How is Critical Micellular Concentration (concentration at which a detergent spontaneously forms micelles) abbreviated? CMC stands for Critical Micellular Concentration (concentration at which a detergent spontaneously forms micelles). CMC is defined as Critical Micellular Concentration (concentration at which a detergent spontaneously forms micelles) rarely.
HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS - diagram, schematic, and image 32 ...
Page contains details about PLA-PEO bottlebrush block copolymer micelles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Gohy, Jean-François ; Willet, N. ; Varshney, S. K. ; Jérôme, R.. Responsive block copolymer micelles.Rolduc 11th Polymer Meeting (Kerkrade (The Netherlands), du 05/05/2002 au 08/05/2002 ...
An endovascular stent comprising an expandable framework including a plurality of interconnected segments, and a plurality of entangled cylindrical micelles disposed on the expandable framework. Each of the plurality of cylindrical micelles may be loaded with a therapeutic agent.
Polymeric micelles self-assembled from cholesterol-conjugated poly(ethylene glycol) (PEG) and anchored with transcriptional activator TAT peptide (TAT-PEG-b-Col) were fabricated for delivery of antibiotics across the blood-brain barrier (BBB). Ciprofloxacin, which demonstrated a high bactericidal effect, was efficiently loaded into the micelles by a membrane dialysis method. The ciprofloxacin-loaded micelles were characterized via dynamic light scattering and SEM. The micelles were spherical in nature, having an average diameter of smaller than 180 nm. Sustained release of ciprofloxacin was achieved over 6 h in phosphate-buffered saline (pH 7.4) at 37°C. Confocal laser scanning microscopy reveals that the uptake of Fluorescein 5-isothiocyanate (FITC)-loaded TAT-PEG-b-Col micelles by human astrocytes was much higher than that of free FITC. Animal studies proved that these micelles crossed the BBB and entered the brain. The TAT-conjugated micelles may be used to deliver antibiotics across the BBB ...
In this study we explore the preparation of core-crosslinked micelles of linear-dendritic methoxy-poly(ethylene glycol) (MPEG)-co-poly(ester-sulfide) (PES) polymers to improve the stability of such polymeric micelle systems against premature disintegration and drug release. A series of MPEG-PES copolymers were synthesised via stepwise reactions of acetylation and thiol-ene photoreaction. Surface tension measurement showed that the copolymers with ethenyl surface groups could self-associate in dilute aqueous solutions to form micelles. Crosslinking within the micelle cores in the presence of dithioerythritol (DTT) linker was initiated under UV radiation. The formation of core-crosslinked micelles was confirmed by HPLC in combination with charged aerosol detection (CAD). The copolymers were found to readily hydrolyse under acidic conditions due to the ester-containing dendrons. Drug solubilisation capacities of the micellar solutions were determined using griseofulvin as a poorly water-soluble ...
Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.
A novel theory for the structural behavior of surfactant micelles is expounded. The micelles are considered to be generally shaped as triaxial tablets with distinct thickness width and length, respectively, and may become spherical, spherocylindrical or disk-shaped in the special cases where two or more of the dimensions are equal. It is demonstrated that the average width and length of a tablet-shaped micelle with a fixed thickness is mainly determined by two constants, k1 and k2, related to the first and second order correction in curvature of the micellar end caps. The size of the micelles is found to be mainly determined by k1, whereas k2 influences the shape, i.e., the length-to-width ratio, of the micelles so that the micellar size increases with increasing k1 and the length-to-width ratio decreases with increasing k2. Hence, large positive values of k2 promote the formation of tablets rather than very long spherocylinders. An additional parameter related to the curvature of the straight ...
Page contains details about supramolecularly engineered amphiphilic macromolecule spherical micelles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
In general as far as I know customers who bought Bioderma Sebium H2O Micelle Solution 2X500ml or other products in the Internet also were interested in reviews, cheap & lowest prices in outlets and stores, shipping, gift ideas, city deals, sales, coupons online, new, holiday & daily deals, bargain, best buy products including special offers on Bioderma Sebium H2O Micelle Solution 2X500ml, best deals, discount coupons, top & hot deals, great offers, last minute deals and so on ...
