TY - JOUR. T1 - Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barretts esophagus. AU - Kuester, Doerthe. AU - El-Rifai, Wael. AU - Peng, Dun Fa. AU - Ruemmele, Petra. AU - Kroeckel, Ivonne. AU - Peters, Brigitte. AU - Moskaluk, Christopher A.. AU - Stolte, Manfred. AU - Mönkemüller, Klaus. AU - Meyer, Frank. AU - Schulz, Hans Ulrich. AU - Hartmann, Arndt. AU - Roessner, Albert. AU - Schneider-Stock, Regine. N1 - Funding Information: This study was supported in part by financial support for a Spitzenbonusprojekt of the Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany (institutional grant to the Department of Pathology, Magdeburg) and by the National Cancer Institute Grant R01CA106176 (WER). The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute, Vanderbilt University or University of Magdeburg. The authors thank ...

TY - JOUR. T1 - Mucinous metaplasia of the prepuce - A case report and review of literature - A case report. AU - Mathew, Mary. AU - Joshi, Anurag. AU - Roy, Alfred. PY - 2006/4/1. Y1 - 2006/4/1. N2 - Benign mutinous metaplasia of the prepuce is a rare and under recognized entity which can easily be mistaken for extramammary Pagets disease. It is characterized by the presence of benign mucin containing cells in the squamous epithelium. To the best of our knowledge only 6 such cases have been documented in the literature. We would like to report the first case in our country.. AB - Benign mutinous metaplasia of the prepuce is a rare and under recognized entity which can easily be mistaken for extramammary Pagets disease. It is characterized by the presence of benign mucin containing cells in the squamous epithelium. To the best of our knowledge only 6 such cases have been documented in the literature. We would like to report the first case in our country.. UR - ...

TY - JOUR. T1 - Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. AU - Crawford, Howard C.. AU - Scoggins, Charles R.. AU - Kay Washington, M.. AU - Matrisian, Lynn M.. AU - Leach, Steven D.. PY - 2002. Y1 - 2002. N2 - In gastrointestinal epithelium, metaplastic conversion between predominant cell types is associated with an increased risk of neoplasia. However, the mechanisms regulating metaplastic transitions in adult epithelia are largely undefined. Here we show that matrix metalloproteinase-7 (MMP-7) is expressed not only in the majority of human pancreatic ductal adenocarcinoma specimens, but also in human pancreatic intraepithelial neoplasia and metaplastic duct lesions in human and mouse. In a mouse model of pancreatic acinar-to-ductal metaplasia, MMP-7 progressively accumulates during the metaplastic transition, resulting in a concomitant increase in solubilization of Fas ligand (FasL). Under identical ...

Carnivorous reptiles are not usually thought of as being prone to metabolic bone disorders. A constant diet lacking in calcium or bone and/or high in phosphorus or low in vitamin D3 can lead to this nutritional disorder in certain situations. Nile monitor lizards are carnivorous lizards native to Africa and common in the pet trade and as display animals in zoos. They normally consume whole vertebrate prey but will readily take muscle and organ offerings. This is a case of a Nile monitor that suffered fibrous osteodystrophy and chondroid metaplasia after being fed mostly muscle tissue for over two years. Once the diet was corrected the clinical signs resolved.. ...

AIM: To determine associations between enterogastric bile reflux and gastric mucosal pathology. METHOD: A retrospective study using fasting gastric juice bile acid measurements and antral or prestomal biopsy specimens from 350 patients, 66 of whom had previously undergone surgery that either bypassed or disrupted the pyloric sphincter. RESULTS: Bile reflux was positively associated with reactive gastritis and negatively with Helicobacter pylori density. After stratification for previous surgery, age, and H pylori status, the histological feature most strongly associated with bile reflux was intestinal metaplasia, including all its subtypes. The prevalence of intestinal metaplasia was greatest in patients with both H pylori infection and high bile acid concentrations. Bile reflux was also positively associated with the severity of glandular atrophy, chronic inflammation, lamina propria oedema and foveolar hyperplasia. CONCLUSIONS: Bile reflux is a cause of reactive gastritis. It modifies the ...

TY - JOUR. T1 - Coexistence of gastric- and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach. AU - Otsuka, Takafumi. AU - Tsukamoto, Tetsuya. AU - Mizoshita, Tsutomu. AU - Inada, Ken Ichi. AU - Takenaka, Yoshiharu. AU - Kato, Sosuke. AU - Yamamura, Yoshitaka. AU - Miki, Kazumasa. AU - Tatematsu, Masae. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Intestinal metaplasia (IM) in the human stomach has previously been classified into a gastric and intestinal mixed (GI-IM) and a solely intestinal phenotype (I-IM). The phenotypes of mucous and endocrine cells were evaluated in 3034 glandular ducts associated with chronic gastritis. In the pyloric region, the relative expression of gastric endocrine cell markers, such as gastrin and somatostatin, decreased gradually from glandular ducts with only gastric mucous cell phenotype (G type) to GI-IM toward I-IM, while that of the intestinal endocrine cell markers, glicentin, gastric inhibitory polypeptide (GIP), ...

Background Surveillance of premalignant gastric lesions relies mainly on random biopsy sampling. Narrow band imaging (NBI) may enhance the accuracy of endoscopic surveillance of intestinal metaplasia (IM) and dysplasia.We aimed to compare the yield of NBI to white light endoscopy (WLE) in the survei …

Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by environmental stimuli, which may act in concert with the deleterious effects of microorganisms and inflammation. The cell of origin for intestinal metaplasia in the oesophagus and stomach and for pancreatic acinar-ductal metaplasia has been posited through genetic mouse models and lineage tracing but has not been identified in other types of metaplasia, such as squamous metaplasia. A hallmark of metaplasia is a change in cellular identity, and this process can be regulated by transcription factors that initiate and/or maintain cellular identity, perhaps in concert with epigenetic reprogramming. Universally, metaplasia is a precursor to low-grade dysplasia, which can culminate in high-grade dysplasia and carcinoma. Improved clinical screening for and surveillance of metaplasia might lead to better prevention or early ...

