Extracranial meningiomas are classified according to Hoye et al. [4]. Primary extracranial meningioma and secondary extracranial meningioma can be classified according to the presence or absence of an intracranial meningioma. Primary extracranial meningiomas are composed of two types: a tumor originating from arachnoid cells remaining in the nerve sheaths and a tumor occurring ectopically without connection to the cranium. Secondary extracranial meningiomas are classified as intracranial tumors directly escaping from the cranium and extracranial meningioma that has metastasized from an intracranial meningioma [6]. According to this classification, our case is classified as an ectopic primary extracranial meningioma.. Intradural meningioma is known to be associated with radiation, virus, head trauma, smoking, nitrate, and high cholesterol levels, but the cause of primary extracranial meningioma is not yet clear. Possible hypotheses are as follows: (1) migration of arachnoid cells along the ...
meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Cases reported • Meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
A meningioma is a type of brain tumor thats said to be to second most common type of brain tumor occurring in humans today. A meningioma brain tumor primarily develops in the meninges, the thin layers of tissue surrounding the spinal cord and the brain. In most cases, these brain tumors can grow in size and spread, although its difficult to determine the tumors growth rate. Upon growth, these tumors put pressure on surrounding brain tissue.. Meningiomas can be classified into three grades, as set by the World Health Organization. Grade I meningiomas are classified as benign, Grade II meningiomas are identified as atypical, while Grade III meningiomas are considered anaplastic. Meningiomas are usually benign, but Grade III meningiomas are malignant. The average survival rate for Grade III meningiomas, without relapse, is currently at about three years.. There are some factors that contribute to the development of brain tumors in the meninges. Excessive exposure to ionizing radiation or x-rays ...
Introduction: Meningiomas are predominantly benign tumors, which arise from the arachnoids cap cells. The development mechanism is unknown but they may result from an adverse effect of cranial irradiation and trauma. Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. Materials and Methods: This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. The study included samples from intracranial meningioma patients ...
This report presents magnetic resonance imaging (MRI) findings of a breast carcinoma metastasis in an intracranial meningioma with correlated pathological findings. MRI showed multiple foci of intense enhancement with hypointense surrounding areas. The described foci appeared to be metastatic disease from the patients known breast carcinoma. In addition, this is the first study reported in the literature to have investigated the expression of a possibly common carcinogenic molecule in breast carcinoma metastatic to a coexisting meningioma: overexpressed c-myc oncogene was found both in the breast carcinoma compartment and in the meningioma component of the tumor. ...
TY - JOUR. T1 - Single-fraction radiosurgery of benign intracranial meningiomas. AU - Pollock, Bruce E.. AU - Stafford, Scott L.. AU - Link, Michael J.. AU - Brown, Paul D.. AU - Garces, Yolanda I.. AU - Foote, Robert L.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - BACKGROUND:: Stereotactic radiosurgery (SRS) of benign intracranial meningiomas is an accepted management option for well-selected patients. OBJECTIVE:: To analyze patients who had single-fraction SRS for benign intracranial meningiomas to determine factors associated with tumor control and neurologic complications. METHODS:: Retrospective review was performed of 416 patients (304 women/112 men) who had single-fraction SRS for imaging defined (n = 252) or confirmed World Health Organization grade I (n = 164) meningiomas from 1990 to 2008. Excluded were patients with radiation-induced tumors, multiple meningiomas, neurofibromatosis type 2, and previous or concurrent radiotherapy. The majority of tumors (n = 337; 81%) involved the cranial base ...
TY - JOUR. T1 - Rhabdoid meningioma. T2 - Report of two cases. AU - Reddy, Ch Karunakar. AU - Divakar Rao, A.. AU - Ballal, Chandra K.. AU - Chakraborti, Shrijeet. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which on recurrence 18 months later, evolved into a rhabdoid meningioma. The second case in a 33-year-old male was located in the right parieto-occipital region.. AB - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which ...
MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability ...
Coexistence of pituitary adenoma, intracranial meningioma and cerebral aneurysm has never been described. We report on a patient with GH-secreting pituitary macroadenoma associated with a right...
Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013 Aug;68[8]:837-44. http://dx.doi.org/10.1016/j.crad.2013.03.007 PMid:23623578 Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. 2013;13(4):337. http://dx.doi.org/10.1007/s11910-013-0337-4 PMid:23463172 Osborn AG, Salzman KL, Barkovich AJ. Meningioma and atypical and malignant meningioma. In: Osborn AG, editor. Diagnostic imaging: brain. 2nd ed. Salt lake city: Lippincott Williams & Wilkins/Amirys, 2009: p. 72-81. de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J Clin Neurosci. 2009;16:1246 9. http://dx.doi.org/10.1016/j.jocn.2008.11.017 PMid:19560362 Goncalves AM, Page P, Domigo V, Meder JF, Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol. 2010;31:1504 5. http://dx.doi.org/10.3174/ajnr.A1978 PMid:20053802 Shimizu J, Matsumoto M, Yamazaki ...
Intracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles. Here, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors. We conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells
Request for free sample report: https://www.delveinsight.com/sample-request/meningioma-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Meningioma. 3. Competitive Intelligence Analysis for Meningioma. 4. Meningioma : Market Overview at a Glance. 4.1. Meningioma Total Market Share (%) Distribution in 2017. 4.2. Meningioma Total Market Share (%) Distribution in 2030. 5. Meningioma : Disease Background and Overview. 5.1. Introduction. 5.2. Sign and Symptoms 5.3. Pathophysiology 5.4. Risk Factors 5.5. Diagnosis 6. Patient Journey. 7. Meningioma Epidemiology and Patient Population. 7.1. Epidemiology Key Findings. 7.2. Assumptions and Rationale: 7MM. 7.3. Epidemiology Scenario: 7MM. 7.3.1. Meningioma Epidemiology Scenario in the 7MM (2017-2030). 7.4. United States Epidemiology. 7.4.1. Meningioma Epidemiology Scenario in the United States (2017-2030). 7.5. EU-5 Country-wise Epidemiology. 7.5.1. Germany Epidemiology. 7.5.1.1. Meningioma Epidemiology Scenario in Germany ...
Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients.. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and his team will determine the plasma exposure and brain accumulation of LEE011 following 5-day dosing in patients with recurrent atypical and malignant meningiomas; will evaluate select PD biomarkers corresponding to CDK4/6 inhibition, including Rb phosphorylation, cells in M-phase of cell cycle (PH3), and FoxM1 downregulation and explore the safety and efficacy of LEE011 in recurrent atypical and malignant meningioma with demonstrated pharmacokinetic and pharmacodynamic effects.. Dr. Sanai shares, What drives me forward is the opportunity to discover things that others in humankind have never seen, as we as find ...
A case of malignant meningioma which has grown rapidly after gross total removal and metastasized to thoracic spines after second operation is reported. We recommend that early spinal magnetic resonance image should be performed in patient with spinal symptoms and signs after the treatment of intracranial meningioma and intensive treatment combined with operation and radiosurgery should be performed for the reduction of growth rate in the recurred malignant meningoma. ...
Twenty four meningiomas (17 benign and seven atypical were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost exclusively of the CD8 subtype, were also present in 70% of benign meningiomas and in all atypical meningiomas and were more abundant in the latter. B lymphocytes were present in minimal numbers in three atypical meningiomas and in one benign meningioma. CD4 positive T lymphocytes were present in small numbers in one benign meningioma and in moderate numbers in one atypical meningioma. HLA DR antigen expression on tumour cells was present in about 60% of both tumour groups. The numbers of macrophages and T and CD8 lymphocytes in meningiomas seem to be related to atypical histological features, and the presence of these cells raises questions about host immune response and the relation of this to prognosis.. ...
Intraventricular Malignant Meningioma - Malignant meningioma· Intraventricle· Frontal horn· Third ventricle· Surgical approach.J Korean Neurosurg Soc 34 : 379-381;KISEP380 J Korean Neurosurg Soc 34Intraventricular Malignant Meningiomaand was removed a piecemealfashion using biopsy forceps
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state. Consistent with this observation, atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks. Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. Our results ...
Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, 10% are classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas. Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon. Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation. Here, we report that additional nullizygosity for p16Ink4a increases the frequency of meningioma and meningothelial proliferation in these mice without modifying the tumor grade. In addition, by using ...
Temporal bone meningioma can be considered as a part of the ectopic meningioma group. The known female preponderance of intracranial meningiomas is also seen in external auditory canal meningioma.4 Up to 20% of intracranial meningiomas may have extraneuraxial extension, 5,6,7,8. including the skull, scalp (all cutaneous sites), orbit, upper airway involvement (nasal cavity, paranasal sinuses, nasopharynx), soft tissues, and ear / temporal bone. However, when the scalp, orbit, sinonasal tract, oral cavity, and soft tissues are excluded, the incidence decreases to ,1% 6, 9, 10, 11. Ectopic or extracranial meningiomas are classified into 4 subgroups: direct extension from primary intracranial meningioma, extracranial growth from cranial nerve sheath arachnoidcells, extracranial extension from embryonic arachnoid rests without connection to the skull base or cranial nerves, and distant metastasis from intracranial tumors.3 Meningioma gains access to the temporal bone from 3 principal sites of ...
Introduction Forkhead Box M1 (FOXM1) and aryl hydrocarbon receptor (AHR) signaling pathway participate in meningioma development, but their correlation was inadequately studied. The study is aimed to uncover their functions and correlation in malignant meningioma. Material and methods...
Background: Meningioma is one of the primary brain tumors that most often occurs at the age of 60-70 years, originating from arachnoid cap cells. FGF-2 as a growth factor is a potent stimulator of endothelial proliferation which is very important in the process of angiogenesis. FGF-2 levels in meningiomas have been assessed using the ELISA and qrPCR methods in many previous studies using blood serum in malignant cases with normal brain tissue as control. This study used tissue samples of meningioma tumors in which most cases of meningioma are benign. Objective: To assess the association between immunohistochemical expressions of FGF-2 and histopathology grade among meningioma patients. Material and Method: Formalin-fixed paraffin-embedded tissue blocks of 32 meningioma patients were immunohistochemically studied for FGF-2 expression. The basic characteristics of the samples were obtained through medical records or pathology archieves. The association between FGF-2 expression and grade were ...
TY - JOUR. T1 - Preoperative Embolization of Intracranial Meningiomas. AU - Yoshida, Kazunari. AU - Toya, Shigeo. AU - Takamiya, Yoshiaki. AU - Murakami, Hideki. AU - Kawase, Takeshi. AU - Shiga, Hayao. PY - 1985. Y1 - 1985. N2 - The method and results for preoperative embolization are described in 36 cases with intracranial meningiomas. Embolization materials were injccted through a transfemoral catheter, selectively placed in the external carotid artery. Chopped gelfoam served as embolization material in 29 patients and ivalon particles were used in 7 patients. In 19 out of 36 cases the feeding arteries arose only from the external carotid artery system and were completely occluded (complete embolization) except in 3 cases. The remaining 17 cases also had feeders of the tumor capsule or at the site of the insertion arising from the internal carotid artery system (partial embolization). Thirty-three cases were followed by computed tomography (CT) between embolization and operation. Contrast ...
Meningioma Mommas is asking for help to fund an exciting new project by the team of University of Colorado researchers we have previously funded. Please help us help the researchers find better treatment options for meningioma patients by donating here or via our own Donate page.. From the researchers:. PROJECT SUMMARY. Meningiomas are a common brain tumor, considered to be the most prevalent primary brain tumor in the central nervous system. In spite of their burden, no FDA approved pharmacotherapies exist for the treatment of these tumors. Through our work with Meningioma Mommas, we have created a high throughput drug screen that allows us to directly measure the sensitivity of individual tumors to hundreds of FDA approved compounds. This approach has identified several possible treatments that have the ability to treat meningiomas broadly by targeting epigenetic processes. Many of the drugs in this class can cross the blood brain barrier making these ideal candidates for further studies. ...
Meningioma is the most common extra-axial benign brain tumor. It is more common in females than males. Meningioma has both typical and atypical features. The diagnosis of typical meningioma is easier than atypical. Major differential diagnoses fo...
TY - JOUR. T1 - Metastatic meningioma in fine-needle aspiration (FNA) of the lung. T2 - Cytomorphologic finding. AU - Baisden, Blaire L.. AU - Hamper, Ulrike M.. AU - Ali, Syed Z.. PY - 1999/5. Y1 - 1999/5. N2 - Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellularity with large syncytial groups of monomorphic cells with epithelioid morphologic features, often in perivascular arrangements. Occasional intranuclear cytoplasmic inclusions as well as binucleated cells with wispy cytoplasmic extensions were also noted. Immunoperoxidase studies showed focal positivity for epithelial membrane antigen. The differential diagnosis includes primary or metastatic adenocarcinoma, malignant mesothelioma, and melanoma.. AB - Pulmonary metastasis ...
