Background: The prevalence of metabolic syndrome (MS) after renal transplantation has yet to be elucidated. In the present study, we investigated the prevalence of MS in Japanese renal transplant recipients.. Methods: A cross-sectional study was conducted to determine the prevalence of MS in 101 renal transplant recipients at Osaka City University Hospital. The prevalence of MS was determined using the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) criteria (modified and original) and the International Diabetes Federation (IDF) criteria.. Results: Using the modified (Japanese) NCEP criteria, a total of 24 out of 101 patients (23.8%) had MS including 21 out of 64 male patients (32.8%) and three out of 37 female patients (8.1%). Using the modified (Asian) NCEP criteria, MS was diagnosed in 23 patients (22.8%); 19 male (29.7%) and four female (10.8%). Using the original NCEP criteria, MS was diagnosed in 15 patients (14.9%); 12 male (18.8%) and three female (8.1%). ...

Thiamine deficiency has suggested to be linked to several insulin-resistance complications. In this study, we aim to associate circulating thiamine levels among cardiometabolic parameters in an Arab cohort using a simple, sensitive, rapid and selective high-performance liquid chromatography (HPLC) method that has recently been developed. A total of 236 randomly selected, consenting Saudi adult participants (166 males and 70 females) were recruited and screened for the presence of the metabolic syndrome (MetS) using the modified National Cholesterol Education Program-Adult Treatment Panel III definition. Blood thiamine and its derivatives were quantified using HPLC. A total of 140 participants (53.9%) had MetS. The levels of thiamine and its derivatives of those with MetS were not significantly different from those without. However, hypertensive subjects had significantly higher urinary thiamine (P = 0.03) as well as significantly lower levels of thiamine diphosphate (TDP) (P = 0.01) and total thiamine

ARTEAGA, ANTONIO et al. Physical activity and cardiovascular risk factors among Chilean young men and women. Rev. méd. Chile [online]. 2010, vol.138, n.10, pp.1209-1216. ISSN 0034-9887. http://dx.doi.org/10.4067/S0034-98872010001100001.. Background: Physical activity (PA) has a protective role in cardiovascular diseases. Aim: To quantify PA in young adults and to correlate it with cardiovascular risk factors. Material and Methods: A cross-sectional study was performed employing the international physical activity questionnaire (IPAQ), to measure the PA of 983 randomly selected young adults from Valparaiso region born between 1974 and 1978. Its results were associated with levels of obesity, insulin resistance and cardiovascular risk factors defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP- ATP III) Results: Mean physical activity among men and women was 3731 ± 3923 and 1360 ± 2303 METs-minutes/week, respectively (p , 0.001). Fifty percent of women and ...

TY - JOUR. T1 - Metabolic syndrome risk factors in relation to aerobic fitness in Japanese middle-aged and elderly people-analysis based on Exercise and physical activity reference for health promotion 2006 (EPAR2006)-. AU - Aoyama, Tomoko. AU - Asaka, Meiko. AU - Ishijima, Toshimichi. AU - Kawano, Hiroshi. AU - Usui, Chiyoko. AU - Sakamoto, Sizuo. AU - Tabata, Izumi. AU - Higuchi, Mitsuru. PY - 2009/6. Y1 - 2009/6. N2 - PORPOSE: This study aimed to compare the prevalence of metabolic syndrome (MS) risk factors and its components in different levels of aerobic fitness established by Exercise and Physical Activity Reference for Health Promotion 2006 (EPAR2006) in Japanese middle-aged and elderly people. METHOD: Men (n=102) and women (n=133), aged 30-69yrs, participated in this study. The prevalence of MS risk factors was evaluated as the number of MS risk factors, according to the diagnostic criterion for Japanese-specific MS. Aerobic fitness was quantified as maximal oxygen uptake (VO2max). ...

Sindroma metabolik (SM) merupakan kelainan kompleks berupa rangkaian faktor berkaitan yang meningkatkan resiko penyakit aterosklerotik kardiovaskuler dan diabetes melitus tipe 2.1 Komponen utama SM berupa peningkatan trig liserida dan High-Density Lipoprotein, peningkatan tekanan darah, gula darah terganggu, peningkatan lingkar pinggang dan resistensi insulin.1,2,3 Reavan dkk pertama kali memberikan konsep dari SM yang awalnya disebut sebagai syndrome X. Setelah itu banyak organisasi internasional dan kelompok ahli seperti, World Health Organization (WHO), European Group for study of Insulin Resistance (EGIR), National Cholesterol Education Program Adult Treatment Panel III (NCEP:ATPIII), American Association of Clinical Endocrinology (AACE), International Diabetes Federation (IDF) dan American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) telah berusaha mengumpulkan semua parameter yang berbeda untuk mendefinisikan SM.1,2 Meskipun telah banyak kemajuan tentang ...

TY - JOUR. T1 - Likelihood of obstructive coronary disease in metabolic syndrome patients with abnormal stress echocardiography. AU - Al Badarin, Firas J.. AU - From, Aaron M.. AU - McCully, Robert B.. AU - Lopez-Jimenez, Francisco. PY - 2011/10/20. Y1 - 2011/10/20. N2 - Background: Metabolic syndrome (MetSx) encompasses several risk factors for macrovascular coronary artery disease. An association between MetSx and coronary syndrome X has also been reported, suggesting that patients with MetSx are more likely to have endothelial dysfunction in the setting of angiographically normal coronary arteries. It remains unknown whether MetSx patients with abnormal stress echocardiography (SE) are more likely to have obstructive coronary disease (CAD) compared to patients without MetSx. Methods: We identified symptomatic patients without known CAD and abnormal SE who underwent coronary angiography within 4 weeks after the SE. Patients were grouped according to their MetSx and impaired fasting glucose ...

Researchers analyzed data from more than 27,000 healthy middle-aged women taking part in the Womens Health Study. They found that 25 percent had metabolic syndrome.. Metabolic syndrome is a cluster of risk factors linked to being overweight or obese. The risk factors are a large waistline, high blood pressure, low HDL (good) cholesterol, high triglyceride levels, and higher-than-normal blood sugar.. In this study, women with three or more of these risk factors were considered to have metabolic syndrome.. During an average of 13 years, 114 of all the women developed PAD. Women with metabolic syndrome had a 62 percent higher risk for PAD than women who did not have metabolic syndrome. Each metabolic syndrome risk factor raised the risk for PAD by 20 percent.. The link between metabolic syndrome and PAD in women was largely explained by increased inflammation. Women with metabolic syndrome had higher levels of two markers of inflammation than their peers who did not have the syndrome.. ...