Danahay, Henry and Pessotti, Angelica and Coote, Julie and Montgomery, Brooke and Xia, Donghui and Wilson, Aaron and Yang, Haidi and Wang, Zhao and Bevan, Luke and Thomas, Chris and Petit, Stephanie and London, Anne and Lemotte, Peter and Doelemeyer, Arno and Velez-Reyes, German and Bernasconi, Paula and Fryer, Christy and Edwards, Matthew and Capodieci, Paola and Chen, Amy and Hild, Marc and Jaffe, Aron (2015) Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Reports. ...

The molecular pathogenesis of Barretts metaplasia (BM) of the esophagus is poorly understood. The change to an intestinal phenotype occurs on a background of esophagitis due to refluxing acid and bile. CDX1, an important regulator of normal intestinal development, was studied as a potential key molecule in the pathogenesis of BM. CDX1 mRNA and protein were universally expressed in all samples of BM tested but not in normal esophageal squamous or gastric body epithelia. This tissue-specific expression was attributable to the methylation status of the CDX1 promoter. Conjugated bile salts and the inflammatory cytokines TNF-alpha and IL-1beta were all found to increase CDX1 mRNA expression in vitro. These effects were primarily mediated by NF-kappaB signaling but only occurred when the CDX1 promoter was unmethylated or partially methylated. The data suggest that CDX1 is a key molecule linking etiological agents of BM to the development of an intestinal phenotype. Although the initial trigger for CDX1

ORCID: 0000-0003-2130-9181, Provenzale, Dawn and Moayyedi, Paul (2002) Esophageal adenocarcinoma arising from Barretts metaplasia has regional variations in the west. Gastroenterology, 122 (2). pp. 588-590. ISSN 0016-5085 Full text not available from this repository.. Official URL: http://dx.doi.org/10.1053/gast.2002.31599. ...

In this study, we aimed to investigate the characteristics of the duodenal mucosal microbiota of patients with intestinal metaplasia (IM) and compare it with those of the gastric mucosal microbiota. We collected the duodenal and gastric mucosal samples from 10 adult patients with IM and 10 healthy controls (HC). The V3-V4 region of the bacterial 16S rRNA gene was examined by high throughput sequencing method. The diversity of the HC duodenal microbiota was higher than that of IM patient based on the Shannon and Simpson index while the Chao indices of IM duodenal mucosal microbiota was significantly higher than that of gastric mucosal microbiota of patients with IM. There was a marked difference in the duodenal microbiota structure between patients with IM and HC (ANOSIM, R = 1, P = 0.001). We also found that the Helicobacter pylori infection in gastric mucosa did not influence the structure of duodenal mucosal microbiota. The gastric mucosal microbiota structure significantly differed between patients

TY - JOUR. T1 - Expression of small intestinal and colonic phenotypes in complete intestinal metaplasia of the human stomach. AU - Tanaka, Harunari. AU - Tsukamoto, Tetsuya. AU - Mizoshita, Tsutomu. AU - Inada, Ken Ichi. AU - Ogasawara, Naotaka. AU - Cao, Xueyuan. AU - Kato, Sosuke. AU - Joh, Takashi. AU - Tatematsu, Masae. N1 - Funding Information: Acknowledgements This study was supported in part by a Grant-in-Aid for the Third-term Comprehensive 10-year Strategy for Cancer Control and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare, Japan, and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors thank Dr. Malcolm A. Moore for revision of the scientific English language and Ms. Hisayo Ban for expert technical assistance. The anti-sucrase antibody was a generous gift from Dr. Kazuyuki Hirano, Department of Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.. PY - 2005/11. Y1 - 2005/11. N2 - The ...

TY - JOUR. T1 - A longitudinal study of the JAK2V617F mutation in myelofibrosis with myeloid metaplasia. T2 - Analysis at two time points. AU - Mesa, Ruben A.. AU - Powell, Heather. AU - Lasho, Terra. AU - DeWald, Goron W.. AU - McClure, Rebecca. AU - Tefferi, Ayalew. PY - 2006/3/1. Y1 - 2006/3/1. N2 - Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.. AB - Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.. KW - ...

Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well as constitutive EGFR activation in cultured nasal epithelial cells from asthmatic subjects compared with nonasthmatic controls and in lung tissues of mice during house dust mite-induced (HDM-induced) allergic inflammation. EGFR activation was associated with cysteine oxidation within EGFR and the nonreceptor tyrosine kinase Src, and both amphiregulin production and oxidative EGFR activation were diminished by pharmacologic or genetic inhibition of the epithelial NADPH oxidase dual oxidase 1 (DUOX1). DUOX1 deficiency also attenuated several EGFR-dependent features of HDM-induced allergic airway inflammation, including neutrophilic inflammation, type 2 cytokine production (IL-33, IL-13), mucous metaplasia, ...

TY - JOUR. T1 - Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barretts Cells. AU - Zhang, Qiuyang. AU - Agoston, Agoston T.. AU - Pham, Thai H.. AU - Zhang, Wei. AU - Zhang, Xi. AU - Huo, Xiaofang. AU - Peng, Sui. AU - Bajpai, Manisha. AU - Das, Kiron. AU - Odze, Robert D.. AU - Spechler, Stuart J.. AU - Souza, Rhonda F.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background & Aims: Metaplastic glands buried under squamous epithelium are frequently detected in patients with Barrett esophagus (BE). This subsquamous intestinal metaplasia might be responsible for cancers that develop despite endoscopic surveillance and for metaplasia recurrences after endoscopic ablation. To determine whether reflux induces BE cells to undergo an epithelial-to-mesenchymal transition (EMT) that produces subsquamous intestinal metaplasia, we assessed EMT in BE cells exposed to acidic bile salts and in rat and human esophageal tissues. Methods: We compared markers of EMT ...

The first step in treatment is getting a diagnosis. Because Barretts esophagus doesnt lead to any noticeable symptoms, its more likely that the doctor will notice the condition while checking for a related acid reflux condition. To diagnose the condition, doctors do something called an endoscopy. This is essentially a procedure where the doctor will push a small, flexible camera down the esophagus to do a visual inspection of the damage.. The doctor will then take a small biopsy of tissue from the esophagus and examine the tissue under a microscope to see if metaplasia has occurred. Once youve got a diagnosis, there are a few ways to treat the condition.. The first step is to minimize the risk of cancer. This usually involves basic treatments for acid reflux and lifestyle changes to reduce risk. Things like smoking and alcohol use are not only a significant factor in acid reflux but can raise your risk of cancer. By making changes to these habits and your diet, you can help reduce the amount ...

