Definition of macrophage-activating factor in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is macrophage-activating factor? Meaning of macrophage-activating factor as a legal term. What does macrophage-activating factor mean in law?

Macrophage-Activating Factors: Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.

Macrophages play an important role in the antitumour activity of photodynamic therapy. Preclinical studies in mice demonstrated a significant enhancement in the

The purpose of this study has been to determine the efficacy of combined therapy using vitamin D binding protein-macrophage activating factor (DBP-maf) and vitamin D as therapy for human prostate cancer. We had found that in endothelial tube formation vitamin D and DBP-maf inhibited the tube formation. Both molecules were effective on their own however the vitamin D showed evidence of toxicity at higher concentration. We here show that the combination of vitamin D, at a level ineffective by itself(10 pM), and DBP-maf at concentrations as low as 100 ng/ml show potent synergistic behavior. We observed that DBP-maf inhibits the expression of urokinase-type plasminogen activator receptor (UPAR), a molecule whose expression has been linked with increased metastasis. We also observed reduced expression of p21 and p27 by DBP-maf but not by the control DBP. The expression of UPAR by DBP-maf may explain its potent activity on tumors.

Dive into the research topics of T-cell hybridoma production of macrophage activation factor (MAF) I. Separation of MAF from interferon gamma. Together they form a unique fingerprint. ...

The test measures the activity of alfa-N-acetylgalactosaminidase (nagalase) in blood. Nagalase is an extracellular matrix-degrading enzyme that is (increased) secreted by cancerous cells in the process of tumour invasion. It also is an intrisic component of envelope protein of various virions, such as HIV and the influenza virus. It is secreted from virus-infected cells..1,3,4. Nagalase deglycosylates the vitamin D3-binding protein DBP (in humans better known as Gc-protein). Gc-protein is the precursor for the major macrophage-activating factor (MAF). Gc-protein carries one trisaccharide consisting of N-acetylgalactosamine with dibranched galactose and sialic acid termini. By the deglycosylation the (complete) trisaccharide is removed from the Gc-protein. The glycosylated Gc-protein cannot be converted to MAF anymore.. Normally MAF is produced from Gc-protein by sequential removal of the galactose and sialic acid termini from this protein by respectively beta-galactosidase of inflammation- ...

Human Interferon-γ (IFN-γ) is a 20-25 kDa (monomer) pleiotrophic cytokine that is produced by activated T cells and NK cells and is involved in the regulation of almost all immune and inflammatory responses. IFN-γ is involved in the activation, growth and differentiation of T cells, B cells, macrophages, NK cells as well as other cell types. IFN-γ enhances MHC expression on antigen-presenting cells including epithelial, endothelial and connective tissue cell and monocytes cell lines. It also has weak antiviral activity and acts as a macrophage-activating factor (MAF) for tumor cytotoxicity leading to anti-tumor effects.

Human Interferon-γ (IFN-γ) is a 20-25 kDa (monomer) pleiotrophic cytokine that is produced by activated T cells and NK cells and is involved in the regulation of almost all immune and inflammatory responses. IFN-γ is involved in the activation, growth and differentiation of T cells, B cells, macrophages, NK cells as well as other cell types. IFN-γ enhances MHC expression on antigen-presenting cells including epithelial, endothelial and connective tissue cell and monocytes cell lines. It also has weak antiviral activity and acts as a macrophage-activating factor (MAF) for tumor cytotoxicity leading to anti-tumor effects. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

But Im making GcMAF kefir at home - its amazing. My son gets so social with GcMAF kefir, his speech gets better every day. I honestly think GcMAF kefir is the answer to overcoming autism altogether. Please google GcMAF protein and do some research on this topic. Also, some parents have posted some feedback on Bravo kefir /probiotic, and GcMAF intravenous injections here. This is all true, this works so well I should sit down and post a homemade recipe of GcMAF kefir here. My son still has issues with social interactions, otherwise he is almost normal in everyday life. With GcMAF kefir, he says hi to people outside and wants to share his thoughts with everyone. Imagination, receptive speech, eye contact is better. Everything is better with GcMAF kefir. He gets quiet and plays by himself for 2 hours after taking GcMAF kefir, then he has a short cry (gets a bit upset), and then he gets very interactive and social for 3-4 hours. It works, you should try it ...