Introduction: There is little evidence on the association between resistance exercise and incident metabolic syndrome.. Hypothesis: We examined the hypothesis that resistance exercise reduces the risk of developing metabolic syndrome in men.. Methods: Participants were 6,098 men aged 18 to 83 years (mean age, 46) who received an extensive preventive medical examination during 1987-2006, and were free of cardiovascular disease, cancer, and metabolic syndrome at baseline. Resistance exercise was assessed by self-reported muscle strengthening activities using either free weights or weight training machines. We used the frequency of resistance exercise (0, 1, 2, 3, 4, and ≥5 days/week) as our main exposure categories. Metabolic syndrome was defined as the presence of ≥3 of the following criteria: waist circumference ,102 cm, triglycerides ≥150 mg/dL, high-density lipoprotein cholesterol ,40 mg/dL, systolic/diastolic blood pressure ≥130/85 mm Hg or physician-diagnosed hypertension, and ...

The purpose of the study is to evaluate the blood pressure lowering effect and safety of aliskiren in combination with Hydrochlorothiazide (HCTZ) compared to aliskiren monotherapy when given to metabolic syndrome patients with stage 2 systolic hypertension (mean sitting systolic blood pressure [msSBP] ≥ 160 mm Hg and , 200 mm Hg ...

1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285(19): 2486-2497. 2. Grundy SM, Hansen B, Smith SC et al. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 2004; 109(4): 551-556. 3. Griffin BA, Freeman DJ, Tait GW et al. Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis 1994; 106(2): 241-253. 4. Arsenault BJ, Lemieux I, Despres JP et al. The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results ...

The objective of this systematic review were to determine the effectiveness of lifestyle interventions on the prevalence of metabolic syndrome and on independent, modifiable risk factors for metabolic syndrome in people with metabolic syndrome. Randomised controlled trials published in English that evaluated the effectiveness of supervised, multifaceted lifestyle interventions in people with metabolic syndrome were included. Lifestyle interventions were defined as any supervised intervention involving both diet and exercise with or without other components, such as counselling. The risk of bias of the included trials was assessed using the PEDro scale, and these were used to determine the quality of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Outcomes were prevalence of metabolic syndrome, risk factors for metabolic syndrome (eg, waist circumference, triglycerides, systolic blood pressure, body mass index), and quality of life. ...

Metabolic syndrome substantially increases risk of cardiovascular events. It is therefore imperative to develop or optimize ways to prevent or attenuate this condition. Exercise training has been long recognized as a corner-stone therapy for reducing individual cardiovascular risk factors constituting the metabolic syndrome. However, the optimal exercise dose and its feasibility in a real world setting has yet to be established. The primary objective of this randomized trial is to investigate the effects of different volumes of aerobic interval training (AIT) compared to the current exercise guideline of moderate-intensity continuous training (MICT) on the composite number of cardiovascular disease risk factors constituting the metabolic syndrome after a 16 week, 1-year, and 3-year follow-up. This is a randomized international multi-center trial including men and women aged ≥30 years diagnosed with the metabolic syndrome according to the International Diabetes Federation criteria. Recruitment began in

Metabolic syndrome (also called Syndrome-X) is not a medical diagnosis itself but a group of five risk factors. These factors are increasing your risk of heart disease, stroke and type 2 diabetes. In their turn these conditions may lead to blood pressure (greater than 130/85mmHg), high blood sugar (insulin resistance), excess body fat around the waist, and imbalanced cholesterol control or triglyceride levels (HDL).. Having one of the issues doesnt mean you have metabolic syndrome. Doctors usually diagnose that when you have 3 of them. Metabolic syndrome is increasingly common nowadays among adults. If you have metabolic syndrome or any of its components, aggressive lifestyle changes can prevent the development of serious health problems. ...

Background To examine the relationship between the metabolic syndrome and its components and gait speed among older U.S. men and women. Whether these associations are independent of physical activity was also explored. Methods Eight hundred and thirty-five men and 850 women aged ≥50 years from the continuous National Health and Nutrition Examination Survey 1999-2002 were examined. We used the definition of the metabolic syndrome developed by the U.S. National Cholesterol Education Program Adult Treatment Panel III. Gait speed was measured with a 6.10-meter timed walk examination. Results The prevalence of the metabolic syndrome was 40.2% in men and 45.6% in women (P = .127). The prevalence of gait speed impairment was 29.3% in men and 12.5% in women (P < .001). No association was found between the metabolic syndrome and gait speed impairment. After including the individual components of the metabolic syndrome in a logistic model adjusted for age and leisure-time physical activity, abdominal ...

People who undergo blood testing to find out whether they have metabolic syndrome are likely to be worried about their heart health. However, new research from the University of Wisconsin School of Medicine and Public Health suggests that metabolic syndrome may also be harmful to the brain ...

Our objective was to perform a quantitative review of prospective studies examining the association between the metabolic syndrome and incident diabetes.,Using the title terms diabetes and metabolic syndrome in PubMed, we searched for articles published since 1998.,Based on the results from 16 cohorts, we performed a meta-analysis of estimates of relative risk (RR) and incident diabetes. The random-effects summary RRs were 5.17 (95% CI 3.99-6.69) for the 1999 World Health Organization definition (ten cohorts); 4.45 (2.41-8.22) for the 1999 European Group for the Study of Insulin Resistance definition (four cohorts); 3.53 (2.84-4.39) for the 2001 National Cholesterol Education Program definition (thirteen cohorts); 5.12 (3.26-8.05) for the 2005 American Heart Association/National Heart, Lung, and Blood Institute definition (five cohorts); and 4.42 (3.30-5.92) for the 2005 International Diabetes Federation definition (nine cohorts). The fixed-effects summary RR for the 2004 National Heart, ...

Metabolic syndrome prevalence is increased in rheumatoid arthritis patients and is associated with disease activity.: MetS frequency was higher in RA patients t

The lack of previous studies about metabolic syndrome in Bolivia makes it interesting to know the actual situation in one of the poorest country in South America. The number of patients was not the ideal to try to show the prevalence in the entire country, but it would be an initial point for future studies.. The economical situation was an important determinant factor in our study since many obese children were not included because of lack of enough money for medical visits and some of the diagnostic test that were not financed by research committee of the hospital.. Insulin resistance was found in 39.4% of obese children and adolescents. This rate is similar as other found in studies conducted in developing countries like France, Italy, Spain and United States of America. [15-19]. There are no clear definition for metabolic syndrome in children and adolescents, existing different criteria used according to the place or population of the study. [20-24] NCEP-ATP III definition with modified ...

Metabolic syndrome is a condition that includes the presence of a cluster of risk factors specific for cardiovascular disease.. Metabolic syndrome significantly raises the risk of developing diabetes, heart disease, and/or stroke.. Most people who have metabolic syndrome have insulin resistance.. The body makes insulin to move glucose (sugar) into cells for use as energy.. Obesity, commonly found in persons with metabolic syndrome, makes it more difficult for cells to respond to insulin.. If the body cannot make enough insulin to override the resistance, the blood sugar level increases and diabetes can result. Metabolic syndrome may be a beginning of the development of type 2 diabetes.. Because metabolic syndrome and insulin resistance are closely associated, many healthcare professionals believe that insulin resistance may be a cause of metabolic syndrome.. However, a direct link between the two conditions has not been established.. Others believe that hormone changes, caused by chronic stress, ...

