Microscope DrawtubeOther Specifications 1.microcirculation diagnosis ...

Place of OriginTaiwan Brand NameDigiLens Model NumberDigiLens DMX960 II TheoryVideo Microscope DrawtubeTrinocular Microcirculation microscope: DigiLensDMX960 II Portable Color LCD Mi...

Although an early capillaroscopic pattern can occur in patients who have suffered from Raynauds phenomenon for many years, the term early is used because this pattern tends to occur initially; it also can be observed in patients with shorter disease duration than in those with active or late patterns. However, it must be recognized that capillaroscopic patterns are descriptive and that there is inevitable overlap between patterns. The differences between the pattern in SSc and the normal pattern of healthy subjects or patients with benign primary Raynauds phenomenon can be readily observed (see Figure 12).. The development of robust scoring systems to quantify the microvascular change is essential to the performance longitudinal studies. For this reason, a practical system to score these capillaroscopic alterations in patients with SSc has been recently proposed and validated.7,8 Interestingly, in studies on clinical findings over time, about 15%-20% of primary Raynauds phenomenon are ...

TY - JOUR. T1 - Uniphasic Blanching of the Fingers, Abnormal Capillaroscopy in Nonsymptomatic Digits, and Autoantibodies. T2 - Expanding Options to Increase the Level of Suspicion of Connective Tissue Diseases beyond the Classification of Raynauds Phenomenon. AU - Ingegnoli, Francesca. AU - Gualtierotti, Roberta. AU - Orenti, Annalisa. AU - Schioppo, Tommaso. AU - Marfia, Giovanni. AU - Campanella, Rolando. AU - Mastaglio, Claudio. AU - Meroni, Pier Luigi. AU - Boracchi, Patrizia. PY - 2015. Y1 - 2015. N2 - In patients with Raynauds phenomenon (RP), the role of medical history, capillaroscopy, and autoantibodies in order to provide an early diagnosis of connective tissue disease (CTD) were examined. 115 consecutive adults with uni-, bi-, or triphasic colour changes of the fingers were studied. RP was bilateral in 92.7% of patients. The middle finger was significantly more affected. A lack of association between fingers affected by RP and fingers with capillary abnormalities was observed OR = ...

This study confirms that the identification of distinct NVC patterns may be useful to evaluate the severity and the stage of the SS microvascular damage. The presence of the Scl70 antibodies seems related to a more rapid progression of the SS microangiopathy. On the contrary, the presence of the ACA …

The aim of this study was to assess nailfold capillaroscopic (NC) findings in patients with primary Sjögrens syndrome (PSS) with and without Raynauds phenomenon (RP) as well as in the presence of positive anti-SSA/Ro and anti-SSB/La antibodies. Videocapillaroscopy was performed in 150 patients with PSS. Data collected included demographics, presence of RP, PSS symptoms, antinuclear antibodies, rheumatoid factor, anti-Ro, anti-La, anti-CCP, salivary scintigraphy, labial biopsy, and NC findings. RP was present in 32% of PSS, keratoconjunctivitis sicca in 91%, oral xerosis in 93%, and skin or genital xerosis in 53 ...

The CAP study is a multicenter, observational, clinical study in patients with systemic sclerosis. The study aims at determining the usefulness of nailfold videocapillaroscopy and patient-specific disease-related factors in predicting the occurrence of digital ulcers within a 6-month observation period. Patients with cutaneous forms of systemic sclerosis (limited or diffuse), with or without history of digital ulceration are eligible. The study will enroll 500 patients at 70 centers ...

The sparing effect of hemiplegia in rheumatic diseases has been described, but reports on systemic sclerosis (SSc)-spectrum disorders are unusual. SSc-spectrum disorders are complex diseases of unknown origin characterized by multisystem involvement,

International Journal of Rheumatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on paediatric and adult rheumatological and musculoskeletal conditions, including topics such as basic research, therapy, surgery, and imaging.

Systemic sclerosis is an autoimmune disease characterised by microvascular involvement and fibrosis affecting the skin, lung, and heart. To date, our understanding of the changes in MICs, T cells, and cytokines in SSc is still incomplete. In our study, we hypothesised that SSc is associated with alterations in MICs, T cell subsets (CD4/CD8), and cytokine production in the lung, blood, and skin. We also hypothesised that these alterations contribute to the genesis of the pulmonary and skin lesions and would therefore correlate with the clinicopathological characteristics of these lesions. We carried out this investigation to fill this existing gap in the literature and to test our hypotheses. Therefore, we examined 19 patients with SSc and six matched healthy individuals. Our results clearly showed the following: (1) SSc has a predilection for middle aged women; (2) MICs and cytokine concentrations (IL-1β and TNFα) are increased in the BALF, blood, and skin lesions of patients with SSc, (3) ...

