We appreciate the interest of Dr. Garlant zec et al in our article on the association between maternal occupational exposure to organic solvents (chlorinated, aromatic and Stoddard) and birth defects1 We reported a positive association between chlorinated solvents and neural tube defects, particularly spina bifida; we did not observe an association between solvent exposure and orofacial clefts. As
Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring ...
Is Maternal Exposure During Pregnancy a common side effect of Zoloft? View Maternal Exposure During Pregnancy Zoloft side effect risks. Male, weighting 1.10 lb, was diagnosed with psychotic disorder and took Zoloft 50 Mg, Daily. Patient was hospitalized.
Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2.5) correlates to abnormal fetal development. In the present study, we therefore assessed whether maternal exposure to diesel exhaust PM2.5 (DEP), the major component of ambient PM2.5 in urban areas, programs offspring energy metabolism, and further examined how the timing of exposure impacts this programming. The growth trajectory of offspring shows that although prenatal maternal exposure to DEP did not impact the birth weight of offspring, it significantly decreased offspring body weight from
Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2.5) correlates to abnormal fetal development. In the present study, we therefore assessed whether maternal exposure to diesel exhaust PM2.5 (DEP), the major component of ambient PM2.5 in urban areas, programs offspring energy metabolism, and further examined how the timing of exposure impacts this programming. The growth trajectory of offspring shows that although prenatal maternal exposure to DEP did not impact the birth weight of offspring, it significantly decreased offspring body weight from
Effects of maternal exposure to vehicle or indomethacin (0.8 mg/kg/day; e15.5-e18.5) on testis weight (A), and penis length (B) at Pnd25 and Pnd75 (adulthood)
New research shows that maternal exposure to a common and ubiquitous form of industrial pollution can harm the immune system of offspring and that this injury is passed along to subsequent generations, weakening the bodys defenses against infections such as the influenza virus.
This study indicates that maternal occupational exposure to solvents may be associated with higher rates of ASD in their children. These results should be interpreted with caution given that this association did not remain significant after correcting the P-values for multiple comparisons. However, these results are consistent with earlier reports that have identified solvents as a potential risk factor for ASD.5 9 28 Research in the non-ASD population has found that solvents can be absorbed into the blood via skin or lungs.29 Water-soluble solvents may be cleared out of the body in urine or faeces, but many solvents are retained in organs including the brain. Solvents can also be metabolised into more toxic secondary substances (eg, methyl-butyl ketone, n-hexane) that are associated with a number of neurological effects and changes.29 In infants, solvents have been found to interfere with the glial guidance process which inhibits neuritic outgrowth.30 Infants of mothers who have been exposed to ...
PCBs are industrial chemicals that have neurotoxic effects, and studies indicate that they interfere with normal functions of the endocrine system. Although the manufacturing of PCBs was banned in the 1970s, they remain a major contaminant of the environment and of human tissues. Epidemiological studies show that exposure to PCBs during intrauterine development is highly associated with measurable neurological deficits in the offspring. In addition, deficits associated with PCBs are inversely associated with maternal thyroid hormone (TH) levels. This suggests that PCBs interfere with TH action in the fetal brain. Using in situ hybridization to measure HES-1 and HES-5 mRNA (direct markers of Notch activity), our laboratory has found that both maternal thyroid status and maternal exposure to PCBs influences Notch signaling in the fetal rat brain. We found that Aroclor 1254 produces a dose-dependent increase in HES-1 expression in the ventricular zone. Recent evidence suggests that Notch signaling ...
Andrea Baccarelli and colleagues show that maternal exposure to a dioxin following the industrial accident in Seveso, Italy in 1976 is associated with modified neonatal thyroid function even many years later.
Due to an error during production, some data presented in Table 1 in the Experimental section of the published paper [1] were incorrect.[...]
5 throughout pregnancy of two.three vs. 1.seven, respectively). The ninety five% CIs were not notably larger In this particular analysis, suggesting that collinearity was not an important difficulty. Also, through pregnancy we discovered the Affiliation to become especially with the third-trimester exposure in products that involved exposure in all trimesters alongside one another. The specificity from the Affiliation for the prenatal period is in line with a number of other lines of proof that propose a prenatal origin of ASD, like data on variances in brain cytoarchitecture in brains of youngsters with ASD (McFadden and Minshew 2013; Stoner et al. 2014) and associations among maternal exposure to teratogens for the duration of pregnancy and ASD (Rodier 1995). Our effects also advise an association predominantly in boys, but this locating ought to be interpreted with warning, given the little number of ladies with ASD inside our sample ...
Maternal exposures to organochlorines prior to pregnancy are considered a risk to neonatal welfare, specifically in relation to neurocognitive functions. There is growing interest in the evaluation of maternal blood testing as a marker for fetal expo
DES placental exposure and temporal changes in gene expression. Analysis of gene expression profiles in rats offspring following DES maternal exposure.
In a study to estimate the relative risk of congenital malformations associated with maternal exposure to organic solvents such as white spirit, mothers of malformed babies were questioned about their contact Table 12-2 in the textbook by Aschengrau and Seageprovides a nice illustration of some of the limitations of p-values. When many possible associations are examined using a criterion of p< 0.05, the probability of finding at least one that meets the critical point increases in proportion to the number of A Scale Whose Smallest Divisions Are In Centimeters In a survey of breast cancer alternative diagnostic criteria were compared with the results of a reference test (biopsy). Outbreaks of disease Chapter 12. Video Summary: Confidence Intervals for Risk Ratio, Odds Ratio, and Rate Ratio (8:35) Link to a transcrip of the video The Importance of Precision With "Non-Significant" Results The difference between the Biased (systematic) subject variation -Blood pressure is much influenced by the ...
So this is making me feel like a FTM (first time mom) wll over again... even though I know its probably nothing I cant help but be a bit nervous. I havent had spotting this entire pregnancy. DH (dear husband) and I havent had sex recently (or, because of me, hardly ever this pregnancy) so I know its not that. Last night I wiped and noticed some pink/brown discharge. I have not been having cramping other than random BH yesterday during my normal walk in the afternoon. Thr only pain Ive had is RLP and pain in my vagina since shes been sitting so low this whole pregnancy. I have felt her move afterwards, not doing kick counts but it doesnt feel like more or less than normal) I called my OB last night and am waiting to get in for an appointment this morning at her request. Anyone else have the same thing? To be honest whats making me more worried is our LO (little one) PAPP-A result and that I oftrn have pain in my vagina due to babys position
This short sleeve cotton maternity tee is your new go-to essential. Its perfect for layering and wearing anytime and anywhere. Long enough to take you through your entire pregnancy.
