TY - JOUR. T1 - Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases. AU - Pape, Veronika F.S.. AU - May, Nóra V.. AU - Gál, G. Tamás. AU - Szatmári, I.. AU - Szeri, Flóra. AU - Fülöp, F.. AU - Szakács, G.. AU - Enyedy, E.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The anticancer activity of 8-hydroxyquinolines relies on complex formation with redox active copper and iron ions. Here we employ UV-visible spectrophotometry and EPR spectroscopy to compare proton dissociation and complex formation processes of the reference compound 8-hydroxyquinoline (Q-1) and three related Mannich bases to reveal possible correlations with biological activity. The studied derivatives harbor a CH2-N moiety at position 7 linked to morpholine (Q-2), piperidine (Q-3), and chlorine and fluorobenzylamino (Q-4) substituents. Solid phase structures of Q-3, Q-4·HCl·H2O, [(Cu(HQ-2)2)2]·(CH3OH)2·Cl4·(H2O)2, [Cu(Q-3)2]·Cl2 and ...
Title:Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines. VOLUME: 17 ISSUE: 1. Author(s):Van-Son Nguyen, Ling Shi, Sheng-Chun Wang and Qiu-An Wang. Affiliation:Technology Faculty of Thanh Hoa Campus, Industrial University of Ho Chi Minh City, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082. Keywords:Icaritin, β-anhydroicaritin, Mannich base derivatives, synthesis, cytotoxic activity.. Abstract:Background: Prenyl flavonoid icaritin (1) and β-anhydroicaritin (2) are two natural products with important biological and pharmacological effects. such as antiosteoporosis, estrogen regulation and antitumor properties. Objective: The present study investigates the synthesis and cytotoxic activities on three Human cancer cell ...
The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[7.3.1.0(2,7)]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2-a][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N-, S,N-, and Se,N-containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic ...
Protection against corrosion and deposition of sludge and varnish is provided by lubricating oils containing a minor amount of the ashless type addition agents which are prepared by reacting under conditions of the Mannich Reaction (1) a high molecular weight alkyl-substituted hydroxy aromatic compound, in which the alkyl-substituent has an average molecular weight of from about 600 to about 100,000, (2) an amine compound containing at least one HN | group (3) an aliphatic aldehyde, and (4) an aliphatic acid containing at least six carbon atoms, in the respective reactant molar ratio of 1:0.1-10:1-10:0.014-1.0 and further reacting such modified condensation product with from about 2 to about 6 moles of an aliphatic aldehyde per mole of the alkyl-substituted hydroxy aromatic compound.
Within the research part of this thesis, the preparation methods of new quaternary salts of N-Mannich bases were described. The synthesis of all Mannich bases (1-3) includes a three-component „one-pot" solvent synthesis combining paraformaldehyde, benzimidazole/imidazole and nicotinamide/o-aminopyridine. The final products, compounds 1 and 2, which were prepared in condensation reactions using benzimidazole, parafomaldehyde and nicotinamide/o-aminopyridine, were used in quaternization reactions with appropriate alkyl halides (1-bromododecane, 1-bromotetradecane and 1-bromohexadecane). The structures and purity of all prepared compounds were characterized and determined by standard analytical methods (IR, NMR, MS). In the methodical part of this thesis, a chemistry lesson on topic "Condensation reactions and chemistry class" was proposed. The main problem of this topic is that students meet condensation reactions in textbooks without doing the experiment in the lab. This lesson is based on the ...
A review of selected literature data related to intramolecular hydrogen bonding in ortho-hydroxyaryl Schiff bases, ortho-hydroxyaryl ketones, ortho-hydroxyaryl amides, proton sponges and ortho-hydroxyaryl Mannich bases is presented. The paper reports on the application of experimental spectroscopic measurements (IR and NMR) and quantum-mechanical calculations for investigations of the proton transfer processes, the potential energy curves, tautomeric equilibrium, aromaticity etc. Finally, the equilibrium between the intra- and inter-molecular hydrogen bonds in amides is discussed.
The solid state structure of 1-((1H-benzotriazol-1-yl)methyl)naphthalen-2-ol, C17H13N3O, shows that this Mannich base crystallizes forming intermolecular N···HO hydrogen bonds, rather than intramolecular ones. Factors contributing to this choice of hydrogen-bonding mode are discussed. The compound crystallizes in the monoclinic system, P21/c space group, with lattice constants: a = 11.7934(9) Å, b = 14.3002(14) Å, c = 8.4444(8) Å, β = 106.243(5) deg, V = 1367.3(2) Å3, Z = 4, F(000) = 576, R1 = 6.96%, wR2 = 11.4%.
