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Stavanger is the fourth largest city of Norway with a population of 126 021 within city proper as of January 1, 2011. It is in the south-western coast of the country. The urban area of Stavanger stretches across many neighboring municipalities, making it the third largest city in Norway by total urban population with 197 852 inhabitants as of January 1, 2011 [http://www.ssb.no/beftett/tab-2011-06-17-01.html].
Stavanger is the fourth largest city of Norway with a population of 126 021 within city proper as of January 1, 2011. It is in the south-western coast of the country. The urban area of Stavanger stretches across many neighboring municipalities, making it the third largest city in Norway by total urban population with 197 852 inhabitants as of January 1, 2011 [http://www.ssb.no/beftett/tab-2011-06-17-01.html].
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase. Serine/Threonine Kinases (STKs), p38alpha subfamily, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta. p38alpha, also called MAPK14, is expressed in most tissues and is ...
The rest of the documentation details each of the object methods. Internal methods are preceded with an underscore. new Title : new Usage : my $icm = TFBS::Matrix::ICM-,new(%args) Function: constructor for the TFBS::Matrix::ICM object Returns : a new TFBS::Matrix::ICM object Args : # you must specify either one of the following three: -matrix, # reference to an array of arrays of integers #or -matrixstring,# a string containing four lines # of tab- or space-delimited integers #or -matrixfile, # the name of a file containing four lines # of tab- or space-delimited integers ####### -name, # string, OPTIONAL -ID, # string, OPTIONAL -class, # string, OPTIONAL -tags # an array reference, OPTIONAL to_PWM Title : to_PWM Usage : my $pwm = $icm-,to_PWM() Function: converts an information content matrix (a TFBS::Matrix::ICM object) to position weight matrix. At present it assumes uniform background distribution of nucleotide frequencies. Returns : a new TFBS::Matrix::PWM object Args : none; in the future ...
1. Raman M, Chen W, Cobb M.H. Differential regulation and properties of MAPKs. Oncogene. 2007;26(22):3100 2. IƱesta-Vaquera F, Sabio G, Kuma Y, Cuenda A. Alternative p38 Pathways MAPK. Stress-Activated Protein Kinases. Heidelberg: Springer Berlin. 2008:17 3. Adams R.H. et al. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell. 2000;6(1):109 4. Allen M. et al. Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000;191(5):859 5. Mudgett J.S. et al. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000;97(19):10454 6. Tamura K. et al. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000;102(2):221 7. Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. ...
In this study we report the activation of c-Jun N-terminal kinase (JNK) in human K562 erythroleukemia cells undergoing hemin-mediated erythroid differentiation, which occurs concomitantly with activation of heat shock factor 2 (HSF2) and leads to a simultaneous in vivo phosphorylation of c-Jun. The activation of JNK occurs through activation of mitogen-activated protein kinase kinase (MKK) 4 and not by activation of MKK7 or inhibition of JNK-directed phosphatases. We have previously shown that overexpression of the HSF2-beta isoform inhibits the activation of HSF2 upon hemin-induced erythroid differentiation. Here we demonstrate that HSF2-beta overexpression blocks the hemin-induced activation of the MKK4-JNK pathway, suggesting an erythroid lineage-specific JNK activation likely to be regulated by HSF2. ...
MAPK is involved in the action of most nonnuclear oncogenes. It is responsible for cell response to growth factors such as BDNF or nerve growth factor. Extracellular stimuli lead to activation of a MAP kinase via a signaling cascade ("MAPK cascade") composed of MAP kinase, MAP kinase kinase (MKK or MAP2K), and MAP kinase kinase kinase (MKKK or MAP3K, EC 2.7.11.25). A MAP3K that is activated by extracellular stimuli phosphorylates a MAP2K on its serine and threonine residues, and then this MAP2K activates a MAP kinase through phosphorylation on its serine and tyrosine residues. This MAP kinase signaling cascade has been evolutionarily well-conserved from yeast to mammals. ...
SEK1 / MKK4 (phospho Ser80) antibody (mitogen-activated protein kinase kinase 4) for ICC/IF, IHC-P, WB. Anti-SEK1 / MKK4 (phospho Ser80) pAb (GTX55115) is tested in Human samples. 100% Ab-Assurance.