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The last few decades have seen the rise of molecular microbial techniques that allow determining the abundance of microbial players in their natural habitats, their coincidence and their relationships with environmental conditions. These techniques have also provided critical insights in the phylogeny and functional potentials of micro-organisms. Moreover, they contributed new bioinformatics tools to describe the genetic and functional composition of microbial communities However, this information has so far hardly be coupled to microbial physiological principles, which will be essential to provide quantitative, system-level understanding of biogeochemical processes. Microbes play a critical role in driving and modulating biogeochemical processes and many of the ecosystem services delivered by microbes relate to this role. Already half a century ago, Monod and Pirt derived equations to quantitatively describe microbial growth and the rates of microbial biogeochemical conversions of elements.
Work in my laboratory is focussed on microbial physiology - the study of how bacteria and other microorganisms work. Although rooted in the tradition of bacterial growth and intermediary metabolism, microbial physiology now embraces molecular biology, genetics, biochemistry, and indeed any discipline that can shed light on bacterial function. Much of our experimental work is conducted with Escherichia coli, the pre-eminent model organism with unrivalled ease of genetic and physiological ...
73, 6181-6191. , Sivan, A. and Kushmaro, A. (2008) Global distribution and diversity of coral-associated Archaea and their possible role in the coral holobiont nitrogen cycle. Environ. Microbiol. 10, 2979-2990. A. M. (2000) Crenarchaeota colonize terrestrial plant roots. Environ. Microbiol. 2, 495-505. , Wagner, M. and Schleper, C. (2010) Distinct gene set in two different lineages of ammonia-oxidizing archaea supports the phylum Thaumarchaeota. Trends Microbiol. 18, 331-340. , Wagner, M. W. (2008) Diversity and mode of transmission of ammonia-oxidizing archaea in marine sponges. In order to establish infection, resist host defences and re-emerge, Mtb must coordinate its metabolism with the in vivo environmental conditions and nutrient availability within the primary site of infection, the lung. Maintaining metabolic homeostasis for an intracellular pathogen such as Mtb requires a carefully orchestrated series of oxidation-reduction reactions, which, if unbalanced, generate oxidative or ...
Kimura S, Koenig D, Kang J, Yoong FY, Sinha N (2008) Natural variation in leaf morphology results from mutation of a novel KNOX gene. Curr Biol 18(9):672-677 67. Kim M, Pham T, Hamidi A, McCormick S, Kuzoff RK, Sinha N (2003) Reduced leaf complexity in tomato wiry mutants suggests a role for PHAN and KNOX genes in generating compound leaves. Development 130:4405-4415 68. Clayberg CD, Butler L, Kerr EA, Rick CM, Robinson RW (1966) Third list of known genes in the tomato. J Hered 57:189-196 69. Avivi Y, Lev-Yadun S, Morozova N, Libs L, Williams L, Zhao J, Varghese G, Grafi G (2000) Clausa, a tomato mutant with a wide range of phenotypic perturbations, displays a cell type-dependent expression of the homeobox gene LeT6/TKn2. Patens gametophore epidermal cells, namely basal and mid-stem rhizoid, and auxin induces their development (17). The PpHB7 gene (encoding a homeodomain-leucine zipper I transcription factor) is required for rhizoids late differentiation steps, but not for their determination. ...
Schorsch M, Kramer K, Goss T, Eisenhut M, Robinson N, Osman D, Wilde A, Sadaf S, Brückler H, Walder L, Scheibe R, Hase T, Hanke G (2018) A unique ferredoxin acts as a novel player in the low iron response of photosynthetic organisms. Proceedings of the National Academy of Sciences USA (in press). Balevičius V, Fox K, Bricker W, Jurinovich S, Prandi I, Mennucci B, Duffy C (2017). Fine control of chlorophyll-carotenoid interactions defines the functionality of light-harvesting proteins in plants. Scientific Reports. Sacharz J, Giovagnetti V, Ungerer P, Mastrioanni G, Ruban A (2017). The xanthophyll cycle affects reversible PsbS-LHCII interactions to control non-photochemical quenching. Nature Plants. Engl C, Schaefer J, Kotta-Loizou I, Buck M (2016). Cellular and molecular phenotypes depending upon the RNA repair system RtcAB in Escherichia coli. Nucleic Acids Research. Schuergers N, Lenn T, Kampmann R, Meissner M, Esteves T, Temerinac-Ott M, Korvink J, Lowe A, Mullineaux C, Wilde A (2016). ...
Course format: Laboratory (1:25P-5:00P, MW, JH A402) with discussions at the beginning and/or end of labs (TBA in JH 248.) Requirements: C341, L113, M250, M255 or consent of the instructor. Course description: This course will provide an overview of key microbial genetic and biochemical concepts, which are used in today s academic and industrial research settings. Students will become familiar with several methods of gene expression and protein purification, as well as mutagenesis and identification of mutants, characterization of enzymatic activity, and the chemical basis for microbial communication. Required text: Fundamental Lab Approaches for Biochemistry and Biotechnology. New Jersey: John Wiley & Sons, Inc., 1998. Weekly assignments: TBA Exams/papers: TBA ...
El Aidy, S., Stilling, R., Dinan, T. G., & Cryan, J. F. (2016). Microbiome to brain:: Unravelling the multidirectional axes of communication. In M. Lyte (Ed.), Microbial Endocrinology: Interkingdom Signalling in Infectious Diseases and Health (2 ed., Vol. 874, pp. 301-336). (Advances in Experimental Medical Biology; Vol. 874). Springer ...
A range of hosts was used for functional recombinant protein production. E. coli is one of the preferred hosts of choice for the preparation of therapeutic proteins because of its simplicity, fast growth, and low-cost fermentation process [15, 16]. The soluble expression of functional HSA in E. coli is the major difficulty for investigators. In earlier attempts, rHSA was expressed in E. coli but the majority of the protein expressed is insoluble, in the form of inclusion bodies [17, 18]. It is known that the majority of the overexpressed proteins that have hydrophobic patches, undergo post-translational modifications or have disulfide bonds are primarily at the risk to form such amorphous aggregates [21]. HSA is a large multidomain disulfide-rich protein and it is often difficult for a disulfide bond rich protein to fold in its functional form under the normal reducing physiological environment of the E. coli cells.. In the present study, we have targeted and eventually resolved the prime ...