The goals of this project are to fabricate, optimize and characterize a nano self-assembled micelle system for drug delivery of siRNA.
A micellar solution consists of a dispersion of micelles in a solvent (most usually water). Micelles consist of aggregated amphiphiles, and in a micellar solution these are in equilibrium with free, unaggregated amphiphiles. Micellar solutions form when the concentration of amphiphile exceeds the critical micellar concentration (CMC) or critical aggregation concentration - CAC, and persist until the amphiphile concentration becomes sufficiently high to form a lyotropic liquid crystal phase.[1][2][3][4] Although micelles are often depicted as being spherical, they can be cylindrical or oblate depending on the chemical structure of the amphiphile. Micellar solutions are isotropic phases. Micellar water has been used in France since 1913.[5] ...
The rapamycin analog, ridaforolimus, has demonstrated potent anti-proliferative effects in cancer treatment, and it currently is being evaluated in a range of clinical cancer studies. Ridaforolimus is an extremely lipophilic compound with limited aqueous solubility, which may benefit from formulation with polymeric micelles. Herein, we report the encapsulation of ridaforolimus in 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000) (DSPE-PEG2000) via a solvent extraction technique. Micelle loading greatly improved the solubility of ridaforolimus by approximately 40 times from 200 μg/mL to 8.9 mg/mL. The diameters of the drug-loaded micelles were 33 ± 15 nm indicating they are of appropriate size to accumulate within the tumor site via the enhanced permeability and retention (EPR) effect. The DSPE-PEG2000 micelle formulation was dosed intravenously to rats at 10 mg/kg and compared to a control of ridaforolimus in ethanol/PEG 400. The micelle significantly increased the
We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of the micellar structure and rapid release of CPT. CCL micelles were prepared via coprecipitation of disulfide-containing CPT-poly(tyrosine(alkynyl)-OCA) conjugate and monomethoxy poly(ethylene glycol)-b-poly(tyrosine(alkynyl)-OCA), followed by cross-linking of the micellar core via azide-alkyne click chemistry. CCL micelles exhibited excellent stability under physiological conditions, while they underwent rapid dissociation in reduction circumstance, resulting in burst release of CPT. These redox-responsive CCL micelles showed enhanced cytotoxicity against human breast cancer cells in vitro. Wang, Hua; Tang, Li; Tu, Chunlai; Song, Ziyuan; Yin, Qian; Yin, Lichen; Zhang, Zhonghai; Cheng, Jianjun
The determination of the critical micelle concentration (CMC) value of surfactants under different environmental conditions is important for a number of different biological and chemical processes. Because the CMC is not a constant value, shifting with different environmental conditions, it is important that a rapid, reliable and easy methodology be available to facilitate testing. This application note describes the rapid semi-automated determination of CMC values for surfactants in 384-well mi
Polymeric micelles, self-assemblies of block copolymers, are emerging as attractive drug delivery systems for hydrophobic photodynamic sensitizers. Recent advances in the formulation of photosensitizers for photodynamic therapy (PDT) with diblock copolymers are presented. This paper reviews the main characteristics of existing drug-loading micelles with diblock copolymers, including loading efficiency, particle size and morphology, stability, cellular uptake, subcellular distribution and therapeutic efficiency. The results indicate that diblock polymeric micelles are potentially useful for the delivery and release of hydrophobic photosensitizers in PDT. While significant progress has been achieved, many challenges remain in elucidating the detailed internalization mechanisms of the micelles and resulting mechanisms for enhanced photocytotoxicity. Some critical issues for diblock copolymers to deliver hydrophobic photosensitizers for PDT are highlighted ...
1G8C: Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.
Using a very popular and commonly used surfactant sodium dodecylbenzene sulfonate (SDBS, C18H29SO3Na) for a case study, we report a new method of monitoring different forms of surfactant molecules in aqueous solution and measuring their critical micelle concentration (CMC) by ultraviolet-visible (UV-Vis) spectroscopy. The forms of SDBS micelles are also investigated by synthesizing and characterizing NiB nanoparticles using the micelles as molecular templates. In addition, the observed shifts of UV-Vis bands are analysed from the viewpoint of the electrons locations and distributions within the molecules and the possible overlap of their electronic orbitals between neighbouring molecules in each micelle ...
