Background: The prevalence of metabolic syndrome (MS) after renal transplantation has yet to be elucidated. In the present study, we investigated the prevalence of MS in Japanese renal transplant recipients.. Methods: A cross-sectional study was conducted to determine the prevalence of MS in 101 renal transplant recipients at Osaka City University Hospital. The prevalence of MS was determined using the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria (modified and original) and the International Diabetes Federation (IDF) criteria.. Results: Using the modified (Japanese) NCEP criteria, a total of 24 out of 101 patients (23.8%) had MS including 21 out of 64 male patients (32.8%) and three out of 37 female patients (8.1%). Using the modified (Asian) NCEP criteria, MS was diagnosed in 23 patients (22.8%); 19 male (29.7%) and four female (10.8%). Using the original NCEP criteria, MS was diagnosed in 15 patients (14.9%); 12 male (18.8%) and three female (8.1%). ...
Thiamine deficiency has suggested to be linked to several insulin-resistance complications. In this study, we aim to associate circulating thiamine levels among cardiometabolic parameters in an Arab cohort using a simple, sensitive, rapid and selective high-performance liquid chromatography (HPLC) method that has recently been developed. A total of 236 randomly selected, consenting Saudi adult participants (166 males and 70 females) were recruited and screened for the presence of the metabolic syndrome (MetS) using the modified National Cholesterol Education Program-Adult Treatment Panel III definition. Blood thiamine and its derivatives were quantified using HPLC. A total of 140 participants (53.9%) had MetS. The levels of thiamine and its derivatives of those with MetS were not significantly different from those without. However, hypertensive subjects had significantly higher urinary thiamine (P = 0.03) as well as significantly lower levels of thiamine diphosphate (TDP) (P = 0.01) and total thiamine
Researchers analyzed data from more than 27,000 healthy middle-aged women taking part in the Womens Health Study. They found that 25 percent had metabolic syndrome.. Metabolic syndrome is a cluster of risk factors linked to being overweight or obese. The risk factors are a large waistline, high blood pressure, low HDL ("good") cholesterol, high triglyceride levels, and higher-than-normal blood sugar.. In this study, women with three or more of these risk factors were considered to have metabolic syndrome.. During an average of 13 years, 114 of all the women developed PAD. Women with metabolic syndrome had a 62 percent higher risk for PAD than women who did not have metabolic syndrome. Each metabolic syndrome risk factor raised the risk for PAD by 20 percent.. The link between metabolic syndrome and PAD in women was largely explained by increased inflammation. Women with metabolic syndrome had higher levels of two markers of inflammation than their peers who did not have the syndrome.. ...
Introduction: There is little evidence on the association between resistance exercise and incident metabolic syndrome.. Hypothesis: We examined the hypothesis that resistance exercise reduces the risk of developing metabolic syndrome in men.. Methods: Participants were 6,098 men aged 18 to 83 years (mean age, 46) who received an extensive preventive medical examination during 1987-2006, and were free of cardiovascular disease, cancer, and metabolic syndrome at baseline. Resistance exercise was assessed by self-reported muscle strengthening activities using either free weights or weight training machines. We used the frequency of resistance exercise (0, 1, 2, 3, 4, and ≥5 days/week) as our main exposure categories. Metabolic syndrome was defined as the presence of ≥3 of the following criteria: waist circumference ,102 cm, triglycerides ≥150 mg/dL, high-density lipoprotein cholesterol ,40 mg/dL, systolic/diastolic blood pressure ≥130/85 mm Hg or physician-diagnosed hypertension, and ...
The purpose of the study is to evaluate the blood pressure lowering effect and safety of aliskiren in combination with Hydrochlorothiazide (HCTZ) compared to aliskiren monotherapy when given to metabolic syndrome patients with stage 2 systolic hypertension (mean sitting systolic blood pressure [msSBP] ≥ 160 mm Hg and , 200 mm Hg ...
1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-2497. 2. Grundy SM, Hansen B, Smith SC et al. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 2004; 109(4): 551-556. 3. Griffin BA, Freeman DJ, Tait GW et al. Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis 1994; 106(2): 241-253. 4. Arsenault BJ, Lemieux I, Despres JP et al. The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results ...
The objective of this systematic review were to determine the effectiveness of lifestyle interventions on the prevalence of metabolic syndrome and on independent, modifiable risk factors for metabolic syndrome in people with metabolic syndrome. Randomised controlled trials published in English that evaluated the effectiveness of supervised, multifaceted lifestyle interventions in people with metabolic syndrome were included. Lifestyle interventions were defined as any supervised intervention involving both diet and exercise with or without other components, such as counselling. The risk of bias of the included trials was assessed using the PEDro scale, and these were used to determine the quality of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Outcomes were prevalence of metabolic syndrome, risk factors for metabolic syndrome (eg, waist circumference, triglycerides, systolic blood pressure, body mass index), and quality of life. ...
