Whether respiratory epithelial cells regulate the final transit of extravasated neutrophils into the inflamed airspace or are a passive barrier is poorly understood. Alveolar epithelial type 1 (AT1) cells, best known for solute transport and gas exchange, have few established immune roles. Epithelial membrane protein 2 (EMP2), a tetraspan protein that promotes recruitment of integrins to lipid rafts, is highly expressed in AT1 cells but has no known function in lung biology. Here, we show that Emp2-/- mice exhibit reduced neutrophil influx into the airspace after a wide range of inhaled exposures. During bacterial pneumonia, Emp2-/- mice had attenuated neutrophilic lung injury and improved survival. Bone marrow chimeras, intravital neutrophil labeling, and in vitro assays suggested that defective transepithelial migration of neutrophils into the alveolar lumen occurs in Emp2-/- lungs. Emp2-/- AT1 cells had dysregulated surface display of multiple adhesion molecules, associated with reduced raft ...
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Podoplanin is a type I integral membrane glycoprotein with diverse tissue distribution, expressed at high levels in lung, placenta, and skeletal muscle. In humans, it is encoded by the PDPN gene. The exact function of podoplanin is unknown, but it is thought to be involved in cell migration, motility, and adhesion. Podoplanin is required for normal lung cell proliferation and alveolus formation at birth, and has been proposed as a marker for lung injury. Podoplanin is also known as lung type I cell membrane associated glycoprotein, glycoprotein 36 (GP36), GP38, GP40, T1-alpha, T1A, T1A-2, OTS8, AGGRUS, HT1A-1, and PA2.26.. ...
There are different subpopulations of Th17 cells that can express either a regulatory or inflammatory gene signature depending on their exposure to pathogens, cytokines, and other environmental factors such as sodium chloride. Podoplanin is a type I transmembrane glycoprotein proposed to regulate T cells in mouse models of Th17 inflammation. Here, we demonstrate that induction of podoplanin expression drives a more immunosuppressive regulatory T cell program with loss of IL-17 secretion in human CD4+ cells. Ligation of PDPN by its ligand CLEC-2 on CD4+ cells induced under Th17 conditions ameliorates the Th17 inflammatory response. Moreover, under proinflammatory, high NaCl conditions, PDPN expression is reduced via an Sgk1-mediated pathway. Finally, IL-17 secretion is restored with shRNA gene silencing of PDPN. Clinically, CD3+PDPN+ T cells are devoid of IL-17 in skin biopsies from patients with candidiasis, a Th17-driven skin disease. Thus, PDPN expression identifies a nonpathogenic Th17 ...
The history of cell culture dates back to 1907 when Ross Harrison discovered that neuronal cells could be cultured in vitro. Two types of cells used within cell culture include primary and established cell lines. Among established cells HEK 293 and 293T cells are among the most widely used in the technique of cell culture. Lymphatic endothelial cells (LECs) are often represented as primary cells, which have been isolated from tissues. Previous studies have characterized 293 and 293T cells as neuronal in origin although phenotypic analyses have not been reported. Similarly, studies dealing with the binding characteristics of HIV have revealed the expression of podoplanin, a typical LEC marker, by 293T cells. Additionally, our lab has observed the expression of podoplanin by 293 cells through flow cytometry analysis. These observations of podoplanin expression suggest that the phenotype of 293 and 293T cells needs to be further explored and that they might resemble LECs. This study outlines the ...
CD277 (known as BT3.1, BTN3A1, BTF5) is a 56 kD type I transmembrane glycoprotein. It is one of the three (BT3.1, BT3.2, and BT3.3) BT3 subfamily members. BT3 belongs to butyrophilin (BT)/B7 family and Ig superfamily. BT3.1 is expressed by T cells, B cells, monocytes, NK cells, dendritic cells, subset of stem cells, endothelial cells and some tumor cells. It has been proposed to regulate T cell activation through interaction with its counter-receptor (BT3.1-R ...
