TY - JOUR. T1 - Methacholine inhalation challenge studies in a selcted pediatric population. AU - Hopp, R. J.. AU - Bewtra, A. K.. AU - Nair, N. M.. AU - Watt, G. D.. AU - Townley, R. G.. PY - 1986. Y1 - 1986. N2 - To determine bronchial reactivity patterns, 400 subjects, 5 to 21 yr of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or allergy was based on a respiratory questionnaire. Subjects were nonsmokers and had had no respiratory infections for 1 month. Intradermal skin tests were done. The methacholine challenge response was expressed as the area beneath the dose-response curve (Area35). Fifty-five asthmatics, 113 normal subjects from normal families, 103 normal subjects from asthma families, 60 normal twins, and 69 allergic subjects without asthma were studied. Overall, 52% of nonasthmatics and 47% of nonallergic subjects had an Area35 less than 4,000 (800 breath units). There was a difference (p , 0.05) in the distribution of ...
Rationale: Methacholine and mannitol challenges are used clinically to assess airway hyperresponsiveness (AHR). Cough during (a) high-dose methacholine challenge in individuals with methacholine-induced cough and normal airway sensitivity and (b) mannitol challenge in some individuals with asthma both occur in the absence of significant declines in forced expiratory volume in one second (FEV1). We hypothesized mechanical responses to these challenges would reflect a continuum amongst subjects with: (i) asthma; (ii) cough variant asthma (CVA) and (iii) methacholine-induced cough and normal airway sensitivity due to varying degrees of impairment/preservation of the beneficial effects of deep inspirations. Purpose: To compare cough and airway responses to mannitol and high-dose methacholine challenges between these groups. Methods: Individuals with asthma or suspected CVA were invited to participate. Subjects were challenged with mannitol and high-dose methacholine in random order 2-14 days apart. ...
Methacholine Chloride: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
During the screening visit, subjectsvital signs (heart rate, blood pressure and temperature) will be measured and they will perform standard spirometry. If the results of this test are 70% of normal or greater, they will be examined by a physician, and blood (1 teaspoonful) and urine will be collected for routine laboratory tests (CBC and routine urinalysis). If they are a female, a pregnancy test will be performed.. During the second visit, subjects will inhale 1 or 2 doses of formoterol, (Foradil Aerolizer 12 mcg/capsule) a long-acting bronchodilator and 1 hour later, perform a methacholine test.. At the end of the methacholine test, they will be given albuterol to reverse the effects of methacholine. On the third study day, they will repeat the second visit but with the opposite dose of Foradil. ...
Dr. Anand responded: Methacholine test. The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results. Some times the answer may not be clear cut.
The results of these experiments in anaesthetised Brown Norway rats show that prolonged inhalation of methacholine results in a predominantly parenchymal (or tissue) constrictor response which is effectively reversed by a maximum dose of atropine sulphate but not by pirenzepine. In contrast, intravenous methacholine produced more marked changes in airway resistance which were reversed by pirenzepine.. Our adaptation of the low frequency forced oscillation technique allows lung mechanics to be partitioned into airway and parenchymal components by fitting the constant phase model to the impedance spectra. The airways through which gas moves by bulk flow will be included in the airway component, whereas airways through which gas moves by diffusion are likely to be included in the parenchymal component. It is therefore most likely that the parenchymal response is the result of contraction of smooth muscle in respiratory bronchioles and alveolar ducts and of contractile elements in the alveolar ...
The 547 asymptomatic subjects with normal pulmonary function were grouped according to quintile of prechallenge FEV, (percent predicted), and the fifth percentiles of PD20FEV, within each quintile of FEV, were calculated (Table 2). The fifth percentile of methacholine PD20FEV, increased with increasing quintile of prechallenge FEV,. This relationship is shown graphically in Figure 1, in which the fifth percentile of PD20FEV, for each quintile is plotted against the median FEV, for that quintile. Restricting analysis to a subgroup of 157 lifetime nonsmokers yielded similar values for the fifth percentiles of PD20FEV,, for both overall and FEV,-specific percentiles (data not shown). canadian health & care mall. The overall fifth percentile of PD20FEV, (8.3 (imol) and the FEV,-specific fifth percentiles of PD20FEV, (as indicated in Table 2) respectively defined the 26 (4.8 percent) and 27 (4.9 percent) most responsive subjects among the 547 asymptomatic men. Seventeen (3.1 percent) men were ...
