TY - GEN. T1 - Effect of particle size on densification of copper powder during electric-field activated sintering for micro-scale forming. AU - Huang, Kunlan. AU - Qin, Yi. AU - Yang, Yi. PY - 2014/9/9. Y1 - 2014/9/9. N2 - A novel Micro-forming technology, called electric-field activated sintering for micro-scale forming (Micro-FAST), was introduced for the forming of micro-components. The effect of particle size on densification is revealed for copper powder being sintered under the influence from electrical field and force-field during forming of micro-components. Three kinds of copper powders of different particle sizes ((i) average particle size of 0.5μm; (ii) average particle size of 30μm and (iii) the mixture powders with 20% weight of 30μm and 80% weight of 0.5μm) with no binder were used for the experiments. The results show that the density of the compact sintered with mixed copper powders is the largest due to more volume of liquid phase was formed in the particles contacts. The ...

This study applied time lapse (4D) synchrotron X-ray computed tomography (SRXCT) to observe micro-scale interactions between plant roots and soil. Functionally contrasting maize root tips were repeatedly imaged during ingress into soil columns of varying water content and compaction. This yielded sequences of 3D densiometric data, representing time -resolved geometric soil and root configurations at the micron-scale. These data were used as inputs for two full-field kinematic quantification methods, which enabled the analysis of 3D soil deformation around elongating roots. Discrete object tracking was used to track rigid mineral grains, whilst continuum Digital Volume Correlation (DVC) was used to track grey-level patterns within local sub-volumes. These techniques both allowed full-field soil displacements to be quantified at an intra-rhizosphere spatial sampling scale of ,300 µm. Significant differences in deformation mechanisms were identified around different phenotypes under different soil ...

Swedish University dissertations (essays) about MICRO-SCALE MANIPULATION. Search and download thousands of Swedish university dissertations. Full text. Free.

Modular tissue engineering involves the construction of large (macro-scale) tissue structures from smaller (micro-scale) tissue units or modules. The field has the potential to solve various cell-density related challenges associated with traditional tissue engineering. Previous studies have demonstrated the value of vascularization enhancing strategies as a necessary component in bone defect regeneration. In this study, we investigated the fabrication of macro-scale, bone-like constructs by fusion of micro-scale modular units composed of natural polyelectrolyte polymers, hydroxyapatite (HAP) granules, and mesenchymal stem cells (MSCs). The micro-scale modules were formed by complex coacervation whereby an ionic reaction between chondroitin 4-sulfate (C4S) and chitosan produced an insoluble polyelectrolyte membrane. Briefly, a C4S solution with suspended MSCs and HAP granules was extruded as 400 micron diameter droplets and collected into stirred chitosan solution. The insoluble polyelectrolyte ...

Theurillat, Regula; Sandbaumhüter, Friederike A; Bettschart-Wolfensberger, Regula; Thormann, Wolfgang (2016). Microassay for ketamine and metabolites in plasma and serum based on enantioselective capillary electrophoresis with highly sulfated γ-cyclodextrin and electrokinetic analyte injection. Electrophoresis, 37(9):1129-1138. ...

Amongst these, intensive methods of food production have to be cited, as well as the ongoing growth in industrial food products and which moves the world of commerce, and the increasing distances for transport of food and storage times thereof, together with the increase in human mobility. It should be highlighted that the use of this system, still at the development stage, will have a clear social impact in enhancing food safety, given that it will greatly facilitate locating points of contamination. This advance will also contribute to reducing health costs arising from outbreaks of food poisoning, due to its preventative nature. Thanks to the mentioned capacity of the device to typify ...

In the test sample with no pathogen present, the DNAzymes remain inactive and the linkers remain intact. They bind to a GNP at each end and link the GNPs into larger aggregates, causing the solution to turn blue-violet. In contrast, if there is pathogen in the sample, the DNAzymes are activated and proceed to split the linkers. Now only the bridging parts of the linker can bind to DNA strands of the GNPs, so they cannot link the GNPs together. The solution stays red. Because every activated DNAzyme splits many linkers, it amplifies the signal. ...

Trends such as rising global population, changes in the environment, and the growing accessibility of tools for genetic engineering mean that our armed forces are increasingly likely to face new bacterial pathogens, whether they occur naturally or are engineered by adversaries, Paul Sheehan, the program manager for the Friend or Foe technology, said. Our existing biosurveillance strategies dont work on previously undiscovered bacteria or on bacteria that have been specifically designed to evade detection by current tests. We need new screening tools that can quickly characterize the threat to enable a rapid response ...

