TY - JOUR. T1 - Feasibility of membrane inlet mass spectrometry for on-site screening of volatile monoterpenes and monoterpene alcohols in forest soil atmosphere. AU - Ketola, Raimo A.. AU - Kiuru, Jari. AU - Kotiaho, Tapio. AU - Kitunen, Veikko. AU - Smolander, Aino. PY - 2011. Y1 - 2011. N2 - Volatile monoterpenes and monoterpene alcohols exist in the forest soil atmosphere and they may play an important role in controlling microbial processes related to C and N cycling in boreal forest soils. Therefore, information is needed about their actual concentrations in the soil atmosphere. Here, we developed and applied membrane inlet mass spectrometry (MIMS) with a simple sampling probe for an on-site determination of the most common monoterpenes and monoterpene alcohols in the forest soil atmosphere. The MIMS method was also compared with a chamber method for collection samples into sorbent tubes and an off-line static headspace GC-FID analysis. The sampling principles of the methods are different: ...
Persistence Market Research has studied the overall performance of the global liquid chromatography-mass spectroscopy market and have observed that the market is likely to show significant growth owing to a rising demand for liquid chromatography-mass spectroscopy systems across various applications.
The standard atomic weight (or atomic weight) scale has traditionally been a relative value, that is without a unit, with the first relative atomic mass basis suggested by John Dalton in 1803 as 1H.[8] Despite the initial mass of 1H being used as the natural unit for relative atomic mass, it was suggested by Wilhelm Ostwald that relative atomic mass would be best expressed in terms of units of 1/16 mass of oxygen (1903). This evaluation was made prior to the discovery of the existence of elemental isotopes, which occurred in 1912.[8]. The discovery of isotopic oxygen in 1929 led to a divergence in relative atomic mass representation, with isotopically weighted oxygen (i.e., naturally occurring oxygen relative atomic mass) given a value of exactly 16 atomic mass units (amu) in chemistry, while pure 16O (oxygen-16) was given the mass value of exactly 16 amu in physics. The divergence of these values could result in errors in computations, and was unwieldy. The chemistry amu, based on the relative ...
HR Institute of Forensic Science Research & Training (REGD.) - Service Provider of Training On Mass Spectrometry based in Delhi, India
TY - JOUR. T1 - Determination of active hydrogen in organic compounds by electron‐impact mass spectrometry. AU - Dinya, Z.. AU - Lipták, Miklós. AU - Szabó, Pál. AU - Sztaricskai, F.. AU - Vékey, K.. PY - 1992. Y1 - 1992. N2 - We report here detailed studies of Bose et al.s (J. Org. Chem. 47, 4008 (1982)) simple method for obtaining electron‐impact (EI) mass spectra from non‐volatile and/or thermolabile organic compounds by using ammonium salts. Good quality mass spectra can be obtained by mixing the analyte with different ammonium salts (mainly with NH4Cl) in a given ratio, the mixture being introduced through a conventonal direct probe. A wide variety of ammonium salts has been used to study the effect of the anion and to determine the optimum analyte:NH4X ratio and the other experimental parameters (i.e., electron energy, source temperature etc). A very simple and cheap means of determination of active hydrogen in hydroxyl, carboxyl, sulfhydryl, amino and amido etc groups by EI ...
A comprehensive Collision Cross Section (CCS) library was obtained via Travelling Wave Ion Guide mobility measurements through direct infusion (DI). The library consists of CCS and Mass Spectral (MS) data in negative and positive ElectroSpray Ionisation (ESI) mode for 463 and 479 endogenous metabolites, respectively. For both ionisation modes combined, TWCCSN2 data were obtained for 542 non-redundant metabolites. These data were acquired on two different ion mobility enabled orthogonal acceleration QToF MS systems in two different laboratories, with the majority of the resulting TWCCSN2 values (from detected compounds) found to be within 1% of one another. Validation of these results against two independent, external TWCCSN2 data sources and predicted TWCCSN2 values indicated to be within 1-2% of these other values. The same metabolites were then analysed using a rapid reversed-phase ultra (high) performance liquid chromatographic (U(H)PLC) separation combined with IM and MS (IM-MS) thus ...
Glycans are compounds that consist of a large number of monosaccharides. Glycans can be homopolymers or heteropolymers of monosaccharide residues and can either be linear or branched. Glycans are found on the exterior surface of cells and can be found attached to proteins as in glycoproteins and proteoglycans. In glycan analysis which seeks to explore the structure and functions of various glycans, high-resolution mass spectrometry (MS) and high-performance liquid chromatography (HPLC) are commonly used.. Mass spectrometry (MS) offers high sensitivity and addresses the most frequent biological issues hence it is a valuable tool for the structural characterization of carbohydrates. Oligosaccharide structures can be explained through mass spectrometry and chromatographic separation derivatization. Some of the techniques used for mass spectrometry are Gas Chromatography coupled to Mass Spectrometry (GC/MS), Liquid Chromatography with Mass Spectrometry (LC/MS), Ion mobility-mass spectrometry (IM-MS) ...
View detailed Table of Content here - https://www.marketsandmarkets.com/Market-Reports/mass-spectrometry-market-437.html. The increasing spending on pharmaceutical R&D across the globe, government regulations on drug safety, growing focus on the quality of food products, and technological advancements in mass spectrometers are the key drivers of the mass spectrometry market. Government initiatives for pollution control and environmental testing and an increase in crude and shale gas production are also supporting the growth of this market.. Hybrid mass spectrometers are estimated to account for the largest share of the mass spectrometry platform market in 2019. The mass spectrometry market is segmented on the platform into hybrid mass spectrometry, single mass spectrometry, and other platforms. The hybrid mass spectrometry segment is further divided into triple quadrupole, quadrupole TOF, and Fourier transform mass spectrometry devices, while the single mass spectrometry segment includes single ...
