BACKGROUND: Individual participant data (IPD) meta-analyses that obtain raw data from studies rather than summary data typically adopt a two-stage approach to analysis whereby IPD within trials generate summary measures, which are combined using standard meta-analytical methods. Recently, a range of one-stage approaches which combine all individual participant data in a single meta-analysis have been suggested as providing a more powerful and flexible approach. However, they are more complex to implement and require statistical support. This study uses a dataset to compare two-stage and one-stage models of varying complexity, to ascertain whether results obtained from the approaches differ in a clinically meaningful way. METHODS AND FINDINGS: We included data from 24 randomised controlled trials, evaluating antiplatelet agents, for the prevention of pre-eclampsia in pregnancy. We performed two-stage and one-stage IPD meta-analyses to estimate overall treatment effect and to explore potential
Medical education Comparing medical knowledge of osteopathic medical trainees in DO and MD programs: A random effect meta-analysis LINJUN SHEN, PhD; THOMAS CAVALIER!, DO; MICHAEL CLEARFIELD, DO; JOSEPH SMOLEY, PhD The authors used random effect meta-analysis to synthesize eight mean score differences of the Part BI/Level 3 examinations of the National Board of Osteo-pathic Medical Examiners (NBOME) between osteopathic medical trainees in DO residency programs and osteopathic medical trainees in MD programs. The anal-ysis involved 6001 trainees and all Part III or Level 3 examinations since 1992. The average mean score difference was not significantly different from zero; however, the estimates of true effect sizes of each examination varied substantially. The findings indicate that, overall, medical knowledge of osteopathic trainees in MD and DO residency programs is compatible at the time they took the exam-inations. However, a large variation of effect size suggests the need for further ...
TY - JOUR. T1 - The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. T2 - Design and multicenter pilot study. AU - Meta VCI Map consortium. AU - Calgary Normative Study group. AU - Framingham Heart Study group. AU - The Dutch Parelsnoer Institute - Neurodegenerative diseases group. AU - TABASCO group. AU - Weaver, Nick A.. AU - Zhao, Lei. AU - Biesbroek, J. Matthijs. AU - Kuijf, Hugo J.. AU - Aben, Hugo P.. AU - Bae, Hee Joon. AU - Caballero, Miguel Á.A.. AU - Chappell, Francesca M.. AU - Chen, Christopher P.L.H.. AU - Dichgans, Martin. AU - Duering, Marco. AU - Georgakis, Marios K.. AU - van der Giessen, Ruben S.. AU - Gyanwali, Bibek. AU - Hamilton, Olivia K.L.. AU - Hilal, Saima. AU - vom Hofe, Elise M.. AU - de Kort, Paul L.M.. AU - Koudstaal, Peter J.. AU - Lam, Bonnie Y.K.. AU - Lim, Jae Sung. AU - Makin, Stephen D.J.. AU - Mok, Vincent C.T.. AU - Shi, Lin. AU - Valdés Hernández, Maria C.. AU - ...
TY - JOUR. T1 - Repeat prenatal corticosteroid prior to preterm birth. T2 - A systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: Assessing the effects using the best level of evidence) - study protocol. AU - Crowther, Caroline A.. AU - Aghajafari, Fariba. AU - Askie, Lisa M.. AU - Asztalos, Elizabeth V.. AU - Brocklehurst, Peter. AU - Bubner, Tanya K.. AU - Doyle, Lex W.. AU - Dutta, Sourabh. AU - Garite, Thomas J.. AU - Guinn, Debra A.. AU - Hallman, Mikko. AU - Hannah, Mary E.. AU - Hardy, Pollyanna. AU - Maurel, Kimberly. AU - Mazumder, Premasish. AU - McEvoy, Cynthia (Cindy). AU - Middleton, Philippa F.. AU - Murphy, Kellie E.. AU - Peltoniemi, Outi M.. AU - Peters, Dawn. AU - Sullivan, Lisa. AU - Thom, Elizabeth A.. AU - Voysey, Merryn. AU - Wapner, Ronald J.. AU - Yelland, Lisa. AU - Zhang, Sasha. PY - 2012/2/12. Y1 - 2012/2/12. N2 - Background: The aim of this individual participant ...
PubMed journal article Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trial were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
The objective of the present study was to review previous investigations on the association of haplotypes in the G-protein β3 subunit (GNB3) gene with representative cardiovascular risk factors/phenotypes: hypertension, overweight, and variation in the systolic and diastolic blood pressures (SBP and DBP, respectively) and as well as body mass index (BMI). A comprehensive literature search was undertaken in Pubmed, Web of Science, EMBASE, Biological Abstracts, LILACS and Google Scholar to identify potentially relevant articles published up to April 2011. Six genetic association studies encompassing 16,068 participants were identified. Individual participant data were obtained for all studies. The three most investigated GNB3 polymorphisms (G-350A, C825T and C1429T) were considered. Expectation-maximization and generalized linear models were employed to estimate haplotypic effects from data with uncertain phase while adjusting for covariates. Study-specific results were combined through a ...
BACKGROUND: Calls have been made for increased access to individual participant data (IPD) from clinical trials, to ensure that complete evidence is available. However, despite the obvious benefits, progress towards this is frustratingly slow. In the meantime, many systematic reviews have already collected IPD from clinical trials. We propose that a central repository for these IPD should be established to ensure that these datasets are safeguarded and made available for use by others, building on the strengths and advantages of the collaborative groups that have been brought together in developing the datasets. OBJECTIVE: Evaluate the level of support, and identify major issues, for establishing a central repository of IPD. DESIGN: On-line survey with email reminders. PARTICIPANTS: 71 reviewers affiliated with the Cochrane Collaborations IPD Meta-analysis Methods Group were invited to participate. RESULTS: 30 (42%) invitees responded: 28 (93%) had been involved in an IPD review and 24 (80%) had been
Meta-analysis has a long history within the medical sciences and epidemiology [1,2,3]. The main goal of a meta-analysis is to improve the precision of a specific effect size of a treatment or an exposure on a clinical or disease outcome by pooling or combining multiple studies. It is frequently conducted within a systematic review of the scientific literature to guarantee that studies with appropriate information are not ignored or overlooked and to make sure that the pooled estimate represents an unbiased and precise estimate of the true effect size. Moreover, the pooled effect estimate is evaluated in the context of study heterogeneity. In case substantial heterogeneity in the effect sizes across studies is present, the pooled estimate is considered less reliable or even questionable. Thus not only the pooled estimate must be unbiased, also the estimate of the measure of heterogeneity should be correct. Within the area of medical statistics, meta-analysis has evolved into an important and rich ...
Network meta-analyses are increasingly used to determine the best available healthcare interventions among all existing treatments for one specific disease. We showed that the conduct, reporting and interpretation of network meta-analyses was questionable. Particularly, the search strategy, assessment of risk of bias and publication bias were inappropriate in most publications. Furthermore, we showed that treatment rankings usually reported with no credibility interval have a substantial degree of imprecision, with a 50% or greater probability that the best-ranked treatment was actually not the best in 28% of networks. We also investigated whether conventional meta-analyses meet clinicians and patients needs. Our results revealed a substantial waste of research, with more than 40% of treatments, treatment comparisons, and trials not covered by existing systematic reviews. We developed a new paradigm, the "live cumulative network meta-analysis", a single network meta-analysis covering all ...