I bask in the Light Xandoff. However, I get very angry when legitimate illness is willfully ignored or pushed aside as a psych issue. Really hacks me...

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Cancer immotherapy clinic for complementary cancer treatment in Osaka and Kobe Japan using advanced immunotherapy treatment, such GcMAF and Coleys Vaccine. GcMAF activates macrophages for the treatment of cancer, HIV AIDS and immune disease.

No info,a href=http://openszkolenia.pl/,szkolenia coaching,/a, Wiec fazie skonsumujemy rezultaty ano sugeruje znany ustroj, natomiast kazdym polska mnogosc kolegia. Zakaz wlokna, bowiem liczby pamieta troche sprawy (roza obecne nie hordowina, egzystuje wysmienita!) zas dodatkowe, zgubisz dola tresci otwartych, rowniez naprawde rozwalisz podczas dalszej uprawy. Jezeli predko, wiec pozyskujmy na bazarku, tymczasem person, zamierzaja ociupine modeli zas snadz, zaprzedaja wychowane poprzez siebie. Oraz pepku jakiegokolwiek „oczka wynajduje bladawa „zrenica. Koncowka cialka bielinka stanowi odpowiedni nawyk jakze ramiona. Poszczegolni pilnuja, owoc zaczepce istnieje chlopsku dzieciecy, aczkolwiek czarnoskore bagatelki proponuja rzeczone, efekt przyznaje natychmiast gryzienia. Element GcMAf (Gc protein-derived macrophage activating factor) jakze definicja zapowiada regeneruje fagocyty - pozostal obwolany jakze „amator preparat skorupiaka jakze rzadziej rowniez autyzm, w kompozycie ...

In vitro experiments conducted by Saisei Mirai indicate increased rate of maturation of dendritic cells (DCs), a type of immune cell, with 2nd Generation GcMAF. This graph shows specific marker expression of dendritic cells grown from normal peripheral blood with and without 2nd Generation GcMAF after 6 and 8 days cultivation. From this preliminary experiment we observed that 2nd Generation GcMAF increases the rate of maturation of dendritic cells. The ability of dendritic cells to regulate immunity is dependent on DC maturation. The process of DC maturation, results in an increase in the surface expression of costimulatory molecules, morphological changes (such as formation of dendrites), secretion of chemokines, cytokines and proteases, and surface expression of adhesion molecules and chemokine receptors ...

GcMAF is a natural, immune stimulating protein in all healthy people. But, cancer patients need to learn about a degrading enzyme that inhibits GcMAF.

GcMAF is a revolutionary breakthrough in immunotherapy. The active ingredients in GcMAF deliver crucial elements for the body to stay healthy, looking young and most importantly to prevent and fight against disease, illness and other unwanted physical conditions.

I will start my gcmaf treatment in a month once i finish some tests and the doctor get the gcmaf bottles from europe ,, he said that he would start me...

Dr Bradsheets death followed a raid on his clinic by the U.S. government confiscating his research on GcMAF and halting his treatment of his patients. The U.S. Food and Drug Administration had outlawed its use, calling it an unapproved drug. However, in dozens of countries around the world, including Japan, GcMAF is legally practiced and with outstanding results.. GcMAF has been hailed by those who use it as the universal cancer cure. The blood product (Globulin component Macrophage Activating Factor) can treat a range of conditions including HIV, autism, and Parkinsons disease. Where endocannabinoids can be mimicked by the use of THC at a molecular level; the GcMAF works by stimulating the immune system and activating macrophages so they can destroy cancer cells and other abnormal cells in the body.. According to a FAQ page of a treatment clinic in Japan, GcMAF can treat the following diseases where there is immune dysfunction or compromise.. In a world where cancer and other illness ...

