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К ВОПРОСУ О ВЫБОРЕ ОПЕРАТИВНОГО ДОСТУПА И ВЫНУЖДЕННЫХ СИМУЛЬТАННЫХ ОПЕРАЦИЯХ
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Several models have been proposed to analyse dose-response curves recorded in bronchoprovocation challenge tests. The aims of the present work were: 1) to investigate which model (linear vs exponential) and which minimization method (trials and errors vs Levenberg-Marquardt) gives better results in terms of data interpolation (goodness-of-fit); and 2) to verify the validity of extrapolation by comparing forced expiratory volume in one second (FEV1) observed after 4 mg methacholine with values extrapolated after truncation of the curves at 2 mg. For these purposes, methacholine dose-response curves were obtained in 832 subjects from a random population sample, as part of the European Community Respiratory Health Survey (ECRHS) in Italy. Methacholine was inhaled up to a maximum dose of 6 mg by dosimeter technique. The coefficient of determination (r2) was significantly higher with the exponential model (0.81 +/- 0.22; mean +/- SD) than with the linear model (0.69 +/- 0.27). With both models, ...
The purpose of the first part of this study was to develop computerized techniques for automation of instrument calibration, data collection and calculation of indices of pulmonary mechanical function in resting and exercising horses. The microcomputer system developed enabled a single trained technician to reliably operate the equipment in an equine pulmonary mechanics laboratory. The first experiment investigated the temporal effects of histamine and methacholine aerosols on indices of pulmonary mechanics derived from the linear equation of motion. Data calculated on a breath-by-breath basis were too variable to be reliably modeled. Following application of averaging techniques, the temporal effects of histamine and methacholine on respiratory rate were the most predictable of all the response variables studied. In experiment two, normal tidal breathing flow-volume loops (TBFVLs) of resting horses were characterized. In excess of 90% of the variance of 10 TBFVL indices were summarized by a factor
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Dose-response curves to methacholine were examined in 9 normal and 10 asthmatic volunteers to determine whether the relationship between dose and response can be adequately summarized by means of a single, continuous measure that is not censored at lower levels of bronchial responsiveness. Subjects …
As the usual bronchial provocation tests with methacholine are rather cumbersome and time-consuming, an attempt has been made to develop a short screening test for routine use. 143 patients with chronic cough or intermittent dyspnea received methacholine from a pressurised aerosol (puffer). The response was evaluated by spirometric measurement. Among 74 patients with chronic cough, 49 had a favourable response to methacholine. 93% were treated successfully with a bronchodilator. Among 62 patients with dyspnea, 45 reacted favourably to methacholine. All were treated successfully with bronchodilators. The short provocation test protocol with methacholine is easy and safe to perform. In cases of chronic cough and dyspnea it serves to detect hyperreactive patients who can benefit from bronchodilator treatment.
During the screening visit, subjectsvital signs (heart rate, blood pressure and temperature) will be measured and they will perform standard spirometry. If the results of this test are 70% of normal or greater, they will be examined by a physician, and blood (1 teaspoonful) and urine will be collected for routine laboratory tests (CBC and routine urinalysis). If they are a female, a pregnancy test will be performed.. During the second visit, subjects will inhale 1 or 2 doses of formoterol, (Foradil Aerolizer 12 mcg/capsule) a long-acting bronchodilator and 1 hour later, perform a methacholine test.. At the end of the methacholine test, they will be given albuterol to reverse the effects of methacholine. On the third study day, they will repeat the second visit but with the opposite dose of Foradil. ...
1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline.. 2. After urea ventilatory capacity was impaired in 68% of subjects and improved in 16%. This response was a relatively constant phenomenon in the same subject. Urea appears to possess the unusual property of being able to produce both bronchoconstriction and bronchodilatation. The response could not be related to any of the clinical or other physiological variables examined.. 3. Mild hypoxaemia, ventilation-blood-flow inequality and impairment of gas transfer also occurred after urea administration.. 4. Methacholine produced considerable impairment of ventilatory capacity with consistent hyperinflation but with variable changes in ventilatory pattern and distribution of ventilation.. 5. Isoprenaline rapidly and completely reversed ...
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The IUPHAR/BPS Guide to Pharmacology. methacholine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
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Pavlov made known the results of his research in this field, which is of great importance in practical medicine, in lectures which he delivered in 1895 and published under the title Lektsii o rabote glavnykh pishchevaritelnyteh zhelez (Lectures on the function of the principal digestive glands) (1897 ...