Blood analysis revealed a leukocytosis (29370/mm3) with neutrophilia (23202/mm3). Low-dose dexamethasone test definitely excluded Cushing disease (basal cortisol levels 2,17 µg/dl; cortisol at 4 and 8 hours , 1 µg/dl). A prostatic wash was performed and revealed a severe prostatitis and presence of keratinized prostatic cells, indicating a squamous metaplasia of the prostate. Measurement of seric LH levels (LH Witness®, Synbiotics) showed an LH concentration lower than 1 ng/ml, indicating a hormonal negative feedback on the hypothalamo-hypophyso-gonadal axis ...

During the EGD, Barrett esophagus is diagnosed. Omeprazole is taken following the surgery. Without parietal cells, how does PPI work?(or some metaplastic cell have acid secreting function which can be suppressed by PPI?) Would EGD increase the risk of bile reflux and aggravate metaplasia?....:dead ...

Idiopathic generalized myelofibrosis with myeloid metaplasia is a disease of unknown etiology in which the clinical and morphologic manifestations vary greatly even during the course of an individual case. The resulting confusion has led to an undue number of synonyms, each of which tends to focus on a single aspect of the disease. Many cases exhibit panhyperplasia of all bone marrow elements including fibroblasts, although eventually the more characteristic picture of fibrosis may predominate. Myeloid metaplasia is a constant and persistent finding, even when the bone marrow is hypercellular. A leukoerythroblastic peripheral blood picture is usually present at some time ...

Male and female breeder rats spontaneously develop arteriosclerosis. This occurs first in the aorta and coronary arteries and subsequently in the carotid and intracranial arteries. The carotid arteries show mesenchymal cell proliferation in the media followed by subintimal swelling and mucoid deposition, elastosis, cartilaginous metaplasia and eventual bone formation. Lipid deposition occurs infrequently, and then only in advanced lesions in the media. Severe lesions are much more frequent in the female breeder and the tendency towards cartilaginous metaplasia and bone formation is peculiar to the carotid arteries. The cerebral arteries show little arteriosclerotic involvement except for aneurysm-like outpouchings of the internal elastic membrane associated with mucopolysaccha-ride accumulation about the sites of elastic tissue disruption. Despite severe fulminating arteriosclerosis in the carotid arteries, the cerebral arteries and the brain tissue itself show little or no significant evidence ...

Burgel, P., and Nadel, J. (2004). Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 59, 992-996.. Casalino-Matsuda, S., Monzón, M., and Forteza, R. (2006). Epidermal Growth Factor Receptor Activation by Epidermal Growth Factor Mediates Oxidant-Induced Goblet Cell Metaplasia in Human Airway Epithelium. Am J Respir Cell Mol Biol 34, 581-591.. Curran, D., and Cohn, L. (2010). Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease. Am J Respir Cell Mol Biol 42, 268-275.. Gao, W., Li, L., Wang, Y., Zhang, S., Adcock, I.M., Barnes, P.J., Huang, M., and Yao, X. (2015). Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease? Respirology 20, 722-729.. Hennessy, B.T., Smith, D.L., Ram, P.T., Lu, Y. and Mills, G.B., 2005. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4, 988-1004.. Øvrevik, ...

Confocal laser endomicroscopy (CLE) has been developed to overcome the limitations of the current endoscopic sampling techniques. CLE allows detailed examination of cellular structures since it provides images very similar to images which a pathologist can see in the microscope. At present, probe based CLE (pCLE) is the only available technology of endomicroscopy. Before optical biopsy, a fluorescein is given intravenously and then fluorescent light coming from a horizontal special focal plane is detected during pCLE of the digestive system.. CLE provide real-time histopathological diagnosis and can lead to an immediate endoscopic treatment in case of early esophageal and gastric neoplasia.. Patients after treatment of Barretts esophagus related esophageal neoplasia (dysplasia or early cancer) should be surveilled endoscopically with biopsies to rule out relapse of Barretts esophagus or neoplasia.. Project A - pCLE in the detection of esophageal and gastric lesions:. We plan to investigate the ...

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Supine duodeno-gastro-oesophageal bile reflux measured with the Bilitec-2000 appears to protect against the presence of microscopic intestinal metaplasia at the cardia Conference Paper ...

Published in the Journal of PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23308100 Abstract: We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, discount viagra of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to […]. ...

Numerous reviews and guidelines encourage us to undertake surveillance of patients with Barretts oesophagus (BO). Despite this, many experienced gastroenterologists consider there is insufficient evidence to support this approach. The definition of what constitutes BO remains an issue and is an important element of critically analysing reports. The previous idea that patients could be selected by the length of the Barrets segment (,3 cm) appears incorrect as it does not have a major influence on the subsequent risk of carcinoma.1 The presence of intestinal metaplasia (IM) is important in the pathogenesis of cancer development but the absolute requirement to identify an area of IM before making a diagnosis of BO appears irrational. This is because virtually all patients with a columnar lined oesophagus also have some IM if enough biopsies are taken.2. Depending on the definition, 0.25-2% of the general population have BO.3,4 The introduction of surveillance for this huge number would therefore ...

This suggests that the influx of inflammatory cells during the metaplasia to BE is not mainly caused by an inflammatory http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html process but in fact is the consequence of alterations due to the metaplastic tissue more resembling duodenal tissue. Further studies on the role of these ��intestinal�� lymphocytes in BE may result in a better understanding of the pathogenesis and/or prognosis of BE. Materials and Methods Patient characteristics Fifty-nine patients were included in our study. Of these, 41 patients had BE, as defined by the presence of specialised intestinal metaplasia (IM) containing goblet cells in at least one of the biopsies.. Eleven patients were excluded from the BE group due to the presence of macroscopic esophagitis (ulcers and erosions) proximal to the Barretts segment (n=1), BE segments being smaller then C0M2 because of the risk of biopsying squamous esophageal epithelium or gastric tissue instead of BE tissue ...

