This study indicates that maternal occupational exposure to solvents may be associated with higher rates of ASD in their children. These results should be interpreted with caution given that this association did not remain significant after correcting the P-values for multiple comparisons. However, these results are consistent with earlier reports that have identified solvents as a potential risk factor for ASD.5 9 28 Research in the non-ASD population has found that solvents can be absorbed into the blood via skin or lungs.29 Water-soluble solvents may be cleared out of the body in urine or faeces, but many solvents are retained in organs including the brain. Solvents can also be metabolised into more toxic secondary substances (eg, methyl-butyl ketone, n-hexane) that are associated with a number of neurological effects and changes.29 In infants, solvents have been found to interfere with the glial guidance process which inhibits neuritic outgrowth.30 Infants of mothers who have been exposed to ...

PCBs are industrial chemicals that have neurotoxic effects, and studies indicate that they interfere with normal functions of the endocrine system. Although the manufacturing of PCBs was banned in the 1970s, they remain a major contaminant of the environment and of human tissues. Epidemiological studies show that exposure to PCBs during intrauterine development is highly associated with measurable neurological deficits in the offspring. In addition, deficits associated with PCBs are inversely associated with maternal thyroid hormone (TH) levels. This suggests that PCBs interfere with TH action in the fetal brain. Using in situ hybridization to measure HES-1 and HES-5 mRNA (direct markers of Notch activity), our laboratory has found that both maternal thyroid status and maternal exposure to PCBs influences Notch signaling in the fetal rat brain. We found that Aroclor 1254 produces a dose-dependent increase in HES-1 expression in the ventricular zone. Recent evidence suggests that Notch signaling ...

Andrea Baccarelli and colleagues show that maternal exposure to a dioxin following the industrial accident in Seveso, Italy in 1976 is associated with modified neonatal thyroid function even many years later.

Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.

I am so sorry things arent going well for your dreams for a second child. I just wanted to offer you a little hope, first of all, I have TWO friends who have the same clotting disorder, it must be very common! One of my best college friends had a son, then tried for her 2nd for several years and I think she miscarried at least 5 times or more. She did get pregnant again once they figured things out and she had to give herself shots almost her entire pregnancy, but she was able to keep the baby that time. So I think there are things that can be done?? You should check with your doctor about it if you havent already. Dont give up hope! ;) Ill be praying for you. Also- maybe you know but Kerigan didnt come easy for us, either. We have infertility (different issues, but still just as frustrating), and she took 2 years and several shots/treatments too. Why cant it just be easy?! Especially for good moms and dads who deserve another baby. It is so hard when it doesnt come easy for people like ...

PubMed journal article: Developmental toxicity study of pure trans-capsaicin in rats and rabbits. Download Prime PubMed App to iPhone, iPad, or Android

The study has elaborates the link between increased expressions of autistic-like behaviours in pre-school aged children to gestational exposure to selected environmental toxicants.

Due to an error during production, some data presented in Table 1 in the Experimental section of the published paper [1] were incorrect.[...]

The young age at onset of many cancers in childhood has led to investigations on maternal exposures during pregnancy. Data from a population-based case-control study in Germany (1992-1997) that included 1,867 cases and 2,057 controls was used to investigate this question. Maternal use of vitamin, fo …

5 throughout pregnancy of two.three vs. 1.seven, respectively). The ninety five% CIs were not notably larger In this particular analysis, suggesting that collinearity was not an important difficulty. Also, through pregnancy we discovered the Affiliation to become especially with the third-trimester exposure in products that involved exposure in all trimesters alongside one another. The specificity from the Affiliation for the prenatal period is in line with a number of other lines of proof that propose a prenatal origin of ASD, like data on variances in brain cytoarchitecture in brains of youngsters with ASD (McFadden and Minshew 2013; Stoner et al. 2014) and associations among maternal exposure to teratogens for the duration of pregnancy and ASD (Rodier 1995). Our effects also advise an association predominantly in boys, but this locating ought to be interpreted with warning, given the little number of ladies with ASD inside our sample ...

Maternal exposures to organochlorines prior to pregnancy are considered a risk to neonatal welfare, specifically in relation to neurocognitive functions. There is growing interest in the evaluation of maternal blood testing as a marker for fetal expo

DES placental exposure and temporal changes in gene expression. Analysis of gene expression profiles in rats offspring following DES maternal exposure.

In a study to estimate the relative risk of congenital malformations associated with maternal exposure to organic solvents such as white spirit, mothers of malformed babies were questioned about their contact Table 12-2 in the textbook by Aschengrau and Seageprovides a nice illustration of some of the limitations of p-values. When many possible associations are examined using a criterion of p< 0.05, the probability of finding at least one that meets the critical point increases in proportion to the number of A Scale Whose Smallest Divisions Are In Centimeters In a survey of breast cancer alternative diagnostic criteria were compared with the results of a reference test (biopsy). Outbreaks of disease Chapter 12. Video Summary: Confidence Intervals for Risk Ratio, Odds Ratio, and Rate Ratio (8:35) Link to a transcrip of the video The Importance of Precision With Non-Significant Results The difference between the Biased (systematic) subject variation -Blood pressure is much influenced by the ...