We studied the effect of mild isocapnic hypoxia (FIO2 = 15.5%) on lung mechanics, heart rate, circulating plasma catecholamines, and bronchial responsiveness to methacholine in ten asthmatic adults. Hypoxia did not alter lung mechanics (i.e., dynamic pulmonary compliance [CLdyn], pulmonary resistanc …
Dr. Anand responded: Methacholine test. The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results. Some times the answer may not be clear cut.
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The idea of having the cooling exit duct co-axial with the exhaust outlet was very popular in the early 2000s, and the reason is that the flow of exhaust gases can be used the increase the mass-flow rate through the cooling system, a phenomenon sometimes referred to as aspiration. If you pull the flow out of the cooling system more quickly, you can get the same mass-flow rate for a smaller inlet area, and a smaller inlet provides aerodynamic benefits. This concept was studied by Parra and Kontis in their 2006 paper, Aerodynamic effectiveness of the flow of exhaust gases in a generic formula one car configuration, published in the The Aeronautical Journal ...
The idea of having the cooling exit duct co-axial with the exhaust outlet was very popular in the early 2000s, and the reason is that the flow of exhaust gases can be used the increase the mass-flow rate through the cooling system, a phenomenon sometimes referred to as aspiration. If you pull the flow out of the cooling system more quickly, you can get the same mass-flow rate for a smaller inlet area, and a smaller inlet provides aerodynamic benefits. This concept was studied by Parra and Kontis in their 2006 paper, Aerodynamic effectiveness of the flow of exhaust gases in a generic formula one car configuration, published in the The Aeronautical Journal ...
15:30. Serba E.O.*, Popov Sergey Dmitrievich**, Surov A.V.***, Nakonechny G.V.****, Nikonov A.V.*****, Spodobin V.A.******, Subbotin D.I.*******, Pavlov A.V.*, Kiselev A.A.****** ...
My humble answer: There really is no difinitive test to diagnose asthma. However, the methacholine challenge is a pretty significant indicator. If you have a negative methacholine challenge chances are you dont have asthma. The reason I can say this is because if you have asthma the challenge will make you short of breath, and a bronchodilator breathing treatment will make you feel better. If none of these happen, chances are you dont have asthma. A second opinion is always a good idea, however. ...
Smiths Medical Asthma Patient Testing Kit (Methacholine Bronchoprovocation) is a convenient, all-inclusive procedural kit for the assessment of the respiratory
In the 1890s, Pavlov was investigating the gastric function of dogs by externalizing a salivary gland so he could collect, measure, and analyze the saliva and what response it had to food under different conditions. He noticed that the dogs tended to salivate before food was actually delivered to their mouths, and set out to investigate this psychic secretion, as he called it. He carried out a series of experiments while changing the stimuli before the dogs were presented with food. His discoveries made him a highly regarded man by the Soviet government, and even Lenin himself helped Pavlov in regard. He died in Leningrad in 1936. Conscious until his very last moment, Pavlov asked one of his students to sit beside his bed and to record the circumstances of his dying. He wanted to create unique evidence of subjective experiences of this terminal phase of life ...
Russian photographer Andrey Pavlov spends hours setting up fairytale scenes. He studied ants, and saw that they all follow a very specific path when theyre working. So he put his props on their trail, and photographed the insects interacting with his min
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ИССЛЕДОВАНИЕ ПОКАЗАТЕЛЕЙ ОКИСЛИТЕЛЬНОГО СТРЕССА В КРОВИ БОЛЬНЫХ ОСТЕОАРТРОЗОМ КОЛЕННОГО СУСТАВА
Rationale: Methacholine and mannitol challenges are used clinically to assess airway hyperresponsiveness (AHR). Cough during (a) high-dose methacholine challenge in individuals with methacholine-induced cough and normal airway sensitivity and (b) mannitol challenge in some individuals with asthma both occur in the absence of significant declines in forced expiratory volume in one second (FEV1). We hypothesized mechanical responses to these challenges would reflect a continuum amongst subjects with: (i) asthma; (ii) cough variant asthma (CVA) and (iii) methacholine-induced cough and normal airway sensitivity due to varying degrees of impairment/preservation of the beneficial effects of deep inspirations. Purpose: To compare cough and airway responses to mannitol and high-dose methacholine challenges between these groups. Methods: Individuals with asthma or suspected CVA were invited to participate. Subjects were challenged with mannitol and high-dose methacholine in random order 2-14 days apart. ...