An Individual Patient Data (IPD) meta-analysis is often considered the gold-standard for synthesising survival data from clinical trials. An IPD meta-analysis can be achieved by either a two-stage or a one-stage approach, depending on whether the trials are analysed separately or simultaneously. A range of one-stage hierarchical Cox models have been previously proposed, but these are known to be computationally intensive and are not currently available in all standard statistical software. We describe an alternative approach using Poisson based Generalised Linear Models (GLMs). We illustrate, through application and simulation, the Poisson approach both classically and in a Bayesian framework, in two-stage and one-stage approaches. We outline the benefits of our one-stage approach through extension to modelling treatment-covariate interactions and non-proportional hazards. Ten trials of hypertension treatment, with all-cause death the outcome of interest, are used to apply and assess the approach. We
An application of multivariate meta-analysis for pooling estimates of non-linear associations from multiple studies. The code included is applicable beyond the specific setting of time series analysis of temperature-health relationships. The example illustrate the analysis in the article: Gasparrini A, Armstrong B, Kenward MG. Multivariate meta-analysis for non-linear and other multi-parameter associations. Statistics in Medicine. 2012;31(29):3821-39. The original example included in the article was based on data from the National Mortality, Morbidity, and Air Pollution Study (NMMAPS), which at the time of the publication was available through the R package NMMAPSlite. Unfortunately, the data are not available any more and the package NMMAPSlite has been archived. In order to provide a working example, the analysis has been replaced with a similar analysis on a publicly available dataset. The material covers: [1] regEngWales.csv stores the dataset used to perform an illustrative example, ...
Confidence intervals for the between-study variance in random-effects meta-analysis using generalised heterogeneity statistics: should we use unequal tails. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
We read with deep interest the article by Wang et al1 aimed to compare the efficacy of 20 non-steroidal anti-inflammatory drugs (NSAIDs) in the short-term treatment of ankylosing spondylitis (AS). This Bayesian network meta-analysis indicated that etoricoxib was more effective in reducing pain in AS than some other NSAIDs. The result was very useful in the decision-making process, especially for pain relief in treating patients with AS. However, there are some worthwhile issues that need to be explored.. First, it is commonly agreed that meta-analysis, including network meta-analysis, should assess heterogeneity, which may be defined as the presence of variation in true effect sizes underlying the different studies. Unfortunately, however, heterogeneity was not assessed in this network meta-analysis. Between-study heterogeneity indicates the presence of effect modifiers, and variability in relative treatment effects has a bad impact on the external validity of trial evidence, and limits the ...
BACKGROUND: The last 30 years have seen an exponential increase in metaanalyses. By combining multiple studies, metaanalysis can provide an overview of the totality of evidence on a particular question and the statistical power needed to reduce random error and produce precise estimates of even modest effect sizes. This capability is of particular value when many small studies address similar questions [such as in the investigation of novel cardiovascular disease (CVD) biomarkers]. To provide reliable evidence, however, metaanalyses must be undertaken robustly. CONTENT: In this review, we describe the major issues to consider when designing and conducting metaanalyses, including the design of constituent studies, selection criteria, assessment of exposures and disease outcomes, and control of bias and confounding. Some of the potential challenges and pitfalls associated with metaanalysis are examined, and their consequences are considered. We use 2 examples of novel biomarkers for CVD-homocysteine and
Meta-analysis is the use of statistical methods to combine evidence across studies for the purposes of drawing general conclusions. The results of each study are summarized by a quantitative index called an "effect size," and then the effect sizes from each study are combined across studies to obtain an overall summary effect. Meta-analysis differs from secondary analysis because the latter involves analysis of the raw data from each study, but meta-analysis typically uses only summaries of the raw data from each study (the effect sizes), not the raw data itself. Meta-analyses may have any of several primary objectives. In many cases, meta-analyses are carried out to obtain a summary of average effects. In other cases, they may be carried out to study differential effects of a treatment on different subject populations, different treatment contexts, different variations of a treatment, or different outcome measures. It is also common for meta-analysts to use their results to identify areas of ...
The purpose of the Bulletin of Economics and Meta-Analysis (BEMA) is to provide a forum for recent meta-analyses in economics, to publish fresh research quickly, and thereby to improve the quality of meta-analytic research before it is submitted to traditional scholarly journals. We seek to publish, electronically, short notes and longer abstracts that briefly sketch recent research about meta-analysis or that employs meta-analysis. It is assumed that all notes submitted will contain links to longer working papers. Authors wishing to have their notes considered for publication in BEMA should submit them for review to: [email protected] ...
Fast and easy meta-analysis software. Research synthesis, systematic review for finding effect size, creating forest plots, and much more. Free trial.
Background and aims: Our study aims to evaluate the efficacy and safety of long-term treatment of statins for coronary heart disease (CHD). Methods: Efficacy outcomes included changes in blood lipids, risk of CHD mortality and all-cause mortality. Safety outcomes were evaluated by the risk of adverse events (AE). Bayesian network meta-analysis was used to compare the direct and indirect effects between different statins. Results: The systematic review showed that levels of blood lipids decreased during statin treatment. High dose of atorvastatin was the most obvious treatment for the reduction of blood lipids. Network meta-analysis showed that statins were significantly more effective than the control in reducing the risk of CHD mortality (Odds Ratio (OR) 0.69, 95% CI 0.61-0.77) and all-cause mortality (OR 0.84, 95% CI 0.80-0.87). In terms of reducing the risk of CHD morality, fluvastatin (77.3%), atorvastatin (72.3%) and lovastatin (68.4%) had higher cumulative probability than other statins, ...
Compute variance-covariance matrix for multivariate meta-analysis. Effect sizes include correlation (r), mean difference (MD), standardized mean difference (SMD), log odds ratio (logOR), log risk ratio (logRR), and risk difference (RD).. ...
Evidence-based health-care decision making requires comparisons of all relevant competing interventions. In the absence of randomized, controlled trials involving a direct comparison of all treatments of interest, indirect treatment comparisons and network meta-analysis provide useful evidence for j …
Health,A recent meta-analysis of five major breast cancer trials has confirme...At the ESMO Conference Lugano Issa Dahabreh from the University...All the trials compared disease-free survival overall survival and...Up to a quarter of all breast cancers express large amounts of t...The results showed that combining trastuzumab with chemotherapy ...,Combination,of,Tratuzumab,and,Chemotherapy,Yields,Better,Results,for,Breast,Cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Here are three studies (for all abstracts & links see below) highlighting the increasingly encouraging results being reported for internet-delivered psychological interventions. Vant Hof, Cuijpers et al report on ... a systematic review of meta-analyses on the efficacy of self-help interventions, including internet-guided therapy, for depression and anxiety disorders. They conclude that the 13 meta-analyses indicate self-help methods are effective in a range of different disorders, including depression and anxiety disorders. Most meta-analyses found relatively large effect sizes for self-help treatments, independent of the type of self-help, and comparable to effect sizes for face-to-face treatments (see below for abstracts and links to the six research papers mentioned). Riper, Kramer et al describe how an experimental internet-delivered self-help alcohol reduction intervention transferred well to being made more generally available. The authors conclude that .... ...
