CONCLUSIONS: We compared the novel MLSL method with a binary classification and a rule-based method. The MLSL method performed statistically significantly better than the rule-based method. However, the SVM-based binary classification method was statistically significantly better than the MLSL method for both the CTA and CN corpora. Using parsimonious feature sets both the SVM-based binary classification and CRF-based MLSL methods achieved high performance in detecting medication name and attribute linkages in CTA and CN. PMID: 23268488 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association ...
The International Medical Informatics Association (IMIA) is an independent organization that plays a role in promoting and furthering the application of information science in modern society, particularly in the fields of healthcare, bioscience and medicine. It was established in 1967 as a technical committee of the International Federation for Information Processing (IFIP). It became an independent organization in 1987 and was established under Swiss law in 1989. the promotion of informatics in health care and biomedical research the advancement of international cooperation the stimulation of research, development and education the dissemination and exchange of information Inherent in this mission is to bring together, from a global perspective, scientists, researchers, vendors, consultants and suppliers in an environment of cooperation and sharing. The international membership network of national member societies, IMIA regions, corporate and academic institutional members, and working and ...
AbstractThe use of social media in the urologic community is common and increasing. Although the potential benefits of platforms like Twitter have been described in the literature, the use of social media in the clinical context of Urology has not been explored.In this case report, we describe how we used Twitter to share ideas about the clinical management of a complex urologic patient. By posting a clinical scenario, a timely discussion was generated with global participation and expert suggestions. This knowledge was applied to the surgical management of a patient with positive clinical outcomes.The ability of Twitter t ...
Dr. Hadi Kharrazi is the assistant professor of Health Policy and Management at the Johns Hopkins Bloomberg School of Public Health with a joint appointment at the Johns Hopkins School of Medicine. He is the assistant director of the Johns Hopkins Center for Population Health IT (CPHIT) and serves on the Public Health Informatics Working Group Executive Committee of the American Medical Informatics Association (PHI-WG AMIA). As the assistant director of CPHIT, Dr. Kharrazi is pursuing priority Population Health Informatics (PHI) research interests that provide direct population-based applications to providers, patients, and payers. His research focuses on leveraging informatics to advance population health and improve cost. He is currently the PI of two AHRQ grants with special focus on population health: (1) an R21 grant to develop and evaluate a 30-day hospital readmission prediction model based on HIE data in Maryland; (2) a, ACTION-II contract to evaluate population health / coordination ...
Bio I am a faculty member in Biomedical Informatics Research at Stanford and board-certified internal medicine and clinical informatics. I split my time between clinical practice, hospital medical informatics and applications of artificial intelligence in healthcare. I work with the Clinical Excellence Research Center ? a research group dedicated to reducing the cost of high-quality care ? directing the Partnership in AI collaboration with the Stanford Artificial Intelligence Lab. Recognizing that the complexity of medicine has grown beyond the abilities of even the most expert clinician, we focus applications of computer vision to address some of the greatest challenges in healthcare: perfecting intended care for frail patients in settings ranging from the intensive care unit to the home. I have published work in the New England Journal of Medicine, Health Affairs, Annals of Internal Medicine, and the Journal of the American Medical Informatics Association. My interests include a design-based ...
MedInfo2017 Submission deadline: 1st December 2016.. The 16th World Congress on Health and Medical Informatics (MEDINFO-2017) will be held in Xiamen, China, 21st-25th August 2017. MEDINFO is the premier international health and biomedical informatics event; it has travelled across 6 continents and 13 countries worldwide since 1974. MEDINFO-2017 will be hosted by CMIA (Chinese Medical Informatics Association) on behalf of the International Medical Informatics Association (IMIA). It will be an historical event as 2017 marks IMIAs 50th anniversary.. Under the theme: Precision Healthcare through Informatics, the world leaders in this field will gather in China to share knowledge and analyze how Digital Health and Biomedical Informatics address some of the most challenging problems in health care, public health, consumer health, and biomedical research.. We invite researchers, clinicians, technologists and managers to contribute and share experiences on the use of information methods, systems and ...
