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Abstact:objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional treatment were performed on hemodialysis and assessed the treatment outcome. Results 9 patients (5%) have appeared AKI, including 7 cases of AKI of stage 3. However, there were not any significant correlation between age, gender, serum MTX concentration and AKI, respectively. Compared with normal serum MTX concentration, the patients with high serum MTX concentration easily were developed to AKI, the MTX and serum creatinine concentration had been significantly decreased in 9 patients after hemodialysis. Conclusion AKI has appeared in some children with ALL who receive high dose MTX chemotherapy, and this may due
Methotrexate Side Effect Mouth Sores. Methotrexate Side Effects Mouth Sores - 893308 - AIPCTMethotrexate side effects include mouth sores, unusual bleeding, jaundice, vomiting, hair loss, nausea and more. Methotrexate (By mouth) - National Library of Medicine Methotrexate (By mouth)Why Does Methotrexate Cause Mouth Sores?A possible side effect of taking prescription methotrexate is mucositis, inflammation of the lining of your mouth. Patients taking high doses are even more susceptible. Why Do TNF-Blockers Cause Mouth Sores?Methotrexate Side Effects in Detail - Drugs.comsores in the mouth or lips.Some side effects of methotrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.Methotrexate , The parents version of side effectsSide effects of oral methotrexate. With oral doses, most parents report nausea and skin and eye sensitivity to sunlight."My daughter was also given Carafate after every IV ...
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Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with. Common Questions and Answers about Cipro and methotrexate.Higher frequency of low HDL levels (77% vs. 0%, p=0.0001),. and treatment (current and cumulative doses of prednisone, methotrexate and hydroxichloroquine).methotrexate vs prednisone for lupus when to stop methotrexate in psoriasis Methotrexate and bronchitis, drug interaction bactrim methotrexate.blood versus synovium. prednisone (n=7; range 2-20mg/day), methotrexate (n=11) alone or combined with cyclosporin (n=1) or anti-TNF treatment (n=1), and.. and prednisone; R-CHOP14, rituximab-CHOP regimen at 14. These patients usually receive 4 intrathecal methotrexate injections for prophylaxis although there is.. long term prednisone vs methotrexate for pmr - Arthritis. long term prednisone vs methotrexate for pmr. All information contained within the Johns Hopkins.Sublingual Cialis is used to treat erectile dysfunction in men It might also be ...
Tell your doctor o What Are Some Other Side Effects of methotrexate Tablets? 5mg - Taking 5 tablets at one time, once a week. For oral dosage form (tablets): For cancer: Adults-Dose is based on type of cancer and body size and must be determined by your doctor. 1. Section 6. Rxlist. It is used to treat Avodart 0.5 Mg Soft Capsules rheumatoid arthritis. Intrathecal methotrexate administration at a dose of 12 mg/m2 (maximum 15 mg) has been reported to result in low CSF methotrexate concentrations and reduced efficacy in pediatric patients and high concentrations and neurotoxicity in adult patients How this medicine (methotrexate tablets) is taken may change based on blood work results, side effects, and how well the drug is working. Tell all of your health care providers that you take this medicine (methotrexate tablets). 5 mg every 12 hours for 3 doses once each week. It is also used to treat rheumatoid arthritis, psoriatic arthritis, and psoriasis (a chronic skin disorder that produces patchy ...
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Patients must NOT take sulfa antibiotics, such as co-trimoxazole (Septra) or trimethoprim, while taking methotrexate. Patients should always check with their doctor or pharmacist before starting a new medication.. A doctor should review blood test results every 1-3 months to keep an eye out for any potential side effects to the liver or blood counts. It is important for patients who take methotrexate to remember to get these blood tests done.. Patients taking methotrexate should not drink alcohol.. Methotrexate may cause birth defects and result in miscarriage. Women should AVOID PREGNANCY.. The information sheets given by pharmacists do not distinguish between high and low dose Methotrexate. Arthritis treatment does not involve the high doses used in cancer treatments. The side-effects which may be seen with low-dose Methotrexate include the following:. MORE COMMON side-effects include:. ...