MORENO-FRANCO, Belén et al. Association between daily sitting time and prevalent metabolic syndrome in an adult working population: the AWHS cohort. Nutr. Hosp. [online]. 2015, vol.32, n.6, pp.2692-2700. ISSN 1699-5198. http://dx.doi.org/10.3305/nh.2015.32.6.9806.. Objective: the aim of this analysis was to measure the association between daily sitting time and prevalent metabolic syndrome, independently of the physical activity performed. Subjects and methods: the Aragon Workers Health Study cohort consists of 5 865 participants from which a sample of 1 415 male participants (40-55 years old) with completed data at baseline was selected. Sitting time and physical activity were assessed by validated questionnaires, and the socio-demographic, clinical and biochemical covariates needed to diagnose metabolic syndrome were collected as part of the study protocols. Metabolic syndrome was defined according to the modified National Cholesterol Education Program - Adult Treatment Panel III. Multiple ...

In this prospective study, we documented that the 10-year cumulative incidence of type 2 diabetes was 17.5% in the Aboriginal study population. We also noted that the incidence increased with age, from 10.5% among participants 10-19 years old, to 43.3% among those 40-49 years. High adiposity, dyslipidemia, hyperglycemia, hyperinsulinemia and hypertension at baseline were associated with increased risk of diabetes after adjustment for age and sex. Although metabolic syndrome at baseline had low sensitivity and low positive predictive value for detecting future diabetes, it had high specificity and high negative predictive value for correctly identifying disease-free individuals at follow-up. In addition, metabolic syndrome at baseline was associated with incident diabetes to the same degree that impaired glucose tolerance was.. Similar observations were reported in the Strong Heart Study, a cohort study that followed Aboriginal North Americans aged 45-74 years with a high prevalence of diabetes ...

How does the metabolic syndrome affect stroke risk?. Metabolic syndrome increases the risk of stroke in all ethnic groups and both sexes. Having the metabolic syndrome approximately doubles your risk of having a stroke compared with healthy persons, and the syndrome is estimated to account for 30% of all blocked-vessel (ischemic) strokes in women. Nearly half of all strokes occur in people who have the metabolic syndrome.. Each component of the metabolic syndrome increases your risk of a first or repeat blocked-vessel stroke. The more of these components you have, the higher your risk of developing stroke. High blood pressure, high cholesterol, and low HDL (good) cholesterol are all individual risk factors for atherosclerosis, meaning they can cause fatty deposits (plaque) to build up on the walls of your blood vessels and reduce blood flow to the brain. In a study of 1895 adults (59% were women), the metabolic syndrome increased by 36% the risk of developing plaque in the carotid arteries in ...

Background: We aimed to assess the burden of metabolic syndrome (MetS), and evaluate the phenotypic variation of MetS in a population at high risk for diabetes in urban Karachi, Pakistan. Methods: This study was embedded in a lifestyle intervention trial for the prevention of type 2 diabetes mellitus. The study population comprised participants who belonged to urban households in Karachi, Pakistan. Results: Among 15,590 individuals who were screened through diabetes risk score (DRS), 3945 individuals met the criteria for a high DRS (≥60). After excluding 1780 participants due to refusals and ineligibility, 2165 were enrolled, a total of 1188 subjects (54.9%) met the International Diabetes Federation criteria for MetS, and a total of 1199 subjects (55.4%) participants met the US National Cholesterol Education Program. Raised serum triglycerides (TGs) and low high-density lipoprotein (HDL) cholesterol were significantly associated with MetS. On multivariate logistic regression, higher body mass index

Background: The prevalence of metabolic syndrome (MetS) is growing rapidly in China. Tai chi and dancing are common types of exercise among middle-aged and elderly Chinese. It remains unclear whether these activities are associated with a lower risk of MetS. Methodology/Principal Findings A total of 15,514 individuals (6,952 men, 8,562 women) aged 50 to 70 years from the Dongfeng-Tongji Cohort in Shiyan, China participated in a cross-sectional study. Physical activity and other lifestyle factors were assessed with semi-structured questionnaires during face-to-face interviews. MetS was defined by the current National Cholesterol Education Program/Adult treatment Panel III criteria for Asian Americans. The prevalence of MetS was 33.2% in the study population. In the multivariable-adjusted logistic regression analyses, total physical activity levels were monotonically associated with a lower odds of MetS [OR 0.75 comparing extreme quintiles, 95% confidence interval (CI) 0.66-0.86, P,0.001]. ...

Eur J Gastroenterol Hepatol. 2014 Mar 17. [Epub ahead of print]. Aziz H1, Gill U, Raza A, Gill ML.. Abstract. INTRODUCTION: Hepatitis C viral (HCV) infection is caused by an RNA virus. HCV infection is considered to induce systemic disease that causes steatosis, alters lipid metabolism, and results in metabolic syndrome. This study aimed to investigate the therapeutic outcome in HCV genotype 3 patients with metabolic syndrome.. MATERIALS AND METHODS: A total of 621 HCV-positive patients who visited the hospital for treatment were screened. Among these, 441 patients were enrolled for antiviral therapy. These enrolled patients were assessed for metabolic syndrome according to the International Diabetes Federation criteria. Group A included patients with metabolic syndrome and group B included patients without metabolic syndrome. All patients received peginterferon-α2a (180 μg/week) and ribavirin (10 mg/kg/day) for 6 months.. RESULTS: The prevalence of metabolic syndrome in chronic HCV patients ...

Introduction: Because of the high prevalence of the metabolic syndrome in Iran, this study used factor analysis to examine how the major components of the metabolic syndrome relate to each other and the role of hyperlipidemia in Iranian subjects. Materials and Methods: 8990 subjects aged over 18 years, participants of ...

Cardiometabolic syndrome treatment center in Indianapolis, IN. Discover what is cardiometabolic syndrome, learn the symptoms, and find proper treatment of Cardiometabolic Syndrome.

Cardiometabolic syndrome treatment center in Clearwater, FL. Discover what is cardiometabolic syndrome, learn the symptoms, and find proper treatment of Cardiometabolic Syndrome.

One of the most interesting facts about metabolic syndrome is that it was introduced in medical textbooks very recently, in 1998 and its causes are still being researched. Other names for metabolic syndrome include syndrome X, insulin resistance syndrome, and American syndrome. However, this condition is very widespread, some experts estimating that it is as common as acne and the common cold. In the United States, more than 45 million people have it. One in six people is expected to develop metabolic syndrome at one point in their lives, especially after the age of 65. In the past years, the incidence of metabolic syndrome has increased, one possible cause being the rise in obesity rates. At present, it is estimated that almost 35% of Americans suffer from metabolic syndrome. Nearly half the instances of metabolic syndrome occur in people over the age of 60.. ...