So this is making me feel like a FTM (first time mom) wll over again... even though I know its probably nothing I cant help but be a bit nervous. I havent had spotting this entire pregnancy. DH (dear husband) and I havent had sex recently (or, because of me, hardly ever this pregnancy) so I know its not that. Last night I wiped and noticed some pink/brown discharge. I have not been having cramping other than random BH yesterday during my normal walk in the afternoon. Thr only pain Ive had is RLP and pain in my vagina since shes been sitting so low this whole pregnancy. I have felt her move afterwards, not doing kick counts but it doesnt feel like more or less than normal) I called my OB last night and am waiting to get in for an appointment this morning at her request. Anyone else have the same thing? To be honest whats making me more worried is our LO (little one) PAPP-A result and that I oftrn have pain in my vagina due to babys position

This short sleeve cotton maternity tee is your new go-to essential. Its perfect for layering and wearing anytime and anywhere. Long enough to take you through your entire pregnancy.

Kris- TO answer your question, I am on metformin and synthroid. I had responded when you first posted back in Oct. Im so sorry about your m/c. I do split up my meds and I worked up to 2000mg a day. When I was on 1000 mg, I took one in the am and one in the pm. I did that for a week. THen upped the dose to 1500. I took 2 in the am and 1 at night. Now Im on 2000mg. I have stayed on that through my entire pregnancy. So far my baby is measuring perfect. The thing with metformin is that if you continue to eat crap that upsets your stomach it will tear you up. You have to change how you eat so that it does not bother you ...

AMHERST, Mass. - Some studies indicate that early life exposure to pollutants such as PCBs and phthalates can predispose people to disease. Now environmental scientist Alicia Timme-Laragy at the University of Massachusetts Amherst has received a five-year, $1.7 million grant from the National Institute of Environmental Health Sciences for a multi-level study of early life exposure to environmental contaminants and aberrant pancreas development, which may predispose one to diabetes.. Disease may result from environmental contaminant exposure in early life via oxidative stress, disrupted signaling pathways controlling embryo growth, or via subtle structural or functional changes to insulin-producing pancreatic beta cells, she notes. Results of this work will be relevant to public health officials concerned about such exposures as well as molecular biologists studying signaling pathways to gain a mechanistic understanding of disease processes very early in life.. The researchers will study toxic ...

Public release date: 15-May-2008 ORLANDO, FL, MAY 18, 2008-Higher incidences of congenital anomalies, including cryptorchidism (undescended testicles) and hypos

Maternal exposure to higher levels of air pollution is associated with lower IQ scores in their children. For those whose mothers were in the highest 10% of exposure had IQ score that were, on average, 2.5 points lower than those whose mothers were in the lowest 10%. However, higher maternal folate levels appear to neurtralize the effect of high pollution exposure on offspring. Read More ...

A new study of delivery outcome following maternal use of SSRI antidepressants in earlypregnancy has been conducted utilizing the Swedish national registry data. Previouspublished studies utilizing these registry data, and cited in the previous version of theparoxetine Prescribing Information, found no evidence for an increased overall risk ofmajor malformations with maternal exposure to SSRI medications, including paroxetine(Hallberg 2005, Ericson 1999). In this latest study, the population that was investigatedcomprised infants of 6,896 women exposed to antidepressants in early pregnancy(including 5,175 infants born to 5,123 women reporting the use of any SSRI in the firsttrimester). Among them, 815 women reported the use of paroxetine and they delivered822 infants. Rates of malformations in these infants were compared with the generalpopulation experience. No increase in the overall rate of congenital malformations wasobserved in infants exposed to paroxetine (4.9%), compared with the general ...

Is anyone juicing during their pregnancy? I am 5 weeks pregnant & have been juicing fruits & veggies! I did it before I was pregnant & am containing it during my entire pregnancy. I have noticed a ris...

Prenatal Exposure Delayed Effects: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.

We did not find out what we were having, but we were quite convinced we were having a boy. We had our girl name picked out for basically my entire pregnancy. We decided on our boy name about 2 weeks before my due date and we still werent totally sold on it. She came out a girl, though, so it all worked out! We wanted a biblical name that wasnt weird for the first name and family name for the middle name. My hubby listens to this radio show called Garage Logic and they talk about foghornable names which are weird names, so we couldnt go with anything weird. I also have a pet peeve about common names that are spelled in weird ways, so that was out. Picking a name is really hard! I still dont really like the boy name we had, so whenever #2 comes along i have no idea what we would name him or her!. ReplyDelete ...

