BioAssay record AID 710427 submitted by ChEMBL: Binding affinity to TLR2 in human SU.86.86 cells xenografted in Harlan athymic nude mouse tumor assessed as increase in fluorescence at 100 nmol/kg, iv measured up to 24 hrs.
Peloruside A is a microtubule-stabilizing agent isolated from a New Zealand marine sponge. Peloruside prevents growth of a panel of cancer cell lines at low nanomolar concentrations, including cell lines that are resistant to paclitaxel. Three xenograft studies in athymic nu/nu mice were performed to assess the efficacy of peloruside compared with standard anticancer agents such as paclitaxel, docetaxel, and doxorubicin. The first study examined the effect of 5 and 10 mg/kg peloruside (QD×5) on the growth of H460 non-small cell lung cancer xenografts. Peloruside caused tumor growth inhibition (%TGI) of 84% and 95%, respectively, whereas standard treatments with paclitaxel (8 mg/kg, QD×5) and docetaxel (6.3 mg/kg, Q2D×3) were much less effective (%TGI of 50% and 18%, respectively). In a second xenograft study using A549 lung cancer cells and varied schedules of dosing, activity of peloruside was again superior compared with the taxanes with inhibitions ranging from 51% to 74%, compared with ...
METHODS: Eight 6-8 week old female athymic nude mice were randomly selected. ATC cell line ARO cells were injected into the left ventricular cavity of each mouse respectively. Each mouse was imaged using a dedicated small-animal PET/CT scanner after successful injection of [18F]-FDG under deep anesthesia. Pathological examination was carried out to confirm the bone metastases of ATC ...
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Accessible surface proteins of thymus-derived lymphocytes (T-cells) of normal CBA mice and bone-marrow-derived lymphocytes (B-cells) of congenitally athymic nu/nu mice were analysed. The surfaces of lymphocytes were radioiodinated by using the enzyme lactoperoxidase (EC 1.11.1.7), then solubilized either in acid-urea or in the non-ionic detergent Nonidet P-40. These lysates were then precipitated with antisera specific to either immunoglobulin or the θ-alloantigen in order to assess the presence of these surface markers. Comparable amounts of radioactivity in proteins specifically precipitable as immunoglobulin were obtained from T-lymphocytes and B-lymphocytes when the cells were disrupted by acid-urea. This immunoglobulin had mol. wt. approx. 180000 and was composed of light chains and μ-type heavy chains. When radioiodinated lymphocytes were solubilized with Nonidet P-40, 3-4% of radioiodinated high-molecular-weight protein of B-cells consisted of immunoglobulin, a result similar to that ...
Colony counts and light microscopy were used to assess the capacity of Candida albicans to colonize, infect the alimentary tract, and cause disseminated disease in athymic (nu/nu), euthymic (nu/+), beige (bg/bg), black (bg/+), beige athymic (bg/bg nu/nu), or beige euthymic (bg/bg nu/+) germfree mice. The alimentary tracts of all six genotypes of germfree mice were quickly colonized after exposure to yeast-phase C. albicans. Only bg/bg nu/nu mice showed obvious morbidity and mortality after mucosal colonization with C. albicans. Histopathology of C. albicans-colonized immunocompetent (nu/+, bg/+) and singly immunodeficient (nu/nu, bg/bg, bg/bg nu/+) mice showed minimal to moderate mucosal infections, whereas doubly immunodeficient (bg/bg nu/nu) mice showed extensive yeast and hyphal infection of the palate, tongue, esophagus, and stomach. A progressive systemic infection in C. albicans-colonized mice occurred only in bg/bg nu/nu mice 12 to 16 weeks after colonization and mucosal infection. Thus, ...