#Obesity#Metabolic Syndrome - Metabolic are the biochemical processes that are involved in the normal functioning of your body. Risk factors are common traits, habits or conditions that raise your risk of developing a disease. Metabolic syndrome is the term used for a group of factors that increase your risk of developing the cardiac diseases and other health issues, like stroke and diabetes. Metabolic syndrome is becoming a prevalent disorder due to a sharp rise in the rate of obesity among adults. Metabolic syndrome may soon overtake smoking as the dominant risk factor responsible for heart disorders. The following are some of the dominant symptoms of metabolic syndrome: -Abdominal obesity -A high level of Triglyceride( 150 and higher) -A lowered level of HDL (good cholesterol) -Blood pressure of 130/85 and above -Increased level of blood sugar (fasting) of 110 or more It is not impossible to prevent the onset of metabolic syndrome. Slight lifestyle alterations can help to delay the

TY - CONF. T1 - Influence of metabolic syndrome on clinic and 24-h pulse pressure in essential hypertension.. AU - Mulè, G. AU - Cerasola, Giovanni. AU - Cottone, Santina. AU - Mule, Giuseppe. AU - Nardi, Emilio. AU - Cusimano, Paola. AU - Palermo, Alessandro. PY - 2007. Y1 - 2007. KW - metabolic syndrome, pulse pressure, hypertension. UR - http://hdl.handle.net/10447/37764. M3 - Paper. ER - ...

Continuous and dichotomous metabolic syndrome definitions in youth predict adult type 2 diabetes and carotid artery intima media thickness: the Cardiovascular Risk in Young Finns Study

Metabolic syndrome (MetS) is purportedly related to risk of developing colorectal cancer; however, the association of MetS, as defined according to recent international criteria, and colorectal cancer has not been yet evaluated. In particular, it remains unclear to what extent the MetS components individually account for such an association. We addressed these issues in a nested case-control study that included 1,093 incident cases matched (1:1) to controls by using incidence density sampling. Conditional logistic regression was used to estimate relative risks (RR) and 95% CIs. MetS was defined according to the criteria of the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII), the International Diabetes Federation (IDF), and the 2009 harmonized definition. Among individual components, abdominal obesity (RR = 1.51; 95% CI: 1.16-1.96) was associated with colon cancer, whereas abnormal glucose metabolism was associated with both colon (RR = 2.05; 95% CI: 1.57-2.68) and rectal

Although aspects of diet have been linked to individual metabolic features of the metabolic syndrome (2,3,17,18), the role of dietary factors in the etiopathogenesis of this syndrome has been poorly investigated (20). As far as type 2 diabetes is concerned, conflicting relationships with carbohydrates and fat intake have been reported (28,29). Grouping diseases that share a common etiopathogenetic basis was an attempt to clarify the relationships of the insulin resistance syndrome with dietary factors. We had an opportunity to study a population of Japanese ancestry that was shown to be highly susceptible to metabolic syndrome when exposed to the Western world (30). Since 1993, our group has followed a cohort of Japanese Brazilians with high prevalence of central obesity, diabetes, dyslipidemia, and hypertension (8,9,12).. The definition of metabolic syndrome used in the present study introduced a modification to the National Cholesterol Education Program criteria with respect to the waist ...

Metabolic syndrome (MetS) is a cluster of conditions that conjoined represents a 1.5-2.5 fold increased risk of developing cardiovascular disease (CVD). Recent studies have reported that gut dysbiosis and leakage of bacterial components, may contribute to the metabolic disturbances and systemic inflammation observed in subjects with MetS. Chronic exposure to lipopolysaccharide (LPS) has been shown to induce features of MetS in experimental studies. LPS interacts with the innate immune system, facilitated through LPS-binding protein (LBP) and the co-receptor CD14, both regarded as markers of gut leakage. We investigated whether circulating levels of LBP and sCD14 are associated with the presence of MetS and its components, and further any association with systemic inflammation. We examined 482 men, aged between 65 and 75 years, all at high CVD risk. MetS criterias according to the US National Cholesterol Education Program Adult Treatment Panel III were met in 182 subjects (38%). Levels of LBP and sCD14

Forty-four participants were phenotyped according to BMI as non-obese vs obese (,30 or ,30 kg/m2) and according to the International Diabetes Federation criteria of MetS: ≤2 criteria MetS (MetS−) vs ≥3 criteria MetS (MetS+); (1.)non-obese MetS− vs (2.) non-obese MetS+ and (3.) obese MetS− vs (4.) obese MetS+. Flow-mediated dilation (FMD), body composition including liver fat (MRI and spectroscopy), dietary intake, intensities of habitual physical activity and cardio-respiratory fitness were determined. Variables were analysed using a one-factor between-groups ANOVA and linear regression; mean (95% CI) are presented. ...

People with schizophrenia have a higher risk of metabolic syndrome (also referred to as syndrome X or the dysmetabolic syndrome) than the general population. Metabolic syndrome is a cluster of related symptoms that puts the individual at increased risk of diabetes and cardiovascular disease such as heart-attack and stroke. Metabolic syndrome generally includes some or all of the following: elevated blood pressure, abdominal obesity, diabetes or prediabetes (impaired glucose tolerance, impaired fasting glucose or insulin resistance), dyslipidemia (high levels of triglycerides and/or HDL - the bad cholesterol), and inflammatory markers. It is the leading natural cause of increased rate of death in people with schizophrenia. An article by Dr. Jonathan M. Meyer, MD in the Psychiatric Times summarizes new findings exploring the link between metabolic syndrome and schizophrenia, and presents recent consensus recommendations for preventing and monitoring metabolic syndrome or dysfunction. He ...

RESEARCH DESIGN AND METHODS This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups. ...

INTRODUCTION: the aim of this study was to investigate the prevalence of metabolic syndrome in Sokoto metropolis of North-Western Nigeria. METHODS: a cross-sectional community based study was carried out. Four hundred and ten subjects (201 males and 209 females) were recruited for the study using a multi-stage sampling technique. Demographic and the life style data was obtained from the participants. Evaluation of anthropometric variables, fasting blood sugar, lipid profiles, insulin resistance and blood pressure was performed. The classification of metabolic syndrome was based on the NCEP ATP III guidelines. RESULTS: the mean (SD) age of the sample population was 39.6 (14.4) years. The mean (SD) age of the male subjects was 38.4(14.9) years and that of the females was 40.8(13.9) years (p> 0.05). The overall prevalence of metabolic syndrome was 35.1% with the females having 42.83% and the males 27.36%. The frequencies of metabolic syndrome parameters in the study subjects were low HDL (56.1%),

There are other names for metabolic syndrome, which include syndrome X, insulin resistance syndrome, metabolic syndrome X and cardiometabolic syndrome.. Research studies have shown a definite connection between high triglycerides, metabolic syndrome and the development of diseases and conditions such as Type 2 diabetes, heart and vascular diseases, and fatty liver. Research also shows that the incidence of metabolic syndrome has risen over 10% since 1988.. Metabolic Syndrome and Liver Cancer. In its recent study, the National Cancer Institute discovered that people who have metabolic syndrome may be more likely to develop liver cancer. The study examined the medical histories of people diagnosed with liver cancer. The data was then compared to the medical histories of healthy people. The results? More than 37% of those with liver cancer had pre-existing metabolic syndrome compared to 17.1% of healthy people with the syndrome.. Sadly, along with the rise of high triglycerides, and the increase in ...

