TY - JOUR. T1 - Single-fraction radiosurgery of benign intracranial meningiomas. AU - Pollock, Bruce E.. AU - Stafford, Scott L.. AU - Link, Michael J.. AU - Brown, Paul D.. AU - Garces, Yolanda I.. AU - Foote, Robert L.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - BACKGROUND:: Stereotactic radiosurgery (SRS) of benign intracranial meningiomas is an accepted management option for well-selected patients. OBJECTIVE:: To analyze patients who had single-fraction SRS for benign intracranial meningiomas to determine factors associated with tumor control and neurologic complications. METHODS:: Retrospective review was performed of 416 patients (304 women/112 men) who had single-fraction SRS for imaging defined (n = 252) or confirmed World Health Organization grade I (n = 164) meningiomas from 1990 to 2008. Excluded were patients with radiation-induced tumors, multiple meningiomas, neurofibromatosis type 2, and previous or concurrent radiotherapy. The majority of tumors (n = 337; 81%) involved the cranial base ...
Introduction: Meningiomas are predominantly benign tumors, which arise from the arachnoids cap cells. The development mechanism is unknown but they may result from an adverse effect of cranial irradiation and trauma. Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. Materials and Methods: This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. The study included samples from intracranial meningioma patients ...
Extracranial meningiomas are classified according to Hoye et al. [4]. Primary extracranial meningioma and secondary extracranial meningioma can be classified according to the presence or absence of an intracranial meningioma. Primary extracranial meningiomas are composed of two types: a tumor originating from arachnoid cells remaining in the nerve sheaths and a tumor occurring ectopically without connection to the cranium. Secondary extracranial meningiomas are classified as intracranial tumors directly escaping from the cranium and extracranial meningioma that has metastasized from an intracranial meningioma [6]. According to this classification, our case is classified as an ectopic primary extracranial meningioma.. Intradural meningioma is known to be associated with radiation, virus, head trauma, smoking, nitrate, and high cholesterol levels, but the cause of primary extracranial meningioma is not yet clear. Possible hypotheses are as follows: (1) migration of arachnoid cells along the ...
meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Cases reported • Meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
A meningioma is a type of brain tumor thats said to be to second most common type of brain tumor occurring in humans today. A meningioma brain tumor primarily develops in the meninges, the thin layers of tissue surrounding the spinal cord and the brain. In most cases, these brain tumors can grow in size and spread, although its difficult to determine the tumors growth rate. Upon growth, these tumors put pressure on surrounding brain tissue.. Meningiomas can be classified into three grades, as set by the World Health Organization. Grade I meningiomas are classified as benign, Grade II meningiomas are identified as atypical, while Grade III meningiomas are considered anaplastic. Meningiomas are usually benign, but Grade III meningiomas are malignant. The average survival rate for Grade III meningiomas, without relapse, is currently at about three years.. There are some factors that contribute to the development of brain tumors in the meninges. Excessive exposure to ionizing radiation or x-rays ...
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state. Consistent with this observation, atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks. Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. Our results ...
This report presents magnetic resonance imaging (MRI) findings of a breast carcinoma metastasis in an intracranial meningioma with correlated pathological findings. MRI showed multiple foci of intense enhancement with hypointense surrounding areas. The described foci appeared to be metastatic disease from the patients known breast carcinoma. In addition, this is the first study reported in the literature to have investigated the expression of a possibly common carcinogenic molecule in breast carcinoma metastatic to a coexisting meningioma: overexpressed c-myc oncogene was found both in the breast carcinoma compartment and in the meningioma component of the tumor. ...
Coexistence of pituitary adenoma, intracranial meningioma and cerebral aneurysm has never been described. We report on a patient with GH-secreting pituitary macroadenoma associated with a right...
Twenty four meningiomas (17 benign and seven atypical were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost exclusively of the CD8 subtype, were also present in 70% of benign meningiomas and in all atypical meningiomas and were more abundant in the latter. B lymphocytes were present in minimal numbers in three atypical meningiomas and in one benign meningioma. CD4 positive T lymphocytes were present in small numbers in one benign meningioma and in moderate numbers in one atypical meningioma. HLA DR antigen expression on tumour cells was present in about 60% of both tumour groups. The numbers of macrophages and T and CD8 lymphocytes in meningiomas seem to be related to atypical histological features, and the presence of these cells raises questions about host immune response and the relation of this to prognosis.. ...
Intraventricular Malignant Meningioma - Malignant meningioma· Intraventricle· Frontal horn· Third ventricle· Surgical approach.J Korean Neurosurg Soc 34 : 379-381;KISEP380 J Korean Neurosurg Soc 34Intraventricular Malignant Meningiomaand was removed a piecemealfashion using biopsy forceps
TY - JOUR. T1 - Preoperative Embolization of Intracranial Meningiomas. AU - Yoshida, Kazunari. AU - Toya, Shigeo. AU - Takamiya, Yoshiaki. AU - Murakami, Hideki. AU - Kawase, Takeshi. AU - Shiga, Hayao. PY - 1985. Y1 - 1985. N2 - The method and results for preoperative embolization are described in 36 cases with intracranial meningiomas. Embolization materials were injccted through a transfemoral catheter, selectively placed in the external carotid artery. Chopped gelfoam served as embolization material in 29 patients and ivalon particles were used in 7 patients. In 19 out of 36 cases the feeding arteries arose only from the external carotid artery system and were completely occluded (complete embolization) except in 3 cases. The remaining 17 cases also had feeders of the tumor capsule or at the site of the insertion arising from the internal carotid artery system (partial embolization). Thirty-three cases were followed by computed tomography (CT) between embolization and operation. Contrast ...
TY - JOUR. T1 - Anatomic location is a risk factor for atypical and malignant meningiomas. AU - Kane, Ari J.. AU - Sughrue, Michael E.. AU - Rutkowski, Martin J.. AU - Shangari, Gopal. AU - Fang, Shanna. AU - McDermott, Michael W.. AU - Berger, Mitchel S.. AU - Parsa, Andrew T.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/3/15. Y1 - 2011/3/15. N2 - BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I meningiomas after surgery and/or external irradiation. As the utility of noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess the likelihood that a tumor is not benign before treatment initiation. Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location. METHODS: The authors reviewed 378 patients presenting at their institution from 2000 to 2007 with histologically ...