Polymeric nanoparticles formed by triblock copolymer polystyrene-block-poly(2-vinylpyridine)-block-poly(ethylene oxide), PS-PVP-PEO, in aqueous media were studied by a combination of fluorescence correlation spectroscopy with other fluorescence techniques, light scattering and atomic force microscopy. The studied polymeric nanoparticles exist in the form of (i) core/shell micelles in acid solution at pH lower than 4.8 and (ii) three-layer onion micelles at higher pH. Since water is a very strong precipitant for PS, both types of micelles have kinetically frozen spherical PS cores. The cores of micelles in acid media are surrounded by soluble shells formed by partly protonated PVP and PEO, while the cores of micelles in alkaline media are surrounded by compact insoluble layers of deprotonated PVP and soluble PEO shells. The micellization behavior of PS-PVP-PEO micelles is accompanied by secondary aggregation of micelles, which is provoked by stirring, shaking and also by filtration of micellar ...
The Krafft temperature (also known as Krafft point, or critical micelle temperature) is the minimum temperature at which surfactants form micelles. It is named after German chemist Friedrich Krafft. Below the Krafft temperature, there is no value for the critical micelle concentration (CMC), i.e., micelles cannot form. The Krafft temperature is a point of phase change below which the surfactant remains in crystalline form, even in aqueous solution. Visually the effect of going below the Krafft point is similar to that of going above the cloud point, with the solution becoming cloudy or opaque due to the surfactant molecules undergoing flocculation. Surfactants in such a crystalline state will only solubilize and form micelles if another surfactant assists it in overcoming the forces that keep it crystallized, or if the temperature increases, thus causing entropy to have a stronger force and encouraging the crystalline structure to break apart. Surfactants are usually composed of a hydrocarbon ...
DNA-based vaccines offer significant therapeutic potential but safe, efficacious delivery systems are still needed to enable clinical applications. Well-defined nonviral vectors, including those produced via reversible addition-fragmentation chain transfer (RAFT) polymerization, represent one approach for overcoming barriers to DNA delivery. Block copolymer micelles are an example of a complex architecture achievable by the RAFT process, adopting a core-shell morphology under physiological conditions. These polymeric nanoparticles consist of discrete segments capable of specific physicochemical and biological activities determined by their chemical composition. This thesis describes synthetic approaches focused on engineering the intra- and extracellular activity of this class of nanomaterials, with the goal of developing an in vivo DNA delivery platform. Chapter 1 focuses on how polymerization and carbohydrate chemistry techniques can be utilized to develop DNA-based cancer vaccines. Chapter 2 ...
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Polymeric micelles prepared from a series of poly(ethylene glycol)-poly(lactide) (PEG-PLA) diblock copolymers with various PLA chain lengths were designed as drug carriers for water insoluble drug amphotericin B (AmB). Physicochemical properties of AmB-loaded micelles were evaluated. Micelles were freeze-dried to obtain longtime stable formulations. The redispersibility of the freeze-dried samples was poor when the weight ratio of PLA block was bigger than the PEG block of the copolymer. Various types of lyoprotectants including saccharides and PEGs with different molecular weight were tested to improve the redispersion performance of the freeze-dried samples. PEG was proved to be more effective than saccharides on stabilizing the micelles during lyophilization when the weight ratio of PLA block was bigger than PEG block. The sustained release in vitro of AmB was evidenced. About 80% of AmB was released in 80 h. The in vitro release behavior could be best described by the first-order equation. ...
Since their discovery over a century ago, surfactant micelles have been a topic of intense interest in both academic and technological research [1]. Surfactant molecules consist of a hydrophilic head group covalently linked to a hydrophobic tail (hydrocarbon) group. In aqueous solution above a critical micellar concentration (cmc), they self-assemble into micelles consisting of a hydrophobic core of tail groups surrounded by a shell of hydrophilic head groups and water. The shape and size of these micelles depend on the type of surfactant and thermodynamic conditions such as temperature, solvent composition and salinity. Typically surfactant micelles aggregate into highly dynamic nanostructures consisting of either spherical or non-spherical shapes such as ellipsoidal, cylindrical and discoidal shapes. Detailed insight into their fundamental behaviour is important owing to their widespread applications ranging from detergents and additives in personal care and household cleaning products to ...