This study involved high-intensity aerobic-interval training. For more bang for you time one can obtain the positive heart benefits, have a positive effect on your metabolism, and also increase strength at the same time with high intensity interval strength training. High intensity interval strength training can increase metabolism four ways.. The type of strength training we do at New Orleans Fitness Trainers and atAustin Fitness Trainers is high intensity interval training (HIIT). It is a full body workout where a series of strength training exercises are performed with little rest between the exercises. Strength training has more to offer than stronger muscles and bones; it is a heart healthy and beneficial to your metabolism as well. ...

Epicardial fat is true visceral fat deposited around sub epicardial coronary vessels; it has been implicated in the development of coronary atherosclerosis. Epicardial fat has been also associated with insulin resistance. Trans thoracic echocardiography provides a reliable measurement of epicardial fat thickness. Objective: To evaluate the association between epicardial fat thickness with metabolic syndrome and anthropometric parameters of adiposity. Methods: We assessed 70 patients who underwent echocardiography; the epicardial fat thickness on the free wall of the right ventricle was measured at end-diastole from the parasternal long-axis views of 3 cardiac cycles with Aloka Alfa 6 equipment (Japan), by 2 cardiologists who were unaware of the clinical data. Metabolic syndrome was defined according with the International Diabetes Federation criteria. The association between epicardial fat thicknesses with metabolic syndrome was evaluated with the fisher exact test, whereas its correlation with body

The study is a Phase-I like double blind randomized placebo controlled crossover design trial. The objective is to assess the dose response relationship on glycemic and vascular effects of an acutely administered Korean White Ginseng (KWG)(Panax C.A. Meyer) in individuals with metabolic syndrome or type 2 diabetes . Twenty seven subjects with Type 2 Diabetes (Key inclusion criteria: HbA1c ≤8.5%)or metabolic syndrome (Key inclusion criteria: as defined by The US National Cholesterol Education Program Adult Treatment Panel III)will be recruited for the study ...

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Metabolic syndrome is difficult to reverse in humans. Symptoms include abdominal obesity, high cholesterol levels, high blood pressure, and inability of the body to use insulin and glucose properly. The result of metabolic syndrome greatly increases risk of diabetes, stroke, and heart attack. Kudzu root could help lower risk factors among individuals diagnosed with metabolic syndrome.. An estimated 50 million Americans suffer from metabolic syndrome as the result genetic predisposition, inactivity and poor dietary habits. Excess abdominal fat is a contributing factor for developing metabolic syndrome. Women whose waist circumference is greater than 35 inches, and men with waist size greater than 40 inches are at risk for health complications from metabolic syndrome. Kudzu could be further developed as a natural defense against heart disease and stroke.. The study authors write, kudzu root may provide a dietary supplement that significantly decreases the risk and severity of stroke and ...

PCa and BPH, both chronic diseases with slow progression, are significant health concerns and become more common in older men.. PCa is the leading cause of non-skin cancer among men worldwide and in the USA it is the second leading cause of cancer deaths (after lung cancer).. Symptomatic BPH represents the most common urologic disease among elderly males, affecting about one-quarter of men in their 50s, one-third of men in their 60s, and about half of 80 year olds.. Metabolic syndrome is a complex, very common disorder and considered a worldwide epidemic. It is already known to be directly associated with an increase in the risk of coronary artery disease, cardiovascular atherosclerotic diseases and type 2 diabetes.. The main components of metabolic syndrome are:. ...

Shafie, Siti Raihanah binti (2017) Saturated fatty acids, linseed components and high amylose wheat in attenuation of diet-induced metabolic syndrome. [Thesis (PhD/Research)] ...

Blueberries were associated with an improvement in cardiometabolic function in those with metabolic syndrome, new study results suggested.

TY - JOUR. T1 - Targeting the consequences of the metabolic syndrome in the diabetes prevention program. AU - Goldberg, Ronald B.. AU - Mather, Kieren. PY - 2012/9/1. Y1 - 2012/9/1. N2 - This review describes the effect of lifestyle change or metformin compared with standard care on incident type 2 diabetes and cardiometabolic risk factors in the Diabetes Prevention Program and its Outcome Study. The Diabetes Prevention Program was a randomized controlled clinical trial of intensive lifestyle and metformin treatments versus standard care in 3234 subjects at high risk for type 2 diabetes. At baseline, hypertension was present in 28% of subjects, and 53% had metabolic syndrome with considerable variation in risk factors by age, sex, and race. Over 2.8 years, type 2 diabetes incidence fell by 58% and 31% in the lifestyle and metformin groups, respectively, and metabolic syndrome prevalence fell by one-third with lifestyle change but was not reduced by metformin. In placebo-and metformin-treated ...

When a mans penis works properly, everything is right with the world. When erectile dysfunction damages ugly heads, the world is no longer bright and cheerful. Of course no one welcomes erectile dysfunction, but sometimes this can be a wake-up call for issues outside of penis health. For example, in some cases this problem may be an indication of a possible metabolic syndrome.. About metabolic syndrome Although it is often called condition, metabolic syndrome is a term used to refer to the encounter of several different conditions. Generally, it occurs when a person has chronic high blood pressure; control high bad cholesterol levels; control low good cholesterol; maintaining a high sugar count; and tend to have too much fat around the middle. When someone has at least three of these conditions, he is said to have metabolic syndrome, which puts people at risk for heart disease, stroke and diabetes.. Although the term metabolic syndrome is unfamiliar to the general public, it is not ...

EVIDENCE SYNTHESIS: We included data from 17 articles with an aggregate of 28,939 participants, among whom 3791 were psoriasis patients. Overall, the studies reported a higher prevalence of metabolic syndrome in patients with psoriasis. The odds ratio (OR) for metabolic syndrome and psoriasis ranged from 1.39-4.49, and the adjusted OR ranged from 1.29 to 5.14. The studies reported a higher prevalence of the individual components of metabolic syndrome in patients with psoriasis. A dose-response relationship was observed between psoriasis severity and the prevalence of metabolic syndrome. Due to the scarcity of cohort studies, it is difficult to fully examine the impact of psoriasis on the development of metabolic syndrome. Variability in how outcomes were recorded existed among some studies, which made between-study comparisons difficult ...