Synonyms for mucus cell in Free Thesaurus. Antonyms for mucus cell. 24 synonyms for cell: room, chamber, lock-up, compartment, cavity, cubicle, dungeon, stall, unit, group, section, core, nucleus, caucus, coterie, electric cell. What are synonyms for mucus cell?

Results The sample was mainly male (75%, n = 6,327) with median age of 64 years (range 18-92 years, n = 6,327). Median Barretts length was 4 cm (range 1-24 cm, n = 6,029) and median time since diagnosis of Barretts was 2 years (range 0-41 years, n = 5,805). At least one symptom of reflux was experienced by 60% of patients and 46% of patients experienced at least one symptom at least once per week (n = 1,072). Length of Barretts was associated with age (n = 6,029), gender (n = 6,029), presence of low grade dysplasia (n = 5,955), presence of intestinal metaplasia (n = 6,026) and time since diagnosis (n = 5,913). ...

TY - JOUR. T1 - LA LASER-CITOFLUORIMETRIA A FLUSSO NELLO STUDIO DELLE LESIONI INDOTTE DA PAPILLOMAVIRUS. AU - Altomare, G. F.. AU - Pigatto, P. D.. AU - Capella, G. L.. AU - Finzi, A. F.. PY - 1990. Y1 - 1990. N2 - HPV insertion into the genome can cause permanent changes in cellular DNA that disturb the regulation of cell proliferation. Most HPV-induced epithelial proliferative disease are benign, but not all. We have studied both types of lesion by automated laser flow cytometry to see if there were any permanent changes in the DNA that might serve as reliable prognostic indicators. There were 101 lesions of interest to the dermatologist, stomatologist and gynecologist. Although fluctuations in yields of cells make it difficult to formulate definite conclusions, since many results are heterogeneous and hard to summarize, we found dysplastic and metaplastic lesions always to be hyper- or hypodiploid and to our surprise two cases of common wart were hyperdisploid and another hypodiploid. This ...

Department of Biology and Biochemistry, University of Bath. Dr David Tosh leads the Vertebrate Embryonic Development research group at the Department of Biology and Biochemistry , University of Bath. His lab is interested in the phenomenon of transdifferentiation (sometimes referred to as metaplasia). Transdifferentiation is defined as the conversion of one differentiated cell type to another. It belongs to a wider class of cell type conversions known as metaplasias that include conversions between stem cell types.. The Tosh group has developed a number of models for the transdifferentiation of pancreas to liver and the reverse. They use their studies of transdifferentiation and metaplasia to help: ...

Over the past three to four decades, esophageal adenocarcinoma (EAC) incidence has increased dramatically in the Western world due to causes that are not well understood. Current screening strategies for early detection aim to identify individuals with Barretts esophagus (BE), an intestinal metaplasia that develops in the ...

We have examined the cell surface molecule CD44, which is attracting interest because of reports that isoforms are associated with metastasis. The prognostic value of CD44 expression has yet to be assessed for a solid tumour. Benign (59) and malignant (primary 61, metastatic 59) gastric tissues were examined with antibodies directed at epitopes common to known CD44 isoforms. Normal mucosa was CD44 negative. In atrophic gastritis and intestinal metaplasia expression was restricted to the epithelial cells of the basal glands and was positively correlated with an increased leucocyte infiltrate and with the expression of HLA DR by mucosal cells. These observations suggest a role for chronic inflammation in the induction of CD44 expression on benign mucosa. No such association was observed between inflammatory infiltrate and CD44 expression on gastric tumours. CD44 expression, observed in only 49% of primary tumours, was associated with distant metastases at time of diagnosis and, among 31 curatively ...

Tytu : Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barretts esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD ...

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Results The histological features include epithelial hyperplasia (21.1%), surface ulceration (2.2%), goblet cells (62.2%), squamous metaplasia (11.1%), active fibrosis (31.1%), severe inflammation (8.9%), multinucleated giant cells (3.3%), stromal calcification (8.9%) and active proliferating vessels (5.6%). Among these histological features, patients with either hyperplasia or calcification in their excised corneal pannus show an unfavourable outcome compared with patients without hyperplasia (p=0.003) or calcification (p=0.018). A similar unfavourable outcome was not seen with other histological features and various clinical parameters.. ...

Symptoms and treatment alternatives in cystitis, acute or chronic cystitis, interstitiel cystitis, squamous metaplasia, tuberculosis, nephritis

Precancerous lesions are areas of tissue with abnormally rapid cell growth. Though many precancerous lesions can be treated, if...

The standard treatment for patients with gastric low-grade dysplasia (LGD) remains controversial, even though diagnosis of LGD is increasingly common as esophagogastrodeuodenoscopy becomes more available. The aim of this study was to identify a lesio

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Biopsy specimens of gastric and duodenal mucosa from 290 patients were examined histologically for metaplasia and Campylobacter pyloridis. Estimates of pH on samples of fasting gastric juice from 55 of the patients were performed, and mucosal biopsy specimens from 33 patients were also cultured for C pyloridis. Active duodenitis was seen in 34 duodenal biopsy specimens. Thirty (88%) of the patients with active duodenitis had both greater than 5% gastric metaplasia in the duodenal specimen and C pyloridis associated gastritis. These two factors coexisted in only 0.43% of patients with no duodenal inflammation. When C pyloridis were seen histologically in duodenal biopsy specimens they were confined to areas of gastric metaplasia and never occurred in the absence of a polymorph infiltrate. Of the 55 patients with measurements of gastric juice pH, gastric metaplasia was present in the duodenum in 20 of 42 with a pH of less than 2.5, and in 0 of 13 with a pH of greater than 2.5. These results ...