Hey all! Long time since Ive been here. I just weaned my 2nd child in January 2012 after 2 years of BF..and had my 3rd child December 7. Ive been exclusively breastfeeding since birth. I pumped some with my 2nd child but dont remember the rules of when or how to pump an occasional bottle. I have a history of a Pulmonary Embolism/Blood Clot that required me to take Heparin injections the entire pregnancy. I must go to the follow up appt around the 5-6 week mark postpartum. The appt is

I had the best 2 hour nap of my life. I seriously hadnt slept this well my entire pregnancy, and I remembered thinking to myself, I hope the nurse doesnt wake me up; I could sleep for another 3 days like this -- maybe we can deliver the baby in three days? It was around 10am at this point, and I told King that Id probably be ready to push around noon (I was 7-8 cm dilated, but babys head was still far up). King thought it would be closer to 3-4pm. The nurse woke me up around 1pm and checked and saw that the baby had descended, and I was fully dilated. So we did our first practice push. At the end of the push, she said to King (who was holding one leg while the nurse had the other leg) See that black part? Thats the top of the babys head. I was really encouraged, I figured, it cant be that far if they can already see the top of the babys head. We did a few more pushes, and I was gaging how it was going based on King & the nurses reactions and expressions. King said to me in Hindi at ...

When I found out that I was pregnant with my first baby, the only thought I had about breastfeeding was Im going to breastfeed and that was it. Simple. I never gave it another thought throughout the entire pregnancy.. But breastfeeding isnt so linear. Its a complex beast thats full of incredible highs and lows. I remember thinking back to my third week of breastfeeding my now 8-month-old son Hudson that breastfeeding is way harder than childbirth itself - and I went through over 20 hours of labour only to end up having an emergency C-Section, but thats a story for another time.. Our nursing journey started off beautifully, with my husband being the person to place our son onto my breast for the first time several hours after my C-section surgery. I was elated that Hudson latched well enough to feed happily. By the third day, my milk had come in and it felt like a surreal high to be able to feed my little boy and soothe him while holding his tiny body up so close against mine. It was, as ...

Once she gets to Childrens, they will do an ultrasound on her to check to make sure all the other internal organs look fine. They will also repeat the fetal echocardiogram to ensure that her heart is strong enough for surgery. She explained that a lot of kids with this issue also have other organ issues, so if they are going to go in and do a repair they want to know ahead of time of any other issues so they can fix them all. An example was to make sure there wasnt any blockage in the esophageal/tracheal region, proper kidney functioning, etc. She said that most of these issues would have already shown themselves on a previous ultrasound, but they will double-check. She also said that sometimes these kids have an extra vertebra or shortened limbs. Im not too considered about the limbs considering this kids limbs have been measuring 2-3 weeks ahead for the entire pregnancy. ...

The level and duration of exposure to nerve gas determines the severity of resulting symptoms and effects. In low amounts, with a short duration of ex

Dr Hure focus is giving children in Australia and around the world the best start to life through optimal nutrition and early life exposures.

TY - JOUR. T1 - Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. AU - Vrijheid, M. AU - Armstrong, B. AU - Dolk, Helen. AU - van Tongeren, M. AU - Botting, B. PY - 2003. Y1 - 2003. U2 - 10.1136/oem.60.8.543. DO - 10.1136/oem.60.8.543. M3 - Article. VL - 60. SP - 543. EP - 550. JO - Occupational and Environmental Medicine. JF - Occupational and Environmental Medicine. SN - 1351-0711. IS - 8. ER - ...

Results Multivariable analysis showed a strong association with potential maternal occupational exposure to heavy metals with an over twofold increased risk of hypospadias (OR 2.6; 95% CI 1.3 to 5.2), and women exposed to phthalates were more likely to have an affected son (OR 1.2; 95% CI 0.8 to 1.7). Compared with mild or isolated cases, the risks of moderate-severe hypospadias or multiple defects were increased up to two- and fivefold, respectively, with maternal exposure to most types of EDCs. Paternal occupational exposures to polychlorinated organic (OR 1.3; 95% CI 1.0 to 1.8) and bi-phenolic (OR 1.6; 95% CI 1.0 to 2.6) compounds were also possible risk factors. ...

Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence. We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006-2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation to specific air pollutant. Both cases and controls were selected from a cohort of 1-million beneficiaries of Taiwans National Health Insurance program registered in 2005. Maternal exposures to mean daily air pollutant concentration, derived from 76 fixed air quality monitoring stations within the 12-week period prior to pregnancy and during the 1st and 2nd trimesters, were assessed by the spatial analyst method (i.e., ordinary kriging) with the ArcGIS software. After controlling for potential confounders and other air pollutants, an increase in pre-pregnancy exposure of 1 inter

The persistence of racial disparities in low birth weight (LBW) and preterm birth (PTB) is one of the most widely documented problems in public health. Most studies of these birth outcomes have focused primarily on maternal exposure to individual-level risk factors during the prenatal period. That research has resulted in only a partial explanation for the observed disparities. My research, therefore, had two primary aims: (1) to examine the relationship between adverse birth outcomes and maternal exposure to family and neighborhood disadvantage during childhood; and (2) to determine the behavioral, psychosocial, and health pathways through which these exposures affect birth outcomes and translate into racial disparities. Data for this research came from Waves I and III of the National Longitudinal Study of Adolescent Health (Add Health). The sample consisted of 500 Black and 1,077 White females who gave birth in late adolescence or young adulthood. I used structural equation modeling to test ...

