Helical tomotherapy in patients with leptomeningeal metastases Sanziana RI Schiopu,1,2 Gregor Habl,3 Matthias Haefner,2 Sonja Katayama,2 Klaus Herfarth,2,4 Juergen Debus,2,4 Florian Sterzing4,5 1Department of Internal Medicine V, Ludwig-Maximilian University, Munich, Germany; 2Department of Radiation Oncology, Heidelberg University, Heidelberg, Germany; 3Department of Radiation Oncology, Klinikum rechts der Isar, Technical University, Munich, Germany; 4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 5Radiation Oncology, Kempten Clinic, Kempten, Germany Purpose: Leptomeningeal metastasis (LM) is an increasingly common complication of late-stage systemic cancer, for which there is no standard treatment. We analyzed outcome and toxicity in patients with LM undergoing craniospinal irradiation via helical tomotherapy (HT-CSI) at our institution. Patients and methods: The charts of 15 patients diagnosed with LM and undergoing HT-CSI between 2006 and

Leptomeningeal metastases from recurrent squamous cell cancer of the skin.: We report two patients with leptomeningeal metastases from squamous cell cancer of t

Reports of gliomas presenting with signs and symptoms of leptomeningeal spread are rare.4 Although estimates of the incidence of leptomeningeal dissemination of gliomas in autopsy series vary, such tumor spread usually develops as a late complication in patients who have been previously treated.2 3 Our patient presented with clinical evidence of a disseminated CNS process involving multiple areas of the neuraxis. Because initial neuroimaging and angiographic studies showed evidence of acute infarctions and a diffuse vasculopathic process, a diagnosis of CNS vasculitis was entertained until subarachnoid glial tumor was demonstrated on open brain biopsy. At autopsy, a relatively small primary glioblastoma was identified in the right basal frontotemporal region, and widespread leptomeningeal metastasis was confirmed. This pattern of a small primary focus with extensive leptomeningeal spread corresponds to the type A pattern of malignant glioma described by Onda et al.1 The neuroimaging findings in ...

Objective: Correlate imaging and survival in a retrospective series of patients with leptomeningeal metastasis (LM). Methods: 240 patients with LM (125 solid tumour patients with positive CSF cytology; 40 solid tumour patients with negative CSF cytology and MRI consistent with LM; 50 lymphoma and 25 leukaemia patients with positive CSF flow cytometry), all considered for treatment, underwent prior to treatment neuraxis MRI and radio-isotope CSF flow studies. Results: Survival was significantly shortened in patients with large volume MRI-defined disease and in patients with CSF flow obstruction irrespective of primary tumour histology. Additionally, cause of death differed wherein patients with large volume of disease or obstructed CSF flow more often died of progressive LM disease. Conclusions: Neuraxis imaging utilizing brain and spine MRI as well as radio-isotope CSF flow studies has prognostic significance and is predictive of median overall survival in this large cohort of patients all ...

TY - JOUR. T1 - Predictors of recurrence in the management of chordoid meningioma. AU - Choy, Winward. AU - Ampie, Leonel. AU - Lamano, Jonathan B.. AU - Kesavabhotla, Kartik. AU - Mao, Qinwen. AU - Parsa, Andrew T.. AU - Bloch, Orin. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms chordoid AND meningioma was performed to identify all reports of pathologically confirmed intracranial CMs. A total of 221 patients were included, comprising 120 females and 101 males. Mean age, MIB-1/Ki67, and tumor size was 45.5 years, 4.3 % (range 0.1-26.6 %), and 4.1 cm ...

Leptomeningeal metastasis from non-small cell lung cancer: Survival and the impact of whole brain radiotherapy Academic Article ...

A microscopic appearance slide review showed a mixoid matrix surrounded by a small strand of meningotelial cells areas, resembling chordoma histology. This was diagnosed as a chordoid meningioma.. Histopathological findings - Multiple fragments of tumor were fixed for classical histological study in 10% formalin; the sections were included in paraffin block, and stained with hematoxylin-eosin (HE). Immunohistochemistry was performed on paraffin sections using monoclonal antibodies to epithelial membrane antigen (EMA) and vimentin. All antisera were used with the avidin biotin complex technique and were visualized using 3,3 diaminobenzidine tetrahydrochloride substrate. Appropriate positive and negative controls were also used. Light microscopy examination revealed tumor characterized by cohesive strands of epithelial cells in a myxoid Alcian-blue positive matrix and a chronic inflammatory response consisting of lymphocytes and plasma cells but without the formation of follicles or germinal ...