The aim of this work was to study the vascular endothelial growth factor A (VEGF-A) pathway and peritumoral brain edema (PTBE) through comparison of non-angiomatous and angiomatous meningiomas. Meningiomas are common intracranial tumors, which often have PTBE. VEGF-A is an integral part of PTBE formation and angiogenesis, and the capillary-rich angiomatous meningiomas are known for their PTBE. The VEGF-A receptor VEGFR-2 is responsible for the angiogenic effect of VEGF-A on endothelial cells, which is enhanced by the co-receptor neuropilin-1. Forty non-angiomatous, 22 angiomatous meningiomas, and 10 control tissue samples were collected for the study. Magnetic resonance images were available for 40 non-angiomatous and 10 angiomatous meningiomas. Tissue sections were immunostained for CD34, MIB-1, estrogen- and progesterone receptors. ELISA, chemiluminescence, and RT-qPCR were used for VEGF-A, VEGFR-2, and neuropilin-1 protein and mRNA quantification. Angiomatous meningiomas had larger PTBE (695 ...
A case of malignant meningioma which has grown rapidly after gross total removal and metastasized to thoracic spines after second operation is reported. We recommend that early spinal magnetic resonance image should be performed in patient with spinal symptoms and signs after the treatment of intracranial meningioma and intensive treatment combined with operation and radiosurgery should be performed for the reduction of growth rate in the recurred malignant meningoma. ...
Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients.. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and his team will determine the plasma exposure and brain accumulation of LEE011 following 5-day dosing in patients with recurrent atypical and malignant meningiomas; will evaluate select PD biomarkers corresponding to CDK4/6 inhibition, including Rb phosphorylation, cells in M-phase of cell cycle (PH3), and FoxM1 downregulation and explore the safety and efficacy of LEE011 in recurrent atypical and malignant meningioma with demonstrated pharmacokinetic and pharmacodynamic effects.. Dr. Sanai shares, What drives me forward is the opportunity to discover things that others in humankind have never seen, as we as find ...
Temporal bone meningioma can be considered as a part of the ectopic meningioma group. The known female preponderance of intracranial meningiomas is also seen in external auditory canal meningioma.4 Up to 20% of intracranial meningiomas may have extraneuraxial extension, 5,6,7,8. including the skull, scalp (all cutaneous sites), orbit, upper airway involvement (nasal cavity, paranasal sinuses, nasopharynx), soft tissues, and ear / temporal bone. However, when the scalp, orbit, sinonasal tract, oral cavity, and soft tissues are excluded, the incidence decreases to ,1% 6, 9, 10, 11. Ectopic or extracranial meningiomas are classified into 4 subgroups: direct extension from primary intracranial meningioma, extracranial growth from cranial nerve sheath arachnoidcells, extracranial extension from embryonic arachnoid rests without connection to the skull base or cranial nerves, and distant metastasis from intracranial tumors.3 Meningioma gains access to the temporal bone from 3 principal sites of ...
Introduction Forkhead Box M1 (FOXM1) and aryl hydrocarbon receptor (AHR) signaling pathway participate in meningioma development, but their correlation was inadequately studied. The study is aimed to uncover their functions and correlation in malignant meningioma. Material and methods...
Intracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles. Here, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors. We conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells
MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability ...
Meningiomas, which invade intracranial bone structures and the adjacent connective tissue, are frequently unresectable because of their aggressive and recalcitrant growth behavior. They have a high recurrence rate, and in approximately 10% of these tumors there is an increased risk of malignancy. Significant morbidity and mortality rates associated with recurrent meningiomas demand nonsurgical approaches. To date, adjuvant hormonal treatment has not proven beneficial. The anticancer drug hydroxyurea was therefore tested for its potential use in the treatment of meningiomas.. Early-passaged cell cultures were established from 20 different meningiomas. The addition of 5 X 10−4 and 10−3 M hydroxyurea over a period of 5 to 9 days resulted in a remarkable decrease in cell proliferation and even blocked tumor cell growth when compared with untreated cells. A significant arrest of meningioma cell growth in the S phase of the cell cycle was revealed on DNA flow cytometry.. Electron micrographs of ...
MENINGIOMA. Meningiomas are extra-axial tumours and represent the most common tumour of the meninges. They are a non-glial neoplasm that originates from the arachnoid cap cells of the meninges. They are typically benign with a low recurrence rate but rarely can be malignant.. Typical meningiomas appear as dural based masses isointense to grey matter on both T1 and T2 weighted imaging, and demonstrate vivid contrast enhancement on both MRI and CT. There are, however, many variants some of which can vary dramatically in their imaging appearance. Epidemiology. Meningiomas are more common in women, with a ratio of 2:1 intracranially and 4:1 in the spine. Atypical and malignant meningiomas are slightly more common in males. They are uncommon in patients before the age of 40 and should raise suspicion of neurofibromatosis type 2(NF2) when found in young patients.. Grading. Generally follows the WHO classification for CNS tumours:. ...
TY - JOUR. T1 - 18F-Choline PET/CT in Leptomeningeal Breast Cancer Metastases. AU - Cuppari, Lea. AU - Reccia, Pasquale. AU - Burei, Marta. AU - Cervino, Anna Rita. AU - Evangelista, Laura. PY - 2019/2. Y1 - 2019/2. N2 - We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights that F-choline PET would be used for the identification of leptomeningeal involvement in patients affected by breast cancer, as a support of MRI images.. AB - We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights ...
Meningiomas account for around 25% of primary brain tumours, and most often occur between the age of 40 and 70 years. They are more common in females. Atypical meningiomas are more aggressive than benign meningiomas, and account for around 5% of all meningiomas. Around 4% of meningiomas are malignant ...
Anaplastic meningiomas (also known as malignant meningiomas) are uncommon, accounting for only ~1% of all meningiomas 1. Along with rhabdoid meningioma and papillary meningioma are considered WHO grade III tumors and demonstrate aggressive local ...
TY - JOUR. T1 - Optic nerve seeding of atypical meningiomas presenting with subacute visual loss. T2 - 2 case reports with genetic characterization. AU - Kitamura, Yohei. AU - Akiyama, Takenori. AU - Sasaki, Hikaru. AU - Hayashi, Yuichiro. AU - Yoshida, Kazunari. PY - 2013/8. Y1 - 2013/8. N2 - Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical ...
Meningiomas are tumours of the membranes that cover the brain. Meningiomas are described as atypical when the tumor cells do not appear typical or normal. The standard treatment for patients with atypical meningioma is surgery to remove the tumour. Radiotherapy to kill any tumour cells left behind after surgery (post-operative radiotherapy) can increase the patient survival rate. The aim of this study is to find out whether a form of radiotherapy called carbon ion boost in combination with post-operative photon radiotherapy can improve the patient survival rate after 3 years ...