A study of published work was carried out in a search for evidence of a causal role for parental occupational exposure in the origin of structural and functional defects of the central nervous system (CNS) in children. Studies that consider this topic are scarce and mostly refer to broad categories of exposures and effects. Non-occupational studies referring to environmental exposure of humans and studies on experimental animals were also reviewed. The studies on animals provided straightforward evidence about morphological and behavioural abnormalities resulting from some agents used occupationally. The studies on humans yielded a scala of defects that could be ascribed to exposure to high doses of various agents in the environment. Evidence for a causal role of occupational exposure has not been found, but a highly probable influence on the developing CNS is hypothesised for lead, methyl mercury, and ionising radiation. Parental occupational exposure to cadmium, organic solvents, anaesthetics, ...

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John:. I and other community members are still concerned about chemical exposures to all Kipp factory workers, especially women who are or could become pregnant.. As far as VOCs and exposures via vapor intrusion, TCE is of particular concern because it is more toxic than PCE-it is a carcinogen and also causes neurological, immune system, kidney, liver, reproductive, and developmental effects. Many of the effects from fetal exposures may not show up until adulthood. Vapor intrusion screening levels for TCE are much lower than for PCE-see here.** Also, recently government risk assessors concluded that the weight of evidence indicates that TCE and/or its metabolites could cause cardiac defects in fetuses even if maternal exposure durations are short, one-time, and relatively low dose. Below my name, I pasted a summary from an EPA TCE risk assessment document re TCE and heart defects. You can find the IRIS info on TCE toxicity here and here.. We know Kipp used TCE as well as PCE at least into the ...

1 Jamal, A., Agaku, I. T., OConnor, E., King, B. A., Kenemer, J. B., & Neff, L. (2014). Current cigarette smoking among adults-United States, 2005-2013. MMWR Morb Mortal Wkly Rep, 63(47), 1108-1112.. 2 Centers for Disease Control and Prevention. (2016). Current Cigarette Smoking Among Adults in the United States.. 3 Pineles, B. L., Park, E., & Samet, J. M. (2014). Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. American journal of epidemiology, 179(7), 807-823.. 4 Centers for Disease and Control. (2015). Highlights: Impact on Unborn Babies, Infants, Children, and Adolescents.. 5 Cnattingius, S. (2004). The epidemiology of smoking during pregnancy: smoking prevalence, maternal characteristics, and pregnancy outcomes.Nicotine & Tobacco Research, 6(Suppl 2), S125-S140.. 6 Centers for Disease Control and Prevention (2016). How Does Smoking During Pregnancy Harm My Health and My Baby?. 7 American College of Obstetricians and Gynecologists. ...

While increasing evidence suggests that maternal exposure to high levels of ambient air pollutants during pregnancy plays a critical role in producing adverse p...

2020 Elsevier LtdThe patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. ...

PracticeUpdate® is a registered trademark of Elsevier Inc. Copyright © 2021 Elsevier Inc. All rights reserved.. Download My Dashboard by PracticeUpdate for easier access on your mobile device.. We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. Cookie Settings. ...

You said something that, to be honest, really chilled us.You said you would be there for us should we (Kim specifically) ever require an abortion. We loved all five of our children well before they were born, throughout our entire pregnancies. Birth didnt change them genetically or inherently, it simply brought them into our full view. You might have extended us an offer to euthanize our toddlers should they become too much of a burden financially, physically or psychologically, and our reaction would have been exactly the same. To one who loves her child from conception onward, there is no distinction. So your offer was lost on us, as we would never deny our own children, whether they sleep safely in our womb or in a crib. You may believe that every woman would submit to an abortion if the circumstances were right, but you would be wrong. And how much more loving and civilized it would have been had you offered to help us with an adoption instead. There are families waiting to adopt every ...

You said something that, to be honest, really chilled us.You said you would be there for us should we (Kim specifically) ever require an abortion. We loved all five of our children well before they were born, throughout our entire pregnancies. Birth didnt change them genetically or inherently, it simply brought them into our full view. You might have extended us an offer to euthanize our toddlers should they become too much of a burden financially, physically or psychologically, and our reaction would have been exactly the same. To one who loves her child from conception onward, there is no distinction. So your offer was lost on us, as we would never deny our own children, whether they sleep safely in our womb or in a crib. You may believe that every woman would submit to an abortion if the circumstances were right, but you would be wrong. And how much more loving and civilized it would have been had you offered to help us with an adoption instead. There are families waiting to adopt every ...