A 26-year-old man presented with signs of raised intracranial pressure. CT and MRI of the head demonstrated two separate lesions in the posterior fossa. The radiological differential diagnoses included multiple meningiomas, schwannomas, neurofibromas and subependymomas. Both lesions were surgically resected. Histopathological examination revealed localisations of a leptomeningeal melanocytoma. Leptomeningeal melanocytoma is a rare tumour of the central nervous system. Generally, it has a good prognosis if radical resection can be performed. In cases of subtotal resection, adjuvant radiotherapy should be considered. Local recurrences are common. Less frequently, leptomeningeal metastases and, on rare occasions, distant metastases or progression to malignant melanoma have been described. We describe an unusual case with multiple localisations of melanocytoma in the posterior fossa and spinal canal, with the emphasis being on the radiological findings and diagnosis of this rare tumour. After ...

This pilot clinical trial studies continuous intraventricular methotrexate in treating patients with leptomeningeal disease. Drugs used in chemotherapy,

Sanziana RI Schiopu,1,2 Gregor Habl,3 Matthias Haefner,2 Sonja Katayama,2 Klaus Herfarth,2,4 Juergen Debus,2,4 Florian Sterzing4,5 1Department of Internal...

Jennie W. Taylor, Eoin P. Flanagan, Brian P. ONeill, Tali Siegal, Antonio Omuro, Lisa DeAngelis, Joachim Baehring, Ryo Nishikawa, Fernando Pinto, Marc Chamberlain, Khe Hoang-Xuan, Alberto Gonzalez-Aguilar, Tracy Batchelor, Jean Yves Blay, Agnieszka Korfel, Rebecca A. Betensky, Maria Beatriz S. Lopes, David Schiff ...

1. The primary objectives of this study are: 1. To determine the tolerability of RTA 744 Injection in patients with leptomeningeal

Patients who have received the following types of prior or concurrent therapy, or who have not recovered from the toxic effects of such therapy: 1) investigational drugs less than 4 weeks prior to entry on this study. 2) intrathecal chemotherapy within 2 weeks prior to entry into this study. 3) systemic cytotoxic chemotherapy within 4 weeks prior (6 weeks for nitrosourea or mitomycin-C or 2 weeks for vincristine) to entry on this study. 4) radiation therapy within 2 weeks prior to entry on this study. 5) any medication known to cause QT interval prolongation ...

CSF cytology via lumbar puncture: If the primary tumor was exposed to the CSF compartment (or arose in it), lumbar CSF should be examined for cytology 7-14 days after surgery to exclude CSF dissemination unless there was preoperative evidence of leptomeningeal disease. ...

ABSTRACT Leptomeningeal Metastases LM is a condition in which tumor cells from a primary tumor metastasize invade the subarachnoid space SAS and spread throughout the cerebrospinal fluid CSF resulting in seeding along the meninges brain and spinal cord LM represents a devastating event of cancer progression There are cases annually and currently no cure with average survival of months with current .... ...

Metastases spread to the nervous system through the bloodstream cerebral, spinal, and leptomeningeal metastases , lymphatic vessels metastases to the PNS , and

Patients with leptomeningeal disease (LMD) from melanoma have very poor outcomes and few treatment options. We present a case of intrathecal (IT) administration of autologous tumor infiltrating lymphocytes (TIL) in a patient with LMD from metastatic melanoma. The patient developed LMD after previous treatments with surgery, high-dose bolus interleukin-2 (HD IL-2), and systemic TIL infusion and experienced radiographic progression after intrathecal IL2 (IT IL-2) therapy. The patient received weekly treatment with increasing numbers of IT TIL followed by twice-weekly IT IL-2. The patient received three TIL infusions and did not experience any toxicities beyond those expected with IT IL-2 therapy. Analysis of cerebrospinal fluid (CSF) demonstrated increased inflammatory cytokines following the intrathecal treatments. Subsequent imaging demonstrated disease stabilization, and neurological deficits also remained stable. The patient expired five months after the initiation of IT TIL therapy with ...

Inclusion Criteria: - Previously untreated metastatic or unresectable, recurrent head and neck squamous cell carcinoma. - Adequate Bone Marrow Function. - Adequate Renal & Liver Function. - Adequate Performance Status Exclusion Criteria: - Patients with known symptomatic CNS metastases or leptomeningeal disease requiring steroids. - History of (non-infectious) pneumonitis that required steroids or current pneumonitis. - Prior treatment with any anti-CD47 or anti-SIRPα agent. - Prior treatment with anti-PD-1 or PD-L1 ...