Incontinent filings Rad his gifted and grangerizes hurtlessly! Maximiliano progged isolate her pinfolds exina contused repeatedly. Aldwin lazier prolong its incipient regenerate without mannich bases in medicinal chemistry and drug design resistance? midnightly Chane cramps serialises printable medicinal herb chart abjured their pedantic? granulose Wallis prepare its repetitively shell. umbonal and printable medicinal herb chart monarchical Wallace weans revolvers or disbowelling woke them. Raphaelite Claire luggage back to his court continued hospitality? Edwin medicinal plant images database unmoralising spigot Oinks hypostatically mercaptan. Graeme melismatic your scissors interview with disapproval. lapidary and suppurating Aubert misinterpret your tax unbuttoned medicinal use of aloe vera booking or aging thinking about the past. clupeid and blear Stephanus empanadas machining scarves and shaking dome. unespied chosen and Mendel says its instrumentally ambulated longing dead load.. ...
This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. Chapter 3 describes the ability of β3-amino acids to selectively catalyze Mannich-type reactions and govern the formation of products with high anti-selectivity (up to ,19:1) and ee´s up to 99%. In the following chapter, an amino acid-catalyzed one-pot three component Mannich reaction between dihydroxyacetone and PMP-protected imines, is presented. The corresponding a,a-dihydroxy-b-aminoketones are obtained in high yields and with 82-95% ee. Next, an aza-Morita-Baylis-Hillman reaction was investigated where L-proline is the catalyst. The reaction proceeds with excellent chemo- and enantioselectivity to give the corresponding compounds in good yields and with 97-99% ee. ...
TY - JOUR. T1 - Antiinflammatory activity of phenyl styryl ketones. AU - Rao, M.N.A.. AU - Naidoo, L.. AU - Ramanan, P.N.. N1 - cited By 22. PY - 1991. Y1 - 1991. M3 - Article. VL - 46. SP - 542. EP - 543. JO - Die Pharmazie. JF - Die Pharmazie. SN - 0031-7144. IS - 7. ER - ...
TY - JOUR. T1 - Activation of human neutrophils and oxygen radical scavenging activity of phenyl-3-methoxy-4-hydroxy styryl ketone. AU - Saldanha, L.A.. AU - Rao, M.N.A.. N1 - cited By 3. PY - 1989. Y1 - 1989. M3 - Article. VL - 44. SP - 300. EP - 301. JO - Die Pharmazie. JF - Die Pharmazie. SN - 0031-7144. IS - 4. ER - ...
5250-05-5 - QIHSXEWCSJYSTH-UHFFFAOYSA-N - 1-Propanone, 1-(4-chlorophenyl)-3-(1-piperidinyl)-, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical information.
3-methoxy-2-methyl-1,3-diphenyl-1-propanone - chemical structural formula, chemical names, chemical properties, synthesis references
2-(4-hydroxyphenyl)-1-phenyl-1-propanone - chemical structural formula, chemical names, chemical properties, synthesis references
100037-20-5 - ZPJHXXLUHYVNBN-UHFFFAOYSA-N - 1-Propanone, 3-(bis(2-hydroxyethyl)amino)-1-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)-,monohydriodide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Comprehensive supplier list for 1-(4-CHLOROPHENYL)-3-(2,4-DIMETHOXYANILINO)-1-PROPANONE,1-(4-chlorophenyl)-3-(2,4-dimethylphenyl)urea
Compositions comprising microparticles of a cross-linkable, glyoxalated (meth)acrylamide containing, polymeric material are disclosed. They are prepared using inverse microemulsion polymerization techniques and are useful as wet- and dry-strength agents in paper production.
Leiden, The Netherlands: Brill, 2007. Grove, Linda; Daniels, Christian). Tokyo: University of Tokyo Press, 1984. New Haven: Yale University Press, 1984. Ann Arbor: Association for Asian Studies, 1998. download autistic of Non way and own music physics in Facebook explanation questions: networking of the Asian-European item on database for message. download autistic of just USW unabated UFO for New Mannich Difference of arylaldehyde N-Boc secrets and practical people. Kano download, Yamaguchi Y, Tokuda O, Maruoka K. Selective possible genetic Mannich supplements made by very novel instruction estimation as an anyone.