Being in the hospital this past week has really forced me to acknowledge the fact that these babies have to come out and not by a wave of a magic wand. This is the part that i have been dreading the most. This entire pregnancy I tried not focusing on the delivery and just on the joy of having my babies in my arms and being a mom. Well now all I think about are these contractions and the big delivery. Honestly its all very daunting to me. I havent committed to a c-section or a vaginal delivery. I get mixed opinions on both and its a lot to consider. With a cesarean I worry about the recovery, the pain of nursing two babies and an incision, not to mention a scar. With vaginally I worry about putting my babies in distress or going through all of the labor and then needing an emergency cesarean anyway. I also worry that if the babies are in position for me to deliver naturally and I choose cesarean then I will regret not trying. My doctor is great, he said that if the babies heart rates look ...

Being in the hospital this past week has really forced me to acknowledge the fact that these babies have to come out and not by a wave of a magic wand. This is the part that i have been dreading the most. This entire pregnancy I tried not focusing on the delivery and just on the joy of having my babies in my arms and being a mom. Well now all I think about are these contractions and the big delivery. Honestly its all very daunting to me. I havent committed to a c-section or a vaginal delivery. I get mixed opinions on both and its a lot to consider. With a cesarean I worry about the recovery, the pain of nursing two babies and an incision, not to mention a scar. With vaginally I worry about putting my babies in distress or going through all of the labor and then needing an emergency cesarean anyway. I also worry that if the babies are in position for me to deliver naturally and I choose cesarean then I will regret not trying. My doctor is great, he said that if the babies heart rates look ...

RISK AND REALITY: THE IMPLICATIONS OF PRENATAL EXPOSURE TO ALCOHOL AND OTHER DRUGS By Joanne P. Brady, Marc Posner, Cynthia Lang and Michael J. Rosati The Education Development Center, Inc. 1994.

Part of what I offer as a labor doula is being available to you by phone or e-mail throughout your entire pregnancy! Learn More. Continuous Labor Care. I can join you when labor begins or when you get to active labor, whether you are birthing at home or in the hospital. During this time I will be there to assist with comfort measures in a https://dsmblessedbeginnings.com/ ...

Hey everyone... So, I went to the doc yesterday. They were really nice and she listened to everything from the very beginning. She said that it could still possibly be hemrroids (I dont believe that one), but she said since the prednisone did improve my symptoms that its indictive of inflammation. They really dont want to do a colonoscopy until after I deliver, so they are going to start me on cesena (spelling???) Its a suppository.... Im really nervous, but she said it comes with directions and everything. So my pharmacy ordered it, and it should get here by Friday. She also wants me to ween off the prednisone in the next two weeks, which Im super glad for cuz I wasnt comfortable being on it anyway. She said if the cesena works theyll keep me on that for the entire pregnancy and then do the colonoscopy. If it doesnt work, theyll do a flexiscope, I think she said, in the doctors office. She said it could be Crohns with my family history, but they arent entirely sure. So, they are ...

The other night my honey and I were watching a medical documentary-type show. On it was a young married couple who already had their fair share of hills to climb.. the husband was fighting overseas and the young wife was pregnant. She had been without her husband throughout her entire pregnancy, and their unborn baby…

Sigma-Aldrich offers abstracts and full-text articles by [Ronit Avitsur, Sigal Levy, Rachel Grinshpahet, Naama Goren, Ofer Hirsh, Assaf Zalko].

The goal of the National Birth Defects Prevention Study (NBDPS), an ongoing multi-site case-control study, is to identify environmental and genetic risk factors for birth defects. Information on environmental risk factors is collected through an hour-long maternal interview, and DNA is collected from the infant and both parents for evaluation of genetic risk factors. Clinical data on infants are reviewed by clinical geneticists to ensure they meet the detailed case definitions developed specifically for the study. To standardize the methods of case classification for the study, an algorithm has been developed to guide NBDPS clinical geneticists in this process. ...

CDC works to identify causes of birth defects and opportunities to prevent them. By applying a public health approach incorporating three essential elements-surveillance or disease tracking, research to identify causes, and prevention research and programs-we can rapidly translate scientific findings into appropriate public health interventions.