Authors reviewed 92 cases of intracranial meningiomas which confirmed by operation at the Department of Neurosurgery, Seoul National University Hospital from September 1957 to July 1982. 45 cases out of 50 cases that had performed computerized tomographic(CT) scans preoperatively were analyzed. The results were as following ; 1) Meningiomas constituted 12.4% of all intracranial tumors. There were 51 women and 41 men(55.4%/44.6%). The average age at the time of diagnosis was 41.2 years. 2) The initial symptoms were headache(50.0%), visual disturbance(14.1%), and seizure(8.7%) in the order. 3) The most common location was parasagittal-falcial, and followed by convexity, sphenoid ridge, tuberculum sellae tentorial and olfactory groove. 4) 61 cases(76%) out of 80 cases showed abnormal findings in the plain skull X-ray examinations. The preenhanced CT scans(45 cases) showed hyperdense lesion in 57.8%(26 cases), isodense lesion in 35.6%(16 cases), and hypodense lesion in 6.6%(3 cases). The incidence ...
TY - JOUR. T1 - A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas. AU - Coggins, William S.. AU - Pham, Nguyen K.. AU - Nguyen, Anthony V.. AU - Branch, Daniel W.. AU - Guillet, June Y.. AU - Korst, Genevieve. AU - Lall, Rishi R.. PY - 2019/12. Y1 - 2019/12. N2 - Objective: Atypical and anaplastic meningiomas, unlike their benign counterparts, are highly aggressive, locally destructive, and likely to recur after treatment. These diseases are difficult to definitively treat with traditional radiotherapy without injuring adjacent brain parenchyma. The physical properties of ion radiotherapy allows for treatment plans that avoid damaging critical neural structures. The objectives of this systematic review were to evaluate the use and efficacy of ion radiotherapy in the treatment of atypical and anaplastic meningiomas. Methods: We performed a systematic review of the literature by querying the PubMed and Ovid databases to identify and ...
Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, 10% are classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas. Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon. Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation. Here, we report that additional nullizygosity for p16Ink4a increases the frequency of meningioma and meningothelial proliferation in these mice without modifying the tumor grade. In addition, by using ...
TY - JOUR. T1 - Cognitive outcomes in meningioma patients undergoing surgery. T2 - Individual changes over time and predictors of late cognitive functioning. AU - Rijnen, S.. AU - Meskal, I.. AU - Bakker, M.. AU - Rutten, G.. AU - Gehring, K.. AU - Sitskoorn, M.. PY - 2018. Y1 - 2018. U2 - 10.1093/neuonc/noy139.387. DO - 10.1093/neuonc/noy139.387. M3 - Meeting Abstract. VL - 20. SP - iii317-iii317. JO - Neuro-Oncology. JF - Neuro-Oncology. SN - 1522-8517. IS - suppl 3. ER - ...
TY - THES. T1 - Cognitive functioning in meningioma patients. T2 - Insights in individual test performances and changes of performance after surgery. AU - Meskal, Ikram. PY - 2018. Y1 - 2018. M3 - Doctoral Thesis. SN - 978-94-6375-224-4. PB - Ridderprint. CY - s.l.. ER - ...
Meningioma is the most common extra-axial benign brain tumor. It is more common in females than males. Meningioma has both typical and atypical features. The diagnosis of typical meningioma is easier than atypical. Major differential diagnoses fo...
3Sakarya Training and Research Hospital, Department of Pathology, Sakarya, Turkey DOI : 10.5137/1019-5149.JTN.9907-13.1 With an incidence rate of 15-20%, meningiomas are one of the most common brain tumors among benign intracranial tumors. They are distributed as follows in intracranial localizations: parasagittal and falx (25%), convexity (18%), sphenoid wing (18%), parasellar (12%), posterior fossa (10%), intraventricular (2%), intraorbital (1%), and extracranial (1%). The most common extradural localizations are the paranasal sinuses, nasal cavity, skin, neck, glands, and intraosseous space. Intradiploic meningiomas are generally localized in the frontoparietal and orbital regions. Due to their low incidence and lack of adequate preoperative diagnostic testing, intradiploic meningiomas are generally mistaken for primary calvarial bone tumors and en plaque meningiomas. Our case was discussed here with literature findings since primary intradiploic meningioma is uncommon and poses diagnostic ...
Introduction. Meningiomas are extra-axial tumors,generally benign, originated by arachnoid cell degene-ration. They are more common in adults (40-60 years)and females. In 1973, Manelfe et al. first described preo-perative embolization of some meningiomas histotypes.Since then, the technique has remarkably improved, byusing micro-catheters and with the development ofmaterials used to perform the procedure, along withthe growing experience of neurosurgeons and neuro-radiologists. Several authors have shown that the pro-cedure reduces intraoperative bleeding. However, preo-perative embolization is still a matter of debate.Object. The objective of this study was to determinatethe benefits of preoperative embolization usingpolyvinyl alcohol (PVA) in selected patients, highlightingclinical indications to safely perform the technique.Materials and Methods. In the last 12 years, 50 patien-ts (13 males and 37 females, mean age 60.5) with adiagnosis of meningioma, underwent Digital Subtrac-tion ...
TY - JOUR. T1 - Metastatic meningioma in fine-needle aspiration (FNA) of the lung. T2 - Cytomorphologic finding. AU - Baisden, Blaire L.. AU - Hamper, Ulrike M.. AU - Ali, Syed Z.. PY - 1999/5. Y1 - 1999/5. N2 - Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellularity with large syncytial groups of monomorphic cells with epithelioid morphologic features, often in perivascular arrangements. Occasional intranuclear cytoplasmic inclusions as well as binucleated cells with wispy cytoplasmic extensions were also noted. Immunoperoxidase studies showed focal positivity for epithelial membrane antigen. The differential diagnosis includes primary or metastatic adenocarcinoma, malignant mesothelioma, and melanoma.. AB - Pulmonary metastasis ...
Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013 Aug;68[8]:837-44. http://dx.doi.org/10.1016/j.crad.2013.03.007 PMid:23623578 Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. 2013;13(4):337. http://dx.doi.org/10.1007/s11910-013-0337-4 PMid:23463172 Osborn AG, Salzman KL, Barkovich AJ. Meningioma and atypical and malignant meningioma. In: Osborn AG, editor. Diagnostic imaging: brain. 2nd ed. Salt lake city: Lippincott Williams & Wilkins/Amirys, 2009: p. 72-81. de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J Clin Neurosci. 2009;16:1246 9. http://dx.doi.org/10.1016/j.jocn.2008.11.017 PMid:19560362 Goncalves AM, Page P, Domigo V, Meder JF, Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol. 2010;31:1504 5. http://dx.doi.org/10.3174/ajnr.A1978 PMid:20053802 Shimizu J, Matsumoto M, Yamazaki ...