In physics and chemistry, the atomic mass constant, mu, is one twelfth of the mass of an unbound atom of carbon-12 at rest and in its ground state. It serves to define the atomic mass unit and is, by definition, equal to 1 u. The CODATA recommended value is 6973166053904000000♠1.660539040(20)×10−27 kg. In practice, the atomic mass constant is determined as the ratio of the electron rest mass me to the electron relative atomic mass Ar(e) (that is, the mass of the electron on a scale where 12C = 12). The relative atomic mass of the electron can be measured in cyclotron experiments, while the rest mass of the electron can be derived from other physical constants. m u = m e A r ( e ) = 2 R ∞ h A r ( e ) c α 2 {\displaystyle m_{\rm {u}}={\frac {m_{\rm {e}}}{A_{\rm {r}}({\rm {e}})}}={\frac {2R_{\infty }h}{A_{\rm {r}}({\rm {e}})c\alpha ^{2}}}} The current uncertainty in the value of the atomic mass constant - one part in 20 million - is almost entirely due to the uncertainty in the value of the ...
The Year of Education is a joint initiative between separationsNOW and Chromedia. Read more about Chromedia and subscribe Free, Live and Interactive Educational Webinar Sports Drug Testing Chromatography and Mass Spectrometry-Based Approaches This webinar has been broadcast and is now available on demand. Professor Mario Thevis discusses the...
The Year of Education is a joint initiative between separationsNOW and Chromedia. Read more about Chromedia and subscribe Free, Live and Interactive Educational Webinar Sports Drug Testing Chromatography and Mass Spectrometry-Based Approaches This webinar has been broadcast and is now available on demand. Professor Mario Thevis discusses the...
Article Identification of compounds in water by high resolution mass spectrometry. A chemical manufacturer for the rubber and plastics industries used over 100 chemicals for syntheses. For at least 30 years, some fractions of these chemicals, synthes...
Biotech Support Group to exhibit at the 67th ASMS Conference on Mass Spectrometry & Allied Topics. Biotech Support Group will exhibit at the annual ASMS Conference, June 2-6, 2019 in Atlanta, GA. The American Society for Mass Spectrometry (ASMS) was formed in 1969 to promote and disseminate knowledge of mass spectrometry and allied topics. - PR12768157
The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i.e., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products
This volume explores state-of-the-art mass spectrometric techniques. It focuses on liquid chromatography/mass spectrometry/mass spectrometry and time-of-flight/mass spectrometry to determine emerging contaminants, such as pharmaceuticals, hormones, pesticides, surfactants and unknown natural products.
Touch spray mass spectrometry using medical swabs is an ambient ionization technique (ionization of unprocessed sample in the open air) that has potential intraoperative application in quickly ide ...
ISMAS organizes Workshops on Mass Spectrometry at Research Institutes and Universities in different parts of India. These Workshops are aimed at introducing the subject of Mass Spectrometry to novices, updating the Mass Spectrometrists with the latest developments in the field, exposing the participants to innumerable applications of Mass Spectrometry and providing a common forum for discussing the day-to-day problems when working with a Mass Spectrometer. The programme of these Workshops consists of Tutorials, Panel Discussions, Research Scholar Presentations, Poster Presentations and Invited Lectures. The lectures include fundamentals of Mass Spectrometry, qualitative and quantitative aspects and data interpretation, maintenance of Mass Spectrometers, selection of a mass spectrometer, applications in various branches of science as well as recent advances in Mass Spectrometry. The lectures are supplemented by (i) Open-forum discussions on the experiences gained by the Resource Persons (faculty) ...
The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role.. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives. All papers should describe new mass spectrometry science. Reports of applications that utilize standard mass spectrometry approaches should be sent to application journals.. 2015 Impact Factor: 3.031. ...
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Browse more than 73 market data tables with 17 figures spread through 199 pages and in-depth TOC on "Mass Spectrometry Market".. http://www.marketsandmarkets.com/Market-Reports/mass-spectrometry-market-437.html. Early buyers will receive 10% customization on this report.. This report covers the definition, description, and forecast of the mass spectrometry market in terms of technologies and applications. Based on technologies, the mass spectrometry market comprises Tandem LC/MS, LC/MS-Time of Flight, MALDI-TOF, Single Quadrupole, Fourier Transform MS, Gas Chromatography/MS, and others. The applications market is categorized into pharmaceuticals, biotechnology, industrial chemistry, environmental testing, food and beverage testing, and others.. Over the years, the demand for mass spectrometry has increased significantly owing to the increasing use of mass spectrometry technologies to address the growing concerns in food safety and the increasing number of government funds and spending on ...
Our patented, chip-based miniaturised mass spectrometry technology enables analytical detection at the point-of-need in laboratories or bioprocessing facilities
Pyrolysis and mass spectrometry studies of meteoritic organic matter Mass Spectrometry Reviews , 2012, 31 , 560-569 M.A. Sephton Abstract Meteorites are fragments of extraterrestrial materials that fall to the Earths surface. The carbon-rich meteorites are derived from ancient asteroids that have remained relatively unprocessed since the...
The combination of stable isotope labelling with direct infusion ion mobility mass spectrometry (IM-MS) enabled qualitative and quantitative monitoring of biocatalytic reactions with reduced analysis times, enhanced sensitivity and μL-level assay volumes. The new approach was demonstrated by applying to both lipase and monooxygenase enzymes, including multi-substrate screening ...
TY - JOUR. T1 - Monitoring organic compounds in aqueous solution by rotating ball inlet mass spectrometry with continuous wave infrared laser desorption. AU - Schmidt, E.N.. AU - Ørsnes, H.. AU - Graf, T.. AU - Christensen, T.. AU - Degn, H.. PY - 2001. Y1 - 2001. U2 - 10.1016/S0925-4005(01)00649-9. DO - 10.1016/S0925-4005(01)00649-9. M3 - Journal article. VL - 76. SP - 411. EP - 418. JO - Sensors and Actuators B: Chemical. JF - Sensors and Actuators B: Chemical. SN - 0925-4005. ER - ...
Manufacturer of Liquid Chromatography Mass Spectrometry - LCMS QQQ 6460 Mass Spectrometer, CAH Mass Solution offered by Trivitron Healthcare Pvt. Ltd., Chennai, Tamil Nadu.