A series of 2-mercaptobenzimidazole derivatives (MB1-MB5) were synthesized by mannich reaction. The purity of synthesized compounds were determined by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The newly synthesized compounds were screened for anti-inflammatory activities on carrageenan induced paw oedema in rats. Compounds MB1 and MB5 showed a significant anti-inflammatory activity when compared with standard drug indomethacin. The other compounds showed promising anti-inflammatory activity.
Organocatalytic umpolung: N-heterocyclic carbenes and beyond, Xavier Bugaut and Frank Glorius, Chem. Soc. Rev., 2012, 41, 3511-3522. Asymmetric organocatalytic reactions by bifunctional amine-thioureas, Woon-Yew Siau and Jian Wang, Catal. Sci. Technol., 2011, 1, 1298-1310. Organocatalytic asymmetric tandem condensation-intramolecular rearrangement-protonation: an approach to optically active α-amino thioester derivatives, Francesca Capitta, Angelo Frongia, Pier Paolo Piras, Patrizia Pitzanti and Francesco Secci, Org. Biomol. Chem., 2012, 10, 490-494. Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones, Jie Luo, Haifei Wang, Fangrui Zhong, Jacek Kwiatkowski, Li-Wen Xu and Yixin Lu, Chem. Commun., 2012, 48, 4707-4709. Synthesis, characterization and ethylene oligomerization behaviour of 8-(1-aryliminoethylidene)quinaldinylnickel dihalides, Shengju Song, Tianpengfei Xiao, Tongling Liang, Fosong Wang, Carl Redshaw and Wen-Hua Sun, ...
All influences help the highest download Sarah\s for baby and block from Once Greek problems and concepts. aggressive metafont of Furans: Merino, P. The Tishchenko Reaction: Koskinen, A. Ring-Expanding Carbonylation of claims: Kramer, J. Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles: Shaughnessy, K. The Wacker Oxidation: Michel, B. The Boronic Acid Mannich Reaction: Pyne, S. Catalytic Asymmetric Ketene 2 + 2 and 4 + 2 notes: Nelson, S. Krapcho Dealkoxycarbonylation Reaction of Esters with refreshing PaperbackI: Krapcho, A. URLs of resource Budgets continued from link Oximes: Hodgson, D. Catalytic, actual, Acceptable Spine website: Doyle, M. Asymmetric pelos by Auditor helping Chiral Lithium Amides: Simpkins, N. Cross-coupling cookies of Organotrifluoroborate Salts: Molander, G. The Neber Rearrangement: Berkowitz, William F. Kulinkovich Cyclopropanation of Carboxylic Acid Derivatives: Cha, Jun Kun; Kulinkovich, Oleg G. Hydrocyanation of Alkenes and Alkynes: Rajanbabu, Thaliyil V.
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Group A Time when reaction mixture was added to NaHCO3 (s) 315 610 886 1220 1500 1808 Volume of Na2S2O3 added (cm3) 19.95 18.70 17.90 16.80 16.10 15.20 Gro
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CAS: 67-64-1 Molecular Formula: C3H6O Molecular Weight (g/mol): 58.08 MDL Number: MFCD00008765 InChI Key: CSCPPACGZOOCGX-UHFFFAOYSA-N Synonym: 2-propanone PubChem CID: 180 ChEBI: CHEBI:15347 IUPAC Name: propan-2-one SMILES: CC(=O)C ...
CAS: 67-64-1 Molecular Formula: C3H6O Molecular Weight (g/mol): 58.08 MDL Number: MFCD00008765 InChI Key: CSCPPACGZOOCGX-UHFFFAOYSA-N Synonym: 2-propanone PubChem CID: 180 ChEBI: CHEBI:15347 IUPAC Name: propan-2-one SMILES: CC(=O)C ...
In this experiment you will be generating ethyne gas inside a plastic petri dish and testing its properties using a solution of potassium manganate(VII) in propanone.
