TY - JOUR. T1 - Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. AU - Chen, Meifan. AU - Geoffroy, Cédric G.. AU - Meves, Jessica M.. AU - Narang, Aarti. AU - Li, Yunbo. AU - Nguyen, Mallorie T.. AU - Khai, Vung S.. AU - Kong, Xiangmei. AU - Steinke, Christopher L.. AU - Carolino, Krislyn I.. AU - Elzière, Lucie. AU - Goldberg, Mark P.. AU - Jin, Yishi. AU - Zheng, Binhai. PY - 2018/3/27. Y1 - 2018/3/27. N2 - Reactive astrocytes influence post-injury recovery, repair, and pathogenesis of the mammalian CNS. Much of the regulation of astrocyte reactivity, however, remains to be understood. Using genetic loss and gain-of-function analyses in vivo, we show that the conserved MAP3K13 (also known as leucine zipper-bearing kinase [LZK]) promotes astrocyte reactivity and glial scar formation after CNS injury. Inducible LZK gene deletion in astrocytes of adult mice reduced astrogliosis and impaired glial scar formation, resulting in increased ...
TABLE-US-00001 TABLE 1 Oligo Accession Gene ID Number Number number Gene Name Symbol APOB-10167- 12138 NM_000384 Apolipoprotein B (including Ag(x) antigen) APOB 20-12138 APOB-10167- 12139 NM_000384 Apolipoprotein B (including Ag(x) antigen) APOB 20-12139 MAP4K4-2931- 12266 NM_004834 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 MAP4K4 13-12266 (MAP4K4), transcript variant 1 MAP4K4-2931- 12293 NM_004834 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 MAP4K4 16-12293 (MAP4K4), transcript variant 1 MAP4K4-2931- 12383 NM_004834 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 MAP4K4 16-12383 (MAP4K4), transcript variant 1 MAP4K4-2931- 12384 NM_004834 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 MAP4K4 16-12384 (MAP4K4), transcript variant 1 MAP4K4-2931- 12385 NM_004834 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 MAP4K4 16-12385 (MAP4K4), transcript variant 1 MAP4K4-2931- 12386 NM_004834 Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 MAP4K4 ...
The Caenorhabditis elegans Regulator of Presynaptic Morphology (RPM)-1 is a member of a conserved family of proteins called Pam/Highwire/RPM-1 (PHR) proteins. PHR proteins are key regulators of neuronal development. In C. elegans, RPM-1 (regulator of presynaptic morphology-1) regulates axon termination and guidance in the mechanosensory neurons, and regulates synapse formation in the mechanosensory and motor neurons (Po et al., 2010). In adult C. elegans, RPM-1 also plays a role in axon regeneration in motor neurons (Hammarlund et al., 2009). Importantly, Drosophila Highwire, zebrafish Esrom/Phr1, and murine Phr1 also regulate synapse formation and axon extension highlighting the evolutionarily conserved function of the PHR proteins (Po et al., 2010).. Previous studies showed that RPM-1 functions, in part, as an E3 ubiquitin ligase by binding to the F box SyNaptic protein (FSN)-1 and negatively regulating a MAPK pathway that includes: the Dual Leucine zipper-bearing Kinase (DLK)-1, MAPK Kinase ...
Hsp27, a small heat-shock protein, has important roles in many cellular processes, including cytoskeleton dynamics, cell differentiation, and apoptosis. Its expression in normal epidermis correlates with differentiation; however, little is known about the regulatory mechanisms involved. In this study, we report that Hsp27 undergoes upregulation, phosphorylation, and redistribution to the cytoskeleton during the late phase of epidermal keratinocyte differentiation. Our results also show that the expression of the dual leucine zipper-bearing kinase (DLK), an upstream activator of the MAP kinase pathways, is sufficient by itself to induce Hsp27 phosphorylation, cell periphery localization, and redistribution to the insoluble protein fraction (cytoskeleton) in poorly differentiated keratinocytes. This redistribution correlates with the insolubilization of cornified envelope-associated proteins such as involucrin. Interestingly, the effects of DLK on Hsp27 were blocked by PD98059, a selective ...
Li, Xinli, Chun Liu, Blanche C. Ip, Kang-Quan Hu, Donald E. Smith, Andrew S. Greenberg, and Xiang-Dong Wang. Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. Journal of Experimental & Clinical Cancer Research 34, no. 1 (12, 2015): 1-8 ...