The increased availability of genomic and metagenomic data poses challenges at multiple analysis levels, including visualization of very large-scale microbial and microbial community data paired with rich metadata. We developed GraPhlAn (Graphical Phylogenetic Analysis), a computational tool that produces high-quality, compact visualizations of microbial genomes and metagenomes. This includes phylogenies spanning up to thousands of taxa, annotated with metadata ranging from microbial community abundances to microbial physiology or host and environmental phenotypes. GraPhlAn has been developed as an open-source command-driven tool in order to be easily integrated into complex, publication-quality bioinformatics pipelines. It can be executed either locally or through an online Galaxy web application. We present several examples including taxonomic and phylogenetic visualization of microbial communities, metabolic functions, and biomarker discovery that illustrate GraPhlAns potential for modern microbial
You will be will introduced to microbiology as an applied science. You will also explore principles within biochemistry and will be introduced to basic biochemical concepts. Through data analysis you will gain confidence in the use of general mathematical techniques. Through the biology of disease module you will explore the fundamental concepts of aetiology, pathology and epidemiology. You will learn basic skills required to work in a microbiology laboratory. You will also study parasites in human diseases.. The second year develops your knowledge further. You will be introduced to industrial microbiology enabling you to identify microbiological mediated industrial problems. You will also look at the theoretical and practical microbial physiology with particular reference to ecology, immunology and metabolism. You will also look at the methods, benefits and potential hazards of genetic engineering. You will gain insight into the diversity of pathogenic microorganisms. The work-based learning ...
Meet Global Microbiologists and Physiologists from USA (America), Europe, Middle East and Asia pacific at Microbial Physiology Conferences, Microbiology Conferences, and Genomics Conferences happening from July 16-18, 2018 London, UK
In the post-genomic era microbial physiology and biochemistry are of paramount importance and this module will provide theoretical training in the processes involved in microbial growth and its measurement and control. The content will emphasise the immense diversity of environments that microbes inhabit and how this unlimited source of biological activity can be exploited for biotechnological purposes including specific examples of industrial bioprocesses. Although the emphasis is on the positive benefits of microorganisms, the potential for misuse of microbial biotechnology will also be discussed. ...
I studied Biochemistry at the Technical University of Hannover, Germany graduating with a MSc in Biochemistry in 1989. Subsequently, I obtained my PhD at the same university in 1993. After five years of postdoctoral research at the Medical School of Hannover and the Karolinska Institutet, Stockholm, I was appointed Junior Research Group Leader at the Helmholtz Institute for Infection Research, Braunschweig, Germany in 1998. In 2002, I gained a position as an Associate Professor in Molecular Microbiology at the KI obtaining a 5 year Elitforskartjänst. In 2012, I obtained the position as a Professor in Medical Microbial Physiology at Karolinska Institutet. The major focus of my research is on regulation of biofilm formation in microorganisms, biofilm composition and interaction of biofilms in different environments. I am interested in basic research as well as the clinical and environmental aspects. In addition, we are interested in persistence mechanisms of world-wide spread of Pseudomonas
Microbial nutrition is that aspect of microbial physiology ... Table 1: Nutritional Categories of Microorganisms .... 1: A typical growth curve of a bacterial culture. ..... culture volume, cell number and concentration of nutrients remain constant.... ...
Meet Global Microbiologists and Physiologists from USA (America), Europe, Middle East and Asia pacific at Microbial Physiology Conferences, Microbiology Conferences, and Genomics Conferences happening from July 16-18, 2018 London, UK
The objective of this research project was to further develop a software system called BESS (Biodegradation Evaluation and Simulation System), which can predict the biodegradability of a compound based on the structural features of that compound and the prevailing environmental conditions. The approach pursued in the development of BESS is based on the iterative use of plausible enzymatic transformations that are hierarchically organized based on knowledge of microbial physiology and ecology. This organization reduces the potentially large number of enzymatic transformations that could apply to a compound, making the approach computationally feasible. Further, only those enzymatic transformations that are most likely to provide anabolic intermediates or energy to microorganisms and thus have evolved through processes of natural selection are used. This further reduces the complexity. BESS employs a fundamentally different approach to the prediction of whether a given chemical will undergo ...
I obtained my PhD in 1989 at the Free University (Amsterdam) on a research project in which microbial physiology, biochemistry, and molecular biology were combined. Subsequently I spent 3 years abroad, 2.5 years of which as EMBO fellow at the EMBL (Heidelberg, Germany) where I worked on protein engineering and protein crystallization. I returned to Amsterdam as KNAW fellow for 3 years, during which I worked on protein analysis and pathway engineering. In 1995 I was appointed as group leader ...
I obtained my PhD in 1989 at the Free University (Amsterdam) on a research project in which microbial physiology, biochemistry, and molecular biology were combined. Subsequently I spent 3 years abroad, 2.5 years of which as EMBO fellow at the EMBL (Heidelberg, Germany) where I worked on protein engineering and protein crystallization. I returned to Amsterdam as KNAW fellow for 3 years, during which I worked on protein analysis and pathway engineering. In 1995 I was appointed as group leader ...
Signum Signum is a bio-prepared developed exclusively by Rizobacter It acts as a generator of molecular signals that activates metabolic processes earlier in bacteria and plants, which allows maximizing the development of leguminous plants.. Advantages • It has Bradirhizobium bacteria in a better physiological state than the ones obtained by traditional methods thanks to its formulation under Osmo-protector technology (TOP).. • It is an activator of vegetable and microbial physiology.. • It acts on the germination and crops development.. • It promotes the activity in the rhizosphere.. • Induces diseases resistance by activating defensive signals.. • It improves the performance before stress situations such as water deficit, soil acidity and low temperatures.. • It favors the positive interaction with other beneficial soil microorganisms.. • It maximizes BNF (Biological nitrogen fixation) even under stress conditions.. • It increases grain performance and ...
Research Manager Håvard Sletta - SINTEF Materials and Chemistry, Department of Biotechnology, Trondheim - Norway. The project aims to systematically elucidate the influence of increasing bioreactor inhomogeneity which occurs in industrial-scale bioreactor, with respect to microbial physiology and production performance of Corynebacterium glutamicum, a microorganism with broad industrial applications. Early consideration of inhomogeneity issues during lab scale process development will facilitate the selection of the most potent production strain, accelerate the upscaling process and improve the performance at production scale. Such inhomogeneous conditions can be mimicked at lab scale by a so called scale-down simulator bioreactor, consisting of a well-mixed stirred tank reactor (STR) and a plug-flow reactor (PFR) connected in series to it. During operation the cultivation volume is continuously pumped from the STR through the PFR simulating zones of inhomogeneity known to be present at the ...