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It is used as a treatment for some autoimmune diseases including: rheumatoid arthritis, psoriasis, psoriatic arthritis, lupus and Crohns disease, to name a few. Although methotrexate was originally designed as a chemotherapy drug (in high doses), in low doses methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases. Because of its effectiveness, low-dose methotrexate is now first-line therapy for the treatment of rheumatoid arthritis. Though methotrexate for autoimmune diseases is taken in lower doses than that of cancer, side effects such as hair loss, nausea, headaches, and skin pigmentation are still common.[2] [3][4] Though not everybody is responsive to treatment with methotrexate, multiple studies and reviews showed that the majority patients receiving methotrexate for up to 1 year had less pain, functioned better, had fewer swollen and tender joints, and had less disease activity overall as reported by themselves and their doctors. X-rays ...
I enjoy your website RheumNow and your weekly highlights. Old guys like me need to be spoon-fed. In regards to mistakes with methotrexate, I have 2 concerns: 1. Many people are being characterized as having CKD based on automated chemistry. Calculated GFRs and CrCls indicate stages 1-4. At what point should I be concerned about methotrexate toxicity? Should I get serum or red cell methotrexate levels or use any of the other testing for methotrexate toxicity available commercially such as 5,10-Methylenetetrahydrofolate reductase (MTHFR) ? Is there a standard of care in the setting of CKD? 2. Please note that the likelihood of methotrexate toxicity in greatly increased when a patient is admitted to a SNF or other long term care situation where weekly meds are unusual. The staff may change qweekly to qdaily because they think there is a typo error. David S. Knapp, MD (semi-retired ...
This study of patients with steroid-dependent asthma failed to find a significant benefit of 12 weeks of methotrexate treatment when compared with placebo. This result appears to refute the original observations of Mullarkey and colleagues, which suggested some benefit from methotrexate in this patient group (1). Several issues need to be considered, however, before methotrexate treatment is abandoned. All studies on this matter have had small sample sizes. Also, patients with severe asthma are not homogeneous with respect to environmental factors triggering their asthma, severity of airflow obstruction, degree of airway hyper-responsiveness, ability to perceive symptoms, or response to therapy. Deciding on the effectiveness of any single therapeutic intervention with such small sample sizes is therefore risky. Mullarkey and colleagues (1) found that methotrexate reduced steroid requirements by 40%; in this study by Erzurum and colleagues, both the placebo and methotrexate groups reduced their ...
Low-dose methotrexate therapy can be used to treat rheumatoid arthritis, asthma, psoriasis, and other inflammatory diseases. When the drug is used for these conditions, the dose is administered weekly or twice a week. Unfortunately, it is not uncommon for the Institute for Safe Medication Practices (ISMP) to receive reports of oral methotrexate overdoses, and even fatalities, due to accidental daily instead of weekly dosing. In one case, a physician decided to add methotrexate 10 mg weekly to a psoriasis patients daily prednisone regimen. Methotrexate 2.5 mg tablets were prescribed with instructions to "take 2 tablets on Monday morning and 2 tablets Monday at bedtime."For some reason, the pharmacy label was unclear to the patient. Because her doctor described the methotrexate as "supplemental therapy to her prednisone," the patient assumed that it was to be taken every day with her prednisone. She took 4 tablets (10 mg) daily for 1 week before being admitted to the hospital due to intolerable ...
This clinical study is scheduled to be performed for the purpose of evaluating the safety and effectiveness of golimumab (CNTO148) administered in combination with stable dose (6-8mg/week) of methotrexate (MTX) to patients with rheumatoid arthritis (RA). CNTO148 50 mg group: CNTO148 50 mg SC injections every 4 weeks from the first administration until week 152. If early escape, 100 mg SC injections every 4 weeks from week 16 until week 152. CNTO148 100 mg group: CNTO148 100 mg SC injections every 4 weeks from the first administration until week 152 whether early escape or not Placebo group: Placebo SC injections every 4 weeks from the first administration until week 20 and then CNTO148 50mg SC injections every 4 weeks from week 16 until week ...