Anaplastic meningiomas (also known as malignant meningiomas) are uncommon, accounting for only ~1% of all meningiomas 1. Along with rhabdoid meningioma and papillary meningioma are considered WHO grade III tumors and demonstrate aggressive local ...
Meningiomas, which invade intracranial bone structures and the adjacent connective tissue, are frequently unresectable because of their aggressive and recalcitrant growth behavior. They have a high recurrence rate, and in approximately 10% of these tumors there is an increased risk of malignancy. Significant morbidity and mortality rates associated with recurrent meningiomas demand nonsurgical approaches. To date, adjuvant hormonal treatment has not proven beneficial. The anticancer drug hydroxyurea was therefore tested for its potential use in the treatment of meningiomas.. Early-passaged cell cultures were established from 20 different meningiomas. The addition of 5 X 10−4 and 10−3 M hydroxyurea over a period of 5 to 9 days resulted in a remarkable decrease in cell proliferation and even blocked tumor cell growth when compared with untreated cells. A significant arrest of meningioma cell growth in the S phase of the cell cycle was revealed on DNA flow cytometry.. Electron micrographs of ...
The aim of this work was to study the vascular endothelial growth factor A (VEGF-A) pathway and peritumoral brain edema (PTBE) through comparison of non-angiomatous and angiomatous meningiomas. Meningiomas are common intracranial tumors, which often have PTBE. VEGF-A is an integral part of PTBE formation and angiogenesis, and the capillary-rich angiomatous meningiomas are known for their PTBE. The VEGF-A receptor VEGFR-2 is responsible for the angiogenic effect of VEGF-A on endothelial cells, which is enhanced by the co-receptor neuropilin-1. Forty non-angiomatous, 22 angiomatous meningiomas, and 10 control tissue samples were collected for the study. Magnetic resonance images were available for 40 non-angiomatous and 10 angiomatous meningiomas. Tissue sections were immunostained for CD34, MIB-1, estrogen- and progesterone receptors. ELISA, chemiluminescence, and RT-qPCR were used for VEGF-A, VEGFR-2, and neuropilin-1 protein and mRNA quantification. Angiomatous meningiomas had larger PTBE (695 ...
BackgroundTo study the association between use of wireless phones and meningioma.MethodsWe performed a case-control study on brain tumour cases of both genders aged 18-75 years and diagnosed during 2007-2009. One population-based control matched on gender and age was used to each case. Here we report on meningioma cases including all available controls. Exposures were assessed by a questionnaire. Unconditional logistic regression analysis was performed.ResultsIn total 709 meningioma cases and 1,368 control subjects answered the questionnaire. Mobile phone use in total produced odds ratio (OR) = 1.0, 95% confidence interval (CI) = 0.7-1.4 and cordless phone use gave OR = 1.1, 95% CI = 0.8-1.5. The risk increased statistically significant per 100 h of cumulative use and highest OR was found in the fourth quartile (|2,376 hours) of cumulative use for all studied phone types. There was no statistically significant increased risk for ipsilateral mobile or cordless phone use, for meningioma in the temporal
Meningiomas are uncommonly associated with cysts and account for 1.6-10% of intracranial meningiomas 1) 2) 3) Those with more numerous smaller peripheral cysts are more frequent (8-23% of cases). They are over-represented in male patients and the paediatric population Clinical presentation Patients present clinically in the same way as patients with non-cystic meningiomas, with either symptoms related to increased intracranial pressure (ICP), focal neurology, or seizures. Pathology Various mechanisms have been proposed, and probably more than one is applicable depending on the location of the cysts: degeneration or necrosis direct secretion by meningioma reactive changes (peripheral arachnoid cysts) Classification Nauta et al. divided cystic meningiomas into four subtypes according to the location of the cyst with respect to the brain and meningioma type 1: intratumoral cyst(s), located centrally within the meningioma type 2: intratumoral cyst(s), situated peripherally within the meningioma but ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates from the arachnoid (not the dura), the tissue covering the brain and spinal cord lying deep to the dura. Meningiomas are much more common in females, and are more common after 50 years of age. Of all cranial meningiomas, about 20% of them are in the sphenoid wing. In some cases, deletions involving chromosome 22 are involved. Sphenoid wing meningiomas are diagnosed by the combination of suggestive symptoms from the history and physical and neuroimaging by magnetic resonance imaging (MRI) or computer averaged tomography (CT). Tumors growing in the inner wing (clinoidal) most often cause direct damage to the optic nerve leading especially to a decrease in visual acuity, progressive loss of color vision, defects in the field of vision (especially cecocentral), and an afferent pupillary defect. If the tumor continues to grow and push on the optic nerve, all vision will be ...
Meningiomas are tumours of the membranes that cover the brain. Meningiomas are described as atypical when the tumor cells do not appear typical or normal. The standard treatment for patients with atypical meningioma is surgery to remove the tumour. Radiotherapy to kill any tumour cells left behind after surgery (post-operative radiotherapy) can increase the patient survival rate. The aim of this study is to find out whether a form of radiotherapy called carbon ion boost in combination with post-operative photon radiotherapy can improve the patient survival rate after 3 years ...
TY - JOUR. T1 - Fatal hemorrhagic infarction of posterior fossa meningioma during cardiopulmonary bypass. AU - Sun, Hai. AU - Ross, Donald (Don). PY - 2012/2. Y1 - 2012/2. N2 - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a suprasellar meningioma, hemiparesis after mitral valve replacement with recovery after resection, and non-fatal hemorrhage into a posterior fossa meningioma. The largest report of 16 patients with known meningiomas over 11 years suggested a benign course, with no new neurologic symptoms and no required resection of a meningioma over an average follow-up of 31 months. In 2 cases we report a presumed posterior fossa meningioma led to fatal outcome after cardiac surgery performed on bypass. Possible causes and future considerations are discussed.. AB - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a ...