Laser isotope mass spectrometry is the next-generation technology for measuring environmental isotopes, and the Groundwater Education Investment Fund (GEIF) has invested in a suite of instruments to enable state-of-art research capabilities for groundwater research in Australia.. The ability to measure oxygen and hydrogen isotopes in liquid water and water vapour is of great value in both field and laboratory settings.. In the field, water vapour analyses help quantify the water budget as they can constrain water loss incurred due to evapotranspiration from vegetation. In the laboratory, the ancient pore water can be measured in aquitard material and can characterise water movement in aquitards through the vapour equilibrium technique.. Laser isotope mass spectrometry can also be used for isotope analysis of the carbon contained in dissolved organic and inorganic carbon and gaseous methane.. One of the main benefits of a method for the routine measurement of liquid water samples by isotope mass ...
Learn about Agilent׷ liquid chromatography/mass spectrometry (LC/MS). Agilent LC/MS enables a wide array of applications by combining sample preparation, liquid chromatography (LC), mass spectrometry (MS), and dedicated software tools like compound databases and libraries.
Background In recent years, several mass spectrometry-based omics technologies emerged to investigate qualitative and quantitative changes within thousands of biologically active components such as proteins, lipids and metabolites. The research enabled through these methods potentially contributes to the diagnosis and pathophysiology of human diseases as well as to the clarification of structures and interactions between biomolecules. Simultaneously, technological advances in the field of mass spectrometry leading to an ever increasing amount of data, demand high standards in efficiency, accuracy and reproducibility of potential analysis software. Results This article presents the current state and ongoing developments in OpenMS, a versatile open-source framework aimed at enabling reproducible analyses of high-throughput mass spectrometry data. It provides implementations of frequently occurring processing operations on MS data through a clean application programming interface in C++ and Python. ...
Been many years since I took general and org chem and am currently reading general chem textbook as refresher. Came across defintion of amu (atomic mass unit). Text says that the mass of the carbon-12 atom is defined to be exactly 12 amu. However, a couple of pages over, I read that the mass of the proton is about 1.007 amu, and the mass of the neutron is about 1.009 amu. Add up the masses of 6 protons and 6 neutrons for the carbon-12 atom, and you come up with more than 12 amu. I cant resolve this apparent discrepancy. Ive consulted other texts, etc. Does some type of relativistic effect bear on this situation? In other words, does, for example, an isolated proton have a mass of 1.007 amu, but then when part of an atom have a slightly different mass because of some relativistic effect? HELP ...
Characterisation of stereoisomeric α-methylene-γ-lactone furanosidic derivatives by direct chemical ionisation mass spectrometry and liquid secondary ion mass sepctrometry with tandem mass spectrometry ...
Abstract : Butylatedhydroxytoluene (BHT) and 4-methoxyphenol (4-MP) are phenol derivatives that are generally knownfor their antioxidant properties and depigmenting activities. The aim of this study was to evaluate the impact ofbiofield energy treatment on the isotopic abundance in BHT and 4-MP using gas chromatography-mass spectrometry(GC-MS). BHT and 4-MP samples were divided into two parts: control and treated. The control group remaineduntreated while the treated group was subjected to Mr. Trivedis biofield treatment. Control and treated sampleswere characterized using GC-MS. The GC-MS data revealed that the isotopic abundance ratio of 13C/12C or 2H/1H(PM+1)/PM and 18O/16O (PM+2)/PM increased significantly in treated BHT and 4-MP (where PM- primary molecule,PM+1- isotopic molecule either for 13C or 2H and PM+2 is the isotopic molecule for 18O). The isotopic abundance ratioof (PM+1)/PM in the treated BHT and 4-MP was increased up to 181.27% and 380.73% respectively as comparedto their ...
The characterization of protein stability changes and protein-ligand interactions on the proteomic scale is important for understanding the biology of cellular processes. The identification and quantification of protein-ligand binding affinities is critical for disease state analyses and drug discovery. A mass spectrometry-based technique, Stability of Proteins from Rates of Oxidation (SPROX), has been established for the thermodynamic analysis of protein stability and protein-ligand interactions. In the first part of this dissertation, a previously published iTRAQ-SPROX protocol is improved by incorporating a filter assisted sample preparation (FASP) protocol to significantly reduce sample loss during the experiment. Also, in order to eliminate methionine as a potential contaminant that can cause signal suppression during LC-MS/MS analysis, TCEP•HCl is used to quench the H2O2 oxidation instead of methionine. This avoids the potential reaction between the free methionine and the iTRAQ ...
Given the wide diversity in applications of biological mass spectrometry, custom data analyses are often needed to fully interpret the results of an experiment. Such bioinformatics scripts necessarily include similar basic functionality to read mass spectral data from standard file formats, process it, and visualize it. Rather than having to reimplement this functionality, to facilitate this task, spectrum_utils is a Python package for mass spectrometry data processing and visualization. Its high-level functionality enables developers to quickly prototype ideas for computational mass spectrometry projects in only a few lines of code. Notably, the data processing functionality is highly optimized for computational efficiency to be able to deal with the large volumes of data that are generated during mass spectrometry experiments. The visualization functionality makes it possible to easily produce publication-quality figures as well as interactive spectrum plots for inclusion on web pages. spectrum_utils
ReportsnReports.com adds "Mass Spectrometry Market - by Technology (Tandem LC - MS/ Quadrupole/ ICP - MS/ Gas Chromatography - MS/ TOF - MS/ MALDI -TOF/ Fourier Transform - MS) & by Application (Pharmaceutical/ Biotechnology/ Environment/ Food & Beverages) - Global Trends & Forecast to 2018" report to its research database.. Over the years, the mass spectrometry market-comprising of instruments, consumables, and services-has witnessed various technological advancements. These advancements have led to a growth in the number of mass spectrometry applications. Some of the applications using mass spectrometry are drug discovery and development, metabolomics, biomarkers, and diagnostics. However, the high cost of instruments and the need for skilled professionals to operate these highly sophisticated systems are factors that are hindering the market.. The MALDI-TOF segment is one of the fastest-growing segments in the mass spectrometry market, since MALDI-based technologies are expected to find ...