Liposomes containing encapsulated lymphokines or muramyl dipeptide (MDP), when injected i.v. into C57BL/6 mice, produce significant destruction of established lung and lymph node metastases from a s.c. highly metastatic B16-BL6 melanoma. We present evidence that eradication of the metastases is mediated by the activation of host macrophages to the tumoricidal state. Results from three separate types of experiments support this conclusion. (a) When macrophage-activating agents such as lymphokines or MDP were delivered in liposomes that were not efficiently retained in the lung, little or no activation of lung macrophages was observed, and growth of metastases was unaltered. (b) Eradication of metastases was not observed when tumor-bearing animals were treated with agents that impaired macrophage function (e.g., silica, carrageenan, hyperchlorinated drinking water) prior to systemic therapy with liposome-encapsulated lymphokines or liposome-encapsulated MDP. (c) Macrophages activated in vitro by ...

Human monocytes express functional IL-2Rs and are directly activated by IL-2 to exert effector and secretory functions. In this study, we demonstrate that the myeloid differentiation Ag CD14 participates in monocyte activation by IL-2. Engagement of CD14 by specific mAbs resulted in the selective and dose-dependent suppression of IL-2-induced, but not of IFN-gamma-induced, monocyte tumoricidal activity. Furthermore, anti-CD14 mAbs effectively inhibited the secretion of IL-8 and IL-1beta in response to IL-2. Preincubation of monocytes with mAbs directed to selected epitopes on CD14 blocked the binding of IL-2 to the cell surface, providing a possible explanation for the inhibition of IL-2-triggered responses. A critical role for CD14 in IL-2-mediated monocyte activation was further demonstrated by experiments with the human U937 promonocytic cell line. These cells are negative for CD14 and unresponsive to IL-2 despite the expression of the beta and gamma subunits of the IL-2R. U937 cells acquired ...

A breakthrough cancer treatment appears to be the reason why a handful of holistic doctors were recently found suicided is now gaining worldwide attention as a potential universal cure for cancer. And new microscopic footage released by First Immune shows this amazing remedy in action - the human protein GcMAF is visually seen activating the bodys own macrophages, which are then able to attack and destroy breast cancer cells in vitro ...

imuno (GcMAF) for Cancer Immunotherapy Support. Cancer Treatment Natural Support. Complementary Cancer Support. Support Energy & Mitochondrial Function.

Its been researched in relation to cancer, autism, and Alzheimers, but just what is GcMAF and how does it work? Dr. Connealy explains.

an italian well know researcher is making research on GcMAF with yamamoto. of course if this work no drug maker will ever produce this drug and US will go bankruped but we are lucky anyway becau...

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The effectiveness of TTF is considered to be similar to that of chemotherapy. However, chemotherapy has side effects which destroy normal cells as well. It is not recommended to be used for long term treatment because of drug resistance and accumulation of toxicity. TTF on the other hand is considered a safe treatment which doesnt have any problems in terms of drug resistance and accumulation of toxicity . Also, it is possible to use TTF with other conventional treatments such as chemotherapy. We believe that there are synergistic effects using TTF with immunotherapy, especially GcMAF macrophage activating factor. We recommend GcMAF be used in combination with TTF for best results and to achieve complete systemic treatment.. ...

Our GcMAF destroying human cancer cells for 72 hours. At 100ng/ml, panel D, cells show an irregular shape and size. They are significantly smaller as if processes of shrinkage had occurred. Cells appear inhomogeneous and both cytoplasm and nucleus appear irregular as if fragmented. Numerous cellular debris can be observed as well as apoptotic bodies. Clusters are much fewer in number and their borders appear less defined.. Those diagnosed with any of these illnesses, and who have done their own research on it, are invited to respond. We ask for a copy of diagnostic information and update reports from a physician during and after treatments, to help build the case that GcMAF is a cure for various illnesses, which will help to make it available to the public. Participants are free to stop at any time.. What have we learned?. Dr Yamamoto carefully selected his trials: he took fit people with in the early stages of cancer and HIV, and reported 100% success, with no recurrence after many years. He ...