Toxins. Both PA and LF were expressed and purified as previously described (15, 17).. Cell lines. The human melanoma cell line we chose to use for the s.c. mouse xenograft model was the SK-MEL-28 cell line. SK-MEL-28 cells were purchased from the American Type Culture Collection (Manassas, VA) and grown as recommended in MEM (Eagle) with 2 mmol/L l-glutamine and Earles balanced salt solution adjusted to contain 1.5 g/L sodium bicarbonate, 0.1 mmol/L nonessential amino acids, and 1.0 mmol/L sodium pyruvate, 90%; fetal bovine serum, 10%.. Animals. Female athymic nude mice, 8 to 10 weeks old, were purchased from Charles River Laboratories (Wilmington, MA) and maintained in a ventilated rack system. Irradiated food and autoclaved water were provided ad libitum. The mice were allowed to adjust to their environment for 1 week.. PA-to-LF ratio and timing determination. Athymic nude mice were inoculated s.c. with 10 million SK-MEL-28 melanoma cells. At day 9 post-tumor inoculation, animals were then ...
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In this study, we demonstrate that overexpression of IL-13Rα2 chain inhibits tumorigenicity of human breast and pancreatic tumor cells in nude mice. Although there was no difference in growth between vector only transfected cells and IL-13Rα2 chain transfected cells in vitro, in nude mice, tumorigenicity was impaired in IL-13Rα2 chain overexpressing tumors. The presence of inflammatory cells, particularly neutrophils were found to correlate with the lack of tumorigenicity or significant reduction in tumor growth rate. Neutrophils were found to produce IL-13 and IL-13 had modest antitumor effect in IL-13Rα2 overexpressing tumors. Moreover, IL-13Rα2 overexpressing tumor cells produced high level of IL-8 which has been shown to reduce tumorigenicity in several tumor models. To our knowledge this is the first report that implicates cytokine receptor chain in tumorigenesis.. It is of interest to note that stability of IL-13Rα2 chain expression and tumor growth in nude mice correlated extremely ...
Ricciardi, castagnoli P.; Lieberman, M; Finn, O; Kaplan, D H.; and Leukemia, L I., "Virus in athymic nude mice." (1978). Subject Strain Bibliography 1978. 1049 ...
In this report, we have examined the role of the NT-trk receptor axes in the development and progression of human prostatic carcinoma and PDAC-derived xenografts in nude mice and the consequences of disrupting trk-mediated signaling in these tumor types using a mixture of NT neutralizing antibodies (anti-NGF, anti-BDNF, anti-NT-3, and anti-NT-4/5). We provide evidence that the NT-trk receptor axes are involved in the growth of TSU-Pr1 and PC-3 prostatic carcinoma and AsPC-1 PDAC xenografts. Treatment with the anti-NT antibody mixture inhibited significantly the growth of TSU-Pr1 and AsPC-1 tumor xenografts over a 15-day period and was generally well tolerated. In addition, treatment of nude mice bearing PC-3 tumors with the antibody mixture (400 μg) caused significant tumor regression. The mixture of NT neutralizing antibodies did not inhibit the growth of either the SK-OV-3 or CFPAC xenografts, although each cell line expressed the high-affinity NGF receptor, trkA, supporting previous data ...
Reed, N D.; Isaak, D D.; and Jacobson, R H., "The use of nude mice in model systems for studies on acquired immunity to parasitic helminths, p. 3-16. In proc. Second internat. Workshop nude mice, univ. Tokyo" (1977). Subject Strain Bibliography 1977. 1051 ...
Enumeration and quantification of M. leprae in mouse FPs using conventional assays.BALB/c (gray bars) and athymic nu/nu (black bars) mice were infected in the F
Enumeration and quantification of M. leprae in mouse FPs by molecular assays.BALB/c (gray bars) and athymic nu/nu (black bars) mice were infected in with 3×107
The growth characteristics and metastatic behavior of human tumors growing in athymic nude mice were studied. Human tumor cell lines HEp-2 (carcinoma of larynx) and SW480 (colon carcinoma) were transplanted into athymic nude mice of BALB/c origin. Tumor cells (1 × 106 and 2 × 107) were given either s.c. or i.p.. Following s.c. injection tumors developed rapidly to become easily palpable within 2 weeks forming a s.c. tumor focus surrounded by a thick fibrous capsule. Animals with s.c. transplants were little affected by the growing tumor. At the time they were sacrificed at Day 34 (HEp-2) and 62 (SW480), a large part of the tumor was necrotic. Capsular infiltration and invasion of lymphatic vessels and perineural and perivascular lymphatic spaces were observed. Metastases to regional lymph nodes were seen in animals kept alive for up to 6 months.. Following i.p. transplantation, tumors spread widely in the peritoneal cavity, invaded intraabdominal organs, and metastasized to mediastinal lymph ...