People who undergo blood testing to find out whether they have metabolic syndrome are likely to be worried about their heart health. However, new research from the University of Wisconsin School of Medicine and Public Health suggests that metabolic syndrome may also be harmful to the brain ...
Our objective was to perform a quantitative review of prospective studies examining the association between the metabolic syndrome and incident diabetes.,Using the title terms "diabetes" and "metabolic syndrome" in PubMed, we searched for articles published since 1998.,Based on the results from 16 cohorts, we performed a meta-analysis of estimates of relative risk (RR) and incident diabetes. The random-effects summary RRs were 5.17 (95% CI 3.99-6.69) for the 1999 World Health Organization definition (ten cohorts); 4.45 (2.41-8.22) for the 1999 European Group for the Study of Insulin Resistance definition (four cohorts); 3.53 (2.84-4.39) for the 2001 National Cholesterol Education Program definition (thirteen cohorts); 5.12 (3.26-8.05) for the 2005 American Heart Association/National Heart, Lung, and Blood Institute definition (five cohorts); and 4.42 (3.30-5.92) for the 2005 International Diabetes Federation definition (nine cohorts). The fixed-effects summary RR for the 2004 National Heart, ...
Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity.: MetS frequency was higher in RA patients t
The lack of previous studies about metabolic syndrome in Bolivia makes it interesting to know the actual situation in one of the poorest country in South America. The number of patients was not the ideal to try to show the prevalence in the entire country, but it would be an initial point for future studies.. The economical situation was an important determinant factor in our study since many obese children were not included because of lack of enough money for medical visits and some of the diagnostic test that were not financed by research committee of the hospital.. Insulin resistance was found in 39.4% of obese children and adolescents. This rate is similar as other found in studies conducted in developing countries like France, Italy, Spain and United States of America. [15-19]. There are no clear definition for metabolic syndrome in children and adolescents, existing different criteria used according to the place or population of the study. [20-24] NCEP-ATP III definition with modified ...
Metabolic syndrome is a condition that includes the presence of a cluster of risk factors specific for cardiovascular disease.. Metabolic syndrome significantly raises the risk of developing diabetes, heart disease, and/or stroke.. Most people who have metabolic syndrome have insulin resistance.. The body makes insulin to move glucose (sugar) into cells for use as energy.. Obesity, commonly found in persons with metabolic syndrome, makes it more difficult for cells to respond to insulin.. If the body cannot make enough insulin to override the resistance, the blood sugar level increases and diabetes can result. Metabolic syndrome may be a beginning of the development of type 2 diabetes.. Because metabolic syndrome and insulin resistance are closely associated, many healthcare professionals believe that insulin resistance may be a cause of metabolic syndrome.. However, a direct link between the two conditions has not been established.. Others believe that hormone changes, caused by chronic stress, ...
How does the metabolic syndrome affect stroke risk?. Metabolic syndrome increases the risk of stroke in all ethnic groups and both sexes. Having the metabolic syndrome approximately doubles your risk of having a stroke compared with healthy persons, and the syndrome is estimated to account for 30% of all blocked-vessel (ischemic) strokes in women. Nearly half of all strokes occur in people who have the metabolic syndrome.. Each component of the metabolic syndrome increases your risk of a first or repeat blocked-vessel stroke. The more of these components you have, the higher your risk of developing stroke. High blood pressure, high cholesterol, and low HDL (good) cholesterol are all individual risk factors for atherosclerosis, meaning they can cause fatty deposits (plaque) to build up on the walls of your blood vessels and reduce blood flow to the brain. In a study of 1895 adults (59% were women), the metabolic syndrome increased by 36% the risk of developing plaque in the carotid arteries in ...