So far, progress of microbial physiology has depended on the use of pure cultures. Study of a microbial strain in pure culture was essential to obtain unambiguous results about metabolism, regulation or cell biology, especially when a genetic system or a complete genome sequence was available. Unfortunately, it is also all but impossible to interpret results from physiological studies in ecological context. Indeed, for many highly interesting model organisms, meaningful definition of an ecological niche has defied decades of intensive study. Advances in next generation DNA and RNA sequencing, community proteomics, and metabolomics, in combination with advances in computational procedures are now enabling detailed physiological study of specific bacteria in the context of their natural community. This approach is currently under rapid development and used both directly with natural habitats or on habitats engineered in the laboratory. It provides information about how different bacteria interact,
The evolutionary histories of genomes and of individual genes are important for understanding the genetic basis of microbial physiology. Genes that have a different history than the rest of the genome due to lateral genetic transfer may provide insight into the unique abilities of closely related organisms, but also serve to disrupt inference of the history of organisms by common lineage. Inconsistent results in phylogenetic signal among different genes and derived by different methods illustrate the need for approaches that can utilize multiple genes and clarify phylogenetic signal across entire genomes. Phylogenetic inference based on models of nucleotide and amino acid substitutions has become the standard, but higher level markers such as conserved insertions and deletions (indels), may provide clearer results.; Indels appear as gaps in the alignment of sequences, but high levels of alignment errors associated with gaps have generally meant their exclusion from phylogenetic analysis. Efforts ...
Microbial Physiology. Wiley-Liss. ISBN 0-471-39483-1. Piechaczek C, Fetzer C, Baiker A, Bode J, Lipps HJ (1999). A vector based on the SV40 origin of ...
Read "Ecology and evolution of metabolic cross-feeding interactions in bacteria, Natural Product Reports" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
People need to be reminded that we live in a microbial worldin the Microbes section. Germs and bacteria a catalog of all known germs
This is an entry for the American Society of Microbiology Agar Art competition, and yes, its created using poop! Or more correctly, bacteria from poop. You can see more of the agar art at: http://www.facebook.com/media/set/?set=a.10154367491515200.1073741836.62453295199&type=3 Update: Weve now got a full gallery of our art at http://modmedmicro.nsms.ox.ac.uk/art-from-the-gut/ Theres a lot more behind it than…
**Standard disclaimer: these are my notes taken during the sessions, as accurate as I can make them, please let me know if any inaccuracies. Im putting them here as others have said they found them useful. However worth re-checking anything before you re-quote it. If this continues to be useful, Ill continue. If its clear…
EDITOR-As the rapid responses to Hoffenbergs reminiscences show, the United Kingdom has not been spared misunderstandings and controversy over death and brain function.1 Skegg has chronicled the confusion that followed the report by the conference of Medical Royal Colleges in 1976, when the conference was not asked (nor apparently was it able) to agree whether patients with brain stem … ...
A Postdoc position is available for an immediate start within the project Elucidating symbiotic interactions in the ecologically important marine sponge Ianthella basta - a collaborative project of Nicole Webster from the Australian Institute of Marine Science (AIMS) and Michael Wagner. The position is funded by the ERC Advanced Grant NITRICARE. We are looking for a highly motivated and independent postdoctoral fellow willing to work jointly between the University of Vienna and AIMS. Applicants should have a keen interest in fundamental microbial symbiosis and a strong research background in microbial physiology and environmental microbiology.. ...
BIOL 6150: Genomics and Applied Bioinformatics, 3-0-3: Retrieval and analysis of biological sequence, gene expression, and proteomics data from public databases and other sources; applying standard bioinformatics tools to investigate biological questions. BIOL 6221: Biological Oceanography, 3-0-3: An introduction to the major biological processes in the ocean, including primary production, elemental cycling, food webs, and fisheries.. BIOL 6410: Microbial Ecology, 3-0-3: Advanced studies of microbial ecosystems, the specific roles of bacteria in maintaining ecological balance, and the evolution of the ecosystem in response to changing environments.. BIOL 6417: Marine Ecology, 3-0-3: An overview of the ecological and evolutionary patterns, processes, and mechanisms affecting the organization, structure, and function of a broad variety of marine communities.. BIOL 6418: Microbial Physiology, 3-0-3: Study of the physiology of growth and metabolic activities of microorganisms.. BIOL 6422: ...
Chris Dupont is an Associate Professor in the Microbial and Environmental Genomics group at JCVI. His primary research focus is microbial physiology and the environmental and evolutionary influence on physiological variation. This involves work with model organisms in laboratory systems, domestication of wild microbes for model studies, and sequencing based profiling of microbial communities in a variety of environments, including organismal microbiomes. Dr. Dupont is also working on applying synthetic biology and machine learning techniques to solve unique problems in big dataset associated with the human microbiome and the environment. Dr. Dupont began his career at JCVI as a post-doctoral fellow. He received his Ph.D. in Oceanography from the Scripps Institution of Oceanography, as well as a Bachelors in Natural Resources and a Masters of Biological and Environmental Engineering from Cornell University. ...
ABSTRACT: Vincent Danos is Directeur de Recherches at CNRS, and holds the Chair of Computational Systems Biology at the University of Edinburgh. He works on clean and scaleable domain-specific modeling/programming languages, mostly, but not only, for systems and synthetic biology. He is taking part in cross-disciplinary activities meeting on algorithmic/mathematical structures for modelling (social systems, economical systems, climate, multi-scale plant growth, etc) with the Edinburgh Multidisciplinary Multiscale Modelling initiative. Vincent is one of the organizers of the Lorentz Center workshop Integrative Cell Models; Bridging Microbial Physiology and Systems biology that is being held from 26 Jan 2015 through 30 Jan 2015. ...
There are four major research foci in my laboratory. First, we are interested in elucidating and understanding the molecular mechanisms involved in the survival of pathogenic bacteria in nature and the contribution of these mechanisms to aid these pathogens in their ability to cause human diseases. Second, we are interested in developing peptide based biosensors for rapid detection of important bacterial pathogens. Our biosensors can detect pathogens in just minutes rather than hours or days of other approaches. Third, we have determined that subterranean termite Reticulitermes flavipes possesses ability to produce anti-Pseudomonas and anti-MRSA (methicillin resistant Staphylococcus aureus) activities when they are induced with heat-killed pathogen. We are currently involved in identifying these antibacterial activities from R. flavipes. Finally, we are interested in genetic and metabolic engineering to develop bacterial cells into microbial factory for optimal production of value-added ...
Introduction: The microbial world. Despite suggestions from popular science programmes, planet Earth is not owned by insects (or humans): it is a microbial world. (For the purposes of this article, we classify microbial as including the bacteria and archaea (prokarya), fungi and yeasts (eukarya) and viruses.) Microorganisms inhabit virtually every possible niche on Earth, including those at the outer envelope of survival.1 Deep sea hydrothermal vent waters at 120 oC, the ancient sub-glacial lakes of the permanently frozen Antarctic continent, fractures in geological strata kilometres below our feet, sediments far below the ocean floors and even the clouds far above us are habitats for microbial life. In fact, the only sterile environments on Earth are those where conditions exceed the stability limits of molecular structures, such as in molten volcanic lava.. The total number of microbes on the planet is certainly not known with any accuracy, but estimates suggest ,1x1031 microbial cells.2 ...