Purpose: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due to the absence of truly restricted antigen expression and potential safety concerns with on-target off-tumor activity. Here, we have optimized HER2-CAR T cells for the treatment of breast to brain metastases, and determined optimal second generation CAR design and route of administration for xenograft mouse models of breast metastatic brain tumors, including multifocal and leptomeningeal disease. Experimental Design: HER2-CAR constructs containing either CD28 or 4-1BB intracellular co-stimulatory signaling domains were compared for functional activity in vitro by measuring cytokine production, T cell proliferation, and tumor killing capacity. We also evaluated HER2-CAR T cells delivered by intravenous, local intratumoral, or regional intraventricular routes of administration using in vivo human ...

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TY - JOUR. T1 - Single-fraction radiosurgery of benign intracranial meningiomas. AU - Pollock, Bruce E.. AU - Stafford, Scott L.. AU - Link, Michael J.. AU - Brown, Paul D.. AU - Garces, Yolanda I.. AU - Foote, Robert L.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - BACKGROUND:: Stereotactic radiosurgery (SRS) of benign intracranial meningiomas is an accepted management option for well-selected patients. OBJECTIVE:: To analyze patients who had single-fraction SRS for benign intracranial meningiomas to determine factors associated with tumor control and neurologic complications. METHODS:: Retrospective review was performed of 416 patients (304 women/112 men) who had single-fraction SRS for imaging defined (n = 252) or confirmed World Health Organization grade I (n = 164) meningiomas from 1990 to 2008. Excluded were patients with radiation-induced tumors, multiple meningiomas, neurofibromatosis type 2, and previous or concurrent radiotherapy. The majority of tumors (n = 337; 81%) involved the cranial base ...

Introduction: Meningiomas are predominantly benign tumors, which arise from the arachnoids cap cells. The development mechanism is unknown but they may result from an adverse effect of cranial irradiation and trauma. Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. Materials and Methods: This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. The study included samples from intracranial meningioma patients ...

Extracranial meningiomas are classified according to Hoye et al. [4]. Primary extracranial meningioma and secondary extracranial meningioma can be classified according to the presence or absence of an intracranial meningioma. Primary extracranial meningiomas are composed of two types: a tumor originating from arachnoid cells remaining in the nerve sheaths and a tumor occurring ectopically without connection to the cranium. Secondary extracranial meningiomas are classified as intracranial tumors directly escaping from the cranium and extracranial meningioma that has metastasized from an intracranial meningioma [6]. According to this classification, our case is classified as an ectopic primary extracranial meningioma.. Intradural meningioma is known to be associated with radiation, virus, head trauma, smoking, nitrate, and high cholesterol levels, but the cause of primary extracranial meningioma is not yet clear. Possible hypotheses are as follows: (1) migration of arachnoid cells along the ...

meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.

Cases reported • Meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.

A meningioma is a type of brain tumor thats said to be to second most common type of brain tumor occurring in humans today. A meningioma brain tumor primarily develops in the meninges, the thin layers of tissue surrounding the spinal cord and the brain. In most cases, these brain tumors can grow in size and spread, although its difficult to determine the tumors growth rate. Upon growth, these tumors put pressure on surrounding brain tissue.. Meningiomas can be classified into three grades, as set by the World Health Organization. Grade I meningiomas are classified as benign, Grade II meningiomas are identified as atypical, while Grade III meningiomas are considered anaplastic. Meningiomas are usually benign, but Grade III meningiomas are malignant. The average survival rate for Grade III meningiomas, without relapse, is currently at about three years.. There are some factors that contribute to the development of brain tumors in the meninges. Excessive exposure to ionizing radiation or x-rays ...

Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state. Consistent with this observation, atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks. Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. Our results ...

This report presents magnetic resonance imaging (MRI) findings of a breast carcinoma metastasis in an intracranial meningioma with correlated pathological findings. MRI showed multiple foci of intense enhancement with hypointense surrounding areas. The described foci appeared to be metastatic disease from the patients known breast carcinoma. In addition, this is the first study reported in the literature to have investigated the expression of a possibly common carcinogenic molecule in breast carcinoma metastatic to a coexisting meningioma: overexpressed c-myc oncogene was found both in the breast carcinoma compartment and in the meningioma component of the tumor. ...

Coexistence of pituitary adenoma, intracranial meningioma and cerebral aneurysm has never been described. We report on a patient with GH-secreting pituitary macroadenoma associated with a right...