Copyright in the material you requested is held by the American Society of Mechanical Engineers (unless otherwise noted). This email ability is provided as a courtesy, and by using it you agree that you are requesting the material solely for personal, non-commercial use, and that it is subject to the American Society of Mechanical Engineers Terms of Use. The information provided in order to email this topic will not be used to send unsolicited email, nor will it be furnished to third parties. Please refer to the American Society of Mechanical Engineers Privacy Policy for further information ...

Proteoglycan (PG) and glycosaminoglycan (GAG) samples corresponding to a minimum of 10 ng of uronic acid were reliably quantified as precipitates with the cationic dye Safranin O, collected by vacuum-aided filtration onto a cellulose acetate/nitrate membrane in a standard 96-well dot assay apparatus. The reflectances of the precipitation dots were measured by automatic densitometric scanning of the membrane sheets. Standard GAGs produced reflectance values which were related to the number of anionic groups per unit disaccharide; hyaluronate and keratan sulfate gave lower values while heparin yielded values higher than those of chondroitin sulfates. The presence of 8 m urea, 1% Triton X-100, 30% sucrose, 0.02% NaN3, or mixtures of proteinase inhibitors and various buffers did not markedly influence the reflectances, while 4 m guanidinium chloride and 3 m CsCl reduced the sensitivity of the assay to 30-50 ng. Samples containing sodium dodecyl sulfate (SDS) were not applicable because SDS ...

The PerkinElmer GC Ultramicro Volume Syringe: Capacity 1.0 µL, Needle Gauge 23 (1/Pack) is individually inspected for accuracy and performance.

BioAssay record AID 190228 submitted by ChEMBL: Effect of compound was measured on serum alpha-lipoprotein in male Dawley rats at the dose of 0.4 mmol/kg (day-1)..

Proteome profiling offers new levels of information about cellular identity and regulation that can be missed with genomics or transcriptomics alone. The generation of genome-wide protein measurements, however, is often limited by the amount of input needed for deep and high-quality proteomic profiling. Here, we show improved sample preparation strategies for MS-based proteomic analysis of low cellular inputs from FAC-sorted cells. Using these low input proteomics methods, we were able to quantify over 7000 protein groups analyzing half of the 300,000 freshly isolated mouse immune cell-type collected directly from FACS.. The sensitivity of our low input methodology derives from a combination of three main improvements: fabrication of collection microreactors for easy cell collection and digestion; on-column TMT labeling coupled with desalting for faster and more efficient peptide labeling; and optimized small-scale fractionation of TMT-labeled peptides. The microreactors provided a versatile ...

The kinetic parameters of a reaction, know to follow a Ping Pong Bi Bi mechanism with alcohol inhibition, were determined on micro and bench scale. The effect of temperature on activity and denaturation was also investigated.. Lipase B from Candida antarctica was used to catalyze the esterification of 1-butanol and propionic acid in a water/decane two phase system. On bench scale this was done by end-over-end rotation. On micro scale, a 1.18 m long micro channel with a cross section of 40 x 85 µm facilitated residence times from 45 seconds to 10 minutes. The initial enzyme activity at different substrate concentrations was determined by measuring the ester concentration (product) over time.. The kinetic parameters of this reaction were determined on both scales and showed no significant differences. Parity plots of experimental versus model results are shown in figure 3. The activation energies of activation and denaturation were determined on bench scale and then applied on micro scale. ...

Benetti, E.M., Sui, X., Zapotoczny, S., Vancso, G.J. Surface-Grafted Gel-Brush/Metal Nanoparticle Hybrids, Adv. Funct. Mater.,20, 939 - 944 (2010). Chen, Q., Schönherr, H., Vancso, G.J. Encapsulation and Release of Molecular Cargos via Temperature-Induced Vesicle-To-Micelle Transitions,Small, 23, 2762 - 2768 (2010). Chen, Q., Rausch, K.G., Schönherr, H., Vancso, G.J. a-Chymotrypsin-Catalyzed Reaction Confined in Block-Copolymer Vesicles, Chemphyschem, 11, 3534 - 3540 (2010). Costantini, F., Benetti, Reinhoudt, D.N., Huskens, J., Vancso, G.J., Verboom, W. Enzyme-functionalized polymer brush films on the inner wall of silicon-glass microreactors with tunable biocatalytic activity, Lab on a Chip, 10,3407 - 3412 (2010). Costantini, F., Benetti, E.M., Tiggelaar, R.M., Gardeniers, H.J.G.E., Reinhoudt, D.N., Huskens, J.,Vancso, G.J., Verboom, W. A Brush-Gel/Metal Nanoparticle Hybrid Film as an Efficient Supported Catalyst in Glass Microreactors, Chem. Eur.J., 16,12406 - 12411 (2010). Dorokhin, D., ...