Osseous metaplasia occurs outside the skeletal system in fibrodysplasia ossificans [13]. The incidental finding of bone in histological specimens, although extremely interesting, seems to have no clinical significance [8, 10]. Heterotopic ossification in colonic adenomas is a particularly rare phenomenon. There are only three other cases reported of ossification specifically in a tubular adenomas [7, 8, 12]. Osseous metaplasia can also occur in juvenile polyps [8], Peutz-Jeghers Syndrome [11] and inflammatory polyps [9] as well as in malignant lesions [1-6].. How this ectopic ossification occurs is unknown. It may be that the osteoblasts needed to lay down bone differentiate from fibroblasts or other precursor cells. Local osteogenic factors then stimulate these osteoblasts to incorporate collagen fibres already found at the site into new bone. Bone remodelling dependent on the balance between osteoblasts and osteoclasts occurs in areas of ectopic bone as it does in the normal skeleton ...

TY - JOUR. T1 - Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. AU - Nomura, Sachiyo. AU - Baxter, Tammy. AU - Yamaguchi, Hirokazu. AU - Leys, Charles. AU - Vartapetian, Andrey B.. AU - Fox, James G.. AU - Lee, Jeffrey R.. AU - Wang, Timothy C.. AU - Goldenring, James R.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2004/8. Y1 - 2004/8. N2 - Background & Aims: The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both rodent and human fundus. To examine the relationship of SPEM to the neoplastic process in the H. felis-infected C57BL/6 mouse, we have now studied the association of SPEM-related transcripts with preneoplasia. Methods: SPEM-related transcripts were identified by microarray ...

Gastric cancer is one of the most common neoplastic diseases in developed Western countries, and is characterized by a poor prognosis when diagnosed at a late stage [1]. Atrophic gastritis and gastric intestinal metaplasia (GIM) are well-known risk factors for the development of gastric cancer. For this reason, endoscopy with multiple biopsies is recommended in patients with atrophic gastritis or GIM, to exclude preneoplastic or neoplastic tissue [1]. Magnifying endoscopy with narrow band imaging (NBI) has been shown to be reliable for in vivo diagnosis of atrophic gastritis and GIM [1] [2] [3] [4]. However, while magnifying endoscopy is routinely used by Asian endoscopists, it is not established in most European and Northern American endoscopy centers. Recently, a novel endoscope with NBI and dual-focus capability has been introduced to improve the quality of endoscopic imaging [5]. Dual focus allows the user to select between two focus settings by pushing a button on the scope. This results in ...

Paratesticular liposarcoma is a rare tumour of the genitourinary track but the most common of all sarcomas in adults. The dedifferentiated variation occurs only in 10% of liposarcoma cases. The typical clinical presentation is similar to an inguinal hernia or a benign lipoma. We present the case of a dedifferentiated paratesticular liposarcoma with osseous metaplasia of the spermatic cord, in a male presented with acute scrotum.

TY - JOUR. T1 - Phase I trial-qualitative mapping of barrett metaplasia. T2 - A prrequisite for intervention trials. AU - Eisen, G. M.. AU - Montgomery, E. A.. AU - Azumi, N.. AU - Hartmann, D. P.. AU - Bhargava, P.. AU - Lippman, M.. AU - Benjamin, S. B.. PY - 1997. Y1 - 1997. N2 - Introduction: Barretts metaplasia (BM) is associated with a 30-125 fold higher risk of esophageal adenocarcinoma than the general population. BM may present as a cellular mosaic with irregular tongues of intestinal epithelia, varying areas of dysplasia and other intermediate markers for cancer risk. These areas may be missed on routine biopsy. If such areas cannot be readily relocated, chemopreventive studies will remain unfeasible. Methods: Utilizing a specially adapted upper gastroscope (Pentax Precision Instruments) that is able to accurately evaluate distance from incisors and endoscopic rotation, chromoendoscopy with toluidine blue and systematic mapping (4 quadrant jumbo biopsies at 1 cm intervals) was ...

Gastric atrophy and intestinal metaplasia are generally considered to be precancerous lesions of the stomach. Chronic Helicobacter pylori infection is one the most important factors in the development of these pre-malignant gastric lesions. In addition to bacterial factors, polymorphisms in the cytokine genes of the host that modulate inflammatory responses are found to have a synergistic effect in the development of gastric cancer as well as pre-neoplastic lesions. Recently, inappropriate activation of the intestine-specific transcription factor like the homeobox gene complex CDX1 and CDX2 are found to be an important contributing factor in the induction of intestinal metaplasia in the stomach. Aberrant expression of cyclooxygenase-2 and epigenetic changes are also frequently detected in pre-neoplastic gastric lesions. One of the most important questions relating to these pre-neoplastic gastric lesions is that whether H. pylori eradication could reverse these changes. However, most controlled ...

TY - JOUR. T1 - The value of traditional upper endoscopy as a diagnostic test for Barretts esophagus. AU - Wang, Amy. AU - Mattek, Nora C.. AU - Corless, Christopher. AU - Lieberman, David. AU - Eisen, Glenn M.. PY - 2008/11. Y1 - 2008/11. N2 - Background: The standard test for diagnosing Barretts esophagus (BE) is a conventional upper endoscopy. However, studies have shown that confirmation of BE by endoscopy with histologic intestinal metaplasia can be difficult. Objective: To determine the overall accuracy, as well as factors that influence the accuracy of a conventional upper endoscopy in diagnosing BE. Setting: Thirteen academic, community, and Veterans Affairs sites. Design: A retrospective data review. Patients: Patients who underwent an upper endoscopy with a finding of suspected Barretts esophagus and esophageal biopsies. Pathology reports were examined to identify cases with intestinal metaplasia. Main Outcome Measurements: Percentage of pathology-confirmed BE among suspected ...

Author: A. VASAHAR, V. KOTESWARY. Category: Pathology. [Download PDF]. Abstract:. Phyllodes tumor is a rare biphasic fibroepithelial neoplasm that comprises < 1% of all neoplasms of breast. A metaplastic changes in a phyllodes tumor, though reported, is an infrequently occurring event. Here we present a case of a 30-year-old female who presented with a breast lump. Histopathological examination revealed a benign phyllodes tumor with florid squamous metaplasia. This case is presented for its rarity.. Keywords: Phyllodes tumor, Squamous metaplasia, Keratin cyst. ...