Twenty four meningiomas (17 benign and seven atypical were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost exclusively of the CD8 subtype, were also present in 70% of benign meningiomas and in all atypical meningiomas and were more abundant in the latter. B lymphocytes were present in minimal numbers in three atypical meningiomas and in one benign meningioma. CD4 positive T lymphocytes were present in small numbers in one benign meningioma and in moderate numbers in one atypical meningioma. HLA DR antigen expression on tumour cells was present in about 60% of both tumour groups. The numbers of macrophages and T and CD8 lymphocytes in meningiomas seem to be related to atypical histological features, and the presence of these cells raises questions about host immune response and the relation of this to prognosis.. ...

Intraventricular Malignant Meningioma - Malignant meningioma· Intraventricle· Frontal horn· Third ventricle· Surgical approach.J Korean Neurosurg Soc 34 : 379-381;KISEP380 J Korean Neurosurg Soc 34Intraventricular Malignant Meningiomaand was removed a piecemealfashion using biopsy forceps

TY - JOUR. T1 - Preoperative Embolization of Intracranial Meningiomas. AU - Yoshida, Kazunari. AU - Toya, Shigeo. AU - Takamiya, Yoshiaki. AU - Murakami, Hideki. AU - Kawase, Takeshi. AU - Shiga, Hayao. PY - 1985. Y1 - 1985. N2 - The method and results for preoperative embolization are described in 36 cases with intracranial meningiomas. Embolization materials were injccted through a transfemoral catheter, selectively placed in the external carotid artery. Chopped gelfoam served as embolization material in 29 patients and ivalon particles were used in 7 patients. In 19 out of 36 cases the feeding arteries arose only from the external carotid artery system and were completely occluded (complete embolization) except in 3 cases. The remaining 17 cases also had feeders of the tumor capsule or at the site of the insertion arising from the internal carotid artery system (partial embolization). Thirty-three cases were followed by computed tomography (CT) between embolization and operation. Contrast ...

TY - JOUR. T1 - Anatomic location is a risk factor for atypical and malignant meningiomas. AU - Kane, Ari J.. AU - Sughrue, Michael E.. AU - Rutkowski, Martin J.. AU - Shangari, Gopal. AU - Fang, Shanna. AU - McDermott, Michael W.. AU - Berger, Mitchel S.. AU - Parsa, Andrew T.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/3/15. Y1 - 2011/3/15. N2 - BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I meningiomas after surgery and/or external irradiation. As the utility of noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess the likelihood that a tumor is not benign before treatment initiation. Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location. METHODS: The authors reviewed 378 patients presenting at their institution from 2000 to 2007 with histologically ...

The aim of this work was to study the vascular endothelial growth factor A (VEGF-A) pathway and peritumoral brain edema (PTBE) through comparison of non-angiomatous and angiomatous meningiomas. Meningiomas are common intracranial tumors, which often have PTBE. VEGF-A is an integral part of PTBE formation and angiogenesis, and the capillary-rich angiomatous meningiomas are known for their PTBE. The VEGF-A receptor VEGFR-2 is responsible for the angiogenic effect of VEGF-A on endothelial cells, which is enhanced by the co-receptor neuropilin-1. Forty non-angiomatous, 22 angiomatous meningiomas, and 10 control tissue samples were collected for the study. Magnetic resonance images were available for 40 non-angiomatous and 10 angiomatous meningiomas. Tissue sections were immunostained for CD34, MIB-1, estrogen- and progesterone receptors. ELISA, chemiluminescence, and RT-qPCR were used for VEGF-A, VEGFR-2, and neuropilin-1 protein and mRNA quantification. Angiomatous meningiomas had larger PTBE (695 ...

A case of malignant meningioma which has grown rapidly after gross total removal and metastasized to thoracic spines after second operation is reported. We recommend that early spinal magnetic resonance image should be performed in patient with spinal symptoms and signs after the treatment of intracranial meningioma and intensive treatment combined with operation and radiosurgery should be performed for the reduction of growth rate in the recurred malignant meningoma. ...

Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients.. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and his team will determine the plasma exposure and brain accumulation of LEE011 following 5-day dosing in patients with recurrent atypical and malignant meningiomas; will evaluate select PD biomarkers corresponding to CDK4/6 inhibition, including Rb phosphorylation, cells in M-phase of cell cycle (PH3), and FoxM1 downregulation and explore the safety and efficacy of LEE011 in recurrent atypical and malignant meningioma with demonstrated pharmacokinetic and pharmacodynamic effects.. Dr. Sanai shares, What drives me forward is the opportunity to discover things that others in humankind have never seen, as we as find ...