TY - JOUR. T1 - Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. AU - Bahn, Yong Sun. AU - Geunes-Boyer, Scarlett. AU - Heitman, Joseph. PY - 2007/12. Y1 - 2007/12. N2 - The stress-activated p38/Hog1 mitogen-activated protein kinase (MAPK) pathway is structurally conserved in many diverse organisms, including fungi and mammals, and modulates myriad cellular functions. The Hog1 pathway is uniquely specialized to control differentiation and virulence factors in a majority of clinical Cryptococcus neoformans serotype A and D strains. Here, we identified and characterized the Ssk2 MAPKKK that functions upstream of the MAPKK Pbs2 and the MAPK Hog1 in C. neoformans. The SSK2 gene was identified as a potential component responsible for the difference in Hog1 phosphorylation between the serotype D f1 sibling strains B-3501 and B-3502 through comparative analysis of meiotic maps showing their meiotic ...
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
These reference sequences exist independently of genome builds. Explain. These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above. ...
James W. Perfield, Yunkyoung Lee, Gerald I. Shulman, Varman T. Samuel, Michael J. Jurczak, Eugene Chang, Chen Xie, Phillip N. Tsichlis, Martin S. Obin, Andrew S. Greenberg ...
The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals required for eyelid epithelium morphogenesis during mouse fetal development. The present study investigates the role of MEKK1 in epithelial wound healing, another activin-regulated biological process. In a skin wound model, injury markedly stimulates MEKK1 expression and activity, which are in turn required for the expression of genes involved in extracellular matrix (ECM) homeostasis. MEKK1 ablation or down-regulation by interfering RNA significantly delays skin wound closure and impairs activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell-cell junctions of the wounded epidermis. Conversely, expression of wild-type MEKK1 accelerates reepithelialization of full-thickness skin and corneal debridement wounds by mechanisms involving epithelial cell migration, a cell function that is partially abolished by neutralizing antibodies for PAI-1 and
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008 ...
Catalytic domain of the Protein Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6. Serine/threonine kinases (STKs), mitogen-activated protein kinase (MAPK) kinase kinase kinase 4 (MAPKKKK4 or MAP4K4) and MAPKKKK6 (or MAP4K6) subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAP4K4/MAP4K6 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4Ks (or MAPKKKKs) are involved in MAPK signaling pathways that are important in mediating cellular responses to extracellular signals by activating a MAPK kinase kinase (MAPKKK or MAP3K or MKKK). Each MAPK cascade is activated ...
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008 ...
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012 ...
View mouse Map3k15 ChrX:159988433-160123351 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Activator of Chk1/Cdc25C pathway; Inhibitor of the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway; Antidiabetic
TY - JOUR. T1 - Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. AU - Johnson, Nancy Lassignal. AU - Gardner, Anne M.. AU - Diener, Katrina M.. AU - Lange-Carter, Carol A.. AU - Gleavy, Janice. AU - Jarpe, Matthew B.. AU - Minden, Audrey. AU - Karin, Michael. AU - Zon, Leonard I.. AU - Johnson, Gary L.. PY - 1996/2/9. Y1 - 1996/2/9. N2 - Mitogen-activated/extracellular response kinase kinase (MEK) kinase (MEKK) is a serine-threonine kinase that regulates sequential protein phosphorylation pathways, leading to the activation of mitogen-activated protein kinases (MAPK), including members of the Jun kinase (JNK)/stress- activated protein kinase (SAPK) family. In Swiss 3T3 and REF52 fibroblasts, activated MEKK induces cell death involving cytoplasmic shrinkage, nuclear condensation, and DNA fragmentation characteristic of apoptosis. Expression of activated MEKK enhanced the apoptotic response to ultraviolet irradiation, ...
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. MAP2K2 has been shown to interact with MAPK3 and ARAF. GRCh38: Ensembl release 89: ENSG00000126934 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000035027 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Zheng CF, Guan KL (Jun 1993). Cloning and ...
Catalytic domain of fungal Bck1-like MAP Kinase Kinase Kinases. Serine/threonine kinases (STKs), mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) subfamily, fungal Bck1-like proteins, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated ...
