... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
TY - JOUR. T1 - Numb chin syndrome secondary to leptomeningeal carcinomatosis from gastric adenocarcinoma. AU - Riesgo, Vincent J.. AU - Delgado, Silvia. AU - Poveda, Julio. AU - Rammohan, Kottil W. PY - 2015. Y1 - 2015. N2 - Numb chin syndrome (NCS) can be a sign of malignancy. Its association with gastric adenocarcinoma is rare. We report a case of a 27-year-old Hispanic female that presented with complaint of left sided headache associated with numbness of the left side of chin and lower gingiva. Initial brain MRI, whole body gallium scan, high resolution CT of chest and elevated protein in the CSF were suggestive of sarcoidosis. She was treated with IV steroids with transient clinical improvement. Two weeks later, her symptoms worsened and further evaluation revealed the diagnosis of a poorly differentiated metastatic gastric adenocarcinoma with leptomeningeal involvement. This case report aims to emphasize the importance of identifying NCS as a possible indication of an underlying malignant ...
Leptomeningeal carcinomatosis (LMC) is the multifocal seeding of cerebrospinal fluid and leptomeninges by malignant cells. The incidence of LMC is approximately 5% in patients with malignant tumors overall and the rate is increasing due to increasing survival time of cancer patients. Eradication of the disease is not yet possible, so the treatment goals of LMC are to improve neurologic symptoms and to prolong survival. A standard treatment for LMC has not been established due to low incidences of LMC, the rapidly progressing nature of the disease, heterogeneous populations with LMC, and a lack of randomized clinical trial results. Treatment options for LMC include intrathecal chemotherapy, systemic chemotherapy, and radiation therapy, but the prognoses remain poor with a median survival of <3 months. Recently, molecular targeted agents have been applied in the clinic and have shown groundbreaking results in specific patient groups epidermal growth factor receptor (EGFR)-targeted therapy or an
We describe a case of a 67-year-old man with known chronic obstructive pulmonary disease, type 2 diabetes mellitus, hypertension, osteoarthritis, previous history of excess alcohol intake, and oesophagectomy 3 years earlier for T3N0 adenocarcinoma, referred by his general practitioner with confusion, weight loss and several recent falls. CT of the chest, abdomen and pelvis revealed a right middle-lobe pulmonary embolism, while CT of the head revealed a communicating hydrocephalus. Lumbar puncture was performed, and empirical treatment for tuberculous and fungal meningitis was commenced. Unfortunately, he suffered a rapid neurological deterioration with markedly elevated cerebrospinal fluid (CSF) pressures, leading to an external ventricular drain. Cytological analysis of a CSF sample revealed a cellular infiltrate consistent with leptomeningeal carcinomatosis (adenocarcinoma), with the previous oesophageal malignancy the likely primary. He passed away 17 days after hospital admission. Prolonged ...
TY - JOUR. T1 - Extensive Involvement of Multiple Cranial and Spinal Nerves in Lymphomatous Meningitis. AU - Cordano, Christian. AU - Nourbakhsh, Bardia. AU - Brown, Ethan. AU - Glastonbury, Christine. PY - 2017/9/1. Y1 - 2017/9/1. KW - B-cell lymphoma. KW - Lymphomatous meningitis. KW - ophthalmoparesis. UR - http://www.scopus.com/inward/record.url?scp=85030784037&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85030784037&partnerID=8YFLogxK. U2 - 10.1017/cjn.2017.50. DO - 10.1017/cjn.2017.50. M3 - Comment/debate. C2 - 28482940. AN - SCOPUS:85030784037. VL - 44. SP - 599. EP - 600. JO - Canadian Journal of Neurological Sciences. JF - Canadian Journal of Neurological Sciences. SN - 0317-1671. IS - 5. ER - ...
TY - JOUR. T1 - 18F-Choline PET/CT in Leptomeningeal Breast Cancer Metastases. AU - Cuppari, Lea. AU - Reccia, Pasquale. AU - Burei, Marta. AU - Cervino, Anna Rita. AU - Evangelista, Laura. PY - 2019/2. Y1 - 2019/2. N2 - We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights that F-choline PET would be used for the identification of leptomeningeal involvement in patients affected by breast cancer, as a support of MRI images.. AB - We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights ...