Kris- TO answer your question, I am on metformin and synthroid. I had responded when you first posted back in Oct. Im so sorry about your m/c. I do split up my meds and I worked up to 2000mg a day. When I was on 1000 mg, I took one in the am and one in the pm. I did that for a week. THen upped the dose to 1500. I took 2 in the am and 1 at night. Now Im on 2000mg. I have stayed on that through my entire pregnancy. So far my baby is measuring perfect. The thing with metformin is that if you continue to eat crap that upsets your stomach it will tear you up. You have to change how you eat so that it does not bother you ...
AMHERST, Mass. - Some studies indicate that early life exposure to pollutants such as PCBs and phthalates can predispose people to disease. Now environmental scientist Alicia Timme-Laragy at the University of Massachusetts Amherst has received a five-year, $1.7 million grant from the National Institute of Environmental Health Sciences for a multi-level study of early life exposure to environmental contaminants and aberrant pancreas development, which may predispose one to diabetes.. Disease may result from environmental contaminant exposure in early life via oxidative stress, disrupted signaling pathways controlling embryo growth, or via subtle structural or functional changes to insulin-producing pancreatic beta cells, she notes. Results of this work will be relevant to public health officials concerned about such exposures as well as molecular biologists studying signaling pathways to gain a mechanistic understanding of disease processes very early in life.. The researchers will study toxic ...
Prenatal Exposure Delayed Effects: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
We did not find out what we were having, but we were quite convinced we were having a boy. We had our girl name picked out for basically my entire pregnancy. We decided on our boy name about 2 weeks before my due date and we still werent totally sold on it. She came out a girl, though, so it all worked out! We wanted a biblical name that wasnt weird for the first name and family name for the middle name. My hubby listens to this radio show called Garage Logic and they talk about foghornable names which are weird names, so we couldnt go with anything weird. I also have a pet peeve about common names that are spelled in weird ways, so that was out. Picking a name is really hard! I still dont really like the boy name we had, so whenever #2 comes along i have no idea what we would name him or her!. ReplyDelete ...
Hey all! Long time since Ive been here. I just weaned my 2nd child in January 2012 after 2 years of BF..and had my 3rd child December 7. Ive been exclusively breastfeeding since birth. I pumped some with my 2nd child but dont remember the rules of when or how to pump an occasional bottle. I have a history of a Pulmonary Embolism/Blood Clot that required me to take Heparin injections the entire pregnancy. I must go to the follow up appt around the 5-6 week mark postpartum. The appt is
I had the best 2 hour nap of my life. I seriously hadnt slept this well my entire pregnancy, and I remembered thinking to myself, I hope the nurse doesnt wake me up; I could sleep for another 3 days like this -- maybe we can deliver the baby in three days? It was around 10am at this point, and I told King that Id probably be ready to push around noon (I was 7-8 cm dilated, but babys head was still far up). King thought it would be closer to 3-4pm. The nurse woke me up around 1pm and checked and saw that the baby had descended, and I was fully dilated. So we did our first practice push. At the end of the push, she said to King (who was holding one leg while the nurse had the other leg) See that black part? Thats the top of the babys head. I was really encouraged, I figured, it cant be that far if they can already see the top of the babys head. We did a few more pushes, and I was gaging how it was going based on King & the nurses reactions and expressions. King said to me in Hindi at ...
Once she gets to Childrens, they will do an ultrasound on her to check to make sure all the other internal organs look fine. They will also repeat the fetal echocardiogram to ensure that her heart is strong enough for surgery. She explained that a lot of kids with this issue also have other organ issues, so if they are going to go in and do a repair they want to know ahead of time of any other issues so they can fix them all. An example was to make sure there wasnt any blockage in the esophageal/tracheal region, proper kidney functioning, etc. She said that most of these issues would have already shown themselves on a previous ultrasound, but they will double-check. She also said that sometimes these kids have an extra vertebra or shortened limbs. Im not too considered about the limbs considering this kids limbs have been measuring 2-3 weeks ahead for the entire pregnancy. ...
Dr Hure focus is giving children in Australia and around the world the best start to life through optimal nutrition and early life exposures.
TY - JOUR. T1 - Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. AU - Vrijheid, M. AU - Armstrong, B. AU - Dolk, Helen. AU - van Tongeren, M. AU - Botting, B. PY - 2003. Y1 - 2003. U2 - 10.1136/oem.60.8.543. DO - 10.1136/oem.60.8.543. M3 - Article. VL - 60. SP - 543. EP - 550. JO - Occupational and Environmental Medicine. JF - Occupational and Environmental Medicine. SN - 1351-0711. IS - 8. ER - ...
Results Multivariable analysis showed a strong association with potential maternal occupational exposure to heavy metals with an over twofold increased risk of hypospadias (OR 2.6; 95% CI 1.3 to 5.2), and women exposed to phthalates were more likely to have an affected son (OR 1.2; 95% CI 0.8 to 1.7). Compared with mild or isolated cases, the risks of moderate-severe hypospadias or multiple defects were increased up to two- and fivefold, respectively, with maternal exposure to most types of EDCs. Paternal occupational exposures to polychlorinated organic (OR 1.3; 95% CI 1.0 to 1.8) and bi-phenolic (OR 1.6; 95% CI 1.0 to 2.6) compounds were also possible risk factors. ...
Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence. We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006-2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation to specific air pollutant. Both cases and controls were selected from a cohort of 1-million beneficiaries of Taiwans National Health Insurance program registered in 2005. Maternal exposures to mean daily air pollutant concentration, derived from 76 fixed air quality monitoring stations within the 12-week period prior to pregnancy and during the 1st and 2nd trimesters, were assessed by the spatial analyst method (i.e., ordinary kriging) with the ArcGIS software. After controlling for potential confounders and other air pollutants, an increase in pre-pregnancy exposure of 1 inter
The persistence of racial disparities in low birth weight (LBW) and preterm birth (PTB) is one of the most widely documented problems in public health. Most studies of these birth outcomes have focused primarily on maternal exposure to individual-level risk factors during the prenatal period. That research has resulted in only a partial explanation for the observed disparities. My research, therefore, had two primary aims: (1) to examine the relationship between adverse birth outcomes and maternal exposure to family and neighborhood disadvantage during childhood; and (2) to determine the behavioral, psychosocial, and health pathways through which these exposures affect birth outcomes and translate into racial disparities. Data for this research came from Waves I and III of the National Longitudinal Study of Adolescent Health (Add Health). The sample consisted of 500 Black and 1,077 White females who gave birth in late adolescence or young adulthood. I used structural equation modeling to test ...
A study of published work was carried out in a search for evidence of a causal role for parental occupational exposure in the origin of structural and functional defects of the central nervous system (CNS) in children. Studies that consider this topic are scarce and mostly refer to broad categories of exposures and effects. Non-occupational studies referring to environmental exposure of humans and studies on experimental animals were also reviewed. The studies on animals provided straightforward evidence about morphological and behavioural abnormalities resulting from some agents used occupationally. The studies on humans yielded a scala of defects that could be ascribed to exposure to high doses of various agents in the environment. Evidence for a causal role of occupational exposure has not been found, but a highly probable influence on the developing CNS is hypothesised for lead, methyl mercury, and ionising radiation. Parental occupational exposure to cadmium, organic solvents, anaesthetics, ...
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John:. I and other community members are still concerned about chemical exposures to all Kipp factory workers, especially women who are or could become pregnant.. As far as VOCs and exposures via vapor intrusion, TCE is of particular concern because it is more toxic than PCE-it is a carcinogen and also causes neurological, immune system, kidney, liver, reproductive, and developmental effects. Many of the effects from fetal exposures may not show up until adulthood. Vapor intrusion screening levels for TCE are much lower than for PCE-see here.** Also, recently government risk assessors concluded that the weight of evidence indicates that TCE and/or its metabolites could cause cardiac defects in fetuses even if maternal exposure durations are short, one-time, and relatively low dose. Below my name, I pasted a summary from an EPA TCE risk assessment document re TCE and heart defects. You can find the IRIS info on TCE toxicity here and here.. We know Kipp used TCE as well as PCE at least into the ...
1 Jamal, A., Agaku, I. T., OConnor, E., King, B. A., Kenemer, J. B., & Neff, L. (2014). Current cigarette smoking among adults-United States, 2005-2013. MMWR Morb Mortal Wkly Rep, 63(47), 1108-1112.. 2 Centers for Disease Control and Prevention. (2016). Current Cigarette Smoking Among Adults in the United States.. 3 Pineles, B. L., Park, E., & Samet, J. M. (2014). Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. American journal of epidemiology, 179(7), 807-823.. 4 Centers for Disease and Control. (2015). Highlights: Impact on Unborn Babies, Infants, Children, and Adolescents.. 5 Cnattingius, S. (2004). The epidemiology of smoking during pregnancy: smoking prevalence, maternal characteristics, and pregnancy outcomes.Nicotine & Tobacco Research, 6(Suppl 2), S125-S140.. 6 Centers for Disease Control and Prevention (2016). How Does Smoking During Pregnancy Harm My Health and My Baby?. 7 American College of Obstetricians and Gynecologists. ...
While increasing evidence suggests that maternal exposure to high levels of ambient air pollutants during pregnancy plays a critical role in producing adverse p...
You said something that, to be honest, really chilled us.You said you would be there for us should we (Kim specifically) ever "require" an abortion. We loved all five of our children well before they were born, throughout our entire pregnancies. Birth didnt change them genetically or inherently, it simply brought them into our full view. You might have extended us an offer to euthanize our toddlers should they become too much of a burden financially, physically or psychologically, and our reaction would have been exactly the same. To one who loves her child from conception onward, there is no distinction. So your offer was lost on us, as we would never deny our own children, whether they sleep safely in our womb or in a crib. You may believe that every woman would submit to an abortion if the circumstances were right, but you would be wrong. And how much more loving and civilized it would have been had you offered to help us with an adoption instead. There are families waiting to adopt every ...
You said something that, to be honest, really chilled us.You said you would be there for us should we (Kim specifically) ever "require" an abortion. We loved all five of our children well before they were born, throughout our entire pregnancies. Birth didnt change them genetically or inherently, it simply brought them into our full view. You might have extended us an offer to euthanize our toddlers should they become too much of a burden financially, physically or psychologically, and our reaction would have been exactly the same. To one who loves her child from conception onward, there is no distinction. So your offer was lost on us, as we would never deny our own children, whether they sleep safely in our womb or in a crib. You may believe that every woman would submit to an abortion if the circumstances were right, but you would be wrong. And how much more loving and civilized it would have been had you offered to help us with an adoption instead. There are families waiting to adopt every ...
Being in the hospital this past week has really forced me to acknowledge the fact that these babies have to come out and not by a wave of a magic wand. This is the part that i have been dreading the most. This entire pregnancy I tried not focusing on the delivery and just on the joy of having my babies in my arms and being a mom. Well now all I think about are these contractions and the big delivery. Honestly its all very daunting to me. I havent committed to a c-section or a vaginal delivery. I get mixed opinions on both and its a lot to consider. With a cesarean I worry about the recovery, the pain of nursing two babies and an incision, not to mention a scar. With vaginally I worry about putting my babies in distress or going through all of the labor and then needing an emergency cesarean anyway. I also worry that if the babies are in position for me to deliver "naturally" and I choose cesarean then I will regret not trying. My doctor is great, he said that if the babies heart rates look ...
Being in the hospital this past week has really forced me to acknowledge the fact that these babies have to come out and not by a wave of a magic wand. This is the part that i have been dreading the most. This entire pregnancy I tried not focusing on the delivery and just on the joy of having my babies in my arms and being a mom. Well now all I think about are these contractions and the big delivery. Honestly its all very daunting to me. I havent committed to a c-section or a vaginal delivery. I get mixed opinions on both and its a lot to consider. With a cesarean I worry about the recovery, the pain of nursing two babies and an incision, not to mention a scar. With vaginally I worry about putting my babies in distress or going through all of the labor and then needing an emergency cesarean anyway. I also worry that if the babies are in position for me to deliver "naturally" and I choose cesarean then I will regret not trying. My doctor is great, he said that if the babies heart rates look ...