BackgroundEpidemiological studies suggest that the Mediterranean diet (MedDiet) may reduce the risk of developing the metabolic syndrome (MetS). We compared the

TY - JOUR. T1 - Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study. AU - Camma, Calogero. AU - Petta, Salvatore. AU - Craxi, Antonio. AU - Eslam, Mohammed. AU - Rosso, Chiara. AU - Porzio, Marianna. AU - Bugianesi, Elisabetta. AU - Valenti, Luca. AU - Fargion, Silvia. AU - George, Jacob. AU - Barbara, Marco. PY - 2017. Y1 - 2017. N2 - Background & Aims: Metabolic syndrome (MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease (NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods: We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results: Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein (HDL) ...

Metabolic syndrome is defined as a cluster of risk factors that can raise the risk of other health conditions, such as type 2 diabetes, heart disease, and stroke.. Risk factors include abdominal obesity, low levels of high-density lipoprotein (HDL) cholesterol - or good cholesterol - high triglyceride levels, high blood pressure, and high fasting blood sugar.. The presence of at least three of these risk factors warrants a diagnosis of metabolic syndrome.. According to the American Heart Association, metabolic syndrome affects around 23 percent of adults in the United States.. Adopting a healthful diet is considered one of the best ways to prevent or treat metabolic syndrome. The new review - recently published in the journal Phytotherapy Research - suggests that avocados should form a part of this diet.. Avocados are a fruit from the avocado tree, or Persea americana, which is native to Mexico and Central and South America.. A number of studies have documented the possible health benefits of ...

Obesity is a health disorder characterized by an increase in body weight, measured by waist circumference. High waist circumference is linked to potential development of non-communicable diseases. A systematic review study was used to explore health risks of high waist circumference through Google Scholar, Science Direct, Pubmed, and Proquest. Findings show that high waist circumference increased the risks of developing hypertension, type 2 diabetes mellitus, hypercholesterolemia, joint pain, low back pain, and hyperuricemia. It is recommended that government increase their role in raising public awareness to maintain healthy lifestyle.. ...

LDL-C level at baseline was higher in the high risk group (4.11±1.06 mmol/L) compared to low and moderate risk groups (3.68±0.89, 3.42±1.15). In high risk patients, 22/51(43%) reached LDL-C target of ,2.60 mmol/L. In the moderate risk group, 4/8(50%) reached LDL-C target of ,3.40, and in the low risk group, 18/20 (90%) achieved LDL-C target of ,4.10.. ALT was available for 83(52%) pre-index, 101(63%) post-index and for 49(31%) pre and post-index. Compared to baseline, ALT did not change significantly post-treatment with simvastatin (from 24±19 to 23±20). CK measurements were available in 4(2.5%) pre-index with mean 79±39 IU/L, 6(3.7%) post-index with mean 102±56 IU/L and no documentation for pre and post-index.. DISCUSSION National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) sets LDL-C as the primary target for cholesterol lowering therapy. LDL-C should be lowered to ,2.60 mmol/L in patients with established CAD or CAD risk equivalents like DM and other CVDs.12 ...

New Haven Connecticut Internist Doctors physician directory - Metabolic syndrome risk factors include high blood pressure, obesity, high cholesterol, and insulin resistance. Prevention and treatment include lifestyle changes such as diet, exercise, and medication.

The metabolic syndrome, a concurrence of disturbed glucose and insulin metabolism, overweight and abdominal fat distribution, mild dyslipidemia, and hypertension, is associated with subsequent development of type 2 diabetes mellitus and cardiovascular disease (CVD). .... The prevalence of the metabolic syndrome ranged from 8.8% to 14.3%, depending on the definition. There were 109 deaths during the approximately 11.4-year follow-up, of which 46 and 27 were due to CVD and CHD, respectively. Men with the metabolic syndrome as defined by the NCEP were 2.9 (95% confidence interval [CI], 1.2-7.2) to 4.2 (95% CI, 1.6-10.8) times more likely and, as defined by the WHO, 2.9 (95% CI, 1.2-6.8) to 3.3 (95% CI, 1.4-7.7) times more likely to die of CHD after adjustment for conventional cardiovascular risk factors. The metabolic syndrome as defined by the WHO was associated with 2.6 (95% CI, 1.4-5.1) to 3.0 (95% CI, 1.5-5.7) times higher CVD mortality and 1.9 (95% CI, 1.2-3.0) to 2.1 (95% CI, 1.3-3.3) times ...

Abstract:Background: The metabolic syndrome comprises an array of cardiovascular disease (CVD) risk; the clustering of CVD risk factors in the metabolic syndrome suggests a common underlying mechanism. Circulating serum sialic acid, an inflammatory marker has recently been shown to be a strong predictor of cardiovascular mortality, and obesity-related diseases. Objective: is to study the relationship between serum total sialic acid and metabolic variables in type 2 diabetes with and without metabolic syndrome.Subject and Methods: One hundred type 2 diabetic mellitus patients (52 of them had metabolic syndrome and 48 without it) were recruited from the National Diabetic Center, Al-Mustansiriya University during the period from June 2011 to January 2012. One hundred apparently healthy control matched for age and sex were participated in this study. Fasting venous blood samples were collected from all participants, the level of HbA1c was estimated by high performance liquid chromatography. Total ...

Title:Free Fatty Acids: Circulating Contributors of Metabolic Syndrome. VOLUME: 16 ISSUE: 1. Author(s):Chase Suiter, Santu K. Singha, Rozita Khalili and Zia Shariat-Madar*. Affiliation:Department of Biomolecular Sciences Division of Pharmacology, The University of Mississippi, Mississippi 38677-1848, Department of Biomolecular Sciences Division of Pharmacology, The University of Mississippi, Mississippi 38677-1848, Department of Biomolecular Sciences Division of Pharmacology, The University of Mississippi, Mississippi 38677-1848, Department of Biomolecular Sciences Division of Pharmacology, The University of Mississippi, Mississippi 38677-1848. Keywords:Cardiovascular disease, free fatty acids, metabolic syndrome, morbidity, mortality, monosaturated fatty acids.. Abstract:Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly, the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical studies indicate that ...

Vegetarians have experienced a much lower risk of metabolic syndrome than non-vegetarians, according to researchers at Loma Linda University in California.. Their findings are based on analysis of more than 700 adults randomly sampled from a long-term study of the lifestyle and health of almost 100,000 Seventh-day Adventist Christians across the United States and Canada.. It has been found in the study that 25 percent of vegetarians had metabolic syndrome, then the number considerably increases to 37 percent for semi vegetarians and 39 percent for non vegetarians. The study is published in the April issue of the journal Diabetes Care.. The risk of developing metabolic syndrome is 36 percent lower among vegetarians than non- vegetarians. This means that vegetarians are less likely to develop heart disease, diabetes and stroke - three major conditions that are closely linked with metabolic syndrome, the researchers say.. The study also found that vegetarians, though slightly older than ...