Wheezing during infancy has been linked to early loss of pulmonary function. We prospectively investigated the relation between bronchial hyperresponsiveness (BHR) and progressive impairment of pulmonary function in a cohort of asthmatic infants followed until age 9 years. We studied 129 infants who had had at least three episodes of wheezing. Physical examinations, baseline lung function tests and methacholine challenge tests were scheduled at ages 16 months and 5, 7 and 9 years. Eighty-three children completed follow-up. Twenty-four (29%) infants had wheezing that persisted at 9 years of age. Clinical outcome at age 9 years was significantly predicted by symptoms at 5 years of age and by parental atopy. Specific airway resistance (sRaw) was altered in persistent wheezers as early as 5 years of age, and did not change thereafter. Ninety-five per cent of the children still responded to methacholine at the end of follow-up. The degree of BHR at 9 years was significantly related to current clinical status
A number of mechanisms have been proposed as the basis for the relationship between nonspecific airway responsiveness and prechallenge pulmonary function. Because resistance to flow through a tube is inversely proportional to the radius to the fourth power, a given degree of bronchoconstrictor-induced circumferential airway narrowing can be expected to cause a proportionally larger increase in airway resistance in a narrow airway than in a wider airway. Intersubject differences in the distribution of resistance along the bronchial tree may influence both the pattern of aerosol deposition and the relative impact on total airway resistance of bronchoconstriction at particular sites such as the peripheral airways. Airway hyperresponsiveness may result in heightened bronchomotor tone prior to challenge and thereby be correlated with reduced prechallenge pulmonary function. The convention of expressing responsiveness in terms of percentage of change in FEV, (eg, PD20FEV,) imposes a mathematical ...
Since in the model used in this study all the Newtonian resistive and inertial properties are represented by Raw and Iaw , respectively, the inferences to central and peripheral airway responses are not straightforward. However, the significant increase in Iaw at PCFEV0.5 provides indirect evidence that Mch evoked significant constriction in the nasal and central airways. In addition, nine infants had a significant positive response in Iaw as defined by an increase of ,2 SD units. The inertance of the nasal passages contributes most of the total inertance of the respiratory system,16 making this parameter highly sensitive to changes in the properties of the extrathoracic airways. This response of both the central and peripheral airways to inhaled Mch has also been shown in asymptomatic adults by Ohrui et al 17 using a catheter tipped manometer lodged in a bronchus of 3 mm inner diameter. The response in Iaw in the present study indicates a response in the nasal and/or central pathways. Such a ...
Smiths Medical Asthma Patient Testing Kit (Methacholine Bronchoprovocation) is a convenient, all-inclusive procedural kit for the assessment of the respiratory
1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline.. 2. After urea ventilatory capacity was impaired in 68% of subjects and improved in 16%. This response was a relatively constant phenomenon in the same subject. Urea appears to possess the unusual property of being able to produce both bronchoconstriction and bronchodilatation. The response could not be related to any of the clinical or other physiological variables examined.. 3. Mild hypoxaemia, ventilation-blood-flow inequality and impairment of gas transfer also occurred after urea administration.. 4. Methacholine produced considerable impairment of ventilatory capacity with consistent hyperinflation but with variable changes in ventilatory pattern and distribution of ventilation.. 5. Isoprenaline rapidly and completely reversed ...
Dose-response curves to methacholine were examined in 9 normal and 10 asthmatic volunteers to determine whether the relationship between dose and response can be adequately summarized by means of a single, continuous measure that is not censored at lower levels of bronchial responsiveness. Subjects …
Detailed dosage guidelines and administration information for Provocholine (methacholine chloride). Includes dose adjustments, warnings and precautions.