RISK AND REALITY: THE IMPLICATIONS OF PRENATAL EXPOSURE TO ALCOHOL AND OTHER DRUGS By Joanne P. Brady, Marc Posner, Cynthia Lang and Michael J. Rosati The Education Development Center, Inc. 1994.
Hey everyone... So, I went to the doc yesterday. They were really nice and she listened to everything from the very beginning. She said that it could still possibly be hemrroids (I dont believe that one), but she said since the prednisone did improve my symptoms that its indictive of inflammation. They really dont want to do a colonoscopy until after I deliver, so they are going to start me on cesena (spelling???) Its a suppository.... Im really nervous, but she said it comes with directions and everything. So my pharmacy ordered it, and it should get here by Friday. She also wants me to ween off the prednisone in the next two weeks, which Im super glad for cuz I wasnt comfortable being on it anyway. She said if the cesena works theyll keep me on that for the entire pregnancy and then do the colonoscopy. If it doesnt work, theyll do a flexiscope, I think she said, in the doctors office. She said it could be Crohns with my family history, but they arent entirely sure. So, they are ...
The other night my honey and I were watching a medical documentary-type show. On it was a young married couple who already had their fair share of hills to climb.. the husband was fighting overseas and the young wife was pregnant. She had been without her husband throughout her entire pregnancy, and their unborn baby…
Sigma-Aldrich offers abstracts and full-text articles by [Ronit Avitsur, Sigal Levy, Rachel Grinshpahet, Naama Goren, Ofer Hirsh, Assaf Zalko].
The goal of the National Birth Defects Prevention Study (NBDPS), an ongoing multi-site case-control study, is to identify environmental and genetic risk factors for birth defects. Information on environmental risk factors is collected through an hour-long maternal interview, and DNA is collected from the infant and both parents for evaluation of genetic risk factors. Clinical data on infants are reviewed by clinical geneticists to ensure they meet the detailed case definitions developed specifically for the study. To standardize the methods of case classification for the study, an algorithm has been developed to guide NBDPS clinical geneticists in this process. ...
CDC works to identify causes of birth defects and opportunities to prevent them. By applying a public health approach incorporating three essential elements-surveillance or disease tracking, research to identify causes, and prevention research and programs-we can rapidly translate scientific findings into appropriate public health interventions.
Hakenewerth, Anne M.; Millikan, Robert C.; Rusyn, Ivan; Herring, Amy H.; Weissler, Mark C.; Funkhouser, William K.; North, Kari E.; Barnholtz-Sloan, Jill S.; & Olshan, Andrew F. (2013). Effects of Polymorphisms in Alcohol Metabolism and Oxidative Stress Genes on Survival from Head and Neck Cancer. Cancer Epidemiology, 37(4), 479-91. PMCID: PMC3725265. Harmon, Quaker E.; Engel, Stephanie M.; Olshan, Andrew F.; Moran, Thomas; Stuebe, Alison M.; Luo, Jingchun; Wu, Michael C.; & Avery, Christy L. (2013). Association of Polymorphisms in Natural Killer Cell-Related Genes with Preterm Birth. American Journal of Epidemiology, 178(8), 1208-18. PMCID: PMC3792727. Lin, Shao; Herdt-Losavio, Michele L.; Chapman, Bonnie R.; Munsie, Jean-Pierre; Olshan, Andrew F.; Druschel, Charlotte M.; & Study, The National Birth Defects Prevention. (2013). Maternal Occupation and the Risk of Major Birth Defects: A Follow-up Analysis from the National Birth Defects Prevention Study. International Journal of Hygiene and ...
In the study, maternal exposure to 10 micro g/ml of BPA in mice enhanced the allergic sensitization and bronchial inflammation and responsiveness in their pups. This dosage mimics the human BPA burden of chronic exposure, including that of pregnant women.. "Previous studies indicated that maternal exposure in mice to environmental BPA enhanced the susceptibility of their pups to allergic asthma," said study co-author Terumi Midoro-Horiuti, MD, PhD. "The goal of this study was to determine the actual threshold of the effects of BPA on allergic sensitization, airway inflammation and hyper-responsiveness.". Female mice received 0, 0.1, 1 and 10 micro g/ml of BPA in their drinking water from one week before pregnancy, during pregnancy and while nursing their pups, in the study conducted at The University of Texas Medical Branch at Galveston.. BPA is a chemical commonly found in polycarbonate plastic bottles and the aluminum lining of food and beverage cans. BPA production started about 40 years ago. ...
Egg defence against bacterial contamination relies on immunoglobulins (IgY) concentrated in the yolk and antimicrobial peptides/proteins predominantly localized in the egg white (EW). Hens contaminated with pathogenic microorganisms export specific IgYs to the egg (adaptative immunity). No evidence of such regulation has been reported for the antimicrobial peptides/proteins (innate immunity) which are preventively secreted by the hen oviduct and are active against a large range of microbes. We investigated whether the egg innate defences can be stimulated by the environmental microbial contamination by comparing the antimicrobial activity of EW of hens raised in three extreme breeding conditions: Germ-free (GF), Specific Pathogen Free (SPF) and Conventional (C) hens. The difference in the immunological status of GF, SPF and C hens was confirmed by the high stimulation of IL-1β, IL-8 and TLR4 genes in the intestine of C and SPF groups. EW from C and SPF groups demonstrated higher inhibitory effect
Objectives This paper presents the results of a pilot study of the job-specific modules developed for use in the study questionnaire of the Northern California Childhood Leukemia Study (i) to estimate the variability in response between people administered the same module and (ii) to estimate the number of modules required per family.. Methods For 63 participants in the pilot study, between-person variability was assessed by comparing reported job tasks among the respondents administered the same job-specific module. Within-respondent variability was assessed by examining changes in the timing and frequency of the job tasks and product use across critical time segments from 12 months before the childs birth to 3 years of age. Parental occupational histories were reviewed to estimate the expected number of job-specific modules required per family.. Results Considerable variability was identified for the tasks performed by the respondents with similar jobs and in the timing of tasks and products ...