Electronic health records (EHRs) hold the promise to improve primary health care for millions of patients. However, enhancing current EHR functionality is needed to better support primary care clinicians and patients, according to a recent article in the Journal of American Medical Informatics Association.. The adoption and use of electronic health records could greatly improve health care and lead to better patient outcomes, yet many clinicians are dissatisfied with current EHR systems, said Alex Krist, M.D., lead author of the article, member of the Cancer Prevention and Control research program at VCU Massey Cancer Center, and associate professor of family medicine and population health in the VCU School of Medicine. Enhancements to electronic record functionality are needed to better support care. Primary care needs EHRs to move beyond focusing on disease and instead focus on the whole person.. Objectives of EHRs remain focused on disease, ignoring the many factors that can play a role ...
Lurio J, Morrison FP, Pichardo M, Berg R, Buck MD, Wu W, Kitson K, Mostashari F, Calman N. Journal of the American Medical Informatics Association. 2010 Mar 1;
Introduction to Clinical Informatics fills a void in the Computer in Health Care series. With this volume, Patrice Degoulet and Marius Fieschi provide a comprehensive view of medical informatics and carry that concept forward into the realm of clinical informatics. The authors draw upon their experi- ences as medical school faculty members in France, where informatics has long been integrated into the curriculum and where the French version of this very book has been used, tested, and revised. In intent and content, this volume stands as the companion volume to Introduction to Nursing Informatics, one of the series best selling titles. For practitioners and students of medicine, pharmacy, and other health profes- sions, Introduction to Clinical Informatics offers an essential understanding how computing can support patient care, clarifying practical uses and critical issues. Today medical schools in the United States are making informatics a part of their curriculum, with required medical ...
Here are what the editors at HealthDay consider to be the most important developments in Pain Management for August 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.. Minimal Evidence for Electronic Communication Guidelines. THURSDAY, Aug. 31, 2017 (HealthDay News) - Minimal evidence is available for guidelines for electronic communication between patients and providers, according to research published online Aug. 28 in the Journal of the American Medical Informatics Association.. Abstract/Full Text (subscription or payment may be required). Proactive Approach Encouraged for Online Patient Reviews. WEDNESDAY, Aug. 30, 2017 (HealthDay News) - Most patients are using online reviews as a first step to finding a new doctor, with 65 percent forming an opinion from reading one to six reviews, according to a report published in Medical Economics.. Abstract/Full ...
An online disease management system for patients with uncontrolled type 2 diabetes resulted in significantly reduced A1C levels and improved diabetes control after 6 months but that improvement was not sustained after 12 months, according to a study published in the March issue of the Journal of the American Medical Informatics Association.
The Health division of Wolters Kluwer, a leading global provider of information and point of care solutions for the healthcare industry, announced today that The Journal of the American Medical Informatics Association (JAMIA) has published a study by researchers Sharad Manaktala, MD, PhD, et al. detailing a significant
MR Boland, P Parhi, R Miotto, R Carroll, U Iqbal, P-A Nguyen, M Schuemie, SC You, D Smith, S Mooney, P Ryan, Y-C Li, RW Park, J Denny, JT Dudley, G Hripcsak, P Gentine, NP Tatonetti.: Uncovering exposures responsible for birth season - disease effects: a global study. Journal of the American Medical Informatics Association (JAMIA) Sept 2017 ...
The electronic tools that are designed to prevent errors in prescriptions have their own issues, according to researchers from Brigham and Womens Hospital and Massachusetts General Hospital.. An analysis of almost 4,000 computer-generated prescriptions sent to a commercial pharmacy chain over a four-week period uncovered errors in more than 10 percent of the prescriptions. One third of those errors had the potential to cause a patient harm, according to the researchers, whose findings appear in the Journal of the American Medical Informatics Association.. SOURCE ...
Kannan, V., Basit, M. A., Bajaj, P., Carrington, A. R., Donahue, I. B., Flahaven, E. L., Medford, R., Melaku, T., Moran, B. A., Saldana, L. E., Willett, D. L., Youngblood, J. E. & Toomay, S. M., Nov 1 2019, In : Journal of the American Medical Informatics Association : JAMIA. 26, 11, p. 1344-1354 11 p.. Research output: Contribution to journal › Article ...
Hohl, C. M.; Karpov, A.; Reddekopp, L.; Stausberg, Jürgen; Doyle-Waters, M. (2013): ICD-10 codes used to identify adverse drug events in administrative data: a systematic review. In: Journal of the American Medical Informatics Association (JAMIA), Vol. 21, No. 3: pp. 547-557 ...