Senile plaques are well-known hallmarks of Alzheimers Diseases (AD). However, drugs targeting tangles of the protein tau and plaques of beta-amyloid have no significant effect on disease progression, and the studies on the underlying mechanism of AD remain in high demand. Growing evidence supports the protective role of senile plaques in local inflammation driven by S100A9. We herein demonstrate that oleic acid (OA) micelles interact with hen egg white lysozyme (HEWL) and promote its amyloid formation. Consequently, SH-SY5Y cell line and mouse neural stem cells are rescued from OA toxicity by co-aggregation of OA and HEWL. Using atomic force microscopy in combination with fluorescence microscopy, we revealed that HEWL forms round-shaped aggregates in the presence of OA micelles instead of protofibrils of HEWL alone. These HEWL amyloids act as a sink for toxic OA micelles and their co-aggregate form large clumps, suggesting a protective function in amyloid and OA cytotoxicity.. ...
Environmentally responsive nanoparticles synthesized from Elastin-Like Polypeptides (ELP) present a promising system for applications such as biosensors, drug delivery vehicles, and viscosity modifiers. These nanoparticles undergo a transition from a soluble state at Troom to micellar aggregates above the transition. The ELP micelles have been found to be sensitive to various outside stimuli including pH, salt concentration, and solvent. Dynamic and Static Light Scattering were used to study structure and dynamics of ELP nanoparticles below the transition and of formed ELP micelles above the transition. Micelles were found to generally depend strongly on solution pH, however, in the pH window of 10.1-10.4 their size stayed constant. The apparent radius and molecular weight of micelles in this pH range strongly depend on salt concentration with three apparent regimes. At low salt (0-15mM), largely spherical micelles were found with Rh=15nm, which corresponds to the size of folded ELP hydrophilic tail;
Water-based cleansers are all the rage right now. As more beauty bloggers started talking about them, the more I felt intrigued to try one out for myself. Its safe to say Im I glad I did. Ive been using Bioderma Sensibio H2O Micelle Solution for just over a month now, and Im happy to say that this is the best cleanser I have ever used. It retails for £9.99 for 250ml or £4.50 for 100ml at www.escentual.com. The formulation is specifically designed for people with normal-to-dry and sensitive skin. I have particularly sensitive areas in my cheeks and chin, and it doesnt irritate them at all. Its also fragrance free which is great for me as I avoid putting fragranced products on my face at all costs. I apply to my whole face, neck and eyes in upwards motions. Not only does it remove make-up, it also removes dirt and other nastiness from your face. Its amazing seeing the amount of stuff that comes off your face on the cotton pad. I use twice daily, morning and night, as the first step in my ...
Get even more gentle and efficient cleansing for your sensitive skin with the Bioderma Sensibio H2O Micelle Solution 500ml, the original ultra-mild, non rinse water cleanser. The bestselling water is now available in a large 500ml size, and com
Guarantee gentle cleansing with the Bioderma ABCDerm H2O Micelle Solution, a delicate micellar water that respects the balance of all skin, even the most fragile. Created with the delicate skin of babies and children in mind, the ABCDerm H2O Mi
Bioderma Sensibio H2O micelární voda pro citlivou pleť (Micelle Solution) 500 ml z kategorie Pleť značky Bioderma koupíte na Parfums.cz
Supramolecular assemblies involving interaction of a small organic molecule, 2-hydroxy-6-Naphthoic acid (HNA), with poly(styrene)-block-poly(4-vinylpyridine) (PS-b-P4VP) diblock copolymers are utilized to obtain micellar structures in solution, nanostructured thin films on flat substrates and, finally, nanoporous thin films. The formation of hydrogen bonds between HNA and the poly(4-vinylpyridine) (P4VP) blocks is confirmed by spectroscopic measurements. The accordingly P4VP/HNA hydrogen-bonded complexes are poorly soluble in 1,4-dioxane, resulting in the formation of micellar structures with a P4VP/HNA core and a polystyrene (PS) corona. Those micelles have been spin-coated onto silicon wafers, resulting in nanostructured thin films consisting of P4VP/HNA dot-like features embedded in a PS matrix. The morphology of those films has been tuned by solvent annealing. Selective dissolution of HNA by methanol results in the formation of a nanoporous thin film. The P4VP/HNA nanodomains have been also