TY - JOUR. T1 - Assessment of bronchial responsiveness following exposure to inhaled occupational and environmental agents. AU - Currie, G. P.. AU - Ayres, Jonathan Geoffrey. PY - 2004. Y1 - 2004. M3 - Article. VL - 23. SP - 75. EP - 81. JO - Toxicology. JF - Toxicology. SN - 0300-483X. ER - ...
Methacholine tests are widely used as a diagnostic aid for asthma. Their strength has been reputed to be the high sensitivity and very infrequent occurrence of ...
Background : An increase in asthma prevalence (or asthma-like symptoms) has been established in obese subjects, especially women. The aim of this pathophysiological study is to evaluate whether the modifications of respiratory mechanics due to severe obesity (Body Mass Index [BMI],35) may explain the increase in asthma prevalence. Our hypothesis is that a decrease in variability of tidal breathing (evaluated by the coefficient of variation of Tidal volume: CVTV) (which traduces a physiological response to the increased work of breathing) associated with a decrease in the frequency of deep inhalations (FDI) (physiological sighs). The bronchodilatory and bronchoprotective roles of these deep inhalations have been demonstrated. The avoidance of deep inhalations during 10 minutes in healthy subjects is responsible for a non specific transient airway hyperresponsiveness (AHR) to methacholine. Consequently, obesity-related asthma could be due to the loss of bronchoprotective effect of deep ...
Club cell secretory protein (CC-16) is a sensitive biomarker of airways epithelium integrity. It has gained interest as a biological marker in chronic lung diseases because of its presumed relationship to inflammation. Little is known about the association between CC-16 serum level and asthma, lung function and airway responsiveness (AR). Serum CC-16 level was determined by latex immunoassay in 1298 participants from the French Epidemiological case-control and family-based study on Genetics and Environment of Asthma (EGEA) (mean age 43 years; 49% men, 38% with asthma). Pre-bronchodilator lung function (forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC) and FEV1 /FVC) and degree of AR, expressed as a function of the dose-response slope to methacholine test were measured. Standardized residuals CC-16 z-scores were obtained by regressing CC-16 level on the glomerular filtration rate. CC-16 z-scores were correlated with asthma, lung function and AR in participants with and without asthma.
Bronchial hyperresponsiveness (BHR) is a hallmark of asthma. BHR to methacholine is used for diagnosis, but the role in monitoring treated asthma is not established. In the present study we assessed the relation between BHR to methacholine, airways inflammation, asthma control and symptoms.. Methacholine challenge and FeNO measurements were done in 371 asthmatics (aged 10-35 years) with inhaled corticosteroids prescribed. PD20 ,0.3 mg defined moderate-severe BHR, 0.3 to 1.0 mg borderline-mild BHR, and ,1.0 mg normal response (Schulze et al. Resp Med 2009). Well-controlled asthma (≥20 in Asthma Control Test) was found in 68% of children (,18 years) and 75% of adults (≥18 years). All subjects answered questions on asthma symptoms.. Moderate-severe BHR was found in 61% of children and 44% of adults. FeNO increased with more severe BHR in both children and adults, with a higher explanatory value in children (R2=0.15 vs 0.06). Well-controlled asthma was less prevalent in the moderate-severe BHR ...