nude mouse definition: a mouse with an inherited problem that prevents all of them from developing locks also stops them from immunologically rejecting personal cells and tissues; popular in preclinical…
4791 Prostate cancer (PCA) remains the most commonly diagnosed visceral cancer in men with more than 230,000 newly diagnosed cases in 2005, and is the second leading cause of cancer deaths among US men. Epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) are potent mitogens that regulate proliferation and survival of PCA cells via autocrine and paracrine loops involving MAPK, Akt and NF-κB-mediated signaling pathways. Recently we showed that inositol hexaphosphate (IP6) inhibits human PCA DU145 xenograft growth in male nude mice, which was associated with its anti-proliferative and apoptotic effects in both in vivo and in vitro PCA systems; however, its mechanism of efficacy is not known completely. Here, we performed detailed mechanistic studies with IP6 to assess and define its effect on growth inhibition and apoptosis in human PCA PC3 cells cultured under serum or starved-condition without or with growth factor stimulation. Cell growth and proliferation were assayed by ...
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The T84 cell line is a transplantable human carcinoma cell line derived from a lung metastasis of a colon carcinoma in a 72-year-old male. Tumor tissue was inoculated subcutaneously and serially transplanted in BALB/c nude mice.
3. Kiguchi, K., Kubota, T., Aoki, D., Udagawa, Y., Yamanouchi, S., Saga, M., Amemiya, A., Nozawa, S., Moossa, A.R., and Hoffman, R.M. A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer. Clinical & Experimental Metastasis 16, 751-756, 1998. ...
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SVEC4-10EHR1 is an endothelial cell line derived from the same solid tumor as SVEC4-10EE2 (see ATCC CRL-2167) in a nude mouse injected with SVEC4-10 (see ATCC CRL-2181). SVEC4-10EHR1 was cloned from cells from the SVEC4-10 induced tumor in 1990 by limiting dilution using medium conditioned by SVEC4-10EE2.
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Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2. ...
A mouse model of metastasis of human gastric cancer is one of the most important tools for studying the biological mechanisms underlying human gastric cancer metastasis. In this paper, we established a mouse model of metastatic human gastric cancer in nude mice that has a higher rate of tumor formation and metastasis than existing models. To generate the mouse model of metastatic human gastric cancer, fresh tumor tissues from patients that have undergone surgery for gastric cancer were subcutaneously implanted in the right and left groins of nude mice. When the implanted tissue grew to 1 cubic centimeter, the mice were killed, and the tumor tissues were examined and resected. The tumor tissues were implanted into nude mice and subjected to pathological examination, immunohistochemical staining, and real-time PCR for cytokeratin 8/18 (CK8/18), E-cadherin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). The mice were also analyzed for metastasis in their
Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the difficulty in obtaining appropriate cell lines and the lack of appropriate animal models. Patient-derived xenograft (PDX) tumor models, bearing ectopically implanted tumors at a subcutaneous site, have been developed. However, these ectopically implanted PDX models have obstacles to translational research, including a low engraftment rate, slow tumor growth, and biological changes after multiple passages due to the different microenvironment. To overcome these limitations, we developed a new method to directly transplant biopsy specimens to the liver of immunocompromised mice. By using two metastatic uveal melanoma cell lines, we demonstrated that the liver provides a more suitable microenvironment for tumor growth compared to subcutaneous sites and that surgical orthotopic implantation (SOI) of
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TY - JOUR. T1 - Antitumor activity of [Pt(O,O-acac)(γ-acac)(DMS)] in mouse xenograft model of breast cancer. AU - Muscella, A.. AU - Vetrugno, C.. AU - Migoni, D.. AU - Biagioni, F.. AU - Fanizzi, F. P.. AU - Fornai, F.. AU - De Pascali, S. A.. AU - Marsigliante, S.. PY - 2014. Y1 - 2014. N2 - The higher and selective cytotoxicity of [Pt(O,O-acac)(γ-acac)(DMS)] toward cancer cell in both immortalized cell lines and in breast cancer cells in primary cultures, stimulated a pre-clinical study so as to evaluate its therapeutic potential in vivo. The efficacy of [Pt(O,O-acac)(γ-acac)(DMS) ] was assessed using a xenograft model of breast cancer developed by injection of MCF-7 cells in the flank of BALB/c nude mice. Treatment of solid tumor-bearing mice with [Pt(O,O-acac)(γ-acac)(DMS)] induced up to 50% reduction of tumor mass compared with an average 10% inhibition recorded in cisplatin-treated animals. Thus, chemotherapy with [Pt(O,O-acac)(γ-acac) (DMS)] was much more effective than ...