Leptomeningeal carcinomatosis occurs in patients with cancer at the rate of approximately 5%; it develops particularly in patients with breast cancer, lung cancer, melanoma, leukemia, or malignant lymphoma. We describe a rare case of leptomeningeal carcinomatosis in which spinal intradural squamous cell carcinoma with no lesions in the cerebral meninges and leptomeninx, was the primary lesion. A 64-year-old man complained of sacral pain. Although the patient was treated with analgesics, epidural block and nerve root block, sacral pain persisted. Since acute urinary retention occurred, he was operated on. The patient was diagnosed as having an intradural squamous cell carcinoma of unknown origin. Since the patient presented with a slightly decreased level of consciousness 2 months after surgery, he was subjected to MRI scanning of the brain and spinal cord, which revealed disseminated lesions in the medulla oblongata. The patient died of pneumonia and sepsis caused by methicillin-resistant Staphylococcus
A925L/AR cells were moderately resistant to various ALK-TKIs, such as alectinib, crizotinib, ceritinib, and lorlatinib, compared with parental cells in vitro. A925L/AR cells acquired the resistance by epidermal growth factor receptor (EGFR) activation due to amphiregulin overexpression caused by decreased expression of microRNA-449a. EGFR-TKIs and anti-EGFR antibody re-sensitized A925L/AR cells to alectinib in vitro. In the LMC model with A925L/AR cells, combined treatment with alectinib and EGFR-TKIs, such as erlotinib and osimertinib, successfully controlled progression of LMC. Imaging mass spectrometry showed accumulation of the EGFR-TKIs in the tumor lesions. Moreover, notably higher amphiregulin levels were detected in CSF from alectinib-resistant ALK-rearranged NSCLC patients with LMC (N=4), compared with those in EGFR-mutated NSCLC patients with EGFR-TKI-resistant LMC (N=30) or patients without LMC (N=24 ...
ecancermedicalscience is the peer-reviewed open access cancer journal founded by the European Institute of Oncology in Milan. We consider articles on all aspects of research relating to cancer, including molecular biology, genetics, pathophysiology, epide
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Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology and neuroinflammation research, and coverage extending to other basic and clinical studies related to neuroscience.
This pattern of abnormal intracranial enhancement in a patient with breast cancer is best explained by leptomeningeal carcinomatosis (metastases), particularly given the patient has several enhancing intracerebral nodules.
Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding-non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem-of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review. We hypothesized that the restricted diffusion along the anterior brainstem was caused by malignant cells concentrating in the cistern around the brainstem and infiltrating into the circumferential perforating arteries along the anterior brainstem surface, which then resulted in microinfarctions.
Patients with gynecologic malignancies may develop metastases throughout the neuraxis. Cervix-related carcinomatous meningitis is a distinctly unusual clinical event with only two previous cases reported in the English medical literature. We review c
Laboratory work-up showed mild elevation of C-RP. Cerebrospinal fluid (CSF) analysis revealed lymphocytic pleocytosis (20 cells/µL), hypoglicorrhachia of 42% and hyperproteinorrhachia. Head CT was unremarkable. She started empiric treatment for bacterial meningitis, without clinical improvement in the following days. Brain MR study revealed, in the post-contrast sequences, an infratentorial leptomeningeal enhancement mainly in the sulci of both cerebellar hemispheres, with involvement of the vermis. At the supratentorial region, there was also enhancement of the infundibulum of the pituitary stalk and also leptomeningeal enhancement of some sulci. Due to these image findings, the hypothesis of meningitis, mainly TBM, neurosarcoidosis and leptomeningeal carcinomatosis were considered. She started anti-tuberculosis treatment and corticosteroids, and TBM was later confirmed by detection of Mycobacterium Tuberculosis in CSF by polymerase chain reaction.. Conclusion ...