In the multicentre, double-blind, placebo-controlled GO-FURTHER study, patients with active RA despite background MTX therapy received intravenous golimumab 2 mg/kg, or placebo infusions, both in combination with stable MTX therapy, administered as a loading regimen at weeks 0 and 4 followed by q8-week dosing. At baseline, GO-FURTHER patients exhibited more inflammation (median CRP=1.9 mg/ml), greater disease severity per DAS28 scores, and more pronounced disability per HAQ scores than in previously conducted golimumab trials enrolling MTX-experienced patients with active RA (eg, median CRP=0.9 mg/dl in trials evaluating subcutaneous3 and intravenous5 golimumab). The degree of baseline active inflammation, disease severity and disability in the GO-FURTHER trial was actually more comparable with the ATTRACT study of infliximab (median CRP=2.6 mg/dl),17 which was conducted prior to the adoption of a revised approach to treating patients with RA, that is, at a time when clinical trials of RA ...
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Infusions with high-dose methotrexate 5 g/m2 or 8 g/m2 are according to the protocol of the Nordic Association for Pediatric Hematology and Oncology 2000 (NOPHO-2000) used to treat children with acute lymphoblastic leukemia (ALL). Treatment with methotrexate 5 g/m2 is also used to treat children with non-Hodgkin lymphoma, medulloblastoma and ependymoma. Methotrexate is primarily excreted unchanged by the kidney where it can course acute nephrotoxicity resulting in prolonged elimination time of the drug. Data from a 10 years retrospective investigation at our pediatric unit show, that in spite of urine alkalinization and intensive hydration the elimination of methotrexate is prolonged in 20-50% of the infusions. The long exposure of a high serum methotrexate concentration is associated with an increased frequency of mucositis and bone marrow suppression. Further more the need of rescue with folic acid is problematic, because it is possibly that it can result in a higher risk of relapse of ALL ...
Methotrexate is an antineopalstic agent widely used in low dose to treat patients with rheumatoid arthritis. It is known to induce micronuclei at multiple doses in rats. The present study investigates the effect of vitamin A on methotrexate-induced micronuclei in rat bone marrow erythrocytes. Male wistar rats were (n=5) injected with 0, 8, 16 and 20mg/kg methotrexate (single i.p dose). A group of rats received 5000 IU of vitamin A (i.p) for 4 successive days. Another group of rats received a combination of vitamin A (5000 IU of vitamin A for 4 successive days) and single dose of methotrexate (20mg/kg dose). Samples were collected at 24 hours after last methotrexate exposure in to 5% bovine albumin. Smears were obtained and stained with May-Grunwald and Giemsa. Thousand polychromatic erythrocytes were counted per animal for the presence of micronuclei and PCE% was also calculated. The percentage of micronuclei increased with increase in the dose of methotrexate (percentage of PCE decreased with ...
Learning to Self Inject Methotrexate at Home Developed by Andy Thompson MD FRCPC and Marie J Craig-Chambers B.Sc.Phm Why might my Doctor ask me to inject Methotrexate? Methotrexate comes in two forms:
Methotrexate is a folate antagonist and one of several first-line disease-modifying drugs for treating rheumatoid arthritis. It can be given orally or parenterally: the bioavailability of oral doses of methotrexate is highly variable, being only two-thirds of that by parenteral use. The most frequent side effects are nausea and vomiting, and the most serious are toxicity of the bone marrow, liver, kidney and mucosa. Being hydrophilic, methotrexate barely penetrates the blood-brain barrier so that central nervous system toxicity is rare. However, this may follow intrathecal or high-dose intravenous administration, as used to treat haematological malignancies. There are a few case reports of leukoencephalopathy after low-dose oral methotrexate, involving the temporal and/or occipital lobes or the cerebellum.1 Subcutaneous administration of methotrexate seems to give a better clinical response and fewer side effects than oral methotrexate.2 Nevertheless, we recently observed a woman … ...
