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Purpose : To compare attitudes and practices related to clinicians use of depot medroxyprogesterone acetate Depo-Provera DMPA and levonorgestrel implants in adolescents in three northern European countries and the United States. Methods : Between the fall of 1993 and the winter of 1995, surveys eliciting clinician attitudes and practices with...
In the United States, depot medroxyprogesterone acetate (DMPA) is given to women after delivery and before hospital discharge with the belief that women who delay starting DMPA may be more likely to become pregnant when they are not yet ready to be pregnant and that giving DMPA before discharge has little to no negative effect on breastfeeding. Administering DMPA to breastfeeding women has not been widely questioned because the limited existing studies do not show any adverse impact of DMPA on breastfeeding. However, these studies used inappropriate control groups and did not control for prior lactation experience.. The investigators plan to enroll 184 women who are planning to breastfeed and use DMPA after delivery to find out whether the timing of postpartum administration of DMPA (prior to hospital discharge or 4-6 weeks after delivery) affects the duration or exclusivity of breastfeeding among women who plan to breastfeed their infants. The investigators will also look at rates of use of ...
Background & aim: Sexual health is an essential element of quality of life, affecting both physical and psychological domains. Hormones used in contraceptive methods have contradictory effects on sexual function. In this study, we aimed to compare sexual function in women using combined oral contraceptives (COC) and depot medroxyprogesterone acetate (DMPA), referred to healthcare centers affiliated to Shahid Beheshti University of Medical Sciences in Tehran, Iran in 2013. Methods: This descriptive, comparative study was performed on 240 women (n=120 per group), selected through multistage sampling in Tehran, Iran. A questionnaire consisting of three parts, General Health Questionnaire (GHQ-28), demographic characteristics, and Female Sexual Function Index (FSFI), was completed through interviews. For data analysis, descriptive statistics were calculated, and independent t-test, Mann-Whitney test, Chi-square, and Fishers exact test were performed, using SPPS version 16. P-value less than 0.05 was
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2015 Global Medroxyprogesterone Acetate Industry Report is a professional and in-depth research report on the worlds major regional market conditions of the Medroxyprogesterone Acetate industry, focusing on the main regions (North America, Europe and Asia) and the main countries (United States, Germany, Japan and China).
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Depo-Provera (Medroxyprogesterone Acetate) is a hormone injection containing Medroxyprogesterone that lasts for 3 months to prevent pregnancy. The injection has synthetic progesterone and no estrogen.
The injectable progestin contraceptive depot medroxyprogesterone acetate (DMPA) may raise the risk for HIV infection by 40% in women, according to a research review.. DMPA is the major form of hormonal contraceptive used in sub-Saharan Africa, which also has the highest worldwide HIV prevalence, particularly in young women, Healio reports the researchers noted in the review. Other forms of contraception, including combined oral contraceptives containing levonorgestrel or the injectable contraceptive norethisterone enanthate, were not associated with increased HIV infection risk, they wrote.. "Medroxyprogesterone acetate (MPA) used as a highly effective three-monthly injectable contraceptive, Depo-Provera, acts differently to other progestins widely used in contraceptives," Dr Janet P Hapgood, of the department of molecular and cell biology and the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town, South Africa, is quoted in the report as saying. "Available ...
DISCUSSION. We can consider that our population has a differential in relation to other studies evaluating the effect of DMPA, considering that our group was paired with the control group at baseline for BMI (± 1 kg/m2) and age (± 1 year), becoming a homogeneous group. Our study found that after 12 months of follow-up the injectable DMPA users had significant weight gain (3.01 kg). As most prospective studies evaluating the effect of DMPA were for at least 30 months (6,8,9), we can consider that the follow-up period of our study is short compared to the others, but we can already observe significant changes in important variables studied.. To better assess changes in weight and body composition, we made a subdivision of the DMPA group for weight gain (, 3 kg and , 3 kg), and observed significant changes in weight and body composition in both groups, but the group which gained , 3 kg had the more pronounced changes. This group had a mean gain of 5.53 kg, increased fat mass (2.3 kg) and fat-free ...
Expanding contraceptive options through self-injection may improve access and confidentiality. There are few published studies on contraceptive self-injection in sub-Saharan Africa and none in West Africa, a region with high unmet need. This study was performed to assess feasibility of subcutaneous DMPA self-injection in Senegal. These first research results on contraceptive self-injection in West Africa indicate initial feasibility and acceptability of the practice. Results underscore the importance of designing self-injection programs that empower and support women, including those with limited education.. ...