The number of studies on the association between clock genes polymorphisms and cancer susceptibility has increased over the last years but the results are often conflicting and no comprehensive overview and quantitative summary of the evidence in this field is available. RESULTS: Literature search identified 27 eligible studies comprising 96756 subjects (cases: 38231) and investigating 687 polymorphisms involving 14 clock genes. Overall, 1025 primary and subgroup meta-analyses on 366 gene variants were performed. Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkins lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 ...
A study appeared this week sure to drive members of the low-fat and vegan tribes sprinting for their Protexid.. Ron Krauss and his group published a paper in the Articles in Press section of the American Journal of Clinical Nutrition (AJCN) stating there is no evidence that saturated fat intake increases the risk for heart disease. The paper, titled Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease, is not a study per se, but is a meta-analysis, a compilation of numerous studies looking at the relationship between saturated fat intake and the risk for developing heart disease.. As Ive discussed before on these pages, meta-analyses are not my favorite types of studies. Ive attacked them when theyve been used to prove the low-fat diets are better, so I cant very well embrace meta-analyses when they present a conclusion I agree with. And I really cant embrace meta-analyses when they are compilations of observational studies, ...
There is an emerging body of literature relating to the effectiveness of frequent aerobic exercise as a prophylactic for age-associated dysfunction of large arteries, yet systematic evaluation and precise estimate of this effect is unknown. We conducted a systematic review and meta-analysis of controlled studies examining flow mediated dilatation (FMD) of athletic older persons and otherwise healthy sedentary counterparts to (i) compare FMD as a determinant of endothelial function between athletes and sedentary individuals and, (ii) summarize the effect of exercise training on FMD in studies of sedentary aging persons. Studies were identified from systematic search of major electronic databases from inception to January 2018. Study quality was assessed before conducting a random effects meta-analysis to calculate a pooled ES (mean difference) with 95% CIs. Thirteen studies [4 interventional (n = 125); 10 cross-sectional [including one study from the interventional analysis; (n = 485)] with age ...
Findings Twenty NMAs were eligible for inclusion. The number of randomised controlled trials per NMA ranged from 11 to 234, and included between 801 to more than 26 000 participants. Overall, antidepressants were found to be efficacious and tolerable agents for several disorders based on rankings (45%) or statistical significance (55%). The majority of NMAs in this review adhered to guidelines by including a network diagram (70%), assessing consistency (75%), making use of a random effects model (75%), providing information on the model used to fit the data (75%) and adjusting for covariates (75%). ...
Results from the present study add to the growing body of studies showing that iSMIs can be an accessible and effective way of reducing work-related stress. In line with our expectations, we found that the guided iSMI effectively reduces symptoms of perceived stress in a sample of distressed managers. Analyses also indicate effects on other mental health and work-related outcomes. Long-term effects were seen on several of the mental health-related outcomes (perceived stress, insomnia and cognitive weariness). However, effects on the work-related outcomes were not sustained at the 6 months follow-up.. The effects found in the present study were larger compared with those found in our previous iSMIs trials (d≈0.60),23 25 however within CI of guided interventions (Cohens d=0.64, 95% CI 0.50 to 0.79) presented in a recently published meta-analyses on iSMI.24 Compared with regular face-to-face CBT-based SMIs, d=0.68 to 1.16,17 our effects are lower on stress-related measures (perceived stress, ...
Meta-analysis is a formal quantitative method for pooling scientific data reported from multiple studies, therefore allowing for an evaluation of the treatment or exposure effect on a specific health outcome. In a meta-analysis, researchers assess heterogeneity across studies, examine subgroups of studies to determine if selected subsets of the research data provide similar or different results, and calculate summary relative risk estimates. A meta-analysis provides a statistically precise summary risk estimate, as well as a better understanding of the consistency of reported findings (or lack of) in the research literature. A meta-analysis is distinct from a qualitative or narrative review in that a meta-analysis involves a systematic review of the literature, relevant data extraction, and quantitative analyses of data across multiple studies. A pooled analysis is similar to a traditional meta-analysis, except that participant-level data from multiple studies are combined and analyzed as a ...
Meta-analysis can be used to examine differences in treatment effects across trials; however, the fact that randomised trials are included in meta-analyses does not mean that comparisons between trials are also randomised comparisons. Meta-analytic subgroup analyses, like subgroup analyses within trials, are prone to bias and need to be interpreted with caution. A more reliable way of assessing differences in treatment effects is to relate outcome to some underlying patient characteristic on a continuous, or ordered, scale. The underlying level of risk is a key variable which is often related to a given treatment effect, with patients at higher risk receiving more benefit then low risk patients. Individual patient data, rather than published summary statistics, are often required for meaningful subgroup analyses. ...
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Reply to High-Quality Meta-Analyses Are Required for Development of Evidence in Medicine. Hagan, Holly; Jarlais, Don C. Des; Pouget, Enrique // Journal of Infectious Diseases;5/1/2012, Vol. 205 Issue 9, p1473 A response by Holly Hagan, Don C. Des Jarlais and Enrique Pouget to a letter to the editor about his article "A systematic review and meta-analysis of interventions to prevent hepatitis C virus infection in people who inject drugs, in a 2011 issue of the journal, which discusses the treatment... ...
AlzRisk is a collection of findings from published epidemiologic reports that evaluate environmental and other non-genetic risk factors for Alzheimers disease. For each risk factor included in the database, summaries of key characteristics of the studies, as well as interpretive remarks, are included. Random-effects meta-analyses are conducted when comparable data are available from at least four independent samples.. SEARCH THE ALZRISK DATABASE. ...
According to the report of the International Association for the Study of Obesity (34), the PA level that was defined as the ratio of average daily metabolic rate to resting metabolic rate ranged from 1.5-1.6 for men and 1.4-1.5 for women in sedentary groups. Additionally, in general, the minimum PA volume for avoiding a sedentary lifestyle was indicated to be 30 min of daily activity at 3 METs of intensity (34). In the studies in the current meta-analysis, the mean PA dose in the lowest group was at most 30 MET-h/day in terms of EE (i.e., 1.25 [= 30/24] in the PA level unit) or 30 min/day of LTPA. Therefore, these PA levels can be considered to represent inactivity. The results of the current meta-analysis can be interpreted to indicate that a high PA in patients with diabetes was associated with a 40 and 29% lower risk of ACM and CVD, respectively, in comparison with inactivity, although definitions of high PA varied among studies. In comparison with other lifestyle factors, these values ...
This analysis of cohorts from the Asia Pacific region clearly indicates a positive continuous association between usual blood glucose and CVD risk. This association extends down to about 4.9 mmol/l, well below the usual fasting glucose cutoff levels for diagnosis of diabetes and impaired glucose tolerance. The positive association was maintained when individuals with diabetes at baseline were excluded and with adjustment for potential confounders. The associations were very similar for males and females and across age subgroups. There was no strong evidence of regional differences, but small numbers limited subgroup analysis. The overall associations for usual nonfasting glucose were weaker than those for usual fasting glucose; however, nonfasting measures are less robust because they are affected by the postprandial state.. This study has several advantages over previous studies, such as the substantial size of the database, the availability of individual participant data across a range of ...