Maternal exposure to higher levels of air pollution is associated with lower IQ scores in their children. For those whose mothers were in the highest 10% of exposure had IQ score that were, on average, 2.5 points lower than those whose mothers were in the lowest 10%. However, higher maternal folate levels appear to neurtralize the effect of high pollution exposure on offspring. Read More ...
BACKGROUND: Improving operating room safety and efficiency has received much attention over the past decade. This however has been relatively minimally translated into labor and delivery operating suites. In our academic practice, we have noted that prolonged delays in surgical start times may significantly contribute to sooner anesthetic ware and subsequent maternal exposure to supplemental anesthetics/analgesics. Within the context of improving both safety and efficiency, we sought to evaluate the average time interval between intrathecal anesthetic placement and surgical start. OBJECTIVE: Evaluate the average time between placement of intrathecal anesthetic to surgical incision during routine cesarean section. Secondary objectives included: (1) the frequency of supplemental anesthetic adjuncts utilized, in reference to both anesthetic technique as well as intra-operative times, and (2) the evaluation of neonatal outcomes based upon Apgar scoring at 1 and 5 minutes. METHODS: Retrospective ...
Health, ...Irvine Calif. Young adults whose mothers experienced psychological t...The researchers discovered that this prenatal exposure to stress affec... Our previous research on prenatal stress exposure has shown its effec...Study participants were healthy 25-year-old women and men born to moth...,UCI-led,study,links,prenatal,exposure,to,stress,with,accelerated,cell,aging,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Did you worry the entire pregnancy about the outcome? What helped you calm down and stop the constant worry? It took me until Marisa was about 19 months old and classified as all caught up to even think of getting pregnant again. I was so terrified that if I got pregnant too soon that I wouldnt be able to give her the attention that she needed to catch up. Then of course I had so many uneventful months of trying new doctors and techniques that I had time to get mentally ready for this pregnancy. And then I still wasnt sure if I was ready. My husband didnt even think about bonding with the baby until after my u/s at 19 weeks, and it took me until I got into my second trimester to do much bonding for fear of getting losing this pregnancy.. When I passed the point where the girls were born and I did find a calming factor. Besides in comparison to their pregnancy, this one has been perfect! I feel that having a 36-week preemie was such a joy in comparison to 24 weekers, birth/death experience! ...
Im so sorry for your loss. I know how painful it is to loose baby. Its very good you decided not to give up and look for solutions. I was diagnosed with glomerulonephritis after the birth of my first child. The entire pregnancy I had preeclampsia and hematuria, but not a single gynecologist didnt consider to send me to a nephrologist. When my son was 2 years old Ive got pregnant again. I thought if I could carry my baby once, I can do this again. I was very careful, I tried to nervous less, I quitted my job. I had a diet, nothing spicy and no salt, only healthy food. At the beginning of pregnancy the protein was 0.33 and the pressure was 120/80. Everything seemed to be fine. At 25th week of pregnancy the situation changed completely. The protein was 6-7 and the pressure 230/100. I felt that the child almost didnt move. Doctors told to do an abortion. A cesarean section was urgently made. My second son was born with a weight of 540 grams and had lived for only 2 days. Ive almost lost my ...
I recently gave birth to a beautiful baby girl. My entire pregnancy was so incredible -- I loved every minute of it! I never thought for one minute that my baby could have anything wrong with her. But alas, she was born with a hand deformity that was not diagnosed in utero. I cried non-stop for days. My husband would come home from work and cry with me, hold me while I sobbed, "Why our baby?" While I know that this hand deformity will not stop her from becoming an amazing person, amazing daughter, I know she will struggle because of it. I wish it was my hand, not hers that was deformed. I wish I could take back whatever I did wrong during my pregnancy. I wish so many things ...
During my first pregnancy I developed severe PIH and eclampsia. My husband and I are thinking about getting pregnant again at the end of this year and Im wondering if I should go to a high-risk OB/GYN or continue to see my current OB/GYN. My family is extremely concerned that my current doctor didnt see the signs of my condition much earlier, even though I showed no signs of preclampsia throughout my entire pregnancy until my 32 week. Please advise if I should go to a high-risk doctor and if so, do I ask for a recommendation from my current doctor? Thanks, in advance ...
Hi everyone. I am 8 weeks with my first (hopefully our rainbow) and am really leaning towards going unassisted for my entire pregnancy. I have never had a good experience with western medicine, and at the one OB appointment I have had so far, even though the doc was very kind and natural-birth minded, I still could not shake the feeling of being so very unempowered in his presence. I would go with a midwife but I am concerned about the out of pocket expenses as we are young and our insurance would cover very little. My fiance is, understandably, not so keen on the idea, as he feels we do not have the experience to birth unassisted our first go around. I, however, feel pretty confident with my bodys ability to birth. Does anyone have any stories/advice/encouragement for a FTM (first time mom) considering UC? Thank you all.
The history of advances in the understanding of the toxic effects of lead over the past 20 years is an outstanding example of how knowledge learned from research can impact public health. Measures that have had the greatest impact on reducing exposur
The Exposure Assessment Section (EAS) investigates human exposure to chemical or biological hazards in the environment. We evaluate how exposures affect health and how we can reduce harmful exposures ...
เพิ่ม DIBP ในรายการ Phthalate . ใหม่นี้ แปลกกว่าข้ออื่นที่คุ้นเคยกันคือ เป็นข้อห้ามรายการเก่า (รายการที่ 51) ซึ่งเดิมมีพธาเลท 3 ชนิด ...
Alman, Breanna L.; Coffman, Evan; Siega-Riz, Anna Maria; & Luben, Thomas J., for the National Birth Defects Prevention Study. (2017). Associations between Maternal Water Consumption and Birth Defects in the National Birth Defects Prevention Study (2000-2005). Birth Defects Research, Part A: Clinical and Molecular Teratology, 109(3), 193-202.
NBDPS analyzes effects of Effexor exposure on unborn babies. Contact the Effexor Birth Defect Lawyers at Schmidt & Clark, LLP, for Effexor Lawsuit information.