From August 2013 to March 2015, we enrolled 461 participants with pregnancy durations of 75 days or less. Of participants included in the abortion outcome analyses, 14 of 220 (6.4%) and 12 of 226 (5.3%) in the Quickstart and Afterstart groups, respectively, had surgery to complete the abortion; the upper 90% confidence limit on this difference was 4.9%, within our prestipulated 5% noninferiority margin. Ongoing pregnancy after initial abortion treatment was significantly more common in the Quickstart group (8/220 [3.6%]) than in the Afterstart group (2/226 [0.9%]); the difference was 2.7% (90% confidence interval 0.4-5.6%). By 6 months, 5 of 213 (2.3%) and 7 of 217 (3.2%) in the Quickstart and Afterstart groups, respectively, became pregnant (exact log-rank test, P=.64). Use of highly effective contraceptives was significantly more common in the Quickstart group at 31 days (P,.001), but no difference was apparent at 6 months. The Quickstart group was significantly more satisfied with group ...
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Radioimmunoassays for 2 synthetic progestins (Ethinyl-norgestrienone, R 2323 and medroxyprogesterone acetate, MPA) are demonstrated. 10 patients aged 31 to
One-hundred and seventy patients with estrogen receptor positive (≥10 pmol/g protein) advanced breast cancer have been treated in a prospective randomized study either with continuous tamoxifen 30 mg × 1 daily (TAM), or with TAM 30 mg × 1 daily for 8 weeks alternating with medroxyprogesterone acetate 500 mg × 2 daily for 8 weeks (TAM/HD-MPA). The response rate was 62% in the group treated with cyclic TAM/HD-MPA versus 41% in the TAM alone group (p = 0.02). There was no significant difference in duration of remissions or survival.
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Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells. Unlike previous reports with samples from the vagina, we did not observe increased expression of the HIV co-receptor CCR5 on CD4+ T ...
Day S, Graham SM, Masese LN, Richardson BA, Kiarie JN, Jaoko W, Mandaliya K, Chohan V, Overbaugh J, Scott McClelland R. 2014. A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy.. Journal of acquired immune deficiency syndromes (1999). Abstract ...
BACKGROUND Recently published data suggest that hormone replacement therapy (HRT) may increase cardiovascular risk during the early months of therapy. Activation of the immune system is known to be involved in several types of cardiovascular disease. In this cross-sectional study, serum C3, C4, IgG and IgM levels were evaluated in healthy post-menopausal women receiving two different short-term HRT regimens, and in untreated women. METHODS Serum C3, C4, IgM and IgG levels were assessed in 18 women receiving transdermal 17beta-estradiol (50 micro g/day) + continuous oral medroxyprogesterone acetate (MPA; 2.5 mg/day), in 56 women taking oral conjugated equine estrogen (CEE; 0.625 mg/day) + continuous MPA, and in 80 control women not receiving HRT. RESULTS The mean serum C3 level was significantly higher in women using oral CEE + MPA than in women receiving transdermal 17beta-estradiol + MPA, and those not on HRT (P = 0.02 and P | 0.001 respectively). Furthermore, women taking oral CEE + MPA had
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Medroxyprogesterone is a progestin (a form of progesterone), a female hormone that helps regulate ovulation (the release of an egg from an ovary) and menstrual periods. Medroxyprogesterone is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Medroxyprogesterone is also...
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of surgery with or without medroxyprogesterone may be an effective way to prevent the development of endometrial cancer in patients who have endometrial hyperplasia.. PURPOSE: Phase II trial to compare the effectiveness of surgery alone with that of medroxyprogesterone followed by surgery in preventing endometrial cancer in patients who have endometrial hyperplasia. ...
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. MEDROXYPROGESTERONE - ORAL. (meh-DROX-ee-pro-JESS-tur-own) COMMON BRAND NAME(S): Amen, Cycrin, Progestone, Provera WARNING: This medication should not be used during the first 4 months of pregnancy because birth defects may occur. This medication has not been proven to prevent miscarriages that occur early in the pregnancy. Often, the cause of an early miscarriage is due to a defective female egg. Using this drug does not fix a defective egg and may get in the way of expelling it. Two-drug combination hormone replacement therapy (estrogen and progestin menopause HRT) can infrequently cause cancer of the breast, heart disease (e.g., heart attack), stroke, dementia, and ...