Miliary brain metastasis is an extremely rare form of brain metastasis which can present with atypical imaging findings. We report the case of a patient with miliary brain metastasis of lung cancer showing calcification in metastatic lesions. A 68-year-old Japanese woman was diagnosed with lung adenocarcinoma. Brain computed tomography revealed multiple small calcified lesions in both cerebral hemispheres. Mutation of the epidermal growth factor receptor gene (exon 21, L858R) in lung cancer cells was detected, and treatment with gefitinib was initiated. A partial response was observed; however, the patient was readmitted to our hospital because of regrowth of the primary lesion and complaints of nausea, headache, and difficulty walking. Brain magnetic resonance imaging revealed scattered tiny nodules enhanced by gadolinium. A diagnosis of leptomeningeal carcinomatosis was made on the basis of cerebrospinal fluid cytology. The patients general status worsened, and she died 356 days after the day of
After successfully battling lung cancer in 2009, Valerie Harper thought she had the disease beat. But as the television icon, 73, reveals in this weeks PEOPLE, she is now fighting cancer again - and this time it is an even more formidable foe. On Jan. 15 she received a diagnosis of leptomeningeal carcinomatosis, a rare condition that occurs when cancer cells spread into the fluid-filled membrane - known as the meninges - surrounding the brain. The incurable disease, which accounts for less than 2% of all cancers, "comes on quickly and progresses quickly," says Harpers oncologist, Dr. Ronald Natale, director of the Lung Cancer Research Program at Cedars-Sinai Medical Center in Los Angeles. It can prove fatal in as few as three months. "This is a really complicated condition," says Dr. Jeremy Rudnick, Harpers neuro-oncologist. "The spinal fluid is a collection of fluid thats being circulated [through the brain] kind of like a sink. The fluid itself is growing cancer cells so they are ...
History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, except for individuals who have previously treated parenchymal CNS metastases, are asymptomatic, and have had no requirement for steroids or anticonvulsants for ,2 months prior to study enrollment. Routine screening with CNS imaging studies (computed tomography [CT] or magnetic resonance imaging [MRI]) is required only if clinically indicated, or if the patient has a history of CNS metastases ...
1. Good news - no blood clots. 2. Brain MRIs recommended every 6 months for lung cancer patients 2 years out from diagnosis. 3. Afatinib + cetuximab has not been shown to cross the blood-brain barrier. 4. No good data regarding onset, duration, or tumor strains/characteristics likely to lead to Leptomeningeal Carcinomatosis. 5. Fear sucks.…
Patients will start taking gefitinib daily by mouth on Day 1 and will continue taking this medication daily at home. On the first day the patient takes gefitinib and on Day 14 of each treatment cycle (1 cycle equals 28 days), the patient will undergo: Physical examination by the study doctor and a detailed neurological exam by a neuro-oncologist; sampling of cerebrospinal fluid (CSF) by lumbar puncture; review of current medications; measurement of vital signs; check on the patients ability to perform daily activities; blood work ...
The Scottish Medicines Consortium (SMC) has today recommended the use of liposomal cytarabine with daunorubicin to treat previously untreated therapy-related AML (t-AML) and AML with myelodysplastic changes (AML-MRC).
JENKINTOWN, Pa., October 23, 2007 - The National Comprehensive Cancer Network (NCCN) announces important updates to the NCCN Central Nervous System (CNS) Cancers Guidelines. The NCCN Clinical Practice Guidelines in Oncology™ are widely recognized and applied as the standard of care in oncology in the United States in both the community and the academic practice settings. The NCCN CNS panel revised the guidelines by providing radiation therapy dosing and new detailed recommendations for chemotherapy for specific brain cancers or metastatic sites. For example, patients with recurrent CNS metastases from breast cancer, CNS lymphoma, or carcinomatous/lymphomatous meningitis can be treated with a high-dose methotrexate regimen.. The NCCN CNS guidelines now include specific recommendations for brain imaging. These imaging results are used mainly to make treatment decisions. The most common use is to differentiate radiation necrosis from active tumor, which may prevent unnecessary surgery or other ...