Background: We aimed to assess the burden of metabolic syndrome (MetS), and evaluate the phenotypic variation of MetS in a population at high risk for diabetes in urban Karachi, Pakistan. Methods: This study was embedded in a lifestyle intervention trial for the prevention of type 2 diabetes mellitus. The study population comprised participants who belonged to urban households in Karachi, Pakistan. Results: Among 15,590 individuals who were screened through diabetes risk score (DRS), 3945 individuals met the criteria for a high DRS (≥60). After excluding 1780 participants due to refusals and ineligibility, 2165 were enrolled, a total of 1188 subjects (54.9%) met the International Diabetes Federation criteria for MetS, and a total of 1199 subjects (55.4%) participants met the US National Cholesterol Education Program. Raised serum triglycerides (TGs) and low high-density lipoprotein (HDL) cholesterol were significantly associated with MetS. On multivariate logistic regression, higher body mass index
Background: The prevalence of metabolic syndrome (MetS) is growing rapidly in China. Tai chi and dancing are common types of exercise among middle-aged and elderly Chinese. It remains unclear whether these activities are associated with a lower risk of MetS. Methodology/Principal Findings A total of 15,514 individuals (6,952 men, 8,562 women) aged 50 to 70 years from the Dongfeng-Tongji Cohort in Shiyan, China participated in a cross-sectional study. Physical activity and other lifestyle factors were assessed with semi-structured questionnaires during face-to-face interviews. MetS was defined by the current National Cholesterol Education Program/Adult treatment Panel III criteria for Asian Americans. The prevalence of MetS was 33.2% in the study population. In the multivariable-adjusted logistic regression analyses, total physical activity levels were monotonically associated with a lower odds of MetS [OR 0.75 comparing extreme quintiles, 95% confidence interval (CI) 0.66-0.86, P,0.001]. ...
Eur J Gastroenterol Hepatol. 2014 Mar 17. [Epub ahead of print]. Aziz H1, Gill U, Raza A, Gill ML.. Abstract. INTRODUCTION: Hepatitis C viral (HCV) infection is caused by an RNA virus. HCV infection is considered to induce systemic disease that causes steatosis, alters lipid metabolism, and results in metabolic syndrome. This study aimed to investigate the therapeutic outcome in HCV genotype 3 patients with metabolic syndrome.. MATERIALS AND METHODS: A total of 621 HCV-positive patients who visited the hospital for treatment were screened. Among these, 441 patients were enrolled for antiviral therapy. These enrolled patients were assessed for metabolic syndrome according to the International Diabetes Federation criteria. Group A included patients with metabolic syndrome and group B included patients without metabolic syndrome. All patients received peginterferon-α2a (180 μg/week) and ribavirin (10 mg/kg/day) for 6 months.. RESULTS: The prevalence of metabolic syndrome in chronic HCV patients ...
... treatment center in Indianapolis, IN. Discover what is cardiometabolic syndrome, learn the symptoms, and find proper treatment of Cardiometabolic Syndrome.
One of the most interesting facts about metabolic syndrome is that it was introduced in medical textbooks very recently, in 1998 and its causes are still being researched. Other names for metabolic syndrome include "syndrome X", "insulin resistance syndrome," and "American syndrome". However, this condition is very widespread, some experts estimating that it is as common as acne and the common cold. In the United States, more than 45 million people have it. One in six people is expected to develop metabolic syndrome at one point in their lives, especially after the age of 65. In the past years, the incidence of metabolic syndrome has increased, one possible cause being the rise in obesity rates. At present, it is estimated that almost 35% of Americans suffer from metabolic syndrome. Nearly half the instances of metabolic syndrome occur in people over the age of 60.. ...
#Obesity#Metabolic Syndrome - Metabolic are the biochemical processes that are involved in the normal functioning of your body. Risk factors are common traits, habits or conditions that raise your risk of developing a disease. Metabolic syndrome is the term used for a group of factors that increase your risk of developing the cardiac diseases and other health issues, like stroke and diabetes. Metabolic syndrome is becoming a prevalent disorder due to a sharp rise in the rate of obesity among adults. Metabolic syndrome may soon overtake smoking as the dominant risk factor responsible for heart disorders. The following are some of the dominant symptoms of metabolic syndrome: -Abdominal obesity -A high level of Triglyceride( 150 and higher) -A lowered level of HDL (good cholesterol) -Blood pressure of 130/85 and above -Increased level of blood sugar (fasting) of 110 or more It is not impossible to prevent the onset of metabolic syndrome. Slight lifestyle alterations can help to delay the
TY - CONF. T1 - Influence of metabolic syndrome on clinic and 24-h pulse pressure in essential hypertension.. AU - Mulè, G. AU - Cerasola, Giovanni. AU - Cottone, Santina. AU - Mule, Giuseppe. AU - Nardi, Emilio. AU - Cusimano, Paola. AU - Palermo, Alessandro. PY - 2007. Y1 - 2007. KW - metabolic syndrome, pulse pressure, hypertension. UR - http://hdl.handle.net/10447/37764. M3 - Paper. ER - ...