A two-stage microreactor continuous flow system allows the handling organic azides safely in small hold-up volumes with immediate conversion in the 2nd microreactor. In the 1st microreactor the azide intermediate is formed by nucleophilic substitution.1 The azide intermediate is submitted to Staudinger hydration with triphenylphosphine in a subsequent 2nd microreactor. Notably, it is possible to work with biphasic systems in microreactors. A phase transfer catalyst moderates the initial reaction with efficient mixing by the microreactor. Production capacity of o-Xylylenediamine (711462) in two subsequent glass microreactors exceeds 1 kg per day with an overall yield of 60%. Work-up and isolation of the potentially hazardous intermediate is completely avoided between reaction steps, saving time, money and offering scale-independent safety levels. back to top ...

El desarrollo de nuevos procedimientos analíticos e instrumentación automáticos para la monitorización de parámetros (bio)químicos, tales como los que afectan a la calidad del agua, es de especial importancia debido a las graves consecuencias que puede tener el uso o consumo de un agua (bio)químicamente contaminada. Los microsistemas de análisis total o dispositivos Lab-On-a-Chip son cada vez más empleados con este propósito debido a la gran integración y automatización que ofrecen estos dispositivos, a través de la miniaturización, y a la posibilidad de realizar medidas in situ. Por otro lado, el uso de nanopartículas con fines analíticos ha demostrado mejorar la sensibilidad y límites de detección de métodos ópticos. Así, esta tesis se centra en el desarrollo de microsistemas analíticos automatizados que llevan a cabo análisis colorimétricos o fluorimétricos, basados en el uso de nanopartículas como marcadores ópticos, para la rápida detección de analitos o ...

A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.

Microarrays have revolutionized many areas of biology due to our technical ability to quantify tens of thousands of transcripts within a single experiment. However, there are still many areas that cannot benefit from this technology due to the amount of biological material needed for microarray analysis. In response to this demand, chemistries have been developed that boast the capability of generating targets from nanogram amounts of total RnA, reflecting minimal amounts of biological material, on the order of several hundred or thousand cells. Herein, we describe the evaluation of four chemistries for RnA amplification in terms of reproducibility, sensitivity, accuracy, and comparability to results from a single round of T7 amplification. No evidence for false-positive measurements of differential expression was observed. In contrast, clear differences between chemistries in sensitivity and accuracy were detected. PCR validation showed an interaction of probe sequence on the array and target ...

By transporting stem cell clusters through a micro-scale, spiral-shaped device, researchers can safely isolate single stem cells.

Nano-scale or micro-scale adhesive structures comprising an array of nano-fabricated, pillars, the pillars having coated upon, or having disposed on a working surface thereof, a protein-mimetic, marine-adhesive coating. Methods of fabricating the nano-scale pillars, synthesis of the protein-mimetic coating or wet adhesive and application of the adhesive to the pillars are described.

At the micro-scale the brain is a mess; a thick tangle of nerve cells connected at synapses. Mapping just a tiny portion of this mess, a few hundred cells, is a

New research has produced the first micro-scale, in-situ, real-time observations of structural changes within alloys when under extremely high temperatures and stress.

The TargetAmp 2-round biotin-aRNA amplification kit 3.0 from Epicentre Biotechnologies produces microgram amounts of biotin-aRNA (cRNA) from as little

The essential nutrient selenium is required in microgram amounts [recommended dietary allowance (RDA) = 55 μg/day, 699 nmol/day] and has a narrow margin of safety (upper tolerable intake...

Optimizing current chemical processes alone does not yield the improvements required in the fine chemical and pharmaceutical industries. At least partially, a switch from batch to continuous manufacturing is needed. Cost-, time-, and atom-efficient routes frequently demand the application of high temperatures, pressures, and concentrations, and/or the use of highly reactive reagents. These chemistries often cannot be employed in conventional reactors. Costly and long alternative synthetic routes are chosen instead. The application of continuous-flow microreactors allows to access harsh or hazardous reaction conditions and, furthermore, enables entirely new transformations. ...

