TY - JOUR. T1 - Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP). AU - Sato, Hiroshi. AU - Takino, Takahisa. AU - Kinoshita, Takeshi. AU - Imai, Kazushi. AU - Okada, Yasunori. AU - Stetler Stevenson, William G.. AU - Seiki, Motoharu. PY - 1996/5/6. Y1 - 1996/5/6. N2 - Gelatinase A is secreted as a proenzyme (progelatinase A) which is activated and bound on the surface of tumor and normal cells. We have reported that the expression of a membrane-type-1-matrix metalloproteinase (MT1-MMP) induces activation of progelatinase A. Here we demonstrate that the expression of MT1-MMP in COS-1 cells induces cell-surface binding of progelatinase A which is consequently processed to an intermediate form. Processing from the intermediate to the fully active form is dependent on the gelatinase A concentration. These results suggest that the cell-surface binding concentrates the gelatinase A intermediate form locally to allow ...

in Journal of Biological Chemistry (2009), 284(19), 12727-34. Membrane type-1 matrix metalloproteinase (MT1-MMP) is an activator of soluble MMP-2. The activity of both MMPs is regulated by their physiological inhibitor TIMP-2. An MT1-MMP/MMP-2/TIMP-2 axis plays a ... [more ▼]. Membrane type-1 matrix metalloproteinase (MT1-MMP) is an activator of soluble MMP-2. The activity of both MMPs is regulated by their physiological inhibitor TIMP-2. An MT1-MMP/MMP-2/TIMP-2 axis plays a key role in the invasive behavior of many cell types. Despite its importance, epigenetic control of this pro-invasive axis is insufficiently studied, and, as a result, its modification in a rational and clinically beneficial manner is exceedingly difficult. Therefore, we performed an epigenetic analysis of the MT1-MMP, MMP-2, and TIMP-2 gene promoters in highly migratory glioblastoma cells and in low migratory breast carcinoma MCF-7 cells. We determined, for the first time, that the epigenetic control leading to the ...

Pericellular proteolysis of the extracellular matrix by membrane type 1-matrix metalloproteinase (MT1-MMP) confers tumor cells with the ability to proliferate within three-dimensional (3D) matrices and sustains tumor growth in mice. In this study, we show that in addition to its matrix-degrading activity, phosphorylation of MT1-MMP on its unique tyrosine residue located within its cytoplasmic sequence (Tyr573) may also participate to these processes. Fibrosarcoma cells expressing a proteolytically active but non-phosphorylable mutant of MT1-MMP showed a markedly reduced proliferation rate when embedded within 3D type I collagen matrices, this antiproliferative effect being correlated with arrest in the G0/G1 phase of the cell cycle. Impaired tyrosine phosphorylation of MT1-MMP also inhibits anchorage-independent growth of HT-1080 cells in soft agar as well as their invasion of collagen barriers, two prominent attributes of tumor cells, suggesting a broad inhibitory effect of the MT1-MMP mutant ...

EXTERNAL SPEAKER. Dr Sara Rossana Zanivan, Senior Lecturer, Beatson Institute for Cancer Research, University of Glasgow. Pro-invasive tumour-stroma interactions:thekey role of cancer associated fibroblasts. Hosted in room C1071 C Floor South Block Queens Medical Centre and dual broadcast to The Staff Room Academic Oncology 1st Floor above South Entrance City Hospital. This forms part of the Division of Cancer & Stem Cells seminar series ...

이 연구는 뇌허혈에 의한 MMP 활성과 신경세포손상에 대하여 운동과 스트레스가 어떠한 영향을 주는지 알아보고자 하였다. 사용된 허혈모델은 국소 및 전뇌허혈 모델이었다. 운동군은 허혈 수술 전 자발적 activity wheel에서 운동 시킨 마우스들로 구성되었고, 스트레스군에서는 허혈 수술 전 마우스에 하루 3시간, 7일 동안 부동스트레스를 가하였다. 국소뇌허혈에 의한 뇌경색 부피는 운동에 의해 감소하였고 스트레스에 의해 증가하였다. 전뇌허혈 모델 역시 운동에 의해 해마신경세포 손상이 감소하였고, 스트레스에 의해 증가하였다. 한편, 스트레스는 국소뇌허혈 및 전뇌허혈 두 모델에서 운동에 의한 효과를 감소시켰다. 이 연구의 MMP에 대한 관찰에 있어 MMP-9 활성은 국소뇌허혈 및 전뇌허혈 두 가지에서 증가하였고, 운동에 의해 허혈에 의한 MMP-9 활성 증가가 ...