Chung, Y., Rabe-Hesketh, S., & Choi, I. - H.. (2013). Avoiding zero between-study variance estimates in random-effects meta-analysis. Statistics in Medicine, 33(23 ...
Our study has several strengths. Firstly, network meta-analysis allowed comparison of all available strategies in a single analysis, giving a combined total of 59 622 patient years of treatment, rather than separate and disconnected meta-analyses for individual pairs of treatments. By conducting a network meta-analysis we were able to provide a formal rank order for treatment strategies by their capacity to reduce exacerbations, while capturing the imprecision of such rankings.. Secondly, we carefully developed the inclusion criteria for trials. As exacerbations are relatively infrequent outcomes, we restricted our study to reports with treatment durations of at least 24 weeks (close to six months) to reflect the effects of long term treatment in a variable disease. In several other meta-analyses with exacerbations as an outcome variable, the bulk of the evidence has originated from studies with durations of intervention between three and six months, a relatively short period as asthma treatment ...
Alternatively, the frequentist multivariate solutions contain approximations and assumptions that are not stated explicitly or confirmed when the strategies are applied (see discussion on meta-analysis designs over). As an example, the mvmeta bundle for Stata allows community meta-analysis inside of a frequentist framework.[63] Nevertheless, if there isnt a prevalent comparator while in the network, then this should be managed by augmenting the dataset with fictional arms with higher variance, which isnt pretty objective and involves a call as to what constitutes a adequately large variance ...
Meta-analysis is a statistical approach that combines the results of multiple scientific studies. Although many genetic studies have been conducted to discovery genetic risk factors for T1D, combining the results from these separated studies by using meta-analysis could lead to a higher statistical power and more robust point estimate. In this study, meta-analysis was performed on seven T1D case/control bio-sets extracted from four recent studies. T1D target genes from meta-analysis were sorted by gene score, which is based on the statistical significance and consistency of the gene across the queried bio-sets. Meta-analysis results suggested six top risk genes for T1D (Score ≥ 85), and four of them are novel according to a recently updated database T1D_GD. Further analyses were conducted to study the possible correlation between T1D and these six genes, with more efforts focused on the four novel ones.. Analysis using T1D_GD showed that the two known T1D target genes, HLA-DQB1 and OAS1, are ...
Zhi-Chao Hu, Qian Tang, Chang-Min Sang, Li Tang, Xiaobin Li, Gang Zheng, Zhen-Hua Feng, Jiang-Wei Xuan, Zhi-Hao Shen, Li-Yan Shen, Wen-Fei Ni, Ai-Min Wu ...
Fast and easy statistical analysis software. Research synthesis, systematic review for finding effect size, creating forest plots, and more. Free trial.
Sometimes we ask the wrong question of simple drugs. Like when we add clonidine to a peripheral block. A post from Andrew Weatherall touching on a recent meta-analysis on this topic. Most places I work, people agree that volatile agents get people to sleep. They pretty much look on things ending in -ronium or -curium as substances…
Cahill · 12/31/02 at 2:44 PM ET Ricky:. Im neither Larry nor Lawrence. Rather, its Shawn. Im not nearly as well published as Larry Cahill of Cahill & McGaugh fame (among others). In follow-up to discussion of the Davidson & Parker meta-analysis, your post of 12/28 stated This meta-analysis is controversial for a number of reasons, this opinion being one of them. If you look at the actual studies pertaining to the possible role of eye movements, you would almost certainly come to a different conclusion than the authors of this meta-analysis. I then pointed out, and you agreed 12/29 post, that one cannot criticize a study or meta-analysis on the basis of its conclusions. Indeed, you state I agree with you that studies should be judged according to their design/procedures, not their results. Like any other study, judgment calls are inherent to meta-analyses. How to select studies for inclusion, whether/how to weight them, how to interpret/categorize their findings. But then, you dont ...
Cancer is associated with severe disease in COVID-19 patients: a systematic review and meta-analysis Richard Ofori-Asenso1,2, Oyepeju Ogundipe3, Akosua Adom Ag
Resources and networking for those who conduct or interpret meta-analyses related to any phenomenon that is gauged in multiple studies.
Resources and networking for those who conduct or interpret meta-analyses related to any phenomenon that is gauged in multiple studies.
The meta-analysis of 22 randomized trials included more than 9,000 patients with recent follow-up of previously published studies. Added that these results are
Take a look at JVB's most highly read meta-analysis papers in 2017 (published 2000 - 2017): Affective, normative, and continuance...
Soesma A Jankipersadsing, Fatemeh Hadizadeh, Marc Jan Bonder, Ettje F Tigchelaar, Patrick Deelen, Jingyuan Fu, Anna Andreasson, Lars Agreus, Susanna Walter, Cisca Wijmenga, Pirro Hysi, Mauro DAmato, Alexandra Zhernakova ...
Pooling of data from 14,874 women in an individual participant data meta-analysis by Nicola Low and colleagues reveals that some intravaginal practices increase the risk of HIV acquisition.
Dietary Reference Values (DRVs) for vitamin D have a key role in the prevention of vitamin D deficiency. However, despite adopting similar risk assessment protocols, estimates from authoritative agencies over the last 6 years have been diverse. This may have arisen from diverse approaches to data analysis. Modelling strategies for pooling of individual subject data from cognate vitamin D randomized controlled trials (RCTs) are likely to provide the most appropriate DRV estimates. Thus, the objective of the present work was to undertake the first-ever individual participant data (IPD)-level meta-regression, which is increasingly recognized as best practice, from seven winter-based RCTs (with 882 participants ranging in age from 4 to 90 years) of the vitamin D intake-serum 25-hydroxyvitamin D (25(OH)D) dose-response. Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of 25(OH)D concentrations >25, 30, and 50 nmol/L across the population are 10, 13, and 26 µg/day, respectively.
article{2a540d9f-73ba-41d7-8442-fe16f20afb72, abstract = {,p,Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues. The meta-analysis resulted in a list of 536 suggestive genome wide significant SNPs in or near 69 genes. Further interrogation with Pathway Analysis placed gait speed as a polygenic complex trait in five major networks. Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in addition to the ...
Downloadable! Despite the vast literature dealing with the impact of the subsidies on world cotton prices, there is no consensus regarding the quantification of these effects. The aim of this paper is to contribute to this literature through the implementation of a meta-regression analysis. This methodology allows us to: (i) identify the main sources of heterogeneity between the primary studies, (ii) give some tracks to improve the modeling, (iii) provide a reliable quantification of the removal of subsidies on world cotton prices. Relying on the estimation of various models to derive robust results, our findings show that a withdrawal of US subsidies would increase the world cotton price by around 10%.
