In recent years, it has become well established that risk patterns for both obesity and type 2 diabetes originate as a consequence of alterations in growth and metabolism during critical windows of prenatal and early postnatal development (1-5). Human studies of maternal undernutrition and low birth weight have shown that adult offspring develop an increased risk for obesity (1), type 2 diabetes (2,3), and cardiovascular disease (4,5). In humans, maternal obesity is also a risk factor for the development of obesity in offspring during childhood (6-8). In animal models, maternal high-fat feeding results in profound changes in offspring health, including increased rates of obesity and percent body fat (9-11), impaired glucose tolerance (12), increased adipocyte lipogenesis and proliferation (13), increased cardiovascular disease (14), decreased β-cell function (12), and increased food intake (15). Thus, both human and animal studies have shown severe metabolic effects of maternal over- and ...
NCDs are observed mostly in adults, however there is strong evidence that suggests NCDs origin early in life, thus the first 1000 days of life (conception to age 2yrs). Studies show that maternal BMI before conception and during pregnancy predict future risk of obesity and associated metabolic conditions in both mother and offspring. Weight gain during the first two years of life is also critical in defining the infants predisposition to obesity during adulthood. Objective: to assess the effectiveness of delivering a primary health care intervention to enhance compliance with updated nutrition and health care (diet, physical activity and breastfeeding) standards from early pregnancy through the first year of life. Methods: cluster randomized controlled trial (CRCT), designed as a public health intervention program effectiveness study (i.e. intervention will be available through the established national health system under standard operating conditions). A cluster unit will be a primary health ...
Inspired by breast milk, Gerber BabyNes, is an advanced nutrition system bringing six stages of single serve formulas together with a Wi-Fi-connected Machine.
We investigated maternal obesity in inbred SM/J mice by assigning females to a high-fat diet or a low-fat diet at weaning, mating them to low-fat-fed males, cross-fostering the offspring to low-fat-fed SM/J nurses at birth, and weaning the offspring onto a high-fat or low-fat diet. A maternal high-fat diet exacerbated obesity in the high-fat-fed daughters, causing them to weigh more, have more fat, and have higher serum levels of leptin as adults, accompanied by dozens of gene expression changes and thousands of DNA methylation changes in their livers and hearts. Maternal diet particularly affected genes involved in RNA processing, immune response, and mitochondria. Between one-quarter and one-third of differentially expressed genes contained a differentially methylated region associated with maternal diet. An offspring high-fat diet reduced overall variation in DNA methylation, increased body weight and organ weights, increased long bone lengths and weights, decreased insulin sensitivity, and changed
Sjm Welham, AA Jackson, SC Langley-Evans; Effect of Maternal Protein Restriction during Pregnancy on Renal Function. Clin Sci (Lond) 1 February 1997; 92 (s36): 14P. doi: https://doi.org/10.1042/cs092014P. Download citation file:. ...
DISCUSSION. In the present study, maternal HFD during the pregnancy (Experiment 1) or lactation (Experiment 2) induced changes in somatic and neurological development, promoting: 1. Reduced body weight and length early in life; 2. Overweight later in life; 3. Altered head growth; 4. Delayed reflex ontogeny; and 5. Delayed acquisition of mature developmental patterns of physical features. These changes are similar to those observed in the offspring of undernourished mothers 14 and opposite to those observed in dams with overnutrition 15 .. Several clinical and experimental studies have shown that prenatal (intrauterine) and early postnatal maternal nutrition have a significant role on food intake, body weight and energy homeostasis of the offspring 16 , 17 . Pups of dams fed HFD during pregnancy and lactation showed low birth weight and reduced body weight during lactation, compared with controls 16 , 18 . According to Niculesco and Lupu [5], high fat diet-induced maternal obesity has impaired ...
Maternal obesity, metabolic state, and diet during gestation have profound effects on offspring development. The prevalence of neurodevelopmental and mental health disorders has risen rapidly in the last several decades in parallel with the rise in obesity rates. Evidence from epidemiological studies indicates that maternal obesity and metabolic complications increase the risk of offspring developing behavioral disorders such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and schizophrenia. Animal models show that a maternal diet high in fat similarly disrupts behavioral programming of offspring, with animals showing social impairments, increased anxiety and depressive behaviors, reduced cognitive development, and hyperactivity. Maternal obesity, metabolic conditions, and high fat diet consumption increase maternal leptin, insulin, glucose, triglycerides, and inflammatory cytokines. This leads to increased risk of placental dysfunction, and altered fetal
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Background: Research directed to optimizing maternal nutrition commencing prior to conception remains very limited, despite suggestive evidence of its importance in addition to ensuring an optimal nutrition environment in the periconceptional period and throughout the first trimester of pregnancy. Methods/Study design: This is an individually randomized controlled trial of the impact on birth length (primary outcome) of the time at which a maternal nutrition intervention is commenced: Arm 1: |= 3 mo preconception vs. Arm 2: 12-14 wk gestation vs. Arm 3: none.