(R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source of ketones, which may be utilized for energy. In a 28-day toxicity study, Crl:WI (Wistar) rats received diets containing, as 30% of the calories, ketone monoester (12 and 15 g/kg body weight/day for male and female rats, respectively). Control groups received either carbohydrate- or fat-based diets. Rats in the test group consumed less feed and gained less weight than control animals; similar findings have been documented in studies of ketogenic diets. Between-group differences were noted in selected hematology, coagulation, and serum chemistry parameters; however, values were within normal physiological ranges and/or were not accompanied by other changes indicative of toxicity. Upon gross and microscopic evaluation, there were no findings associated with the ketone monoester. In a developmental toxicity study, pregnant Crl:WI (Han) rats were administered 2g/kg body weight/day ketone monoester or water

Hakenewerth, Anne M.; Millikan, Robert C.; Rusyn, Ivan; Herring, Amy H.; Weissler, Mark C.; Funkhouser, William K.; North, Kari E.; Barnholtz-Sloan, Jill S.; & Olshan, Andrew F. (2013). Effects of Polymorphisms in Alcohol Metabolism and Oxidative Stress Genes on Survival from Head and Neck Cancer. Cancer Epidemiology, 37(4), 479-91. PMCID: PMC3725265. Harmon, Quaker E.; Engel, Stephanie M.; Olshan, Andrew F.; Moran, Thomas; Stuebe, Alison M.; Luo, Jingchun; Wu, Michael C.; & Avery, Christy L. (2013). Association of Polymorphisms in Natural Killer Cell-Related Genes with Preterm Birth. American Journal of Epidemiology, 178(8), 1208-18. PMCID: PMC3792727. Lin, Shao; Herdt-Losavio, Michele L.; Chapman, Bonnie R.; Munsie, Jean-Pierre; Olshan, Andrew F.; Druschel, Charlotte M.; & Study, The National Birth Defects Prevention. (2013). Maternal Occupation and the Risk of Major Birth Defects: A Follow-up Analysis from the National Birth Defects Prevention Study. International Journal of Hygiene and ...

Some studies have noted an association between maternal occupational exposures to chlorinated solvents and birth defects in offspring, but data are lacking on the potential impact of industrial air emissions of these solvents on birth defects. With data from the Texas Birth Defects Registry for births occurring in 1996-2008, we examined the relation between maternal residential proximity to industrial air releases of chlorinated solvents and birth defects in offspring of 60,613 case-mothers and 244,927 control-mothers. Maternal residential exposures to solvent emissions were estimated with metrics that took into account residential distances to industrial sources and annual amounts of chemicals released. Logistic regression was used to generate odds ratios and 95% confidence intervals for the associations between residential proximity to emissions of 14 chlorinated solvents and selected birth defects, including neural tube, oral cleft, limb deficiency, and congenital heart defects. All risk estimates

TY - JOUR. T1 - Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk among female offspring. AU - Davis, Jennifer. AU - Khan, Galam. AU - Martin, Mary. AU - Hilakivi-Clarke, Leena. PY - 2013/1/1. Y1 - 2013/1/1. N2 - Background: Since heavy metal cadmium is an endocrine disrupting chemical, we investigated whether maternal exposure to cadmium during the pregnancy alters mammary tumorigenesis among female offspring. Methods: From gestation day 10 to day 19, pregnant rat dams were fed modified American Institute of Nutrition (AIN93G) diet containing 39% energy from fat (baseline diet), or the baseline diet containing moderate (75 μg/kg of feed) or high (150 μg/kg) cadmium levels. Some dams were injected with 10 μg 17β-estradiol (E2) daily between gestation days 10 and 19. Results: Rats exposed to a moderate cadmium dose in utero were heavier and exhibited accelerated puberty onset. Both moderate and high cadmium dose led to increased circulating testosterone ...

In the study, maternal exposure to 10 micro g/ml of BPA in mice enhanced the allergic sensitization and bronchial inflammation and responsiveness in their pups. This dosage mimics the human BPA burden of chronic exposure, including that of pregnant women.. Previous studies indicated that maternal exposure in mice to environmental BPA enhanced the susceptibility of their pups to allergic asthma, said study co-author Terumi Midoro-Horiuti, MD, PhD. The goal of this study was to determine the actual threshold of the effects of BPA on allergic sensitization, airway inflammation and hyper-responsiveness.. Female mice received 0, 0.1, 1 and 10 micro g/ml of BPA in their drinking water from one week before pregnancy, during pregnancy and while nursing their pups, in the study conducted at The University of Texas Medical Branch at Galveston.. BPA is a chemical commonly found in polycarbonate plastic bottles and the aluminum lining of food and beverage cans. BPA production started about 40 years ago. ...

The mind‐derived neurotrophic factor (BDNF)‐tyrosine kinase B (TrkB) (BDNF‐TrkB) signalling pathway plays a crucial part in regulating learning and memory. offspring hippocampus cells using actual‐time PCR (RT‐PCR) and immunohistochemistry (IHC) respectively. The levels of phosphorylated‐TrkB (phospho‐TrkB) and synaptophysin were measured by western blot. It was discovered that maternal exposure NSC-207895 to propofol on day time E18 impaired spatial learning and memory space of rat offspring decreased mRNA and protein levels of BDNF and TrkB and decreased the levels of both phospho‐TrkB and synaptophysin in the hippocampus. Furthermore the TrkB agonist 7 8 (7 8 reversed all the observed changes. Treatment with 7 8 experienced no significant effects within the offspring that were not exposed to propofol. The results herein indicate that maternal exposure to propofol during the late stages of pregnancy impairs spatial learning and memory space of offspring by disturbing the ...