Properties:Rehabilitation Therapy SuppliesPlace of Origin:Guangdong, China (Mainland)Brand Name:QianheModel Number:FT-007Type:hydro ionic foot detox spa, foot spa, body massage, farredProduct name:Single ion detox machin...

Background: A small number of studies used nailfold capillaroscopy (NC) in the evaluation of nailfold capillary changes in Behçets disease (BD). The purpose of this study was to investigate the characteristics and frequency of nailfold capillary changes in BD by dermatoscopy and videodermatoscopy and to develop a scoring system for those capillary changes to predict the activity and severity of the disease. Methods: We performed NC on 40 BD patients and 20 healthy controls with dermatoscopy and videodermatoscopy. Capillary morphology, distribution, and density were analyzed qualitatively and quantitatively. We also assessed the activity and severity of the disease with BD Current Activity Form and BD Severity Score Classification and evaluated the relation of these scores with morphology scores and capillary density. Results: Capillary morphologic alterations were encountered significantly more in BD group (P , 0.05). Loss of continuity in capillary loops and irregularity of capillary ...

Editor,-Studies on visual field and peripheral circulation had led to the hypothesis that the eye might be involved in the vasospastic syndrome,1 a potential contributor to glaucomatous optic neuropathy.2 In some patients with peripheral vasospasms, visual field defects worsened after cold provocation, and, often, both peripheral vasospasms and visual field defects improved after calcium channel blocker treatment.1Because these and newer observations3 suggest some parallels in ocular and digital blood flow regulation, the relation between ophthalmic artery and nailfold capillary blood flow velocities was evaluated.. Fifty patients with primary open angle glaucoma with a mean age of 67 (SD 15) years were examined. Excluded were patients with previous filtering surgery or systemic and cardiovascular diseases. Blood flow velocity in nailfold capillaries was assessed in one randomly chosen finger of the right hand (totally arbitrary choice) by means of nailfold capillaroscopy.4 The velocities ...

Type:Blood Analysis SystemBrand Name:JIAHUAModel Number:JH1004Place of Origin:Jiangsu, China (Mainland)Item:Nailfold video capillaroscopeMicroscope Magnification:420 times (C plus model)Built-in camera pixels:480,000 pix...

Raynauds phenomenon (RP) is a vasospastic disorder characterized by episodic color changes of blanching, cyanosis, and hyperemia in response to cold and/or emotional stress. Although most typically noted in the fingers, the circulation of the toes, ears, nose and tongue is also frequently affected. Population studies have shown that RP in adults is more common in women than men, with prevalence estimates ranging from 4% to 30%. Geographic variations in the prevalence reflect differences in climate. RP may be a primary or a secondary process. LeRoy and Medsger suggested criteria for primary RP: symmetric attacks, the absence of tissue necrosis, ulceration or gangrene, the absence of a secondary cause, negative antinuclear antibodies, normal nailfold capillaroscopy and a normal erythrocyte sedimentation rate. Secondary RP is characterized by an age of onset of more than 30 years, painful and asymmetric attacks, ischemic skin lesions, positive autoautoantibodies, capillaroscopic abnormalities ...

Type:Pathological Analysis EquipmentsBrand Name:JIAHUAPlace of Origin:Jiangsu, China (Mainland)Model Number:JH-950C CHANGSHAN950C L...

Six patients with juvenile DM received 50 mg/m2 of OP (day 1) and IVMP (day 2). Blood was drawn at baseline and at 5, 15, 30, 45, 60, and 90 minutes, and hourly (hours 2-8) after each dose. Samples were analyzed by reverse-phase high-performance liquid chromatography for levels of prednisolone and methylprednisolone. AUCs of OP and IVMP were determined by the trapezoid method; pharmacokinetic parameters were obtained using noncompartmental and compartmental analysis. ERLs were determined from freeze-frame video microscopy and nailfold capillaroscopy. ...

Type:Clinical Examination AidsBrand Name:ZHIHUIModel Number:880,990 Type Nailfold Capillary Microcirculation MicroscopePlace of Origin:Guangdong, China (Mainland)Size:90*80 cmMaterial:PlasticFunction:Nailfold capillary m...