We previously demonstrated that bone morphogenetic proteins (BMPs) induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1. Transcription factors Smads mediate transforming growth factor-β signaling and the ATF/CREB family transcription factor ATF-2 has recently been shown to act as a common target of the Smad and the TAK1 pathways. We here examined the role of Smads and ATF-2 in cardiomyocyte differentiation of P19CL6, a clonal derivative of murine P19 cells. Although P19CL6 efficiently differentiates into cardiomyocytes when treated with dimethyl sulfoxide, P19CL6noggin, a P19CL6 cell line constitutively overexpressing the BMP antagonist noggin, did not differentiate into cardiomyocytes. Cooverexpression of Smad1, a ligand-specific Smad, and Smad4, a common Smad, restored the ability of P19CL6noggin to differentiate into cardiomyocytes, whereas stable overexpression of Smad6, an inhibitory Smad, completely blocked differentiation of P19CL6, ...
Exhibits JUN kinase kinase kinase activity. Involved in positive regulation of nervous system development and protein phosphorylation. Predicted to localize to the membrane. Is expressed in diencephalon lateral wall mantle layer; dorsal grey horn; late tubule; midbrain mantle layer; and ureter. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13 ...
Transforming growth factor-β (TGF-β) signals through its receptor, composed of the type I and type II subunits (TβRI and TβRII), to stimulate a pathway involving Smads, as well as Smad-independent signaling. Sorrentino et al. found that in cells transfected with TAK1 [TGF-β-associated kinase 1, a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that is upstream of p38 and ubiquitin], TGF-β1 stimulated the ubiquitylation of TAK1, as well as the phosphorylation of TAK1, which is an indication of activation. When a mutant form of ubiquitin that could not form Lys63-linked chains was transfected into the cells, TAK1 ubiquitylation and phosphorylation, recruitment of TAB2 (TAK-associated binding protein 2), and activation of p38 was diminished. Pharmacological inhibition of TβRI kinase activity failed to block TGF-β-stimulated TAK1 and p38 activation but did block Smad activation, suggesting that activation of the p38 MAPK pathway was independent of the kinase ...
Chicago Mayor Rahm Emanuel this morning declared today Nik Wallenda Day in the city because Wallenda did not plunge to his death last night as he tightrope-walked from skyscraper to skyscraper. Wallendas ratings, however, werent so lucky.
Cell microarrays are a promising tool for performing large-scale functional genomic screening in mammalian cells at reasonable cost, but owing to technical limitations they have been restricted for use with a narrow range of cell lines and short-term assays. Here, we describe MicroSCALE (Microarrays of Spatially Confined Adhesive Lentiviral Features), a cell microarray-based platform that enables application of this technology to a wide range of cell types and longer-term assays. We used MicroSCALE to uncover kinases that when overexpressed partially desensitized B-RAFV600E-mutant melanoma cells to inhibitors of the mitogen-activated protein kinase kinase kinase (MAPKKK) RAF, the MAPKKs MEK1 and 2 (MEK1/2, mitogen-activated protein kinase kinase 1 and 2), mTOR (mammalian target of rapamycin), or PI3K (phosphatidylinositol 3-kinase). These screens indicated that cells treated with inhibitors acting through common mechanisms were affected by a similar profile of overexpressed proteins. In ...
Nik Wallenda, aka the King of the High Wire, is once again proving that theres nothing to fear except fear itself - and falling 1,500 feet into the Grand Canyon without a net or harness. But Wallenda doesnt even fear that.
Nik Wallenda, a seventh-generation member of the Flying Wallenda family, plans to walk a high wire above Baltimore's Inner Harbor on May 9. The stunt will promote a new Ripley's Believe It or Not odditorium and is his last performance before a June 15 walk across Niagara Falls
Trapeze artist Erendira Wallenda, the wife of daredevil Nik Wallenda, performs a jaw-dropping stunt by soaring above Niagara Falls using the strength of her teeth. Rough Cut (no reporter narration).}
MAPK is involved in the action of most nonnuclear oncogenes. It is responsible for cell response to growth factors such as BDNF or nerve growth factor. Extracellular stimuli lead to activation of a MAP kinase via a signaling cascade (MAPK cascade) composed of MAP kinase, MAP kinase kinase (MKK or MAP2K), and MAP kinase kinase kinase (MKKK or MAP3K, EC 2.7.11.25). A MAP3K that is activated by extracellular stimuli phosphorylates a MAP2K on its serine and threonine residues, and then this MAP2K activates a MAP kinase through phosphorylation on its serine and tyrosine residues. This MAP kinase signaling cascade has been evolutionarily well-conserved from yeast to mammals. ...
Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant A, mRNA. (H00006885-R01V) - Products - Abnova
Homo sapiens mitogen-activated protein kinase kinase kinase 4 (MAP3K4), transcript variant 1, mRNA. (H00004216-R06) - Products - Abnova
Gene target information for MAP3K20 - mitogen-activated protein kinase kinase kinase 20 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
ASK1 (phospho Ser966) antibody (mitogen-activated protein kinase kinase kinase 5) for IHC-P, WB. Anti-ASK1 (phospho Ser966) pAb (GTX50229) is tested in Human, Mouse samples. 100% Ab-Assurance.
au08-06_mpk6_heat_stressed - au08-06_mpk6_heat_stressed - Mitogen Activated Protein Kinase (MAPK) signaling pathways are key regulators of cell proliferation, differentiation and stress effectors. The core of the MAP kinase signal transduction cascade is composed of a three-kinase module consisting of a MAP kinase kinase kinase (MAPKKK), a MAP kinase kinase (MAPKK), and a MAP kinase (MAPK). The signaling pathway is activated upon stimulation by a phosphorylation cascade. In previous studies, it was shown that the mpk6 KO mutant plants are significantly more tolerant to heat stress in comparison to wt and that after 3h treatment at 37°C, an activation of heat-shock proteins occures in the mpk6 mutant. To better understand the changes occuring in the mpk6 mutant upon heat stress at the gene expression level, we would like to perform a microarray transcriptomic analysis. - Mitogen Activated Protein Kinase (MAPK) signaling pathways are key regulators of cell proliferation, differentiation and stress
Nik a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB ...
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Zajmujemy się projektowaniem, sprzedażą, a także montażem mebli kuchennych. Na stronie znajdą państwo naszą ofertę, a także już zrealizowane projekty. Prowadzimy także sprzedaż frontów kuchennych w bardzo atrakcyjnych cenach.
Zajmujemy się projektowaniem, sprzedażą, a także montażem mebli kuchennych. Na stronie znajdą państwo naszą ofertę, a także już zrealizowane projekty. Prowadzimy także sprzedaż frontów kuchennych w bardzo atrakcyjnych cenach.
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Product Page for DIM 200 mg 120 Tabs made by source-naturals offering price, ingredients and full item description from betterlife
DISCONTINUED BY MANUFACTURER. FOR YOUR INFORMATION PURPOSES, WE HAVE KEPT THIS ITEM PLACEMENT AS COURTESY TO OUR CUSTOMERSYou may search for a related or...
Cancer of the breast is known to be among the top spreading diseases on the globe. Triple-negative breast cancer is painstaking the most destructive type of mammary tumor because it spreads faster to other parts of the body, with high chances of early relapse and mortality. This research would aim at utilizing computational methods like quantitative structure-activity relationship (QSAR), performing molecular docking studies and again to further design new effective molecules using the QSAR model parameters and to analyze the pharmacokinetics
MELK (Maternal embryonic leucine zipper kinase) belongs to the CAMK serine/threonine protein kinase superfamily. Melk is a protein serine/threonine kinase that is maximally active during mitosis. It is involved in diverse functions such as cell cycle, cytokinesis, mRNA splicing and apoptosis. Expression MELK is expressed in cells of various tissue origins. MELK expression is strongly dependant on cell-cycle: MELK is undetectable in cells which have exited cell cycle. The exact function of MELK is currently unknown, however MELK was shown to be involved in cell cycle progression via the protein phosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis via its interaction with the Bcl-2 family of proapoptotic genes and apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association with NIPP1. MELK function is required for mammary tumorigenesis in vivo.. ...
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis ...
TY - JOUR. T1 - The cytoplasmic domain of Alzheimers amyloid-β protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH 2-terminal kinase-mediated neurotoxic signal via dimerization. AU - Hashimoto, Yuichi. AU - Niikura, Takako. AU - Chiba, Tomohiro. AU - Tsukamoto, Emi. AU - Kadowaki, Hisae. AU - Nishitoh, Hideki. AU - Yamagishi, Yohichi. AU - Ishizaka, Miho. AU - Yamada, Marina. AU - Nawa, Mikiro. AU - Terashita, Kenzo. AU - Aiso, Sadakazu. AU - Ichijo, Hidenori. AU - Nishimoto, Ikuo. PY - 2003/9/1. Y1 - 2003/9/1. N2 - The biological function of full-length amyloid-β protein precursor (AβPP), the precursor of Aβ, is not fully understood. Multiple laboratories have reported that antibody binding to cell surface AβPP causes neuronal cell death. Here we examined whether induced dimerization of the cytoplasmic domain of AβPP (AβPPCD) triggers neuronal cell death. In neurohybrid cells expressing fusion constructs of the epidermal growth factor (EGF) receptor with ...