TY - JOUR. T1 - Anatomic location is a risk factor for atypical and malignant meningiomas. AU - Kane, Ari J.. AU - Sughrue, Michael E.. AU - Rutkowski, Martin J.. AU - Shangari, Gopal. AU - Fang, Shanna. AU - McDermott, Michael W.. AU - Berger, Mitchel S.. AU - Parsa, Andrew T.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/3/15. Y1 - 2011/3/15. N2 - BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I meningiomas after surgery and/or external irradiation. As the utility of noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess the likelihood that a tumor is not benign before treatment initiation. Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location. METHODS: The authors reviewed 378 patients presenting at their institution from 2000 to 2007 with histologically ...
Background: Concomitant dural arteriovenous fistulas (DAVFs) and meningiomas have been rarely described. DAVFs can be either continuous or at a distant location from the meningioma, with different pathophysiologic mechanisms involved in each situation.. Case Description: We report the case of a 74-year-old woman presenting with left-sided hemiparesis secondary to a large right convexity meningioma, associated with a noncontiguous Borden 3 DAVF. Both lesions were treated surgically in the same setting. The patient improved after surgery, and postoperative imaging showed complete resection of the meningioma and absence of recurrence of the fistula at 4 years.. Conclusion: To the best of our knowledge, this is the first case of concomitant surgical treatment of a meningioma and noncontiguous DAVF.. Keywords: Dural arteriovenous fistula, DAVF, Meningioma, Vascular malformations. ...
BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed ...
TY - JOUR. T1 - SINDROME DI WERNER E MENINGIOMA INTRACRANICO. AU - Borroni, G.. AU - Vignati, G.. AU - Zaccone, C.. AU - Brazzelli, V.. AU - Scappaticci, S.. AU - Cerimele, D.. AU - Rabbiosi, G.. PY - 1989. Y1 - 1989. N2 - A case of Werners Syndrome in a 47-year-old man, with typical features of pangeria associated with intracranial meningioma is described. A review of the literature showed that meningioma is the most frequent benign neoplasm in Werners Syndrome. Meningioma is a peculiar model of neoplasm, because of the frequency of cytogenetical aberrations concerning chromosome n. 22. Either chromosome n. 22 and other chromosomal alterations could be detected in peripheral blood lymphocytes of our patient. These findings suggest a correlation between chromosomal instability and the onset of neoplasms in Werners Syndrome. Furthermore, the possibility of detecting chromosome n. 22 aberrations in peripheral blood lymphocytes of Werners Syndrome patients could provide a clue to the presence ...
Primary extradural meningiomas are rare, accounting for less than 2% of all meningiomas; most cases involve the skull. A review of 169 cases was published by Lang et al.2 Only 3 cases of primary meningioma involving the mandible have been reported so far. The first case was by Landini and Kitano in 19923; another 2 cases were by Jones and Freedman in 2001.4 All patients, including ours, were women, and the radiographic presentation was a lytic lesion. Three cases of extracranial meningioma of the maxilla have been reported, excluding cases within the paranasal sinuses. A male patient presented with an oral lesion and a multilocular radiolucency on a periapical x-ray film.5 In 2 female patients, dental x-ray demonstrated a mixed radiolucent-radiopaque mass6 with ill-defined margins in 1 patient.7. To our knowledge, the appearance of mandibular meningioma in CT and MR imaging has not been previously reported.. The lesion in our patient appeared as a cystic lesion of the mandibular body on ...
MENINGIOMA. Meningiomas are extra-axial tumours and represent the most common tumour of the meninges. They are a non-glial neoplasm that originates from the arachnoid cap cells of the meninges. They are typically benign with a low recurrence rate but rarely can be malignant.. Typical meningiomas appear as dural based masses isointense to grey matter on both T1 and T2 weighted imaging, and demonstrate vivid contrast enhancement on both MRI and CT. There are, however, many variants some of which can vary dramatically in their imaging appearance. Epidemiology. Meningiomas are more common in women, with a ratio of 2:1 intracranially and 4:1 in the spine. Atypical and malignant meningiomas are slightly more common in males. They are uncommon in patients before the age of 40 and should raise suspicion of neurofibromatosis type 2(NF2) when found in young patients.. Grading. Generally follows the WHO classification for CNS tumours:. ...
2Hacettepe Üniversitesi Tıp Fakültesi Beyin Cerrahisi Anabilim Dalı, Ankara Meningiomas represent approximately 13-26% of primary intracranial tumours. Many small meningiomas have no symptoms during life and may be found incidentally at autopsy. Such incidental meningiomas are detected more frequently in recent years because of the advent of CT and MRI. Malignant (anaplastic) meningiomas are less common lesions, accounting for 1-2.8% of meningiomas. Recently, clear cell and chordoid meningiomas have been classified as WHO Grade II and rhabdoid and papillary meningiomas classified as WHO Grade III tumors without pathological criteria for malignancy. Here we report a rare case of rhabdoid meningioma in a 31 year-old man. Using the presented case we discuss the prognostic significance of recognition of a rhabdoid meningioma in light of the literature. Anahtar Kelimeler : Meningioma, rhabdoid meningioma, prognostic significance ...
TY - JOUR. T1 - Optic nerve seeding of atypical meningiomas presenting with subacute visual loss. T2 - 2 case reports with genetic characterization. AU - Kitamura, Yohei. AU - Akiyama, Takenori. AU - Sasaki, Hikaru. AU - Hayashi, Yuichiro. AU - Yoshida, Kazunari. PY - 2013/8. Y1 - 2013/8. N2 - Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical ...
Meningiomas account for around 25% of primary brain tumours, and most often occur between the age of 40 and 70 years. They are more common in females. Atypical meningiomas are more aggressive than benign meningiomas, and account for around 5% of all meningiomas. Around 4% of meningiomas are malignant ...
Secretory meningioma is a distinct subtype of meningioma. We describe the cytologic features of a secretory meningioma on squash preparations, in comparision with other cytologic mimickers. A 54-year-old woman presented with hearing loss, vertigo, tinnitus, and headache for seven years. A brain MRI study revealed a 4.5 cm sized mass in the cerebellopontine angle, which showed homogenous signal intensity in T2-weighted image. The intraoperative squash smear showed some well-defined, thin rimmed intracytoplasmic inclusions, containing a finely granular eosinophilic core among less cohesive meningiomatous cells. Histologic sections revealed a meningothelial meningioma with scattered inclusions, with periodic acid-Schiff, carcinoembryonic antigen, and cytokeratin positivity. Identification of characteristic intracytoplasmic inclusions is helpful for diagnosing secretory meningiomas. On squash preparations, differential diagnoses included tumors with inclusions or cytoplasmic vacuolizations, such as ...