Temporal bone meningioma can be considered as a part of the ectopic meningioma group. The known female preponderance of intracranial meningiomas is also seen in external auditory canal meningioma.4 Up to 20% of intracranial meningiomas may have extraneuraxial extension, 5,6,7,8. including the skull, scalp (all cutaneous sites), orbit, upper airway involvement (nasal cavity, paranasal sinuses, nasopharynx), soft tissues, and ear / temporal bone. However, when the scalp, orbit, sinonasal tract, oral cavity, and soft tissues are excluded, the incidence decreases to ,1% 6, 9, 10, 11. Ectopic or extracranial meningiomas are classified into 4 subgroups: direct extension from primary intracranial meningioma, extracranial growth from cranial nerve sheath arachnoidcells, extracranial extension from embryonic arachnoid rests without connection to the skull base or cranial nerves, and distant metastasis from intracranial tumors.3 Meningioma gains access to the temporal bone from 3 principal sites of ...

Introduction Forkhead Box M1 (FOXM1) and aryl hydrocarbon receptor (AHR) signaling pathway participate in meningioma development, but their correlation was inadequately studied. The study is aimed to uncover their functions and correlation in malignant meningioma. Material and methods...

Intracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles. Here, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors. We conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells

MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability ...

Meningiomas, which invade intracranial bone structures and the adjacent connective tissue, are frequently unresectable because of their aggressive and recalcitrant growth behavior. They have a high recurrence rate, and in approximately 10% of these tumors there is an increased risk of malignancy. Significant morbidity and mortality rates associated with recurrent meningiomas demand nonsurgical approaches. To date, adjuvant hormonal treatment has not proven beneficial. The anticancer drug hydroxyurea was therefore tested for its potential use in the treatment of meningiomas.. Early-passaged cell cultures were established from 20 different meningiomas. The addition of 5 X 10−4 and 10−3 M hydroxyurea over a period of 5 to 9 days resulted in a remarkable decrease in cell proliferation and even blocked tumor cell growth when compared with untreated cells. A significant arrest of meningioma cell growth in the S phase of the cell cycle was revealed on DNA flow cytometry.. Electron micrographs of ...

MENINGIOMA. Meningiomas are extra-axial tumours and represent the most common tumour of the meninges. They are a non-glial neoplasm that originates from the arachnoid cap cells of the meninges. They are typically benign with a low recurrence rate but rarely can be malignant.. Typical meningiomas appear as dural based masses isointense to grey matter on both T1 and T2 weighted imaging, and demonstrate vivid contrast enhancement on both MRI and CT. There are, however, many variants some of which can vary dramatically in their imaging appearance. Epidemiology. Meningiomas are more common in women, with a ratio of 2:1 intracranially and 4:1 in the spine. Atypical and malignant meningiomas are slightly more common in males. They are uncommon in patients before the age of 40 and should raise suspicion of neurofibromatosis type 2(NF2) when found in young patients.. Grading. Generally follows the WHO classification for CNS tumours:. ...

TY - JOUR. T1 - 18F-Choline PET/CT in Leptomeningeal Breast Cancer Metastases. AU - Cuppari, Lea. AU - Reccia, Pasquale. AU - Burei, Marta. AU - Cervino, Anna Rita. AU - Evangelista, Laura. PY - 2019/2. Y1 - 2019/2. N2 - We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights that F-choline PET would be used for the identification of leptomeningeal involvement in patients affected by breast cancer, as a support of MRI images.. AB - We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights ...

Meningiomas account for around 25% of primary brain tumours, and most often occur between the age of 40 and 70 years. They are more common in females. Atypical meningiomas are more aggressive than benign meningiomas, and account for around 5% of all meningiomas. Around 4% of meningiomas are malignant ...

Anaplastic meningiomas (also known as malignant meningiomas) are uncommon, accounting for only ~1% of all meningiomas 1. Along with rhabdoid meningioma and papillary meningioma are considered WHO grade III tumors and demonstrate aggressive local ...

TY - JOUR. T1 - Optic nerve seeding of atypical meningiomas presenting with subacute visual loss. T2 - 2 case reports with genetic characterization. AU - Kitamura, Yohei. AU - Akiyama, Takenori. AU - Sasaki, Hikaru. AU - Hayashi, Yuichiro. AU - Yoshida, Kazunari. PY - 2013/8. Y1 - 2013/8. N2 - Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical ...

Meningiomas are tumours of the membranes that cover the brain. Meningiomas are described as atypical when the tumor cells do not appear typical or normal. The standard treatment for patients with atypical meningioma is surgery to remove the tumour. Radiotherapy to kill any tumour cells left behind after surgery (post-operative radiotherapy) can increase the patient survival rate. The aim of this study is to find out whether a form of radiotherapy called carbon ion boost in combination with post-operative photon radiotherapy can improve the patient survival rate after 3 years ...