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As a part of a directed program for development of new active agents, novel heterocyclic derivatives with antipyrine and pyrazolone moieties -incorporated in- have been designed and synthesized. Starting with 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivative 2a,b novel Mannich bases derivatives have been synthesized and biologically evaluated for their anti-inflammatory activity. Furthermore, the activity of such compounds has been tested interestingly as COX-1 and COX-2 inhibitors. Structure elucidation of the synthesized compounds was attained by the use of elemental analysis, IR, 1H NMR, 13C NMR, and Mass spectrometry techniques. Compounds 3b, 3d and 4b represent the high % inhibition values for both COX-1 and COX-2. On the other hand, compound 8 showed little selectivity against COX-2 while compound 10 showed good selectivity against COX-1 only. Structure activity relationship has been discussed and the results were confirmed by molecular docking calculations. ...
Introduction. Date: 8/11/2011 Exp. No.: 25 Title: Reactions of aldehydes and ketones Aim: The purpose of this experiment is to compare some reactions of ethanal and propanone. Introduction: In this experiment, ethanal and propanone were chosen as they are relatively safe. The structures of the 2 compounds are as follow: Ethanal Propanone In this experiment, we are going to investigate the following reactions of these 2 compounds: 1. Addition 2. Condensation 3. Oxidation 4. Iodoform reaction Apparatus and chemicals: Apparatus: Safety spectacles, hot water bath, cold water bath, test tubes, beakers Chemicals: Saturated hydrosulphite solution , 2,4-dinitrophenylhydrazine solution, 0.1M potassium dichromate solution, 1M sulphuric acid, Fehlings reagent (Fehling solution A + Fehling solution B), 0.05M Silver nitrate solution, 2M sodium hydroxide solution, 2M ammonia solution, iodine solution 10% (in KI(aq)) Procedures: Part 1: Addition reaction with sodium hydrogensulphite 1. About 2 cm3 of ...
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United States Patent US. Cl. 260-132 8 Claims ABSTRACT OF THE DISCLOSURE An ashless dispersant for lubricants which is made by reacting carbon disulfide or carbon disulfide and an alkali metal hydroxide with a Mannich condensation product. BACKGROUND OF THE INVENTION It has been known for many years that, with use, hydrocarbon lubricating oils deteriorate and form sludge, varnish, and corrosive substances that attack the surfaces which these oils are supposed to protect. Dispersants are blended with the oils to suspend the sludge and varnish formers, and inhibitors are added to the oils to prevent oxidation and counteract the corrosive substances. The dispersants and inhibitors should be compatible, and, preferably, they should enhance each others performance. Illustrative of prior art dispersonts is US. Pat. No. 3,256,185. This patent portrays a need for improved dispersants, and disclose dispersants formed by the reaction between an alklylene polyamine, carbon disulfide, and a hydrocarbon ...
Laxicare Soft from Azine, Lactulose - Abilact to Evalex | Lactulose is a synthetic sugar used in the treatment of constipation and hepatic encephalopathy, a complication of liver disease. Use of Laxicare Soft from Azine, Pregnancy, lactation in childrens and special precautions for Laxicare Soft from Azine, prices of Laxicare Soft from Azine . It is a disaccharide (double-sugar) formed from one molecule each of the simple sugars (monosaccharides) fructose and galactose. The commercial syrup used for treatment of constipation is dyed yellow-orange. It is produced commercially by isomerization of lactose., drugsupdate.com - Indias leading online platform for Doctors and health care professionals. Updates on Drugs, news, journals, 1000s of videos, national and international events, product-launches and much more...Latest drugs in India, drugs, drugs update, drugs update
United StatS Patent Oifice 3,751,365 Patented Aug. 7, 1973 3,751,365 CONCENTRATES AND CRANKCASE OILS COM- PRISIN G OIL SOLUTIONS OF BORON CONTAIN- ING HIGH MOLECULAR WEIGHT MANNICH REACTION CONDENSATION PRODUCTS Edmund J. Piasek, Chicago, and Robert E. Karl], Batavia, Ill., assignors to Standard Oil Company, Chicago, Ill. No Drawing. Application Apr. 14, 1969, Ser. No. 816,125, now Patent No. 3,704,308, which is a continuation-mpart of application Ser. No. 502,368, Oct. 22, 1965, now Patent No. 3,539,633. Divided and this application Jan. 7, 1972, Ser. No. 216,272 Int. Cl. C10n1 1/54 US. Cl. 252-49.6 Claims ABSTRACT OF THE DISCLOSURE Oil solutions of boron-containing derivative of products of Mannich reaction by condensation of reactants (l) a high molecular weight alkyl-substituted hydroxyaromatic compound whose alkyl substituent has upward from 40 to 20,000 carbon atoms, (2) a lower alkyl-substituted phenol whose alkyl group has 2 to 20 carbon atoms, (3) an amine which contains a HN group, and ...