Continuous and dichotomous metabolic syndrome definitions in youth predict adult type 2 diabetes and carotid artery intima media thickness: the Cardiovascular Risk in Young Finns Study
Although aspects of diet have been linked to individual metabolic features of the metabolic syndrome (2,3,17,18), the role of dietary factors in the etiopathogenesis of this syndrome has been poorly investigated (20). As far as type 2 diabetes is concerned, conflicting relationships with carbohydrates and fat intake have been reported (28,29). Grouping diseases that share a common etiopathogenetic basis was an attempt to clarify the relationships of the insulin resistance syndrome with dietary factors. We had an opportunity to study a population of Japanese ancestry that was shown to be highly susceptible to metabolic syndrome when exposed to the Western world (30). Since 1993, our group has followed a cohort of Japanese Brazilians with high prevalence of central obesity, diabetes, dyslipidemia, and hypertension (8,9,12).. The definition of metabolic syndrome used in the present study introduced a modification to the National Cholesterol Education Program criteria with respect to the waist ...
Metabolic syndrome (MetS) is a cluster of conditions that conjoined represents a 1.5-2.5 fold increased risk of developing cardiovascular disease (CVD). Recent studies have reported that gut dysbiosis and leakage of bacterial components, may contribute to the metabolic disturbances and systemic inflammation observed in subjects with MetS. Chronic exposure to lipopolysaccharide (LPS) has been shown to induce features of MetS in experimental studies. LPS interacts with the innate immune system, facilitated through LPS-binding protein (LBP) and the co-receptor CD14, both regarded as markers of gut leakage. We investigated whether circulating levels of LBP and sCD14 are associated with the presence of MetS and its components, and further any association with systemic inflammation. We examined 482 men, aged between 65 and 75 years, all at high CVD risk. MetS criterias according to the US National Cholesterol Education Program Adult Treatment Panel III were met in 182 subjects (38%). Levels of LBP and sCD14
Forty-four participants were phenotyped according to BMI as non-obese vs obese (,30 or ,30 kg/m2) and according to the International Diabetes Federation criteria of MetS: ≤2 criteria MetS (MetS−) vs ≥3 criteria MetS (MetS+); (1.)non-obese MetS− vs (2.) non-obese MetS+ and (3.) obese MetS− vs (4.) obese MetS+. Flow-mediated dilation (FMD), body composition including liver fat (MRI and spectroscopy), dietary intake, intensities of habitual physical activity and cardio-respiratory fitness were determined. Variables were analysed using a one-factor between-groups ANOVA and linear regression; mean (95% CI) are presented. ...
People with schizophrenia have a higher risk of metabolic syndrome (also referred to as syndrome X or the dysmetabolic syndrome) than the general population. Metabolic syndrome is a cluster of related symptoms that puts the individual at increased risk of diabetes and cardiovascular disease such as heart-attack and stroke. Metabolic syndrome generally includes some or all of the following: elevated blood pressure, abdominal obesity, diabetes or "prediabetes" (impaired glucose tolerance, impaired fasting glucose or insulin resistance), dyslipidemia (high levels of triglycerides and/or HDL - the "bad" cholesterol), and inflammatory markers. It is the leading natural cause of increased rate of death in people with schizophrenia. An article by Dr. Jonathan M. Meyer, MD in the Psychiatric Times summarizes new findings exploring the link between metabolic syndrome and schizophrenia, and presents recent consensus recommendations for preventing and monitoring metabolic syndrome or "dysfunction". He ...
RESEARCH DESIGN AND METHODS This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups. ...
INTRODUCTION: the aim of this study was to investigate the prevalence of metabolic syndrome in Sokoto metropolis of North-Western Nigeria. METHODS: a cross-sectional community based study was carried out. Four hundred and ten subjects (201 males and 209 females) were recruited for the study using a multi-stage sampling technique. Demographic and the life style data was obtained from the participants. Evaluation of anthropometric variables, fasting blood sugar, lipid profiles, insulin resistance and blood pressure was performed. The classification of metabolic syndrome was based on the NCEP ATP III guidelines. RESULTS: the mean (SD) age of the sample population was 39.6 (14.4) years. The mean (SD) age of the male subjects was 38.4(14.9) years and that of the females was 40.8(13.9) years (p> 0.05). The overall prevalence of metabolic syndrome was 35.1% with the females having 42.83% and the males 27.36%. The frequencies of metabolic syndrome parameters in the study subjects were low HDL (56.1%),
There are other names for metabolic syndrome, which include syndrome X, insulin resistance syndrome, metabolic syndrome X and cardiometabolic syndrome.. Research studies have shown a definite connection between high triglycerides, metabolic syndrome and the development of diseases and conditions such as Type 2 diabetes, heart and vascular diseases, and fatty liver. Research also shows that the incidence of metabolic syndrome has risen over 10% since 1988.. Metabolic Syndrome and Liver Cancer. In its recent study, the National Cancer Institute discovered that people who have metabolic syndrome may be more likely to develop liver cancer. The study examined the medical histories of people diagnosed with liver cancer. The data was then compared to the medical histories of healthy people. The results? More than 37% of those with liver cancer had pre-existing metabolic syndrome compared to 17.1% of healthy people with the syndrome.. Sadly, along with the rise of high triglycerides, and the increase in ...