Flow chemistry specialist Uniqsis, based in Cambridge, UK, and Boston, MA, USA, supplies FlowSyn continuous flow reactors (also known as plug flow reactors, micro flow reactors or microreactors) for pharma and scale up chemistry applications

Using a Syrris flow system and glass microreactors, researchers at the Norwegian University of Life Sciences and SINTEF Materials and Chemistry have demonstrated a novel method for the dibromo-cyclopropanation of alkenes via a continuous two-phase method.. Gem-Dibromocyclopropanes are versatile intermediates in the synthesis of many natural products and are usually prepared via a two-phased catalyzed dihalocyclopropanation of alkenes.. The introduction of two immiscible phases into a microreactor generates a large specific interface area with two distinct, alternating phases. The mass transfer within a microreactor is further increased by the internal circulation within the alternating slugs. Reactions of this type carried out under flow conditions contribute not only to increased mass transfer but increased rates and better selectivity.. Using this methodology the group obtained gem-dibromo-cyclopropanes in good to excellent yields in less time than the equivalent batch reaction across a ...

The MicroChem Kit for Kids includes 17 lessons & experiments to teach students microchemistry concepts & laws. Chemicals, goggles & manual included. Ages 12+.

A novel Micro-forming technology, called electric-field activated sintering for micro-scale forming (Micro-FAST), was introduced for the forming of micro-components. The effect of particle size on densification is revealed for copper powder being sintered under the influence from electrical field and force-field during forming of micro-components. Three kinds of copper powders of different particle sizes ((i) average particle size of 0.5μm; (ii) average particle size of 30μm and (iii) the mixture powders with 20% weight of 30μm and 80% weight of 0.5μm) with no binder were used for the experiments. The results show that the density of the compact sintered with mixed copper powders is the largest due to more volume of liquid phase was formed in the particles contacts. The result being in correspondence with the analytical results of computer simulation. The new understanding developed would help to better quality control during the sintering of micro-components.. ...

Consensus standards are being developed at ASTM International to identify potential emissions from spray polyurethane foam (SPF) insulation products and to evaluate their impact on indoor air quality after installation. A method is currently being developed to measure emissions of SPF insulation using micro-scale chambers. In order to evaluate emission decay rates and the effects of temperature, generic SPF formulations (closed-cell and open-cell) were tested for emissions in micro-scale chambers (0.114 L) at ambient (23°C) and two elevated temperatures (40 and 65°C) for 20 days. Small-scale chamber (36-L) tests were conducted simultaneously to correlate the emission factors that were measured with the micro-scale chambers. Thermal desorption gas chromatography-mass spectrometry was used to capture and quantitate target volatile organic compounds (blowing agents, amine catalysts, etc.) and the flame retardant used in both formulations. Aldehydes were captured onto silica gel sorbent tubes with ...

TY - CHAP. T1 - Information Requirements of Collision-Based Micromanipulation. AU - Nilles, Alexandra Q.. AU - Pervan, Ana. AU - Berrueta, Thomas A.. AU - Murphey, Todd D.. AU - LaValle, Steven M.. N1 - Publisher Copyright: © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.. PY - 2021. Y1 - 2021. N2 - We present a task-centered formal analysis of the relative power of several robot designs, inspired by the unique properties and constraints of micro-scale robotic systems. Our task of interest is object manipulation because it is a fundamental prerequisite for more complex applications such as micro-scale assembly or cell manipulation. Motivated by the difficulty in observing and controlling agents at the micro-scale, we focus on the design of boundary interactions: the robots motion strategy when it collides with objects or the environment boundary, otherwise known as a bounce rule. We present minimal conditions on the sensing, memory, and actuation requirements ...