Abstract : 2-Aminopyridine (2-AP) and 2,6-diaminopyridine (2,6-DAP) are two derivatives of aminopyridines that act as animportant organic intermediates, mostly used in medicines, dyes and organic sensors. The aim of the study was to evaluate theimpact of biofield energy treatment on isotopic abundance ratios of 2H/1H, 13C/12C, or 15N/14N, in aminopyridine derivativesusing gas chromatography-mass spectrometry (GC-MS). The 2-AP and 2,6-DAP samples were divided into two parts: controland treated. The control sample remained as untreated, while the treated sample was further divided into four groups as T1, T2,T3, and T4. The treated group was subjected to Mr. Trivedis biofield energy treatment. The GC-MS spectra of 2-AP and 2,6-DAP showed five and six m/z peaks respectively due to the molecular ion peak and fragmented peaks of aminopyridinederivatives. The isotopic abundance ratio of 2H/1H, 13C/12C, or 15N/14N were calculated for both the derivatives and significantalteration was found in the ...
one_half]. Mass spectrometry is an analytical technique vastly used in chemistry, biotechnology, food and safety monitoring, pharmaceutics, genomics, proteomics, and many others. Its academic and economic importance in the UK is thoroughly documented by the British Mass Spectrometry Society (www.bmss.org.uk). The global market amounts to £ 2.5 billion per year. Small mass spectrometers are available, however all in the low range of mass resolution ∆m/m∈10-3-10-4. The mass resolution of the Geonium Chip is given by the cyclotron resonance ∆ωp/ωp, which we aim at 10-7 or above, thus orders of magnitude better than other small mass spectrometers.. The Geonium Chip technology will deliver a cutting-edge mass spectrometry technology at a much lower cost and size than conventional high-end FT-ICR mass spectrometers, which require a superconducting solenoid. The key factor is the achievement of a homogeneous magnetic field at the position of the trapped ions. This can be done with a local ...
Detail záznamu - Tandem mass spectrometry identification and LC-MS quantification of intact cytokinin nucleotides in K-562 human leukemia cells - Detail záznamu - Knihovna Akademie věd České republiky
Mass spectrometry is a multidisciplinary field that has emerged as an indispensable analytical method due to its high sensitivity, universality and specificity. The technique plays vital role in several scientific areas such as chemistry, physics, nuclear technology, biology, material science, forensic science, archaeology, etc. The list of applications continues to grow day by day. In order to promote the activities of Mass spectrometry in India, ISMAS was formed in 1978 during a meeting of mass spectrometrists at Bhabha Atomic Research Centre. The Life-members include mass spectrometrists from research institutes, universities and industry from India as well as abroad. For nearly last four decades, ISMAS has been playing a key role in popularizing mass spectrometry in India by organizing international/national symposia, workshops, theme based meetings on mass spectrometry, recognizing achievements in mass spectrometry through ISMAS awards program etc. A recent addition to the activities of ...
In the article below, Jie Ding, associate director of development and validation at the PPD® Laboratories GMP lab, discusses liquid chromatography-mass spectrometry in drug discovery and development.. In a drug stability program, high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection remains the most common and cost-effective methodology. Even so, UV detection has its own limitations, including poor sensitivity for non-UV absorbing compounds and lack of specificity. These shortcomings in turn have motivated scientists to pursue other alternatives. Mass spectrometry detection is such a candidate. Mass spectrometry (MS) is a detection method that measures the mass-to-charge ratio (m/z) of a compound. Compared to UV detection, MS offers higher sensitivity, better detection limits, and the ability to provide additional molecular weight information-making it an "information rich" detection method.. Over the last two decades, MS has become an important analytical tool to ...
Laboratory professionals who need a primer on the inner workings of liquid chromatography mass spectrometry (LC-MS/MS) should sign up for AACCs new certificate program,
Mass Spectrometry Blog. A Web log of mass spectrometry Web sites, discussion groups, mailing lists and other links and items of interest to the mass spectrometry community.. ...
How does a mass spectrometer work? Gas chromatography and mass spectrometry mass spectrum, by mass, which are you, mas s, forensics on line, mass spectrometry, mass spectrometry and compound structure, qualitative and quantitative information by m.s., organic compounds and mass spectrometry, mass spectrometry and sensitivity, m.s. and specificity, mass spectrometry and molecular weight, isotopic abundance and mass spectrometry, mass spectrometry MS, J.J. Thomson and mass spectrometry, Tate and m.s., structure of chemical compound and m.s., molecular mass and mass spectrometry, m.s. and g.c., gc-ms, drugs and gc-ms, pesticides and gc-ms, clinical analysis and gc-ms, doping control and gc-ms, mass to charge ratio, m/z, mass analyzer, electron-impact mass spectrum,
A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.
This course will discuss details of the statistical experimental design of quantitative mass spectrometry-based proteomic experiments, and the analysis of the acquired data with multiple data processing tools in MSstats. The topics include normalization, principles of statistical inference, summarization of protein abundances from multiple spectral features, derivation of confidence intervals for fold changes, testing proteins for differential abundance, and multivariate analysis for discovery of biomarker. The participants will perform hands-on analyses of the example datasets with open-source software R, MSstats, and other packages.. ...
Kistemaker, P. G, Boerboom, A. J. H, & Meuzelaar, H. L. C. (1975). Laser Pyrolysis Mass Spectrometry: Some Aspects and Applications to Technical Polymers. Dyn. Mass Spectrom., 4, 139-152 ...
Here we describe a strategy for obtaining very high mass accuracy with an LTQ Orbitrap hybrid mass spectrometer. By separately injecting a background ion of known composition into the C-trap, we compensate for drift in the electric field over time. The success of this strategy shows that the mass scale of the orbitrap, that is the proportionality of the frequency and square root of the m/z, is extremely linear, at least to better than 1 part per million. We find that the remaining mass error depends mainly on the signal intensity of the peptide peaks. For any peaks that are not close to the detection limits, we obtained a mass accuracy close to 1 ppm. Even for weak peaks the mass accuracy is still within a few ppm. To further increase the mass accuracy, we averaged mass measurements over the LC peak weighted by signal intensity. In this way, several mass measurements contribute to the final determination, and the mass determination is not based on a signal close to the detection limit as is ...