To the editor: We read with interest the report of Nordstrom and coworkers (1) on radiographic progression in 18 patients with refractory rheumatoid arthritis treated with low-dose methotrexate in a prospective open study. Each patient had three sets of hand, wrist, and foot radiographs: the first set within an average of 33 months before methotrexate therapy, the second at the start of therapy, and the third at an average of 30 months after the start of therapy. Methotrexate may not be a disease-modifying drug because the two rates of radiologic progression before and during therapy were not significantly different.This result ...
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Induction chemotherapy. High dose Methotrexate: The efficacy of Methotrexate in the treatment of Primary CNS lymphoma was first demonstrated by Ervin & Canellos in 1980 [17]. The primary CNS lymphoma cells inside brain are more sensitive to MTX and thus HD-MTX forms the backbone of PCNL therapy. HD-MTX is also shown a treatment related prognostic marker for survival in these patients [18]. There is no firm definition of HD-MTX and doses from 1g/m2 to 8 g/m2 has been reported in clinical trials [19]. Importantly Lippens and colleagues [20] demonstrated that intravenous administration of Methotrexate over 3 hours (3g/m2) leads to superior concentrations in cerebrospinal fluid (CSF) than infusion over 24 hours. Despite detectable meningeal disease in up to 15 % patients at diagnosis, intrathecal therapy has failed to achieve significantly better outcome [21]. Glantz et al demonstrated higher CSF levels after intravenous Methotrexate (8g/m2) than intrathecal injection with 12g/m2 Methotrexate [16]. ...
We recently cloned and characterized the rat kidney-specific organic anion transporter, OAT-K1, which was suggested to mediate renal tubular transport of methotrexate. In this study, we investigated the interactions of nonsteroidal anti-inflammatory drugs (NSAIDs) with OAT-K1 by evaluating the effects of these drugs on renal distribution of methotrexate in vivo, and on methotrexate accumulation in the stably transfected LLC-PK1 cells expressing OAT-K1 (LLC-OAT-K1). NSAIDs such as indomethacin and ketoprofen had significant inhibitory effects on renal accumulation of methotrexate in rats after coadministration. Indomethacin and ketoprofen inhibited methotrexate accumulation by LLC-OAT-K1 cells in a competitive manner with the apparent inhibition constant values of 1.0 mM and 1.9 mM, respectively. Other NSAIDs including ibuprofen, flufenamate and phenylbutazone also showed potent inhibitory effects on methotrexate accumulation. However, indomethacin was not transportedvia OAT-K1. These results ...
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Background: Methotrexate (MTX) is a folate antagonist used in the management of rheumatoid arthritis and as an antimetabolite in cancer chemotherapy. MTX toxicity following parenteral administration is well described, predictable on the basis of timed serum concentrations, and preventable by the administration of folinic acid. Although MTX toxicity has never been reported fol- lowing single oral overdose, many authorities recommend treatment with folinic acid. The objective of this study was to describe the clinical course following acute MTX ingestion and the utilization of MTX levels in refining the risk assessment. Methods: Following institution of a standard management protocol for acute MTX ingestion at the NSW Poisons information Centre, data was prospectively collected on all acute intentional or unintentional ingestions of methotrexate reported to the centre. The proto- col withheld immediate administration of folinic acid for ingestion of , 500 mg in adults or , 5 mg/kg in children, ...
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ABSTRACT. This study was designed to determine the kidneys of an enlarged hydroxide antacid and a blood carbonate antacid on the bioavailability of ciprofloxacin (Cipro). Methotrexate and ckd ( mg) was bad orally to 12 healthy subjects in a three-way randomized crossover design. The three months included Cipro. Pharmaceuticals as needed methotrexate and ckd of surface and thought water around the pronounced communities and residential meters received growing attention recently. That, there is no report on ciprofloxacin (CIP) conformation using electrocoagulation (EC) process by intravascular electrodes, the present work deals with. Background: Methotrexate (MTX) elimination is reduced in patients with impaired renal function (a common co-morbidity in rheumatic disease), increasing the risk of MTX toxicity. There is no clear consensus on MTX dose adjustment in patients with chronic kidney disease (CKD). The BSR. DMARD monitoring. Methotrexate (MTX) use can be associated with a variety of adverse ...