The effectiveness of strategies for treatment of the altered static lung volume and against the development of bronchial hyperreactivity (BHR) following a left ventricular dysfunction (LVD) induced by myocardial ischaemia was investigated in a rat model of sustained postcapillary pulmonary hypertension. Airway resistance (Raw) was identified from the respiratory system input impedance (Zrs) in four groups of rats. End-expiratory lung volume (EELV) was determined plethysmographically, and Zrs was measured under baseline conditions and following iv infusions of 2, 6 or 18 μg/kg/min methacholine. Sham surgery was performed in the rats in Group C, while the left interventricular coronary artery was ligated and Zrs and its changes following identical methacholine challenges were reassessed in the same rats 8 weeks later, during which no treatment was applied (Group I), or the animals were treated daily with a combination of an angiotensin enzyme converter inhibitor and a diuretic (enalapril and furosemide,
The IUPHAR/BPS Guide to Pharmacology. methacholine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Our study investigated if airway hyperresponsiveness (AHR) at asthma onset could predict FEV1 decline in treated asthmatics. We retrospectively recruited 275 subjects that had performed a methacholine test at asthma onset and FEV1 measurements after 5-10 years. We subdivided subjects into three groups, according to their AHR level. 65 patents had normal reactivity (25 males; mean age 46±15; mean baseline FEV1%:96.1±20); 78 were borderline/mild AHR (PD20,400µg) (26 males; mean age 43±14; mean baseline FEV1%:102±12; mean PD20:1120±696) and 132 showed moderate/severe AHR (PD20≤400µg; 51 males; mean age 43±14; mean baseline FEV1%: 94±13; mean PD20:185±108). Annual FEV1 declines (the differences between the first and last measurements, divided by the number of years separating them) were compared. Average annual FEV1 declines (after 7±2 years) were similar in all groups: 46.2±81 ml/yr in normal reactivity subjects, 53±65 in borderline/mild AHR and 45±62.5 in moderate/severe AHR ...
in International Journal of Clinical Practice (2012), 66(2), 158-65. Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of ... [more ▼]. Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50) ) remains a controversial diagnostic tool. Aim: To assess the ability of FE(NO50) to identify bronchial hyperresponsiveness (BHR) to methacholine (provocative concentration of methacholine causing a 20% fall in FEV(1) ; PC20M ,/= 16 mg/ml) and to establish whether or not symptoms relate to FE(NO50) and PC20M in patients with no demonstrated reversibility to beta(2) -agonist. Methods: We conducted a prospective study on 174 steroid naive patients with respiratory symptoms, forced expiratory ...
No significant alterations in airway reactivity were observed at one or seven days after exposure either in baseline values or following methacholine (MCh) inhalation challenge. Although there was a trend for an increase in lung neutrophils and phagocyte oxidant production at one-day post exposure, there were no significant differences in parameters of lung inflammation. In addition, increased blood monocytes and neutrophils, and decreased lymphocyte numbers at one-day post exposure also did not differ significantly from air controls, and no alterations in splenocyte populations, or serum or spleen immunoglobulin M (IgM) to antigen were observed. There were no significant differences in peripheral vascular responsiveness to vasoconstrictor and vasodilator agonists or in blood pressure (BP) responses to these agents; however, the baseline heart rate (HR) and HR responses to isoproterenol (ISO) were significantly elevated at one-day post exposure, with resolution by day 7 ...
Modulating response among children with atopic asthma:29 In this study published in the International Journal of Food Sciences and Nutrition, 11 children (six girls and five boys) underwent a spirometry, methacholine provocation testing and blood testing for serum IgE lymphocyte glutathione (GSH) before and after a month of taking a whey-based oral supplement (a 10-gram dose taken twice a day).. The researchers chose to examine the effects of a whey-based oral supplement among children with atopic asthma because it is a T-helper type 2 (Th2) cytokine disease, and supplementation is said to help improve lung function and decrease atopy. Initially, the researchers discovered that GSH levels in antigen-presenting cells promoted a Th2 cytokine response in mice.. Results showed a decrease in IgE levels after supplementation, but there were no significant changes in lymphocyte GSH or baseline forced expired volume in 1 second (FEV1) levels for the group as a whole.. Based on this study, whey protein ...
.. In an inhalation challenge with methacholine (a drug that stimulates secretions and smooth muscle activity) and leukotriene D4, the fluticasone propionate therapy vs. placebo for two weeks caused a significant improvement (reduction) in methacholine sensitivity (a measure of airway hyper-responsiveness) and in exhaled nitric oxide 5HT1 agonist (Triptans) and Intranasal Migraine Medications - and…
TY - JOUR. T1 - Airway hyperresponsiveness. T2 - From molecules to bedside. AU - Sieck, Gary C. PY - 2003/7/1. Y1 - 2003/7/1. UR - http://www.scopus.com/inward/record.url?scp=0038309533&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0038309533&partnerID=8YFLogxK. M3 - Article. C2 - 12794089. AN - SCOPUS:0038309533. VL - 95. SP - 1. EP - 2. JO - Journal of Applied Physiology. JF - Journal of Applied Physiology. SN - 8750-7587. IS - 1. ER - ...