TY - JOUR. T1 - Cognitive outcomes in meningioma patients undergoing surgery. T2 - Individual changes over time and predictors of late cognitive functioning. AU - Rijnen, S.. AU - Meskal, I.. AU - Bakker, M.. AU - Rutten, G.. AU - Gehring, K.. AU - Sitskoorn, M.. PY - 2018. Y1 - 2018. U2 - 10.1093/neuonc/noy139.387. DO - 10.1093/neuonc/noy139.387. M3 - Meeting Abstract. VL - 20. SP - iii317-iii317. JO - Neuro-Oncology. JF - Neuro-Oncology. SN - 1522-8517. IS - suppl 3. ER - ...
TY - THES. T1 - Cognitive functioning in meningioma patients. T2 - Insights in individual test performances and changes of performance after surgery. AU - Meskal, Ikram. PY - 2018. Y1 - 2018. M3 - Doctoral Thesis. SN - 978-94-6375-224-4. PB - Ridderprint. CY - s.l.. ER - ...
Background: Meningioma is a frequent primary intracranial tumor, the etiology of which is potentially related to adiposity. Metabolic syndrome (MetS) is an increasingly common disease characterized by having at least three of the following conditions: central adiposity, arterial hypertension, dyslipidemia, and insulin resistance. Only one prior study investigated MetS in relation to meningioma risk and found a positive association between the two. Results: Among 2,027 cases and 20,269 controls, body mass index was positively associated with meningioma (p-value for trend , 0.0001). Arterial hypertension was also associated with an increased risk of meningioma (OR = 1.34; 95% CI = 1.20-1.49). By comparison, high-density lipoprotein, triglycerides, fasting serum glucose, and use of ACE-inhibitors, AT-II inhibitors, beta-blockers, diuretics, calcium antagonists, nitrates, or statins were not associated with risk of meningioma. Materials and Methods: We conducted a matched case-control analysis using ...
Optic nerve sheath meningiomas and optic nerve gliomas can be difficult to differentiate by computed tomography (CT). Three patients with optic nerve sheath meningiomas were studied with a CT/T 8800 scanner with 1.5-mm-thick axial sections and intravenous contrast material. In each case, an abnormal optic nerve sheath was identified by CT. A soft-tissue mass arose from one side of the sheath in one patient, and the entire sheath was enlarged in two patients. This provides a basis for distinguishing optic nerve sheath meningioma from optic nerve glioma. ...
TY - JOUR. T1 - Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis. T2 - case report. AU - Pozzati, Eugenio. AU - Zucchelli, Mino. AU - Schiavina, Mario. AU - Contini, Paola. AU - Foschini, Maria Pia. PY - 2007/12. Y1 - 2007/12. N2 - Background: Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. Case Description: We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. Conclusions: This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.. AB - Background: ...
TY - JOUR. T1 - Optic nerve sheath meningiomas. T2 - Visual improvement after stereotactic radiotherapy. AU - Liu, James K.. AU - Forman, Scott. AU - Hershewe, Gerard L.. AU - Moorthy, Chitti R.. AU - Benzil, Deborah L.. AU - Kondziolka, Douglas. AU - Adler, John R.. AU - Loeffler, Jay S.. AU - Gutin, Philip H.. AU - Pollock, Bruce E.. PY - 2002/5/1. Y1 - 2002/5/1. N2 - OBJECTIVE: The management of primary optic nerve sheath meningioma (ONSM) is controversial. Surgery often results in postoperative blindness in the affected eye and thus has been abandoned as a treatment option for most patients. When these tumors are left untreated, however, progressive visual impairment ensues, which also leads to blindness. Recently, radiation therapy has gained wider acceptance in the treatment of these lesions. Experience with stereotactic radiotherapy (SRT) in the treatment of ONSMs is limited because of the rare incidence of this tumor. We present a series of patients with ONSM who were treated with SRT. ...
TY - JOUR. T1 - Precision radiation therapy for optic nerve sheath meningiomas. AU - Eng, Tony Y.. AU - Albright, N. W.. AU - Kuwahara, G.. AU - Akazawa, C. N.. AU - Dea, D.. AU - Chu, G. L.. AU - Hoyt, W. F.. AU - Wara, W. M.. AU - Larson, D. A.. PY - 1992. Y1 - 1992. N2 - A more precise radiation therapy technique to treat unilateral optic nerve sheath meningioma is presented. It uses an immobilization device to align the ipsilateral optic nerve with a vertical axis and employs three small half-beam blocked fields to deliver radiation to a small conformal volume, thereby reducing the dose to the optic chiasm and the contralateral optic nerve. Three patients were successfully treated with this technique, and a fourth patient with optic nerve glioma was also treated in a similar fashion and was included in this study. The new technique irradiates a much smaller volume of tissue to high dose levels: 58 cm3 is irradiated to the 80% isodose level and only 18 cm3 to the 95% level. In contrast, the ...
Meningioma is a primary central nervous tumour (CNS) affecting mostly adults. Skull base meningiomas cause morbidity (and occasionally mortality) by compressing adjacent critical organs, and the aim of treatment is to optimise and preserve CNS function. Radiotherapy is an effective treatment for meningioma, with doses of 50-54Gy in conventional fractionation schedules resulting in long-term local control rates of 80-90%. However, local recurrence is unacceptably high in aggressive histological subtypes (WHO G2 and G3), and these patients have a poor outcome following standard dose regimens. In recent years Intensity-Modulated Radiotherapy (IMRT) has been developed, and can deliver highly conformal dose distributions with sharp dose gradients, making dose escalation a possibility for many tumours, including those located in the skull base. The aim of this thesis was to address two issues pertaining to the role of radiotherapy for skull base meningioma. Firstly the goal was to investigate the ...
Hey guys! I am 37 years old & was recently diagnosed with an optic nerve sheath Meningioma. In a matter of three years I have lost all vision in my right eye. Most would think, as I did, you have 2 eyes- youll be okay with just one & boy […]
TY - JOUR. T1 - Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas. AU - Komotar, Ricardo J.. AU - Starke, Robert M.. AU - Raper, Daniel M.S.. AU - Anand, Vijay K.. AU - Schwartz, Theodore H.. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Objective: To assess the advantages and limitations of the endoscopic endonasal approach to anterior skull base meningiomas, a minimally invasive approach that avoids extensive bone drilling, brain retraction, and manipulation of nerves and critical vessels, versus open transcranial surgery. Methods: A MEDLINE (2000-2010) search was performed to identify series for either olfactory groove meningiomas or tuberculum sellae (TS) or planum sphenoidale meningiomas. Statistical analyses of categorical variables such as extent of resection, morbidity, and visual outcome were performed using χ 2 and Fisher exact tests. Results: The literature review included 60 studies, involving 1426 patients. Open surgery achieved a higher rate ...