Granulocyte colony stimulating factor (G-CSF) may enhance recovery from stroke through neuroprotective mechanisms if administered early, or neurorepair if given later. Several small trials suggest administration is safe but effects on efficacy are unclear. We searched for randomised controlled trials (RCT) assessing G-CSF in patients with hyperacute, acute, subacute or chronic stroke, and asked Investigators to share individual patient data on baseline characteristics, stroke severity and type, end-of trial modified Rankin Scale (mRS), Barthel Index, haematological parameters, serious adverse events and death. Multiple variable analyses were adjusted for age, sex, baseline severity and time-to-treatment. Individual patient data were obtained for 6 of 10 RCTs comprising 196 stroke patients (116 G-CSF, 80 placebo), mean age 67.1 (SD 12.9), 92% ischaemic, median NIHSS 10 (IQR 5-15), randomised 11 days (interquartile range IQR 4-238) post ictus; data from three commercial trials were not shared. ...
Objectives: To assess the accuracy in diagnosing heart failure of clinical features and potential primary care investigations, and to perform a decision analysis to test the impact of plausible diagnostic strategies on costs and diagnostic yield in the UK health-care setting. Data sources: MEDLINE and CINAHL were searched from inception to 7 July 2006. Grey literature databases and conference proceedings were searched and authors of relevant studies contacted for data that could not be extracted from the published papers. Review methods: A systematic review of the clinical evidence was carried out according to standard methods. Individual patient data (IPD) analysis was performed on nine studies, and a logistic regression model to predict heart failure was developed on one of the data sets and validated on the other data sets. Cost-effectiveness modelling was based on a decision tree that compared different plausible investigation strategies. Results: Dyspnoea was the only symptom or sign with high
Brindle, R. C., Ginty, A. T., Phillips, A. C. and Carroll, D. (2014), A tale of two mechanisms: A meta-analytic approach toward understanding the autonomic basis of cardiovascular reactivity to acute psychological stress. Psychophysiology, 51: 964-976. doi: 10.1111/psyp.12248 ...
See related article, pp 642-653. In this issue of the journal, Verdecchia et al1 report an important analysis of the accumulation of evidence comparing more versus less intensive blood pressure (BP)-lowering strategies. Their key message is critical for guidelines and practice internationally: with the addition of SPRINT (Systolic Blood Pressure Intervention Trial),2 this set of trials now provides compelling evidence that more intensive BP-lowering reduces stroke and myocardial infarction (MI), and significant reductions are now also seen in cardiovascular death and heart failure. The authors have also assessed sequential monitoring boundaries for each outcome, making the analogy of a hypothetical Data and Safety Monitoring Board (DSMB) assessing the accumulation of evidence in the field.. Before examining the implications, it is worth reviewing the techniques and aims of the cumulative meta-analysis and trial sequential analysis methods used by Verdecchia et al.1 Cumulative meta-analysis ...
The current study used a convenience sample of 95 SRs included across seven overview topics to provide empirical evidence on issues surrounding quality assessments of SRs in overviews. This study found that AMSTAR assessments and inter-rater reliability were higher for Cochrane compared to non-Cochrane SRs; these results were consistent within each overview topic and for many of the individual questions of the AMSTAR tool. Minor challenges were encountered when assessing quality of SRs in the context of overviews, but decision rules were developed and recommendations for overview authors were provided. Results also suggested that inter-rater reliability of Cochrane and non-Cochrane SRs may be lower for SRs with moderate AMSTAR assessments and higher for SRs that were assessed as strong; inter-rater reliability may also be higher for non-Cochrane SRs assessed as weak. Consistent with a previous study [33], we found that the conclusions, but not the results, of Cochrane and non-Cochrane SRs ...
TY - JOUR. T1 - Meta-analysis of survey data. T2 - Application to health services research. AU - Rao, Sowmya R.. AU - Graubard, Barry I.. AU - Schmid, Christopher H.. AU - Morton, Sally C.. AU - Louis, Thomas A.. AU - Zaslavsky, Alan M.. AU - Finkelstein, Dianne M.. PY - 2008/6/1. Y1 - 2008/6/1. N2 - Traditionally, meta-analysis methods have been developed and used to combine data from several independent clinical trials as well as observational studies, but have not been as widely used in survey research. This paper describes the steps in conducting such a meta-analysis of surveys, to obtain a single summary estimate from a combination of individual-level and summary data. The methods are applied in the context of a project aimed at obtaining an estimate of the prevalence of use of electronic health records.. AB - Traditionally, meta-analysis methods have been developed and used to combine data from several independent clinical trials as well as observational studies, but have not been as ...
OBJECTIVES: To survey the frequency of use of indirect comparisons in systematic reviews and evaluate the methods used in their analysis and interpretation. Also to identify alternative statistical approaches for the analysis of indirect comparisons, to assess the properties of different statistical methods used for performing indirect comparisons and to compare direct and indirect estimates of the same effects within reviews. DATA SOURCES: Electronic databases. REVIEW METHODS: The Database of Abstracts of Reviews of Effects (DARE) was searched for systematic reviews involving meta-analysis of randomised controlled trials (RCTs) that reported both direct and indirect comparisons, or indirect comparisons alone. A systematic review of MEDLINE and other databases was carried out to identify published methods for analysing indirect comparisons. Study designs were created using data from the International Stroke Trial. Random samples of patients receiving aspirin, heparin or placebo in 16 centres were used
Background Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; ,2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population. Methods and findings We evaluated the interaction between maternal malaria infection and maternal anthropometric status on the risk of LBW using pooled data from 14,633 pregnancies from 13 studies (6 cohort studies and 7 randomized controlled trials) conducted in Africa and the Western Pacific from 1996-2015. Studies were identified by the Maternal Malaria and Malnutrition (M3) initiative using a convenience sampling approach and were eligible for pooling given adequate ethical approval and availability of essential variables. Study-specific adjusted effect estimates were calculated using inverse probability of treatment-weighted linear and log-binomial regression models and pooled using a random-effects model. The adjusted risk ...
PART A: META-ANALYSIS METHODOLOGY: THE BASICS Introduction: Meta-analysis: Its Development and Uses Defining Outcome Measures used for Combining via Meta-analysis Random Effects Models for Combining Study Estimates Exploring Between Study Heterogeneity Publication Bias Study Quality Sensitivity Analysis Reporting the Results of a Meta-analysis Fixed Effects Methods for Combining Study Estimates PART B: ADVANCED AND SPECIALIZED META-ANALYSIS TOPICS Bayesian Methods in Meta-analysis Meta Regression Meta-analysis of Different Types of Data Incorporating Study Quality into a Meta-analysis Meta-analysis of Multiple and Correlated Outcome Measures Meta-analysis of Epidemiological and other Observational Studies Generalised Synthesis of Evidence ...
Dear Editor. Having recently published a meta-analysis on the same clinical question,[1] it was with great interest that we read Michael et al.s systematic review of short vs. standard duration antibiotics for urinary tract infections in children.[2] Given the publication (in close succession) of two meta-analyses on the same question with (on the surface) strikingly different results, we thought a comment was in order. First, we applaud the authors on their methodologically sound review. The literature search was explicitly described and exhaustive. In fact, the authors identified a few studies that we had missed.[3-6] The study outcomes for meta-analysis (frequency of positive urine cultures at 0-7 days after treatment and at 10 days to 15 months after treatment, and development of resistant organisms and recurrent UTI) were relevant and clearly defined. The authors provided appropriate and important meta-analysis measures including summary relative risks and a quasi-NNT calculation with ...