Methotrexate is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would Methotrexate Tablet 2.5mg develop into placenta). The other ingredients are: Lactose monohydrate, maize starch, starch, pregelatinised (potato starch), polysorbate 80, cellulose, microcrystalline and magnesium stearate METHOTREXATE is a chemotherapy drug used to treat cancer including breast cancer, leukemia, and lymphoma. It is used to treat many cancers and other medical conditions. G. The active substance is methotrexate, each tablet contains 2. Methotrexate 2. 5 mg Tablets (methotrexate) Package Leaflet: Information for the User Your medicine is known by the above name but will be referred to as. 5mg, tell your doctor or pharmacist your medical history,liver disease, kidney disease, lung disease (such as pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, stomach/intestinal diseases (such as peptic ulcer, ulcerative colitis), any active infection ...
Can I have vaccinations whilst on methotrexate?. It is recommended that you should not be immunised using any of the live vaccines such as MMR (measles, mumps, rubella), polio and yellow fever. An inactivated polio vaccine can be given instead of the live one and the inactivated version should also be given to people you are in close contact with, e.g. members of your household.. If you are on methotrexate you should avoid contact with children who have been given the live polio vaccine, for 4-6 weeks after the vaccination. This precaution is not necessary if inactivated polio vaccine is given. If you require immunisation with a "live" vaccine, methotrexate should be stopped 6 months before the vaccination and not prescribed until 2 weeks after the vaccination has been given. Yearly flu and five yearly Pneumovax vaccinations are safe and recommended. However, the new nasal flu vaccination is a "live" vaccine and should not be given to patients on methotrexate (see Patient Information ...
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BACKGROUND: Interfant-99 was an international collaborative treatment protocol for infants with acute lymphoblastic leukemia (ALL). PROCEDURE: We collected data on 103 infants at the time of their first treatment with high-dose methotrexate (HD MTX), 5 g/m(2). Children ,6 months of age received two-third of the calculated dose based on body surface area (BSA), children 6-12 months three-fourth of the calculated dose, and children ,12 months full dose. RESULTS: The median steady-state MTX concentration at the end of the 24-hr infusion was 57.8 microM (range 9.5-313). The median systemic clearance was 6.22 L/hr/m(2) BSA, and tended to increase with age (P = 0.099). Boys had higher clearance than girls, 6.77 and 5.28 L/hr/m(2) (P = 0.030), and tended to have lower median MTX concentration at 24 hr. Eight infants had MTX levels below 20 microM, a level judged to be sufficient in B-lineage ALL in children ,1 year of age. All infants tolerated the dose well enough to receive a second dose of HD MTX ...
TY - JOUR. T1 - Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice. AU - Chandraprakash, K. S.. AU - Udupa, N.. AU - Umadevi, P.. AU - Pillai, G. K.. PY - 1990/6/11. Y1 - 1990/6/11. N2 - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.. AB - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.. UR - http://www.scopus.com/inward/record.url?scp=0025314159&partnerID=8YFLogxK. UR - ...
T-cell biology has regained importance in the pathogenesis of rheumatoid arthritis. Despite the significant improvements associated with the introduction of tumor necrosis factor-α blockade, reasonable proportions of failures and suboptimal responses have been reported, necessitating a search for alternative targeted therapies. This has included drug therapy designed to interrupt T-cell activation via the co-stimulation pathway. Abatacept is a recombinant fusion protein that blocks the co-stimulatory signal mediated by the CD28-CD80/86 pathway, which is required for T-cell activation. Several clinical trials have confirmed the safety and efficacy of this drug in the treatment of rheumatoid arthritis. This review summarizes the clinical data supporting this line of treatment and considers the safety and efficacy data from phase II and III trials.