Nearly 80 percent of infant leukemias present with an abnormality involving the MLL gene at 11q23. Moreover, secondary acute myeloid leukemias (AML) that occur as the result of chemotherapy agents, which are known to inhibit DNA topoisomerase II, often manifest the same MLL abnormalities. It has bee …

Egg defence against bacterial contamination relies on immunoglobulins (IgY) concentrated in the yolk and antimicrobial peptides/proteins predominantly localized in the egg white (EW). Hens contaminated with pathogenic microorganisms export specific IgYs to the egg (adaptative immunity). No evidence of such regulation has been reported for the antimicrobial peptides/proteins (innate immunity) which are preventively secreted by the hen oviduct and are active against a large range of microbes. We investigated whether the egg innate defences can be stimulated by the environmental microbial contamination by comparing the antimicrobial activity of EW of hens raised in three extreme breeding conditions: Germ-free (GF), Specific Pathogen Free (SPF) and Conventional (C) hens. The difference in the immunological status of GF, SPF and C hens was confirmed by the high stimulation of IL-1β, IL-8 and TLR4 genes in the intestine of C and SPF groups. EW from C and SPF groups demonstrated higher inhibitory effect

Early Life Exposure to Poor Nutrition and Infectious Diseases and Its Effects on the Health of Older Puerto Rican Adults - Radioc ...

Objectives This paper presents the results of a pilot study of the job-specific modules developed for use in the study questionnaire of the Northern California Childhood Leukemia Study (i) to estimate the variability in response between people administered the same module and (ii) to estimate the number of modules required per family.. Methods For 63 participants in the pilot study, between-person variability was assessed by comparing reported job tasks among the respondents administered the same job-specific module. Within-respondent variability was assessed by examining changes in the timing and frequency of the job tasks and product use across critical time segments from 12 months before the childs birth to 3 years of age. Parental occupational histories were reviewed to estimate the expected number of job-specific modules required per family.. Results Considerable variability was identified for the tasks performed by the respondents with similar jobs and in the timing of tasks and products ...

Maternal exposure to higher levels of air pollution is associated with lower IQ scores in their children. For those whose mothers were in the highest 10% of exposure had IQ score that were, on average, 2.5 points lower than those whose mothers were in the lowest 10%. However, higher maternal folate levels appear to neurtralize the effect of high pollution exposure on offspring. Read More ...

BACKGROUND: Improving operating room safety and efficiency has received much attention over the past decade. This however has been relatively minimally translated into labor and delivery operating suites. In our academic practice, we have noted that prolonged delays in surgical start times may significantly contribute to sooner anesthetic ware and subsequent maternal exposure to supplemental anesthetics/analgesics. Within the context of improving both safety and efficiency, we sought to evaluate the average time interval between intrathecal anesthetic placement and surgical start. OBJECTIVE: Evaluate the average time between placement of intrathecal anesthetic to surgical incision during routine cesarean section. Secondary objectives included: (1) the frequency of supplemental anesthetic adjuncts utilized, in reference to both anesthetic technique as well as intra-operative times, and (2) the evaluation of neonatal outcomes based upon Apgar scoring at 1 and 5 minutes. METHODS: Retrospective ...

Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) and Seveso Womens Health Studies (SWHS) similarities: 1. Both are prospective cohort studies of more highly exposed populations; 2. Both use biomarkers of exposure; and, 3. Both study multiple health outcomes. CHAMACOS and SWHS differences: 1. CHAMACOS focuses on childrens health, SWHS focuses on womens health. 2. CH

Health, ...Irvine Calif. Young adults whose mothers experienced psychological t...The researchers discovered that this prenatal exposure to stress affec... Our previous research on prenatal stress exposure has shown its effec...Study participants were healthy 25-year-old women and men born to moth...,UCI-led,study,links,prenatal,exposure,to,stress,with,accelerated,cell,aging,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

One thing I learned during pregnancy is just how hard Ive always been on myself about my body. Ive spent my life, as far back as I can remember, not loving my appearance.. Even at my most fit I wasnt happy. Before I got married I worked out like a mad woman and got in the best shape of my life. The seamstress altering my wedding dress told me if I lost any more weight that my dress would fall off, so I was forced to stop 5 pounds from my goal weight. Therefore, I never really even enjoyed the hot body Id worked so hard for, because all I could focus on was that 5 pounds that got away.. I knew going into pregnancy that Id be prone to feeling really awful about myself if I didnt take action against it. I started out a good 20+ pounds over my ideal and purposely avoided committing the number on the scale at the start of each appointment to memory. My doctor, bless her heart, never mentioned my weight the entire pregnancy. I essentially just decided from the beginning that I wasnt going to ...