Borst, J, Van der Snee-Enkelaar, A. C, & Meuzelaar, H. L. C. (1978). Typing of Neisseria gonorrhoeae by Pyrolysis Mass spectrometry. Antonie van Leeuwenhoek, 44 ...
A. Atomic Mass. The average atomic mass is the number at the bottom of each square Found by averaging the natural abundances of its isotopes Atomic mass = # p + + n 0. Mass #. Atomic #. B. Isotopes. Atoms of the same element with different mass numbers. Nuclear symbol:. Slideshow 118389 by Gideon
78069 avhandlingar från svenska högskolor och universitet. Avhandling: Advancing bioinformatics methods for in-depth proteome analysis based on high-resolution mass spectrometry.
Spickett, C.M. and Silajdzic, E. and Mouls, L. and Thomson, K. and Pitt, A.R. (2009) Protein oxidative modifications: new mass spectrometry approaches to detection in biological samples. Free Radical Research, 43 (s1). p. 43. ISSN 1071-5762 Full text not available in this repository.Request a copy from the Strathclyde author ...
Genedata, a leading provider of advanced software solutions for drug discovery and life science research, and LECO, a global leader in analytical instrumentation and mass spectrometers, have announced their collaboration, which brings to market Genedata Expressionist® MSX software compatibility with LECO High Resolution TOFMS (HRT) instrumentation.
MODEL RELEASED. Proteomics and mass spectrometry analysis. Researcher using a mass spectrometer to analyse proteins. This is part of a proteomics and mass spectrometry service provided both to researchers at the University of Dundee, Scotland, and to academic and industrial clients worldwide. The equipment being used here includes a nanoflow liquid chromatography system (in front of researcher), and a quadrupole time-of-flight (Q-TOF) mass spectrometer (right). Photographed in 2016, in Dundee, Scotland. - Stock Image C035/5167
The technique of mass spectrometry is a valuable tool in the field of proteomics. It can be used to identify proteins through variations of mass spectrometry techniques. The most common first approach to proteomics is a bottom-up approach in which the protein is digested by a protease, such a trypsin, and the peptides are then analyzed by peptide mass fingerprinting, collision-induced dissociation, tandem MS, and electron capture dissociation. Once the peptides masses have been determined the mass list can be sent to a database, such as MASCOT, where the list is compared to the masses of all known peptides. If enough peptides match that of a known protein you can identify your protein. If the masses of your peptides do not match a known protein you can sequence your peptide by de novo sequencing using MS/MS methods; where you isolate your peptide and break it along the peptide bond backbone forming y and b ions from which you can determine the sequence. The advantages of the bottom-up approach ...
This text aims to allow new students and professionals to navigate the complex field of mass spectrometry through a comprehensive listing of terms in glossary format. Descriptions are of intermediate complexity, useful for immediate application and understanding. The guide contains hundreds of literature references, which are major points of entry into the primary and secondary literature. Sources for the terms and topics included here include professional organizations relating to mass spectrometry (American Society for Mass Spectrometry, American Vacuum Society, American Society for Testing and Materials, Committee E-14 and the International Union of Pure and Applied Chemistry), scientific meetings and the indices and glossaries of both beginning and advanced books on mass spectrometry ...
Increasing adoption rate of liquid chromatography mass spectrometry in clinical research is a trend in global mass spectrometry market. The liquid chromatography mass spectrometry provides better analytical results compared to conventional high pressure liquid chromatography and immunoassays.
International Summit on Current Trends in Mass Spectrometry will schedule and coordinate all meetings with our Editorial Board Members and other experts in the Mass Spectrometry field across the world. The scientific program paves a way to gather visionaries through the research talks and presentations and put forward many thought provoking strategies in Mass Spectrometry. The scientific program and workshops will focus on current advances in the research and use of Mass Spectrometry with particular focus on its role in research and analytical techniques. The Scientific Meetings will be an evidence of success stories in Mass Spectrometry and developments of existing approaches in Analytical Techniques related to Mass Spectrometry ...
Julia Laskin and Alexander Laskin at Pacific Northwest National Laboratory and Sergey Nizkorodov at University of California, Irvine wrote a comprehensive review of new mass spectrometry techniques for analyzing miniscule, rapidly evolving atmospheric particles that affect the climate and human health
TY - JOUR. T1 - A mass spectrometry approach for the identification and localization of small aldehyde modifications of proteins. AU - Afonso, Catarina B.. AU - Sousa, Bebiana C.. AU - Pitt, Andrew R.. AU - Spickett, Corinne M.. N1 - © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: European Unions Horizon 2020 research and innovation programme under the Marie Sklowdowska-Curie grant agreement number 675132. PY - 2018/5/15. Y1 - 2018/5/15. N2 - Lipids containing polyunsaturated fatty acids are primary targets of oxidation, which produces reactive short-chain aldehydes that can covalently modify proteins, a process called lipoxidation. Improved mass spectrometry (MS) methods for the analysis of these adducts in complex biological systems are needed. Lysozyme and human serum albumin (HSA) were used as model proteins to investigate lipoxidation products formed by two short-chain aldehydes, acrolein and pentanal, which are ...
MSACL is a non-profit association committed to the advancement of mass spectrometry and the development of new technologies to enhance patient care through education and training of practitioners, physicians, laboratory scientists, industrial scientists, and health care professionals.
MSACL is a non-profit association committed to the advancement of mass spectrometry and the development of new technologies to enhance patient care through education and training of practitioners, physicians, laboratory scientists, industrial scientists, and health care professionals.
This protocol presents an integrated Raman spectroscopy-mass spectrometry (MS) platform that is capable of achieving single-cell...