2Hacettepe Üniversitesi Tıp Fakültesi Beyin Cerrahisi Anabilim Dalı, Ankara Meningiomas represent approximately 13-26% of primary intracranial tumours. Many small meningiomas have no symptoms during life and may be found incidentally at autopsy. Such incidental meningiomas are detected more frequently in recent years because of the advent of CT and MRI. Malignant (anaplastic) meningiomas are less common lesions, accounting for 1-2.8% of meningiomas. Recently, clear cell and chordoid meningiomas have been classified as WHO Grade II and rhabdoid and papillary meningiomas classified as WHO Grade III tumors without pathological criteria for malignancy. Here we report a rare case of rhabdoid meningioma in a 31 year-old man. Using the presented case we discuss the prognostic significance of recognition of a rhabdoid meningioma in light of the literature. Anahtar Kelimeler : Meningioma, rhabdoid meningioma, prognostic significance ...
Background: Meningioma is one of the primary brain tumors that most often occurs at the age of 60-70 years, originating from arachnoid cap cells. FGF-2 as a growth factor is a potent stimulator of endothelial proliferation which is very important in the process of angiogenesis. FGF-2 levels in meningiomas have been assessed using the ELISA and qrPCR methods in many previous studies using blood serum in malignant cases with normal brain tissue as control. This study used tissue samples of meningioma tumors in which most cases of meningioma are benign. Objective: To assess the association between immunohistochemical expressions of FGF-2 and histopathology grade among meningioma patients. Material and Method: Formalin-fixed paraffin-embedded tissue blocks of 32 meningioma patients were immunohistochemically studied for FGF-2 expression. The basic characteristics of the samples were obtained through medical records or pathology archieves. The association between FGF-2 expression and grade were ...
Intracranial aneurysms and meningiomas are rarely associated. We review the concerned literature, and report a patient operated for an anterior communicating artery aneursym, found at surgery to harbour a small ipsilateral meningioma at the lesser wing of the sphenoid. We also review the proposed causes of such an association. Factors related to the meningioma are usually thought to be behind the development of associated aneurysms. Considering the size of the meningioma in our patient, we believe that both lesions form concomitantly under the effect of certain genetic or systemic factors, influenced by local circulatory changes. These factors are to be determined with more basic science research ...
Answer: Meningioma, WHO grade I. Histology: The lesion is comprised of bland spindled cells arranged in clusters and whorls with focal intranuclear pseudoinclusions and frequent psammoma bodies. No mitotic figures are identified. No nuclear pleomorphism or necrosis is present. No brain invasion is identified.. Discussion: Meningiomas are common brain tumor arising from the dura covering the brain, and they are the most common benign brain tumor. They are more common in women and are usually solitary, but may be multiple, particularly when associated with neurofibromatosis type 2 (NF2), which is a defect in the NF2 gene encoding merlin on chromosome 22. Up to 60% of isolated or sporadic meningiomas also display somatic mutations in the NF2 gene (1). By immunohistochemistry, meningiomas are positive for progesterone receptor (PR) and EMA, which can be used in difficult cases to support a meningothelial origin. The majority of meningiomas (90%) are WHO grade I. Certain histologic variants are ...
Professor Richard Houlston from The Institute of Cancer Research led the major international collaboration comparing the DNA of 1,633 meningioma patients and 2,464 healthy controls, using a technique known as a genome-wide association study.. Relatives of people with meningiomas are three times more likely to develop the disease but little is known about what increases their risk. A small proportion of meningiomas are linked to four rare genetic diseases called neurofibromatiosis type-2, Coden, Werner and Gorlin symdromes.. Professor Houlston said: We knew that people with certain rare inherited diseases are more likely to develop meningiomas. Although these inherited diseases significantly increase the chance of getting this type of brain cancer, they are so rare that they account for a very small proportion of the increased risk among relatives of people with meningiomas. Our study begins to shed light on the biggest part of the inherited risk.. The genetic region weve found is very closely ...
Meningioma Mommas is asking for help to fund an exciting new project by the team of University of Colorado researchers we have previously funded. Please help us help the researchers find better treatment options for meningioma patients by donating here or via our own Donate page.. From the researchers:. PROJECT SUMMARY. Meningiomas are a common brain tumor, considered to be the most prevalent primary brain tumor in the central nervous system. In spite of their burden, no FDA approved pharmacotherapies exist for the treatment of these tumors. Through our work with Meningioma Mommas, we have created a high throughput drug screen that allows us to directly measure the sensitivity of individual tumors to hundreds of FDA approved compounds. This approach has identified several possible treatments that have the ability to treat meningiomas broadly by targeting epigenetic processes. Many of the drugs in this class can cross the blood brain barrier making these ideal candidates for further studies. ...
see Venous infarction. Venous air embolism (VAE) during an elective craniotomy for parasagittal meningioma resection. The surgery was done in the supine position with slightly elevated head position. VAE was provisionally diagnosed by sudden decreased in the end tidal carbon dioxide pressure from 34 to 18 mmHg, followed by marked hypotension and atrial fibrillation. Prompt central venous blood aspiration, aggressive resuscitation and inotropic support managed to stabilize the patient. Post operatively, he was admitted in neuro intensive care unit and made a good recovery without serious complications 15).. Intraoperative fatal pulmonary embolism 16).. Paraparesis can occur as a primary presentation of brain pathology at the motor strip along the parasagittal region. It could also occur as a neurological complication especially following resection of parasagittal meningioma with infiltration of the superior sagittal sinus (SSS). We report a case of a complete paraparesis immediately following ...
Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and…. ...
BACKGROUND: Radiosurgery is the main alternative to microsurgical resection for benign meningiomas. OBJECTIVE: To assess the long-term efficacy and safety of radiosurgery for meningiomas with respect to tumour growth and prevention of associated neurological deterioration. Medium to long-term outcomes have been widely reported, but no large multicentre series with long-term follow-up have been published. METHODS: […]. Read more of this post. Add a comment to this post. ...
Meningiomas are uncommonly associated with cysts and account for 1.6-10% of intracranial meningiomas 1) 2) 3) Those with more numerous smaller peripheral cysts are more frequent (8-23% of cases). They are over-represented in male patients and the paediatric population Clinical presentation Patients present clinically in the same way as patients with non-cystic meningiomas, with either symptoms related to increased intracranial pressure (ICP), focal neurology, or seizures. Pathology Various mechanisms have been proposed, and probably more than one is applicable depending on the location of the cysts: degeneration or necrosis direct secretion by meningioma reactive changes (peripheral arachnoid cysts) Classification Nauta et al. divided cystic meningiomas into four subtypes according to the location of the cyst with respect to the brain and meningioma type 1: intratumoral cyst(s), located centrally within the meningioma type 2: intratumoral cyst(s), situated peripherally within the meningioma but ...