This study involved high-intensity aerobic-interval training. For more bang for you time one can obtain the positive heart benefits, have a positive effect on your metabolism, and also increase strength at the same time with high intensity interval strength training. High intensity interval strength training can increase metabolism four ways.. The type of strength training we do at New Orleans Fitness Trainers and atAustin Fitness Trainers is high intensity interval training (HIIT). It is a full body workout where a series of strength training exercises are performed with little rest between the exercises. Strength training has more to offer than stronger muscles and bones; it is a heart healthy and beneficial to your metabolism as well. ...
There are few existing large population studies on the epidemiology of metabolic syndrome-related disorders of Turkey. The purpose of this study was to assess the prevalence of metabolic syndrome-related disorders in the Turkish adult population, to address sex, age, educational and geographical differences, and to examine blood pressure, body mass index, fasting blood glucose and serum lipids in Turkey. This study was executed under the population study The Healthy Nutrition for Healthy Heart Study conducted between December 2000 and December 2002 by the Health Ministry of Turkey. Overall, 15,468 Caucasian inhabitants aged over 30 were recruited in 14 centers in the seven main different regions of Turkey. The data were analyzed with the Students t, ANOVA or Chi-Square tests. Overall, more than one-third (35.08 %) of the participants was obese. The hypertensive people ratio in the population was 13.66 %, while these ratios for DM and metabolic syndrome were 4.16 % and 17.91 %, respectively. The
Explore metabolic syndrome. National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/ms. Accessed October 31, 2019.. Metabolic syndrome. American Heart Association website. Available at: http://www.heart.org/HEARTORG/Conditions/More/MetabolicSyndrome/Metabolic-Syndrome_UCM_002080_SubHomePage.jsp. Accessed October 31, 2019.. Metabolic syndrome in adults. EBSCO DynaMed website. Available at:https://www.dynamed.com/condition/metabolic-syndrome-in-adults. Updated March 29, 2018. Accessed October 31, 2019.. Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin North Am. 2014 Mar;43(1):1-23.. 1/22/2015 DynaMed Systematic Literature Surveillancehttp://www.dynamed.com/topics/dmp~AN~T113812/Metabolic-syndrome-in-adults: Xu Y, Shen S, Sun L, et al. Metabolic syndrome risk after gestational diabetes: Asystematic review and meta-analysis. PLoS One. 2014;9(1):e87863.. 7/15/2015 DynaMed Systematic Literature ...
MONDAY, Jan. 18 (HealthDay News) -- Metabolic syndrome that persists over years is associated with worse cognitive function in late middle age, which can be partially accounted for by occupational position, according to a study in the January issue of Diabetes Care.. Tasnime N. Akbaraly, Ph.D., of University College London, and colleagues examined the association between metabolic syndrome (assessed three times over 10 years) and cognitive function in 4,150 Caucasian late middle-aged British civil servants.. Over a 10-year follow-up, and after adjusting for health and demographics, the researchers found that individuals with persistent metabolic syndrome (found at least twice) had significantly lower cognitive function than individuals who never had metabolic syndrome. There were no significant differences in cognitive function between participants with non-persistent metabolic syndrome (found only once) and those who never had metabolic syndrome. Adjusting for education had little effect, while ...
The cardiometabolic syndrome has been defined as an all-encompassing constellation of metabolic risk factors-including the metabolic syndrome-that culminates in increased cardiovascular risk.10 Researchers have estimated that as many as 70 million Americans (approximately 34% of the adult population) have cardiometabolic syndrome.10 The prevalence of this syndrome varies substantially throughout the world. For example, an analysis of patients in Mexico conducted from 1997 to 1999 revealed a cardiometabolic syndrome prevalence of 60% in men and 40% in women.10 These findings contrasted sharply with the findings of a 1996 study of patients in France, which indicated a cardiometabolic syndrome prevalence of 10% in men and 7% in women.11 Most likely, both lifestyle and genetic factors play a role in such population differences. ...