35 into Eq. 36, and rearranging leads to Çw Çw dNT 71 = kemms [R*w] = 7788 = 77241 dt 1 + (kep NT /kemms ) 1 + (eNT /Sm) (37) where kepNT/kemms denotes the ratio of the rate of radical entry into polymer particles to that into micelles and is rewritten as eNT/Sm, where e=(kep/kem)Mm and e is the one unknown parameter, which affects the number of polymer particles produced. Here, Sm is the total number of emulsifier molecules forming micelles, and Mm is the aggregation number of emulsifier molecules per micelle, defined by Mm=Sm/ms. Case A: The rate of radical entry into micelles that results in the formation of new particles is approximately equal to the rate of radical generation in the water phase (Çw), as long as emulsifier micelles are present; in other words, dNT 7 = Çw dt (28) Particle formation stops at the time tc, when the emulsifier micelles have just disappeared because all of the emulsifier molecules comprising the emulsifier micelles have been transferred to the surfaces of ...
Current research has shown that polymers themselves are bioactive - they actively coordinate with binding domains on low density lipoproteins. In addition, the polymeric micelles can be slightly modified for complexation with oligonucleotides and plasmids. Second, PolymerDrugs are polymers that biodegrade into therapeutically useful molecules.
TY - JOUR. T1 - Micellization in aqueous solutions of monoalkyl phosphate salts. AU - Arakawa, Jun. AU - Pethica, Brian Anthony. PY - 1980/1/1. Y1 - 1980/1/1. N2 - The micellization of the mono-salts of octyl, decyl, and dodecyl phosphates and of the di-salts of dodecyl phosphate have been studied in aqueous solutions by conductivity methods. The effects of temperature, salt concentration, counterion type, and chain length have been examined. The mono-salts of the alkyl phosphates show properties similar to those of fatty acid soaps and alkyl sulfates. The di-salts show rather different counterion and temperature effects. The solubility diagrams for the mono-salts are anomalous and are explained in terms of the preferred precipitation of stable solid salts of the composition RPO4H2-RPO4HM where M is an alkali metal.. AB - The micellization of the mono-salts of octyl, decyl, and dodecyl phosphates and of the di-salts of dodecyl phosphate have been studied in aqueous solutions by conductivity ...
Angewandte Chemie Channels in Micelles DOI: 10.1002/ange.200600172 Formation of Complex Micelles with DoubleResponsive Channels from Self-Assembly of Two Diblock Copolymers** Guiying Li, Linqi Shi,* Rujiang Ma, Yingli An, and Nan Huang The establishment of an effective method to prepare desirable nanostructures and to eventually convert them into designed architectures is of increasing interest in nanotechnology, chemistry, and biology. Proteins that are located in the phospholipid bilayer of cell membranes are important in forming transient pores or channels to achieve ion transport, ion regulation, energy transduction, signal recognition, and other biological processes. Numerous functional materials, including nanoporous membranes and synthetic transmembrane channels, have been designed based on these important gating structures in order to mimic biological processes.[1-4] It is now well established that amphiphilic block copolymers can self-assemble into lipid-like membranes with tunable ...
We have a significant interest in the role that these colloidal dispersions can play in mediating solvent properties for enhancing separation and reaction processes in the chemical, metallurgical and biochemical industries. A major thrust of our research program, thus, is to explore novel techniques to optimize solvents for specific applications, and to characterize them in terms of the fundamental molecular processes responsible for the solvation properties of the structured solvents. The primary emphasis is on colloidal surfactant and polymer aggregates such as micelles and reversed micelles which provide a nonisotropic, microstructured environment for the selective interaction with targeted solutes in an otherwise homogeneous macrophase. We have, for instance, used reversed micelles to solubilize polar solutes such as proteins and amino acids in organic solvent extractants, block copolymer micelles for the removal of trace contaminants from surface and groundwaters, and two-phase aqueous ...