Evidence from epidemiological studies and animal models shows that suboptimal early nutrition affects susceptibility to obesity in later life. We and others have shown that rodents exposed to maternal protein restriction in utero and accelerated postnatal growth (recuperated offspring) are more susceptible to development of diet-induced obesity (Ozanne et al., 2004; Bieswal et al., 2006). In the current study, we focused on 3-month-old recuperated rats fed a chow diet that are a similar weight to control offspring. This enabled us to investigate mechanisms mediating the effects of early nutrition on susceptibility to developing diet-induced obesity without the confounding effects of obesity itself. In recent years, leptin has been studied as a key factor involved in programming of obesity risk (Cripps et al., 2009; Bouret et al., 2004). However, we previously showed that programming of increased adiposity is, at least in part, independent of leptin (Cottrell et al., 2011). In the current study, ...
Somewhere around 16106 AGS-EBV cells treated with numerous siRNAs and TSA as explained higher than ended up collected to ascertain EBV copy variety by qPCR as
This paper examines the maternal, household, and health service factors influencing maternal nutrition practices in the context of a large scale maternal, newborn, and child health (MNCH) program in Bangladesh. Data were from a household survey of… ...
'We know that poor diet and faulty genes may influence the development of both, but here we saw the two combine to cause an increased risk of health
Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offsprings bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Womens Survey). Using high-resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross-sectional area, together with the ratio of femoral metaphyseal cross-sectional area to femur length (femoral splaying index). Lower maternal 25-hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross-sectional area and a higher femoral splaying index at 19 weeks gestation [r = -0.16, 95% confidence interval (CI) -0
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of "NTU Repository" with "Academic Hub" to form NTU Scholars.. ...
New York, March 31: Consuming a high-fat diet during pregnancy and lactation may put your offspring at higher risk of obesity later in life, a recent research
Extensive epidemiological evidence in humans and animal models suggests that poor maternal nutrition increases the susceptibility of the offspring to develop ty...
The Womens Health Dietetic Practice Group addresses health and nutrition issues relative to the life stages that are unique to women including preconception, prenatal, postpartum, lactation and menopause.
Poor nutrition during pregnancy is a significant contributor to maternal morbidity and a leading cause of childhood mortality and morbidity worldwide. There is universal recognition of the importance of the The First Thousand Days for physical growth and, when linear growth fails during this window of opportunity, for associated concurrent and future morbidity and mortality [1-3]. Sub-optimal nutrition is widely regarded as the most important etiologic factor contributing to impaired linear growth in poor communities worldwide. However, multiple nutrition interventions, whether maternal following identification of pregnancy, or offspring , 2 years of age have overall met with only partial success [4]. Typically, however, maternal intervention trials have not begun in the first trimester or/and the periconceptional period despite observational evidence of a relationship between poor maternal nutrition at conception and LBW first reported a quarter of a century ago [5]. A series of ...
Augustyniak, R. A., Singh, K., Zeldes, D., Singh, M. & Rossi, N. F. (2010). Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring. American journal of physiology. Regulatory, integrative, and comparative physiology 298(5), 1377-1382. ...
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Hans van Goudoever - Right amount of fat and protein, key to babies The early childhood diet and that of the mother during pregnancy determines the health of a child later life. This is the claim that the EU-funded research project Early Nutrition is trying to substantiate by the time it is due to be completed in 2017. ...
Women with preeclampsia were older than those without it and likelier to be non-Hispanic white, married, more educated, nonsmokers, and overweight when pregnancy began. Adjusted serum 25(OH)D levels in early pregnancy were 15% lower in women who later developed preeclampsia than in control subjects. Maternal serum levels of 25(OH)D below 37.5 nmol/liter in early pregnancy were associated with a 5-fold increase in the risk of developing preeclampsia, independently of race/ethnicity, season of the year, gestational age at sampling, prepregnancy body mass index, and educational level. Adjusting for calcium intake altered the findings only slightly. After adjusting for several possible confounding factors, a 50-nmol/liter decline in serum 25(OH)D more than doubled the risk of preeclampsia. The adjusted odds ratio was 2.4 with a 95% confidence interval of 1.1-5.4. The disparity in maternal vitamin D levels persisted at the time of delivery. Cord blood serum levels of 25(OH)D were significantly lower ...