During a physical activity, such as sports, the increased muscle mass puts heavy pressure on the joints. The strength of BioSil OYG provides the collagen-rich tissues in and around the joint with the extra support they need. ...

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MMP9小鼠单克隆抗体[56-2A4](ab58803)可与大鼠, 兔, 豚鼠, 人样本反应并经WB, IHC, ICC/IF实验严格验证，被14篇文献引用并得到5个独立的用户反馈。

MS10-9 MMP13遺伝子の気管支喘息との相関と気道上皮における役割(気道上皮細胞/線維芽細胞/血管内皮細胞とアレルギー病態1,第59回日本アレルギー学会秋季学術大会) （2009 ...

Among the five membrane-type matrix metalloproteinases (MT-MMPs), MT1-, MT2-, MT3-, and MT5-MMPs have about a 20-amino acid cytoplasmic tail following the transmembrane domain. In contrast, a putative transmembrane domain of MT4-MMP locates at the very C-terminal end, and the expected cytoplasmic tail is very short or nonexistent. Such sequences often act as a glycosylphosphatidylinositol (GPI) anchoring signal rather than as a transmembrane domain. We thus examined the possibility that MT4-MMP is a GPI-anchored proteinase. Our results showed that [(3)H]ethanolamine, which can be incorporated into the GPI unit, specifically labeled the MT4-MMP C-terminal end in a sequence-dependent manner. In addition, phosphatidylinositol-specific phospholipase C treatment released the MT4-MMP from the surface of transfected cells. These results indicate that MT4-MMP is the first GPI-anchored proteinase in the MMP family. During cultivation of the transfected cells, MT4-MMP appeared to be shed from the cell surface by

Background: Akt is a critical molecule in several signal transduction pathways involved in vascular responses. Membrane type 1-matrix metalloproteinase (MT1-MMP), a membrane-anchored MMP, functions as a signaling molecule in addition to a proteolytic enzyme.. Hypothesis: Akt cooperates with MT1-MMP in tumor necrosis factor (TNF)-alpha-induced signaling pathways of vascular responses including endothelial dysfunction and haemostasis.. Methods and Results: TNF-alpha (10 ng/mL) induced a transient increase in Akt phosphorylation within 15 minutes, followed by the profound decrease of Akt phosphorylation and the increase in MT1-MMP activity within 60 minutes, in cultured human aortic endothelial cells (ECs). To demonstrate the role of MT1-MMP for Akt signaling pathway in TNF-alpha-stimulated ECs, we used siRNA to knockdown MT1-MMP protein in ECs. Silencing of MT1-MMP reversed TNF-alpha-triggered transient upregulation of Akt phosohorylation within 15 minutes and the downregulation within 60 minutes, ...

Supplementary MaterialsReviewer comments JCB_201812098_review_background. In xenograft-based research, SNX27-depleted cell lines demonstrated prolonged success of SCID mice, recommending a possible implication for overexpression from the sorting in tumor samples nexin. Graphical Abstract Open up in another window Launch MT1-MMPCmediated ECM degradation Metastasis to a second site is one of the significant reasons of tumor relapse and cancer-associated fatalities all over the world. Invasive cancers cells type actin-rich plasma membrane protrusions known as invadopodia that facilitate breaching from the root cellar membrane. Invadopodia become molecular scissors, where several proteases are frequently sent to degrade ECM (Linder et al., 2011). Membrane type 1 matrix metalloproteinase (MT1-MMP), a known person CB1954 in the MMP family members, is really a well-studied invadosome-associated protease (Jab?oska-Trypu? et al., 2016; Itoh, 2015; Holmbeck et al., 2003; Jiang et al., 2006; Sodek et al., ...

Fingerprint Dive into the research topics of In vitro regulation of pericellular proteolysis in prostatic tumor cells treated with bombesin. Together they form a unique fingerprint. ...

Background: Pressure-overload causes left ventricular (LV) remodeling with one of the structural milestones of this process being extracellular matrix remodeling and fibrosis. While the regulation of matrix metalloproteinases (MMPs) likely plays a role in this process, the induction and mechanistic role of specific MMPs is poorly understood. Recent in-vivo studies have suggested that the transmembrane MMP, MT1-MMP can actually induce a profibrotic process and thereby effect matrix remodeling and fibrosis in PO. This study tested the hypothesis that in-vivo induction of MT1-promoter activity and expression occurs with PO.. Methods: MT1-MMP promoter activity (MT1-PROM act) was measured by generating a transgenic mouse (FVB; full length human MT1-MMP promoter ligated to the firefly luciferase gene). MT1-MMP PROM reporter mice underwent PO (4 weeks transverse aortic constriction n = 13) and were compared to non-banded controls (n = 10). In-vivo MT1-PROM act was quantified by luciferase mRNA ...