Many analytical approaches such as mass spectrometry generate large amounts of data (input variables) per sample analysed, and not all of these variables are important or related to the target output of interest. The selection of a smaller number of variables prior to sample classification is a widespread task in many research studies, where attempts are made to seek the lowest possible set of variables that are still able to achieve a high level of prediction accuracy; in other words, there is a need to generate the most parsimonious solution when the number of input variables is huge but the number of samples/objects are smaller. Here, we compare several different variable selection approaches in order to ascertain which of these are ideally suited to achieve this goal. All variable selection approaches were applied to the analysis of a common set of metabolomics data generated by Curie-point pyrolysis mass spectrometry (Py-MS), where the goal of the study was to classify the Gram-positive ...
This is a graduate course in organic spectroscopy, focusing on modern methods used in structure determination of organic molecules. Topics include mass spectrometry; ultraviolet, chiroptical, infrared, and nuclear magnetic resonance spectroscopy.
The highly versatile Liquid Chromatography-Mass Spectrometry instrument illustrated here can separate and quantify analytes as diverse as vitamins and minerals, mycotoxins and illegal dyes. Read more...
This unusual text is not simply a compilation of mass spectrometric methods but provides, instead, insight into specific approaches mass spectroscopists use when applying the technique to a variety of biological problems. Each chapter provides guidance in using the appropriate methods for isolating and purifying the compound class prior to mass spectrometric analysis. Covered in-depth are the mass spectrometry of carbohydrates, peptide sequencing by mass spectrometry, mass spectrometry of nucleic acid components, and mass spectrometry in pharmacology. This definitive look at a growing facet of the science is an essential reference for biochemists, biological chemists, bioanalytical chemists, and students. 1990 (0-471-61303-7) 396 pp ...
Anal Chem. 2014 Sep 16;86(18):9204-11. Epub 2014 Aug 26.. The combination of mass spectrometry imaging and histology has proven a powerful approach for obtaining molecular signatures from specific cells/tissues of interest, whether to identify biomolecular changes associated with specific histopathological entities or to determine the amount of a drug in specific organs/compartments. Currently there is no software that is able to explicitly register mass spectrometry imaging data spanning different ionization techniques or mass analyzers. Accordingly, the full capabilities of mass spectrometry imaging are at present underexploited. Here we present a fully automated generic approach for registering mass spectrometry imaging data to histology and demonstrate its capabilities for multiple mass analyzers, multiple ionization sources, and multiple tissue types.. http://dx.doi.org/10.1021/ac502170f ...
Clinical Mass Spectrometry Course Series This series of courses is designed for anyone in the clinical laboratory field who wants to learn about mass spectrometry and utilize this technology in the clinical laboratory. Medical laboratory scientists with training in mass spectrometry are in demand in the clinical laboratory.
Lee, A.E.; Geis-Asteggiante, L.; Dixon, E.K.; Kim, Y.; Kashyap, T.R.; Wang, Y.; Fushman, D.; Fenselau, C., 2016: Preparing to read the ubiquitin code: characterization of ubiquitin trimers by top-down mass spectrometry
This UPLC-FLR/MS system represents a robust tool for separation and analysis of minor glycoforms or isomers that are otherwise difficult to assign.
After the successful inaugural conference in IICT, Hyderabad last year, this conference has been conceptualized to discuss the advanced techniques and applications of Mass Spectrometry. The experts in this conference will cover various advanced techniques followed by novel applications of Mass Spectrometry in analysis of Pharmaceutical and Forced Degradation products, Metabolites, Food, Environment, Forensic, Clinical and Biological samples. This event will provide you with excellent opportunity to enhance your knowledge on Mass Spectrometry as well as learn the advanced applications in different fields. Further, this event will also help in networking with like minded peers, helping you to build new relationships and optimize your workflow ...
A community of practice on mass spectrometry imaging (MSI) emerged 2012 under the auspices of the European network COST Action BM1104 which aimed at connecting scientist working in the rapidly growing field of MSI. The European nature of the COST funding has meant these early activities (conferences, workshops, training courses) had an European focus but they were open to worldwide participation. Consequently, the community had over 200 active members from all continents.. It was decided in October 2015 to formally establish a Mass Spectrometry Imaging Society to continue the activities of the COST network and to include other activities and all practitioners in the field of MS imaging. The possibility to join an existing society, e.g. to form a focus group within the International Mass Spectrometry Foundation (IMSF) was evaluated and discussed during 2016. As a result of extensive discussions during OurCon IV (Ustron, Poland, October 2016) it was almost unanimously decided to form the Mass ...
Spectralworks AnalyzerPro MS data processing software features and benefits. GC MS and LC MS data processing and deconvolution, qualitative and quantitative analysis
TY - JOUR. T1 - Determination of technetium-99 and neptunium-237 in environmental samples by inductively coupled plasma mass spectrometry. AU - Sumiya, Sh. AU - Morita, Sh. AU - Tobita, K.. AU - Kurabayashi, M.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - New analytical techniques using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) were applied to the determination of technetium-99 (Tc-99) and neptunium-237 (Np-237) in environmental samples. The determination of Tc-99 consists of a cyclohexanone solvent extraction method to eliminate the interference isobar (Ru-99). An anion exchange with acetic acid media and a TTA-xylene solvent extraction were used for the determination of Np-237. Technetium-95m and Np-239 were used as chemical recovery tracers in these methods. The concentrations of Tc-99 and Np-237 in the typical surface soil samples in Japan ranged form 8.1×102 to 1.8×10-1 Bq/kg-dry, from 3.3×10-3 to 8.0×10-3 Bq/kg-dry, respectively.. AB - New analytical techniques using Inductively ...
Provides students with an overview of protein bioinformatics including computational and experimental approaches. The course will introduce amino acid and protein physical properties as well as the alignment and evolution of protein sequences. Protein structure and methods of structure determination will be presented as well as the use of protein databases and software for visualizing proteins. Methods for secondary and tertiary protein structure prediction will be discussed as well as methods for modeling small/molecule-protein interactions and protein-protein interactions. The course will also cover mass spectrometry and the analysis of high-throughput mass spectrometry data. A survey of mass spectrometry ionization techniques and instrument types will be followed by an overview of data analysis techniques for protein identification, de novo protein sequencing, and the analysis of post-translational modifications. Finally, students will be introduced to experimental and computational aspects ...