We tested the hypothesis that MRI structural lesions in the SIJ, especially fat metaplasia, predict new bone formation on spinal radiographs from patients with axial SpA in a prospective cohort. This was aimed at addressing a key preliminary requirement in the validation of a surrogate MRI biomarker for radiographic progression in the spine of patients with SpA. Our multivariate data demonstrates that the presence of definite ankylosis in the SIJ at baseline (as defined by an SSS score of ≥2 by both readers), and its extent, is significantly associated with new bone formation on spinal radiography on follow-up. The degree of subchondral fat metaplasia in the SIJ is also independently associated with radiographic progression in the spine. The lack of any new bone formation in the spine despite prolonged symptom duration is associated with the absence of SIJ ankylosis and backfill. These data therefore support the hypothesis that structural lesions in the SIJ, specifically ankylosis and ...

Inclusion Criteria:. male or female and at least 18 years-of-age histologically confirmed diagnosis of myelofibrosis with myeloid metaplasia (MMM). This includes patients with agnogenic myeloid metaplasia (also known as idiopathic myelofibrosis) and patients with a preceding history of polycythemia vera or essential thrombocytemia (also known as post-polycytemic myelofibrosis). (see Appendix A) patients with low, intermediate and high risk disease categories (following the Dupriez score) may be included presence of measurable, clinically relevant disease manifestations (especially for low risk patients) ECOG performance status of 0, 1 or 2 life expectancy of at least 3 months Women of childbearing potential must use a medically acceptable form of contraception during the study and must have a negative urine or serum pregnancy test within 7 days of randomization written informed consent. Exclusion Criteria:. diseases associated with secondary myelofibrosis, such as metastatic carcinoma, lymphoma, ...

International Journal of Otolaryngology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of otolaryngology.

Gastric adenocarcinoma, like most other solid tumors, is thought to develop in a stepwise fashion. This pattern of carcinogenesis has been well described in the colon (24) and the pancreas (25), and will likely be described in greater detail in the stomach as well. As early as 1955, such a progression model was anticipated by Morson (2-4) who first described the transition from normal mucosa to intestinal metaplasia to gastric epithelial dysplasia to the development of gastric adenocarcinoma. More recently, distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer have been published (6), providing a framework for a gastric adenocarcinoma progression model. Our immunolabeling results are consistent with a progression model of gastric carcinogenesis insofar as the quantity (number of positive cases) and quality (intensity of labeling) generally increase from normal gastric mucosa to intestinal metaplasia to gastric epithelial dysplasia, primary cancers, and ...

Pyloric gland adenoma (PGA) is a rare neoplasm with gastric pyloric gland differentiation that is diagnosed most frequently in the stomach, but also occurs in the duodenum, esophagus, gallbladder, bile duct and rectum. In stomach it accounts for 2.7% of gastric polyps and develop in a background of chronic gastritis with intestinal metaplasia or atrophy, or both. Histologically, pyloric gland adenomas are composed of tightly packed tubules composed of pyloric gland type cells, which are cuboidal or columnar mucus-secreting cells with pale to moderately eosinophilic cytoplasm with absent apical mucin caps. Nuclei are small, round or ovoid, basally located, and often hyperchromatic. Histologically, cells resemble gastric pyloric gland epithelium and Brunner glands. PGA are divided into three categories: those without conventional histological dysplasia, low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Dysplasia is relatively common in pyloric gland adenomas, low- and high-grade dysplasia ...

CASTANO, Rodrigo et al. Preliminary Experience with Radiofrequency Ablation of Barretts Esophagus with in situ Dysplasia or Carcinoma. Rev Col Gastroenterol [online]. 2014, vol.29, n.4, pp.368-375. ISSN 0120-9957.. Introduction: Barretts esophagus (BE) is the result of chronic damage to the esophageal epithelium caused by the acid of gastrointestinal reflux diseases (GERD). It is defined as replacement of the by stratified squamous epithelium that normally lines the esophagus with metaplastic columnar epithelium. BE represents a risk factor for esophageal adenocarcinoma. The aim of radiofrequency ablation (RFA) is to destroy the metaplastic epithelium with the electric current of a radiofrequency to stimulate the reappearance of stratified squamous epithelium in the distal esophagus. Objective: The objective of this study was to evaluate the efficiency and safety of RFA which has recently been introduced in the city of Medellin, Colombia for management of BE with in situ dysplasia or ...

Preciado, D., Burgett, K., Ghimbovschi, S., Rose, M. (2013). NTHi induction of Cxcl2 and middle ear mucosal metaplasia in mice. Laryngoscope, 123(11), E66-E71.. ...

In a retrospective study performed in California, U.S.A., ca. 3% of patients with gastric intestinal metaplasia (GIM) developed gastric cancer (GC) within a median time period of 4.6 years after diagnosis of GIM. This observation stresses the importance of targeted surveillance even in regions with a low GC prevalence. Patients with alcoholic liver disease as well as survivors of colorectal and lobular breast cancer were found to be at increased risk of secondary GC. A population-based Chinese study confirmed serologic biopsy as a useful screening tool for stratifying the individual risk of developing GC ...

FINAL DIAGNOSIS:. POORLY DIFFERENTIATED LIPOSARCOMA WITH SPINDLE CELL, ROUND CELL COMPONENTS AND FOCAL OSSEOUS AND CHONDROID METAPLASIA. DICUSSION:. Liposarcoma is one of the most common soft tissue sarcoma in adults. Liposarcomas are usually large and occur most frequently in the lower extremities, retroperitoneal, perirenal, mesenteric region and shoulder area.. Grossly, they are well circumscribed but not encapsulated. They are divided into five subtypes: well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic. Mixed forms occur as seen in this case. The common morphologic denominator of liposarcoma is the lipoblasts. The criteria used for identifying lipoblasts include a hyperchromatic indented or sharply scalloped nucleus, lipid-rich (neutral fat) droplets in the cytoplasm, and an appropriate histologic background. Well-differentiated liposarcoma is the most common form with a peak incidence during sixth and seventh decades of life. Men and women are equally affected. ...