It is common to characterize metabolic models by the numbers of reactions and metabolites included, but these can be misleading measures without qualification. One reason is that there is a case during model building for adding more reactions than can be connected to the network. This will arise if a gene is annotated to an enzyme with a broad substrate range (e.g. alcohol dehydrogenase, EC 1.1.1.1), since it will not be clear while the model is incomplete as to which alcohols and aldehydes will be available by being produced or consumed by other enzymes in the network. A simple solution is to add more than is likely to be necessary and to remove at a later stage the ones that are not functional.. What criteria do we have for reactions that are non-functional? One test is where a metabolite is only involved in a single reaction in the network. In this case, the metabolite cannot reach a steady state because it is impossible to have its balanced production and consumption. Furthermore, the ...
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In the 1980s scientists discovered that, despite microbes invisibility to us, the microbial world is much more diverse and numerous than the macroscopic world of plants and animals. Traditional measures of diversity relied on physical traits. The use of physical traits in determing relationships between organisms has two major problems when it comes to microbes: 1) microbes are not as morphologically diverse as metazoans and their morphological traits are not indicative of evolutionary relationships and 2) there are no morphological traits common to both macroorganisms and microbes. In the 1980s Carl Woese suggested that the deoxyribonucleic acid (DNA) sequences of certain common genes could be used to measure relatedness among radically different organisms. He picked the genes that encode ribosomal RNA (rRNA). Ribosomes, the protein-RNA complexes that are the scaffold on which proteins are synthesized, are common to all cells, both prokaryotic and eukaryotic. Despite differences in size, the ...
TopThis module gives an overview of microbial diversity, the biological properties of microbes, methods and approaches in the study of microbiology. At the end of the module, students should have fundamental knowlede of microbiology, incuding tools in the study of cells and microbes and the awareness of biosafety, and students should be excited by the microbial world and wishing to know more. ...
Visual Media Briefs consist of high-quality, short communications with digital images, animations, and videos about the microbial world. Brief content is visually engaging and covers the expanse of ASMs Curriculum Guidelines. Each item includes an introduction, methods, discussion, and reference section. Briefs describe the item and how it was obtained (e.g., cultured and isolated), its significance and/or use, magnification, and references. Visual Media Briefs are similar to short research communications (or briefs) in scientific journals and can be used to enhance presentations. Content is free, original, open access, and peer-reviewed by the microbiology educator community. Visual Media Brief content was published between 2007 and 2014.. ...
Humankind has a delicate and intricate set of relationships with a microbial world of astonishing diversity. In recent times, these relationships have become increasingly strained, reflecting the emergence of new pathogens as agents of naturally occurring disease as well as the possibility that some microorganisms could be deliberately used to cause harm. Faced with this situation and the imperative of developing public-health countermeasures, it is a natural desire to begin to organize, categorize and prioritize these threats. A common feature of such efforts is the generation of a list, sometimes in rank-descending order on the basis of importance or some other metric. A list gives the appearance that one has bounded and specified an issue or problem and can suggest or define priorities. But lists are, by their nature, incomplete and, more impor- tantly, they can inappropriately limit creative or broad thinking as well as subtly mislead viewers into organizing their world view in. a narrow and ...
From garden to gut, David R. Montgomery, PhD, University of Washington, Earth and Space Sciences, and Anne Bikle, MLA, Biologist and Environmental Planner, will present a new view of the tiniest creatures on Earth and how it is changing the way we see nature and ourselves. Through the twists and turns of history, science, and personal experience, theyll reveal our tangled relationship with the microbial world, including the stunning similarities between whats going on around the roots of plants and deep within the human gut.. Fee: Free member and student, $10 nonmember. Register at my.arboretum.harvard.edu or call 617-384-5277.. ...
Jeremy Berg: "I recently have started to work on the next edition of "Biochemistry," the textbook first written by Lubert Stryer. The initiation of the revision process is always a bit daunting, but it is a great occasion to take stock of progress across the entire field of biochemistry. In my survey, four facets stood out: newly appreciated roles for RNA; an increased interest in the importance of metabolism; the ever-growing knowledge of the vastness of the microbial world, including the human microbiome; and the structures and mechanisms of action of membrane proteins. I will focus on the last topic here." ...
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... is dedicated to publish research papers, reviews, and short communications in all areas of Microbiology such as virology, mycology, parasitology, bacteriology, clinical microbiology, phycology, parasitology, protozoology, microbial physiology, immunology, microbial genetics, medical microbiology
At all stages of the disease process, bacteria must acquire nutrients from the surrounding microenvironment to sustain growth and replication. Recent findings from genetic screening methods to identify factors required for bacterial pathogenesis in vivo have served to emphasize the essential role of microbial physiology during pathogenesis (25, 35).. N. gonorrhoeae has stringent nutrient requirements for growth. Only a limited repertoire of carbon energy sources, including glucose and lactate, are effectively utilized by this bacterium (2). Both are available in the genital tract, the normal habitat of N. gonorrhoeae. While biochemical evidence has demonstrated the effect of additional lactate on gonococcal metabolism and resistance against complement, this is the first description of a strain of N. gonorrhoeae that is specifically unable to utilize this carbon source. This was achieved by taking advantage of the recent identification of the gene encoding the lactate permease in the related ...
Some mechanisms of diversification involve ecological interactions exhibited as frequency-dependence [11]. This includes niche creation [11, 12] and frequency-dependent coexistence due to cross-feeding, where the cross-feeder organism is maintained in balance with the producer [59], or through cannibalism of one or the other coexisting type [28]. Another frequency-dependent scenario is when two or more resources in a system result in specialization of different bacteria on different resources in the same environment [11, 60]. None of these ecological scenarios are readily extended to the current studies. Cross-feeding and cannibalism do not appear to have evolved in the chemostats, probably because the time-scale is relatively short. None of the sequenced mutations hint at cross-feeding, such as the acs mutation noted in [8]. There is no evidence for multiple resources, multiple niches or mutations enhancing uptake or regulation of alternative carbon sources besides glucose. Nevertheless, ...
While a first step in studying ecosystems is the identification of their members, a subsequent and important aspect is the analysis of what each organism is doing. Determining the in situ activity is a challenging issue, given that the majority of microbes escape cultivation. Microbes cannot be easy singled out and there is a wealth of biotic and abiotic interactions in the complex intestinal ecosystem.. Microbial activity can be measured using a variety of targets, such as cells, their constituent RNAs, proteins or metabolites, or using reporter systems (Table 1). Whatever target one selects, it must be realized that the detection spans of these targets differ considerably. Most transcriptome studies are, in fact, snapshots of the present as they monitor steady state concentrations of mRNAs. However, genetic approaches might also provide a picture of transcriptional activity in the past (see below). Similarly, proteins have a higher half-time than mRNAs, which can be exploited in promoter ...