The purpose of Phase I of this study is to test the safety and tolerability of the investigational drug, OTS167, and that of Phase II of this study is to confirm the potential response benefit of OTS167.. OTS167 is a maternal embryonic leucine zipper kinase (MELK) inhibitor which demonstrated antitumor properties in laboratory tests. It is being developed as an anti-cancer drug. In this study OTS167 will be administrated to patients with AML, ALL, advanced MDSs, advanced MPNs, or advanced CML. ...
Next-day shipping cDNA ORF clones derived from MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 available at GenScript, starting from $99.00.
Map3k3 - Lenti ORF clone of Map3k3 (mGFP-tagged) - Mouse mitogen-activated protein kinase kinase kinase 3 (Map3k3) available for purchase from OriGene - Your Gene Company.
Blood pressures of ASK2KO were significantly decreased by salt loading, although those of WT were not. Increased cardiac fibrosis and inflammatory cell infiltration observed in normal diet ASK2KO were also significantly decreased by salt loading. This shows that hypertension and cardiac hypertrophy in ASK2KO are salt resistant. Salt loading increased ASK2 mRNA in the heart tissues of WT, and it enhanced the inflammatory responses, oxidative stress and TGFβ expression in WT hearts, but these effects were not observed in ASK2KO, which indicates that ASK2 is involved in salt induced cardiac injury.. Conclusions: ...
MAP3K5 Full-Length MS Protein Standard (NP_005914), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress
Recombinant human TAOK2 (amino acids 1-314) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Thousand and one-amino acid protein kinase 2 (TAOK 2) is part of the stress-sensitive kinase cascade and activation of and binding to MKK3 by TAOK2 implicates it in the regulation of the p38-containing stress-responsive MAP kinase pathway. TAOK2 protein kinase activates p38 mitogen-activated protein kinase cascade in vitro and in cells by phosphorylating the MAP/ERK kinases MKK3 and MKK6.
Mitogen-activated protein kinase (MAPK) cascades are conserved signal transduction pathways in all eukaryotic organisms. MAPKKKs (MAPK kinase kinases) operate at the top levels of these cascades. Recently, this family of genes has been systematically investigated in Arabidopsis, rice and maize, but has not yet been characterized in cotton. In this study, we identified 78 putative MAPKKK genes in the genome of the diploid cotton, Gossypium raimondii. They were classified into three subfamilies, of which 12 were ZIK, 22 were MEKK and 44 were Raf. The ZIK and MEKK genes displayed a scattered genomic distribution across 11 of the 13 chromosomes, whereas Raf genes were distributed across the entire genome. Their conserved patterns observed for introns and additional domains were consistent with the evolutionary relationships inferred from the phylogenetic analysis within subfamily. Transcriptome sequencing data were used to investigate their transcript profiles in mature leaves, 0 day and 3 days post
TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a…
CAMERON, Ariz. (AP) - Florida aerialist Nik Wallenda has planned his highest tightrope walk yet, and he says hell do it without a harness.
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Jangan tertipu taw, memang la dia tulis rendah lemak, tapi anda tahu kan, lemak lha penyedap makanan. Semakin banyak lemak, semakin sedaplah makanan itu (fakta). So kalau rendah lemak? Mestilah tak berapa sedap kan? Kalau tak berapa sedap, mesti lepas tu ramai orang tak nak beli kan? So untuk mengelakkan perkara itu, pengusaha makanan itu akan menambah perasa tiruan, garam, gula dan macam-macam ...
I want all the file tabs in Sublime text to be of uniform size that increase or decrease uniformly depending on the number of tabs that are added or removed (Like how tabs work in Google Chrome). Currently the size of the tab changes according to the length of the file name that is open in that tab. This results in uneven sized tabs. I am currently using the Default Sublime theme Adaptive.sublime-theme. I tried adding the tab_width property to this theme but it didnt make any difference.. ...
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