Cholesterol esterase, also secreted from the pancreas, hydrolyses cholesterol-fatty acid esters into cholesterol and free fatty acids. Short-chain fatty acids and free glycerol are then absorbed directly into the mucosa of the small intestine and transported to the portal circulation. Other free fatty acids, monoglycerides and cholesterol molecules are emulsified by bile salts, forming micelles which are essential for normal fat absorption. Water-insoluble compounds such as polar unsaturated fatty acids and monoglycerides that cannot form micelles alone readily form stable mixed micelles with conjugated bile salts. Saturated fatty acids such as palmitic and stearic acids on the other hand, which are non-polar and that have high melting points are only slightly soluble in emulsions with bile salts. They are, however, markedly solubilized in the presence of a mixed micelle.. In this form, the fatty acids and other lipid-like materials are solubilized in the aqueous phase of the lumen and are ...
Yeah, this is an idea that seems to get glossed over some of the time. It seems the natural tendency of molecules with hydrophilic heads / hydrophobic tails is to form micelles, because this is the simplest structure that maximizes hydrophobic/philic interaction. In phospholipids, however, the hydrophobic tails have a greater cross-sectional area than the heads, and so they cannot form stable micelles - in other words, the volume of the interior of a hypothetical phospholipid micelle would not allow the hydrophilic heads to make a continuous, unbroken surface. The simplest way for phospholipids to hide their hydrophobic tails is the lipid bilayer configuration. Hopefully that helps anyone who stumbles across this board in the future ...
TY - JOUR. T1 - Assembly of polyelectrolyte-containing block copolymers in aqueous media. AU - Cohen Stuart, Martien A.. AU - Hofs, Bas. AU - Voets, Ilja K.. AU - de Keizer, Arie. PY - 2005/8/1. Y1 - 2005/8/1. N2 - In this review we present an overview of the developments of (self-)assembly of linear block copolymers containing one or more polyelectrolyte blocks in aqueous solution. Different micellar structures and phase behaviour are described. The role of inter- and intramolecular complex coacervation is emphasised. Recent developments in applications of assembly of polyelectrolyte-containing copolymers are presented.. AB - In this review we present an overview of the developments of (self-)assembly of linear block copolymers containing one or more polyelectrolyte blocks in aqueous solution. Different micellar structures and phase behaviour are described. The role of inter- and intramolecular complex coacervation is emphasised. Recent developments in applications of assembly of ...
One might put water into a bucket, throw a little detergent into the water, and then throw a dirty, greasy shirt in the bucket. The shirt is agitated in the water/detergent mixture, rinsed, and finally, a sparkling clean shirt is pulled out of the mix. Where did the oil go? The oil interacts with the detergents to form micelles. As shown above, detergents have a structure that is similar to the structure of the phospholipids that are a part of the plasma membrane, but typically, the detergent has only one fatty acid tail. In this scenario, the hydrophobic portion will face the interior of the micelle. Hydrophobic particles, such as skin oil, could also be carried inside the micelle as cargo molecules. That is what happens in the washing machine. The same principle is used for certain types of drug delivery. Hydrophobic drugs are often delivered using surfactants to form micelles, with the drugs being carried as cargo. Hydrophilic head groups will make up the exterior of the micelle, making it ...
PolySciTech (www.polyscitech.com) Polymer University: Micelles 103 Movie now posted. Fun and educational look at solubility problems in medicine as well
1NG8: The Structure, Cation Binding, Transport and Conductance of Gly15-Gramicidin a Incorporated Into Sds Micelles and Pc/Pg Vesicles
This Thesis presents studies of molecular association in aqueous solution and at the liquid/solid interface. The investigated molecular systems range from self-aggregating surfactants to hydration water in contact with micelles or individual molecules. In most studies, combinations of various NMR methods were applied. These vary from simple chemical shift and intensity measurements to more elaborate self-diffusion and intermolecular cross-relaxation experiments.. Non-ideal mixed micelles of fluorinated and hydrogenated surfactants were studied by an experimental procedure that allows an analysis in terms of micellar structure, using a minimal number of initial assumptions. Quantitative conclusions about micro-phase separation within mixed micelles were obtained within the framework of the regular solution theory. Additionally, NMR was introduced and developed as a powerful method for studying adsorption of surfactants at solid interfaces. Adsorption isotherms for pure and mixed surfactant ...