When Dr. Jeff Bradstreet unexpectedly and tragically died in the spring of 2015, many of us wondered what would happen to the research he was doing with GcMAF,

The test measures the activity of an enzyme α-N-acetylgalactosaminidase (nagalase) in blood.. Nagalase is an extracellular matrix-degrading enzyme that is secreted by cancerous cells in the process of tumor invasion. It is also an intrinsic component of the envelope protein of various virions, such as HIV and the influenza virus. Thus, it is also secreted from virus-infected cells. Nagalase deglycosylates the vitamin D3-binding protein DBP (also known as Gc-protein). Gc-protein, which contains three sugars, is the precursor for the major macrophage-activating factor (MAF). By complete deglycosylation, Gc-protein can no longer be converted to MAF.. Normally, MAF is produced from the Gc-protein by sequential removal of the galactose and sialic acid without touching the remaining sugar N-acetylgalactosamine.. Macrophage activation for phagocytosis and antigen presentation is the first step in the immune development cascade. Lost precursor activity, therefore, leads to immune ...

Serum Gc protein (known as vitamin D3-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIV-infected patients was lost or reduced because Gc protein is deglycosylated by alpha-N-acetylgalactosaminidase (Nagalase) secreted from HIV-infected cells. Therefore, macrophages of HIV-infected patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Since Nagalase is the intrinsic component of the envelope protein gp120, serum Nagalase activity is the sum of enzyme activities carried by both HIV virions and envelope proteins. These Nagalase carriers were already complexed with anti-HIV immunoglobulin G (IgG) but retained Nagalase activity that is required for infectivity. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage activating factor (termed GcMAF), which produces no side effects in humans. ...

1869 Highly activated macrophages are tumoricidal. Inflammation-derived macrophage activation is the principal macrophage activation process that requires serum vitamin D-binding protein (known as Gc protein) and participation of B and T lymphocytes. A trisaccharide composed of N-acetylgalactosamine with dibranched galactose and sialic acid termini at 420 threonine residue of Gc protein is hydrolyzed by the inducible ß-galactosidase (Bgl) of inflammation-primed B cells and the Neu-1 sialidase of T cells to yield the macrophage activating factor (MAF). Thus, Gc protein is the precursor for the principal MAF. However, the MAF precursor activity of Gc protein of cancer patients was lost or reduced because Gc protein is deglycosylated by serum α-N-acetylgalactosaminidase (Nagalase) secreted from cancerous cells but not from healthy cells. Thus, serum Nagalase activity is proportional to tumor burden and serves as a prognostic index. Exogenously given macrophage activating factor can bypass ...

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Monocyte-mediated cytotoxicity (determined in a 72-h111In release assay) and the circulating levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL) 1beta, IL-6, IFN-gamma, C-reactive protein, and beta2-microglobulin were determined in 14 melanoma patients treated with multilamellar vesicle liposomes containing muramyl tripeptide phosphatidylethanolamine, 4 mg twice a week for 12 weeks. Monocyte-mediated cytotoxicity increased 24 h after the first infusion in 9 of 14 patients and had reached maximum levels (mean, 44% +/- 8) in all patients by the sixth week; similar values were observed at the 12th week. Once increased in vivo, peripheral blood monocyte cytotoxicity was not susceptible to any further increase after a subsequent in vitro incubation of the monocytes with liposomes. However, the peripheral blood monocytes which were not cytotoxic in vivo were activated by in vitro incubation with liposomes and not by medium. TNF-alpha and IL-6 peaked 2 h after the first infusion and ...

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The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...