Denne protokol præsenterer en integreret Raman spektroskopi-Mass massespektrometri (MS) platform, der er i stand til at opnå en enkelt...
A&M has a known competence in mass spectrometry ever since its foundation in 1990, which is based on constant investments in state of the art equipment as well as the education of our employees.. At the beginning we were only using mass-selective detectors in combination with gas chromatography; now we are applying different powerful mass spectrometers to a wide range of projects. This is why we use ion-trap, time-of-flight (ToF) and orbital-trap mass spectrometers coupled to HPLC- /UPLC- or ion chromatography systems. Our mass spectrometry unit consists of eight highly qualified specialists, of which four are PhD-level scientists.. Mass spectrometry has long gained access to the regulated GMP environment. We offer our clients an exclusive pharmaceutical mass spectrometry service, which has been acknowledged in several authority audits. ...
Research areas such as proteomics and metabolomics are driving the demand for mass spectrometers that have high performance but modest power requirements, size, and cost. This paper describes such an instrument, the Orbitrap, based on a new type of mass analyzer invented by Makarov. The Orbitrap operates by radially trapping ions about a central spindle electrode. An outer barrel-like electrode is coaxial with the inner spindlelike electrode and mass/charge values are measured from the frequency of harmonic ion oscillations, along the axis of the electric field, undergone by the orbitally trapped ions. This axial frequency is independent of the energy and spatial spread of the ions. Ion frequencies are measured non-destructively by acquisition of time-domain image current transients, with subsequent fast Fourier transforms (FFTs) being used to obtain the mass spectra.. In addition to describing the Orbitrap mass analyzer, this paper also describes a complete Orbitrap-based mass spectrometer, ...
Conventional methods for analysis of trace volatile organic compounds (VOCs) in air, soil, and water usually involve significant sample preparation followed by slow chromatographic analysis. Direct mass spectrometry (DMS) provides opportunities for simplification - or even elimination - of sample preparation, plus real-time or high-throughput sample analysis. This webinar will introduce selected ion flow tube mass spectrometry (SIFT-MS), a DMS technique that provides highly sensitive and selective analysis of a wide range of compounds by applying eight rapidly switchable soft chemical ionization agents. Diverse VOCs (such as benzene and formaldehyde) and inorganic gases (such as sulfur dioxide and hydrogen sulfide) are detected in a single, simple analysis. Various environmental applications of SIFT-MS will be discussed, ranging from real-time ambient air monitoring to high-throughput soil and water analysis. ...
No. of Report Pages: 129. Price of Report (single User Licence): $ 3500. Purchase the Report at: http://www.absolutereports.com/purchase/10516774. The Global Clinical Mass Spectrometry Market Professional Survey Report 2017 highlights key dynamics of Clinical Mass Spectrometry sector. The current market scenario and future prospects of the sector has also been studied. Additionally, prime strategical activities in the market which includes product developments, mergers and acquisitions, partnerships, etc., are discussed.. Get Discount on Purchase of this Report at: http://www.absolutereports.com/enquiry/request-discount/10516774. The research report has offered answers to several important questions related to the growth of the Clinical Mass Spectrometry market. Some of them are given below:. • Which product segment is projected to lead in the Clinical Mass Spectrometry market?. • What is the expected growth rate of the Clinical Mass Spectrometry market in the near future?. • Which region ...
Article In-situ investigation of the cathode catalysts for PEM fuel cells using differential electrochemical mass spectrometry. Differential electrochemical mass spectrometry (DEMS) involves applying a potential across an electrochemical cell and mea...
The hydroxyl free radical (OH) is the major oxidizing species in the lower atmosphere. Measuring the OH concentration is generally difficult and involves elaborate, expensive, custom-made experimental setups. Thus other more economical techniques, capable of determining OH concentrations at environmental chambers, would be valuable. This work is based on an indirect method of OH concentration measurement, by monitoring an appropriate OH tracer by proton transfer reaction mass spectrometry (PTR-MS). 3-pentanol, 3-pentanone and pinonaldehyde (PA) were used as OH tracers in α-pinene (AP) secondary organic aerosol (SOA) aging studies. In addition we tested butanol-d9 as a potential "universal" OH tracer and determined its reaction rate constant with OH: k butanol-d9 = 3.4(±0.88) × 10 -12 cm 3 molecule -1 s -1. In order to make the chamber studies more comparable among each other as well as to atmospheric measurements we suggest the use of a chemical (time) dimension: the OH clock, which ...
The authors have developed a clever solution to be able to provide constant resolution, high-resolution mass spectrometry data across the full spectrum. In doing so, they have assigned 244,779 unique elemental compositions: a record.
Waters SYNAPT and Vion systems combine ion mobility separations with high resolution MS, significantly enhancing routine MS/MS workflows, enabling new discoveries not possible any other way
The molecular mass (m) is the mass of a given molecule: it is measured in unified atomic mass units (u or Da).[1][2] Different molecules of the same compound may have different molecular masses because they contain different isotopes of an element. The related quantity relative molecular mass, as defined by IUPAC, is the ratio of the mass of a molecule to the unified atomic mass unit and is unitless. The molecular mass and relative molecular mass are distinct from but related to the molar mass. The molar mass is defined as the mass of a given substance divided by the amount of a substance and is expressed in g/mol. The molar mass is usually the more appropriate figure when dealing with macroscopic (weigh-able) quantities of a substance. The definition of molecular weight is most authoritatively synonymous with molecular mass; however, in common practice, it is also highly variable as are the units used in conjunction with it. Many common preparatory sources use g/mol and effectively define it as ...
A new method for the detection of gas-phase hydroperoxides is described. The clustering chemistry of CF3O- is exploited to produce speciated measurements of several hydroperoxides with high sensitivity and fast time response. Correspondence of airborne observations made with this technique and the established HPLC method is illustrated. CF3O- appears to be a highly versatile reagent ion for measurements of both weak and strong acids in the atmosphere.. ...
Genetic information is rapidly transforming the future of healthcare by enabling accurate and affordable diagnosis and prognosis, targeted treatments, and monitoring solutions.