Dear Editor,. Congratulations Canadian Family Physician and Dr Ran D. Goldman for the Child Health Update on Raynauds phenomenon (RP) [1]. I would like to point to a new study in childhood on this underrated functional vascular disease.. The pediatric research group of Gorski et al from Poland examined with the help of nail fold capillaroscopy and blood tests 66 patients with RG (34 undifferentiated RP and 32 secondary RP) aged 6-19 years and a control group with 20 healthy children [2]. Compared to the control group, significantly higher concentrations of endothelin-1 (p = 0.0134), sE-selectin and high-sensitivity C-reactive protein (hsCRP: p , 0.001) were found in the patients with RG, as well as a lower high-density lipoprotein cholesterol concentration in the lipid profile (p = 0.001). The group over 15 years also had higher levels of low-density lipoprotein fraction and triglyceride. As the analysis of multiple linear regression showed, among the capillaroscopic parameters, the more ...

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Constantine Daskalakis is the author of these articles in the Journal of Visualized Experiments: Non-invasive Assessment of Microvascular and Endothelial Function, A Reproducible Computerized Method for Quantitation of Capillary Density using Nailfold Capillaroscopy

Finally, we decide to exploit to the maximum the whole shape of the Madl by converting the head into a TV screen and do a character that would use the stance of the toy by making him having his hands in the pocket. But then we had to think to what to do with the TV screen...??? So we decided to make a tribute to the infamous Notorious BIG ...

In this study, 82 photomacrographs of nailfold capillary beds from 60 patients with scleroderma spectrum disorders (scleroderma, undifferentiated connective tissue disease, and dermatomyositis) and from 16 normal controls were analyzed blindly, using both semiquantitative and quantitative methods, t …

To the Editor:. We read with great interest the recent Images in Cardiovascular Medicine article by Girod et al1 regarding a case with tako-tsubo-like transient left ventricular dysfunction. In their article, the authors well described a case of this rather unusual disorder and also provided an impressive picture of a tako-tsubo (octopus catcher). Although the exact mechanism for this entity has yet to be clarified, there have been suggestions of abnormal microvascular involvement after emotional or physical stress in this still-mysterious transient disorder.2. This apparently extraordinary phenomenon has several similarities to the left ventricular dysfunction seen in cases of subarachnoid hemorrhage3 as well as brain death. This is of particular importance as some of these individuals become organ donors. Findings such as mild elevation of cardiac enzymes without evidence of obstructive epicardial arteries, reversible nature of the clinical course, and focal pathological changes in myocardium ...

Results. PBMC from patients with SSc produced significantly more APRIL (961 ± 151 pg/ml/105 cells) than control PBMC (798 ± 219 pg/ml/105 cells; p , 0.01). In patients with SSc, increased production of APRIL was associated with the presence of diffuse skin involvement, scleroderma lung disease, peripheral vasculopathy, greater capillary damage on capillaroscopy, and presence of anti-topoisomerase I (anti-topo I) antibodies. Multivariate regression analysis revealed anti-topo I antibodies as the only independent predictor of high production of APRIL by PBMC. ...

Sponsored by MAQUET Cardiopulmonary A.G.. COMPARISON OF MICROCIRCULATION DURING MECC AND COVENTIONAL ECC WITH COMPUTER CAPILLAROSCOPY IN AORTIC VALVE SURGERY: A COMPARATIVE MULTICENTER STUDY. Erich Gygax, T. Averina*, R. Muratov*, G. Shamsiev*, D. Khinchagov*, H. Jenni, B. Winkler, L. Bockeria*, T. Carrel. University Hospital Bern, Clinic for cardiovascular Surgery, Berne, Switzerland. Bakoulev Center Moskow*, Moskow, Russia. ...

We are located in the Institute of Immunity and Transplantation on the 2nd floor of the Royal Free Hospital. The institute is a state-of-the-art centre dedicated to research and clinical care for immune related disorders.. This location enables our patients to have blood tests and other specialised CTD related investigations (such as thermography and capillaroscopy) all at the time of their clinic appointment and under the one roof.. In addition our patients frequently undergo intravenous treatments such as pulsed methylprednisolone or intravenous immunoglobulin on PITU (planned investigation and treatment unit), adjacent to the institute.. ...