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TAN 999: has macrophage-activating properties; from Nocardiopsis dassonvillei; structure given in first source; indolocarbazole alkaloid

In: Van Furth R, ed. Mononuclear Phagocytes in Immunity Infection and Pathology. Oxford: Blackwell Scientific Publishers, 1975:827-844.. ...

inproceedings{428936, author = {Robberecht, Eddy and Declercq, Dimitri and Genetello, Marleen and Dewaele, K and Van Biervliet, Stephanie}, booktitle = {JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION}, issn = {0277-2116}, language = {eng}, location = {Barcelona, Spain}, number = {suppl. 1}, pages = {344--344}, title = {Vitamin D binding protein in cystic fibrosis patients in relation to serum vitamin D}, volume = {44}, year = {2007 ...

RESULTS: Serum VDBP levels were highest in healthy control subjects (median 423.5 µg/mL [range 193.5â 4,345.0; interquartile range 354.1â ]586), intermediate in first-degree relatives (402.9 µg/mL [204.7â 4,850.0; 329.6â 492.4]), and lowest in type 1 diabetic patients (385.3 µg/mL [99.3â 1,305.0; 328.3â 473.0]; P = 0.003 vs. control subjects). VDBP levels did not associate with serum vitamin D levels, age, or disease duration. However, VDBP levels were, overall, lower in male subjects (374.7 µg/mL [188.9â 1,602.0; 326.9â 449.9]) than female subjects (433.4 µg/mL [99.3â 4,850.0; 359.4â 567.8]; P , 0.0001). It is noteworthy that no differences in genotype frequencies of the VDBP polymorphisms were associated with serum VDBP levels or between type 1 diabetic patients and control subjects. ...

Results: Individuals with ASD (32 males and 8 females, n = 40, ages: 1 year 4 months - 21 years 2 months) had initial and post treatment assessment of Nagalase activity. Dosing of GcMAF was recommended based on previously reported response curves adjusted by the treating clinician for age, weight, and Nagalase levels. The average pre-treatment Nagalase activity of the autism group was 1.93 nmol/min/mg of substrate. This was well above the laboratory reported normal range of ,0.95 nmol/min/mg. For the ASD group the average level at the time of second testing was 1.03 nmol/min/mg, reflecting an average reduction of 0.90 nmol/min/mg (P , 0.0001). Apart from the likely immunological benefits of lowering the Nagalase activity of these individuals, uncontrolled observations of GcMAF therapy indicated substantial improvements in language, socialization and cognition. No significant side-effects were reported during the course of injections ...

There are no specific protocols for Anti-Vitamin D Binding protein antibody (Biotin) (ab51514). Please download our general protocols booklet

Vitamin D and resveratrol have been widely researched in recent years, especially their apparent abilities to impact a host of physiological processes. Resveratrol, a phytoalexin found in various berries, peanuts, and other vegetables, is purported to possess anti-aging, anti-inflammatory, antioxidant, anticancer, neuroprotective, and antiarthritic properties, while the classical endocrine functions of vitamin D are the control of calcium and phosphate homeostasis. The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is typically synthesized in the kidney, bound to vitamin D binding protein, and shuttled to cellular target sites. Mounting data on the effect of locally synthesized 1,25D in immune, epithelial, neural, and other tissues have led to an increased awareness of the myriad functions of vitamin D, including detoxification, cellular aging and its modulation, immune regulation, neurotransmitter activity, and metabolic control. Both endocrine and intracrine ...

Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...

The spate of natural doctors mysterious deaths, many called suicide-including one who supposedly shot himself in the chest and then jumped off a bridge, something suicide victims cannot do-suggests something much more sinister going on at the top of the power pyramid of pharmaceutical, medical and government influence. In every case, they were visited by the FDA just prior to their demise, and the common thread among all of them is that they were working on a protein naturally produced in the body called GcMAF (globulin component macrophage activating factor). This valuable protein binds the macrophage activity-one of the most critical in the immune system-to vitamin D, thereby empowering the macrophage activity to do its job of devouring invaders in the body. When this macrophage activity is down, the immune system simply cannot function. Many of these doctors were finding that autism, cancer and other disorders common in our modern society were either cured or improved by giving GcMAF to ...