Rationale The aim of this study is to determine the relationship between metabolic syndrome and the extent of coronary artery disease (CAD) in young adults presenting with acute coronary syndrome. Background Metabolic syndrome is associated with subsequent development of type II diabetes mellitus and cardiovascular disease. Individuals with metabolic syndrome are at a higher risk of developing myocardial infarction and CAD. Patients and methods This study was carried out at Kasr Al Ainy Hospital at Cairo University and the Sohag Specialized Cardiac and Digestive System Center. One hundred and twenty-two patients presented with acute coronary syndrome during the period of the study from January 2011 to January 2012. Eighty-five were men (69.7%) and 37 were women (30.3%). Patients were classified into two groups according to the presence or absence of metabolic syndrome to determine the effect of metabolic syndrome on severity of coronary lesions in comparison with nonmetabolic patients. ...

INTRODUCTION. Clinical importance of non-alcoholic fatty liver disease NAFLD has grown in recent years, mainly in consequence of the obesity epidemics, sedentary habits and high calorie diet adopted by people of Western countries, reflecting the increase in cardiovascular and endocrine-metabolic diseases(30). It has been considered the most common liver disease and the most frequent cause of elevated aminotransferase and cryptogenic cirrhosis(19, 20, 21). The prevalence of NAFLD has been estimated in 2.8% to 88%, depending on population and investigative methods(2, 7, 9, 19, 21, 48). NAFLD refers to fat accumulation, mainly triglycerides, in hepatocytes so that it exceeds 5% of the liver weight(2). Available data from clinical, experimental and epidemiological studies describe the NAFLD as the hepatic manifestation of metabolic syndrome (MS)(59). Main risk factors associated with metabolic syndrome are abdominal obesity, insulin resistance, diabetes and dyslipidemia(73). Interestingly, NAFLD can ...

This open, controlled study evaluated the effects of 6 month supplementation with Pycnogenol maritime pine bark extract on health risk factors in subjects with metabolic syndrome. Pycnogenol was used with the aim of improving risk factors associated with metabolic syndrome, central obesity, elevated triglycerides (TG), low HDL cholesterol, high blood pressure and fasting blood glucose. Sixty-four subjects (range 45-55 years) presenting with all five risk factors of metabolic syndrome were included, and Pycnogenol was administered for 6 months. A group of 66 equivalent subjects were followed up as controls. In the 6-month study Pycnogenol supplementation 150 mg/day decreased waist circumference, TG levels, blood pressure and increased the HDL cholesterol levels in subjects. Pycnogenol lowered fasting glucose from baseline 123 ± 8.6 mg/dl to 106.4 ± 5.3 after 3 months and to 105.3 ± 2.5 at the end of the study (p , 0.05 vs controls). Mens waist circumference decreased with ...

We have demonstrated previously that both acute and chronic oral administration of adenosine have novel functions such as anti-hypertensive effects and improved hyperlipidaemia in stroke-prone spontaneously hypertensive rats (SHRSP) fed a normal diet. The purpose of the present study was to investigate the effect of adenosine administration on metabolic syndrome-related parameters in SHRSP fed a high-fat diet. Six-week-old rats were divided into three groups, and were administered either water (control) or adenosine (10 or 100 mg/l) for 8 weeks. During this period, the rats had free access to a high-fat diet based on AIN-93M. The results showed that hypertension, plasma lipid, NO, insulin, glucose and urinary 8-hydroxy-2-deoxyguanosine levels improved significantly in both adenosine groups. The mRNA expression levels of genes involved in anti-oxidative activity and adenosine receptors were also altered in the adenosine groups. Administration of adenosine also increased plasma adiponectin ...

Hypertension is a major global public health problem due to its related high morbidity and mortality especially in developing countries, with a prevalence of 46% in the adult population. The study was aimed at investigating the prevalence of metabolic syndrome among hypertensive outpatients and its associated effect on target organs. Questionnaire was administered to 150 hypertensive outpatients and 50 non-hypertensives. Anthropometrics such as body mass index, waist circumference, body fat, visceral fat, blood pressure and biochemical parameters including lipid profile, urea, AST, ALT, and coronary risk were determined using standard procedures. Dietary pattern of hypertensives was not different from non-hypertensives. Metabolic syndrome was found to be significantly prevalent among hypertensive group than non-hypertensive group. Among cardiovascular disease markers, high coronary disease risk was significantly higher among participants with metabolic syndrome compared to those without ...

INVESTIGATORS: Rudy Ortiz, PhD. STUDY LOCATION: University of California, Merced. PROJECT TITLE: Effects of CBD on blood pressure and substrate metabolism during metabolic syndrome. FUNDING SOURCE: Center for Medicinal Cannabis Research. PROJECT TYPE: Pre-Clinical Study. STATUS: Pending. ABSTRACT:. Cardiovascular disease (CVD) is the leading cause of death in the US (1), and is a primary outcome of metabolic syndrome (MetS). Metabolic syndrome is defined by the simultaneous presence of multiple maladies that include hypertension and glucose intolerance. MetS is also a leading cause of the development of type 2 diabetes mellitus (T2DM), an additional metabolic disorder associated with CVD, with 1.4 million new cases of diabetes diagnosed in the US yearly. MetS is a link to both CVD and T2D as it develops earlier than both of the other conditions, thus, targeting MetS in its early stages may help avoid the later onset of either frank CVD and T2D. However, because MetS is a cluster of conditions ...

Metabolic Syndrome is a cluster of risk factors which often includes central obesity, dyslipidemia, insulin resistance, glucose intolerance, hypertension, endothelial dysfunction, as well as a pro-inflammatory, pro-oxidant, and pro-thrombotic environment. This leads to a dramatically increased risk of developing type II diabetes mellitus and cardiovascular disease, which is the leading cause of death both in the United States and worldwide. Increasing evidence suggests that berry fruit consumption has a significant potential in the prevention and treatment of most risk factors associated with Metabolic Syndrome and its cardiovascular complications in the human population. This is likely due to the presence of polyphenols with known antioxidant and anti-inflammatory effects, such as anthocyanins and/or phenolic acids. The present review summarizes the findings of recent dietary interventions with berry fruits on human subjects with or at risk of Metabolic Syndrome. It also discusses the potential role of

The beneficial effects of Greenselect Phytosome, a proprietary lecithin formulation of a caffeine-free green tea catechin extract, were evaluated in a controlled registry study on 50 asymptomatic subjects borderline for metabolic syndrome factors and with increased plasma oxidative stress. After 24 weeks of intervention, improvement in weight, blood lipid profile, and blood pressure positioned 68% of subjects in the treatment arm out of the metabolic syndrome profile, while 80% of the subjects in the control group still remained in their initial borderline disease signature. Compared to the control (lifestyle and dietary changes alone), Greenselect Phytosome was especially effective for weight/waist changes. These results highlight the relevance of addressing multiple factors involved in the development of metabolic syndrome with a pleiotropic agent capable of improving the beneficial effects of lifestyle and dietary changes and foster the attainment of a globally improved health profile.