Shop P-selectin glycoprotein ligand ELISA Kit, Recombinant Protein and P-selectin glycoprotein ligand Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Liang, W and Cohen, E P., "Detection of thymus leukemia antigens on the surface membranes of murine leukemia cells resistant to thymus leukemia anti- bodies and guinea pig complement." (1977). Subject Strain Bibliography 1977. 2311 ...
EMP-2 belongs to the peripheral myelin protein 22 (PMP22) family (together with EMP-1 and EMP-3), which are tetraspan transmembrane proteins.. It plays an important role in blastocyst implantation with the uterine endometrium. It plays a role in female reproductive cancers. ...
Human CellExp Osteoactivin / GPNMB, human recombinant protein, GPNMB, HGFIN, NMB, Osteoactivin validated in (PBV11132r-10), Abgent
Myc-DDK-tagged ORF clone of Homo sapiens butyrophilin, subfamily 3, member A3 (BTN3A3), transcript variant 1 as transfection-ready DNA - 10 µg - OriGene - cdna clones
Hourani, B T.; Chace, N M.; and Pincus, J H., "Isolation of membrane glycoproteins from l1210 cells with lectin receptor activities. Abstr." (1973). Subject Strain Bibliography 1973. 653 ...
package Organism; use strict; use warnings; use feature state; sub count { return scalar keys %{ shift-,{Cells} }; } # Input a list of [ x, y ] coords sub insert_cells { my $cells = shift-,{Cells}; for my $r (@_) { $cells-,{ pack ii, @{$r} } = undef } } # Return sorted list of cells in the Organism. # Used for verification and testing the state of the organism. sub get_live_cells { sort { $a-,[0] ,=, $b-,[0] ,, $a-,[1] ,=, $b-,[1] } map { [ unpack ii, $_ ] } keys %{ shift-,{Cells} }; } # Return the list of dead cells surrounding a cell sub get_dead_cells { my ( $cells, $x0, $y0 ) = ( shift-,{Cells}, @_ ); my ( $x1, $x2, $y1, $y2 ) = ( $x0 - 1, $x0 + 1, $y0 - 1, $y0 + 1 ); state ( $k1, $k2, $k3, $k4, $k5, $k6, $k7, $k8 ); ( ( $k1 = pack ii, $x1, $y1 ) x !( 0 + exists $cells-,{ $k1 } ), ( $k2 = pack ii, $x1, $y0 ) x !( 0 + exists $cells-,{ $k2 } ), ( $k3 = pack ii, $x1, $y2 ) x !( 0 + exists $cells-,{ $k3 } ), ( $k4 = pack ii, $x0, $y1 ) x !( 0 + exists $cells-,{ $k4 } ), ( $k5 = ...
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Podoplanin (Pdpn) is a type 1 transmembrane mucin-type O-glycoprotein [1, 2]. It consists of 172 amino acids in mice and 163 amino acids in humans. It is expres...
Podoplanin / gp36兔多克隆抗体(ab10274)可与人样本反应并经WB, IP, ICC/IF实验严格验证,被4篇文献引用并得到1个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
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In this study, we show that posttranslational folding of Vesicular Stomatitis virus G protein subunits can involve noncovalent, multimeric complexes as transient intermediates. The complexes are heterogeneous in size (4-21S20,W), contain several G glycopolypeptides, and are associated with BiP/GRP78. The newly synthesized, partially intrachain disulfide-bonded G proteins enter these complexes immediately after chain termination, and are released 1-4 min later as fully oxidized, trimerization-competent monomers. These monomers are properly folded, judging by their binding of conformation-specific mAbs. When the G protein is translated in the presence of DTT, it remains reduced, largely unfolded and aggregated in the ER, but it can fold successfully when the DTT is removed. In this case, contrary to normal folding, the aggregates become transiently disulfide cross-linked. We also demonstrated that the fidelity of the folding process is dependent on metabolic energy. Finally, we established that ...