TY - JOUR. T1 - Methacholine inhalation challenge studies in a selcted pediatric population. AU - Hopp, R. J.. AU - Bewtra, A. K.. AU - Nair, N. M.. AU - Watt, G. D.. AU - Townley, R. G.. PY - 1986. Y1 - 1986. N2 - To determine bronchial reactivity patterns, 400 subjects, 5 to 21 yr of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or allergy was based on a respiratory questionnaire. Subjects were nonsmokers and had had no respiratory infections for 1 month. Intradermal skin tests were done. The methacholine challenge response was expressed as the area beneath the dose-response curve (Area35). Fifty-five asthmatics, 113 normal subjects from normal families, 103 normal subjects from asthma families, 60 normal twins, and 69 allergic subjects without asthma were studied. Overall, 52% of nonasthmatics and 47% of nonallergic subjects had an Area35 less than 4,000 (800 breath units). There was a difference (p , 0.05) in the distribution of ...
Publications:. Chronic Cough in Mahan Buttaro T and others, editors: Primary Care, a Collaborative Practice, St. Louis; Mosby; 1999: 312-315, first edition. Second edition, 2003.. The Effects of Methacholine on Cough Sounds Spectra: AM J Resp and Crit C Med., April 1995; 151 (4), A394. Research:. A Comparison of High Dose versus Low Dose Steroids in Acute Exacerbation of COPD. Department of Pulmonary Medicine, St. Elizabeths Medical Center, Boston, MA. Primary Investigators: Drs. S. Del Re, B. Celli.. Mechanism of Swallowing and Aspiration. Department of Pulmonary Medicine, St. Elizabeths Medical Center, Boston, MA, Primary Investigators: Drs. R. Gilbert and S. Del Re.. Effects of Azithromycin on CNS Toxoplasmosis in HIV Patients. Multicenter Trial: Department of Medicine, Lutheran Medical Center, Brooklyn, NY, Primary Investigator Dr. P. Decapreris.. ...
Methacholine Chloride: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
The results of these experiments in anaesthetised Brown Norway rats show that prolonged inhalation of methacholine results in a predominantly parenchymal (or tissue) constrictor response which is effectively reversed by a maximum dose of atropine sulphate but not by pirenzepine. In contrast, intravenous methacholine produced more marked changes in airway resistance which were reversed by pirenzepine.. Our adaptation of the low frequency forced oscillation technique allows lung mechanics to be partitioned into airway and parenchymal components by fitting the constant phase model to the impedance spectra. The airways through which gas moves by bulk flow will be included in the airway component, whereas airways through which gas moves by diffusion are likely to be included in the parenchymal component. It is therefore most likely that the parenchymal response is the result of contraction of smooth muscle in respiratory bronchioles and alveolar ducts and of contractile elements in the alveolar ...
During the course of building an animal style of chronic asthma, we attempted to elucidate enough time sequence of airway hyperresponsiveness (AHR), airway inflammation, airway redecorating, and linked cytokines. be significant statistically. Outcomes Airway responsiveness To research the relationship with airway redecorating, AHR to methacholine was examined in each best period stage. Fig. 2 displays the dosage response curve of airway responsiveness to methacholine. In each OVA-exposed asthma group, airway responsiveness to methacholine was increased weighed against control group significantly. But there is no factor in AHR between your asthma organizations. Fig. 2 Airway hyperresponsiveness to methacholine in each combined band of mouse asthma magic size. Weighed against the control group, asthma organizations showed significantly improved airway hyperresponsiveness for 12 weeks (*… Immunocytochemical staining for TIMP-1 and MMP-9 Weighed against control mice, MMP-9 and TIMP-1 expressions ...
As soon as your lungs show a significant worsening in lung function, with a drop in forced expiratory volume at 1 second (FEV1) of 20% or more, the test is considered complete. You will be given an inhaled bronchodilator treatment (usually albuterol or levalbuterol) to help re-open your airways. You will then repeat the spirometry test to make sure your lungs have returned to normal. The concentration of the methacholine given at this point will be your test result. If you do not have a drop in function or symptoms, the last dose given is the result ...
Looking for Pavlov theory of schizophrenia? Find out information about Pavlov theory of schizophrenia. Born Mar. 5 , 1872, in Popovka, in what is now Tula Oblast; died Aug. 30, 1951, in Moscow. Soviet engraver. Peopless Artist of the RSFSR . Member of the... Explanation of Pavlov theory of schizophrenia
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Asthma, Rhinitis, Risk, Population, Adults, Allergy, Association, Bronchi, Mite, Nose, Risk Factor, Risks, Classification, Electrodiagnosis, Syndrome, Adult, Bronchial Hyperreactivity, Children, Methacholine, Odds Ratio
One of the more famous experiments mentioned in general psychology textbooks is the Pavlov dog experiment, which described unconditioned and conditioned responses. Describe the principles behind the experiment and how it fits.