Figure 6. A, dietary GSPs inhibit the growth of A549 and H1299 non-small cell lung cancer cells (NSCLC) grown as xenografts in athymic nude mice (29). Tumor xenografts tissues were harvested at the termination of the experiment, and the wet weight of the tumor/mouse in each group is reported in grams as mean ± SD, n = 10. Statistical significance versus non-GSP-treated controls, *, P , 0.05; ¶, P , 0.01; †, P , 0.001. B, tumor xenograft tissues from control and GSP-treated (0.5%, w/w) mice were used for the analysis of the levels of COX-2 and PGE2 receptors using Western blotting. Dietary GSPs inhibit the levels of COX-2 and PGE2 receptors, EP1, EP3 and EP4, in the tumor xenograft tissues grown in athymic nude mice compared with control tumor xenograft tissues. Representative blots from A549 or H1299 xenografts are presented from the independent analysis of tumors from 6 animals per group with identical results. The relative density (arbitrary) of each band after normalization for β-actin ...
TY - JOUR. T1 - Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer. AU - Lee, Young Kwan. AU - So, In Seob. AU - Lee, Sang Chul. AU - Lee, Jeong Hyung. AU - Lee, Chang Woo. AU - Kim, Whan Mook. AU - Park, Mi Kyung. AU - Lee, Seung Taik. AU - Park, Do Youn. AU - Shin, Deug Yong. AU - Park, Chung Ung. AU - Kim, Yeon Soo. PY - 2005/2/1. Y1 - 2005/2/1. N2 - Background: Previous studies have shown that TIMP-2 overexpression is a useful therapeutic tool for inhibiting tumor growth and invasion in animals. However, it has not been reported whether genetic manipulation for TIMP-2 overexpression can induce an inhibitory effect on s0pontaneous metastasis from the primary tumor site to other organs such as lungs or lymph nodes in an animal model. Methods: The present studies describe the effects of retrovirus-mediated TIMP-2 gene transfer into human breast cancer cell lines on the in vitro ...
HCC is one of the deadliest types of cancers, with a mortality of almost 100 % [36]. The mortality of HCC remains high because the disease is typically diagnosed when it is already at an advanced stage, when most potential curative therapies such as resection and transplantation are of limited efficacy. Recent studies reported that different therapies including surgery [5-7], hepatic artery ligation [37], insufficient radiofrequency ablation [38-40], and sublethal heat treatment [41] promoted residual tumor progression. It is especially important to investigate the underlying mechanism. Our research team has developed a safe and reliable method of palliative HCC resection in an orthotopic nude mouse model, and reported that palliative resection enhances metastatic potential of residual HCC in liver [5]. In the present study, using this method, we investigated the precise mechanism mediating this metastasis.. Data from our institution (1958-2008, unpublished) revealed that in HCC patients who ...