Background: ALP and GGT are indispensable constituents of brain microvessel endothelial cells, expressed and induced by IL-6. High values are entangled in affecting blood-brain barrier functionality. Since SOD bound to brain basement membrane and matrix heparan sulfate proteoglycan, is implicated in β-amyloid efflux, we examined in a pilot study of 11 patients with metabolic syndrome (MS) whether these biomarkers can be beneficially influenced through an antioxidant phytochemical approach with Ginkgo biloba (EGb 761, 2 × 120 mg/d). Also, MS is associated with an increased risk of developing diabetes and cardio-cerebro-vascular diseases (CCVD) (Figure).. Methods: Photometric methods, ELISAs, EIAs and laser ellipsometry were applied.. Results: A 2-month medication led to brain/liver biomarker changes: ALP -14.8% (p , 0.004), GGT -11.3% (p , 0.010). Antioxidative biomarker changes: SOD +17.7% (p , 0.009), GPx +11.6% (p ,0.001), oxLDL/LDL -21.0% (p , 0.002), 8-iso-PGF2α -39.8% (p , 0.003), MPO ...
Background: Aim of this study was to address the impact of the metabolic syndrome (MetS) on post-procedural myocardial infarction (pMI) after percutaneous coronary intervention (PCI).. Methods: The first native coronary lesion treated with PCI per patient was analyzed. Exclusion criteria were any increase in Creatine phosphokinase (CPK) or creatine kinase-MB (CK-MB) above upper normal limit at baseline; left ventricular ejection fraction , 30%; renal failure with creatinine , 3 mg/dL. 142 patients with 142 lesions fulfilled the inclusion criteria. We identified MetS by the International Diabetes Federation definition [ethnicity/gender adjusted abdominal obesity measured by waist circumference plus two or more criteria]. CPK and CK-MB were measured at baseline and at 18 hours after PCI. pMI was defined as a post-procedural increase of CK-MB , 2 times above the upper normal limit. Using 64-slice MDCT before PCI, we also performed volumetric plaque analysis of the target lesion in 28 patients with ...
Metabolic syndrome is rapidly emerging as an epidemic of global proportions and its definition is still evolving. Patients with this syndrome are at increased risk for cardiovascular disease, and at increased risk of mortality from cardiovascular disease.. Metabolic syndrome is strongly associated with obesity, and more specifically with abdominal obesity. Abdominal obesity, comprises two main components: visceral (VAT) and subcutaneous (SAT) adipose tissue depots, with VAT reported as more metabolically active than SAT, and thought to play a major role in the metabolic disturbances associated with obesity and metabolic syndrome.. Non-alcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease and is associated with obesity, insulin resistance and metabolic syndrome.. Bariatric surgery has yielded dramatic results including longitudinal loss of excess body weight and either complete reversal or significant improvement of several features of metabolic syndrome, NAFLD, and ...
In the present prospective study of a large Japanese working population, we demonstrated that the optimal cut-off points of WC for predicting DM were 85 and 80 cm for men and women, respectively. In the comparison of the JCCMS criteria, the JIS criteria using the above WC cut-off points provided the highest sensitivity for predicting DM. To our knowledge, this is the first prospective study in Japan to assess the optimal WC cut-off points for predicting DM and to compare the predictive abilities of different MetS criteria for the development of DM.. In the present study, the incidence rate of DM was 14.7 per 1000 person-years for men and 6.5 per 1000 person-years for women. According to a systematic review and meta-analysis of Japanese studies [28], the incidence rates of DM showed varied considerably among studies (2.3-52.6 per 1000 person-years). This could be attributable to differences in background characteristics (e.g., age and gender), follow-up durations, and diagnostic procedures among ...
Obesity has been linked to the human gut microbiota; however, the contribution of gut bacterial species to the obese phenotype remains controversial because of conflicting results from studies in different populations. To explore the possible dysbiosis of gut microbiota in obesity and its metabolic complications, we studied men and women over a range of body mass indices from the Old Order Amish sect, a culturally homogeneous Caucasian population of Central European ancestry. We characterized the gut microbiota in 310 subjects by deep pyrosequencing of bar-coded PCR amplicons from the V1-V3 region of the 16S rRNA gene. Three communities of interacting bacteria were identified in the gut microbiota, analogous to previously identified gut enterotypes. Neither BMI nor any metabolic syndrome trait was associated with a particular gut community. Network analysis identified twenty-two bacterial species and four OTUs that were either positively or inversely correlated with metabolic syndrome traits, suggesting
TY - JOUR. T1 - Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort. T2 - A nested case-control study. AU - Agnoli, C.. AU - Berrino, F.. AU - Abagnato, C. A.. AU - Muti, P.. AU - Panico, S.. AU - Crosignani, P.. AU - Krogh, V.. PY - 2010/1. Y1 - 2010/1. N2 - Background and aims: The increase in breast cancer incidence over recent decades has been accompanied by an increase in the frequency of metabolic syndrome. Several studies suggest that breast cancer risk is associated with the components of metabolic syndrome (high serum glucose and triglycerides, low HDL-cholesterol, high blood pressure, and abdominal obesity), but no prospective study has investigated risk in relation to the presence of explicitly defined metabolic syndrome. We investigated associations between metabolic syndrome, its components, and breast cancer risk in a nested case-control study on postmenopausal women of the ORDET cohort. Methods and results: After a median follow-up of 13.5 years, 163 women ...