TY - JOUR. T1 - Computer Simulation of Luminophore Solubilization in Reverse Micelles. AU - Kopanichuk, I. V.. AU - Vanin, A. A.. AU - Ostras, A.. AU - Brodskaya, E. N.. PY - 2018/5/1. Y1 - 2018/5/1. N2 - The solubilization of ionic (sodium naphthalene-2,6-disulfonate) and nonionic (diethyl 2,5-dihydroxyterephthalate) organic luminophores in water-isooctane-Na (sodium 1,4-bis[(2-ethylhexyl) oxy]-1,4-dioxybutane-2-sulfonate) reverse micelles is simulated by the molecular dynamics method. In a stationary state, the localization of luminophore molecules in a micelle appears to be the same irrespective of their initial positions in the system. The position and orientation of solubilized luminophores relative to a reverse micelle depend on the hydrophobicity and the capability for dissociation of the functional groups of their molecules, the size of the reverse micelle, and the structure of its electrical double layer.. AB - The solubilization of ionic (sodium naphthalene-2,6-disulfonate) and ...
Contrast variation SANS and F-19 chemical shifts were measured for three mixed equimolar micelle systems: sodium perfluorooctanoate (SPED) and sodiumdecylsulfate (SDeS) in 200 mM NaCl, lithium perlluorononanate LiPFN) and lithium dodecylsulfate (Li DS) in 200 mM LiCl, and a nonionic system C8F17C2H4(OC2H4)(9) and C12H25(OC2H4)(8) in water, all at 25 C. The chemical shift measurements allow the calculation of the average fraction of nearest neighbors of each kind around the reporter group (the trifluoromethyl group). A preference for like neighbors were found in all systems, smallest in the SDeS/SPFO system and largest in the nonionic system, but in all cases substantially smaller than expected at critical conditions. From the SANS measurements the width of the micelle composition distribution was obtained. For the ionic systems similar values were obtained, showing a broadening compared to ideal mixtures, but not broad enough for demixing or clearly bimodal distributions. In the nonionic system the
The purpose of blocking solution is to block exposed glass surfaces after binding anti-dig. Various kinds of casein are typically used, which I think evolves from the common practice of using non-fat dried milk (NFDM) in standard wet-lab protocols, such as western blotting. NFDM is predominantly casein, and so people use NFDM and casein interchangeably, usually ignoring the fact that differences in purity or kinds of casein could potentially impact a sensitive assay. Often it is imagined that casein is a regular soluble protein, but [[User:Steven J. Koch,Dr.Koch]] found in the past that casein forms polydisperse micelles, probably. He doesnt know whether these polydisperse micelles are important for its blocking capabilities, but he did find some references that said they are (small micelles fill gaps in big micelles). Brent Brower-Toland, being a good biologist, ignored the anlaysis paralysis of physicists and just ordered cheap good blocker from Bio-Rad, called Blotting-Grade Blocker ...
The purpose of blocking solution is to block exposed glass surfaces after binding anti-dig. Various kinds of casein are typically used, which I think evolves from the common practice of using non-fat dried milk (NFDM) in standard wet-lab protocols, such as western blotting. NFDM is predominantly casein, and so people use NFDM and casein interchangeably, usually ignoring the fact that differences in purity or kinds of casein could potentially impact a sensitive assay. Often it is imagined that casein is a regular soluble protein, but [[User:Steven J. Koch,Dr.Koch]] found in the past that casein forms polydisperse micelles, probably. He doesnt know whether these polydisperse micelles are important for its blocking capabilities, but he did find some references that said they are (small micelles fill gaps in big micelles). Brent Brower-Toland, being a good biologist, ignored the anlaysis paralysis of physicists and just ordered cheap good blocker from Bio-Rad, called Blotting-Grade Blocker ...
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Reactivity of organic compounds inside micelles embedded in sol-gel glass. Kinetics of summarization of azobenzene inside C/TAB and SDS micelles