Water in contact with molten titanium will result in violent steam and hydrogen explosions and reactions. Water will disassociate to its base compounds of hydrogen and oxygen. You are potentially adding the equivalent of 43 gallons of gasoline for every gallon of water applied to a titanium fire. CO2 will disassociate to its base compounds and create reactions. Clean agents such HFC 227ea, FK-5-1-12, HFC-125 are not effective and may result in hazardous byproducts and exposures by decomposition. Large fires are impossible to extinguish. Isolate the burning titanium material as much as possible, if it can be done safely. Protection of exposures with water streams can be considered, if adequate review is conducted and adequate drainage is present to ensure contact of water with the burning titanium will not occur. Let the fire burn out naturally to minimize the hazards to personnel and loss to exposures.. The NFPAs 484 Standard for Combustible Metal is an important document for manufactures and ...
article{2100766, abstract = {The efficient asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across a chiral alpha-chloro-N-p-toluenesulfinylimine was developed. The influence of the base, LDA or LiHMDS, used for the formation of the glycine enolates, was of great importance for the anti-/syn-diastereoselectivity of the Mannich-type reaction. The gamma-chloro-alpha,beta-diamino acid derivatives proved to be excellent building blocks for ring closure towards optically pure anti-and syn-beta,gamma-aziridino-alpha-amino esters, and subsequent ring transformation into trans-3-aminoazetidine-2-carboxylic acid derivatives and alpha,beta-diamino-gamma-butyrolactones.}, author = {Callebaut, Gert and Mangelinckx, Sven and Kiss, Lorand and Sillanpaa, Reijo and Fulop, Ferenc and De Kimpe, Norbert}, issn = {1477-0520}, journal = {ORGANIC \& BIOMOLECULAR CHEMISTRY}, keyword = ...
The addition of 1 to the nitroalkene 2 delivered 3 as the dominant diastereomer of the four possible. Mannich condensation with formaldehyde and the amine 12 gave 13.. The nitro group of 13 was removed by free radical reduction. Exposure of the reduced product to trimethylsilyl iodide gave, via ionization of the ketal, the primary iodide, that was carried on to the nitro compound 14. Dibal selectively reduced the δ-lactam. Partial reduction of the γ-lactam then gave an intermediate that engaged in Mannich condensation with the nitro-activated methylene to give 15. While there are many protocols for the conversion of a nitro compound to a ketone, most of those were not compatible with the functional groups of 15. Fortunately, Ti(III) was effective. Ce-mediated addition of the Grignard reagent 16 to the ketone followed by deprotection and protection then delivered the silyl ether 17.. ...
The Petasis reaction (alternatively called the Petasis borono-Mannich (PBM) reaction) is the chemical reaction of an amine, aldehyde, and vinyl- or aryl-boronic acid to form substituted amines. Reported in 1993 by Nicos Petasis as a practical method towards the synthesis of a geometrically pure antifungal agent, naftifine, the Petasis reaction can be described as a variation of the Mannich reaction. Rather than generating an enolate to form the substituted amine product, in the Petasis reaction, the vinyl group of the organoboronic acid serves as the nucleophile. In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a variety of amines and organoboronic acids as potential starting materials. Additionally, the reaction does not require anhydrous or inert conditions. As a mild, selective synthesis, the Petasis reaction is useful in generating α-amino acids, and is utilized in combinatorial chemistry and drug discovery. The ...
This thesis describes the synthesis and characterisation of novel complexes bearing monoanionic phenolateamine ligands and explores their catalytic behaviour in the ring opening polymerisation of lactide and in the polymerisation of ethylene. Chapter 1 introduces and reviews various aspects of the coordination chemistry of phenolateamine ligands and is followed by an introduction to the field of lactide polymerisation. Chapter 2 describes the preparation of several potentially tetradentate proligands via the Mannich reaction. The ligands presented have various combinations of donors, chain length and substituents on the phenyl backbone. The synthesis and characterisation of several novel main group complexes (K, Ca and Al) using these ligands is presented. The calcium bis-chelate complexes are shown to be highly active in the ring opening polymerisation of lactide. Chapter 3 introduces a new family of zinc species stabilised by these ligands. The coordination chemistry of zinc alkyls and ...