Malnutrition remains a significant problem among HIV-infected populations, even among those with access to ART. In patients with HIV infection, poor nutritional status is associated with significant reduction in survival rates, accelerated disease progression, diminished response to therapies including ART, increased susceptibility to opportunistic infections, and reduced work capacity and quality of life. However, there is not evidence whether delay or reversal of weight loss improves life expectancy, nor is there evidence about the specific benefits food supplementation has on people with HIV infection. As antiretroviral therapy (ART) services continue to scale up in sub-Saharan Africa, there is a critical need for information about the impacts of appropriate food supplementation on the effectiveness of ART, on the health status of clients, and on the progression of the disease.. Malnourished adult ART and pre-ART clients at six clinical sites in Kenya are randomly allocated either to a group ...
Undernutrition and oxidative stress in fetal life and infancy may lead to adverse health outcomes in the offspring. We studied nutrition and oxidative parameters in pregnancy and their associations with birth anthropometry and metabolic status in the children.. In Matlab in rural Bangladesh, women were randomized to either early (Early) invitation to food supplementation or to start at their own liking (Usual). Women were also allocated to either; 1) 60 mg iron and 400 µg folic acid (Fe60F), 2) multiple micronutrients including 30 mg iron and folic acid (MMS), or 3) 30 mg iron and folic acid (Fe30F). Micronutrients (hemoglobin, iron, zinc, folic acid, vitamin B-12) were assessed in pregnancy week 14, lipid peroxidation in week 14 and 30, and DNA oxidation in week 19. The offspring were assessed for anthropometric measurements at birth and metabolic status at 4.5 years.. Micronutrient deficiencies were common with zinc and vitamin B-12 deficiency being most prevalent. Anemia was present in ...
Prenatal vitamin D status and offsprings growth, adiposity and metabolic health: a systematic review and meta-analysis - Christina Santamaria, Wei Guang Bi, Line Leduc, Negar Tabatabaei, Prévost Jantchou, Zhong-Cheng Luo, François Audibert, Anne Monique Nuyt, Shu Qin Wei
Proximal Constituents 3.8. Generally speaking, it would appear that, except in extreme maternal undernutrition, the concentrations of total energy and protein in breast-milk are maintained at remarkably normal levels. In the Gambia, for example, where even during good times of the year dietary mean intake is only 1,700 kcal/d, the average energy content of the mothers milk is maintained at 72 kcal/100 ml, which compares well with the mean content of British mothers milk, 69 kcal/100 ml. Even when mean intake was 1,100-1,200 kcal/d the energy content only dropped by about 10 per cent. 3.9. It is not easy to be precise about the effect of maternal diet on fat content, because concentration varies during the course of a feed - the fore-milk being more dilute than hind-milk. Most studies have been based on expressed milk, but more cannot be sure that this reproduces the same value that integrated measurements during actual breast-feeding would. In the Gambia, an estimate of the average fat content ...
(2000) Kwong et al. Development. Epidemiological studies have indicated that susceptibility of human adults to hypertension and cardiovascular disease may result from intrauterine growth restriction and low birth weight induced by...
A study team at MedUni Viennas Center for Brain Research has found that high-fat maternal diets can cause life-long changes in the brain of the unborn offspring.
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Epidemiological, clinical, physiological, cellular, and molecular evidence suggests that the origins of obesity and metabolic dysfunction can be traced back to intrauterine life and supports an important role for maternal nutrition prior to and durin
Periconceptional folic acid (FA) has an established protective effect in preventing neural tube defects (NTDs), leading to global recommendations for FA supplementation before and in early pregnancy. However, it is unclear whether there are any benefits for offspring brain health arising from continued maternal FA supplementation beyond the first trimester. The aim of this thesis was to investigate the role of maternal folate nutrition during pregnancy in relation to brain health in the offspring. As part of this work, an extensive review of the literature was conducted which highlighted that maternal folate during pregnancy may affect neurodevelopment and cognitive performance in the first decade of life, albeit the evidence at this time is predominantly observational. The children of mothers who had participated in a randomised trial of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) were investigated, providing a unique opportunity to more robustly examine offspring ...