Watch out for our scientific contributions at the ASMS annual meeting, taking place in Minneapolis, MN. We will present new results as scientific posters.
Sigma-Aldrich offers abstracts and full-text articles by [Vera Muccilli, Rosaria Saletti, Vincenzo Cunsolo, Jenny Ho, Elisa Gili, Enrico Conte, Stefania Sichili, Carlo Vancheri, Salvatore Foti].
The ISIC-EPFL mass spectrometry platform team present a poster at the American society of mass spectrometry (ASMS2020) annual conference. Unfortunately,…. ...
The goal is to provide students with a complete overview of the principles and key applications of modern mass spectrometry and meet the current practical demand of EPFL researchers to improve structural analsis of molecules. Numerous instrumental aspects of mass spectrometry are described ...
Increasing Size, Complexity and Potency: The Bioanalytical Challenge of the Next Decade, was the theme for the 3-day APA India held in Mumbai, India from February 23-25, 2015. Close to 300 attendees gathered to discuss… Read more > ...
Stadlmeier, M. ; Bogena, J. ; Wallner, M. ; Wühr, M. ; Carell, T. A sulfoxide-based isobaric labelling reagent for accurate quantitative mass spectrometry. Angewandte Chemie 2018.
Inclusion list driven mass spectrometry calls for a list of mass ranges to be included from the chromatography separation. These lists are generated from elution time standards and allow from a specific size protein to be included in a mass spectrometry analysis. Target protein information is then passed to a tandem MS (MS/MS) where the first quadrupole restricts for the desired target and the second quadrupole analyzes that target. An opposite strategy called exclusion list driven mass spectrometry is used to prevent a specific size from being included and allows for a certain, previously determined protein to be ignored. The information gained from directed mass spectrometry can be used for comparative analysis of differentially expressed proteins. It allows for quantification of a certain protein from a certain proteome. This information can be used to differentiate disease-state cells from normal cells ...
Disclaimer: This material is being kept online for historical purposes. Though accurate at the time of publication, it is no longer being updated. The page may contain broken links or outdated information, and parts may not function in current web browsers. Visit espo.nasa.gov for information about our current projects.. ...
A wide range of mass spectrometry techniques and measurements are available for air, carbon dioxide, carbon monoxide, nitrous oxide, water, carbonates, organics, and other specific isotopes.
Top-down analysis of protein samples by de novo> sequencing techniques. Energy Technology Data Exchange (ETDEWEB). Vyatkina, Kira; Wu, Si; Dekker, Lennard J. M.; VanDuijn, Martijn M.; Liu, Xiaowen; Tolić, Nikola; Luider, Theo M.; Paša-Tolić, Ljiljana; Pevzner, Pavel A.. 2016-05-14. MOTIVATION: Recent technological advances have made high-resolution mass spectrometers affordable to many laboratories, thus boosting rapid development of top-down mass spectrometry, and implying a need in efficient methods for analyzing this kind of data. RESULTS: We describe a method for analysis of protein samples from top-down tandem mass spectrometry data, which capitalizes on de novo sequencing of fragments of the proteins present in the sample. Our algorithm takes as input a set of de novo amino acid strings derived from the given mass spectra using the recently proposed Twister approach, and combines them into aggregated strings endowed with offsets. The former typically constitute accurate sequence ...
As an initiative of the recently formed ASMS Diversity and Outreach Working Group, the editors are pleased to introduce a new "Faces of Mass Spectrometry" interview series in the Journal of the American Society of Mass Spectrometry. The goal of this series is to highlight the diversity of ASMS members, as well as to demonstrate the various paths that one can undertake to achieve a career in mass spectrometry. An animated conversation with Diversity and Outreach Working Group member Dr. Livia Eberlin introduced science writer Kristin Phillips to the astounding capability of mass spectrometry and sparked this series of conversations with innovative, creative scientists of ASMS. Phillips, a Science and Health writer at the University of Texas at Austin, lives to discover new worlds both in her own research observing primate social relationships and by interviewing hundreds of climate scientists, archaeologists, paleontologists and nutritionists. Click Here to view this months Face of Mass ...
Researchers that use instruments acquired with National Institutes of Health (NIH) funds must list the NIH grant number in the acknowledgement section of any manuscript that contains data from the instruments, NOT in the supplemental information section. Yes, the instrument used for mass spectrometry should be named in the supplemental information section if that is where all the experimental details are, but the award number needs to be in the acknownledgement paragraph. NIH, via PubMed Central (PMC), searches for its award numbers to build the case that their money (tax payer money) is being used very productively to promote research.. All spectra coming from the CIC Mass Spectrometry Facility have the name of the instrument that generated them printed on them. Currently the only mass spectrometers acquired with NIH funds are the Bruker ULTRAFLEX® III and the Thermo Q Exactive™ Plus.. If any mass spectrometry data is used in a manuscript, then one or more of the following sentences may be ...
300359944 - EP 1239288 A1 2002-09-11 - Identification of nucleotides by mass spectrometry - A method for correlating a peptide fragment mass spectrum with amino acid sequences derived from a database is provided. A peptide is analyzed by a tandem mass spectrometer to yield a peptide fragment mass spectrum. A protein sequence database or a nucleotide sequence database is used to predict one or more fragment spectra for comparison with the experimentally-derived fragment spectrum. In one embodiment, sub-sequences of the sequences found on the database which define a peptide having a mass substantially equal to the mass of the peptide analyzed by the tandem mass spectrometer are identified as candidate sequences. For each candidate sequence, a plurality of fragments of the sequence are identified and the masses and m/z ratios of the fragments are predicted and used to form a predicted mass spectrum. The various predicted mass spectra are compared to the experimentally derived fragment spectrum using a
The mass spectrometry instrumentation the Kane Lab are using to develop new methodology and interrogate biological problems are based in the University of Maryland School of Pharmacy Mass Spectrometry Center. The Kane lab is a member of the School of Pharmacy Mass Spectrometry Center, where Dr. Kane is the executive director.. See the Mass Spectrometry Centers website for more info on our resources and recent events.. ...