TY - JOUR. T1 - Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis. T2 - case report. AU - Pozzati, Eugenio. AU - Zucchelli, Mino. AU - Schiavina, Mario. AU - Contini, Paola. AU - Foschini, Maria Pia. PY - 2007/12. Y1 - 2007/12. N2 - Background: Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. Case Description: We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. Conclusions: This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.. AB - Background: ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates from the arachnoid (not the dura), the tissue covering the brain and spinal cord lying deep to the dura. Meningiomas are much more common in females, and are more common after 50 years of age. Of all cranial meningiomas, about 20% of them are in the sphenoid wing. In some cases, deletions involving chromosome 22 are involved. Sphenoid wing meningiomas are diagnosed by the combination of suggestive symptoms from the history and physical and neuroimaging by magnetic resonance imaging (MRI) or computer averaged tomography (CT). Tumors growing in the inner wing (clinoidal) most often cause direct damage to the optic nerve leading especially to a decrease in visual acuity, progressive loss of color vision, defects in the field of vision (especially cecocentral), and an afferent pupillary defect. If the tumor continues to grow and push on the optic nerve, all vision will be ...
Management of Recurrent Skull Base Meningiomas Keywords: anaplastic, atypical, chemotherapy, endoscopic surgery, meningioma, microsurgery, minimally-invasive, radiosurgery, recurrence, skull base Sheri K. Palejwala, Garni Barkhoudarian, Walavan Sivakumar, Daniel F. Kelly Abstract Skull base meningiomas, due to their frequent investment or encasement of critical neurovascular structures, are challenging to resect in their entirety, both with initial resection…
Detail záznamu - 1H magnetic resonance spectroscopy study of different histological types of human meningiomas in vitro - Detailné zobrazenie záznamu - Slovenská lekárska knižnica
Detection of TP53 gene mutation in human meningiomas: A study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples ...
According to a study published online April 10, 2012 in the journal Cancer, researchers examined answers to a health survey from a group of 1433 meningioma patients and compared them to answers from a control group of 1350 people without these tumors. The meningioma group was twice as likely as the control group to report ever having had a bitewing exam, the meningioma group also was more likely to report having had a panorex exam at a young age (under 10 years old) or on a yearly or more frequent basis. The panorex exam is taken outside the mouth and shows all of the teeth in one film ...
TY - JOUR. T1 - The evolving role of radiosurgery in the management of radiation-induced meningiomas. T2 - A review of current advances and future directions. AU - Mansouri, Alireza. AU - Badhiwala, Jetan. AU - Mansouri, Sheila. AU - Zadeh, Gelareh. N1 - Publisher Copyright: © 2014 Alireza Mansouri et al. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2014. Y1 - 2014. N2 - Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. ...
PRIMARY OBJECTIVES:. I. To determine the efficacy of bevacizumab in patients with recurrent or progressive benign and atypical/malignant meningiomas, despite prior therapy, as measured by six-month progression-free survival.. SECONDARY OBJECTIVES:. I. To describe the response rate and overall-survival in this patient population.. II. To evaluate the safety profile of bevacizumab in patients with recurrent meningiomas.. III. To perform an exploratory study in patients with hemangioblastoma and hemangiopericytoma.. IV. To assess tissue for VEGF and VEGFR to correlate with response. An exploratory analysis of HER-2 will be performed.. OUTLINE:. Patients receive bevacizumab IV over 30-90 minutes every 2 weeks for 6 months. Patients may then receive bevacizumab IV every 3 weeks for up to 12 months. Treatment continues in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed every 3 months for 2 years. ...
MORALES, F. et al. Skull base meningiomas: a predictive system to know the extent of their surgical resection and patient outcome. Neurocirugía [online]. 2005, vol.16, n.6, pp.477-485. ISSN 1130-1473.. Objective. The aim of this study was to build a preoperative predictive system which could pro-vide reliable information about: 1° which skull base meningiomas can be total or partially removed, and 2° their surgical outcome. Method. Patient histories and imaging data were reviewed retrospectively from 85 consecutive skull base meningiomas patients who underwent surgery from 1990 and 2002. From the preoperative data, nine variables were selected for conventional statistical analysis as regards their relationship with: 1° total vs partial tumor resection and 2° with patients outcome according to the degree of tumour removal. Results. From the nine variables analysed only two had a statistical association with the type of tumour resection performed (total vs partial) and the patient outcome: 1) ...
TY - JOUR. T1 - Skull base meningiomas. AU - Couldwell, William T.. AU - Heros, Roberto. AU - Dolenc, Vinko. PY - 2011/5. Y1 - 2011/5. UR - http://www.scopus.com/inward/record.url?scp=84858619086&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84858619086&partnerID=8YFLogxK. U2 - 10.3171/2011.3.FOCUS1185. DO - 10.3171/2011.3.FOCUS1185. M3 - Editorial. C2 - 21529181. AN - SCOPUS:84858619086. VL - 30. JO - Neurosurgical Focus. JF - Neurosurgical Focus. SN - 1092-0684. IS - 5. ER - ...
TY - JOUR. T1 - Meningiomas of the tuberculum and diaphragma sellae. AU - Ajlan, Abdulrazag M.. AU - Choudhri, Omar. AU - Hwang, Peter. AU - Harsh, Griffith. PY - 2015/2. Y1 - 2015/2. N2 - Introduction Although tuberculum sellae (TS) and diaphragma sellae (DS) meningiomas have different anatomical origins, they are frequently discussed as a single entity. Here we review the radiologic and intraoperative findings of TS and DS meningiomas and propose a radiologic classification. Methods We retrospectively reviewed 10 consecutive TS and DS meningiomas. Data regarding clinical presentation, preoperative imaging, and intraoperative findings were analyzed. Three sellar dimensions were measured on magnetic resonance imaging (MRI): the tuberculum-sellar floor interval (TSFI), the planum-tuberculum interval (PTI), and the total height. Results Three distinct anatomical patterns were recognized: exclusively tubercular meningiomas (type A) were accompanied by elongation of the TSFI and, more significantly, ...