Rathke-Hartlieb, S, Budde, P, Ewert, S, Schlomann, U, Staege, MS, Jockusch, Harald, Bartsch, JW, and Frey, Jürgen. 2000. Elevated expression of membrane type I metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS LETTERS 481 (3): 227-234 ...

Nandhu, MS, et al. (2017) Tumor-derived fibulin-3 activates pro-invasive NF-κB signaling in glioblastoma cells and their microenvironment. Oncogene. 2017 Apr 17;. PM ID: ...

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兔多克隆抗体to MMP3一抗数据表(ab53015).Abcam抗体、ELISA、激动剂拮抗剂、表观遗传试剂、蛋白多肽，使用效果保证，中国70%以上现货。

Mô tả: Membrane-type 5-matrix metalloproteinase (MT5-MMP) is a proteinase mainly expressed in the nervous system with emerging roles in brain pathophysiology. The implication of MT5-MMP in Alzheimers disease (AD), notably its interplay with the amyloidogenic process, remains elusive. Accordingly, we crossed the genetically engineered 5xFAD mouse model of AD with MT5-MMP-deficient mice and examined the impact of MT5-MMP deficiency in bigenic 5xFAD/MT5-MMP(-/-) mice. At early stages (4 months) of the pathology, the levels of amyloid beta peptide (Aβ) and its amyloid precursor protein (APP) C-terminal fragment C99 were largely reduced in the cortex and hippocampus of 5xFAD/MT5-MMP(-/-), compared to 5xFAD mice. Reduced amyloidosis in bigenic mice was concomitant with decreased glial reactivity and interleukin-1β (IL-1β) levels, and the preservation of long-term potentiation (LTP) and spatial learning, without changes in the activity of α-, β- and γ-secretases. The positive impact of... ...

The membrane-type matrix metalloproteinases (MT-MMPs) are a subclass of the matrix metalloproteinase (MMP) family which uniquely possess a C-terminal transmembrane domain and are initiators of an activation cascade for progelatinase A (MMP-2). Recent studies have shown that they can also efficiently directly degrade a number of matrix macromolecules. We now show that cells expressing MT1-MMP on their cell surfaces cause subjacent proteolysis of a gelatin film and that this proteolysis is inhibited by TIMP-2 but not by TIMP-1. These data indicate that expression of MT1-MMP on the cell surface may lead to both progelatinase A activation and extracellular matrix degradation.

Membrane type 1 matrix metalloproteinase (MT1-MMP) is a potent modulator of the pericellular environment and promotes tumor cell invasion and proliferation in many types of tumor. The activation of proMMP-2 and processing of collagen I by MT1-MMP have been thought to be important for its tumor-promoting function. These activities can be inhibited by mutant forms of MT1-MMP lacking the catalytic domain. However, the effect of such dominant-negative mutants has never been evaluated in vivo. Various mutants lacking the catalytic domain (dCAT) were prepared and confirmed to inhibit MT1-MMP activity in human fibrosarcoma HT1080 cells, and tumor cells expressing these mutants were implanted s.c. into nude mice to monitor tumor formation. Only the membrane-anchored form of a dCAT construct through the transmembrane domain [dCAT(1)] showed potent antitumor activity not only in HT1080 cells but also in gastric carcinoma MKN28 and MKN45 cells expressing MT1-MMP. A soluble form of dCAT lacking the transmembrane

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Membrane-type 1 matrix metalloproteinase (MT1- MMP) localizes at the front of migrating cells and degrades the extracellular matrix barrier during cancer invasion. However, it is poorly understood how the polarized distribution of MT1-MMP at the migration front is regulated. Here, we demonstrate that MT1-MMP forms a complex with CD44H via the hemopexin-like (PEX) domain. A mutant MT1-MMP lacking the PEX domain failed to bind CD44H and did not localize at the lamellipodia. The cytoplasmic tail of CD44H, which comprises interfaces that associate with the actin cytoskeleton, was important for its localization at lamellipodia. Overexpression of a CD44H mutant lacking the cytoplasmic tail also prevented MT1-MMP from localizing at the lamellipodia. Modulation of F-actin with cytochalasin D revealed that both CD44H and MT1-MMP co-localize closely with the actin cytoskeleton, dependent on the cytoplasmic tail of CD44H. Thus, CD44H appears to act as a linker that connects MT1-MMP to the actin cytoskeleton and to

We present a molecular dissection of the functional domains of cortactin relevant for invadopodia formation and function. In addition, through the expression of cortactin forms mutated in the residues previously found to be phosphorylated in vitro, we suggest the involvement of different kinases in the control of the ECM degradation machinery through the regulation of cortactin phosphorylation.. The overexpression of mutant or deleted forms of cortactin that are unable to bind the Arp2/3 complex, induces a substantial decrease in the ability of the cells to form invadopodia and hence degrade the ECM. In addition, the SH3 domain of cortactin, known to bind a number of relevant proteins such as N-WASP and dynamin 2, is also essential for invadopodia formation and ECM degradation. This is at variance with a recent report suggesting that the cortactin N-terminus is not required for invadopodia formation (Webb et al., 2007). A possible explanation is that the study was based on constitutively active ...