0092] Microfabricated microreactors (MFMR) were designed and developed using established and novel microfabrication techniques. The process was adopted for the steps, to create circular passages, that resemble those of recent microfabrication of passages in various substrates (Bu et al., A New Masking Technology for Deep Glass Etching and Its Microfluidic Application, Sens. Actuator A-Phys. 115:476-82 (2004); Grosse et al., Deep Wet Etching of Fused Silica Glass for Hollow Capillary Optical Leaky Waveguides in Microfluidic Devices, Journal of Micromechanics and Microengineering 11:257-62 (2001); Iliescu et al., On the Wet Etching of Pyrex Glass, Sens. Actuator A-Phys. 143:154-61 (2008); Iliescu et al., Characterization of Masking Layers for Deep Wet Etching of Glass in an Improved HF/HCl Solution, Surf. Coat. Technol. 198:314-8 (2005); Iliescu et al., Strategies in Deep Wet Etching of Pyrex glass, Sens. Actuator A-Phys. 133:395-400 (2007); and U.S. Pat. No. 5,575,929 to Yu et al., ...

article{6f13846c-aa8b-42e1-974a-d3eeba3d4aea, abstract = {The catalytic performance of porous silicon (PS) micro enzyme reactors (muIMER) is strongly dependent on the PS matrix morphology for enzyme immobilisation. PS was achieved in the muIMER by anodisation in a HF-ethanol mixture. PS etching of structured silicon surfaces commonly results in an inhomogeneous pore formation. The deep channel microreactors described herein have previously suffered from these phenomena, yielding non-optimised muIMERs. In order to obtain a homogeneous PS layer on the deep microreactor channel walls, different reactor geometries (channel wall thicknesses of 50 and 75 mum) were anodised at 10 and 50 mA cm(-2) for anodisation times ranging between 0 and 50 min. The muIMERs were evaluated by immobilising two types of enzymes, glucose oxidase (GOx) and trypsin, and the resulting catalytic turnover was monitored by a colorimetric assay. It was found that reactors with a homogeneous PS matrix displayed improved ...

Samples of gravity cores recovered from Yakutat Bay and Glacier Bay in southeast Alaska were examined in thin section. The samples, representing rhythmically laminated plume deposits, current-derived silts and sands, and iceberg-rafted diamicts, exhibit microstructures indicative of vertical deformation such as loading and water escape, as well as boudinage and other features, which are indicative of simple shear deformation.. Narrow zones in many of the fine-grained core intervals show subtle patterns of preferred clay-mineral orientations (plasmic fabrics). We interpret these intervals as being low-strain simple shear zones. They all show a consistent and regular internal configuration that is formed by sets of conjugate shear planes. The setting and conditions in the Alaskan fjords allow the assumption that the shear zones are exclusively associated with penecontemporaneous movements of the unconsolidated sediment on subaqueous slopes. Analyzing characteristics and trends relating to symmetry ...

Fig. 2. Schematic of the two-point bending test. (A) The test specimen (rachis) is fixed to an aluminum block that in turn is mounted to a micro-manipulator (not shown). The rachis is positioned at a defined length (l) above a micro-scale. (B) Rising forces (F) are measured with the micro-scale after displacing the rachis a defined distance, w(x). At the contact point of the rachis, a metal membrane is flexibly fixed onto the scale pan.. ...

Summary A quantal microassay for the titration of LCM virus strains is described. It is based on the detection of virus-specific complement-fixing antigen in the medium of infected L cell microcultures.

The first part of the paper deals with the quantitative separation of gases by fractional adsorption, the theoretical conditions of which had to be investigated before a really accurate helium analysis could be undertaken. The second part describes the micro-method and apparatus used for the determination of the helium and neon contents of atmospheric air, and discusses questions affecting the accuracy of the results, especially with respect to the samples obtained from the stratosphere (see preceding paper). Figures are given for the most reliable absolute values of the helium and neon contents of atmospheric air: 5.239 + 0.004 and 18.21 + 0/04 parts per million respectively. ...

A method of screening protein crystal growth conditions with picogram to microgram amounts of protein in picoliter or nanoliter volumes is provided. A preferred method comprises a microarray with a plurality of micro-chambers in the microarray. A protein solution is placed into the micro-chambers by an automated dispensing mechanism. The protein crystal growth conditions of each of the micro-chambers is adjusted so that the protein crystal growth conditions in at least two of the micro-chambers differs. Crystallization of the protein solution in the micro-chambers is effected. Protein crystal growth in the micro-chambers is then observed.

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Microflow photochemistry combines successfully the benefits of microscopic dimensions and flow operation. The results from our studies show clearly the superiority of this novel technology over conventional reactor systems. In contrast to commercially available closed microreactors with fixed inner dimension, flexible open microcapillaries allow for task specific applications. Advanced multi-capillary flow reactors furthermore enable parallel operations. It is hoped that this technology will find future applications in chemical R&D processes.. ...