Maternal smoking during pregnancy is associated with a variety of adverse neonatal outcomes including altered reproductive performance. Herein we provide molecular evidence for a pathway involved in the elimination of the female germline due to prepregnancy and/or lactational exposure to polycyclic aromatic hydrocarbons (PAHs), environmental toxicants found in cigarette smoke. We show that ovaries of offspring born to mice exposed to PAHs contained only a third of the ovarian follicle pool compared with offspring of unexposed female mice. Activation of the cell death pathway in immature follicles of exposed females was mediated by the aryl hydrocarbon receptor (Ahr), as ovarian reserve was fully rescued by maternal cotreatment with the Ahr antagonist, resveratrol, or by inactivation of the Ahr gene. Furthermore, in response to PAHs, Ahr-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death. This pathway appeared to be ...
It is difficult to study the effect of cigarette smoke on humans in a systematic way; therefore, we studied the effect of cigarette smoke exposure on cardiac t...
Data & statistics on Blood Disorders Therapeutics: Blood, and Body Fluids Disorders Pharmacology and Therapeutics, Counts of top 20 reported events (preferred terms) since approval* Top 20 preferred terms Complications of maternal exposure to therapeutic drugs Maternal drugs affecting fetus Hypertriglyceridemia Diarrhea Pyrexia Cesarean section Vomiting Blood lactic acid increased Neonatal disorder Pregnancy Lactic acidosis Anemia Abdominal pain Blood creatine phosphokinase increased Myocardial infarction Asthenia ..., 730100 CLINICAL (ORGANS, DISEASES & CONDITIONS) 730101 Infectious diseases 730102 Immune system and allergy 730103 Blood disorders 730104 Nervous system and disorders 730105 Endocrine organs and diseases (incl. diabetes) 730106 Cardiovascular system and diseases 730107 Inherited diseases (incl. gene therapy) 730108 Cancer and related disorders 730109 Surgical methods and procedures 730110 Respiratory ......
Late-onset neonatal infections: incidences and pathogens in the era of antenatal antibiotics. Didier, Capucine; Streicher, Marie-Pierre; Chognot, Didier; Campagni, Raphaèle; Schnebelen, Albert; Messer, Jean; Donato, Lionel; Langer, Bruno; Meyer, Nicolas; Astruc, Dominique; Kuhn, Pierre // European Journal of Pediatrics;Apr2012, Vol. 171 Issue 4, p681 Widespread use of intrapartum antimicrobial prophylaxis has significantly reduced the incidence of early-onset neonatal infection (EONI); however, little is known about the effects of increased maternal exposure to antibiotics on late-onset neonatal infection (LONI). This study aims to evaluate... ...
Li YF, Gililand FD, Berhane K, McConnell R, Gaudermann WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. Am J Respir Crit Care med 2000; 162 (6):2097-104 ...
Li YF, Gililand FD, Berhane K, McConnell R, Gaudermann WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. Am J Respir Crit Care med 2000; 162 (6):2097-104 ...
Perinatal exposure to low doses of PCB 153 and PCB 126 affects maternal and neonatal immunity in goat kids.: Pregnant does (10 goats/group) were dosed orally ei
PREGNANCY NAUSEA: It seems to come with the territory. More than 80% of women suffer from nausea and vomiting in the first trimester of pregnancy. Thankfully, it goes away for most, but some have to endure it for their entire pregnancy.
Up to 90% of pregnant women experience nausea and vomiting during pregnancy. Symptoms usually start around the 6th week of pregnancy and stop around the 12th week. Some women however, will continue to experience nausea and vomiting throughout their entire pregnancy. Contrary to popular belief, nausea and vomiting can occur at any point during the day, not only in the morning. - Medicine Shoppe
I am sorry for your loss. Protein S def. seems to be very rare. I have never met anyone else with it. Even on the boards here there has not been much response on it. I did not go on to develop hellp in any of my pregnancies, although I had early onset severe pre eclampsia and PIH and mild pre eclampsia. I am now on Heparin while pregnant. I also have homo. MTHFR. I am now 23 wks with this, my third pregnancy. At this time my bps are good-sometimes great. I was diagnosed near the end of my 2nd pregnancy so this is my first pregnancy using heparin the entire pregnancy. I feel like it has made a difference so far ...
Read about a new study conducted by the Norwegian Institute of Public Health has confirmed a link between prenatal exposure to acetaminophen and an increased risk of developing asthma in early childhood.
The level of food consumption was lower in male offspring (IVC=171.7±9; CC=193.1±20) than in female offspring (IVC=100.6±7; CC=123.4±0.4), whereas the water intake was higher in female offspring (IVC=149.8±11; CC=99.2±0) than in male offspring (IVC=302.5±25; CC=249.7±22) at 11 weeks of age when housed in IVCs. The cage temperature was higher in individually ventilated cages than in conventional cages for both male (IVCs=25.9±0.5; CCs=22.95±0.3) and female (IVCs=26.2±0.3; CCs=23.1±0.3) offspring. The respiratory resistance (IVC=68.8±2.8; CC=50.6±3.0) and elastance (IVC=42.0±3.9; CC=32.4±2.0) at 300 µm/kg were higher in the female offspring housed in ventilated cages. The ciliary beat values were lower in both the male (IVCs=13.4±0.2; CC=15±0.4) and female (IVC=13.5±0.4; CC=15.9±0.6) offspring housed in individually ventilated cages than in those housed in conventional cages. The total cell (IVC=117.5±9.7; CC=285.0±22.8), neutrophil (IVC=13.1±4.8; CC=75.6±4.1) and ...
Sigma-Aldrich offers abstracts and full-text articles by [Huai-Cai Zeng, Qing-Zhi He, Yuan-Yuan Li, Cheng-Qiu Wu, Yi-Mou Wu, Shun-Qing Xu].
BELGRADE, Mont., Aug. 1, 2011 /PRNewswire via COMTEX/ -- Bacterin International Holdings, Inc.BONE -3.78% , a leader in the development of revolutionary bone
Fish consumption prior to pregnancy and pregnancy outcomes in the National Birth Defects Prevention Study, 1997-2011 - Volume 22 Issue 2 - Renata H Benjamin, Laura E Mitchell, Mark A Canfield, Adrienne T Hoyt, Dejian Lai, Tunu A Ramadhani, Suzan L Carmichael, Amy P Case, D Kim Waller, the National Birth Defects Prevention Study
As epidemiological studies expand to examine gene-environment interaction effects, it is important to identify factors associated with participation in genetic studies. The National Birth Defects Prevention Study is a multisite case-control study designed to investigate environmental and genetic risk factors for major birth defects. The National Birth Defects Prevention Study includes maternal telephone interviews and mailed buccal cell self-collection kits. Because subjects can participate in the interview, independent of buccal cell collection, detailed analysis of factors associated with participation in buccal cell collection was possible ...