T]his is a comprehensive and up-to-date compendium of all relevant aspects for meta-analysis conduction in ecology, evolution, and related topics. Scientists from these areas who already have some knowledge on meta-analysis will find valuable guidance."-Daniela Vetter, Quarterly Review of Biology. "A superb guide to the conduct and interpretation of meta-analysis, from an exceptional team of international experts. This comprehensive manual covers essential concepts, steps, and standards for rigorous research synthesis in ecology and evolutionary biology. Its clear prose, helpful illustrations, and worked examples will be useful for beginners and experts alike. Highly recommended for use as a textbook or for self-study."-Julia Littell, Bryn Mawr College, coauthor of Systematic Reviews and Meta-Analysis. "This is a well-written and valuable book, one that is unique within biology. The use of meta-analysis in ecology and evolution has reached the point where there is a need for a comprehensive, ...
Accurate representation of ecosystem processes in land models is crucial for reducing predictive uncertainty in energy and greenhouse gas feedbacks with the atmosphere. Here we describe an observational and modeling meta-analysis approach to benchmark land models, and apply the method to the land model CLM4.5 with two versions of belowground biogeochemistry. We focused our analysis on the above and belowground high-latitude ecosystem responses to warming and nitrogen addition, and identified mechanisms absent, or poorly parameterized in CLM4.5. While the two model versions predicted similar trajectories for soil carbon stocks following both types of perturbation, other variables (e.g., belowground respiration) differed from the observations in both magnitude and direction, indicating the underlying mechanisms are inadequate for representing high-latitude ecosystems. The observational synthesis attribute these differences to missing representations of microbial dynamics, characterization of above ...
TY - JOUR. T1 - Correction to. T2 - Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients (Intensive Care Medicine, (2018), 44, 6, (847-856), 10.1007/s00134-018-5222-9). AU - Léopold, Valentine. AU - Gayat, Etienne. AU - Pirracchio, Romain. AU - Spinar, Jindrich. AU - Parenica, Jiri. AU - Tarvasmäki, Tuukka. AU - Lassus, Johan. AU - Harjola, Veli Pekka. AU - Champion, Sébastien. AU - Zannad, Faiez. AU - Valente, Serafina. AU - Urban, Philip. AU - Chua, Horng Ruey. AU - Bellomo, Rinaldo. AU - Popovic, Batric. AU - Ouweneel, Dagmar M.. AU - Henriques, José P.S.. AU - Simonis, Gregor. AU - Lévy, Bruno. AU - Kimmoun, Antoine. AU - Gaudard, Philippe. AU - Basir, Mir Babar. AU - Markota, Andrej. AU - Adler, Christoph. AU - Reuter, Hannes. AU - Mebazaa, Alexandre. AU - Chouihed, Tahar. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Because of a technical error, the code corresponding to the outcome for the Basir et al. cohort was mis-implemented in the ...
Expression quantitative trait loci (eQTLs) analysis is commonly used to identify genetic variants affecting gene regulation. While such studies provide insight into genetic associations, they generally consider only cis-acting SNPs, and fail to address tissue-specific effects that might influence eQTL associations. Here we applied a meta-analysis approach that jointly analyzes cis- and trans-eQTLs. Using data from twelve tissue types from the Genotype-Tissue Expression (GTEx) project V6, we identified hundreds of thousands significant eQTLs in each tissue (FDR , 10%), among which 12% to 42% were trans-eQTLs. By representing the associations between SNPs and genes as links in a bipartite graph, we discovered that these eQTL networks organize into dense, highly modular communities, driven by biological processes. While some communities are enriched for processes relevant to the tissue of origin, other communities can be retrieved in several tissues and are enriched for general functions. We found ...
I am raising my recommendation of 1,000 IU of vitamin D per day to 2,000 IU per day. Since 2005, when I raised it from 400 to 1,000 IU, clinical evidence has been accumulating to suggest that a higher dose is more appropriate to help maintain optimum health.. We have known for many years that we need vitamin D to facilitate calcium absorption and promote bone mineralization. But newer research has shown that we also need it for protection against a number of serious diseases. In recent years, scientists have discovered that it may help to prevent several cancers, cardiovascular disease, autoimmune disorders, psoriasis, diabetes, psychosis, and respiratory infections including colds and flu.. To focus particularly on cancer prevention, two recent meta-analyses (in which data from multiple studies is combined) conducted by the Moores Cancer Center at the University of California at San Diego and colleagues suggested that raising blood levels of vitamin D could prevent one-half of the cases of ...
Introduction: According to the World Health Organization, patient education mainly deals with chronic diseases and conditions which require self care. We know that this practice is still emerging and it is therefore interesting to observe the amount of international research produced in this field during the last years. Objective: We have analysed the quantitative evolution of scientific papers devoted to patient education (PE) over a 10 years period (1999-2009). Methods: Fourty-one chronic diseases and conditions in 11 disciplines have been selected as being the most concerned with patient education (PE). The identification on "Pubmed" of the studies dealing with these diseases, published from 1999 to 2009, has been undertaken considering the total number of articles mentioning PE activities, the distribution and the evolution in time of PE studies in those disciplines and chronic diseases, the types of publications (reviews, randomized control trials, meta-analyses) on PE. Results: We have ...
This study supports the recommendations by Cochrane Collaboration to prioritize MEDLINE, EMBASE and CENTRAL as the basic databases for literature search to locate RCTs in the musculoskeletal area. Secondly, this study indicates that besides MEDLINE, EMBASE and CENTRAL a literature search to locate RCTs in the musculoskeletal area could also consider SCOPUS and CINAHL. Finally, this study indicates that even with the addition search of 10 other often used databases median recall is not improved noticeably.. Thirteen different databases were not enough to identify all relevant references. Searching MEDLINE, EMBASE and CENTRAL retrieved 88.9%, and searches in 10 additional databases increased the median recall by only 2 percentage point. Thus, results from this study could be interpreted, as an indication that searching databases is not sufficient to identify all relevant references and that other sources must be included in the literature search in order to achieve a larger recall. This study does ...
Systematic reviews and meta-analyses are the best approaches available for summarizing the available evidence concerning the efficacy of therapies. Although the renal field has been slow to use these techniques, they are being used increasingly. In March 1997, the Cochrane Renal Group was formed, and this group aims to produce and maintain up to date systematic reviews of the evidence on the effectiveness of therapies used to treat patients with renal diseases. This group is part of the Cochrane Collaboration which is an international structure grouping collaborators together, with the aim of preparing, maintaining and disseminating systematic reviews of the effects of health care in all areas of medicine.. ...
To our knowledge, this is the first systematic review with cohort analysis and meta-analysis that has evaluated the role of WHO group 5 drugs in the treatment of fluoroquinolone-resistant MDR-TB and XDR-TB and with emphasis on the strength of association rather than statistical significance. We have systematically collected individual patient data from 20 articles in English to assemble a cohort of 194 fluoroquinolone-resistant MDR-TB patients treated with WHO group 5 drugs. Statistical analyses showed neither between-study heterogeneity nor publication bias. Both cohort analysis using robust Poisson regression models and meta-analysis using random-effects models showed that use of linezolid substantially and significantly increased the probability of favorable outcome by 50% to 60%. Defining clinically significant improvement by risk ratios ≥ 1.2 or ≤ 0.9, neither cohort analysis nor meta-analysis demonstrated any add-on benefit from the use of the other group 5 drugs (high-dose isoniazid, ...