... ,Interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the earliest rolling of leukocytes on the lumenal surface of endothelial cells at sites of inflammation. To date, the primary role of PSGL-1 in mediating the interaction between neutrophils and P-selectin has bee,biological,biology supply,biology supplies,biology product
The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two major cytolytic pathways mediated by CD8+ cytolytic T cells. To gain further understanding of the Fas system., we have analyzed Fas and FasL expression during mouse development and in adult tissues. In developing mouse embryos, from 16.5 d onwards, Fas mRNA is detectable in distinct cell types of the developing sinus, thymus, lung, and liver, whereas FasL expression is restricted to submaxillary gland epithelial cells and the developing nervous system. Significant Fas and FasL expression were observed in several nonlymphoid cell types during embryogenesis, and generally Fas and FasL expression were not localized to characteristic sites of programmed cell death. In the adult mouse, RNase protection analysis revealed very wide expression of both Fas and FasL. ...
The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two major cytolytic pathways mediated by CD8+ cytolytic T cells. To gain further understanding of the Fas system., we have analyzed Fas and FasL expression during mouse development and in adult tissues. In developing mouse embryos, from 16.5 d onwards, Fas mRNA is detectable in distinct cell types of the developing sinus, thymus, lung, and liver, whereas FasL expression is restricted to submaxillary gland epithelial cells and the developing nervous system. Significant Fas and FasL expression were observed in several nonlymphoid cell types during embryogenesis, and generally Fas and FasL expression were not localized to characteristic sites of programmed cell death. In the adult mouse, RNase protection analysis revealed very wide expression of both Fas and FasL. ...
Wael Haddad, Cristine J. Cooper, Zheng Zhang, Jeffrey B. Brown, Yuechun Zhu, Andrew Issekutz, Ivan Fuss, Hae-ock Lee, Geoffrey S. Kansas, Terrence A. Barrett ...
Mokkapati, Sharada (2007) Role of the Basement Membrane Proteins Nidogen-1 and -2 and Laminin-Nidogen Interaction in Physiology and Pathology of Skin. [Thesis Abstract]. ...
The 65-kDa protein (p65) was previously identified as a phosphorylated protein in activated macrophages, and has turned out to be a member of a plastin protein family characterized by a series of Ca,SUP,2+,/SUP,-, calmodulin-, and β-actin-binding domains. In mice, two isoforms, p65/L-plastin and T-plastin, have so far been identified; p65/L-plastin is expressed in hemopoietic cells and cancer cells, and T-plastin in solid tissue cells. We generated monoclonal antibodies to p65/L-plastin, examined the isoform-specificity by using recombinant (r) T-plastin, and found that the antibodies were specific for rp65/L-plastin, whereas immune sera to rp65/L-plastin showed cross-reactions to rT-plastin. One of the antibodies, p65-7B5, was demonstrated to react to native p65/L-plastin by Western blot, flow cytometric, and immunohistochemical analysis. Furthermore, p65-7B5 has made it possible to detect p65/L-plastin-expressing cells in tissues where T-plastin is abundantly expressed. These reagents and ...
Modulation of FasL expression in HT29 and RHT29 cells lines.FasL expression was detected in HT29 and RHT29 cell lines treated or not with oxaliplatin 10 µM by
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The restricted host-cell range and low titer of retroviral vectors limit their use for stable gene transfer in eukaryotic cells. To overcome these limitations, we have produced murine leukemia virus-derived vectors in which the retroviral envelope glycoprotein has been completely replaced by the G glycoprotein of vesicular stomatitis virus. Such vectors can be concentrated by ultracentrifugation to titers , 10(9) colony-forming units/ml and can infect cells, such as hamster and fish cell lines, that are ordinarily resistant to infection with vectors containing the retroviral envelope protein. The ability to concentrate vesicular stomatitis virus G glycoprotein pseudotyped vectors will facilitate gene therapy model studies and other gene transfer experiments that require direct delivery of vectors in vivo. The availability of these pseudotyped vectors will also facilitate genetic studies in nonmammalian species, including the important zebrafish developmental system, through the efficient ...
Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a fatal disorder. Currently treatment is symptomatic. Thus, there is a real need to intervene and slow the progression of this disease. Preliminary data on genetic knock-down of the ability to mount an immune response in cln3-knockout mice is supportive of a strategy for treating JNCL with an immuno-suppressive agent. Many drugs with the ability to suppress the immune system are steroidal and deemed unsuitable for long-term administration to children. Mycophenolate mofetil (CellCept) is used as an immunosuppressive agent in allogenic transplants in pediatric patients and is therefore approved by the Food and Drug Administration (FDA) for pediatric use.. The study design is a double-blind, randomized, 22-week cross-over study of mycophenolate mofetil vs. placebo. After a 4-week washout period, subjects will undergo blinded crossover from active study drug to placebo or from placebo to active study drug.. Subjects and caregivers will be evaluated ...
Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) is a fatal disorder. Currently treatment is symptomatic. Thus, there is a real need to intervene and slow the progression of this disease. Preliminary data on genetic knock-down of the ability to mount an immune response in cln3-knockout mice is supportive of a strategy for treating JNCL with an immuno-suppressive agent. Many drugs with the ability to suppress the immune system are steroidal and deemed unsuitable for long-term administration to children. Mycophenolate mofetil (CellCept) is used as an immunosuppressive agent in allogenic transplants in pediatric patients and is therefore approved by the Food and Drug Administration (FDA) for pediatric use.. The study design is a double-blind, randomized, 22-week cross-over study of mycophenolate mofetil vs. placebo. After a 4-week washout period, subjects will undergo blinded crossover from active study drug to placebo or from placebo to active study drug.. Subjects and caregivers will be evaluated ...
TY - JOUR. T1 - Vesicular stomatitis virus glycoprotein contains a dominant cytoplasmic basolateral sorting signal critically dependent upon a tyrosine. AU - Thomas, DNette C.. AU - Brewer, Colleen B.. AU - Roth, Michael G.. PY - 1993/1/1. Y1 - 1993/1/1. N2 - To investigate the contribution of the cytoplasmic domain of the vesicular stomatitis virus G glycoprotein to its basolateral expression in polarized epithelial cells, chimeric proteins containing the external and transmembrane domains of an apically targeted protein, the influenza virus hemagglutinin (HA), and either the G cytoplasmic domain or an unrelated cytoplasmic sequence, were introduced into Madin-Darby canine kidney (MDCK) cells. Addition of the cytoplasmic tail of G to a truncated HA resulted in delivery of greater than 95% of the chimeric protein to the basolateral cell surface, indicating that the G cytoplasmic domain contains a dominant basolateral sorting signal. A similar chimera, containing the cytoplasmic tail of herpes ...
Clinical trial for Pleural Effusion , Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion
NEW YORK, NY and CLEVELAND, OH--(Marketwired - March 02, 2016) - AB0-201 (AAV CLN3) demonstrates promising in vivo efficacy in preclinical models IND enabling toxicology to commence in 2016 Abeona Therapeutics,…
The report on the Global T Cell Surface Glycoprotein CD3 Epsilon Chain market offers complete data on the T Cell Surface Glycoprotein CD3 Epsilon Chain market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the T Cell Surface Glycoprotein CD3 Epsilon Chain market. The top contenders Amgen Inc, Celgene Corp, F. Hoffmann-La Roche Ltd, GlaxoSmithKline Plc, MacroGenics Inc, Meridigen Biotech Co Ltd, Numab Innovation AG, SYNIMMUNE GmbH, Tiziana Life Sciences Plc of the global T Cell Surface Glycoprotein CD3 Epsilon Chain market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=20413. The report also segments the global T Cell Surface Glycoprotein CD3 Epsilon Chain market based on product mode and ...