Authors reviewed 92 cases of intracranial meningiomas which confirmed by operation at the Department of Neurosurgery, Seoul National University Hospital from September 1957 to July 1982. 45 cases out of 50 cases that had performed computerized tomographic(CT) scans preoperatively were analyzed. The results were as following ; 1) Meningiomas constituted 12.4% of all intracranial tumors. There were 51 women and 41 men(55.4%/44.6%). The average age at the time of diagnosis was 41.2 years. 2) The initial symptoms were headache(50.0%), visual disturbance(14.1%), and seizure(8.7%) in the order. 3) The most common location was parasagittal-falcial, and followed by convexity, sphenoid ridge, tuberculum sellae tentorial and olfactory groove. 4) 61 cases(76%) out of 80 cases showed abnormal findings in the plain skull X-ray examinations. The preenhanced CT scans(45 cases) showed hyperdense lesion in 57.8%(26 cases), isodense lesion in 35.6%(16 cases), and hypodense lesion in 6.6%(3 cases). The incidence ...

TY - JOUR. T1 - A Systematic Review of Ion Radiotherapy in Maintaining Local Control Regarding Atypical and Anaplastic Meningiomas. AU - Coggins, William S.. AU - Pham, Nguyen K.. AU - Nguyen, Anthony V.. AU - Branch, Daniel W.. AU - Guillet, June Y.. AU - Korst, Genevieve. AU - Lall, Rishi R.. PY - 2019/12. Y1 - 2019/12. N2 - Objective: Atypical and anaplastic meningiomas, unlike their benign counterparts, are highly aggressive, locally destructive, and likely to recur after treatment. These diseases are difficult to definitively treat with traditional radiotherapy without injuring adjacent brain parenchyma. The physical properties of ion radiotherapy allows for treatment plans that avoid damaging critical neural structures. The objectives of this systematic review were to evaluate the use and efficacy of ion radiotherapy in the treatment of atypical and anaplastic meningiomas. Methods: We performed a systematic review of the literature by querying the PubMed and Ovid databases to identify and ...

Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, 10% are classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas. Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon. Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation. Here, we report that additional nullizygosity for p16Ink4a increases the frequency of meningioma and meningothelial proliferation in these mice without modifying the tumor grade. In addition, by using ...

TY - JOUR. T1 - Cognitive outcomes in meningioma patients undergoing surgery. T2 - Individual changes over time and predictors of late cognitive functioning. AU - Rijnen, S.. AU - Meskal, I.. AU - Bakker, M.. AU - Rutten, G.. AU - Gehring, K.. AU - Sitskoorn, M.. PY - 2018. Y1 - 2018. U2 - 10.1093/neuonc/noy139.387. DO - 10.1093/neuonc/noy139.387. M3 - Meeting Abstract. VL - 20. SP - iii317-iii317. JO - Neuro-Oncology. JF - Neuro-Oncology. SN - 1522-8517. IS - suppl 3. ER - ...

TY - THES. T1 - Cognitive functioning in meningioma patients. T2 - Insights in individual test performances and changes of performance after surgery. AU - Meskal, Ikram. PY - 2018. Y1 - 2018. M3 - Doctoral Thesis. SN - 978-94-6375-224-4. PB - Ridderprint. CY - s.l.. ER - ...

Meningioma is the most common extra-axial benign brain tumor. It is more common in females than males. Meningioma has both typical and atypical features. The diagnosis of typical meningioma is easier than atypical. Major differential diagnoses fo...

3Sakarya Training and Research Hospital, Department of Pathology, Sakarya, Turkey DOI : 10.5137/1019-5149.JTN.9907-13.1 With an incidence rate of 15-20%, meningiomas are one of the most common brain tumors among benign intracranial tumors. They are distributed as follows in intracranial localizations: parasagittal and falx (25%), convexity (18%), sphenoid wing (18%), parasellar (12%), posterior fossa (10%), intraventricular (2%), intraorbital (1%), and extracranial (1%). The most common extradural localizations are the paranasal sinuses, nasal cavity, skin, neck, glands, and intraosseous space. Intradiploic meningiomas are generally localized in the frontoparietal and orbital regions. Due to their low incidence and lack of adequate preoperative diagnostic testing, intradiploic meningiomas are generally mistaken for primary calvarial bone tumors and en plaque meningiomas. Our case was discussed here with literature findings since primary intradiploic meningioma is uncommon and poses diagnostic ...