Barretts esophagus (BE) is the main pathological precursor of esophageal adenocarcinoma (EAC). Progression to high-grade dysplasia (HGD) or EAC from nondysplastic BE (NDBE), low-grade dysplasia (LGD) and indefinite for dysplasia (IND) varies widely between population-based studies and specialized centers for many reasons, principally the rigor of the biopsy protocol and the accuracy of pathologic definition. In the Republic of Ireland, a multicenter prospective registry and bioresource (RIBBON) was established in 2011 involving six academic medical centers, and this paper represents the first report from this network. A detailed clinical, endoscopic and pathologic database registered 3,557 patients. BE was defined strictly by both endoscopic evidence of Barretts epithelium and the presence of specialized intestinal metaplasia (SIM). A prospective web-based database was used to gather information with initial and follow-up data abstracted by a data manager at each site. A total of 2,244 ...

Answer: Oncocytic metaplasia with hyperplasia. Histology: The lesion is seen as a nodular expansion of oncocytic cells. At higher power, it is clear that the process is filling a duct and replacing the normal respiratory epithelium. The cells are characterized by abundant pink and somewhat granular cytoplasm. There is also focal oncocytic metaplasia in adjacent ducts.. Discussion: Oncocytic metaplasia with hyperplasia refers to the presence of oncocytic change with proliferation of the ductal epithelium. This change is most commonly encountered in the larynx as part of a ductal-type laryngeal cyst. It have also been reported in the nasopharynx where it is usually encountered as an incidental microscopic finding during panendoscopy with biopsy (Otolaryngol Head Neck Surg 1991; 105:86-91). Terminology varies, but common designations such as papillary oncocytic cystadenoma are misleading as they imply a neoplastic process. Most head and neck pathologist regard this process as metaplastic in nature ...

In earlier work it was found that the addition of excess of vitamin A (10 i.u./ml.) to the culture medium produces drastic changes in embryonic limb-bones and skin in organ culture. The matrix of cartilage (mouse, chick) and bone (mouse) rapidly disappears (Fell & Mellanby, 1952; Fell, Mellanby, & Pelc, 1956) and in the epidermis of skin from 7 to 18-day chick embryos (Fell & Mellanby, 1953; Fell, 1957; Pelc & Fell, 1960) keratinization is immediately arrested and a remarkable mucous metaplasia appears.. In a previous paper (Fell & Thomas, 1961) it was shown that when hydrocortisone (7·5 μg./ml.) is added together with vitamin A, resorption of intercellular material is greatly retarded in the explanted limb-bone rudiments. The present experiments were undertaken to see whether the hormone would also inhibit the metaplastic effect produced by vitamin A in the epidermis of embryonic chicken skin in vitro.. ...

Confirmation of endoscopically suspected esophageal metaplasia (ESEM) requires histology, but confusion in the histological definition of columnar-lined esophagus (CLE) is a longstanding problem. The aim of this study is to evaluate interpathologist variability in the interpretation of CLE. Thirty pathologists were invited to review three ten-case sets of CLE biopsies. In the first set, the... [Show full abstract ...

Marijuana users often inhale the unfiltered smoke and hold it deep in their lungs for as long as possible, bringing the smoke in direct contact with the lung tissue for long periods of time. Not only does this irritate the lungs and damage the way they work, it also exposes the lungs to some of the same cancer causing ingredients found in tobacco smoke. Cellular changes known as metaplasia are considered to be precancerous and can be found in human lung tissue upon examination of those who have used marijuana for several years. The tars from marijuana have produced tumors when applied to the skin of an animal and it is suggested that it is likely to cause cancer in humans as well ...

Pancreatic cancer is the fourth leading cause of cancer death in the United States with current 5-year survival rates at 6%. Greater than 90% of all pancreatic cancers harbor an activating mutation in codon 12 of the Kras gene (KrasG12D). Protein Kinase C iota (PKCι) has been shown to mediate KrasG12D downstream signaling and acinar-to-ductal metaplasia in an explant model of pancreatic cancer initiation. Additionally, inhibition of PKCι in human pancreatic cancer cells leads to decreased tumor size, angiogenesis, and metastasis in an orthotopic tumor model, suggesting that PKCι plays a role in maintaining the oncogenic phenotype of pancreatic cancer cells. We sought to test the hypothesis that PKCι plays a role development and maintenance of pancreatic cancer using a mouse model of KrasG12D-induced pancreatic cancer.. Purpose: To identify the effect of PKCι loss on pancreas function and development of KrasG12D-induced pancreatic cancer.. Procedures: Pancreata from mice with ...

- be able to identify simple columnar epithelium by understanding its morphology - know where simple columnar epithelium is located - know that this tissue has microvilli on its apical surface to increase its absorption ability - know what a goblet cell is and what it produces and secretes Here is an overview of simple columnar epithelia

Cystic fibrosis is characterized by dehydration of the airway surface liquid layer with persistent mucus obstruction. |i|Th2|/i| immune responses are often manifested as increased mucous cell density (mucous cell metaplasia) associated with mucus obstruction. IL-33 is a known inducer of |i|Th2|/i| i …

Yin Chen, PhD. is an Assistant Professor in Pharmacology and Toxicology in the College of Pharmacy at UA. Dr. Chens research focus is on epithelial biology. He was a research faculty in University of California, Davis and an Assistant Investigator in Chemical Industry Institute of Toxicology (former CIIT and later Hamner Institute). His long-term research objective is to understand the dysfunction of airway epithelial mucosa in the pathogenesis of a variety of acute and chronic airway diseases. His current research programs are: a) understanding the molecular mechanisms underlying airway mucous cell development and mucous cell metaplasia in chronic diseases including cancer, COPD and asthma; (b) understanding the function and regulation of novel COPD associated genes and developing novel compounds to treat COPD; (c) understanding the impact of fungal exposure on airway innate immunity and its contribution to the development and exacerbation of asthma. Dr. Chen has more than 30 publications ...