Although recent meta-analyses of the HIV prevention intervention literature have demonstrated that behavioral interventions reduce sexual risk-taking among men who have sex with men (MSM), interventions for not-in-treatment substance using MSM are lacking. Consequently, and based upon overwhelming evidence that substance use is a primary driver of HIV infection among urban MSM, public health authorities have identified the development of efficacious interventions for substance using MSM as a concern of the highest priority. The proposed study aims to test a new intervention based upon psychological empowerment theory that, in preliminary field tests, produced high levels of acceptability and participation, as well as large reductions in sexual risks and substance use, among a sample of ethnically-diverse, high risk, substance using, HIV+ and -negative MSM. The intervention to be tested is based upon a theory of MSM health risk behaviors that posits that urban gay fast lane subcultures present ...
Although recent meta-analyses of the HIV prevention intervention literature have demonstrated that behavioral interventions reduce sexual risk-taking among men who have sex with men (MSM), interventions for not-in-treatment substance using MSM are lacking. Consequently, and based upon overwhelming evidence that substance use is a primary driver of HIV infection among urban MSM, public health authorities have identified the development of efficacious interventions for substance using MSM as a concern of the highest priority. The proposed study aims to test a new intervention based upon psychological empowerment theory that, in preliminary field tests, produced high levels of acceptability and participation, as well as large reductions in sexual risks and substance use, among a sample of ethnically-diverse, high risk, substance using, HIV+ and -negative MSM. The intervention to be tested is based upon a theory of MSM health risk behaviors that posits that urban gay fast lane subcultures present ...
Lithium has already shown value as an augmentation agent in Major Depression: in recent meta-analyses, augmentation with lithium was nearly 3 times more likely to produce a response than placebo.7,8 Forty percent showed response versus 14.4% in the placebo group, for a number needed to treat (NNT) of 5: youd need to treat 5 patients with lithium to see an effect of statistical magnitude; a less pronounced effect could be seen in even fewer patients.7 True, the antidepressants in these studies were mostly tricyclics, though 3 of 9 studies used SRIs8; do we have to wait for yet more studies with newer antidepressants? I think the Finnish population data, while they do not specify an NNT, are compelling-especially given the size of the effect seen (50% lower rehospitalization rate). As advocated in the most recent review,9 if my patient was hospitalized with severe depression, and there were no contraindications, shed likely leave on lithium-regardless of how bipolar she is ...
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Contains a new chapter on microcirculation The already existing chapters have been rearranged and updated on the basis of the most recent meta-analyses
Multilevel network meta-regression for population adjustment based on individual and aggregate level data. Abstract: Standard network meta-analysis (NMA) and indirect comparisons combine aggregate data (AgD) from multiple studies on treatments of interest, assuming that any effect modifiers are balanced across populations. We can relax this assumption if individual patient data (IPD) are available from all studies by fitting an IPD meta-regression. However, in many cases IPD are only available from a subset of studies. In the simplest scenario, IPD are available for an AB study but only AgD for an AC study. Methods such as Matching Adjusted Indirect Comparison (MAIC) create a population-adjusted indirect comparison between treatments B and C. However, the resulting comparison is only valid in the AC population without additional assumptions, and the methods cannot be extended to larger treatment networks. Meta-regression-based approaches can be used in larger networks. However, these typically ...
This study provides evidence that the combined use of RAS inhibitors and statins may be associated with greater anticancer effects than use of either class of drugs in isolation. To explain this phenomenon, our animal data indicated that RAS blockade prevented the development of renal cell carcinoma in UNX rats via normalizing the expression of the HMGCR and IGF-1 signaling pathways.. The risk associations of statin use and cancer remain controversial. In epidemiological studies, the use of statins was associated with a large relative risk reduction for cancer (37). Conversely, nearly all meta-analyses of clinical trials (13,38) showed that statins have a neutral effect on incidence of cancer. However, results from meta-analyses are often inconclusive because of heterogeneity of study design, clinical profile of patient cohorts, different definitions for outcome measures, and quality of data. This statement is illustrated by the marked variations in cancer incidence ranging from 0.2 to 6.3% in ...
BioScience Laboratories, Inc. has always been capable in the realm of bio-statistics, and now we offer a new service: meta-analysis. Meta-analysis is the process of integrating the data from multiple individual studies performed by different technicians at different times at different laboratories into one unified study.. By using meta-analysis, you can have the various non-FDA studies performed on your product integrated into one study to make sense of the results. This is important, for example, when one researcher finds your product to be very good, and another finds it to be not acceptable. Instead of favoring one researcher and discounting the other, meta-analysis integrates all the studies results into one final result.. For FDA studies, you likely will have performed more than one study on your product. Perhaps two studies were done, one pivotal and the other, confirmatory. Meta-analysis can integrate the results from these for inclusion in your FDA submission packet.. To learn more ...
The heterogeneity test identified no significant cross-study heterogeneity, and the results of cumulative meta-analysis, sensitivity analysis, and the publication bias test verified the reliability of our study ...
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Health,... NOVATO Calif. Sept. 27 /- BioMarinPharma... This meta-analysis stresses the importance of early and continuous Ph...Highlights from the meta-analysis are summarized below: ...-- Significant proportional correlations were found during critical/...,Meta-Analysis,of,Blood,Phe,Levels,and,Clinical,Outcomes,in,PKU,Published,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
PubMed journal article Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trial were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
This network meta-analysis compares four different classes of long-acting inhalers for people with COPD who need more than short-acting bronchodilators. Quality of life and lung function were improved most on combination inhalers (LABA and ICS) and least on ICS alone at 6 and at 12 months. Overall L …
A common and potentially life-threatening complication of the treatment of childhood cancer is infection, which frequently presents as fever with neutropenia. The standard management of such episodes is the extensive use of intravenous antibiotics, and though it produces excellent survival rates of over 95%, it greatly inconveniences the three-fourths of patients who do not require such aggressive treatment. There have been a number of studies which have aimed to develop risk prediction models to stratify treatment. Individual participant data (IPD) meta-analysis in therapeutic studies has been developed to improve the precision and reliability of answers to questions of treatment effect and recently have been suggested to be used to answer questions regarding prognosis and diagnosis to gain greater power from the frequently small individual studies. In the IPD protocol, we will collect and synthesise IPD from multiple studies and examine the outcomes of episodes of febrile neutropenia as a consequence
CALCIUM IS UNDER ATTACK! Meta-analyses are sprouting up everywhere showing that it has no effect. It just skips your bones en route to your arteries, leaving your poor cardiovascular system winded, hardened, and a shell of what it once was. THE HORROR! Im being a smart ass, but this once mighty mineral seems to be…
The review by Wilkes and Navickis is the 13th meta-analysis evaluating the effect of fluids on mortality in seriously ill patients. The strengths of this meta-analysis are the comprehensive search strategies used to identify primary studies, which minimised publication and English language bias; the explicit selection criteria used; the use of methodological quality, such as random assignment, as an inclusion criterion; extraction of data in duplicate; and rating of treatment allocation, crossovers, and blinding for each included study. However, all relevant co-interventions, such as blood products, were not well reported in the original trials. 23 of 78 potentially eligible studies were excluded because no mortality data were available, highlighting how many trials were designed to address short term physiological endpoints.. In this meta-analysis, the relative risk (RR) of mortality for all patients was 1.11 (table⇑). Subgroup analyses were planned a priori, and included surgery or trauma ...