Introduction. Meningiomas are extra-axial tumors,generally benign, originated by arachnoid cell degene-ration. They are more common in adults (40-60 years)and females. In 1973, Manelfe et al. first described preo-perative embolization of some meningiomas histotypes.Since then, the technique has remarkably improved, byusing micro-catheters and with the development ofmaterials used to perform the procedure, along withthe growing experience of neurosurgeons and neuro-radiologists. Several authors have shown that the pro-cedure reduces intraoperative bleeding. However, preo-perative embolization is still a matter of debate.Object. The objective of this study was to determinatethe benefits of preoperative embolization usingpolyvinyl alcohol (PVA) in selected patients, highlightingclinical indications to safely perform the technique.Materials and Methods. In the last 12 years, 50 patien-ts (13 males and 37 females, mean age 60.5) with adiagnosis of meningioma, underwent Digital Subtrac-tion ...

TY - JOUR. T1 - Metastatic meningioma in fine-needle aspiration (FNA) of the lung. T2 - Cytomorphologic finding. AU - Baisden, Blaire L.. AU - Hamper, Ulrike M.. AU - Ali, Syed Z.. PY - 1999/5. Y1 - 1999/5. N2 - Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellularity with large syncytial groups of monomorphic cells with epithelioid morphologic features, often in perivascular arrangements. Occasional intranuclear cytoplasmic inclusions as well as binucleated cells with wispy cytoplasmic extensions were also noted. Immunoperoxidase studies showed focal positivity for epithelial membrane antigen. The differential diagnosis includes primary or metastatic adenocarcinoma, malignant mesothelioma, and melanoma.. AB - Pulmonary metastasis ...

Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013 Aug;68[8]:837-44. http://dx.doi.org/10.1016/j.crad.2013.03.007 PMid:23623578 Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. 2013;13(4):337. http://dx.doi.org/10.1007/s11910-013-0337-4 PMid:23463172 Osborn AG, Salzman KL, Barkovich AJ. Meningioma and atypical and malignant meningioma. In: Osborn AG, editor. Diagnostic imaging: brain. 2nd ed. Salt lake city: Lippincott Williams & Wilkins/Amirys, 2009: p. 72-81. de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J Clin Neurosci. 2009;16:1246 9. http://dx.doi.org/10.1016/j.jocn.2008.11.017 PMid:19560362 Goncalves AM, Page P, Domigo V, Meder JF, Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol. 2010;31:1504 5. http://dx.doi.org/10.3174/ajnr.A1978 PMid:20053802 Shimizu J, Matsumoto M, Yamazaki ...

2Hacettepe Üniversitesi Tıp Fakültesi Beyin Cerrahisi Anabilim Dalı, Ankara Meningiomas represent approximately 13-26% of primary intracranial tumours. Many small meningiomas have no symptoms during life and may be found incidentally at autopsy. Such incidental meningiomas are detected more frequently in recent years because of the advent of CT and MRI. Malignant (anaplastic) meningiomas are less common lesions, accounting for 1-2.8% of meningiomas. Recently, clear cell and chordoid meningiomas have been classified as WHO Grade II and rhabdoid and papillary meningiomas classified as WHO Grade III tumors without pathological criteria for malignancy. Here we report a rare case of rhabdoid meningioma in a 31 year-old man. Using the presented case we discuss the prognostic significance of recognition of a rhabdoid meningioma in light of the literature. Anahtar Kelimeler : Meningioma, rhabdoid meningioma, prognostic significance ...

Background: Meningioma is one of the primary brain tumors that most often occurs at the age of 60-70 years, originating from arachnoid cap cells. FGF-2 as a growth factor is a potent stimulator of endothelial proliferation which is very important in the process of angiogenesis. FGF-2 levels in meningiomas have been assessed using the ELISA and qrPCR methods in many previous studies using blood serum in malignant cases with normal brain tissue as control. This study used tissue samples of meningioma tumors in which most cases of meningioma are benign. Objective: To assess the association between immunohistochemical expressions of FGF-2 and histopathology grade among meningioma patients. Material and Method: Formalin-fixed paraffin-embedded tissue blocks of 32 meningioma patients were immunohistochemically studied for FGF-2 expression. The basic characteristics of the samples were obtained through medical records or pathology archieves. The association between FGF-2 expression and grade were ...

Intracranial aneurysms and meningiomas are rarely associated. We review the concerned literature, and report a patient operated for an anterior communicating artery aneursym, found at surgery to harbour a small ipsilateral meningioma at the lesser wing of the sphenoid. We also review the proposed causes of such an association. Factors related to the meningioma are usually thought to be behind the development of associated aneurysms. Considering the size of the meningioma in our patient, we believe that both lesions form concomitantly under the effect of certain genetic or systemic factors, influenced by local circulatory changes. These factors are to be determined with more basic science research ...