Current diagnostic criteria for the metabolic syndrome were designed for adults and do not consider race. Even diagnostic criteria modified for use in adolescents tend to miss some children who likely are at increased risk, especially male African Americans, DeBoer said. Black adults have higher rates of Type 2 diabetes and death due to heart disease than do whites, U.S. statistics show, but the metabolic syndrome is less likely to be diagnosed in black male youth. DeBoer and his research partner Matthew Gurka, PhD, of West Virginia University, Morgantown, studied whether the characteristics of the metabolic syndrome might vary for different racial and ethnic groups ...

Visceral adipose thickness (VAT) at abdominal level is related to the risk factors associated with cardiovascular diseases and the validation of accurate ultrasonography (US) protocols may favour the introduction of VAT assessment in clinical practice. However, predictive VAT cut-offs of risk of metabolic syndrome are not available. The aims of this study were 1) to investigate the association between (VAT) measured by US and components of metabolic syndrome (MS) and 2) to identify predictive cut-off values of risk of MS according to sex and age in a large Caucasian sample. Anthropometric measurements, blood pressure, fasting plasma glucose, HDL-cholesterol, triglycerides VAT by abdominal ultrasonography were assessed in 3431 subjects (981 males, 2450 females mean age 46,8 ± 13,4 years). VAT was defined as the distance between the anterior wall of the aorta and the posterior surface of the rectus abdominis muscle measured above the umbilicus at the xiphoumbilical line. MS was diagnosed by IDF ...

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Neck circumference (NC) is a novel simple and stable body measurement, a growing body of evidence indicates its validity to diagnose obesity and metabolic syndrome (MetS). Because the cutoff value of NC is gender and ethnic-specific; we conducted the current study to explore the performance of NC to predict general obesity, central obesity, and MetS among adult Saudis of both genders. This is a cross-sectional study which included 3063 adult Saudis (1156 males and 1907 females) with a mean age of 38.6 ± 14.1 years. Anthropometric measurements and blood pressure were assessed by a standardized methodology. Blood tests including fasting lipid panel, blood glucose, fasting blood glucose and hemoglobin A1c (HBA1c) were measured for all participants. We identified the MetS based on Adult Treatment Panel III (ATPIII definition). Data were analyzed using SPSS®19 (PASW statistics data document 19); NC was compared to relevant anthropometric measures to predict obesity and MetS using Receiver Operator

One of the proposed causes of obesity and metabolic syndrome is the excessive intake of products containing added sugars, in particular, fructose. Although the ability of excessive intake of fructose to induce metabolic syndrome is mounting, to date, no study has addressed whether a diet specifically lowering fructose but not total carbohydrates can reduce features of metabolic syndrome. A total of 131 patients were randomized to compare the short-term effects of 2 energy-restricted diets-a low-fructose diet vs a moderate natural fructose diet-on weight loss and metabolic syndrome parameters. Patients were randomized to receive 1500, 1800, or 2000 cal diets according to sex, age, and height. Because natural fructose might be differently absorbed compared with fructose from added sugars, we randomized obese subjects to either a low-fructose diet (,20 g/d) or a moderate-fructose diet with natural fruit supplements (50-70 g/d) and compared the effects of both diets on the primary outcome of weight ...

The treatment and prevention of the metabolic syndrome (MetS) is currently one of the major challenges in medicine. The impact of working conditions on metabolic risk has not been adequately studied. Our objective was to compare the prevalence of MetS and metabolic risk in two extremely different occupational groups: firefighters and office workers. A total of 143 male subjects (97 firefighters and 46 office workers) from Germany participated in the study. Anthropometric characteristics, metabolic risk parameters as well as laboratory parameters were collected. MetS was diagnosed according to criteria of the International Diabetes Federation. Sedentary occupation showed a significant tendency towards obesity. Abdominal waist circumference was significantly greater in office workers than in firefighters [5.08 CI (1.44-8.71), p = 0.007]. Concerning metabolic risk factors, abnormal HDL, triglycerides, BMI, blood pressure and waist circumference values were more frequently found in office workers ...

TY - JOUR. T1 - Adipokine Dysregulation and Insulin Resistance with Atherosclerotic Vascular Disease. T2 - Metabolic Syndrome or Independent Sequelae?. AU - Satish, Mohan. AU - Saxena, Shailendra K.. AU - Agrawal, Devendra K.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Adipokine dysregulation and insulin resistance are two hallmark sequelae attributed to the current clinical definition of metabolic syndrome (MetS) that are also linked to atherosclerotic vascular disease. Here, we critically discuss the underlying pathophysiological mechanisms and the interplay between the two sequelae. Adipokine dysregulation is involved with decreased nitric oxide, vascular inflammation, and insulin resistance in itself to promote atherosclerosis. Insulin resistance is involved with endothelial dysfunction by direct and indirect mechanisms that also promote vascular inflammation and atherosclerosis. These mechanisms are discussed in atherosclerosis irrespective of MetS, and to evaluate the possibility of synergism in ...

The present meta-analysis, performed in 50 studies, with an overall incorporated population of approximately one-half million subjects, revealed the beneficial effect of the MD, with regard to not only the MS but also its individual components, namely waist circumference, HDL cholesterol levels, triglyceride levels, blood pressure levels, and glucose metabolism. The significant heterogeneity observed mainly on the effect of the MD on MS components was partially attributed to the location of studies (i.e., Mediterranean or not), the intervention duration, the number of the participants, and the quality of the studies. To the best of our knowledge, this is the first work that has systematically assessed, through meta-analysis, the role of the MD on MS and its components.. The MD is one of the most known and well-studied dietary patterns, which has been shown to be associated with human health, especially decreased mortality from all causes, lower risk for cardiovascular disease, and cancer (8); it ...

TY - JOUR. T1 - Association between endothelial nitric oxide synthase polymorphisms and risk of metabolic syndrome. AU - Liu, Chiu Shong. AU - Huang, Ru Jiun. AU - Sung, Fung Chang. AU - Lin, Cheng Chieh. AU - Yeh, Chih Ching. PY - 2013. Y1 - 2013. N2 - Background: Previous studies inferring that the NOS3 gene was associated with the pathogenesis of metabolic syndrome (MetS) had inconsistent findings. We investigated the role of three NOS3 polymorphisms (T-786C, intron 4b/a, and G894T) in the risk of MetS using a hospital-based case-control study. Methods: We recruited 339 MetS cases and 783 non-MetS controls at a central Taiwanese hospital. Information on sociodemographic and lifestyle factors was obtained using a self-administered questionnaire. Genotypes of NOS3 polymorphisms were compared between cases and controls. Effects of interactions between gene polymorphisms and smoking and between gene polymorphisms and drinking on the risk of MetS were also determined. Results: The T-786C TC+CC ...

Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.