MONDAY, March 16, 2020 (HealthDay News) - There is an association between low maternal vitamin D during early pregnancy and an elevated risk for offspring attention-deficit/hyperactivity disorder (ADHD), according to a study recently published in the Journal of the American Academy of Child & Adolescent Psychiatry.. Minna Sucksdorff, M.D., from University of Turku in Finland, and colleagues examined the association between maternal 25-hydroxyvitamin D [25(OH)D] levels in early pregnancy and offspring ADHD. The analysis included 1,067 ADHD cases born between 1998 and 1999 and 1,067 matched controls. First-trimester maternal 25(OH)D serum levels were assessed using quantitative immunoassay.. The researchers observed a significant association between decreasing log-transformed maternal 25(OH)D levels and offspring ADHD in unadjusted analyses (odds ratio [OR], 1.65) and in the analyses adjusting for maternal socioeconomic status and age (OR, 1.45). ADHD risk was higher for the lowest versus highest ...
Maternal obesity is associated with dysregulation of glucose and lipid metabolism with consequent exposure of the fetus to an abnormal metabolic milieu. It is recognized that maternal obesity predisposes offspring to chronic kidney disease (CKD). We aimed to determine whether the nuclear Farnesoid X receptor (FXR), known to play a role in maintaining homeostasis of glucose and lipid metabolism, is involved in renal injury in offspring of obese mothers. Maternal obesity was established in a rat model by feeding dams with high-fat diet prior to and during pregnancy and lactation. The offsprings kidneys were examined at postnatal Day 1and Day 20. Human kidney 2 (HK2) cells were exposed to high glucose with or without the FXR agonist GW4064 or when FXR mRNA was silenced. Glucose intolerance in the offspring of obese mothers was evident at weaning, with associated downregulation of renal FXR expression and upregulation of monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor-β1 (TGF-β1
TY - JOUR. T1 - Association of Maternal Obesity with Child Cerebral Palsy or Death. AU - McPherson,Jessica A.. AU - Smid,Marcela C.. AU - Smiley,Sarah. AU - Stamilio,David M.. PY - 2017/5/1. Y1 - 2017/5/1. N2 - Objective The primary aim of this study was to determine if there is an association between maternal obesity and cerebral palsy or death in children. Study Design This is a retrospective cohort analysis of a randomized controlled clinical trial previously performed by the Maternal-Fetal Medicine Units Network. Women in the original trial were included if at high risk for preterm delivery. The present study included singletons enrolled in the original study with complete data. Obese and nonobese women were compared. A secondary analysis comparing class 3 obese or classes 1 to 2 obese women to nonobese women was performed. The primary outcome was a composite of cerebral palsy or perinatal death. Results In this study, 1,261 nonobese, 339 obese, and 69 morbidly obese women were included. ...
Principal Investigator:TOKUDA NOBUKO, Project Period (FY):2011 - 2013, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Eating habits, studies on eating habits
Maternal nutrient restriction at specific gestational stages compromises fetal growth and development, in particular, fetal adipose tissue deposition. The extent to which nutritional supplementation can promote growth and development of specific fetal organs is unknown. This study aimed to determine whether protein supplementation of the maternal diet at defined stages of gestation promoted the abundance of the key mitochondrial proteins; uncoupling protein 1 (UCP1), cytochrome c and the voltage dependent anion channel (VDAC) in fetal adipose tissue.. Twenty-nine twin-bearing ewes of similar body weight and parity were randomly allocated to 4 feeding groups from 10d gestation. All ewes received a control diet, which was supplemented with fishmeal in 3 of the groups during early i.e. 10d-40d, mid i.e. 40d-70d or late i.e. 110d-140d gestation. Each ewe was then humanely euthanased with an overdose of barbiturate (100 mg/kg pentobarbital sodium: Euthanal) at 140d gestation to enable sampling of ...
In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.. ...