Break Through Bleeding (BTB) - vaginal bleeding that requires use of sanitary protection during the time of active hormonal contraception. Combined hormonal contraception (CHC) - hormonal contraception that contains both estrogen and progestin Continuous use - ongoing use of a CHC without a consistently planned hormone-free interval Consult - conferring with a health care provider for information and direction without transferring care DMPA - depot medroxyprogesterone acetate, brand name Depo-Provera™ EC - emergency contraception, 150mg levonorgestrel in a single oral dose if unprotected intercourse occurred in past 5 days, or copper IUD if unprotected intercourse occurred within the past 7 days ECP - emergency contraceptive pill(s) Extended use - using a CHC for two or more cycles without a hormone-free interval with a planned hormonal-free interval Hormone Free Interval (HFI) - the interval in which a client using combined hormonal contraceptives takes either a placebo dose or ≤7 days off, ...
The study performed showed that individuals who had depression were more likely to develop diabetes and vice versa. is sold OTC in 10 mg for regular strength and 20 mg for max strength. And what about second hand smoke? Each color represents a variety of nutrients and vitamins to create a healthy body. Some causes such as diabetes are impossible to reverse and drugs are not the answers for these problems. arthritis can still be an issue ...
The study performed showed that individuals who had depression were more likely to develop diabetes and vice versa. is sold OTC in 10 mg for regular strength and 20 mg for max strength. And what about second hand smoke? Each color represents a variety of nutrients and vitamins to create a healthy body. Some causes such as diabetes are impossible to reverse and drugs are not the answers for these problems. arthritis can still be an issue ...
Background: Depot medroxyprogesterone acetate (DMPA) contraceptive use is associated with an increased risk for Chlamydia infection. However, prior studies inadequately account for potential differences in sexual behavior between users of DMPA and users of other contraceptive methods. In this study we compare sexual risk-taking behavior in women using DMPA to women using oral contraceptive pills (OCP) to assess risk of Chlamydia trachomatis infection. Methods: In this cross-sectional study of 630 reproductive-aged women seeking routine gynecologic care (449 OCP and 181 DMPA users) sexual risk-taking was evaluated by use of the Safe Sex Behavior Questionnaire, a validated measure of sexual behaviors and attitudes ...
Taking a combination form of hormone replacement therapy, which includes both estrogen and progestin, increases a womans risk for dying from lung cancer, a new study has found. The finding stems from an analysis of data from the Womens Health Initiative trial on 16,608 postmenopausal women, aged 50 to 79, in the United States who had been randomly assigned to take either a once-daily tablet of 0.625 milligrams conjugated equine estrogen plus 2.5 mg medroxyprogesterone acetate or a placebo.
Taking a combination form of hormone replacement therapy, which includes both estrogen and progestin, increases a womans risk for dying from lung cancer, a new study has found. The finding stems from an analysis of data from the Womens Health Initiative trial on 16,608 postmenopausal women, aged 50 to 79, in the United States who had been randomly assigned to take either a once-daily tablet of 0.625 milligrams conjugated equine estrogen plus 2.5 mg medroxyprogesterone acetate or a placebo.
This is a clinical study of bone and renal safety with concurrent use of tenofovir (TDF)-based pre-exposure prophylaxis (PrEP) for HIV prevention and depot medroxyprogesterone acetate (DMPA) use for pregnancy prevention. This five-year study will be conducted in Kampala, Uganda and will enroll a prospective cohort of 400 HIV-uninfected young women initiating DMPA and non-hormonal contraception who will all be offered PrEP. Bone health outcomes in women using DMPA and PrEP concurrently will be compared to women using other PrEP/contraceptive combinations. Primary outcomes include assessing the relationship between concurrent use of PrEP and DMPA on bone health including bone mineral density, rates of bone turnover and subclinical kidney injury (precursors to bone loss), and attainment of peak bone mass. ...
Depo-provera (depot Medroxyprogesterone acetate) is an injectable birth control drug that is made of a hormone similar to progesterone.