肺癌是男性和女性的癌症死亡原因中最常見的一種，其可分為小細胞肺癌和非小細胞肺癌。肺癌的形成和侵襲是一個多步驟的過程，其中涉及癌細胞與鄰近周圍基質間的多種蛋白交互作用，包括基質金屬蛋白酶（matrix metalloproteinase, MMP）和組織金屬蛋白酶抑製劑（tissue inhibitor of metalloproteinase, TIMPs）。基質金屬蛋白酶是一種鋅依賴性內肽酶家族，具有切割細胞外基質的能力。MMP家族中的明膠基質金屬蛋白酶，特別是MMP-2和MMP-9，會參與一些病理過程，例如腫瘤細胞轉移和血管新生。許多的侵入性惡性腫瘤，包括肺癌，皆表現大量的MMP相關酵素，例如 MMP-2、MMP-7、MMP-9、TIMP-1等。Tomatidine是由番茄萃取得到的天然固醇類生物鹼。最近的研究發現tomatidine可以降低發炎作用。Tomatidine對癌細胞轉移方面的研究尚不清楚。本實驗室先前的研究發現， ...

Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinas …

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AdhIL13 injected in naïve knee joints results in 1000 pg/ml hIL-13 after 1 day, and increased to 3000 pg/ml detected at days 2, 3 and 7. Surprisingly, IL-13 did not diminish joint inflammation, because the influx of inflammatory cells was similar in the Addel70 and AdhIL13 group. MMP-mediated VDIPEN expression was not found 1 day after ICA onset because of the early time point. At day 3, IL-13 overexpression resulted in a twofold reduction in VDIPEN expression and a threefold reduction at day 7, compared with the control group. This decrease might be the result of a declined production of MMPs. However, the mRNA level of MMP-3 was comparable between the two groups, whereas MMP-12 and MMP-13 mRNA levels were three times higher in the IL-13 group. ...

Sigma-Aldrich offers abstracts and full-text articles by [Taís M Campos, Sara T Passos, Fernanda O Novais, Daniel P Beiting, Rúbia S Costa, Adriano Queiroz, David Mosser, Phillip Scott, Edgar M Carvalho, Lucas P Carvalho].

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TY - JOUR. T1 - Dendritic fibroblasts in three-dimensional collagen matrices. AU - Grinnell, Frederick. AU - Ho, Chin Han. AU - Tamariz, Elisa. AU - Lee, David J.. AU - Skuta, Gabriella. PY - 2003/2/1. Y1 - 2003/2/1. N2 - Cell motility determines form and function of multicellular organisms. Most studies on fibroblast motility have been carried out using cells on the surfaces of culture dishes. In situ, however, the environment for fibroblasts is the three-dimensional extracellular matrix. In the current research, we studied the morphology and motility of human fibroblasts embedded in floating collagen matrices at a cell density below that required for global matrix remodeling (i.e., contraction). Under these conditions, cells were observed to project and retract a dendritic network of extensions. These extensions contained microtubule cores with actin concentrated at the tips resembling growth cones. Platelet-derived growth factor promoted formation of the network; lysophosphatidic acid ...

3531 Lysophosphatidic acid (LPA) functions as a powerful mitogen and also as a stimulator of membrane vesicle shedding in ovarian cancer cells in vitro. These shed vesicles contain cell surface associated antigens such as β1-integrin, Membrane Type-1 Metalloproteinase (MT1-MMP) and Epidermal Growth Factor Receptor (EGFR). LPA engagement of the LPA receptor promotes transactivation of the EGFR. In this study we evaluate the functional roles of ovarian cancer derived membrane vesicles and examine their effect in the immediate tumor microenvironment. Epithelial ovarian carcinoma DOV13 cells were stimulated with 80 μM LPA to induce vesicle shedding. Membrane vesicles were isolated through differential centrifugation of the LPA-stimulated conditioned media. Vesicle composition was analyzed by western blot analysis, fluorescent immunostaining and gel zymography. The invasive potential of DOV13 cells, normal ovarian epithelial cells (IOSE), normal uterine smooth muscle (utSMC) and uterine ...