Maternal consumption of alcohol during pregnancy is associated with alterations in fetal development that negatively impact the offspring causing neurochemical and neurobehavioural dysfunction termed fetal alcohol spectrum disorders; the most severe outcome is fetal alcohol syndrome. Changes in maternal and fetal hypothalamic-pituitary-adrenal (HPA) axis activation, induction of cytochrome P450 2E1 (CYP2E1) enzyme activity and alterations in micronutrient status, including folate, following chronic ethanol exposure (CEE) are key contributors to the neuroendocrine and neurobehavioural effects observed in offspring. This study tested the following hypotheses: Maternal consumption of ethanol throughout pregnancy can: alter maternal and fetal HPA axis function and induce CYP2E1 enzyme activity in the third-trimester-equivalent; decrease folate status in the maternal-fetal unit, which can be mitigated by folic acid supplementation; and cause neurobehavioural deficits in offspring at low-moderate dose ...
In this study we examined the relationship between gestational exposure to 53 different EDCs and birth weight in a prospective birth cohort of mother-infant pairs. We found that exposure to phthalates and BPA, PFAS, PCBs, PBDEs or OCPs had null or small associations with birth weight. Other investigators have reported similar small or statistically non-significant associations between birth weight and phthalates [37], PCBs [15], PBDEs [13], and OCPs [25]. Several other studies, however, have found associations between increased exposure to phthalates, PCBs, PBDEs or OCPs whereas we did not. A case-control study by Zhang et al. [24] revealed that low birth weight infants in China tended to have much higher meconium phthalate levels than infants who were normal weight. Additionally, a meta-analysis by Govarts et al. [21] reported that increased exposure to PCBs was associated with decreased birth weight. Lignell et al. [27] found a statistically significant inverse association between PBDE ...
Birth Defect Research for Children (BDRC)provides birth defect information, parent networking, resource referral and news updates on birth defect prevention. BDRC sponsors the National Birth Defect Registry, a project that collects data for birth defect research. ...
Pregnant women with cystitis are prescribed only one of two approved drugs - 500 mg nightly. Medically peer reviewed studies. Around 1 in 5 mothers were prescribed antibiotics during pregnancy, urine cultures are contaminated in pregnancy, including pregnant women because they do decrease good bacteria in the gut microbiome. Once the baby is born, gPs needed to consider that any female of childbearing age could be pregnant antibiotics prescribing antimicrobials. Antibiotics in the can pregnancy of pregnancy use be in only by a doctor, before culture results are available. Amoxicillin during pregnancy is a penicillin antibiotic, share cases and questions with Physicians on Medscape consult.. Just because these fetal attacks happened in the past, medical Daily is for informational purposes and should not be considered medical advice, antibacterial medication use during pregnancy and risk of birth defects: National Birth Defects Prevention Study. Can You Get Pregnant Before - india and has ...
Isolation and Degradation Activity of a TBTCl (Tributyltin Chloride) Resistant Bacteriain Gwangyang Bay - Gwangyang Bay;Pantoea sp. T7;TBTCl-degrading activity;Tributyltin Chloride;
A blog post discussing research suggesting elevated levels of primary and secondary phthalate metabolites are present in cases of autism.
pliances. To tell the truth, that for a long time to sit at a computer is harmful not only to pregnant women, but also quite ordinary people. Where it is more useful to walk in the fresh air. Useful or harmful for the fetal ultrasound that is made pregnant by Every pregnant woman should perform ultrasound of the fetus, at least three times during the entire pregnancy. The old-schooled midwives adhere to the previous view of this question and believe that once again doing ultrasound does not even need anything, since this device also emits radiation, even ultrasound. Modern specialists, however, assure that the ultrasound can not cause any harm. As you can see, opinions polarly diverge, therefore, in order not to risk once again, we will perform only those ultrasounds that are laid. And in order to specifically find out who you will have, boy or girl, go for ultrasound, apparently, should not. Is it possible to conceive pregnant women There is a steady and unconfirmed opinion that if the future ...
Im pregnant but I just feel fat.. I cant believe I said it - not once, not twice but repeatedly throughout my entire pregnancy. I started to feel that way at the beginning of my first trimester and it continued all the way through week 40. It is bad enough that the feeling reflected my own distorted body image, but Im not the only one. Ive heard it from far too many other pregnant women. In fact my pregnant cousin, 27 weeks along and absolutely stunning, recently posted a comment under a belly shot on her Facebook page exclaiming, "I feel gross and funny looking." The thread that followed included countless reassuring comments from friends insisting that she looks beautiful (and, she does) and that the weight gain is all baby.. My cousin and I are part of an increasing trend of women that bring societys cult-of-thinness-mentality into pregnancy, manifesting in an underlying fear of weight gain and (normal and natural) bodily changes. Instead of equating the swelling belly, rounded breasts ...
Alcohol is a teratogen substance that is toxic to the babys developing brain.. Damage can occur in various regions of the brain. The areas that might be affected by alcohol exposure depend on which areas are developing at the time the alcohol is consumed. Since the brain and the cntral nervous system are defeloping throughaut the entire pregnancy, the babys brein is always vulnerable to damage from alcohol exposure. Teresa Kellermann. The brain is the most sensitive organ to alcohol damage (Dr. Edward Riley lecture at San Diego State University, September 25, 2002). Not all damage from alcohol exposure is seeen on brain scans, as lesions are sometimes too small to be detected with current technology, yet large enough to cause significant disabilities.. ==,Top. ...
My entire pregnancy with Laura was fraught with anxiety due to our two previous losses. While I felt slightly less anxious with each positive milestone that we passed, I never was really able to settle down. As my pregnancy drew closer to full-term, I began feeling increasing anxiety about labor and delivery. I was worried that my labor would go so fast that we wouldnt make it to the hospital in time, and that wed have an unplanned home birth or car birth (this fear stemmed from the fact that Peters birth as very nearly an unplanned car birth). I was worried that I wouldnt be able to handle he the pain of labor, despite having had five unmedicated births. I was worried that something would go wrong during labor -- hemorrhaging, or placental abruption, or a host of other maladies -- and we would lose the baby. And so on ...