Emax ImmunoAssay Systems, Promega - Each : Dectect picogram levels of the neurotrophic and growth factors per milliliter of sample using these system

The experimental system consists of a stainless steel fixed-bed tubular micro-scale reactor, with an inner diameter of 9 mm, 30 cm long and an updraft flow of the feed. The bed contains a mixture of inert sand and catalyst and is placed inside the reactor upon a porous plate in order to conduct catalytic test. The total pressure of the system is reached with a N2 carrier gas. Nitrogen is also used as a carrier gas and as an internal standard in the gas analyses. The aqueous solution of oxygenated compounds is fed by means of a high performance liquid chromatography (HPLC) pump. When the liquid flow exits the reactor is despressurized and cooled at atmospheric pressure by means of a Peltier cooler, where a condensable phase is recovered. The gas product is separated by means of a Peltier cooler and analysed online with a micro-GC, where N2, H2, CH4, CO2, CO, C2H6, C2H4, C2H2, C3H8 are quantified. The liquid products are collected and analysed offline in the lab by means of a GC equipped with a ...

The soft lithographic technique is a collection of simple and cost-effective patterning techniques which applies an elastomeric stamp to transfer a nano/micro-scale pattern. Patterning biological materials using soft lithography provides procedurally simple control of the surface chemistry and the cell envir Korean Microfluidics

ABSTRACT: Pancreatic cancer is the fourth most common cause of cancer related death in the United States, with a five year survival rate of only 4%. We have recently shown that circulating pancreatic cells (CPCs) can be detected in the blood at the onset of the disease cycle in both mice and humans. These findings present an opportunity to develop a non-invasive diagnostic for pancreatic cancer that has enormous potential to improve patient outcomes. The current gold-standard for circulating tumor cell (CTC) detection fails to measure the extremely sparse and heterogeneous CPCs. Even next generation microfluidic technologies, which do not rely on epithelial markers, have limited utility due to the inherently low-throughput of microfluidics and the large sample volumes of blood (V , 10 mL) necessary for ultra-rare cell detection. To address these challenges, we are developing a new approach to rare cell detection, using magnetic micropores, which combines the benefits of micro-scale sorting with ...

We have summarized methodology of solvent extraction, thin-layer (TLC) and gas chromatography (GLC) techniques appropriate for the separation and quantitative determination of cannabis plant constituents. The cannabis plant constituents studied include delta-l-tetrahydrocannabinol (Δ-1-THC), delta-6-tetrahydrocannabinol (Δ-6-THC), delta-l-tetrahydrocan-nabinol acetate (Δ-1-THC-acetate), Δ-6-THC-acetate, cannabinol and cannabidiolic acid (1). These micro methods were developed to help in solving the following problems:

Workstations with automated liquid handling modules are used for high throughput parallel protein purification. Different chromatographic systems are available for large, analytical and micro-scale purification of proteins and macromolecular complexes using a variety of prepacked columns and chromatography media. The flow rates are flexible in the range 0.001 ml/min to 10ml/min depending on the pump and column specificities. Samples are loaded manually on the column using a syringe or automatically using a loading pump. Proteins are detected as they are eluted from the column by their UV absorption at multiple wavelengths in the range 190-700 nm. Samples are collected in microplates or in a variety of test tube sizes. Fixed volume fractionation or automatic peak fractionation is possible.. ...

The size-dependent static deflection, pull-in instability and resonant frequency of a circular microplate under capillary force have been studied using modified couple stress elasticity theory. Size-dependency is a phenomenon in which the normalized quantities that classical elasticity theory predicts to be independent of the structure size, such as normalized deflection or normalized frequency, vary significantly as the structure size changes. This phenomenon has been observed in micro-scale structures such as micro-electro-mechanical-systems (MEMS). Since classical elasticity theory is unable to predict the size-dependency, non-classical elasticity theories such as modified couple stress theory have been developed recently.. In this paper, modified couple stress theory is used for the first time to develop the governing equation and boundary conditions of circular microplates when subjected to capillary force. Consideration of capillary force is important since it is has a significant role in ...