The mayor of Krakow announced on Monday that he will seek the consent of locals on whether the city should host the Winter Olympics in 2022. Mayor of Krakow Jacek Majchrowski during Mondays press conference. Photo: PAP/Stanislaw Rozpedzik. Jacek Majchrowski declared at a press conference that he i
In the 1980s scientists discovered that, despite microbes invisibility to us, the microbial world is as, or more, diverse than the macroscopic world of plants and animals. Traditional measures of diversity relied on physical traits, but such criteria can not be used to assess relationships between microorganisms and macroorganisms because there are so few physical traits common to both. In the 1980s Carl Woese suggested that the deoxyribonucleic acid (DNA) sequences of certain common genes could be used to measure relatedness among radically different organisms. He picked the genes that encode ribosomal RNA (rRNA). Ribosomes, the protein-RNA complexes that are the scaffold on which proteins are synthesized, are common to all cells, both prokaryotic and eukaryotic. Despite differences in size, the sequences of rRNA molecules contain regions that are highly conserved, thus highly similar. Woese chose the intermediate sized rRNA molecule, 16S rRNA in prokaryotes and 18S rRNA in eukaryotes because ...
Scientists have discovered that the deadly Ebola virus is an escape artist of the microbial world, physically breaking out of cellular prisons set up by the human body to further wreak havoc.
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In northern Alberta, mining operations to obtain bitumen from the oil sands generates large volumes of tailings. These are a mixture of sand, clay, water, organic solvents and residual bitumen that are deposited into old open pits, creating tailings ponds, where they are allowed to settle with the final goal of land reclamation. To speed up the sedimentation process, the addition of gypsum (CaSO4 ∙ 2H2O) is currently a management approach used bysome companies. This creates a deep watery mud line with very low oxygen permeability and enough sulfate to support the growth of anaerobic microbial communities. In this thesis work, the microbial physiology and communities associated with oil sands tailings ponds were assessed. Chemical, physiological, and molecular biology approaches were used to determine the key microbial processes (methanogenesis, sulfate reduction/oxidation), identify key substrates, and determine the dominant microbial community members in the anaerobic and aerobic zones of ...
Implementation of uranium bioremediation requires methods for monitoring the membership and activities of the subsurface microbial communities that are responsible for reduction of soluble U(VI) to insoluble U(IV). Here, we report a proteomics-based approach for simultaneously documenting the strain membership and microbial physiology of the dominant Geobacter community members during in situ acetate amendment of the U-contaminated Rifle, CO, aquifer. Three planktonic Geobacter-dominated samples were obtained from two wells down-gradient of acetate addition. Over 2,500 proteins from each of these samples were identified by matching liquid chromatography-tandem mass spectrometry spectra to peptides predicted from seven isolate Geobacter genomes. Genome-specific peptides indicate early proliferation of multiple M21 and Geobacter bemidjiensis-like strains and later possible emergence of M21 and G. bemidjiensis-like strains more closely related to Geobacter lovleyi. Throughout biostimulation, the ...
Project Instructions This collection contains records from Krakow, including questionnaires of Jews who applied for personal ID cards, household member lists, indexes, resettlement cards, and residence requests. The German army occupied Krakow in the first week of September 1939. In May 1940 the Germans began to expel Jews from Krakow to the neighboring countryside and required them to report for forced labor by October 1940. By March 1941, the SS and police had expelled more than 55,000 Jews, and about 15,000 Jews remained in Krakow. In early March 1941, German officials ordered the establishment of a ghetto located in the south of Krakow. Between 15,000 and 20,000 Jews lived within the ghetto boundaries. The SS and police liquidated the Krakow ghetto on March 13-14, 1943, fulfilling Himmlers order in October 1942 to complete the murder of Jews residing in the Generalgouvernement, incarcerating those whose labor was still required in forced-labor camps. The records are primarily in German. ...
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Cristal Zuñiga, Chien-Ting Li, Tyler Huelsman, Jennifer Levering, Daniel C. Zielinski, Brian O. McConnell, Christopher P. Long, Eric P. Knoshaug, Michael T Guarnieri, Maciek R. Antoniewicz, Michael J. Betenbaugh and Karsten Zengler ...
Two completely new sections have been added to Part 1: bacterial communities and human bacteriology. The bacterial communities section reflects the growing realization that studies on pure cultures of bacteria have led to an incomplete picture of the microbial world for two fundamental reasons: the vast majority of bacteria in soil, water and associated with biological tissues are currently not culturable, and that an understanding of microbial ecology requires knowledge on how different bacterial species interact with each other in their natural environment. The new section on human microbiology deals with bacteria associated with healthy humans and bacterial pathogenesis. Each of the major human diseases caused by bacteria is reviewed, from identifying the pathogens by classical clinical and non-culturing techniques to the biochemical mechanisms of the disease process ...
Recent publications have proposed that aging should be classified as a disease. The goal of this manuscript is not to dispute these claims, but rather to suggest that when classifying aging as a disease, it is important to include the contribution of microbes. As recently as ~115 years ago, more than half of all deaths were caused by infectious diseases. Since then, the establishment of public health departments that focused on improved sanitation and hygiene, and the introduction of antibiotics and vaccines allowed for a dramatic decrease in infectious disease-related mortality. In 2010, the death rate for infectious diseases was reduced to 3%. Simultaneously, as infectious disease-related mortality rates have decreased, global life expectancy has increased from ~30 to ~70 years. Because death rates due to infectious diseases have been reduced to very low levels, weve forgotten about the adverse effects of microbes on our existence. The fact is, we live in a microbial world. Even at a young ...
The bacteria causing diseases that are now becoming serious public health threats are neither strange nor exotic, but rather shockingly familiar. Tuberculosis, typhoid fever, meningitis, pneumonia, and septicemias are emerging global threats. The infectious agents causing these serious threats are the same bacteria identified many decades ago. The only difference is that these and other microorganisms are no longer killed by the miracle drugs that have kept them at bay for the past six decades. Antibiotic resistance has made potential killers out of bacteria that previously posed little threat to mankind. The indiscriminate and reckless use of antibiotics has led to a fast-appraoching crisis in which human dominance of the planet is threatened by single, elementary cells of the microbial world. Part I of this article detailed the causes of the crisis. Part II addresses the solutions that are recommended by national and international authorities and organizations ...
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In a recent blog post at theEGG me and Philipp Altrock argued for caution when applying game theoretic models to cancer. One of our concerns was the difficulty of measuring selective advantage, which is not constant, but changes with the frequency of the genotype. This problem has been partially addressed in a new paper by Ribeck & Lenski. I have one reservation though: they only consider frequency dependence in one of two competing clones, which means that their approach cannot be applied to a general two-player game which has two free parameters. Also as a mathematician I would like to see a more rigorous comparison between the Monod model for cross-feeding and the proposed model for frequency dependence, but this paper is at least showing us the way forward ...