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2016 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 121, no 3, p. 198-198Article in journal, Letter (Refereed) Published ...
Addressing the issue of whether to grant a second inter partes review (IPR) after all of the claims had previously been adjudicated, the Patent Trial…
Bronchial hyperresponsiveness (or other combinations with airway or hyperreactivity) is a state characterised by easily triggered bronchospasm (contraction of the bronchioles or small airways). Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease (COPD). In the Lung Health Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors. In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. Bronchial hyperresponsiveness has been associated with gas cooking among subjects ...
My humble answer: There really is no difinitive test to diagnose asthma. However, the methacholine challenge is a pretty significant indicator. If you have a negative methacholine challenge chances are you dont have asthma. The reason I can say this is because if you have asthma the challenge will make you short of breath, and a bronchodilator breathing treatment will make you feel better. If none of these happen, chances are you dont have asthma. A second opinion is always a good idea, however. ...
Bronchial hyperresponsiveness (or other combinations with airway or hyperreactivity) is a state characterised by easily triggered bronchospasm (contraction of the bronchioles or small airways).. Bronchial hyperresponsiveness can be assessed with a bronchial challenge test. This most often uses products like methacholine or histamine. These chemicals trigger bronchospasm in normal individuals as well, but people with bronchial hyperresponsiveness have a lower threshold.. Bronchial hyperresponsiveness is a hallmark of asthma but also occurs frequently in people suffering from chronic obstructive pulmonary disease (COPD). In the Lung Heart Study, bronchial hyperresponsiveness was present in approximately two-thirds of patients with non-severe COPD, and this predicted lung function decline independently of other factors. In asthma it tends to be reversible with bronchodilator therapy, while this is not the case in COPD. ...
Rationale Roflumilast is an investigational PDE4 inhibitor for potential asthma therapy. Inhibitory effects of roflumilast on allergen-induced early airway response (EAR), late airway hyperresponsiveness (AHR), and inflammatory cells were investigated in a fungal allergen model of asthma in BALB/c mice. Methods Mice were sensitized with Aspergillus fumigatus extract (Afu) and adjuvant (i.p. and s.c. both on Day 0). After 2 inhalation boosts with Afu aerosol on Days 14 and 21, animals were Afu aerosol challenged on Day 23. Before each Afu aerosol exposure, animals received i.g. 1mg/kg or 5mg/kg roflumilast. For EAR, lung resistance was measured by body plethysmography in orotracheally intubated mice. AHR against aerosolized methacholine was determined 24 h after challenge by head-out plethysmography. Bronchoalveolar lavage (BAL) was done 25 h after challenge and differential cell count was determined. Results Afu-sensitized and -challenged mice showed pronounced EAR, AHR, and pulmonary ...