Leptomeningeal carcinomatosis is a rare entity caused by metastases from solid tumors in the form of diffuse seeding to the leptomeninges. Lots of neurologic symptoms related to cerebrum, cerebellum, spinal root, and cranial nerves can be occurred in leptomeningeal carcinomatosis patients. It is not often that only bilateral hearing loss is present as the initial clinical symptom. In this report, we present a 54-year-old man represented with sudden bilateral hearing loss and vertigo who were operated for duodenal adenocarcinoma six months before. The clinical, radiologic, and cerebrospinal fluid cytologic features of the patient and the case reports of sudden hearing loss related to leptomeningeal carcinomatosis are discussed. ...
A 67-year-old woman with metastatic carcinoid tumor developed neurologic signs and symptoms of left facial paralysis and progressive lower extremity weakness. Results of cytologic evaluation of cerebrospinal fluid were normal. However, biochemical analysis of the cerebrospinal fluid showed extreme elevations of 5-hydroxyindoleacetic acid and serotonin, consistent with carcinomatous meningitis caused by carcinoid tumor. Subsequent contrast myelography confirmed the presence of meningeal metastases. ...
Arachnoiditis paresthesias prostate cancer - Leptomeningeal carcinomatosis (LC) - About Cancer. Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function.
Leptomeningeal metastases from recurrent squamous cell cancer of the skin.: We report two patients with leptomeningeal metastases from squamous cell cancer of t
Methotrexate (MTX)-associated myelopathy is a rare but serious subacute complication of MTX-based chemotherapy. We report the case of a woman with breast cancer and meningeal carcinomatosis who developed severe progressive myelopathy after four cycles of intrathecal MTX administration. We substituted high doses of the key metabolites of the methyl-transfer pathway: S-adenosylmethionine (SAM), 200 mg three times daily i.v.; folinate, 20 mg four times daily i.v.; cyanocobalamin, 100 mug once daily i.v.; and methionine, 5 g daily p.o. The patients paraparesis improved rapidly thereafter, and magnetic resonance (MR) imaging showed resolution of the intramedullary lesions. Genetic analyses revealed homozygosity for the A allele of methylenetetrahydrofolate reductase (MTHFR) c.1298A,C (p.E429A), whereas other genetic variants of folate/methionine metabolism associated with MTX neurotoxicity were not present. Substitution with multiple folate metabolites may be a promising strategy for the treatment ...
Objective: Correlate imaging and survival in a retrospective series of patients with leptomeningeal metastasis (LM). Methods: 240 patients with LM (125 solid tumour patients with positive CSF cytology; 40 solid tumour patients with negative CSF cytology and MRI consistent with LM; 50 lymphoma and 25 leukaemia patients with positive CSF flow cytometry), all considered for treatment, underwent prior to treatment neuraxis MRI and radio-isotope CSF flow studies. Results: Survival was significantly shortened in patients with large volume MRI-defined disease and in patients with CSF flow obstruction irrespective of primary tumour histology. Additionally, cause of death differed wherein patients with large volume of disease or obstructed CSF flow more often died of progressive LM disease. Conclusions: Neuraxis imaging utilizing brain and spine MRI as well as radio-isotope CSF flow studies has prognostic significance and is predictive of median overall survival in this large cohort of patients all ...
Chamberlain MC, Glantz M, Groves MD, Wilson WH. Diagnostic tools for neoplastic meningitis: detecting disease, identifying patient risk, and determining benefit of treatment. Semin Oncol. 2009; 36 (4 Suppl 2):S35-45 ...
TY - JOUR. T1 - Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. AU - Koh, Susan. AU - Nelson, Marvin D.. AU - Kovanlikaya, Arzu. AU - Chen, Lan. PY - 1999. Y1 - 1999. N2 - Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children. Progressive paraplegia, one of the devastating neurologic complications related to this mode of treatment, has been attributed to spinal cord toxicity. Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery. Gadolinium enhancement of anterior lumbosacral spinal nerve roots was demonstrated in all three patients, and an elevation of cerebrospinal fluid immunoglobulin G synthesis was evident in two patients with more severe symptoms. The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic ...