I would like to make one comment about some of the posts on here about the gastric bypass fighting Roux-En-Y Some of you dont have a clue.. You really dont. You think everyone that has that surgery either has cancer or are just a lard-ass trying to take the easy way out so they can pig down more food... I had this very surgery.. Only because I was a diabetic and had the damn nerves damaged in my legs from the sugar.. At that time I only weighed 215 lbs. It got to a point where I couldnt hardly walk from the nerve pains.. So the weight came on. After getting to around 325-350 lbs I wanted to do something about it before any serious health issues came up. I had the bypass surgery and it was the biggest mistake in my life and I am just 49 y/o. I had the surgery march/2013, in the first year I never could hold food down because the food never made it into my stomach.. So the first 3 months all I could eat was pudding and yogurt.. Anything soft that I knew could pass into the stomach with low ...
3 images. Whale skeleton (City of Long Beach Museum at Colorado Lagoon, Long Beach), 19 February 1954. Whale drifted dead on strand in 1897; Ross McKee; Joe Rahl; Dick Glasco; Dr. M. Dale Arvey (Assistant Professor of Zoology, Long Beach State College); Claude McFaddin (City Recreation Department).; Caption slip reads: "Photographer: Emery. Date: 1954-02-19. Reporter: Emery to rw. Assignment: Whale skeleton (City of Long Beach museum piece, at Colorado Lagoon, Long Beach). 41: Zoologist and city recreatn [sic] dpt. crewmen tackle job of renovating ancient skeleton of 60-ton whale, a prized trophy owned by City of Long Beach since whale drifted dead on strand there May 20, 1897. Group of three at left background, l to r: Ross McKee, Joe Rahl, Dick Glasco. Group of two, foreground, l to r: Dr. M. Dale Arvey, asst. prof. of zoology at Long Beach State College; Claude McFaddin of city recreation dpt. 70: Dr. Arvey (with humerus bone of whale); beyond him is McFaddin. 30: l to r: McFaddin & Dr. Arvey ...
Description of Research Interests. Molecular detection and characterization of foodborne bacterial pathogens; epidemiological typing, bacterial stress response, microbial physiology and pathogenicity and control of pathogens and their toxins in food.. Selected Recent Publications. Chen, J., Lazar, N. (2012). Selection of working correlation structure in generalized estimating equations via empirical likelihood. Journal of Computational and Graphical Statistics, 21, 18-41.. Yoo, B. K., Chen, J. (2009). Influence of culture conditions and medium composition on the production of cellulose by the cells of Shiga toxin-producing Escherichia coli. Applied and Environmental Microbiology, 75, 4630-4632.. Nagachinta, S., Chen, J. (2009). Integron-mediated antibiotic resistance in Shiga toxin-producing Escherichia coli. Journal of Food Protection, 72, 21-27.. ...
The green microalgae Chlorella vulgaris has been widely recognized as a promising candidate for biofuel production due to its ability to store high lipid content and its natural metabolic versatility. Compartmentalized genome-scale metabolic models constructed from genome sequences enable quantitative insight into the transport and metabolism of compounds within a target organism. These metabolic models have long been utilized to generate optimized design strategies for an improved production process. Here, we describe the reconstruction, validation, and application of a genome-scale metabolic model for C. vulgaris UTEX 395, iCZ843. The reconstruction represents the most comprehensive model for any eukaryotic photosynthetic organism to date, based on the genome size and number of genes in the reconstruction. The highly curated model accurately predicts phenotypes under photoautotrophic, heterotrophic, and mixotrophic conditions. The model was validated against experimental data and lays the ...
Kraków (also spelled Cracow), the former capital of Poland, is located 180 miles south of the present capital of Warsaw. It is one of Polands largest (pop. 780,000), most historic and most beautiful cities.. In addition to its rich medieval history centering around Polish royalty, Krakow was home to two famous 20th-century personages: Oskar Schindler of Schlinders List fame and the future Pope John Paul II, who lived here for 40 years as a priest and later as Archbishop of Krakow. One of few Polish cities to escape major devastation by the Nazis during World War II, todays Krakow is renowned for its beauty by Poles (it is the most popular domestic tourist destination) and foreigners alike. It has become an essential stop on the main Central European tourism axis that includes Vienna, Budapest, and Prague. UNESCO designated the city a World Heritage Site in 1978 for its many historic buildings, which include numerous old churches full of religious art and no less than seven historic ...
incollection{2087361, abstract = {Metabolism can be defined as the complete set of chemical reactions that occur in living organisms in order to maintain life. Enzymes are the main players in this process as they are responsible for catalyzing the chemical reactions. The enzyme--reaction relationships can be used for the reconstruction of a network of reactions, which leads to a metabolic model of metabolism. A genome-scale metabolic network of chemical reactions that take place inside a living organism is primarily reconstructed from the information that is present in its genome and the literature and involves steps such as functional annotation of the genome, identification of the associated reactions and determination of their stoichiometry, assignment of localization, determination of the biomass composition, estimation of energy requirements, and definition of model constraints. This information can be integrated into a stoichiometric model of metabolism that can be used for detailed ...
Product Description: Revolutionary research is revealing how the trillions of microbes living on and in our bodies can keep us healthy . . . or make us sick Suddenly, research findings require a paradigm shift in our view of the microbial world. The Human Microbiome Project at the National Institutes of Health is well under way, and unprecedented scientific technology now allows the censusing of trillions of microbes inside and on our bodies as well as in the places where we live, work, and play...read more ...
This is the new home for ASMs Image Gallery, Laboratory Protocols, Curriculum Archive, and Visual Media Briefs, which were previously available at MicrobeLibrary.org. All collections feature free, original, open-access content submitted and peer-reviewed by members of the microbiology educator community. The mission of the Resource Library is to promote good pedagogy in microbiology, foster scholarly teaching, and enhance understanding about the microbial world.. Click the bold links below to navigate to each of the collections, and be sure to read the information about permitted reuse and citations if you plan to use these resources in your classroom. The Resource Library is not accepting new submissions at this time, but stay tuned for additional information. ...
A team of gynaecologists from Krakow have developed a 3D model of the foetal heart thanks to which it will be easier to diagnose the 29 most common heart defects in the womb.
Quito is the capital of Ecuador. It was founded in 1534 on the ruins of an ancient Inca city. Today, two million people live in Quito. It was the first city to be named a UNESCO World Heritage Site [http://whc.unesco.org/en/list/2 in 1978 (along with Krakow in Poland).
Quito is the capital of Ecuador. It was founded in 1534 on the ruins of an ancient Inca city. Today, two million people live in Quito. It was the first city to be named a UNESCO World Heritage Site [http://whc.unesco.org/en/list/2 in 1978 (along with Krakow in Poland).