Masica, D. L. , Molin, M. D. , Wolfgang, C. L. , Tomita, T. , Ostovaneh, M. R. , Blackford, A. , Moran, R. A. , Law, J. K. , Barkley, T. , Goggins, M. , Canto, M. I. , Pittman, M. , Eshleman, J. R. , Ali, S. Z. , Fishman, E. K. , Kamel, I. R. , Raman, S. P. , Zaheer, A. , Ahuja, N. , Makary, M. A. & 16 others Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & Lennon, A. M. 2017 In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.. Research output: Research - peer-review › Article ...
Kass-Hout, Taha A; Xu, Zhiheng; McMurray, Paul; Park, Soyoun; Buckeridge, David L; Brownstein, John S; Finelli, Lyn et al. (Journal of the American Medical Informatics Association : JAMIA, 2012) Link to Published Version ...
We provide secure, cost-effective access to the UKs richest collection of digital content: giving you access to the latest data and content from leading international publishers and providers.. Find out more at jisc.ac.uk. ...
BMI is the core scientific discipline that supports applied research and practice in several biomedical disciplines, including health informatics, which is composed of clinical informatics (including subfields such as medical, nursing, and dental informatics) and public health informatics (sometimes referred to more broadly as population informatics to capture its inclusion of global health informatics). There are related notions, such as consumer health informatics, which involves elements of both clinical and public health informatics. BMI in turn draws on the practical experience of the applied subspecialties, and works in the context of clinical and public health systems and organizations to develop experiments, interventions, and approaches that will have scalable impact in solving health informatics problems. However, it is the depth of informatics methods, shared across the spectrum from the molecular to the population levels that defines the core discipline of BMI and provides its ...
The purpose of the proposed project, entitled The Ohio State University Clinical and Translational Research Informatics Training Program (CTRIP)...
The Informatics Training for Global Health program supports informatics research training in low- and middle-income country institutions in partnership with U.S. institutions and investigators. Training is integrated with ongoing research at the foreign institutions to develop informatics capacity and support research. Training must address the health and informatics needs of the collaborating countries. Prospective students from the countries listed should contact the Principal Investigator. ...
Methods of Information in Medicine is a peer-reviewed scientific journal covering research in medical informatics. It is an official journal of the International Medical Informatics Association, the European Federation for Medical Informatics, and the German Association for Medical Informatics, Biometry and Epidemiology. It is the oldest and longest running journal in its field. The journal is abstracted and indexed in: Current Contents/Clinical Medicine Embase/Excerpta Medica EmCare Index Medicus/MEDLINE/PubMed Science Citation Index Scopus According to the Journal Citation Reports, the journal had a 2014 impact factor of 2.2. In 2015 the journal did not receive an impact factor as it was delisted because of citation stacking . The 2016 impact factor subsequently fell to 1.8 The editors of Methods of Information in Medicine and the other journal involved, Applied Clinical Informatics published a rebuttal in an editorial in both journals. The president and publication officer of the European ...
Over the past 30 years, biomedical informatics has emerged as an independent, rigorous discipline. Due to the rapid growth of clinical information systems, networked healthcare platforms, high-throughput genomic technologies, and consumer and public health informatics, the demand for knowledgeable and experienced staff and faculty has far outpaced the number of available trainees. Students who earn the University of Chicago Master of Science in Biomedical Informatics degree will be prepared with the necessary knowledge and technical skills to tackle everyday management issues and to guide large informatics projects in clinical and research settings. Join us for an online information session to learn program details and admission requirements as well as chat with program director Suzanne Cox, PhD.. Register for the session here.. ...
Jun 12, 2017 , HISA news, International Health News. The International Medical Informatics Association (IMIA) has concluded a lengthy election process of living leaders in health informatics worldwide, who became the first class of the International Academy of Health Sciences Informatics (IAHSI). The Academy will serve ...
2001 (English)In: Yearbook of medical informatics: Digital libraries and medicine / [ed] Reinhold Haux; Casimir Kulikowski; International Medical Informatics Association, Stuttgart: Schattauer , 2001, 259-262 p.Chapter in book (Other academic) ...