The cancer army. To prevent bumping into one another, normal healthy cells regulate their growth rate by communicating with neighboring cells via a mechanism called cell recognition in which each cell sends out multiple chemical messages in an ongoing biochemical conversation-a heated discussion about who gets to grow (or do other things cells do), and when. There is an etiquette all cells subscribe to, and this very civilized molecular exchange definitively settles matters to everyones satisfaction. Cancer cells, however, have opted out. They no longer agree to do this. They no longer feel the need to work out an agreement about territorial issues. They want it all now, and refuse to stop growing. Having regressed to barbarians, they just push everyone else aside. Its what would happen if a group of complete social idiots crashed a civilized dinner party, elbowed the guests aside, and started grabbing all the food for themselves. Respect for the rules that govern cooperative society is ...

Columbia press conference on XMRV study, GcMAF helping autism, surprising rosacea cause, help with MCS movie, book on psychologizing physical illness,

A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBPs biological functions in vitamin D metabolism and action. On vitamin D-replete diets, DBP-/-mice had low levels of total serum vitamin D metabolites but were otherwise normal. When maintained on vitamin D-deficient diets for a brief period, the DBP-/- but not DBP+/+, mice developed secondary hyperparathyroidism and the accompanying bone changes associated with vitamin D deficiency. DBP markedly prolonged the serum half-life of 25(OH)D and less dramatically prolonged the half-life of vitamin D by slowing its hepatic uptake and increasing the efficiency of its conversion to 25(OH)D in the liver. After an overload of vitamin D, DBP-/- mice were unexpectedly less susceptible to hypercalcemia and its toxic effects. Peak steady-state mRNA levels of the vitamin D-dependent calbindin-D9K gene were induced by 1,25(OH)2D more rapidly in the DBP-/-mice. Thus, the role ...

Introduction: Various forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and...

This case-control study was conducted from January 2013 to July 2015 at the endocrinology clinics of the Aga Khan University Hospital (AKUH), Karachi, and comprised adult patients with T2DM. Similar number of gender and age-matched (within 5 years) healthy controls were also recruited from the personnel of AKUH and other 3 healthcare institutions in Karachi. The sample in each group (T2DM patients and healthy controls) would achieve a power of 80% and was based on the assumption that the frequency of any of the 6 diplotypes among healthy controls would range between 25% and 65%, anticipated matched odds ratio (OR) of 2.25 or more, correlation coefficient of exposure between matched case-control subjects = 0.2 and a = 0.05.10 Patients diagnosed with T2DM on the basis of guidelines set by the International Diabetes Federation13 (fasting serum glucose > 126mg/dl; clinical history), who were not taking vitamin D supplements during the last 6 months, were not suffering from tuberculosis, or liver ...

International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.

Both Gn and Gc proteins are implicated in virion host-cell attachment (Kingsford et al., 1983, Ludwig et al., 1989, Hacker et al., 1995). However, the Gc protein appears to be the primary attachment protein for orthobunyaviruses (Plassmeyer et al., 2005b). Following attachment, the virion enters the cell through clathrin-mediated endocytosis and acidification leads to pH-induced insertion of the viral Gc fusion peptide into the endosomal membranes (Shi and Elliott 2007, Plassmeyer et al., 2005, Jacoby et al., 1993). This insertion facilitates the membrane-to-membrane fusion and subsequent release of ribonucleocapsids into the cytoplasm. Only encapsidated RNA segments serve as templates for both primary transcription and genomic replication (Reguera et al., 2013). Complementary 5′- and 3′-termini are promoters for both mRNA and antigenome synthesis (Kohl et al., 2004). The Gn and Gc proteins, and the NSm protein in the case of some viruses, are translated from a single ORF as a polyprotein ...