This study aims to evaluate quantitatively the mechanical properties of meningiomas and their correlation with the qualitative surgeons assessment of consistency, as well as comparing the capability to predict tumor consistency of fractional anisotropy values calculated from the diffusion tensor imaging and T1/T2 signal intensities. Sixteen patients with the diagnosis of intracranial meningioma were included. Fractional anisotropy values were calculated and T1/T2 assessment was performed. The qualitative assessment of the tumor consistency intraoperatively was determined by a neurosurgeon and quantitative assessment was obtained with the Warner-Bratzler mechanical test. Surgeons qualitative assessment was concordant with the cutting force obtained from the mechanical tests (P = 0.046). There was a high correlation between tumor consistency reported by the surgeon and T1/T2 assessment (0.622/P = 0.01) and a moderate correlation with cutting force (0.532/P = 0.034) and elasticity (0.49
Secretory meningioma is a distinct subtype of meningioma. We describe the cytologic features of a secretory meningioma on squash preparations, in comparision with other cytologic mimickers. A 54-year-old woman presented with hearing loss, vertigo, tinnitus, and headache for seven years. A brain MRI study revealed a 4.5 cm sized mass in the cerebellopontine angle, which showed homogenous signal intensity in T2-weighted image. The intraoperative squash smear showed some well-defined, thin rimmed intracytoplasmic inclusions, containing a finely granular eosinophilic core among less cohesive meningiomatous cells. Histologic sections revealed a meningothelial meningioma with scattered inclusions, with periodic acid-Schiff, carcinoembryonic antigen, and cytokeratin positivity. Identification of characteristic intracytoplasmic inclusions is helpful for diagnosing secretory meningiomas. On squash preparations, differential diagnoses included tumors with inclusions or cytoplasmic vacuolizations, such as ...
Primary extradural meningiomas are rare, accounting for less than 2% of all meningiomas; most cases involve the skull. A review of 169 cases was published by Lang et al.2 Only 3 cases of primary meningioma involving the mandible have been reported so far. The first case was by Landini and Kitano in 19923; another 2 cases were by Jones and Freedman in 2001.4 All patients, including ours, were women, and the radiographic presentation was a lytic lesion. Three cases of extracranial meningioma of the maxilla have been reported, excluding cases within the paranasal sinuses. A male patient presented with an oral lesion and a multilocular radiolucency on a periapical x-ray film.5 In 2 female patients, dental x-ray demonstrated a mixed radiolucent-radiopaque mass6 with ill-defined margins in 1 patient.7. To our knowledge, the appearance of mandibular meningioma in CT and MR imaging has not been previously reported.. The lesion in our patient appeared as a cystic lesion of the mandibular body on ...
TY - JOUR. T1 - Leptomeningeal carcinomatosis originating from advanced gastric cancer--a report of three cases and review of the literatures.. AU - Kusumoto, Tetsuya. AU - Kimura, Yasue. AU - Sugiyama, Masahiko. AU - Ohta, Mitsuhiko. AU - Tsutsumi, Norifumi. AU - Sakaguchi, Yoshihisa. AU - Ikejiri, Koji. AU - Oki, Eiji. AU - Saeki, Hiroshi. AU - Morita, Masaru. AU - Ikeda, Tetsuo. AU - Furuta, Toshiya. AU - Maehara, Yoshihiko. N1 - Copyright: Copyright 2014 Medline is the source for the citation and abstract of this record.. PY - 2013/11. Y1 - 2013/11. N2 - Leptomeningeal carcinomatosis (LMC) is a rare complication of gastric cancer. Case 1. A 57-year-old female was diagnosed with gastric cancer and underwent distal gastrectomy with D2 lymph node dissection. Two years later, the patient suffered from para-aortic lymph node metastases and provided chemotherapy. During the chemotherapy, the patient emergently visited our hospital with chief complaints of a severe headache and dizziness. The above ...
2Çukurova Üniversitesi Tıp Fakültesi Nöroşirürji, Adana, Türkiye Meningioma constitutes 14% to 20% of intracranial neoplasms and only 1 % are extradural. Extradural tissue includes the skin, the neck, the paranasal sinuses, the nasal cavities and the diploe of the cranial bones. The intra osseous tissue refers to the diploe of the cranial bones. Primary intraosseous meningiomas are seldom correctly diagnosed preoperatively and are usually mistaken for primary bone tumors and hyperosteotic en plaque meningiomas. Primary intra osseous meningioma is a rare entity, but the diagnostic criteria are not yet well defined. A case of primary intraosseous meningioma is reported here and the related literature is reviewed. Anahtar Kelimeler : Hyperostosis, intra osseous meningioma, calvarium ...
Similar to tumorigenesis in other tissues, development of meningiomas is likely to result from complex interactions between genes and environment. The etiological role of environmental factors in meningioma development has been suggested for ionizing radiation, diet, smoking, head trauma, and occupational exposures to carcinogenic substances. Of these factors, the evidence is convincing only for an association between ionizing radiation and meningiomas. Elevated risk of meningioma development was shown in studies involving patients who received a low-dose radiation therapy for childhood tinea capitis. Meningiomas were also found to occur years after any type of therapeutic cranial irradiation. Moreover, an increased incidence of meningiomas has been recently reported in survivors of atomic bomb explosions. Radiation-induced meningiomas are often aggressive or malignant. They are also. Was this article helpful?. ...
The resonance Raman (RR) spectra of six types of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro. Forty-three RR spectra from seven subjects are investigated. The spectral peaks from malignant meningioma, stage III (cancer), benign meningioma (benign), normal meningeal tissues (normal), glioblastoma multiforme grade IV (cancer), acoustic neuroma (benign), and pituitary adenoma (benign) are analyzed. Using a 532-nm excitation, the resonance-enhanced peak at 1548 cm−1 (amide II) is observed in all of the tissue specimens, but is not observed in the spectra collected using the nonresonance Raman system. An increase in the intensity ratio of 1587 to 1605 cm−1 is observed in the RR spectra collected from meningeal cancer tissue as compared with the spectra collected from the benign and normal meningeal tissue. The peak around 1732 cm−1 attributed to fatty acids (lipids) are diminished in the spectra collected from the meningeal cancer tumors ...
TY - JOUR. T1 - Fatal hemorrhagic infarction of posterior fossa meningioma during cardiopulmonary bypass. AU - Sun, Hai. AU - Ross, Donald (Don). PY - 2012/2. Y1 - 2012/2. N2 - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a suprasellar meningioma, hemiparesis after mitral valve replacement with recovery after resection, and non-fatal hemorrhage into a posterior fossa meningioma. The largest report of 16 patients with known meningiomas over 11 years suggested a benign course, with no new neurologic symptoms and no required resection of a meningioma over an average follow-up of 31 months. In 2 cases we report a presumed posterior fossa meningioma led to fatal outcome after cardiac surgery performed on bypass. Possible causes and future considerations are discussed.. AB - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a ...