Helical tomotherapy in patients with leptomeningeal metastases Sanziana RI Schiopu,1,2 Gregor Habl,3 Matthias Haefner,2 Sonja Katayama,2 Klaus Herfarth,2,4 Juergen Debus,2,4 Florian Sterzing4,5 1Department of Internal Medicine V, Ludwig-Maximilian University, Munich, Germany; 2Department of Radiation Oncology, Heidelberg University, Heidelberg, Germany; 3Department of Radiation Oncology, Klinikum rechts der Isar, Technical University, Munich, Germany; 4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 5Radiation Oncology, Kempten Clinic, Kempten, Germany Purpose: Leptomeningeal metastasis (LM) is an increasingly common complication of late-stage systemic cancer, for which there is no standard treatment. We analyzed outcome and toxicity in patients with LM undergoing craniospinal irradiation via helical tomotherapy (HT-CSI) at our institution. Patients and methods: The charts of 15 patients diagnosed with LM and undergoing HT-CSI between 2006 and
TY - JOUR. T1 - Comparison of motor conduction abnormalities in lumbosacral radiculopathy and axonal polyneuropathy. AU - Berger, Alan R.. AU - Sharma, Khema. AU - Lipton, Richard B.. PY - 1999/8. Y1 - 1999/8. N2 - We compared the frequencies and types of motor conduction abnormalities found in peroneal and tibial nerves of patients with either L5/S1 radiculopathies (n = 47) or axonal polyneuropathies (n = 49). In axonal neuropathies, compound muscle action potentials (CMAPs) were more likely to be either unobtainable or, if present, of low amplitude, prolonged in distal latency or both. F responses were more often absent, impersistent, or prolonged in minimal latency. In contrast, CMAPs in lumbosacral radiculopathies were more likely to be normal in both amplitude and distal latency. The most frequent F-response abnormality in radiculopathies was a prolonged maximum-minimum latency range rather than abnormalities of minimal latency or persistence. Logistic regression analysis demonstrated that ...
The Scientific World Journal is a peer-reviewed, Open Access journal that publishes original research, reviews, and clinical studies covering a wide range of subjects in science, technology, and medicine. The journal is divided into 81 subject areas.
Find the best intrathecal chemotherapy doctors in Delhi NCR. Get guidance from medical experts to select intrathecal chemotherapy specialist in Delhi NCR from trusted hospitals - credihealth.com
Metastases spread to the nervous system through the bloodstream cerebral, spinal, and leptomeningeal metastases , lymphatic vessels metastases to the PNS , and
Journal of Drug Delivery is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of therapeutic delivery and targeting. The journal serves researchers from academia and industry, and will publish articles ranging from basic biology of drug and gene delivery through to application and development of these principles. Articles describing drug dosage forms will be considered.
most widely lumbosacral radiculopathy.It has features that are similar to those related diseases.Lumbar sciatica proceeds chronically.His often aggravate acute relapses.Torso and started walking, patients experience pain amplification.. localization of lesions caused by an area of ​​innervation.Concentration of pain depends on the focus of inflammation.Patients feel it in the area of ​​the lumbar and gluteal region, hip, his posterolateral and anterior zone perednenaruzhnoy calf.Pain pierces the rear of the foot passes through the heel of the thumb touches the calf muscle and is found in the outer ankle.. Soreness strongly expressed when the roots are compressed bony outgrowths, CDs, various dense fabric, for example, formed an intervertebral hernia.The pain caused by soft tissues (muscles, ligaments), holding the nerves are not as powerful.It is characterized by mild dynamics of growth.. provoke radiculopathy of lumbosacral spine is usually destructive processes in the ligaments, ...
TY - JOUR. T1 - Office laparoscopy and biopsy for evaluation of patients with intraperitoneal carcinomatosis using a new optical catheter. AU - Childers, Joel M.. AU - Hatch, Kenneth D. AU - Surwit, Earl A.. PY - 1992. Y1 - 1992. N2 - We report seven patients who underwent diagnostic laparoscopy and biopsy under local anesthesia using a new optical catheter. Six of these procedures were performed in the office. Four patients had previous malignancies (lung, breast, and fallopian tube), and intraperitoneal recurrences or new primaries were suspected. In two of these patients, laparoscopically directed biopsies confirmed adenocarcinoma similar to their prior malignancies, and in one a new primary was diagnosed. The fourth patient had no evidence of intraperitoneal disease. In the three patients with new intraperitoneal malignancies, biopsies obtained laparoscopically confirmed adenocarcinomas of the ovary in two patients and of the gastrointestinal tract in one patient. We feel that this procedure ...