Tim Althoff is a PhD candidate in Computer Science Department at Stanford University. His research advances computational methods to improve human well-being, combining techniques from Data Science, Social Network Analysis, and Natural Language Processing. Tim is advised by Jure Leskovec and is a member of the Stanford InfoLab and the Stanford Mobilize Center. Prior to his PhD, Tim obtained MS and BS degrees from Stanford University and University of Kaiserslautern, Germany. He has received several fellowships and awards including the SAP Stanford Graduate Fellowship, Fulbright scholarship, German Academic Exchange Service scholarship, the German National Merit Foundation scholarship, and a Best Paper Award by the International Medical Informatics Association. Tims research has been covered internationally by news outlets including BBC, CNN, The Economist, The Wall Street Journal, and The New York Times. ...
Clinical informatics is a field that has been booming since Congress 2009 mandate that health systems convert all paper records to electronic databases. The field essentially applies the various tasks, skills, and tools of information technology to the medical field. Medical records databases are a huge concern for the field, but informatics specialists also build graphic user interfaces, address hardware and software problems, train staff on the systems, and monitor network traffic and usage.. Informatics professionals can work in a wide variety of settings. Many can be found working in hospitals or other large health systems, but they might also work in state or federal public health agencies. They can also work as independent contractors who are tasked with designing and implementing databases. Informatics workers can spend hours coding mobile apps that are designed for use by doctors, nurses, and even patients. Others might work to link departments and healthcare providers so that each ...
CONTEXT There is a growing interest in and need for continuing education in medical informatics delivered by distance learning. OBJECTIVES Implement and evaluate a distance learning introductory course in medical informatics. METHODS A Web-based version of our on-campus Introduction to Medical Informatics course was implemented using streaming audio lectures, threaded discussion boards, and several other teaching modalities. Evaluation was performed using an adaptation of our on-campus course evaluation instrument. RESULTS The course was implemented with no major technological or pedagogical problems. Student satisfaction with teaching modalities and other course modalities was high. CONCLUSIONS The learning technologies used in this course were implemented successfully and a Graduate Certificate Program is planned to further meet educational needs in medical informatics.
The Department of Health Outcomes & Policys Ph.D. in Medical Sciences with a concentration in Biomedical Informatics was approved by the UF Graduate School on September 15. The multidisciplinary program features health outcomes, computer science, biostatistics and philosophy courses from across the UF campus to equip students with the advanced concepts they need for academic and research careers in the growing field of biomedical informatics. The goal is to begin recruiting students for Fall 2017 enrollment in the 90 credit, on-campus program.. This program is the capstone of more than two years of effort to bridge a critical gap in the educational offerings at the University of Florida, said Bill Hogan, M.D., M.S., professor of health outcomes and policy and director of the biomedical informatics program at the UF CTSI. Now, UF has a suite of biomedical informatics degrees that will help develop the translational science workforce of the state. The Ph.D., in particular, will amply prepare ...
3). @2-year M.P.H and 1-year M.P.H in the Department of Health Informatics in the Shool of Public Health We offer 2-year Master of Publics Health (M.P.H) course and the 1-year M.P.H program in the School of Publics Health. See the homepage of the Shool of Publics Health.. 4). @2-year M.M.S in the Department of Health Medical Informatics in the Medical Science Graduate Program. @Graduate School @of Medicine, the University of Tokyo, offers the master course in Medical Sciences. The course was established for students who graduate from faculties other than a 6-year program at Faculty of Medicine and eventually wish to advance to the Medical Sciences doctoral course of the University of Tokyo. It enables students to enroll in the department they plan to carry out their research for Doctor of Medical Science. (the entrance examination required for enrollment in Medical Sciences doctoral course) In this Master fs course, all students entering the course spend the first four months taking formal ...
Medical informatics studies the nature of medical information and the use of information technology to manage health-related records and content in medical practice, education, and research. With increases in the application and uses of information technology to the medical industry, there is an unprecedented need for professionals who can use their knowledge of both information technology and health care to improve the safety and quality of health care delivery, plus help control costs.. Medical informatics is an emerging profession in which the power of information technology is creatively applied to the information needs of health care. This includes the acquisition, storage, and retrieval of patient data, as well as access to electronically maintained medical knowledge for use in patient care, research, and education. This field requires computing expertise; understanding formal medical terminology, clinical processes, and guidelines; and the application of information and communication ...