Metabolic syndrome is describes as a clustering of cardiovascular risk factors, such as, abdominal obesity, dyslipidemia, hyperglycaemia and hypertension. There are so many risk factors are common in Type 2 diabetes and cardiovascular disease, and many of these risk factors are highly correlated with one another. The risk factors of the metabolic syndrome are of metabolic origin and composed of atherogenic dyslipidemia, high plasma glucose level, elevated blood pressure, a prothrombotic state, and a pro inflammatory state. The management of persons with metabolic syndrome should have to focus not only on blood glucose control but also includes approaches for reduction of other cardiovascular disease risk factors. The present study aims to understand the prevalence of metabolic syndrome and its association with type 2 diabetes. The study group included 150 type 2 diabetes patients in the age group ranging between 20-80 years. Waist and hip circumference, BMI, Blood pressure, fasting blood glucose and
About metabolic syndrome. American Heart Association website. Available at: https://www.heart.org/en/health-topics/metabolic-syndrome/about-metabolic-syndrome#.V1bFWk2FMdU. Accessed August 27, 2018.. Metabolic syndrome. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/nutritional-disorders/obesity-and-the-metabolic-syndrome/metabolic-syndrome. Updated December 2016. August 27, 2018.. Metabolic syndrome. National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/metabolic-syndrome. Accessed August 27, 2018.. Metabolic syndrome in adults. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T113812/Metabolic-syndrome-in-adults. Updated March 29, 2018. Accessed August 27, 2018.. 4/15/2011 DynaMed Plus Systematic Literature Surveillancehttp://www.dynamed.com/topics/dmp~AN~T113812/Metabolic-syndrome-in-adults: Mottillo S, Filion KB, Genest J, et al. The metabolic syndrome and ...
1. Wong SK, Chin K-Y, Ima-Nirwana S. Toll-like Receptor as a Molecular Link between Metabolic Syndrome and Inflammation: A Review. Curr Drug Targets. 2019;20:1264-80 2. Samson SL, Garber AJ. Metabolic Syndrome. Endocrin Metab Clin. 2014;43:1-23 3. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA. et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640-5 4. Mohamud WN, Ismail AA, Sharifuddin A, Ismail IS, Musa KI, Kadir KA. et al. Prevalence of metabolic syndrome and its risk factors in adult Malaysians: results of a nationwide survey. Diabetes Res Clin Pract. 2011;91:239-45 5. Aminuddin A, Zakaria Z, Fuad AF, Kamsiah J, Othman F, Das S. et al. High C reactive protein ...
Metabolic syndrome is a group of health problems that increase your chance of heart disease. It also increases your risk of developing breast cancer. If you have metabolic syndrome, taking preventive steps to manage it now is important because having it longer may put you at greater risk.. In a recent eight-year study by the American Association for Cancer Research, researchers looked at whether women were more likely to develop breast cancer after menopause if they had metabolic syndrome. While simply having metabolic syndrome only slightly increased risk, women who had metabolic syndrome three to five years before their breast cancer diagnosis had about double the risk. ...
An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is provided. A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also provided. The system and method include use of a set of ion permeable barriers and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or plasma.
Background: Our aim was to study the frequency of metabolic syndrome and associated factors in patients with schizophrenia. Method: The study group consisted of 35 outpatients with long-term schizophrenia defined by DSM-IV criteria. Patients were assessed for the presence of metabolic syndrome, which was defined by the criteria of the National Cholesterol Education Program. All patients were on antipsychotic medication. Data were collected from Jan. 1, 2001, to Aug. 30, 2001. Results: Metabolic syndrome was found in 37% (N = 13) of the patients, and it was associated inversely with the total daily dose of, but not with any specific type of, antipsychotic drug. Conclusion: The results suggest that metabolic syndrome is common among patients with schizophrenia, and it may be far more common than in general populations. ...