Delirium in the Setting of Metastatic Cancer (present in 20-86% of cases; reversible in ~50%) Metabolic Abnormalities hypercalcemia hyperglycemia hyponatremia/hypernatremia uremia hepatic failure others Hypoxia Medications opiates benzodiazepines corticosteroids many others Infections Brain/Leptomeningeal Metastases Bowel/Bladder Obstruction Others
The patient had a history of lung cancer and went on to have large volume CSF. Cytology Cell block preparation of CSF Malignant cells present Strongly positive for pan-keratin on immunohistochemistry (and negative for CD20 and CD3) Diagnost...
The inspection was conducted by the UK and French medicines regulatory agencies in July 2012. DepoCyte has been authorised in the European Union since 11 July 2001 and is marketed in Austria, Belgium, Bulgaria, the Czech Republic, Denmark, Finland, France, Germany, Ireland, Italy, the Netherlands, Poland, Romania, Slovakia, Slovenia, Spain, Sweden and the United Kingdom, as well as Iceland and Norway. Lymphomatous meningitis is a condition in which cells from a lymphoma (a tumour in the lymphatic system) have spread to the spinal fluid and the meninges (the membranes that surround the brain and spinal cord). Therapeutic alternatives include medicines containing non-liposomal cytarabine, methotrexate or thiotepa. It should be noted that not all alternative products are approved for intrathecal use. For further information on indications and posology of alternative treatments, the product information should be consulted ...
Neurologic complications occur frequently in patients with cancer. After routine chemotherapy, these complications are the most common reason for hospitalization of these patients. Brain metastases are the most prevalent complication, affecting 20 to 40 percent of cancer patients and typically presenting as headache, altered mental status or focal weakness. Other common metastatic complications are epidural spinal cord compression and leptomeningeal metastases. Cord compression can be a medical emergency, and the rapid institution of high-dose corticosteroid therapy, radiation therapy or surgical decompression is often necessary to preserve neurologic function. Leptomeningeal metastases should be suspected when a patient presents with neurologic dysfunction in more than one site. Metabolic encephalopathy is the common nonmetastatic cause of altered mental status in cancer patients. Cerebrovascular complications such as stroke or hemorrhage can occur in a variety of tumor-related conditions, including
TY - JOUR. T1 - Could texture features from preoperative ct image be used for predicting occult peritoneal carcinomatosis in patients with advanced gastric cancer?. AU - Kim, Hae Young. AU - Kim, Young Hoon. AU - Yun, Gabin. AU - Chang, Won. AU - Lee, Yoon Jin. AU - Kim, Bohyoung. PY - 2018/3. Y1 - 2018/3. N2 - Purpose To retrospectively investigate whether texture features obtained from preoperative CT images of advanced gastric cancer (AGC) patients could be used for the prediction of occult peritoneal carcinomatosis (PC) detected during operation. Materials and methods 51 AGC patients with occult PC detected during operation from January 2009 to December 2012 were included as occult PC group. For the control group, other 51 AGC patients without evidence of distant metastasis including PC, and whose clinical T and N stage could be matched to those of the patients of the occult PC group, were selected from the period of January 2011 to July 2012. Each group was divided into test (n = 41) and ...
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ABSTRACT Leptomeningeal Metastases LM is a condition in which tumor cells from a primary tumor metastasize invade the subarachnoid space SAS and spread throughout the cerebrospinal fluid CSF resulting in seeding along the meninges brain and spinal cord LM represents a devastating event of cancer progression There are cases annually and currently no cure with average survival of months with current .... ...
1. The primary objectives of this study are: 1. To determine the tolerability of RTA 744 Injection in patients with leptomeningeal
The purpose of this work was to describe the human leptomeningeal and cortical vascular anatomy as seen at high resolution on an 8 T UHFMRI system. With a 1024 x 1024 matrix, axial gradient echo images of the cerebral cortex were acquired on a human volunteer at 8 T with TR 500 ms, TE 1...read more ...