Management of Recurrent Skull Base Meningiomas Keywords: anaplastic, atypical, chemotherapy, endoscopic surgery, meningioma, microsurgery, minimally-invasive, radiosurgery, recurrence, skull base Sheri K. Palejwala, Garni Barkhoudarian, Walavan Sivakumar, Daniel F. Kelly Abstract Skull base meningiomas, due to their frequent investment or encasement of critical neurovascular structures, are challenging to resect in their entirety, both with initial resection…
Definition of meningotheliomatous meningioma. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
IMPORTANCE Diagnostic errors can lead to the initial misdiagnosis of optic nerve sheath meningiomas (ONSM), which can lead to vision loss. ...
TY - JOUR. T1 - Addressing Misdiagnosis of Optic Nerve Sheath Meningiomas. AU - Kalen, Brian D.. AU - Hess, Ryan A.. AU - Abi-Aad, Karl R.. AU - Welz, Matthew E.. AU - Patra, Devi P.. AU - Sharma, Akanksha. AU - Mrugala, Maciej M.. AU - Porter, Alyx B.. AU - Bendok, Bernard R.. AU - Acierno, Marie D.. PY - 2020/1. Y1 - 2020/1. UR - http://www.scopus.com/inward/record.url?scp=85076866243&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85076866243&partnerID=8YFLogxK. U2 - 10.1016/j.wneu.2019.10.122. DO - 10.1016/j.wneu.2019.10.122. M3 - Article. C2 - 31881557. AN - SCOPUS:85076866243. VL - 133. SP - 419. EP - 420. JO - World Neurosurgery. JF - World Neurosurgery. SN - 1878-8750. ER - ...
The authors present the technical and anatomical nuances needed to perform an endoscopic endonasal removal of a tuberculum sellae meningioma. The patient is a 47-year-old female with headaches and an incidental finding of a small tuberculum sellae meningioma with no vascular encasement, no optic canal invasion, but mild inferior to superior compression of the cisternal segment of the left optic nerve. Neuroophthalmology assessment revealed no visual defects. Treatment options included clinical observation with imaging follow-up studies, radiosurgery, and resection. The patient elected to undergo surgical removal and an endonasal endoscopic approach was the preferred surgical option. Preoperative radiological studies showed the presence of an osseous ring between the left middle and anterior clinoids, the so-called carotico-clinoidal ring. The surgical implications of this finding and its management are illustrated. The surgical anatomy of the suprasellar region is reviewed, including concepts ...
To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning. For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in
TY - JOUR. T1 - Endoscopic transsphenoidal resection of a mid-clival meningioma. AU - Alexander, Hamish. AU - Robinson, Simon. AU - Wickremesekera, Agadha. AU - Wormald, Peter. PY - 2010/3. Y1 - 2010/3. N2 - Advances in transsphenoidal endoscopic surgery have allowed difficult clival tumours such as meningiomas causing effacement of the pons and basilar artery to be approached by this technique. We report a clival meningioma resected via a transsphenoidal endoscopic approach.. AB - Advances in transsphenoidal endoscopic surgery have allowed difficult clival tumours such as meningiomas causing effacement of the pons and basilar artery to be approached by this technique. We report a clival meningioma resected via a transsphenoidal endoscopic approach.. KW - Clivus. KW - Endoscope. KW - Meningioma. KW - Transsphenoidal approach. UR - http://www.scopus.com/inward/record.url?scp=75349085050&partnerID=8YFLogxK. U2 - 10.1016/j.jocn.2009.06.037. DO - 10.1016/j.jocn.2009.06.037. M3 - Article. VL - ...
Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60-70% of cases occur in middle age females, and is more common in older adults (mean age 44.7 years). It is also seen in children, but this is rare. The tumors grow from cells that surround the optic nerve, and as the tumor grows, it compresses the optic nerve. This causes loss of vision in the affected eye.[1] Rarely, it may affect both eyes at the same time.[2] It is typically a slow growing tumor, and has never been reported to cause death. However, there is concern that the tumor can grow into the brain and cause other types of neurological damage. In some patients, the tumor grows so slowly that treatment is not necessary. Standard treatments are observation, surgery, radiation therapy, and combinations of the above.[1] ...
Detection of TP53 gene mutation in human meningiomas: A study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples ...
Contents: The Fundamentals.- The History of Stereotactic Radiosurgery.- Neuroimaging in Radiosurgery Treatment Planning and Follow-up Evaluation.- Techniques of Stereotactic Radiosurgery.- Radiation Biology and Physics.- The Physics of Stereotactic Radiosurgery.- Radiobiological Principles Underlying Stereotactic Radiation Therapy.- Experimental Radiosurgery Models.- Treatment Planning for Stereotactic Radiosurgery.- Designing, Building and Installing a Stereotactic Radiosurgery Unit.- Stereotactic Radiosurgery Techniques.- Gamma Knife Radiosurgery.- Linear Accelerator Radiosurgery.- Proton Beam Radiosurgery: Physical Bases and Clinical Experience.- Robotics and Radiosurgery.- CyberKnife Radiosurgery.- Treatment of Disease Types.- Brain Metastases.- Metastatic Brain Tumors: Surgery Perspective.- Brain Metastases: Whole-Brain Radiation Therapy Perspective.- High-Grade Gliomas.- Malignant Glioma: Chemotherapy Perspective.- Meningioma.- Meningioma: Surgery Perspective.- Intracranial Meningioma: ...
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The authors report a novel technique of balloon-assisted embolization of a skull base meningioma supplied by a branch of the cavernous segment of the internal carotid artery using liquid embolic agent. A temporarily inflated balloon distal to the meningiomas feeding vessel may improve the access to this small branch and may reduce the chances of unintended reflux during delivery of the liquid embolic agent. ...