He completed his Master of Sciences (M.Sc.) from Jagiellonian University, Krakow, Poland and Doctor of Sciences (D.Sc.) from the same university as well. His Doctor of..
Hi. Im newly diagnosed (3 weeks ago!) and an American living in Krakow, Poland (my husbands job brought us here.) I have my doubts about other Krakovians ...
Roitts Essential Immunology - the textbook of choice for students and instructors of immunology worldwide Roitts Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines.. The 13th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those ...
The worlds leading clinical conference on bone, joint and muscle health will take place in Krakow, Poland.. WCO, IOF and ESCEO have worked in partnership for several years to develop a unique European springtime meeting programme for healthcare professionals, researchers and young scientists.. We are eagerly looking forward to welcoming you in Krakow from April 19 to April 22, 2018.. Congress Chairpersons:. Jean-Yves Reginster (ESCEO President) and John A. Kanis (IOF President). Scientific Committee Chairpersons:. Cyrus Cooper (Chair, IOF Scientific Committee) and René Rizzoli (Chair, ESCEO Scientific Committee). ...
Hydrologic exchange plays a critical role in biogeochemical cycling within the hyporheic zone (the interface between river water and groundwater) of riverine ecosystems. Such exchange may set limits on the rates of microbial metabolism and impose deterministic selection on microbial communities that adapt to dynamically changing dissolved organic carbon (DOC) sources. This study examined the response of attached microbial communities (in situ colonized sand packs) from groundwater, hyporheic, and riverbed habitats within the Columbia River hyporheic corridor to "cross-feeding" with either groundwater, river water, or DOC-free artificial fluids. Our working hypothesis was that deterministic selection during in situ colonization would dictate the response to cross-feeding, with communities displaying maximal biomass and respiration when supplied with their native fluid source. In contrast to expectations, the major observation was that the riverbed colonized sand had much higher biomass and ...
The Holobiont is the overall plant biochemistry that involves plant kingdom along with microbial world of bacteria and viruses interactive with plant world. The microbiome is the large Holobiont that...
Get ready - the natural wine phenomenon is about to hit Poland.. Natural wine? It means wine made with grapes, and nothing else. The natural wine credo is absolutely no chemical intervention and minimal technological intervention in growing grapes and making them into the good stuff.. On June 16, Krakow will welcome a legend of the natural wine world, Frank Cornelissen, and some of the most interesting and sought after natural wines to reach the Polish market.. Frank is a Belgian-born winemaker whose search for the perfect terroir led him to the active volcano of Mt. Etna on the island of Sicily about 14 years ago.. A fervent non-interventionist, Frank says his winemaking avoids: "all possible interventions on the land we cultivate, including any treatments, whether chemical, organic, or biodynamic - all these are a reflection of the inability of man to accept nature as she is and will be.". In the EU, a bottle of wine can contain more than 100 additional ingredients before it is sent to the ...
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Szymon Leyb GLETNER 1779 - 1828 #272 + Rozli BISAM 1793-97 - 1834 #210 3o Ettel GLETNER 1818 #126 3x Oyzer GLETNER 1820 #46 - 1821 #143 3x Kalman GLETNER 1823 #215 - 1825 #72 3o Ryfka GLETNER 1826 #101 - after 1890 * Herschel ERBER Mar 16, 1824 #113 - after 1890 married Jul 28, 1887 #99 FAMILY LISTING 3o Sime GLETNER 1829 #216 * Abraham FLENDER 1822 4o Marya Reizel FLENDER Feb 10, 1860 Krakow * Salomon FENDLER Apr 9, 1856 #235 married Aug 26, 1886 #79 FAMILY LISTING 4x Elias Moritz (Mojzesz) FLENDER Mar 2, 1862 Krakow - 1911 Krakow + Mariem KEMPLER Jul 14, 1862 Lapanow pt. Bochnia - 1910 Krakow 5o Anna FLENDER 5o Regina FLENDER 5x Abraham FLENDER Oct 21, 1881 #610 - 1951 NY + Ester (Emma) STURZ Jan 22, 1887 #41 - Sep 21, 1936 #8835 Bronx NY married Jan 22, 1911 Bronx NY 6x Murray E FLENDER Nov 4, 1911 Bronx NY - Jan 11, 2004 Hurley NY + Mildred GOLDMAN Mar 19, 1916 NYC - Nov 19, 2008 Hurley NY married Sep 2, 1937 #7335 Bronx NY 6x Stanley (Samuel J) FLENDER Jun 9, 1913 NY - Mar 15, 1996 Bergen ...
Dlugosz describes the begining of this shield, without description of the century, only mentions an ancestor Skuba, a very strong man; some say that during Grak reign, who just founded Krakow, Skuba prepared the cow skin putting poison, tar and sulphur into it so it looked like a live cow, and Dlugosz mentions Skuba because he was a shoemaker. About his descendants doesnt write any more except that they were great men, what looking at who this shield belongs to - you will better understand reading about ancestors and their descendants, who I can know in such large kingdom. Descendants of this Skuba, whom Dlugosz mentions, were Skarbkowie (eg. family of Skarbek) from Gora (de Gora) and from those the very first mentioned in the catalogue is: Michal, whose son Lampart was a Krakows bishop in 1083, who took this position after holy martyr Stanislaw from Krakow canonry; about him writes that he was "vir modestus, in scripturis sacris et humanis insigniter eruditus". He had been a bishop for 18 ...
A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
OMG this disinfectant kills HIV!!!!" is a statement that I have encountered on more than one occasion. Needless to say, each time Im presented with it I give a little chuckle. You see, for those of us with a rudimentary understanding of microbiology and more specifically how microorganisms interact with disinfectants, this is akin to stating that youre surprised or relieved that a 12 gauge shotgun will be effective at killing a pesky mosquito.As Nicole highlighted in her blog posting "Strength is NOT always found in numbers", there is a hierarchy in the microbial world with respect to the susceptibility of microbes to disinfection. HIV is but one of the numerous enveloped viruses that rank at the very bottom of this ladder. In other words, enveloped viruses - including HIV, Hepatitis B, Hepatitis C and Influenza A - are exceptionally easy to kill with disinfectants. In fact, not a single hospital grade disinfectant should have an issue in rapidly and effectively eradicating HIV and other ...