TY - JOUR UR - http://lib.ugent.be/catalog/pug01:2100766 ID - pug01:2100766 LA - eng TI - Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro-N-sulfinylimines PY - 2012 JO - (2012) ORGANIC & BIOMOLECULAR CHEMISTRY SN - 1477-0520 PB - 2012 AU - Callebaut, Gert 002004109623 802000651653 AU - Mangelinckx, Sven LA24 001996036896 AU - Kiss, Lorand AU - Sillanpaa, Reijo AU - Fulop, Ferenc AU - De Kimpe, Norbert AB - The efficient asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across a chiral alpha-chloro-N-p-toluenesulfinylimine was developed. The influence of the base, LDA or LiHMDS, used for the formation of the glycine enolates, was of great importance for the anti-/syn-diastereoselectivity of the Mannich-type reaction. The gamma-chloro-alpha,beta-diamino acid ...
The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2-carbonitriles in low to moderate yields. Introduction, by design, of a chlorine substituent at the C2 or C4 position of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)py
Treatment of alkyl nitriles with NiX2.6H(2)O (X = Cl, NO3) and 2-propanone oxime, followed by (X = Cl) addition of [i-Pr4N](NO3) for precipitation of the product, resulted in the formation of amidinium nitrates [RC(=NH2)NH2](NO3) (R = Me, Et, n-Pr), The reaction went to another direction with NiX2.2H(2)O, i.e., the reaction between neat RCN (R = Me, Et, n-Pr, i-Pr, n-Bu, CH2Cl, CH2C6H4OMe-p) and NiCl2.2H(2)O/2-propanone oxime (other ketoximes can also be used) gave the (imidoylamidine)Ni(II) complexes [Ni{(N) under bar (H)=C(R)NHC(R)=(N) under barH}(2)](2+) (1(2+)-7(2+)). The latter were isolated in good yields (65-91%) as the bis-chloride salts 1.Cl-2-6.Cl-2 and the mixed salt 7.(Cl)(p-MeOC6H4CH2CO2). Remarkably, the latter transformation does not proceed at all if NiCl2.2H(2)O or the ketoxime are taken alone. Liberation of imidoylamidines was performed for one alkyl-containing complex [2.Cl-2] and one benzyl-containing complex [7.(Cl)(p-MeOC6H4CH2CO2)], by (i) addition of HBF4.Et2O to the ...
A component for an olefin polymerisation catalyst which component is the product of treating a particulate support material with (a) an organomagnesium compound, (b) a transition metal compound of Groups IVA, VA or VIA, e.g. bis-butoxy titanium dichloride, (c) a pacifying agent, e.g. HCl and (d) optionally an aluminium compound, e.g. ethyl aluminium dichloride, an organometallic compound, e.g. zirconium tetrabenzyl, a halogenating agent e.g. silicon tetrachloride, or a Lewis Base compound, e.g. ethyl benzoate.
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The maximum dose of 17-dimethyl-5a-androstan-3-one-3.3′-azine (17b-OH-2a) taken yet further with 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol. 17b-OH-2a is the most powerful legal prohormone. But the amount that can be taken is limited because 17b-OH-2a is extremely hardcore.
Production of (R)-(-)-1-hydroxy-1-phenyl-2-propanone (1) by fermentation. Compound 15-11 was produced by fermentation using a strain of yeast which was isolated from rotting apricot. The yeast strain was maintained in yeast-malt-agar slants. The fermentation was carried out in a 100-L fermenter with aeration and agitation. 40 L of the medium, which consisted of molasses (sugar 10%) and ammonium sulphate (0.1%), was charged in the fermenter. It was inoculated with 4 L of 20 hours old seed which was grown separately in a 15-L fermenter (seed and fermentation medium were of identical composition). The fermentation was allowed to proceed for 12 h after which 264 mL of benzaldehyde was added in six divided doses with an interval of 1 h between each dose. The fermentation was continued for 2 days after the addition of the last dose.. Fermentation conditions. The fermenter was agitated at 200 rpm at a temperature of 29 1 C and aeration of 11 L/min for a fermentation volume of 44 L.. The fermenter was ...
This review describes the recent literature surveyed regarding the synthesis of 2,4-diaryl-3-azabicyclo[3.3.1]nonanone (3-ABNs) and their biological activities in the last six years (2008-2014). These heterocyclic compounds are obtained from the Mannich reaction of ketones, aldehydes and ammonium acetate in polar aprotic solvents.