The cDNA sequence of mouse LAMP 2: evidence for two classes of lysosomal membrane glycoproteins is an eagle-i resource of type Journal article at eagle-i Network Shared Resource Repository.
Blocking the Fas/FasL interaction in vivo rescues isotype-switched B cells in μMT mice. A neutralizing recombinant FasIg protein was purified and engineered in
A stable cell line expressing a complementary DNA clone encoding the vesicular stomatitis virus glycoprotein fused and formed polykaryons at pH 5.5. The formation of polykaryons was dependent on the presence of glycoprotein anchored at the cell surface and could be prevented by incubation of cells with a monoclonal antibody to the glycoprotein. Fusion occurred at a pH 0.5 unit lower than that observed for cells infected with vesicular stomatitis virus. ...
Definition of Counter-attacks in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Counter-attacks? Meaning of Counter-attacks as a legal term. What does Counter-attacks mean in law?
In contrast to apoptosis induced by some anticancer drugs as well as other stimuli, such as UV irradiation, anti-CD3 stimulation, and mitogen treatment (54, 55, 56, 57, 58, 59), Tet induced T cell apoptosis through a mechanism independent of Fas/FasL interaction. This conclusion was supported by several observations. First, the expression of Fas/FasL mRNA was not enhanced by Tet treatment (our unpublished observations). Second, Tet did not increase Fas/FasL expression on the T cell surface (Fig. 5⇑). Third, both Fas-sensitive and Fas-resistant T cells showed comparable susceptibility to Tet-induced apoptosis (Fig. 6⇑). Lastly, Tet-induced activation of caspase-3 appeared to have similar kinetics and intensity in Fas-sensitive and Fas-resistant T cells (Fig. 8⇑). This observation suggests that Tet can activate the T cell death machinery without the participation of cell surface Fas/FasL molecules. Treatment with Tet might be useful in autoimmune disorders caused by mutations in Fas or FasL ...
Preclinical data suggests both the delivery and the therapy are working, so far.. "This is the first demonstration of a systemic delivery route to restore CLN3 in vivo," using the specially-engineered virus, concludes a study published by Dr. Kielian and her collaborators in a recent edition of The Journal of Neuroscience.. CLN3 is the gene that shows a mutation in juvenile Batten disease. Also known as juvenile neuronal ceroid lipofuscinosis, the disease is an inherited, autosomal recessive, fatal neurodegenerative disorder.. Juvenile Batten disease occurs in children, and is often first noticeable between ages 5 and 10. The first symptom is vision loss, followed by seizures, cognitive loss and motor decline. Finally, premature death. There are no therapeutics or cure.. Its a rare but devastating disease.. But Dr. Kielians research shows, in an animal model, that the virus is an effective delivery system. It spreads through the body, even crossing the blood-brain barrier, from a single ...
The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity. Proteolytic cleavage leads to the generation of membrane-bound N-terminal fragments and a soluble FasL (sFasL) ectodomain. sFasL can be detected in the serum of patients with dysregulated inflammatory diseases and is discussed to affect Fas-FasL-mediated apoptosis. Using pharmacological approaches in 293T cells, in vitro cleavage assays as well as loss and gain of function studies in murine embryonic fibroblasts (MEFs), we demonstrate that the disintegrin and metalloprotease ADAM10 is critically involved in the shedding of FasL. In primary human T cells, FasL shedding is significantly reduced after inhibition of ADAM10. The resulting elevated FasL surface expression is associated with increased killing capacity and an increase of T cells undergoing AICD. Overall, our findings ...
Juvenile Batten disease was named after Frederick Batten, MA, MD, FRCP, when he reported on two sisters with the disease in 1903. 1, 2 As various forms of Batten were discovered, each was named according to its age of onset (Classic forms of Batten). This was very simple when there were only four known forms [infantile, late infantile, juvenile and adult]. However, several variant late forms were discovered complicating the matter. It wasnt until the first genes associated with Batten disease were discovered that researchers learned that different mistakes in the same gene can result the same disease with various ages of onset. 4, 6 In other words, mistakes in the CLN1 gene can cause disease beginning in the infantile, late infantile, juvenile or adult periods (CLN Gene Defects).. Juvenile Batten disease, the focus of Beyond Batten Disease Foundation, is also called CLN3 disease. Children with CLN3 disease almost always develop symptoms in the juvenile period.5. ...