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The position paper (1) on methotrexate in rheumatoid arthritis should have included the following introductory paragraph:. The square-bracketed numbers in this article are references to the numbered paragraphs in the review article in this issue ("Methotrexate in Rheumatoid Arthritis: Indications, Contraindications, Efficacy, and Safety; " see pages 358-366) that support statements made here. -The Editor.. Also in the position paper, the word "contraception" inadvertently appeared where the word "conception" should have been used. This substitution occurs in the section on contraindications; the sentence should read:. . . . pregnancy or chance of pregnancy (for men or women), appropriate steps should ...
Results Mean age was 61 years, 63% were female, and 90% were white. Patients had a mean body mass index of 30.7 kg/m2 and 13-year disease duration. PK analysis of MTXAI (thigh) vs. oral MTX showed that the BA of MTXAI was consistently greater at all dose levels (see figure). PK measures for MTXAI thigh and MTXAI abdomen were similar. Oral MTX exposure plateaued above 15 mg; however, no plateau was seen with MTXAI administration, which resulted in a higher exposure than the comparable oral dose. The relative BA (AUC of MTXAI vs. oral MTX) at 10, 15, 20, and 25 mg was 121%, 114%, 131%, and 141%, respectively. The ratio of the dose-normalized AUC (0-24 h) and Cmax of MTXAI vs. oral MTX was 127.61 (90% CI: 122.30-133.15) and 94.88 (90% CI: 87.95-102.37), respectively. There were 2 SAEs which were considered unrelated to treatment, including a death from a myocardial infarction in a 79-year-old man with a prior cardiac history. The treatments in both the MTX and MTXAI arms were otherwise generally ...
Methotrexate is a cornerstone of disease-modifying antirheumatic drug therapy for rheumatoid arthritis. It is an analogue of folic acid and thus classed as an antimetabolite. Methotrexate inhibits dihydrofolate reductase (which converts dihydrofolate to tetrahydrofolate), but the mechanism of action in rheumatoid arthritis is unclear.. On average, 30% of patients cease methotrexate within one year due to adverse effects and 60% experience mild adverse effects.20 Gastrointestinal intolerance and transaminase elevation are the main reasons for dose reduction or cessation. The risk factors for methotrexate toxicity include alcohol use, obesity (≥ 8% hepatotoxicity with body mass index 20-25; ≥ 20% hepatotoxicity with body mass index 30-35), older age and folate deficient status.. Concurrent folic acid supplementation reduces elevations of hepatic transaminases, gastrointestinal intolerance and stomatitis, and may increase the maximum tolerated dose of methotrexate.21 Supplementation does not ...
Abstract: To evaluate the effect of methotrexate on collagen-induced arthritis, micro-computed tomography (micro-CT) and histopathological analyses were used in male Wistar rats. Rats were divided randomly into three groups. Group 1 was treated with 0.9% saline, and groups 2 and 3 were boosted with type Ⅱ collagen. From day 21 to 42, groups 1 and 2 were orally treated with 0.9% saline and group 3 was orally treated with 1.5 mg/kg methotrexate. All rats were sacrificed at day 42 after the first collagen treatment. Micro-CT analyses showed bony parameters, such as bone volume and trabecular number, were decreased in group 2 compared to group 1, and these parameters were recovered in group 3. Histopathological examination and pathological parameter scoring showed that the knee joints of rats in group 2 had severe joint destruction, showing cartilage and bone erosion, enlarged cavities with inflammatory cell infiltration and activation of synovial fibroblasts. By contrast, these changes were ...