What is Health Informatics? What discipline combines information technology, programming, analytical skills, communication abilities, and a deep desire to improve healthcare quality and safety? Health Informatics. Health Informatics encompasses the management (acquiring, storing, retrieving, and utilizing) of healthcare information to foster… Continue Reading →. ...
UCLAs history of research and training in medical informatics goes back several decades, starting in the 1980s with the genesis of what are now foundational ideas in clinical and imaging information systems. Since that time, we have led in the development of technologies and methodological developments aimed at transforming biomedical research and healthcare processes through the lens of informatics. Over this period, medical informatics has evolved into a rich discipline representing a full spectrum of activities, from conceptual frameworks through to more applied research and evaluative studies. UCLA is a place for envisioning the future of healthcare: what should it look like in a decade, and how can technology make it better? ...
The University of Kansas Center for Interprofessional Health Informatics (KU-CIHI) is an interprofessional center of excellence designed to advance health informatics through knowledge, integration, research and empowerment of faculty and students in the expanding field of applied health informatics.
Apply to 6 Health informatics Jobs on Monster.com.hk, Hong Kongs Best Online Job Portal. Find Latest Health informatics Job vacancies for Freshers & Experienced across Top Companies.
The SYMBIOmatics Specific Support Action (SSA) is a European funded project. The main goal is to identify synergies between the bioinformatics (BI) and medical informatics (MI) research domains. In addition to experts that are approached through a survey, input will also be gathered from the analysis of scientific literature. In this paper, we focus on the analysis of scientific literature.. Bioinformatics (BI) and medical informatics (MI) are two research fields that have become mature in the past 20 years. They serve the needs of different but related research communities: BI provides solutions to scientists doing biological research whereas MI fulfils the demands from clinical personnel, for practitioners and scientists in medical research [1, 2]. Although biological research may be part of a medical research project, it is often unclear how BI and MI research are coupled together [3]. Both research domains profit from progress in new IT developments and computer science as well as related ...
Derive meaningful clinical insights from healthcare data to improve outcomes. Healthcare data is increasingly difficult to analyze. Its complex underlying taxonomy of codes and clinical criteria make it difficult to understand the data, how to use it, and maintain current definitions. In addition, many organizations are stretched for clinical resources, making it difficult to move critical initiatives ahead at the desired pace and accuracy.. As healthcare organizations move toward value-based care, they need to manage key clinical KPIs such as gaps in care, cost and utilization by service areas, disease flags, etc., more efficiently and accurately. At EXL Health, we make it easier for you to drive meaningful KPIs.. With our clinical informatics expertise and robust clinical library based on industry guidelines, we accelerate your speed to value for:. ...
Holistics Medicine and Clinical Informatics scheduled on November 18-19, 2022 in November 2022 in Singapore is for the researchers, scientists, scholars, engineers, academic, scientific and university practitioners to present research activities that might want to attend events, meetings, seminars, congresses, workshops, summit, and symposiums.
Phys.org Science News Wire : Clinical informatics subspecialty launched at UCSF -- a press release is provided to you ìas isî with little or no review from Phys.org staff.
Are you interested in a career in clinical informatics? Find out how to get involved while this emerging niche is still in the grandfathering phase.
Following a competitive proposal process, the Center for Research Informatics has been selected to lead the development of an enterprise clinical trials management system to be used for clinical research efforts across the University of Chicago Biological Sciences Division. The project was officially launched last week at a meeting led by Dean Kenneth Polonsky and attended by the Advisory Group for the project, a broad group of information technology leaders from across the University.. Over the coming months, the CRI will lead the process of designing and building a new system and integrating it with the BSD information systems already in place. We are now building our team for this project - see the job opening for a Senior Program Manager here. As the development phase is completed, this team will lead a new branch of the CRI dedicated to maintaining the system and supporting BSD clinical informatics as a whole.. The CRI is excited to be taking on this ambitious, high-impact project and we ...
Samuel Volchenboum, M.D., Ph.D.. Here is a link to the programs core curriculum. As the programs website notes, Our curriculum has undergone scrutiny by faculty and industry partners to ensure its relevance and applicability to the current workforce needs in biomedical fields. The goal of the program is for students to learn and master the following: informatics methodology, applying tools and techniques to both research and applied problems in biomedical settings; effective communication with diverse professional audiences regarding informatics issues and solutions; management of biomedical informatics projects; understanding of the ethical, privacy, and data security issues in the field.. Shortly after the inception of the program, Dr. Volchenboum spoke with HCI Editor-in-Chief Mark Hagland regarding the program specifically and the development of degree programs in medical informatics more broadly. Below are excerpts from that interview.. Congratulations on the launch of this new program. ...