Conference (2017, November 07). The purpose of this work is to generate Stochastic Volume Element (SVE) of unidirectional composites using statistical information obtained from imaging technique in order to study the effect of the micro ... [more ▼]. The purpose of this work is to generate Stochastic Volume Element (SVE) of unidirectional composites using statistical information obtained from imaging technique in order to study the effect of the micro-structure uncertainty on the meso-scale behavior. When considering a homogenization-based multiscale approach, the material properties are obtained at each integration point of a macro-structure from the resolution of a micro-scale boundary value problem. When the separation of scales holds, the macro-point is viewed at the micro-level as the center of a Representative Volume Element (RVE). However, for composite materials which suffer from a large scatter in their constituent properties and microstructure, the separation of scales does not ...

Research interests== Proteomic Analysis of Connective Tissue Sarcoma: We have developed methods for proteomic analysis of formalin-fixed, paraffin embedded (FFPE) dense connective tissues (bone, cartilage and tumors). Our unique methods of protein extraction are coupled with mass spectrometry for proteomic analyses. These powerful methods, and the use of archival tissues, allow us to evaluate even rare musculoskeletal tumors. In this way, we are able to carry out translational research that directly addresses questions of clinical orthopaedic oncology. Metastatic Mechanisms of Osteosarcoma: We are investigating integrin mediated and matrix metalloproteinase (MMP) dependent mechanisms of osteosarcoma metastasis using genetically modified cells and an in vivo model. Polymer Scaffolds for Cellular Attachment: We are evaluating cellular attachment to and proliferation on various nano- and micro-scale topologies made with the polymer parylene C. This work is being carried out in collaboration with ...

The standard for mastering heat and mass transfer Respected for its readability, comprehensiveness, and relevance, Incropera and DeWitts text is the recognized standard for learning heat and mass transfer. This text combines detailed coverage with the resources students need to learn the concepts and apply them to solving realistic and relevant problems. Using a rigorous and systematic problem-solving methodology, the text is filled with examples and problems that reveal the richness and beauty of the discipline. The 6th Edition introduces coauthors Ted Bergman and Adrienne Lavine, who bring their record of success in teaching and research in heat and mass transfer to the text. New Features Expanded coverage of areas of recent interest in heat transfer, including fuel cells and alternative energy devices, electronics cooling, micro-scale heat transfer, and biological as well as bioheat transfer. New examples and homework problems are included for each area. Introduction to the concepts of ...

Shelly carbonate sands represent an extreme soil type in terms of their mechanical behavior which derives from the bioclastic nature of the constituent grains. In their uncemented form, these deposits exhibit very high compressibility, which has posed a number of geotechnical engineering problems; in most cases related to the reduction in the bearing capacities of both shallow and deep foundations. Remarkable features of these carbonate sands include the complex shape and the structural weakness of the grains and the high inter and intra granular porosity. Previous studies, have quoted the interlocking of the angular shelly particles to be at the origin of their high friction angles and high initial void ratio, however, up until now, no scientific micro-scale examination has been carried out. This paper presents a non-invasive image based investigation into the grain morphology of a carbonate sand from the Persian Gulf. This sand has a median grain size of 570μm and a high CaCO3 content in the ...

Design of bio-inspired functional materials that serve as new tools in precision medicine. Understanding how peptides and proteins assemble at natural and non-natural interfaces to form organized structures with unique biochemical functions. The design of nano- and micro-scale biomaterials to develop new biosensing and therapeutic strategies to treat infectious disease, inflammation and cancer. ...

All the Action is Down there on the Micro-scale: A curious feature of the oceanic food chain is that if the organisms are organised in logarithmical bands of size, (e.g. 1-10 mm, 10-100 mm, 100-1000 mm etc) then in a given volume of ocean water (say a cubic kilometre) there is approximately an equal amount of biomass throughout the size ranges - thus in that volume the biomass of organisms of the size range 1-10 microns (marine microorganisms - bacteria and protozoa) is similar to that of organisms 1-10 metres (the larger fish and most of the whales). This contrasts sharply with the terrestrial system where there is a reduction of biomass as you ascend the food chain - the so-called Eltonian Pyramid (no not the piano player with funny glasses). Digging Deeper into the Science: The significance of constancy in biomass with size in the plankton becomes apparent when we take into consideration a second general law in biology - that the specific metabolic rate (the rate of metabolism of an organism ...

Research in our lab focuses on developing novel functional optical imaging and manipulation techniques to address biomedical questions that have been difficult or impossible to approach with traditional methods. Current major applications are in reproductive biomedicine and micro-scale biomechanics.. We look for talented and self-motivated people to join us. Openings are available for Ph.D. students. Please contact Shang for details. ...