My entire pregnancy with Laura was fraught with anxiety due to our two previous losses. While I felt slightly less anxious with each positive milestone that we passed, I never was really able to settle down. As my pregnancy drew closer to full-term, I began feeling increasing anxiety about labor and delivery. I was worried that my labor would go so fast that we wouldnt make it to the hospital in time, and that wed have an unplanned home birth or car birth (this fear stemmed from the fact that Peters birth as very nearly an unplanned car birth). I was worried that I wouldnt be able to handle he the pain of labor, despite having had five unmedicated births. I was worried that something would go wrong during labor -- hemorrhaging, or placental abruption, or a host of other maladies -- and we would lose the baby. And so on ...
When I first discovered it I used to be pregnant, I strongly craved hen and peanut butter. For a few women, it lasts throughout the entire pregnancy. I was simply very, very lucky that I did not turn into pregnant in those 8 years, but the truth that I could have, combined with the debilitating pain I lived with, made the insurance coverage firms actions not only intrusive, but inhumane. The bumps on the areolas planned parenthood fort collins look more prominent. 21, 2013. Visualization planned parenthood fort collins helps you preserve a more constructive and accepting perspective of your journey in the direction of plannedd pregnant. Nonetheless, if ginger tea for nausea during pregnancy first time you had parenthhood C-section, then the second time the labor phase wont be decreased. This more expensive test, which also appears to be like for hCG, can produce a result inside nine to 12 planed after conception ...
This study was conducted to evaluate the use of metabolomics for improving our ability to draw correlations between early life exposures and reproductive and/or developmental outcomes. Pregnant CD rats were exposed daily during gestation (gd 14-21) to vehicle or to butyl benzyl phthalate (BBP) at a level (750 mg/kg) known to induce effects in the offspring and at a level (25 mg/kg) not expected to induce effects.
Phthalates is used in various plastics and are sometimes used in supplements because of their ability to release ingredients slowly into the body Studies shown there could be a link between Phthalate exposure and potential birth defects, infertility, stunted growth, low IQs and the developing male reproductive system.
Babies born to mothers who suffered from depression during pregnancy are more likely to experience significant delays in their development than their peers, suggests a new study.
Coating the mouth with BPA-containing food, like soup, does not lead to higher than expected levels of BPA in blood, a new study in Toxicology and Applied Pharmacology shows. The study authors conclude that oral exposure does not create a risk for high exposures of BPA, also known as bisphenol A.
Ravgen focuses on offering the best prenatal genetic testing available. For more information or questions contact us at (410) 715-2111.
Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl phthalate (DBP; from gestational day (GD) 14.5 to postnatal day (PND) 6) or diethylstilbestrol (DES; from GD14.5 to GD16.5) during a short gestational/lactational window, and male offspring subsequently analysed for various postnatal testicular parameters. All offspring remained in good health throughout the study. Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of ...
Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis in offspring aged 5 years. From 552 pregnant women in the Odense Child Cohort, we quantified urinary concentrations of 12 phthalate metabolites in third trimester. We assessed asthma, rhinitis and eczema in their offspring at age 5 years with a questionnaire based on the International Study of Asthma and Allergies in Childhood (ISAAC), and conducted logistic regression adjusting for relevant confounders. 7.4% of the children had asthma, 11.7% eczema and 9.2% rhinitis. Phthalate exposure was low compared to previous cohorts. No significant associations between prenatal phthalate exposure and asthma were found. Odds ratios (ORs) of child rhinitis with
Background: Multiple studies have suggested a relationship between adult exposures to environmental organochlorines and fecundability. There is a paucity of data, however, regarding fetal exposure to organochlorines via the mothers blood and fecundability of adult female offspring. Methods: Data from a two-generation cohort of maternal fisheaters was investigated to assess female offspring fecundability. Serum concentrations of polychlorinated biphenyls (PCBs) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (DDE) in Michigan female anglers were serially measured between 1973 and 1991 and used to estimate in utero exposure in their female offspring using two different methods. The angler cohort included 391 women of whom 259 provided offspring information. Of 213 daughters aged 20-50, 151 participated (71 %) and provided information for time intervals of unprotected intercourse (TUI). The daughters reported 308 TUIs (repeated observations), of which 288 ended in pregnancy. We estimated the ...
This month we celebrate National Birth Defects Prevention Month. The National Birth Defects Prevention Network (NBDPN) has set the 2015 theme as "Making Healthy Choices to Prevent Birth Defects-Make a PACT for Prevention." The anagram within the theme, "PACT," stands for the following: (P)lan ahead (A)void harmful substances (C)hoose a healthy lifestyle (T)alk to your…. Read More ...
Cannabis consumption in pregnancy might be associated with restrictions in growth of the fetus, miscarriage, and cognitive deficits. The American Congress of Obstetricians and Gynecologists recommended that cannabis use be stopped before and during pregnancy, Cannabis is the most commonly used illicit substance among pregnant women. Although it is difficult to draw firm conclusions, there is some evidence that prenatal exposure to marijuana may be associated with deficits in language, attention, cognitive performance, and delinquent behaviors. THC exposure in rats during the prenatal developmental phase may cause epigenetic changes in gene expression, but there is limited knowledge about the risk for psychiatric disorders because of ethical barriers to studying the developing human brain. While animal studies cannot take into account factors that could influence the effects of cannabis on human maternal exposure, such as environmental and social factors, a 2011 review of rodent studies by ...
The Prevention Agent Pregnancy Exposure Registry, also known as EMBRACE (Evaluation of Maternal and Baby Outcome Registry After Chemoprophylactic Exposure) is a prospective observational cohort study of maternal exposures to investigational HIV prevention agents. Approximately 550 pregnant participants and 400 live infants will be offered enrollment. The study population will consist of current or recent female participants identified as becoming pregnant during microbicide or PrEP trials, or who have had planned exposures in pregnancy safety studies. This study will also include infants resulting from those pregnancies. This protocol will monitor for adverse pregnancy and delivery outcomes, monitor the prevalence of major malformations, evaluate growth parameters of infants during the first year of life, and evaluate the prevalence and persistence of HIV drug resistance mutations in a cohort of infants who were either exposed to active study agents or not exposed to active study agents while in ...