We previously reported that deficiency of membrane-type five matrix metalloproteinase (MT5-MMP) prevents amyloid pathology in the cortex and hippocampus of 5xFAD mice, and ameliorates the functional outcome. We have now investigated whether the integrity of another important area affected in Alzheimers disease (AD), the frontal cortex, was also preserved upon MT5-MMP deficiency in 4-month old mice at prodromal stages of the pathology. We used the olfactory H-maze (OHM) to show that learning impairment associated with dysfunctions of the frontal cortex in 5xFAD was prevented in bigenic 5xFAD/MT5-MMP(-/-) mice. The latter exhibited concomitant drastic reductions of amyloid beta peptide (Aβ) assemblies (soluble, oligomeric and fibrillary) and its immediate precursor, C99. Simultaneously, astrocyte reactivity and tumor necrosis factor alpha (TNF-α) levels were also lowered. Moreover, MT5-MMP deficiency induced a decrease in N-terminal soluble fragments of amyloid precursor protein (APP), ...

Proteolytic degradation of the extracellular matrix (ECM) is one intrinsic property of metastatic tumor cells to breach tissue barriers and to disseminate into different tissues. This process is initiated by the formation of invadopodia, which are actin-driven, finger-like membrane protrusions. Yet, …

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Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling.

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...

Komisi II DPRD Kaltim selaku mitra kerja PT MMP mengingatkan agar dirut yang baru untuk memperhatikan soal keuangan tersebut. Ini merupakan PR dirut yang baru untuk diselesaikan sesuai dengan mekanisme peraturan perundang- undangan, karena sebelum terpilih kan pasti sudah tahu persoalan perusda yang akan dipimpin, ujar Sutomo Jabir anggota komisi II DPRD Kaltim. Ditanya soal Rapat Dengar Pendapat (RDP) dengan dirut baru perusda PT. MMP, politisi PKB ini menegaskan belum pernah dilakukan.. Kekurangan pendapatan Participating Interest (PI) 10 persen Blok Mahakam di BUMD PT MMP senilai Rp248 miliar untuk disetorkan ke kas daerah ternyata telah dibahas dalam Rapat Umum Pemegang Saham Luar Biasa (RUPSLB). Kabarnya dalam RUPSLB tersebut diputuskan, PT MMP akan mengembalikan atau menyetorkan kekurangan pendapatan PI dari bagi hasil laba (dividen) Blok Mahakam ke kas daerah. Untuk MMP sudah RUPS tinggal disetor, ungkap Wakil Gubernur Kaltim, Hadi Mulyadi kepada Kalpostonline. Namun demikian, Hadi ...

Long-range transportation of contaminants from the Asian Continent to The Northern Japan Alps, recorded in snow cover on Mt. Nishi-Hodaka-Dake （2007 ...

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One of the hallmarks of human pancreatic ductal adenocarcinoma (PDAC) is its pronounced type I collagen-rich fibrotic reaction. Although recent reports have shown that the fibrotic reaction can limit the efficacy of gemcitabine chemotherapy, the underlying mechanisms remain poorly understood. In this article, we show that the type I collagen allows PDAC cells to override checkpoint arrest induced by gemcitabine. Relative to cells grown on tissue culture plastic, PDAC cells grown in 3-dimensional collagen microenvironment have minimal Chk1 phosphorylation and continue to proliferate in the presence of gemcitabine. Collagen increases membrane type 1 matrix metalloproteinase (MT1-MMP)-dependent ERK1/2 phosphorylation to limit the effect of gemcitabine. Collagen also increases MT1-MMP-dependent high mobility group A2 (HMGA2) expression, a nonhistone DNA-binding nuclear protein involved in chromatin remodeling and gene transcription, to attenuate the effect of gemcitabine. Overexpression of MT1-MMP ...

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Expression of matrix metalloproteinase 13 (MMP-13) in human rheumatoid arthritis (RA) (A) synovial tissue (magnification ×200) and (B) the isotype control (mag

PubMed journal article: Matrix metalloproteinase profile in patients with Creuztfeldt-Jakob disease. Download Prime PubMed App to iPhone, iPad, or Android

SPOKANE, WA (February 18, 2019) - A woman suffered broken bones after an alleged DUI car crash on Mt. Spokane Drive on February 14.

pep:known chromosome:VEGA66:11:83441876:83463071:-1 gene:OTTMUSG00000000928 transcript:OTTMUST00000001808 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Mmp28 description:matrix metalloproteinase 28 (epilysin ...

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