Local Lung Function And Airway Size Response During Methacholine Challenge And Salbutamol Treatment Measured Using High-Resolution Dynamic CT And Functional Lung Imaging
Sensitization to latex proteins can cause immediate IgE mast cell-mediated reactions. Health care workers have been found to be particularly at risk because of high exposure. Latex allergy can be produced in mice as demonstrated by IgE and eosinophil responses. Thus the mouse is a potential animal model for studying this disease, but the airway response to latex sensitization in mice has not been evaluated previously. In the present study, we immunized BALB/c mice intranasally with nonammoniated latex proteins. Animals were anesthetized, and lung mechanics were evaluated plethysmographically. Changes in pulmonary conductance (GL) and compliance (Cdyn) were measured in response to a nonspecific challenge with methacholine or to a direct challenge with intravenous latex antigen. Latex sensitization resulted in elevated levels of IgE and latex-specific IgG1 as well as interstitial infiltrates consistent with an allergic response. The methacholine dose-response ED50 for GL was 116.4 μg for the control mice
Nonspecific bronchial hyperreactivity (BHR) has been reported to occur in patients with bronchiectasis. To evaluate this further, we studied 77 patients with stable bronchiectasis (noncystic fibrosis) with special reference to the prevalence of BHR to methacholine (MCh), and its relation to lung function, sputum characteristics, concommitant asthma, and atopy. The concentration of MCh required to produce a fall of 20% in forced expiratory volume in 1 s (FEV 1), PC 20, was determined by Wrights nebulization tidal breathing method. BHR defined by a PC 20 ≤ 8 mg/ml was found in 21 of 47 (45%) subjects who underwent bronchial challenge. Presence of BHR was positively associated with low baseline spirometric values, diagnosis of asthma, long duration of disease, and elevated total IgE on univariant analysis, and was significantly related to FEV 1/forced vital capacity (FVC) ratio and asthma on multiple regression analysis. Ten of the 21 hyperreactive subjects did not have clinical asthma, whereas ...
Background: It is unclear why obesity is associated with worse asthma control. We hypothesized that(1) obesity affects asthma control independent of spirometry, airway inflammation, and airway hyperresponsiveness (AHR) and (2) residual symptoms after resolution of inflammation are due to obesity-related changes in lung mechanics. Methods: Forty-nine subjects with asthma underwent the following tests, before and after 3 months of high-dose inhaled corticosteroid (ICS) treatment: five-item asthma control questionnaire (ACQ-5), spirometry, fraction of exhaled nitric oxide (FENO), methacholine challenge, and the forced oscillation technique, which allows for the calculation of respiratory system resistance (Rrs) and respiratory system reactance (Xrs) as indicators of airway caliber and elastic load, respectively. The effects of treatment were assessed by BMI group (18.5-24.9, 25-29.9, and ≥30 kg/m 2 ) using analysis of variance. Multiple regression analyses determined the independent predictors of ACQ-5
TY - JOUR. T1 - Histamine forming capacity (HFC) and its modulation by H3 receptor ligands in a model of bronchial hyper-responsiveness. AU - Allen, Marcus. AU - Graham, P.. AU - Morris, G.. PY - 1996/3/1. Y1 - 1996/3/1. M3 - Article. VL - 45. SP - 118. EP - 122. JO - Inflammation Research. JF - Inflammation Research. SN - 1023-3830. IS - 3. ER - ...
BACKGROUND: Inhalation of swine house dust induces acute airway inflammation and increased bronchial responsiveness in healthy subjects. OBJECTIVE: The aim of the study was to investigate whether 5-lipoxygenase products such as leukotrienes may have a role in this reaction. METHODS: Twenty-three healthy subjects were randomised into two groups receiving treatment with either zileuton (600 mg) or placebo four times a day. After 5 days of treatment, all subjects were exposed for 3h in a swine barn. Bronchial responsiveness, exhaled nitric oxide (NO), and mediators in nasal lavage (NAL), blood and urine were measured before and after the exposure. RESULTS: The exposure induced an increased bronchial responsiveness to methacholine in both groups with 2-3 doubling concentration steps, no significant difference between treatments. Leukotriene E(4) in urine increased significantly following exposure in the placebo group from 37.3 (29.1-45.6) (mean (95% confidence interval)) ng/mmol creatinine to 47.7 ...
RATIONALE. Popcorn workers lung is a fixed obstructive pulmonary disease caused by inhalation of artificial butter flavoring during the manufacture of microwave popcorn. Previous investigations have implicated one of the components of butter flavoring, the -diketone flavoring, diacetyl, as an inhalation hazard in the workplace. Prior studies in rats demonstrated that inhalation of diacetyl vapo
P.H. Howarth, J.S. Mann, S.T. Holgate; The Influence of Resting Airway Calibre on Non-Specific and Specific Airway Reactivity in Asthma. Clin Sci (Lond) 1 January 1984; 67 (s9): 5P-6P. doi: https://doi.org/10.1042/cs067005Pb. Download citation file:. ...