Next-generation sequencing (NGS) is revolutionizing the discipline of laboratory medicine, with a deep and direct impact on patient care. Although it empowers clinical laboratories with unprecedented genomic sequencing capability, NGS has brought along obvious and obtrusive informatics challenges. Bioinformatics and clinical informatics are separate disciplines with typically a small degree of overlap, but they have been brought together by the enthusiastic adoption of NGS in clinical laboratories. The result has been a collaborative environment for the development of novel informatics solutions. Sustaining NGS-based testing in a regulated clinical environment requires institutional support to build and maintain a practical, robust, scalable, secure, and cost-effective informatics infrastructure.. ...
ANUNŢ. SC THE SCIENCE CITY FOR RESEARCH AND MEDICAL INFORMATICS SA Târgu Mureş, cu sediul în Târgu Mureş, str. Bartok Bela nr.2/A, prin Comisia de evaluare/selecţie a candidaţilor pentru Consiliul de Administraţie al societăţii,. Anunţă organizarea evaluării/selecţiei prealabile a candidaţilor, în conformitate cu prevederile OUG nr. 109/2011 privind guvernanţa corporativă a întreprinderilor publice, pentru funcţia de membru în Consiliul de Administraţie, precum și pentru funcţia de membru în Comisia de Cenzori a SC THE SCIENCE CITY FOR RESEARCH AND MEDICAL INFORMATICS SA Târgu Mureş.. Etapele de desfăşurare a selecţiei:. 1. Selecţia dosarelor de înscriere;. 2. Interviul candidaţilor selectaţi.. Candidaturile şi documentele solicitate se vor depune până la data de 31.07.2020 ora 14.00 în Târgu Mureş, Piaţa Victoriei nr. 3, cam. 68.. Informaţii detaliate, documentele necesare depunerii candidaturii, bibliografia şi criteriile de selecţie vor fi ...
Context.-Next-generation sequencing (NGS) is revolutionizing the discipline of laboratory medicine, with a deep and direct impact on patient care. Although it empowers clinical laboratories with unprecedented genomic sequencing capability, NGS has brought along obvious and obtrusive informatics challenges. Bioinformatics and clinical informatics are separate disciplines with typically a small degree of overlap, but they have been brought together by the enthusiastic adoption of NGS in clinical laboratories. The result has been a collaborative environment for the development of novel informatics solutions. Sustaining NGS-based testing in a regulated clinical environment requires institutional support to build and maintain a practical, robust, scalable, secure, and cost-effective informatics infrastructure ...
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To be presented at AMIA 2018 Symposium, Session S68: 10:30 12:00 PST YQ Panel -Implementation Science for Global Health Informatics Projects Panel Chair: Yuri Quintana, Ph.D., Director Global Informatics, Division of Clinical Informatics, Beth Israel Deaconess Medical Center, Assistant Professor of Medicine, Harvard Medical School Panelists:
Dr. Sengstack is the Chief Nursing Informatics Officer for the Bon Secours Health System and is the former Deputy CIO and Chief of Clinical Informatics at the National Institutes of Health, Clinical Center in Bethesda, MD. She has her DNP from Vanderbilt University and a Masters in Nursing Informatics from the University of Maryland. She is currently serving as the President of the American Nursing Informatics Association (until April 2015).
The number of published sequenced genomes has been growing in recent years, and at the present time, about 800 microbial genomes are fully sequenced. The next step after sequencing is to predict genes and their functions from the sequence. The explosion of sequence information has widened the gap between the number of predicted proteins and the number of experimentally characterized ones. Escherichia coli K12 is best characterized, but still has 15% of genes with unknown function. Other genomes have between 15% and 70% uncharacterized genes. The best established method for function prediction is based on sequence homology to proteins of known function. Unfortunately, strictly homology-based predictions are of limited use due to the large number of homologous protein families with no known function for any member. Another way to assess the function of a sequence is through identification of its interactions with other proteins. Co-conservation (phylogenetic profiles) is an alternative source of ...