Introduction: Wood smoke (WS) exposure is associated with increased prevalence of chronic bronchitis and rapid decline in lung function. However, potency of WS and cigarette smoke (CS) in activating mucin gene expression has not been compared.. Aims and objectives: We tested the hypothesis that WS is more potent than CS in causing mucous cell metaplasia (MCM).. Methods: C57BL/6 mice were exposed for 30 d to filtered air (FA) or CS for 5 days/week and 6 hours/day at 250 mg/m3 total particulate matter (TPM) or to WS for 2 h/d at 10 mg TPM/m3. Extent of MCM was determined in stained lung sections. Mucin gene expression was analyzed by Western blot, qRT-PCR, and immunofluorescent staining. Findings were replicated in differentiated primary airway epithelial cultures from human (HAEC) and murine cells (MAECs).. Results: WS exposure at 25-fold lower TPM concentrations than CS increased Muc5ac, Muc5b, SPDEF and Bcl-2 mRNAs in the lungs of mice, while these mRNAs were not significantly increased by FA ...

Recent rapid increases in the incidence of oesophageal adenocarcinoma and Barretts metaplasia in western populations have led to a number of large-scale studies seeking to identify the causes of these conditions. Two of the largest and most comprehensive studies have been conducted in Australia. These studies have confirmed the long-standing clinical impression that gastro-oesophageal acid regurgitation is the principal cause of these diseases, and identified a number of other factors either positively (smoking, obesity) or negatively (H pylori infection, NSAIDs) associated with risk. Of these latter factors, it is the role of central obesity that has garnered most attention, since this may explain the five-fold higher incidence of this cancer amongst males compared with females. Genetic factors remain largely unexplored, although this will soon be rectified when the international Barretts Oesophagus and Adenocarcinoma Consortium (BEACON) completes their genome-wide association study in ...

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America. The highest risk factor for PDAC is recurrent pancreatitis. While the link between PDAC and pancreatitis is unknown, de-differentiation of acinar cells is common to both diseases. Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to the development of acinar-to-ductal cell metaplasia (ADM), a precursor phenotype of PDAC. The goal of this study was to identify how ATF3 contributes to ADM. I hypothesize that ATF3 regulates acinar gene expression promoting ADM. We observed decreased ADM development in Atf3-/- acinar cultures, along with expression changes in differentiation genes and ADM promoting pathways (EGFR) in vivo. Assessment following chronic injury indicated absence of ATF3 resulted in decreased tissue damage. These results suggest a novel mechanism where ATF3 promotes ADM through loss of the mature acinar cell phenotype.

The structural features of airways in patients with COPD are airway wall inflammation, fibrosis, muscle hypertrophy, and goblet cell metaplasia. These structural cellular changes contribute to mucus...

An intraosseous lipoma is a rare histologic variant of lipoma, accounting for only 0.1% of all primary bone tumors. This may not be the actual incidence because most of these lesions are frequently asymptomatic, but imaging modalities, such as computed tomography or magnetic resonance imaging (MRI) seem to have increased the detection rate. Lipoma occasionally undergoes osseous metaplasia and becomes an osseous lipoma. Although there are numerous papers discussing intraosseous lipoma and some authors have tried to differentiate lipomas from osseous lipomas, there is still a great deal of confusion with regard to characteristic radiologic features and the use of terms ...

The osseous metaplasia only exists at the margin -- there is no iris anymore and the lens is transparent. That is blood and pus you are seeing. We have tried oral and topical antibiotics with no difference. I do not know if the eye bothers her. She does not paw at it but she does show signs of pain; however, she has numerous other health conditions including severe arthritis in her back. I put Atropine ointment on the eye and she gets Torb twice daily ...

Patients with chronic gastro-oesophageal reflux disease are predisposed to Barretts metaplasia and oesophageal adenocarcinoma. The availability of molecular markers that can objectively identify patients with Barretts ...

Although stomach cancer is treatable if detected early, diagnosis often occurs at an advanced stage, resulting in high mortality. A new study by researchers at the National University Health System and Duke-NUS Medical School has identified genetic patterns in intestinal metaplasia (a precondition for stomach cancer) which help predict the development of this life-threatening cancer. The discovery could enable targeted screening and earlier detection of stomach cancer, leading to better patient outcomes.

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Junes publication of the Gastrointestinal Endoscopy estimates an accurate recurrence risk after complete remission of intestinal metaplasia through endoscopic therpay ...

In the pre-published stage, this manuscript may contain statements, opinions, and information that have errors in facts, figures, or interpretation. Any final changes in this manuscript will be made at the time of publication and will be reflected in the final electronic version of the issue. The editors and authors and their respective employees are not responsible or liable for the use of any such inaccurate or misleading data, opinion or information contained in the articles in this section.. ...

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Metaplasia of the lower oesophagus from squamous to columnar cells. It is considered a premalignant condition for oesophageal carcinoma ...

Epithelium Pink transparent png is about Epithelium, Simple Columnar Epithelium, Pseudostratified Columnar Epithelium, Cell Biology, Tissue, Desmosome, Stratified Squamous Epithelium, Simple Cuboidal Epithelium, Cell Junction, Gap Junction, Endothelium, Biology, Medical Imaging

Metaplasia is the replacement of one cell by another, sometimes less differentiated, cell type. An example is the replacement of columnar ciliated epithelial cells of the bronchial lining by stratified squamous epithelial cells due to smoking. ...

Gastritis chronica/+/activa/-/cum atrophia/+/Hyperplasia foveolaris/+/ Metaplasia intestinalis non completa/++/Fibrosis laminae propriae/+/Erytrorrhagiae punctatae mucoss

Dr Philip Jayasurya (University Hospital Plymouth) and Dr Tim Bracey A 62-year-old female presented to the ENT outpatient department with a history of discomfort in the back of the throat. Examination revealed nodularity in the right and left post nasal space with tongue base asymmetry. Biopsies from the post nasal space showed extracellular eosinophilic deposits … Continue reading AMYLOIDOSIS AND ONCOCYTIC METAPLASIA OF THE NASOPHARYNX: A CASE REPORT. ...

All joking aside, I have been to Columbus a lot lately, and have been diagnosed with a very rare form of dysplasia in my eye. This is why I havent been posting. Turns out pathology says it is metaplasia, less serious, and NO carcinoma cells present. Still, a little snip snip here and a snip snip there, thats how they work the day away in the merry old land of OSU. They got it all, so all is well again in the land of Oz ...