Primary intraosseous meningiomas are uncommon. The osteolytic variants of these tumors are even rarer. When one reviews a bony skull lesion, the differential diagnosis is very wide and includes both malignant and benign diseases. In case of primary skull meningioma, correct diagnosis and total resection of the lesion ensures curative therapy. Presented is a case of osteolytic skull lesion not invading the dura that was proved to be a fibrillary meningioma with regions of syncitial pattern.
TY - JOUR. T1 - A phase II trial of PTK787/ZK 222584 in recurrent or progressive radiation and surgery refractory meningiomas. AU - Raizer, Jeffrey J.. AU - Grimm, Sean A.. AU - Rademaker, Alfred. AU - Chandler, James P.. AU - Muro, Kenji. AU - Helenowski, Irene. AU - Rice, Laurie. AU - McCarthy, Katie. AU - Johnston, Sandra K.. AU - Mrugala, Maciej M.. AU - Chamberlain, Marc. N1 - Funding Information: Acknowledgments This trial was supported by a research grant from Novartis.. PY - 2014/3. Y1 - 2014/3. N2 - When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibitor PTK787/ZK 222584 (PTK787) at a dose of 500 mg twice a day. Each treatment cycle was 4 weeks with MRI done every 8 weeks. Twenty-five patients (14 men; 11 women) with a median ...
Sphenoid wing meningiomas are slow growing tumors that originate from outer arachnoid meningeal epithelial cells. They are the most common tumor of the intracranial space to spread to the orbit.[1][2]
This study was performed to determine the clinical significance of diffuse dural enhancement (DDE) detected by magnetic resonance (MR) imaging and to typify enhancing patterns related to inflammatory or metastatic causes. The authors retrospectively evaluated the clinical, imaging, and laboratory characteristics of 20 consecutive patients with DDE. Those with DDE and an underlying neoplastic disease (13 patients) were compared to 11 consecutive patients with cytological evidence of neoplastic leptomeningeal metastasis evaluated by MR imaging. The DDE was often associated with an underlying malignancy (13 (65%) of 20 patients) but it coexisted with leptomeningeal metastasis in only one patient. Skull metastases were evident in 10 (77%) of 13 patients and cranial nerve palsies in six (46%) of 13. Other causes of DDE were related to cerebrospinal fluid (CSF) leak or shunting (five (25%) of 20), with or without symptoms of intracranial hypotension, and to dural sinus thrombosis and pachymeningitis. Dural
There has been a lot of talk in the press lately about dental x-rays and their possible links to a specific brain tumor known as intracranial meningioma. The study that was covered extensively on national news was conducted by asking to two groups of people about their history of dental x-rays. One group had the […] ...
Definition of meningotheliomatous meningioma. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular markers for medulloblastomas, their expression in meningioma has not been addressed to date. We examined the mRNA and protein expression of human ZIC1, ZIC2, ZIC3, ZIC4 and ZIC5 genes in meningiomas in comparison to other brain tumors, using RT-PCR, analysis of published microarray data, and immunostaining. ZIC1, ZIC2 and ZIC5 transcript levels in meningiomas were higher than those in whole brain or normal dura mater, whereas all five ZIC genes were abundantly expressed in medulloblastomas. The expression level of ZIC1 in public microarray data was greater in meningiomas classified as World Health Organization Grade II (atypical) than those classified as Grade I (benign). Immunoscreening using anti-ZIC antibodies revealed that 23 out of 23 meningioma cases were ZIC1/2/3/5-immunopositive. By
Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular markers for medulloblastomas, their expression in meningioma has not been addressed to date. We examined the mRNA and protein expression of human ZIC1, ZIC2, ZIC3, ZIC4 and ZIC5 genes in meningiomas in comparison to other brain tumors, using RT-PCR, analysis of published microarray data, and immunostaining. ZIC1, ZIC2 and ZIC5 transcript levels in meningiomas were higher than those in whole brain or normal dura mater, whereas all five ZIC genes were abundantly expressed in medulloblastomas. The expression level of ZIC1 in public microarray data was greater in meningiomas classified as World Health Organization Grade II (atypical) than those classified as Grade I (benign). Immunoscreening using anti-ZIC antibodies revealed that 23 out of 23 meningioma cases were ZIC1/2/3/5-immunopositive. By
Thirteen meningiomas of varying light microscopic features were studied immunohistologically using a panel of monoclonal antibodies directed against epithelial, mesenchymal, and neural components. All 13 meningiomas showed expression of epithelial membrane antigen, vimentin, and S100 protein, as did normal meninges. Five of the 13 meningiomas also showed focal expression of cytokeratins, with double labelling showing expression of cytokeratins and vimentin by different cells. The cytokeratin expression was especially noticeable in cells surrounding the hyaline bodies of meningiomas. These results provide further evidence that meningiomas have features of both mesenchymal and epithelial tissues.. ...
Dr. Long-Sheng Changs research is officially underway. Meningioma Mommas donated $10,000 to fund his project, Evaluation of Novel Targeted Therapies for Both NF2-Associated and Sporadic Meningiomas. The ultimate goal for Dr. Chang and his team at Ohio State University is to develop a medical therapy that effectively eradicates both NF2-associated and sporadic meningiomas. Meningioma Mommas is fortunate to have a compassionate individual on our side.. Dr. Chang writes, One thing I will never forget is how many tumors and surgeries these patients can have and that benign tumors can have life-altering effects. At national conferences and local meetings, I am amazed by their dedication to support research to find a cure for this debilitating disease in spite of their long-term suffering. This is exactly what I want to do-find a medical therapy to eradicate vestibular schwannomas and meningiomas. To achieve this goal, we have been studying the NF2 tumor suppressor gene, the disease-causing ...
Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
This morning CNN fed a headline: Sheryl Crow: Brain Tumor is a Bump in the Road. This concerned me, not only because Im a huge fan, but because in 2006, she began treatment for breast cancer at age 43. Singer-songwriter Sheryl Crow says she has a brain tumor, says the first line of the CNN story. I was concerned. It seemed liked shed been getting a little bit closer…to feeling fine.. Fortunately, the LATimes and People magazine got Crows story right. Their headlines, and text, emphasize the benign nature of Crows newly-diagnosed condition, a meningioma. Most meningiomas are benign, local expansions of the cells that line the brain and spinal cord. These growths occasionally cause neurological symptoms. Some patients have surgery to relieve or avoid complications of these non-malignant growths, but many dont need intervention ...
Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding-non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem-of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review. We hypothesized that the restricted diffusion along the anterior brainstem was caused by malignant cells concentrating in the cistern around the brainstem and infiltrating into the circumferential perforating arteries along the anterior brainstem surface, which then resulted in microinfarctions.