F. Carrouel, M. J Staquet, J. F Keller, C. Baudouin, P. Msika, F. Bleicher, B. Alliot-Licht, and J. C Farges (2013) J Endod, 39(8):1008-14.. ...
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LBP [LPS (lipopolysaccharide)-binding protein] was discovered approximately 25 years ago. Since then, substantial progress has been made towards our understanding of its function in health and disease. Furthermore, the discovery of a large protein family sharing functional and structural attributes has helped in our knowledge. Still, key questions are unresolved, and here an overview on the old and new findings on LBP is given. LBP is an acute-phase protein of the liver, but is also synthesized in other cells of the organism. While LBP is named after the ability to bind to LPS of Gram-negative bacteria, it also can recognize other bacterial compounds, such as lipopeptides. It has been shown that LBP is needed to combat infections; however, the main mechanism of action is still not clear. New findings on natural genetic variations of LBP leading to functional consequences may help in further elucidating the mechanism of LBP and its role in innate immunity and disease. ...
Fas Ligand antibody [MFL4] (Fas ligand (TNF superfamily, member 6)) for FACS. Anti-Fas Ligand mAb (GTX42337) is tested in Mouse, Rat samples. 100% Ab-Assurance.
Es wird angenommen, dass an der Ätiologie der Multiplen Sklerose (MS) Umweltfaktoren beteiligt sind, die die Selbst-Toleranz gegen Auto-Antigene innerhalb des Myelins unterbrechen. Die Identität und Wirkungsweise dieser Umweltfaktoren sind aber unbekannt. Das Myelin-Oligodendrozyten-Protein (MOG) ist ein mögliches, wichtiges Auto-Antigen in der MS. Diese Arbeit zeigt, dass die Epitopspezifität von Auto-Antikörpern gegen MOG heterogen ist. Weiter wird gezeigt, dass MOG eine umfassende, immunologische Kreuzreaktivität mit dem bovinen Milch-Protein Butyrophilin (BTN) aufweist, einem ubiquitären, diätetischen Antigen. In einer Untergruppe von MS-Patienten ist diese kreuzreaktive Antikörper-Antwort signifikant erhöht und selektiv im zentralen Nervensystem (ZNS) sequestriert. Dieses Ergebnis weist darauf hin, dass diese kreuzreaktive Auto-Immunantwort eine aktive Rolle in der Pathogenese der MS spielen könnte. Möglicherweise moduliert immunologische Kreuzreaktivität zwischen MOG und BTN ...
Human Perforin ELISA Kit (5 plate). The U-CyTech sandwich ELISA kits have been developed for cytokine determinations in culture supernatant, serum and plasma. The kit is supplied with all necessary reagents to perform 480 ELISA determinations. Cytokines are a group of regulatory proteins critically involved in many physiological processes such as immune recognition, cell differentiation and cell proliferation. They have been identified in many vertebrate species and are produced by a variety of different cell types. Cytokines are usually produced transiently and locally, acting in a paracrine or autocrine manner. They interact with high affinity cell surface receptors specific for each cytokine or cytokine group and are active at very low concentrations mostly in the picogram range. It is well known now that the type of an antigen-specific immune response largely depends on the selection or preferential activation of defined CDM|sub|4|sup|+ T cell subsets (i.e. Th1 and Th2). Activation of these subsets
Batten disease is inherited in an autosomal recessive fashion, meaning a child needs to inherit one copy of the defective gene for the condition form each of their parents in order to develop the disease.
References for Abcams Anti-Fas Ligand antibody [B-R17] (ab47174). Please let us know if you have used this product in your publication