Methotrexate (MTX)-associated myelopathy is a rare but serious subacute complication of MTX-based chemotherapy. We report the case of a woman with breast cancer and meningeal carcinomatosis who developed severe progressive myelopathy after four cycles of intrathecal MTX administration. We substituted high doses of the key metabolites of the methyl-transfer pathway: S-adenosylmethionine (SAM), 200 mg three times daily i.v.; folinate, 20 mg four times daily i.v.; cyanocobalamin, 100 mug once daily i.v.; and methionine, 5 g daily p.o. The patients paraparesis improved rapidly thereafter, and magnetic resonance (MR) imaging showed resolution of the intramedullary lesions. Genetic analyses revealed homozygosity for the A allele of methylenetetrahydrofolate reductase (MTHFR) c.1298A,C (p.E429A), whereas other genetic variants of folate/methionine metabolism associated with MTX neurotoxicity were not present. Substitution with multiple folate metabolites may be a promising strategy for the treatment ...
The chromosomal locations, amounts, and level of expression of transfected, amplified c-myc and dihydrofolate reductase sequences were measured in cells cultured in the presence and absence of methotrexate. These studies show that the location and amount of transfected sequences, as well as the level of expression, were more variable when the cells were cultured in methotrexate.. Keywords: Animals ; DNA Probes ; DNA ; Recombinant/genetics ; Gene Amplification/*drug effects ; Gene Expression Regulation/drug effects ; Methotrexate/*pharmacology ; Mice ; Nucleic Acid Hybridization ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-myc ; Proto-Oncogenes ; Tetrahydrofolate Dehydrogenase/genetics ; Transfection. Note: Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California 94550.. ...
The approximate incidences of adverse reactions reported in pediatric patients with JIA treated with oral, weekly doses of methotrexate (5 to 20 mg/m2/week or 0.1 to 0.65 mg/kg/week) were as follows (virtually all patients were receiving concomitant nonsteroidal anti-inflammatory drugs, and some also were taking low doses of corticosteroids): elevated liver function tests, 14%; gastrointestinal reactions (e.g., nausea, vomiting, diarrhea), 11%; stomatitis, 2%; leukopenia, 2%; headache, 1.2%; alopecia, 0.5%; dizziness, 0.2%; and rash, 0.2%. Although there is experience with dosing up to 30 mg/m2/week in JIA, the published data for doses above 20 mg/m2/week are too limited to provide reliable estimates of adverse reaction rates ...
1U71: Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
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Dr. Lewis responded: Yes, by specialist. The combination can result in increased levels of |a href="/topics/methotrexate" track_data="{
Methotrexate carried in lipid core nanoparticles reduces myocardial infarction size and improves cardiac function in rats Raul C Maranhão,1,2 Maria C Guido,1 Aline D de Lima,1 Elaine R Tavares,1 Alyne F Marques,1 Marcelo D Tavares de Melo,3 Jose C Nicolau,3 Vera MC Salemi,3 Roberto Kalil-Filho3 1Laboratory of Metabolism and Lipids, 2Faculty of Pharmaceutical Sciences, 3Heart Failure Unit, Clinical Cardiology Division, Heart Institute (InCor), Medical School Hospital, University of São Paulo, São Paulo, Brazil Purpose: Acute myocardial infarction (MI) is accompanied by myocardial inflammation, fibrosis, and ventricular remodeling that, when excessive or not properly regulated, may lead to heart failure. Previously, lipid core nanoparticles (LDE) used as carriers of the anti-inflammatory drug methotrexate (MTX) produced an 80-fold increase in the cell uptake of MTX. LDE-MTX treatment reduced vessel inflammation and atheromatous lesions induced in rabbits by cholesterol feeding. The
Thirty mature and peripubertal male rabbits were examined for endocrine function and tissue methotrexate (MTX) concentration after single (57.5 mg/kgBW, group 1) and repeated (6 mg/kgBW, once a week for 14 weeks, group 2) MTX doses. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and androstenedione plasma levels were measured by radioimmunoassay (RIA). We found elevated plasma FSH levels in both groups. Elevated plasma androstenedione level and reduced plasma testosterone level in group 2 suggest an enzymatic defect in the gonadal steroid synthesis. Unchanged LH plasma level, when compared to controls, is thought to be the result of a combined effect of MTX on the gonadal steroids and gonadotropin synthesis.