TY - JOUR. T1 - Morbidity and mortality associated with meningioma after cranial radiotherapy. T2 - A report from the childhood cancer survivor study. AU - Bowers, Daniel C.. AU - Moskowitz, Chaya S.. AU - Chou, Joanne F.. AU - Mazewski, Claire M.. AU - Neglia, Joseph P.. AU - Armstrong, Gregory T.. AU - Leisenring, Wendy M.. AU - Robison, Leslie L.. AU - Oeffinger, Kevin C.. PY - 2017/5/10. Y1 - 2017/5/10. N2 - Purpose: Little is known about neurologic morbidity attributable to cranial radiotherapy (CRT) -associated meningiomas. Materials and Methods: From 4,221 survivors exposed to CRT in the Childhood Cancer Survivor Study, a diagnosis of meningioma and onset of neurologic sequelae were ascertained. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% CIs to evaluate the factors associated with neurologic sequelae after subsequent meningioma. Results: One hundred ninety-nine meningiomas were identified among 169 participants. The median interval from primary ...
TY - JOUR. T1 - Skull base meningiomas. AU - Couldwell, William T.. AU - Heros, Roberto. AU - Dolenc, Vinko. PY - 2011/5. Y1 - 2011/5. UR - http://www.scopus.com/inward/record.url?scp=84858619086&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84858619086&partnerID=8YFLogxK. U2 - 10.3171/2011.3.FOCUS1185. DO - 10.3171/2011.3.FOCUS1185. M3 - Editorial. C2 - 21529181. AN - SCOPUS:84858619086. VL - 30. JO - Neurosurgical Focus. JF - Neurosurgical Focus. SN - 1092-0684. IS - 5. ER - ...
TY - JOUR. T1 - Intratumoral microhemorrhages on T2*-weighted gradient-echo imaging helps differentiate vestibular schwannoma from meningioma. AU - Thamburaj, K.. AU - Radhakrishnan, V.V.. AU - Thomas, B.. AU - Nair, S.. AU - Menon, G.. N1 - cited By 43. PY - 2008. Y1 - 2008. N2 - BACKGROUND AND PURPOSE: Vestibular schwannomas (VS) may be difficult to differentiate from cerebellopontine angle (CPA) meningiomas. Demonstration of microhemorrhages in VS on T2*-weighted gradient-echo (GRE) sequences may have potential value to differentiate VS from CPA meningiomas. MATERIALS AND METHODS: In this prospective study of 20 patients, MR imaging was performed with T2*-weighted GRE in addition to all basic sequences. Histopathologic examination was performed after surgery. Intratumoral hemosiderin was confirmed by pigment staining. RESULTS: There were 15 patients in the VS group with 16 VS and 5 in the meningioma group with 5 posterior fossa meningiomas. Fourteen of the 16 VS and all 5 meningiomas were ...
MORALES, F. et al. Skull base meningiomas: a predictive system to know the extent of their surgical resection and patient outcome. Neurocirugía [online]. 2005, vol.16, n.6, pp.477-485. ISSN 1130-1473.. Objective. The aim of this study was to build a preoperative predictive system which could pro-vide reliable information about: 1° which skull base meningiomas can be total or partially removed, and 2° their surgical outcome. Method. Patient histories and imaging data were reviewed retrospectively from 85 consecutive skull base meningiomas patients who underwent surgery from 1990 and 2002. From the preoperative data, nine variables were selected for conventional statistical analysis as regards their relationship with: 1° total vs partial tumor resection and 2° with patients outcome according to the degree of tumour removal. Results. From the nine variables analysed only two had a statistical association with the type of tumour resection performed (total vs partial) and the patient outcome: 1) ...
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Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the central nervous system. They arise from the arachnoid cap cells of the arachnoid villi in the meninges. These tumors usually are benign in nature; however, a small percentage are malignant. Many meningiomas produce no symptoms throughout a persons life, and if discovered, require no treatment other than periodic observation. Typically, symptomatic meningiomas are treated with either radiosurgery or conventional surgery. Historical evidence of meningiomas has been found going back hundreds of years, with some successful surgeries for their removal beginning in the 1800s. ...
Results The mean age at presentation was 11 years (range: 6-17 years). There were six female patients and two male patients. 2/8 patients had associated neurofibromatosis type 2. Patients were followed up for 71-297 months (mean 156±70 months). 6/8 patients were observed through the course of their disease and 2/8 patients were treated with radiotherapy. 2/8 patients who were observed had minimal change in vision and did not experience tumour growth after long-term follow-up. ...
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Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
This morning CNN fed a headline: Sheryl Crow: Brain Tumor is a Bump in the Road. This concerned me, not only because Im a huge fan, but because in 2006, she began treatment for breast cancer at age 43. Singer-songwriter Sheryl Crow says she has a brain tumor, says the first line of the CNN story. I was concerned. It seemed liked shed been getting a little bit closer…to feeling fine.. Fortunately, the LATimes and People magazine got Crows story right. Their headlines, and text, emphasize the benign nature of Crows newly-diagnosed condition, a meningioma. Most meningiomas are benign, local expansions of the cells that line the brain and spinal cord. These growths occasionally cause neurological symptoms. Some patients have surgery to relieve or avoid complications of these non-malignant growths, but many dont need intervention ...
TY - JOUR. T1 - The evolving role of radiosurgery in the management of radiation-induced meningiomas. T2 - A review of current advances and future directions. AU - Mansouri, Alireza. AU - Badhiwala, Jetan. AU - Mansouri, Sheila. AU - Zadeh, Gelareh. N1 - Publisher Copyright: © 2014 Alireza Mansouri et al. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2014. Y1 - 2014. N2 - Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. ...
TY - JOUR. T1 - Predictors of recurrence in the management of chordoid meningioma. AU - Choy, Winward. AU - Ampie, Leonel. AU - Lamano, Jonathan B.. AU - Kesavabhotla, Kartik. AU - Mao, Qinwen. AU - Parsa, Andrew T.. AU - Bloch, Orin. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms chordoid AND meningioma was performed to identify all reports of pathologically confirmed intracranial CMs. A total of 221 patients were included, comprising 120 females and 101 males. Mean age, MIB-1/Ki67, and tumor size was 45.5 years, 4.3 % (range 0.1-26.6 %), and 4.1 cm ...
The International Agency for Research on Cancer (IARC) has published the results of the INTERPHONE combined analysis for glioma and meningioma and found overall no increased risk of brain cancer from mobile phone use.. In announcing the results for glioma and meningioma, Dr Christopher Wild, Director of the International Agency for Research on Cancer (IARC) said:. An increased risk of brain cancer is not established from the data from INTERPHONE. However, observations at the highest level of cumulative call time and the changing patterns of mobile phone use since the period studied by INTERPHONE, particularly in young people, mean that further investigation of mobile phone use and brain cancer risk is merited.. The INTERPHONE researchers conclude:. Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible ...