Photo essay at La Louviere clinic, France. Neurosurgery. Ablation of a cerebral tumor (here an agressive meningioma) assisted by a neuronavigation. The neuronavigation, the same way as a GPS, permits from a pre-established MRI, to locate in the space the position of patient in the surgery room. The aquisition of targeting data for the craniotomy is then facilitated. After the aperture of the cranial box, the neurosurgeon starts by removing the part of the meninges invested by the meningioma then remove the tumor that compresses the brain. The meningioma has not affected the cortical part, only a few arteries and veins have been « requisitionned » by the tumor here is why its designation of « agressive meningioma ». This sort of tumor appear more frequently on the menopaused patient because of the hormonal disturbances. Here, plasty dura mater and sutures. - Stock Image C004/0790
Hollywood stunt woman Jill Brown received an incidental diagnosis of a benign convexity meningioma brain tumor after a stunt went awry. Watch as she recounts what led her to travel across the country to have her surgery performed at The Johns Hopkins Hospital in Baltimore. Learn more at http://www.hopkinsmedicine.org/HowFar. For appointments call 1-888-899-9420 ...
People who have had frequent dental X-rays may have an increased chance of developing a meningioma, one of the most commonly diagnosed brain tumors, according to a new study. Most meningiomas are non-malignant, but they can grow very large. Depending upon their location in the skull, they can also cause severe symptoms like memory loss, frequent headaches, vision and hearing loss and seizures. Ionizing radiation, such as X-rays, is the biggest risk factor for developing a meningioma.
Patients with gynecologic malignancies may develop metastases throughout the neuraxis. Cervix-related carcinomatous meningitis is a distinctly unusual clinical event with only two previous cases reported in the English medical literature. We review c
Atypical teratoid/rhabdoid tumors (AT/RT) are rare malignant neoplasms that mainly affect infants and young children, and are typically located in the cerebellar hemispheres. These tumors are histologically characterized by varying proportions of rhabdoid cells, and nuclear INI1 immunonegativity. Here, we report a case of a 15-year-old male with primary diffuse leptomeningeal AT/RT. The patient had symptoms similar to those of meningitis. Magnetic resonance imaging revealed leptomeningeal thickening. Cytological examination using cerebrospinal fluid was repeatedly performed and revealed rhabdoid cells with loss of INI1 reactivity, and shortly after, the diagnosis of AT/RT was confirmed by tissue biopsy ...
We describe a case of a 67-year-old man with known chronic obstructive pulmonary disease, type 2 diabetes mellitus, hypertension, osteoarthritis, previous history of excess alcohol intake, and oesophagectomy 3 years earlier for T3N0 adenocarcinoma, referred by his general practitioner with confusion, weight loss and several recent falls. CT of the chest, abdomen and pelvis revealed a right middle-lobe pulmonary embolism, while CT of the head revealed a communicating hydrocephalus. Lumbar puncture was performed, and empirical treatment for tuberculous and fungal meningitis was commenced. Unfortunately, he suffered a rapid neurological deterioration with markedly elevated cerebrospinal fluid (CSF) pressures, leading to an external ventricular drain. Cytological analysis of a CSF sample revealed a cellular infiltrate consistent with leptomeningeal carcinomatosis (adenocarcinoma), with the previous oesophageal malignancy the likely primary. He passed away 17 days after hospital admission. Prolonged ...
Aim: The aim of this study was to assess both the epidermal growth factor receptor (EGFR) protein expression by immunohistochemistry and the EGFR gene amplification by fluorescence in situ hybridization in meningiomas of different grade, in order to evaluate their possible role in the development of the disease. EGFR protein belongs to the family of tyrosine kinase growth factor receptors, which also includes HER2, HER3 and HER4. Elevated expression or activity of EGFR has been reported in several cancers, including brain tumours. EGFR activation can enhance the malignant potential of epithelial tissues ...
Penfield was the first to describe ischaemic changes in meningiomas.1 He thought that meningiomas have a peripheral blood supply and that the centre of the tumour is a watershed area which becomes increasingly oligaemic as the tumour grows. Pullicino et al reported a case of central infarction occurring within a frontal meningioma after a short period of hypotension during cardiac arrest.2 Necrosis in a meningioma after systemic chemotherapy has also been reported3; the patient had a rectal carcinoma and an asymptomatic large vertex meningioma. He presented 2 weeks after the start of chemotherapy for his rectal tumour with neurological deterioration necessitating surgical removal of his brain tumour. A large area of central necrosis was seen on imaging and pathological examination of the tumour disclosed a typical syncytial meningioma with large areas of necrosis of at least 1 week of age.. Our patient presented with severe headache on the 3rd day after extensive cosmetic surgery that ...
TY - JOUR. T1 - Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. AU - Parada, Carolina Angelica. AU - Osbun, Joshua. AU - Kaur, Sumanpreet. AU - Yakkioui, Youssef. AU - Shi, Min. AU - Pan, Catherine. AU - Busald, Tina. AU - Karasozen, Yigit. AU - Gonzalez-Cuyar, Luis Francisco. AU - Rostomily, Robert. AU - Zhang, Jing. AU - Ferreira, Manuel. PY - 2018/12/1. Y1 - 2018/12/1. N2 - There is a need to better understand meningioma oncogenesis for biomarker discovery and development of targeted therapies. Histological or genetic criteria do not accurately predict aggressiveness. Post-translational studies in meningioma progression are lacking. In the present work, we introduce a combination of mass spectrometry-based phosphoproteomics and peptide array kinomics to profile atypical and anaplastic (high-grade) meningiomas. In the discovery set of fresh-frozen tissue specimens (14), the A-kinase anchor protein ...
TY - JOUR. T1 - A primary meningioma of the lumbar spine with neck metastasis. AU - Sung, Chih-Wei. AU - Hsieh, Kevin Li-Chun. AU - Kuo, Yi-Jie. PY - 2019. Y1 - 2019. N2 - Context: Approximately 25% of all primary spinal cord tumors are meningiomas, and 80% of these tumors occur in the thoracic region. Few meningiomas of the lumbar spine have been presented. Extracranial metastasis of meningioma occurs extremely rare, only in about 0.1% of meningiomas. Even metastasis, the sites are seldom seen in deep soft tissue. We reported a woman original meningioma in the lumbar spine with distal deep neck metastasis. Findings: A 59-year-old patient suffered from severe right drop foot, numbness, and radicular pain for the previous 6 months. Computed tomography (CT) disclosed a huge, macrolobulated retroperitoneal soft-tissue lesion with a size of 14.9 × 10.8 × 17.7 cm. Magnetic resonance imaging (MRI) further revealed a solid spinal intracanal tumor with moderate enhancement involving the right ...