Delivery of modified Krebs-Henseleit solution (MKHS) of raised osmolarity (added NaCl or KCl) to the lumen of methacholine (MCh)-contracted IPT results in a relaxation response of the airway smooth muscle that is mediated by epithelium-derived relaxing factor (EpDRF). We compared the effects of luminally-applied solutions containing organic osmolytes added to MKHS to raise osmolarity (hypertonic s
Massaggio prostatico a cu eosinophilic. Archivio pubblicazioni 2019-2019. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine. Mani massaggio prostatico russo iperplasia di VC, cura per il mese della prostata come C est l infection, aiguë ou chronique, de la prostate (glande. Qual è il massaggio prostatico BPH prostata Calcinate, orchiectomia per ho fatto pipì e pyknotic B cells of the acinar nodule have a pale, eosinophilic cytoplasm. were generated with fluorescent tagged proteins at the C-terminus of P2X4R..
Methacholine tests are widely used as a diagnostic aid for asthma. Their strength has been reputed to be the high sensitivity and very infrequent occurrence of ...
Detailed dosage guidelines and administration information for Provocholine (methacholine chloride). Includes dose adjustments, warnings and precautions.
Above, a video visualizing two of our participants ECG responding to music in real-time. Yellow and green lines represent their ECGs, red the level of synchrony between them. The audio is a live recording of … ...
TY - JOUR. T1 - IgE levels and methacholine inhalation responses in monozygous and dizygous twins. AU - Townley, R.. AU - Guirgis, H.. AU - Bewtra, A.. PY - 1976/1/1. Y1 - 1976/1/1. UR - http://www.scopus.com/inward/record.url?scp=0017256177&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017256177&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0017256177. VL - 57. SP - No.93. JO - Journal of Allergy and Clinical Immunology. JF - Journal of Allergy and Clinical Immunology. SN - 0091-6749. IS - 3. ER - ...
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Local Lung Function And Airway Size Response During Methacholine Challenge And Salbutamol Treatment Measured Using High-Resolution Dynamic CT And Functional Lung Imaging
The 547 asymptomatic subjects with normal pulmonary function were grouped according to quintile of prechallenge FEV, (percent predicted), and the fifth percentiles of PD20FEV, within each quintile of FEV, were calculated (Table 2). The fifth percentile of methacholine PD20FEV, increased with increasing quintile of prechallenge FEV,. This relationship is shown graphically in Figure 1, in which the fifth percentile of PD20FEV, for each quintile is plotted against the median FEV, for that quintile. Restricting analysis to a subgroup of 157 lifetime nonsmokers yielded similar values for the fifth percentiles of PD20FEV,, for both overall and FEV,-specific percentiles (data not shown). canadian health & care mall. The overall fifth percentile of PD20FEV, (8.3 (imol) and the FEV,-specific fifth percentiles of PD20FEV, (as indicated in Table 2) respectively defined the 26 (4.8 percent) and 27 (4.9 percent) most responsive subjects among the 547 asymptomatic men. Seventeen (3.1 percent) men were ...
Bronchial hyperresponsiveness (BHR) is a hallmark of asthma. BHR to methacholine is used for diagnosis, but the role in monitoring treated asthma is not established. In the present study we assessed the relation between BHR to methacholine, airways inflammation, asthma control and symptoms.. Methacholine challenge and FeNO measurements were done in 371 asthmatics (aged 10-35 years) with inhaled corticosteroids prescribed. PD20 ,0.3 mg defined moderate-severe BHR, 0.3 to 1.0 mg borderline-mild BHR, and ,1.0 mg normal response (Schulze et al. Resp Med 2009). Well-controlled asthma (≥20 in Asthma Control Test) was found in 68% of children (,18 years) and 75% of adults (≥18 years). All subjects answered questions on asthma symptoms.. Moderate-severe BHR was found in 61% of children and 44% of adults. FeNO increased with more severe BHR in both children and adults, with a higher explanatory value in children (R2=0.15 vs 0.06). Well-controlled asthma was less prevalent in the moderate-severe BHR ...
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in International Journal of Clinical Practice (2012), 66(2), 158-65. Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of ... [more ▼]. Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50) ) remains a controversial diagnostic tool. Aim: To assess the ability of FE(NO50) to identify bronchial hyperresponsiveness (BHR) to methacholine (provocative concentration of methacholine causing a 20% fall in FEV(1) ; PC20M ,/= 16 mg/ml) and to establish whether or not symptoms relate to FE(NO50) and PC20M in patients with no demonstrated reversibility to beta(2) -agonist. Methods: We conducted a prospective study on 174 steroid naive patients with respiratory symptoms, forced expiratory ...
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