February 19, 2011. Being Overweight Could Be Making You Forgetful. By Mary Brophy Marcus. USA TODAY. Older people who have larger waistlines, high blood pressure and other risk factors associated with a condition doctors call "metabolic syndrome" may be at higher risk of memory problems, a new study suggests.. In the large French study, older adults with metabolic syndrome were 20% more likely to have cognitive decline on a memory test than those without it.. "Our study sheds new light on how metabolic syndrome and the individual factors of the disease may affect cognitive health," study author Christelle Raffaitin of the French National Institute of Health Research in Bordeaux said in a press statement. "Our results suggest that management of metabolic syndrome may help slow down age-related memory loss, or delay the onset of dementia.". Read more about the study here.. Feb. 18, 2011. Repeat MRI Screening Results In Fewer False Positives. NewsRx.com. OAK BROOK, Ill. - MRI screening for breast ...
TY - JOUR. T1 - CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. AU - Esteghamat, Fatemehsadat. AU - Broughton, James S.. AU - Smith, Emily. AU - Cardone, Rebecca. AU - Tyagi, Tarun. AU - Guerra, Mateus. AU - Szabó, András. AU - Ugwu, Nelson. AU - Mani, Mitra V.. AU - Azari, Bani. AU - Kayingo, Gerald. AU - Chung, Sunny. AU - Fathzadeh, Mohsen. AU - Weiss, Ephraim. AU - Bender, Jeffrey. AU - Mane, Shrikant. AU - Lifton, Richard P.. AU - Adeniran, Adebowale. AU - Nathanson, Michael H.. AU - Gorelick, Fred S.. AU - Hwa, John. AU - Sahin-Tóth, Miklós. AU - Belfort-DeAguiar, Renata. AU - Kibbey, Richard G.. AU - Mani, Arya. PY - 2019/8/1. Y1 - 2019/8/1. N2 - Factors that underlie the clustering of metabolic syndrome traits are not fully known. We performed whole-exome sequence analysis in kindreds with extreme phenotypes of early-onset atherosclerosis and metabolic syndrome, and identified novel loss-of-function ...
Dedicated guidelines for the management of hyperlipidaemia secondary to HAART have been developed by the Infectious Disease Society of America (IDSA) and Adult AIDS Clinical Trials Group (AACTG).49 These recommendations are largely based on National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines, and advocate adjusting individual cholesterol levels through estimation of Framingham predicted 10-year CV risk. Currently, there is no difference in hyperlipidaemia target goal treatment between HIV and non-HIV patients. European Society of Cardiology/European Atherosclerosis Society 2011 lipid guidelines50 for the first time pointed out that HIV-infected patients represent a high-risk group and need special management. However, the recommendation was not clear on the goal for LDL-C levels as there were no trials on whether statins ameliorate CV morbidity and mortality in primary prevention in this specific population. The key point to consider in the choice of ...
Background: Metabolic syndrome prevalence in cardiac rehabilitation (CR) is high and participants have poor baseline and overall improvement in exercise capacity; however, it is unclear if this is due to participant or CR programlevel factors. The purpose of this research was to describe, in CR participants, the association between metabolic syndrome and change in exercise capacity, and to examine exercise capacity variation by CR program. Methods: Data was abstracted from medical charts in four CR programs. A three-category exposure variable was defined as BMI(reference group) and no metabolic syndrome (n=73), BMI ≥ 27 without metabolic syndrome (n=21), and metabolic syndrome (n=156). Hierarchical linear models examined the association between metabolic syndrome and the rate of change in exercise capacity and variation in exercise capacity by CR program. Results: Sixty-two percent of participants had metabolic syndrome. In multivariable analyses, participants with BMI ≥ 27 without metabolic ...
Results. Forty-two patients were followed for 7.1 ± 2.6 years. Eight patients (18.9%) had MCVE. The respective 5- and 10-year MCVE rates were 9.5% and 26.8%. National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III)-defined high-risk status [hazard ratio (HR) 5.02 (95% CI: 1.17-27.4), p = 0.03], BMI , 30 kg/m2 [HR 4.84 (95% CI: 1.46-116), p = 0.02], and plaque detection in the abdominal aorta (p = 0.01) were significantly associated with MCVE. SNV characteristics, corticosteroid maintenance therapy, and C-reactive protein , 5 mg/l were not associated with MCVE. Plaque in the aorta was significantly associated with high-risk status (p , 0.001), while BMI and high-risk status were independent variables. Thus, a BMI , 30 kg/m2 and/or a high-risk status were strongly associated with MCVE (p = 0.004). Carotid intima-media thickness (IMT) identified patients with early MCVE and was correlated with the time to MCVE (r2 = 0.68, p = 0.01). ...