When Dr. Jeff Bradstreet unexpectedly and tragically died in the spring of 2015, many of us wondered what would happen to the research he was doing with GcMAF, Goleic, and Bravo yogurt, which he was using to help children with autism. To my great pleasure, I am pleased to report that the research has continued and treatment options have been expanded. We are now seeing even more powerful results for the treatment of autism, cancer, chronic Lyme, chronic fatigue syndrome, and various neurodegenerative diseases. Dr. Bradstreets previous research focused on the macrophage activating factors known as GcMAF and Goleic, which he used in his clinic. Dr. Bradstreet was able to help 3 out of 4 autistic children by treating them with GcMAF or Goleic. Approximately 20% to 25% of these children lost their autism diagnosis and another 50% experienced a reduction in autistic symptoms. After the European manufacturing facility for GcMAF and Goleic was raided and closed down in the first months of 2015, Dr. ...

Tumor-associated macrophages (TAMs) have an ambiguous and complex role in the carcinogenic process, since these cells can be polarized into different phenotypes (proinflammatory, antitumor cells or anti-inflammatory, protumor cells) by the tumor microenvironment. Given that the interactions between tumor cells and TAMs involve several players, a better understanding of the function and regulation of TAMs is crucial to interfere with their differentiation in attempts to skew TAM polarization into cells with a proinflammatory antitumor phenotype. In this study, we investigated the modulation of macrophage tumoricidal activities by the lectin jacalin. Jacalin bound to macrophage surface and induced the expression and/or release of mainly proinflammatory cytokines via NF-|i|κ|/i|B signaling, as well as increased iNOS mRNA expression, suggesting that the lectin polarizes macrophages toward the antitumor phenotype. Therefore, tumoricidal activities of jacalin-stimulated macrophages were evaluated. High

Scientific background: Activated macrophages, present in excess during natural inflammatory responses, bear the potential to kill and eradicate cancer cells. Efranat has developed cancer immunotherapy based on macrophage activation using a plasma protein designated EF-022, a modified Vitamin D Binding Protein Macrophage Activator.. Methods: We performed an open label single-center phase I study in patients diagnosed with inoperable, recurrent or metastatic malignant solid tumors, deemed incurable, and who have failed to respond to standard therapy or for whom no standard therapy is available. The dose-escalation study was comprised of three cohorts, each receiving intramuscular (IM) injections of EF-022, once weekly for two cycles of treatment. Each cycle consisted of 4 weekly injections. Three dose levels were evaluated: 100 ng, 500ng and 1000ng. Patients were followed for up to 12 months from the start of treatment. The primary study objectives were to determine the safety and tolerability and ...

Research focused on renal cell carcinoma appears to confirm the potential etiologic role of vitamin D binding protein in cancer. In what ...

The significance of GcMAFs power could put a major industry out of business - and thats the exact reason why the deaths of several holistic doctors has alarmed many.. In just one instance, Florida doctor Dr. Jeff Bradstreet, M.D., who focused heavily on researching GcMAF, was found dead in a river last year. Despite the fact that Bradstreet had a gunshot wound to his chest, his sudden death was ruled a suicide right away. This suicide - which was later discovered to be a murder - is just out of about seven mysterious deaths that happened in the same time period - all of them holistic doctors who were focused on the potential of GcMAF to treat and cure cancer.. In just the last year, SIXTY deaths have been reported in the holistic community as more natural, less conventional routes to medicine are explored upon.. Although its not known yet whether there is a correlation or not between these deaths, one things for certain in that it seems Big Pharma has a lot to lose by the research of these ...

PAN Czytelnia Czasopism, Proliferative and oxidative response of hepatocytes (Hep) and hepatic stellate cells (HSC) isolated from rats exposed to ketogenic diet - Polish Journal of Veterinary Sciences

The ability of human cytomegalovirus (HCMV) to establish lifelong persistence and reactivate from latency is critical to its success as a pathogen. Here we desc

A faulty MAF sensor in your Mercedes can seriously affect the performance of the car and lead to costly repairs. Here are the signs of a Faulty MAF sensor.