Background Many abnormalities are known to occur in the microcirculation in essential hypertension, including reduction in capillary density or rarefaction. Peripheral vasodilatation and angiogenesis are critical components of the physiological adaptation in normal pregnancy.Objective To investigate

Chronic venous congestion in spleen, depicted in the images below, may be identified by the presence of engorged vessels, some areas of hemorrhage may be found too.. [smooth=id:85;] Want a clearer concept, also. Read the articles on Chronic Venous Congestion. Compare it with normal histology of Spleen. See the images on Chronic Venous Congestion in Lungs. See the images on Chronic Venous Congestion in Liver ...

LDI Training Leading Edge Courses for Professionals A LDI Training Course Learn an integrated approach on how to analyze, design, install and test Production Safety Systems Using API RP 14C, API RP 14J,

ECE/TRANS/2016/14 - Road Map for the Accession to and Implementation of the European Agreement concerning the Work of Crews of Vehicles engaged in International Road Transport (AETR), of 1970 ...

Microcirculation accounts for about 99% of blood vessels in adults and mediates between the arterial and venous parts of the cardiovascular system, both structurally and functionally. Skin microcirculation consists of two vascular plexuses: superficial and deep. Microcirculation includes vessels...

ABSTRACT: In order to study the neonatal microcirculation, the capillary hemodynamics in skin was investigated in 43 full-term infants 2-7 days after birth. The nailfold capillaries of the thumb were visualized by means of television microscopy and the capillary blood cell velocity (CBV) was videophotometrically quantified in 107 microvessels. The skin temperature, mean arterial blood pressure, and heel puncture hematocrit were measured simultaneously to evaluate any relation with the CBV. The mean CBV in all infants was 0.38 ± 0.21 mm/s, with a range of 0.04 to 1.2 mm/s in individual capillaries. There was no correlation between CBV and skin temperature (27-33° C), mean arterial blood pressure (44-68 mm Hg), or postnatal age. However, a significant correlation was found between the log CBV and the skin prick hematocrit (r = −0.64, p | 0.001). It is concluded that the mean CBV during the 1st wk of life is not significantly different from the capillary velocity reported in adults. Normal variations

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ROP remains a significant cause of vision loss in the pediatric population. Although some risk factors have been identified, its development is complex and involves both environmental and genetic factors. This study aimed to initiate the identification of genes that may play a role in ROP susceptibility. Using the murine OIR model, we developed a mapping cross between C57BL/6ByJ and BALB/cByJ inbred mouse strains. These mice were confirmed to have significantly different vascular responses to OIR on P16, with the BALB/cByJ strain having smaller avascular areas than the C57BL/6ByJ strain. These results support those published by Dorrell, et al. [20], which found that while both strains have similar vaso-obliterative areas upon their return to normoxia on P12, the BALB/cByJ strain revascularizes more rapidly than the C57BL/6J strain. Genetically determined differences in retinal ocular morphology between the two strains may play a role in their responses to OIR. Recent reports using confocal ...

NVC - Dr. Bao and Spive, have consistently created intricately detailed customs. While theyve worked on several different toys, smaller (3 or

RP is classified into two categories: primary and secondary. Primary RP are vasospastic attacks precipitated by cold temperatures or emotional stress. Primary RP, which occurs in the absence of an identifiable disease, is most common in otherwise healthy females between 15 and 30 years of age. A family history of first-degree family members is reported in about 30% of cases. These attacks usually occur symmetrically and bilaterally in the hands. There is no underlying sign of tissue necrosis or gangrene (eg, digital pitting) and the underlying vasculature is normal. Nailfold capillary microscopy (see below) and physical examination findings are normal. If a patient meets criteria for primary RP and no new symptoms develop over 2 years of follow-up, the development of secondary disease is unlikely. The finding of abnormal nailfold capillaries on microscopy or specific autoantibodies are strong predictors of secondary RP due to an underlying rheumatologic disease. ...

B-lymphocyte Depletion Using Rituximab in Chronic Fatigue Syndrome/ Myalgic Encephalopathy (CFS/ME). A Randomized Phase-III Study. (RituxME) Sub...

Work as solo NVC facilitator: The day was inspirational for us all. We have shared the learning with our psychologist and have agreed to use needs and feelings to help us understand more about behaviours as we discuss our clients issues at our psychology sessions. We are also incorporating this into supervision and some of…

I am a guinea pig. By this, I mean Im early on the boat when it comes to Low Dose Immunotherapy or LDI, which is considered by many to be the most promising new Lyme treatment to come along in years. In a nutshell, these are the LDI facts. It was pioneered nearly two years…

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