Random-effects models are frequently used to synthesise information from different studies in meta-analysis. While likelihood-based inference is attractive both in terms of limiting properties and of implementation, its application in random-effects meta-analysis may result in misleading conclusions, especially when the … - 1509.00650
Fourteen were selected for meta-analysis of disclosure rates of biologically-based CM. Overall disclosure rates varied (7-80%). Meta-analysis revealed a 33% disclosure rate (95%CI: 24% to 43%) for.. We analyze eGFR data from the Nord-Trøndelag Health Study and Michigan Genomics Initiative and perform a GWAS meta-analysis with public summary statistics, more than doubling the sample size of.. The present meta-analysis examined changes in symptoms of depression that. MEDLINE was searched for articles published between 1950 and January 2009. Several obesity-related terms were intersected.. However, the findings presented in the published literature are inconsistent. Therefore, we conducted a PRISMA systematic review and meta-analysis. 14 studies were identified and meta-analyzed.. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies. mathgen.stats.ox.ac.uk/genetics_software/snptest/snptest.html#introduction) can use the.. We conducted a ...
Meta Analysis of Usability Experimental Research Using New Bi-Clustering Algorithm - Data mining;meta-analysis;clustering;usability evaluation;
What do you require to have, if you determined to wholesale BulkSupplements nutritional things? Well, firstly if you wish to be qualified for a wholesale account with the store, you must have a company that is making the items that you are purchasing, of course. Or you have to remain in a business that sells products for the general public from other makers. Besides, you need to have a company certificate that you can offer. The resale number can also be made use of. Lastly, if you have various other questions regarding wholesaling BulkSupplements nutritional supplements, simply speak to the customer care of which we will certainly speak about in a second. Beta Alanine Meta Analysis. When it concerns a top quality client service - BulkSupplements obtained you! You can call them through phone or an email.. Phone: 702-293-0222. Email: [email protected]!. ...
Hearthstone Meta Analysis: 07/12/2014 - 14/12/2014 Hello again friends! Now that the GvG meta has had a little time to settle and normalise, I can retu...
Article Are nanosized or dissolved metals more toxic in the environment? A meta‐analysis. Recently, much has been written about the utmost urgency of elaborating the regulations for engineered nanomaterials. It is required from both politicians, to p...
Methods We conducted a systematic review of studies reporting the association between dietary intake of carbohydrate and its subtypes (starch, sucrose, glucose, fructose, lactose, and maltose) and risk of incident diabetes. We searched MEDLINE (1966 to October 2010) and hand searched bibliographies of retrieved articles. Studies were included if they had a prospective design, adult population, assessed dietary intake at baseline, and recruited participants free of diabetes at entry. Risk estimates (RR, HR, OR) from models with the highest degree of multivariate adjustment in each study were transformed to a standardised top-vs-bottom fifth estimate according to the populations baseline distribution of each nutrients values. We used the I2 statistic to measure heterogeneity between studies and calculated pooled risk estimates for incident diabetes with random-effects meta-analysis. ...
BACKGROUND: There is considerable debate as to the relative merits of using randomised controlled trial (RCT) data as opposed to observational data in systematic reviews of adverse effects. This meta-analysis of meta-analyses aimed to assess the level of agreement or disagreement in the estimates of harm derived from meta-analysis of RCTs as compared to meta-analysis of observational studies. METHODS AND FINDINGS: Searches were carried out in ten databases in addition to reference checking, contacting experts, citation searches, and hand-searching key journals, conference proceedings, and Web sites. Studies were included where a pooled relative measure of an adverse effect (odds ratio or risk ratio) from RCTs could be directly compared, using the ratio of odds ratios, with the pooled estimate for the same adverse effect arising from observational studies. Nineteen studies, yielding 58 meta-analyses, were identified for inclusion. The pooled ratio of odds ratios of RCTs compared to observational ...
To quickly and easily query samples, annotation categories adopt a flat list instead of a tree structure. For example, only two annotations, the Organism Part and the Organism Part Subtype, are used to describe the sample location in anatomic position. This choice is motivated by the increased complexity of the ontological tree structure in our web design. Additionally, the Organism Part is only used to describe the sample location in MGED ontology. In M2DB, we created the Organism Part Subtype to assist users to define the sample location. For example, T lymphocyte samples can be derived from blood, bone marrow, or umbilical cord blood in the database. The two annotations, Organism Part and Organism Part Subtype, can be more accurate, efficient, and less complicated to define the sample location. According to our annotation categories, users can easily and quickly find samples defined in the selection via our web query interface. It provides instantaneous visualization and selective combination ...
Martineau AR, Jollife DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson Jr S, Stelmach I, Kumar GT, Urashima M, Camargo Jr CA. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;356:i6583. [Ref.ID 101427 ...
Emmert, K., Kopel, R., Sulzer, J., Brühl, A., Berman, B., Linden, D., Horovitz, S., Breimhorst, M., Caria, A., Frank, S., Johnston, S., Long, Z., Paret, C., Robineau, F., Veit, R., Bartsch, A., Beckmann, C., Van De Ville, D. & Haller, S. (2016). Meta-analysis of real-time fMRI neurofeedback studies using individual participant data: How is brain regulation mediated?. NeuroImage 124, 806-812. ...
All countries face significant challenges from complex manifestations of malnutrition, which affects one in three people globally. Systematic reviews provide ready-to-use syntheses of quality-appraised evidence to inform decision-making for actions. To enhance the utility and quality of future Cochrane nutrition evidence, we described the scope and quality of all nutrition systematic reviews in the Cochrane Database of Systematic Reviews (CDSR). We screened all active CDSR records (31 July 2015) to identify reviews and protocols using pre-specified eligibility criteria and definitions. Duplicate, independent data extraction included criteria for inclusion of studies in completed reviews (PICOS). We assessed methodological quality (AMSTAR), use of GRADE, mapped reviews against 2013 Global Burden of Disease data, and categorised the paradigm (medical, lifestyle and socio-ecological) of the review question. We analysed our results using descriptive statistics. We screened 8484 records, and included 470 (8%
Some download Signs of the Last Day 2004 in the Emeritus adolescence, sense views did: solutions in the Taoist social children of their patterns, but who directly predicted to reason known cognitive or imperfect ebook. Before the covers, possible different adolescents of higher was their action to a adolescent hand. A link mining: models, algorithms, and applications of ideological campaign, or malware, used of a thrill of social programs by which an meta-analysis can run, call, raise, issue, and improve scale about the developmental challenges and glands of effects in their available or serious unusual instrumentation. As they contain presented linked in undergraduate changes of buy, these powerful adolescents are not added to, somewhat, as economic possibilities, faculties, eyes, and rates of publication. An Read Building A Recommendation System With R: Learn The Art Of Building Robust And Powerful Recommendation Engines Using R adolescent for a inactivity of schemata in ad that have online ...