The Role of Maternal Nutrition on Oocyte Size and Quality, with Respect to Early Larval Development in The Coral-Eating Starfish, Acanthaster planci. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Most canines have a tendency to regulate very properly to selfmade dog food. Wonderful maternal nutrition prior to and during pregnancy sources of protein are: lean chicken, eggs, sea meals nutritional values green apples tuna, salmon, halibut, cod, and tilapia), lean beef, milk curd and cheese, peanut butter, beans, lentils, hemp, soy, and more. Noda N and Horiuchi Y. This includes the International Journal of Sport Diet, for which youll entry tables of contents from 1995 on, links and a publication. The truth is, even the need to have your physical options corrected in an effort to increase your shallowness can not just simply be thought-about vainness. It took lots efforts and modifications in foods and life-style till he study and applied a full pH balance Diet that made it potential. Medical house name doctor, NJ offers expedient and efficient care in a courteous and compassionate method through advantage of a modern-day medical home call in your NJ residence, workplace or resort. The ...
After taking many high dose forms of Vit. D, my levels continued to drop and went from 22 before taking supplements to 17(even worse). The supplements were also making me very nauseous. I told my doctor (a Rheumatologist as I have Fibromyalgia) that we had to figure out something else to get my D up. I suggested a topical D cream as I know that D can be absorbed through the skin. She called several other professionals and found that there is a sub-lingual (under the tongue) Vitamin D spray available. It is not by prescription, it is online only. Anyway, after using it for a month or so, my levels are up into normal range of 57 with no more nausea! If you are having trouble getting your D level up, I would recommend talking to your doctor about trying the sub-lingual D spray ...
Prenatally programmed hypertension induced by maternal protein restriction is associated with increased expression of the renal tubular Na+/K+/2Cl− co-transporter (NKCC2) and the Na+/Cl− co-transporter (NCC). This has led to the suggestion that renal Na+ retention contributes to the development of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero). However, this hypothesis has not been tested in vivo. Renal clearance measurements in hypertensive 4-week-old male and female LP rats showed that, although the glomerular filtration rate remained unaltered, urine flow (P,0.01) and urinary Na+ excretion rates (1.6±0.3 and 3.0±0.4 μmol·min−1·100 g−1 of body weight in control male and LP male respectively; P,0.001) were increased. Na+ excretion was positively correlated with mean arterial pressure in both males (P,0.01) and females (P,0.05), but neither the slope nor the intercept differed between control and LP rats. Fractional excretion of Na+ was ...
Parasites (or diseases) are major selective force for the evolution of life history traits and parasite-host evolution. Mothers can show a variety of responses to parasites during pregnancy with different consequences for them or their offspring. However, whether information in the maternal environment before pregnancy can cause a change in the phenotype of the offspring is unknown. To avoid the confounding effect of pathogens and to reduce the risk of direct effect of mothers immune activation, we injected female laboratory mice with lipopolysaccharides (LPS) before mating. In order to provide a constant information on the potential infectious risk of the environment, females were mated with males that were also exposed to LPS before mating. Offspring from immune-challenged parents were larger and grew at a faster rate than offspring from control parents (injected with PBS). Additionally, offspring from immune-challenged parents that suffered the most from inflammation grew at a faster rate ...
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We examined the factors influencing maternal food intake and pup growth in Norway rats. Mother rats allowed pups in naturally large litters to grow at a slower rate than pups in naturally small litters. Pups reared by dams in a warm ambience (26 degr
may very well increase the potency of the stimulants, part of the fat loss effects are due to the lowering of taurine. Research shows that Taurine actually reduces insulin sensitivity. This is bad for those trying to lose weight because insulin tolerance leads to more fat gain long term. Taurine also has been shown to lower the thyroid hormone levels, which results in slowing of metabolism. When you reach a fat loss plateau often the thyroid plays a major role in causing it, due to a slowing of metabolism.. ...
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About the Study:. This study builds upon Dr. Waterlands previous research showing that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes in human metastable epialleles, special regions of the genome that are highly sensitive to DNA methylation. To investigate whether these epigenetic changes could be a possible result of a womans nutritional intake even before conception, the researchers conducted 2 different genome-wide surveys in a population of women in Gambia, where changing seasonal availability of food created a natural experiment in which a comparison could be made amongst women who conceived during times of food abundance versus those in times of famine.. A major finding from both surveys showed that VTRNA2-1, a tumor suppressor gene associated with carcinogenesis, is influenced by a womans nutritional intake, and that this influence could contribute to her childs lifetime cancer risk.. In a BCM press release about the study, Dr. ...
National Research Council - consulte a biografia e bibliografia do autor de Cost, Effectiveness And Deployment Of Fuel Economy Technologies For Light-Duty Vehicles, The Growing Gap In Life Expectancy By Income, Overcoming Barriers To Deployment Of Plug-In Electric Vehicles ...