Answer: Meningioma, WHO grade I. Histology: The lesion is comprised of bland spindled cells arranged in clusters and whorls with focal intranuclear pseudoinclusions and frequent psammoma bodies. No mitotic figures are identified. No nuclear pleomorphism or necrosis is present. No brain invasion is identified.. Discussion: Meningiomas are common brain tumor arising from the dura covering the brain, and they are the most common benign brain tumor. They are more common in women and are usually solitary, but may be multiple, particularly when associated with neurofibromatosis type 2 (NF2), which is a defect in the NF2 gene encoding merlin on chromosome 22. Up to 60% of isolated or sporadic meningiomas also display somatic mutations in the NF2 gene (1). By immunohistochemistry, meningiomas are positive for progesterone receptor (PR) and EMA, which can be used in difficult cases to support a meningothelial origin. The majority of meningiomas (90%) are WHO grade I. Certain histologic variants are ...

Professor Richard Houlston from The Institute of Cancer Research led the major international collaboration comparing the DNA of 1,633 meningioma patients and 2,464 healthy controls, using a technique known as a genome-wide association study.. Relatives of people with meningiomas are three times more likely to develop the disease but little is known about what increases their risk. A small proportion of meningiomas are linked to four rare genetic diseases called neurofibromatiosis type-2, Coden, Werner and Gorlin symdromes.. Professor Houlston said: We knew that people with certain rare inherited diseases are more likely to develop meningiomas. Although these inherited diseases significantly increase the chance of getting this type of brain cancer, they are so rare that they account for a very small proportion of the increased risk among relatives of people with meningiomas. Our study begins to shed light on the biggest part of the inherited risk.. The genetic region weve found is very closely ...

Meningioma Mommas is asking for help to fund an exciting new project by the team of University of Colorado researchers we have previously funded. Please help us help the researchers find better treatment options for meningioma patients by donating here or via our own Donate page.. From the researchers:. PROJECT SUMMARY. Meningiomas are a common brain tumor, considered to be the most prevalent primary brain tumor in the central nervous system. In spite of their burden, no FDA approved pharmacotherapies exist for the treatment of these tumors. Through our work with Meningioma Mommas, we have created a high throughput drug screen that allows us to directly measure the sensitivity of individual tumors to hundreds of FDA approved compounds. This approach has identified several possible treatments that have the ability to treat meningiomas broadly by targeting epigenetic processes. Many of the drugs in this class can cross the blood brain barrier making these ideal candidates for further studies. ...

see Venous infarction. Venous air embolism (VAE) during an elective craniotomy for parasagittal meningioma resection. The surgery was done in the supine position with slightly elevated head position. VAE was provisionally diagnosed by sudden decreased in the end tidal carbon dioxide pressure from 34 to 18 mmHg, followed by marked hypotension and atrial fibrillation. Prompt central venous blood aspiration, aggressive resuscitation and inotropic support managed to stabilize the patient. Post operatively, he was admitted in neuro intensive care unit and made a good recovery without serious complications 15).. Intraoperative fatal pulmonary embolism 16).. Paraparesis can occur as a primary presentation of brain pathology at the motor strip along the parasagittal region. It could also occur as a neurological complication especially following resection of parasagittal meningioma with infiltration of the superior sagittal sinus (SSS). We report a case of a complete paraparesis immediately following ...

Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and…. ...

BACKGROUND: Radiosurgery is the main alternative to microsurgical resection for benign meningiomas. OBJECTIVE: To assess the long-term efficacy and safety of radiosurgery for meningiomas with respect to tumour growth and prevention of associated neurological deterioration. Medium to long-term outcomes have been widely reported, but no large multicentre series with long-term follow-up have been published. METHODS: […]. Read more of this post. Add a comment to this post. ...

Meningiomas are uncommonly associated with cysts and account for 1.6-10% of intracranial meningiomas 1) 2) 3) Those with more numerous smaller peripheral cysts are more frequent (8-23% of cases). They are over-represented in male patients and the paediatric population Clinical presentation Patients present clinically in the same way as patients with non-cystic meningiomas, with either symptoms related to increased intracranial pressure (ICP), focal neurology, or seizures. Pathology Various mechanisms have been proposed, and probably more than one is applicable depending on the location of the cysts: degeneration or necrosis direct secretion by meningioma reactive changes (peripheral arachnoid cysts) Classification Nauta et al. divided cystic meningiomas into four subtypes according to the location of the cyst with respect to the brain and meningioma type 1: intratumoral cyst(s), located centrally within the meningioma type 2: intratumoral cyst(s), situated peripherally within the meningioma but ...