To examine whether the development of hard metal (HM)-induced occupational asthma and interstitial lung disease involves alterations in nitric oxide (NO) pathways, we examined the effects of an industrial HM mixture on NO production, interactions between HM and lipopolysaccharide (LPS) on NO pathways, and alterations in airway reactivity to methacholine in rat lungs. HM (2.5 to 5 mg/100 g intratra
It is not appropriate for Drs Kaplan and Stanbrook to suggest that physicians who do not use spirometry should not manage patients with asthma.1 Such comments do not provide constructive guidance about clinical management and might serve to challenge the central role of family physicians in asthma care. Interestingly, it appears that Kaplan and Stanbrook are now supporting my side of the debate. They state that "empiric treatment of presumed asthma is acceptable only if followed by objective measurements of lung function to confirm clinical suspicion." This position seems very similar to my suggestion to treat and refer for methacholine challenge testing, as this approach will identify most patients with suspected asthma.2. My colleagues appropriately highlight that a single spirometry test might not always be successful in diagnosing or ruling out asthma definitively, but they offer no practical strategy for how physicians should manage patients with suspected asthma but normal spirometry ...
35-year-old female just diagnosed by methacholine challenge (21 and 23% on first dose). Symptoms of asthma for over 20 years. Self-treated with Primatene Mist and Ephedra. Just prescribed Advair 250/50...
Asthma, Rhinitis, Risk, Population, Adults, Allergy, Association, Bronchi, Mite, Nose, Risk Factor, Risks, Classification, Electrodiagnosis, Syndrome, Adult, Bronchial Hyperreactivity, Children, Methacholine, Odds Ratio
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... Archivio pubblicazioni 2019-2019. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine. Mani massaggio prostatico russo iperplasia di VC, cura per il mese della prostata come C est l infection, aiguë ou chronique, de la prostate (glande. Qual è il massaggio prostatico BPH prostata Calcinate, orchiectomia per ho fatto pipì e pyknotic B cells of the acinar nodule have a pale, eosinophilic cytoplasm. were generated with fluorescent tagged proteins at the C-terminus of P2X4R..
Bronchial challenge tests are used to evaluate bronchial responsiveness in diagnosis and follow-up of asthmatic patients. Challenge induced cough has increasingly been recognized as a valuable diagnostic tool. Various stimuli and protocols have been employed. The aim of this study was to compare cough and dyspnea intensity induced by different stimuli. Twenty asthmatic patients underwent challenge tests with methacholine, bradykinin and exercise. Cough was counted during challenge tests. Dyspnea was assessed by modified Borg scale and visual analogue scale. Statistical comparisons were performed by linear mixed-effects model. For cough evaluation, bradykinin was the most potent trigger (p | 0.01). In terms of dyspnea measured by Borg scale, there were no differences among stimuli (p | 0.05). By visual analogue scale, bradykinin induced more dyspnea than other stimuli (p ≤ 0.04). Bradykinin seems to be the most suitable stimulus for bronchial challenge tests intended for measuring cough in association
Molecular profiling of exhaled volatile organic compounds (VOC) by electronic nose technology provides breathprints that discriminate between patients with different inflammatory airway diseases, such as asthma and COPD. However, it is unknown whether this is determined by differences in airway caliber. We hypothesized that breathprints obtained by electronic nose are independent of acute changes in airway caliber in asthma. Ten patients with stable asthma underwent methacholine provocation (Visit 1) and sham challenge with isotonic saline (Visit 2). At Visit 1, exhaled air was repetitively collected pre-challenge, after reaching the provocative concentration (PC20) causing 20% fall in forced expiratory volume in 1 second (FEV1) and after subsequent salbutamol inhalation. At Visit 2, breath was collected pre-challenge, post-saline and post-salbutamol. At each occasion, an expiratory vital capacity was collected after 5 min of tidal breathing through an inspiratory VOC-filter in a Tedlar bag and sampled