CONTEXT: Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory. OBJECTIVE: The objective of this study was to determine whether hormone therapy influences changes in specific cognitive functions and affect in older women. DESIGN: This study was a randomized, double-blind, placebo-controlled clinical trial. SETTING: Participants were women from 14 of 40 clinical centers of the Womens Health Initiative (WHI). PARTICIPANTS: Postmenopausal women (1416) aged 65 yr and older, free of probable dementia, and enrolled in WHI and the WHI Memory Study (WHIMS) trial of combination estrogen and progestin for a mean of 3 yr and followed for a mean of 1.35 yr, were studied. INTERVENTION: Intervention was conjugated equine estrogen (CEE; 0.625 mg) with 2.5 mg medroxyprogesterone acetate (MPA) in one daily tablet (CEE + MPA) or placebo. MAIN OUTCOME MEASURES: Annual rates of change in specific cognitive functions and affect, adjusted for time
The new guidelines ignore basic facts about how breastfeeding works," says Dr. Gerald Calnen, President of the Academy of Breastfeeding Medicine (ABM). "Mothers start making milk due to the natural fall in progesterone after birth. An injection of artificial progesterone could completely derail this process.". The CDC report, "U.S. Medical Eligibility Criteria for Contraceptive Use, 2010," released in the May 28 issue of Morbidity & Mortality Weekly Report (MMWR), contains important changes in what constitutes acceptable contraceptive use by breastfeeding women. The criteria advise that by 1 month postpartum the benefits of progesterone contraception (in the form of progestin-only pills, depot medroxyprogesterone acetate (DPMA) injection, or implants), as well as the use of combined (progestin-estrogen) oral contraceptives outweigh the risk of reducing breastfeeding rates. Previously, progesterone birth control was not recommended for nursing mothers until at least 6 weeks after giving birth, ...
Author: Stephenson Kenna, Neuenschwander Pierre F, Kurdowska Anna K, Pinson Barbara, Price Carol, Year: 2008, Abstract: Conventional hormone replacement therapy increases a womans risk of thrombotic events as evidenced in large prospective clinical trials, including HERS I and the Womens Health Initiative. A possible mechanism for this is the unfavorable net effects of conjugated equine estrogens and medroxyprogesterone acetate on factors involved in hemostatic balance and inflammation. The objective of this study was to examine the short-term effects of transdermal progesterone on menopausal symptoms and serum
Medroxyprogesterone. Molecular model of the drug medroxyprogesterone (C22.H32.O3), a chemical that acts as a progestin (synthetic female hormone). It is used to regulate irregular periods in a womans menstrual cycle. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white) and oxygen (red). Illustration. - Stock Image F017/0480
Expression of protein regenerating liver-3 (PRL-3) and VEGF in ovarian epithelial cancer and metastatic site Changes of Body Mass Index and Lipid Profile in Injectable Depot Medroxyprogesterone Acetate and Levonorgestrel Implant Acceptors Comparison of Local and Systemic Interleukin 10 Levels on The Pregnant Women with Bacterial Vaginosis A1298C Polymorphism of Fetal Methylenetetrahydrofolate Reductase (MTHFR) Gene as a Risk Factor for .... Read More » ...
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Hers can refer to: the possessive pronoun version of she two rivers in southern France: Hers-Vif (also: Grand Hers or Hers) Hers-Mort Henri G. Hers, a Belgian scientist The Georgian name for the indigenous people of Hereti, more commonly called Èrs HERS can refer to: Various energy rating systems: Home energy rating system (HERS) in the United States House Energy Rating scheme in Australia Hertwigs epithelial root sheath the Heart and Estrogen/progestin Replacement Study, a clinical study (published in 1998 by S. Hulley, D. Grady, T. Bush et al. in JAMA, 280:605-613) about the secondary prevention, with conjugated equine estrogens and medroxyprogesterone acetate, of documented ischemic cardiomyopathy in ...
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Depo-Provera (DMPA) is an injectable form of hormonal contraception. Depo-Provera is a synthetic form of progesterone called medroxyprogesterone acetate. It primarily works by preventing ovulation and by thickening the cervical mucus to prevent sperm from entering the uterus. Each injection provides protection for 12-13 weeks ...
There was a significant difference between the treated and control ewes in terms of progesterone concentrations after ovulation following MAP treatment in treated ewes. The treated ewes exceeded control ewes in mean serum concentrations of progesterone on Day 4 (1.49 ± 0.33 vs. 1.03 ± 0.22 ng/ml) and Day 5 (2.41 ± 0.29 vs. 1.32 ± 0.25 ng/ml) after ovulation (treated vs. control ewes, respectively, P , 0.05). allergy relief. Serum concentrations of gonadotropins and estradiol. The main effect of group (P = 0.68), day (P = 0.89), and interaction (P = 0.33) were not significant for daily serum concentrations of FSH for the period from 1 day before to 1 day after MAP treatment of treated ewes. Circulating concentrations of estradiol in the ewes of the present study differed by day (P , 0.001), but there was no significant effect of treatment (P = 0.60) and interaction of the main effects was not significant (P = 0.29). Mean daily concentrations of FSH and estradiol did not vary between the two ...
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CAS: 71-58-9 Packing specifications: 25 kg Specification: 99% Molecular formula C24H34O4 Molecular weight of 386.53 Product Name: medroxyprogester