A method of introducing biological material into cells includes providing one or more target cells and establishing a spray of substantially dispersed particles including biological material. The substantially dispersed particles have an electrical charge applied thereto such that one or,more of the substantially dispersed particles of the spray is introduced into one or more of the target cells. The spray of substantially dispersed particles may be established by dispensing a spray of microdroplets suspending particles. The electrical charge is concentrated on the suspended particles as the microdroplet evaporates. The suspended particles may include carrier particles with biological material or the suspended particles may be particles of biological material alone. The space charge effect of the concentrated electrical charge on the substantially dispersed particles of the spray enable one or more of the particles to be introduced into one or more of the target cells. An apparatus for introducing

Sigmas GenomePlex Whole Genome Amplification (WGA) kit utilizes a proprietary amplification method designed for robust and accurate amplification of limited source DNA. In less than three hours, GenomePlex WGA successfully amplifies nanogram amounts of starting DNA, regardless of source, into microgram yields.

Generate stranded, Illumina®-ready cDNA libraries from 250 pg-10 ng of total mammalian RNA using the SMARTer Stranded Total RNA-Seq Kit - Pico Input Mammalian.

Does anoyone think that you can get the most dramatic improvement in depressed acne scarring through using the microdroplet technique numerous times until the depressions are elevated close to the surrounding skin, followd by several sessions of dermbrasion by a wire brush to reduce the shadowing...

In flow chemistry, a chemical reaction is run in a continuously flowing stream rather than in batch production. In other words, pumps move fluid into a tube, and where tubes join one another, the fluids contact one another. If these fluids are reactive, a reaction takes place. Flow chemistry is a well-established technique for use at a large scale when manufacturing large quantities of a given material. However, the term has only been coined recently for its application on a laboratory scale. Often, microreactors are used. Comparing parameters in Batch vs Flow: Reaction stoichiometry. In batch production this is defined by the concentration of chemical reagents and their volumetric ratio. In Flow this is defined by the concentration of reagents and the ratio of their flow rate. Residence time. In batch production this is determined by how long a vessel is held at a given temperature. In flow the volumemetric residence time is used given by the ratio of volume of the reactor and the overall flow ...

Microreactors have gained increasing attention in their application toward continuous micro flow synthesis. An unsolved problem of continuous flow synthesis is the lack of techniques for continuous...

BMG LABTECH is proud to be a Silver Sponsor of the annual Miptec meeting in Basel, Switzerland from September 24th-27th 2012. BMG LABTECH - The Microplate Reader Company - will showcase its newest technology at Miptec 2012, detailing how this technology greatly enhances applications. Stop by Booth #A22 to see unique and proprietary microplate reader technology that separates BMG LABTECH instruments from all of the rest.

The ionKey/MS System integrates the microflow UPLC separation directly into the source of the mass spectrometer with the iKey. This delivers LC-MS system performance and sensitivity that cannot be achieved any other way.

The ionKey/MS System integrates the microflow UPLC separation directly into the source of the mass spectrometer with the iKey. This delivers LC-MS system performance and sensitivity that cannot be achieved any other way.

The generation and reactivity of two model vinyl carbenoids from gem-dibromoalkenes 1 were studied in microflow systems. From substrate 1a (R =

Cytokines Cytokines are a group of regulatory proteins critically involved in many physiological processes such as immune recognition, cell differentiation and cell proliferation. They have been identified in many vertebrate species and are produced by a variety of different cell types. Cytokines are usually produced transiently and locally, acting in a paracrine or autocrine manner. They interact with high affinity cell surface receptors specific for each cytokine or cytokine group and are active at very low concentrations mostly in the picogram range.

Cytokines Cytokines are a group of regulatory proteins critically involved in many physiological processes such as immune recognition, cell differentiation and cell proliferation. They have been identified in many vertebrate species and are produced by a variety of different cell types. Cytokines are usually produced transiently and locally, acting in a paracrine or autocrine manner. They interact with high affinity cell surface receptors specific for each cytokine or cytokine group and are active at very low concentrations mostly in the picogram range.

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Colin R. Jackson is the author of this article in the Journal of Visualized Experiments: Determination of Microbial Extracellular Enzyme Activity in Waters, Soils, and Sediments using High Throughput Microplate Assays