We analyzed CP, PP (Peyers patch), and MLN (mesenteric lymph node) cells obtained from 4-week-old athymic (nu/nu) weanling BALB/c mice by flow cytometry (11). All locations had no CD3+ T cells (Fig. 1B) or CD8+ cells, and most CP cells were c-kit+Lin− (Lin; CD3, B220, Mac-1, Gr-1, and TER119) (Fig. 1B), whereas cells from PPs and MLNs (Fig. 1B), and cells from the tissue fragments without CPs, did not have a c-kit+Lin− population. Almost all c-kit+Lin− CP cells were IL-7R+Pgp-1+ (12), 14% of c-kit+Lin− CP cells were CD4+(Fig. 1B), and 68% of c-kit+Lin− CP cells were Thy1+ (Fig. 1B). Four disinct lymphocyte subsets were present among c-kit+Lin− CP cells as determined by the expression of CD4 and Thy1. In the three lymphoid tissues of euthymic nu/+ littermates, only CP cells contained a dominant population (60 to 70%) of c-kit+Lin− cells (12). Thus, CPs differed from PPs and MLNs with respect to lymphoid residents, although they all constitute organized gut-associated lymphoid ...
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In the present study, the antitumor effects of Mel-P15 and the underlying molecular mechanisms of these effects in vivo were investigated. Mel-P15 directly stimulated natural killer (NK) cell cytotoxicity in vitro, which was increased to 55.45% at a 4 µg/ml dose of Mel-P15. In the mouse liver cancer (H22) xenograft mice model, Mel-P15 suppressed tumor growth in vivo; the tumor inhibitory rate was 61.15% following treatment with 2 mg/kg Mel-P15. In addition, the immune response was activated following Mel-P15 treatment. Mel-P15 treatment increased the spleen and thymus indices, promoted splenocyte proliferation, stimulated NK cytotoxicity and upregulated the secretion of cytokines, including interleukin-2, interferon-γ and tumor necrosis factor-α. In addition, the tumor inhibitory effect of Mel-P15 on BEL-7402-bearing nude mice was abrogated by the selective depletion of NK cells via the intraperitoneal injection of an anti-asialo GM-1 antibody ...
In the present study, the antitumor effects of Mel-P15 and the underlying molecular mechanisms of these effects in vivo were investigated. Mel-P15 directly stimulated natural killer (NK) cell cytotoxicity in vitro, which was increased to 55.45% at a 4 µg/ml dose of Mel-P15. In the mouse liver cancer (H22) xenograft mice model, Mel-P15 suppressed tumor growth in vivo; the tumor inhibitory rate was 61.15% following treatment with 2 mg/kg Mel-P15. In addition, the immune response was activated following Mel-P15 treatment. Mel-P15 treatment increased the spleen and thymus indices, promoted splenocyte proliferation, stimulated NK cytotoxicity and upregulated the secretion of cytokines, including interleukin-2, interferon-γ and tumor necrosis factor-α. In addition, the tumor inhibitory effect of Mel-P15 on BEL-7402-bearing nude mice was abrogated by the selective depletion of NK cells via the intraperitoneal injection of an anti-asialo GM-1 antibody ...
In control arm, the tumor grew the fastest within the first couple weeks. As the tumor enlarged, we noticed a decline in growth rate of these tumors. In the control arm, the tumor growth rate was significantly higher in the first 15 days compared to the second 15 days. The tumor volume doubling time changed from 103 h in the first 15 days to 144 h in the second 15 days (P , 0.01). However, in the 2 mg T and 5 mg T arms, the opposite results were found. The data demonstrated that in 2 mg T and 5 mg T arms, the tumor growth rate was significantly lower in the first 15 days compared to the second 15 days, (184 h vs 133 h in 2 mg T arm, P , 0.05, 206 h vs 140 h in 5 mg T arm, P , 0.01). When comparing the growth rates of the control arm and the 2 mg T and 5 mg T arms in the first 15 days, the growth rates were much higher in the control arm (P , 0.01). However, in the second 15 days there was no significant difference in tumor growth rates in the control arm, 2 mg T arm, and 5 mg T arms (Fig. 4). ...