Publications. Hern ndez-Machado B., and Casillas, L. (2009). Design and Assessment of an Introductory Geomicrobiology Course for Non-Geology Majors. Journal of Geoscience Education. p.p. 23-32. PDF. Isenbarger, T.A., Finney, M.R os-Vel zquez, C. et al. (2008). Miniprimer PCR, a New Lens for Viewing the Microbial World. Applied and Environmental Microbiology. p.p. 840-849. PDF. R os-Vel zquez, C. et al. (2007). Learning Geomicrobiology as a Team Using Microbial Mats, a Multidisciplinary Approach. Journal of Microbiology & Biology Education. p.p. 28-35. PDF. Cantrell, S.A. et al. (2007). Periconia variicolor sp.nov., a new species from Puerto Rico. Mycologia, 99(3), pp. 482-487. PDF. Cantrell, S.A. et al. (2006). Characterization of fungi from hypersaline environments of solar salterns using morphological and molecular techniques. Micological Research 110. p. 962-970. PDF. Casillas-Martinez, L. et al. (2005). Community Structure, Geochemical Characteristics and Mineralogy of a Hypersaline ...
Plant-microbe associations are enormously diverse, ranging from parasitism through mutualism to symbiosis. Many of these interactions may have profound effects on the dynamics and structure of host communities. These effects may be induced through differential parasitic attack affecting some components of a community more than others; through an enhanced nitrogen economy resulting from the establishment of rhizobial -plant associations; through the establishment of endophytic mutualisms; or through complex mycorrhizal associations between host and fungus. The work in this project has the overall aim of understanding the processes leading to the development and maintenance of coevolutionary associations between plants and the microbial world. A primary motivation for our disease research is that a broad understanding of the ecological and evolutionary dynamics of host-pathogen interactions must take spatial structure into account. To that end, we are applying an integrative approach using both ...
We now understand the importance of building and sustaining a healthy human microbiome, but at the same time we increasingly understand the importance of hygiene in the community - not least as a means to reduce antibiotic prescribing. The question is then -"how do we best protect against infection whilst re establishing our connection with the microbial world we live in". The answer lies mainly in lifestyle changes e.g returning to natural childbirth, outdoor activity, less antibiotics, better diet - but also in "targeted hygiene". This means focussing on breaking the chain of infection by intervening in the places and at the time that matter - with an effective intervention. The key "places that matter" are our hands, hand contact and food contact surfaces - and cleaning cloths/sponges - these are the "superhighways" for spreading germs from infected sources which are mainly people, food and domestic animals. Cloths and sponges are critical control points - using a sponge to spread the ...
Bacteria face a constant threat of being infected and killed by viruses, called bacteriophages, that are specially equipped to destroy them. In the Bondy-Denomy lab we are interested in the ways in which bacteria defend themselves from attack. We use a combination of genetic, molecular and biochemical approaches to characterize the arms race between bacteria and phages, with a goal to better understand microbial ecosystems. Furthermore, we hope to make discoveries that will be influential in combatting infectious disease and providing novel biotechnologies.. The CRISPR-Cas system was functionally characterized just ten years ago as a bacterial immune system that targets phages. Since then, there has been an explosion of interest in this system for its widespread presence in the microbial world as well as its facile programmability. This has formed the basis of a revolutionary gene editing technique, CRISPR-Cas9. In the lab, we are focused on studying CRISPR-Cas systems in their natural settings, ...
ABSTRACT: BACKGROUND: Despite the availability of numerous complete genome sequences from E. coli strains, published genome-scale metabolic models exist only for two commensal E. coli strains. These models have proven useful for many applications, such as engineering strains for desired product formation, and we sought to explore how constructing and evaluating additional metabolic models for E. coli strains could enhance these efforts.$\backslash$n$\backslash$nRESULTS: We used the genomic information from 16 E. coli strains to generate an E. coli pangenome metabolic network by evaluating their collective 76,990 ORFs. Each of these ORFs was assigned to one of 17,647 ortholog groups including ORFs associated with reactions in the most recent metabolic model for E. coli K-12. For orthologous groups that contain an ORF already represented in the MG1655 model, the gene to protein to reaction associations represented in this model could then be easily propagated to other E. coli strain models. All ...
... is studying for her PhD in the field of Bioinformatics at Tel Aviv University. Her research focuses on the study of human disorders in which metabolism plays a central role, such as aging, cancer, and obesity. Keren develops novel computational methods to analyze cellular metabolism, by integrating high throughput data with genome-scale metabolic models. Her goal is to advance understanding of the pathogenesis of the underlying metabolic alterations of these diseases, and suggest novel therapeutic interventions to combat them. ...
For a long time microbial ecology has been developed as a distinct field with- in Ecology. In spite of the important role of microorganisms in the environ- ment, this group of invisible organisms re
A year and a half ago, Jesse Krakow organised a Captain Beefheart tribute concert as a benefit for Multiple Sclerose. The concert featured special guests Gary Lucas and Nona Hendryx ...
G. N Jurek completed his Graduated as a dentist from the Faculty of Dentistry, Jagiellonian University in Krakow in 1997. Obligatory postgrad..
From BioPortfolio: Krakow, Poland, August 6, 2015 / B3C newswire / -- Selvita, a global integrated drug discovery partner for the pharmaceutical and biotechnology industry, has be...
The bacteria on our skin, you can think of them as a protective barrier for pathogens," according to Dr. Mary Stromberger, associate professor of soil microbiology, in the department of soil and crop sciences. "Getting dirty is actually a good thing.". Humans could not live without bacteria and other microorganisms. They create our environment and keep us healthy.. "Over 90% of the cells in or on our body are bacterial cells," Stromberger said.. "We evolved into a microbial world," said Dr. Matthew Wallenstein, assistant professor in ecosystem science and sustainability. "Youd be hard pressed to find the smallest patch on earth that isnt coated with bacteria, even in the harshest environments.". According to Wallenstein, promoting biodiversity may be the best way we have to ensure that beneficial microbial communities are present, when you have ecosystems that are diverse communities it increases the chances of having microbes that can fight off the pathogens.. "Weve always been dealing with ...
August 6, 2007 to August 10, 2007. Each summer, NAIs Marine Biological Laboratory Team offers a one-week workshop for middle and high school teachers focusing on activities that can be incorporated into existing classroom curricula. Resident and visiting scientists from the Woods Hole community present teachers with background information and updates on current research developments on a variety of topics related to the importance of microbes and microbial processes in the biosphere.. Please follow Astrobiology on Twitter.. ...
The researchers examined cored samples of rock from 50 million years ago that included sections of "microbial mats.". "Microbial mats are essentially the microbial worlds version of apartment buildings - they are layered communities of microbes, and each layer represents a different metabolic strategy," Olcott-Marshall said. "Generally, the photosynthetic microbes are at the top, and then every successive layer makes use of the waste products of the level above. Thus, not only does a microbial mat contain a great deal of biology, but a great number of chemicals, pigments and metabolic products are made, which means lots of potential biosignatures." At times during the Eocene, the Green River Formations water chemistry purged fish and other organisms from the lake, providing room for these microbes to thrive.. "During these times, microbialites formed - these are rocks thought to be made by microbial processes, essentially the preserved remnants of microbial mats. The Green River Formation ...