Doctors give unbiased, trusted information on the use of Gamma Knife Surgery for Meningioma: Dr. Bonuel on radiation necrosis after gamma knife surgery for meningioma: Stereotactic surgery is usually a minimally invasive procedure using x-ray and computers to locate a spot or lesion to perform a needle biopsy through a very small incision. Gamma knife is a non-invasive procedure to deliver very carefully a high dose of radiation therapy with specialized equipment to treat a lesion or tumor with no incision.
This multicentre case-control study of 1906 cases and 5565 controls provides no evidence of any association between occupational exposure to organic solvents and meningioma in the overall study population or in women or men separately. There were also no significant trends of increasing risk with either increasing cumulative exposure or duration of exposure. However, interpretation of these negative findings should take into account the strengths and limitations of the study.. While the INTEROCC study is the largest case-control study conducted to date investigating associations between occupational exposure to organic solvents and meningioma, the relatively low-exposure prevalence in the study population limited its power to identify significant associations and in particular after stratification by gender. Potential sources of selection and recall bias in the design and conduct of the INTERPHONE study on which this study was based have been addressed in detail elsewhere;28 ,36 however, these ...
abstractNote = {A 12 year-old girl was treated with prophylactic cranial irradiation for acute lymphoblastic leukaemia (ALL). At the age of 39, she was admitted to our hospital for status epilepticus. Computed tomography demonstrated two, enhancing bilateral sided intracranial tumors. After surgery, this patient presented meningiomas which histologically, were of the meningothelial type. The high cure rate in childhood ALL, attributable to aggressive chemotherapy and prophylactic cranial irradiation, is capable of inducing secondary brain tumor. Twelve cases of high-dose radiation-induced meningioma following ALL are also reviewed. (author ...
CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):59-62. Solitary fibrous tumor of the tentorium cerebelli. Case report. Pérez-Núñez A., Rivas J. J., Ricoy J. R., Miranda P., Arrese I., Lobato R. D., Ramos A.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):63-5. Spontaneous rupture of spinal dermoid cyst with disseminated lipid droplets in central canal and ventricles. Goyal A., Singh D., Singh A. K., Gupta V., Sinha S.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):67-70. Neurological deterioration after head trauma in patients with colloid cysts of the 3rd ventricle. Two case histories. Cultrera F., Parisi G., Platania N., Consoli V., Albanese V.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):71-73. Metastasis of breast carcinoma to intracranial meningioma. Baratelli G. M., Ciccaglioni B., Dainese E., Arnaboldi L.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 ...
PRIMARY OBJECTIVES:. I. To determine the efficacy of bevacizumab in patients with recurrent or progressive benign and atypical/malignant meningiomas, despite prior therapy, as measured by six-month progression-free survival.. SECONDARY OBJECTIVES:. I. To describe the response rate and overall-survival in this patient population.. II. To evaluate the safety profile of bevacizumab in patients with recurrent meningiomas.. III. To perform an exploratory study in patients with hemangioblastoma and hemangiopericytoma.. IV. To assess tissue for VEGF and VEGFR to correlate with response. An exploratory analysis of HER-2 will be performed.. OUTLINE:. Patients receive bevacizumab IV over 30-90 minutes every 2 weeks for 6 months. Patients may then receive bevacizumab IV every 3 weeks for up to 12 months. Treatment continues in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed every 3 months for 2 years. ...
A case of haemangiopericytic meningioma of the sacral canal in a 25 year old man, an uncommon tumour at a rare site, is described. The tumour was malignant and largely undifferentiated although there was light and electron microscopic evidence of dual differentiation in areas towards haemangiopericytoma and meningioma. The patient, with cauda equina syndrome, was treated by partial resection and post-operative radiotherapy and remains well 12 months after treatment.. ...
TY - JOUR. T1 - Meningiomas of the tuberculum and diaphragma sellae. AU - Ajlan, Abdulrazag M.. AU - Choudhri, Omar. AU - Hwang, Peter. AU - Harsh, Griffith. PY - 2015/2. Y1 - 2015/2. N2 - Introduction Although tuberculum sellae (TS) and diaphragma sellae (DS) meningiomas have different anatomical origins, they are frequently discussed as a single entity. Here we review the radiologic and intraoperative findings of TS and DS meningiomas and propose a radiologic classification. Methods We retrospectively reviewed 10 consecutive TS and DS meningiomas. Data regarding clinical presentation, preoperative imaging, and intraoperative findings were analyzed. Three sellar dimensions were measured on magnetic resonance imaging (MRI): the tuberculum-sellar floor interval (TSFI), the planum-tuberculum interval (PTI), and the total height. Results Three distinct anatomical patterns were recognized: exclusively tubercular meningiomas (type A) were accompanied by elongation of the TSFI and, more significantly, ...
There has been a lot of talk in the press lately about dental x-rays and their possible links to a specific brain tumor known as intracranial meningioma. The study that was covered extensively on national news was conducted by asking to two groups of people about their history of dental x-rays. One group had the […] ...
2The Second Affiliated Hospital of Xinjiang Medical University, Department of Neurosurgery, Urumqi, China DOI : 10.5137/1019-5149.JTN.8670-13.1 AIM: This study aimed to investigate the operative procedure for neuroendoscope-assisted microscopic resection of petroclival meningioma to improve prognosis.. MATERIAL and METHODS: Twelve patients with petroclival meningioma who had undergone neuroendoscope-assisted microscopic resection at the Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University were selected. In addition, 12 patients with petroclival meningioma who had undergone microscopic surgery were used as control. Clinical data from the 24 cases of petroclival meningioma were analyzed.. RESULTS: For the neuroendoscope-assisted group, six, five, and one cases were respectively subjected to total resection, subtotal resection, and most resection. For the microscopic surgery group, two, three, and seven cases were respectively subjected to total resection, subtotal ...
People who have had frequent dental X-rays may have an increased chance of developing a meningioma, one of the most commonly diagnosed brain tumors, according to a new study. Most meningiomas are non-malignant, but they can grow very large. Depending upon their location in the skull, they can also cause severe symptoms like memory loss, frequent headaches, vision and hearing loss and seizures. Ionizing radiation, such as X-rays, is the biggest risk factor for developing a meningioma.