Did you worry the entire pregnancy about the outcome? What helped you calm down and stop the constant worry? It took me until Marisa was about 19 months old and classified as all caught up to even think of getting pregnant again. I was so terrified that if I got pregnant too soon that I wouldnt be able to give her the attention that she needed to catch up. Then of course I had so many uneventful months of trying new doctors and techniques that I had time to get mentally ready for this pregnancy. And then I still wasnt sure if I was ready. My husband didnt even think about bonding with the baby until after my u/s at 19 weeks, and it took me until I got into my second trimester to do much bonding for fear of getting losing this pregnancy.. When I passed the point where the girls were born and I did find a calming factor. Besides in comparison to their pregnancy, this one has been perfect! I feel that having a 36-week preemie was such a joy in comparison to 24 weekers, birth/death experience! ...

Im so sorry for your loss. I know how painful it is to loose baby. Its very good you decided not to give up and look for solutions. I was diagnosed with glomerulonephritis after the birth of my first child. The entire pregnancy I had preeclampsia and hematuria, but not a single gynecologist didnt consider to send me to a nephrologist. When my son was 2 years old Ive got pregnant again. I thought if I could carry my baby once, I can do this again. I was very careful, I tried to nervous less, I quitted my job. I had a diet, nothing spicy and no salt, only healthy food. At the beginning of pregnancy the protein was 0.33 and the pressure was 120/80. Everything seemed to be fine. At 25th week of pregnancy the situation changed completely. The protein was 6-7 and the pressure 230/100. I felt that the child almost didnt move. Doctors told to do an abortion. A cesarean section was urgently made. My second son was born with a weight of 540 grams and had lived for only 2 days. Ive almost lost my ...

I recently gave birth to a beautiful baby girl. My entire pregnancy was so incredible -- I loved every minute of it! I never thought for one minute that my baby could have anything wrong with her. But alas, she was born with a hand deformity that was not diagnosed in utero. I cried non-stop for days. My husband would come home from work and cry with me, hold me while I sobbed, Why our baby? While I know that this hand deformity will not stop her from becoming an amazing person, amazing daughter, I know she will struggle because of it. I wish it was my hand, not hers that was deformed. I wish I could take back whatever I did wrong during my pregnancy. I wish so many things ...

During my first pregnancy I developed severe PIH and eclampsia. My husband and I are thinking about getting pregnant again at the end of this year and Im wondering if I should go to a high-risk OB/GYN or continue to see my current OB/GYN. My family is extremely concerned that my current doctor didnt see the signs of my condition much earlier, even though I showed no signs of preclampsia throughout my entire pregnancy until my 32 week. Please advise if I should go to a high-risk doctor and if so, do I ask for a recommendation from my current doctor? Thanks, in advance ...

Hi everyone. I am 8 weeks with my first (hopefully our rainbow) and am really leaning towards going unassisted for my entire pregnancy. I have never had a good experience with western medicine, and at the one OB appointment I have had so far, even though the doc was very kind and natural-birth minded, I still could not shake the feeling of being so very unempowered in his presence. I would go with a midwife but I am concerned about the out of pocket expenses as we are young and our insurance would cover very little. My fiance is, understandably, not so keen on the idea, as he feels we do not have the experience to birth unassisted our first go around. I, however, feel pretty confident with my bodys ability to birth. Does anyone have any stories/advice/encouragement for a FTM (first time mom) considering UC? Thank you all.

Flanagan EGibson PRWright EKMoore GTSparrow MPConnell WKamm MABegun JChristensen BDe Cruz PShelton EDowling DAndrews JMBrown SJNiewiadomski OWard MGRosella ORosella GKiburg KVRoss ALBell SJ. Infliximab, adalimumab and vedolizumab concentrations across pregnancy and vedolizumab concentrations in infants following intrauterine exposure. Alimentary Pharmacology and Therapeutics. 2020 ...

Humans are exposed to various environmental or dietary molecules that can attenuate or even increase the effect of therapeutic drugs. Studies on the industrial chemical bisphenol A and the phytoes ...

Pollution Worsens Obesity Epidemic. A new study shows that fetal and early life exposure to environmental toxins, oftentimes consumed by the mother as part of her diet, are adequate to induce excess fat storage in a baby. - PR11013732

The history of advances in the understanding of the toxic effects of lead over the past 20 years is an outstanding example of how knowledge learned from research can impact public health. Measures that have had the greatest impact on reducing exposur

The Exposure Assessment Section (EAS) investigates human exposure to chemical or biological hazards in the environment. We evaluate how exposures affect health and how we can reduce harmful exposures ...

เพิ่ม DIBP ในรายการ Phthalate . ใหม่นี้ แปลกกว่าข้ออื่นที่คุ้นเคยกันคือ เป็นข้อห้ามรายการเก่า (รายการที่ 51) ซึ่งเดิมมีพธาเลท 3 ชนิด ...